TPRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.17588645
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.17588645
3positive regulation of antigen processing and presentation (GO:0002579)4.78082394
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66753278
5response to peptidoglycan (GO:0032494)4.64705536
6negative regulation of interleukin-12 production (GO:0032695)4.49374533
7regulation of vitamin D biosynthetic process (GO:0060556)4.45344545
8antigen processing and presentation of endogenous antigen (GO:0019883)4.34975543
9glycosphingolipid catabolic process (GO:0046479)4.26913148
10adhesion of symbiont to host (GO:0044406)4.24093896
11regulation of mononuclear cell migration (GO:0071675)4.20287693
12positive regulation of gamma-delta T cell activation (GO:0046645)4.18999332
13regulation of dendritic cell antigen processing and presentation (GO:0002604)4.18914074
14signal peptide processing (GO:0006465)4.13680469
15regulation of antigen processing and presentation (GO:0002577)4.11522844
16positive regulation of chemokine biosynthetic process (GO:0045080)4.07018775
17regulation of cellular extravasation (GO:0002691)4.04815597
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.03554284
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.01175122
20positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.92672806
21regulation of chemokine biosynthetic process (GO:0045073)3.83732263
22glycolipid catabolic process (GO:0019377)3.83139291
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74871738
24regulation of podosome assembly (GO:0071801)3.73575414
25oligosaccharide catabolic process (GO:0009313)3.69910851
26regulation of cytokine secretion involved in immune response (GO:0002739)3.68238158
27cellular response to thyroid hormone stimulus (GO:0097067)3.67833154
28amino sugar catabolic process (GO:0046348)3.64835049
29detection of bacterium (GO:0016045)3.63070255
30negative regulation of nitric oxide biosynthetic process (GO:0045019)3.61556092
31regulation of vitamin metabolic process (GO:0030656)3.59983938
32protein localization to endosome (GO:0036010)3.56766032
33angiogenesis involved in wound healing (GO:0060055)3.51318990
34cellular response to zinc ion (GO:0071294)3.49636568
35regulation of B cell receptor signaling pathway (GO:0050855)3.49250675
36cellular response to arsenic-containing substance (GO:0071243)3.44015602
37myeloid dendritic cell differentiation (GO:0043011)3.43084425
38detection of other organism (GO:0098543)3.42598107
39regulation of interferon-beta biosynthetic process (GO:0045357)3.42019839
40regulation of membrane protein ectodomain proteolysis (GO:0051043)3.41948037
41neutrophil activation involved in immune response (GO:0002283)3.37327988
42heme biosynthetic process (GO:0006783)3.35530965
43macrophage activation involved in immune response (GO:0002281)3.30809655
44T-helper 1 type immune response (GO:0042088)3.27102161
45negative regulation of myeloid cell apoptotic process (GO:0033033)3.26356280
46ceramide catabolic process (GO:0046514)3.25689758
47regulation of cholesterol storage (GO:0010885)3.25504322
48membrane lipid catabolic process (GO:0046466)3.23926885
49antigen processing and presentation via MHC class Ib (GO:0002475)3.19265590
50low-density lipoprotein particle clearance (GO:0034383)3.18931461
51response to thyroid hormone (GO:0097066)3.14506155
52phospholipid scrambling (GO:0017121)3.11758496
53definitive hemopoiesis (GO:0060216)3.10586149
54sphingolipid catabolic process (GO:0030149)3.10380559
55activation of MAPKKK activity (GO:0000185)3.07306755
56regulation of gamma-delta T cell differentiation (GO:0045586)3.05438888
57negative regulation of cytokine production involved in immune response (GO:0002719)3.05230685
58N-acetylneuraminate metabolic process (GO:0006054)3.04864850
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04470680
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.04433978
61positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02138536
62monocyte chemotaxis (GO:0002548)2.98421999
63virion attachment to host cell (GO:0019062)2.96247167
64adhesion of symbiont to host cell (GO:0044650)2.96247167
65negative regulation of erythrocyte differentiation (GO:0045647)2.95525469
66positive regulation of B cell differentiation (GO:0045579)2.94718491
67regulation of female gonad development (GO:2000194)2.91237163
68response to interferon-beta (GO:0035456)2.91191206
69Golgi transport vesicle coating (GO:0048200)2.85582820
70COPI coating of Golgi vesicle (GO:0048205)2.85582820
71protoporphyrinogen IX biosynthetic process (GO:0006782)2.85493988
72glycoside metabolic process (GO:0016137)2.84771123
73protoporphyrinogen IX metabolic process (GO:0046501)2.84690481
74regulation of gamma-delta T cell activation (GO:0046643)2.84291254
75detection of external biotic stimulus (GO:0098581)2.83128455
76branching involved in labyrinthine layer morphogenesis (GO:0060670)2.82815179
77heme metabolic process (GO:0042168)2.82366575
78negative regulation of phagocytosis (GO:0050765)2.82244486
79decidualization (GO:0046697)2.81831252
80positive regulation by symbiont of host defense response (GO:0052509)2.81543479
81modulation by symbiont of host defense response (GO:0052031)2.81543479
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81543479
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81543479
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.81543479
85modulation by symbiont of host immune response (GO:0052553)2.81543479
86regulation of T-helper 1 cell differentiation (GO:0045625)2.81007294
87immunoglobulin mediated immune response (GO:0016064)2.80758701
88pyrimidine-containing compound salvage (GO:0008655)2.80665163
89pyrimidine nucleoside salvage (GO:0043097)2.80665163
90endothelium development (GO:0003158)2.80261340
91porphyrin-containing compound biosynthetic process (GO:0006779)2.77098451
92mitochondrial calcium ion transport (GO:0006851)2.76872065
93cellular response to lipopolysaccharide (GO:0071222)2.76593138
94amyloid precursor protein catabolic process (GO:0042987)2.75923349
95germinal center formation (GO:0002467)2.75738397
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75597416
97response to protozoan (GO:0001562)2.74391718
98positive regulation of heat generation (GO:0031652)2.74115065
99pinocytosis (GO:0006907)2.73287399
100modulation by symbiont of host cellular process (GO:0044068)2.69145863
101mature B cell differentiation involved in immune response (GO:0002313)2.66650894
102regulation of monocyte chemotaxis (GO:0090025)2.65647240
103mannose metabolic process (GO:0006013)2.65478070
104positive regulation of NF-kappaB import into nucleus (GO:0042346)2.65259224
105response to type I interferon (GO:0034340)2.63375580
106regulation of interferon-alpha production (GO:0032647)2.63297732
107cellular response to molecule of bacterial origin (GO:0071219)2.63235231
108valine metabolic process (GO:0006573)2.63173016
109regulation of macrophage chemotaxis (GO:0010758)2.62467973
110regulation of nitric oxide biosynthetic process (GO:0045428)2.62358375
111vascular endothelial growth factor signaling pathway (GO:0038084)2.61563042
112NIK/NF-kappaB signaling (GO:0038061)2.60507789
113regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59729288
114negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57958103
115glial cell migration (GO:0008347)2.57666802
116barbed-end actin filament capping (GO:0051016)2.57288736
117positive regulation of lymphocyte apoptotic process (GO:0070230)2.57272870
118nucleotide salvage (GO:0043173)2.56705143
119cyclooxygenase pathway (GO:0019371)2.56666998
120type I interferon signaling pathway (GO:0060337)2.56626932
121cellular response to type I interferon (GO:0071357)2.56626932
122myeloid dendritic cell activation (GO:0001773)2.55828174
123regulation of fever generation (GO:0031620)2.55522531
124positive regulation of cholesterol efflux (GO:0010875)2.55073514
125erythrocyte development (GO:0048821)2.53359163
126response to progesterone (GO:0032570)2.52829317
127negative regulation of lipid storage (GO:0010888)2.52296707
128progesterone metabolic process (GO:0042448)2.52243988
129response to interferon-alpha (GO:0035455)2.52117966
130positive regulation of granulocyte differentiation (GO:0030854)2.51918025
131negative regulation of tumor necrosis factor production (GO:0032720)2.51846338
132regulation of mast cell degranulation (GO:0043304)2.51292845
133granulocyte activation (GO:0036230)2.50959713
134Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50336892
135regulation of hypersensitivity (GO:0002883)2.50032802
136negative regulation of stress fiber assembly (GO:0051497)2.47565952
137regulation of chronic inflammatory response (GO:0002676)2.47088827
138regulation of superoxide anion generation (GO:0032928)2.46835105
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.46775886
140sphingosine metabolic process (GO:0006670)2.46580126
141regulation of T-helper 2 cell differentiation (GO:0045628)2.45600275
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.45472234
143epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45466289
144defense response to protozoan (GO:0042832)2.45403523
145interferon-gamma-mediated signaling pathway (GO:0060333)2.45382408
146membrane protein intracellular domain proteolysis (GO:0031293)2.45305766
147regulation of early endosome to late endosome transport (GO:2000641)2.45024799
148detection of biotic stimulus (GO:0009595)2.44696382
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42440097
150dendritic cell differentiation (GO:0097028)2.42157705
151negative regulation of mast cell activation (GO:0033004)2.41782145
152positive regulation of respiratory burst (GO:0060267)2.41570001
153regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.39421511
154tetrapyrrole biosynthetic process (GO:0033014)2.38153509
155positive regulation of cellular amide metabolic process (GO:0034250)2.37940849
156regulation of interleukin-12 biosynthetic process (GO:0045075)2.37907021
157phagocytosis, recognition (GO:0006910)2.36456242
158respiratory burst (GO:0045730)2.36446477
159GDP-mannose metabolic process (GO:0019673)2.36203468
160ribosomal small subunit assembly (GO:0000028)2.35733480
161toxin transport (GO:1901998)2.35675626
162regulation of B cell differentiation (GO:0045577)2.34238531
163response to muramyl dipeptide (GO:0032495)2.32088399
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.30591315
165myeloid cell activation involved in immune response (GO:0002275)2.29592835
166positive regulation of triglyceride biosynthetic process (GO:0010867)2.29116039
167porphyrin-containing compound metabolic process (GO:0006778)2.28569899
168positive regulation of interferon-alpha production (GO:0032727)2.28066600
169regulation of necrotic cell death (GO:0010939)2.28032327
170negative regulation of glycoprotein biosynthetic process (GO:0010561)2.27895588
171positive regulation of macrophage differentiation (GO:0045651)2.26379048
172oxaloacetate metabolic process (GO:0006107)2.25970547
173positive regulation of natural killer cell differentiation (GO:0032825)2.24712112
174granulocyte differentiation (GO:0030851)2.23838793
175neutrophil mediated immunity (GO:0002446)2.23126010
176Notch receptor processing (GO:0007220)2.22925100
177viral protein processing (GO:0019082)2.22689464
178positive regulation of monocyte chemotaxis (GO:0090026)2.20844724
179erythrocyte maturation (GO:0043249)2.20212768
180positive regulation of humoral immune response (GO:0002922)2.19596619
181regulation of T cell receptor signaling pathway (GO:0050856)2.19499014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.33662008
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.13956693
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01222022
4SCL_19346495_ChIP-Seq_HPC-7_Human2.84575959
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81090866
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.76283182
7GATA1_22025678_ChIP-Seq_K562_Human2.73521491
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51902980
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47763451
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42089009
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38409230
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34127776
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29149124
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28118270
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26795298
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26195014
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22770754
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18212706
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16735732
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14185660
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12413478
22* VDR_21846776_ChIP-Seq_THP-1_Human2.10537350
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.08816125
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05339959
25* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01218182
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01147686
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.96943673
28ZNF263_19887448_ChIP-Seq_K562_Human1.89622103
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84721559
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83453656
31SPI1_23547873_ChIP-Seq_NB4_Human1.81811215
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.81011924
33MYC_22102868_ChIP-Seq_BL_Human1.80774178
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80767242
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.79366732
36VDR_24763502_ChIP-Seq_THP-1_Human1.74116894
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70770650
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69790564
39MAF_26560356_Chip-Seq_TH1_Human1.67653906
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67359936
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64371327
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.63066523
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60928647
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60343855
45GATA1_19941826_ChIP-Seq_K562_Human1.60126419
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58796265
47RUNX_20019798_ChIP-Seq_JUKART_Human1.57508481
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55779612
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55549898
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.54979684
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52724686
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52420184
53KDM2B_26808549_Chip-Seq_DND41_Human1.52114727
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.50896646
55SPI1_23127762_ChIP-Seq_K562_Human1.50045186
56UTX_26944678_Chip-Seq_JUKART_Human1.49547079
57* LXR_22292898_ChIP-Seq_THP-1_Human1.49289023
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.47289383
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47025862
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42675662
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41336865
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.39835828
63MYB_26560356_Chip-Seq_TH2_Human1.39542867
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37931551
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35742581
66* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35666771
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34154826
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33790116
69* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33109184
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.30072325
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.29504147
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29405086
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29350162
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29344942
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28797521
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27608588
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27003510
78MYB_26560356_Chip-Seq_TH1_Human1.25896075
79* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25407413
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24855837
81BCOR_27268052_Chip-Seq_Bcells_Human1.24848533
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22580468
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22110314
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21838683
85P68_20966046_ChIP-Seq_HELA_Human1.21785998
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21569831
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21062617
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20205631
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.19840819
90GATA2_19941826_ChIP-Seq_K562_Human1.19453052
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.16823103
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16027017
93KDM2B_26808549_Chip-Seq_K562_Human1.15809902
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15027802
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14573221
96MAF_26560356_Chip-Seq_TH2_Human1.13906061
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13776273
98BCL6_27268052_Chip-Seq_Bcells_Human1.13675176
99ATF3_27146783_Chip-Seq_COLON_Human1.13383159
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12459683
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12227382
102NCOR1_26117541_ChIP-Seq_K562_Human1.11378746
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09987205
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09351860
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09199938
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09120409
107GATA3_27048872_Chip-Seq_THYMUS_Human1.08758861
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08006807
109GATA3_26560356_Chip-Seq_TH2_Human1.07005995
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07002784
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.06574146
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05973220
113TP53_22127205_ChIP-Seq_IMR90_Human1.05700282
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05145410
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04108357
116CLOCK_20551151_ChIP-Seq_293T_Human1.03970649
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03613948
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01647236
119RACK7_27058665_Chip-Seq_MCF-7_Human1.00585868
120* TFEB_21752829_ChIP-Seq_HELA_Human1.00385093
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.00020029
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99633876
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99586154
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98864895
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98847859
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98473182
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96892908
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96817255
129PU_27001747_Chip-Seq_BMDM_Mouse0.96390503
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95811202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.36483370
2MP0004147_increased_porphyrin_level3.35876095
3MP0003191_abnormal_cellular_cholesterol3.02346158
4MP0001835_abnormal_antigen_presentation2.76687035
5MP0006054_spinal_hemorrhage2.69327783
6MP0005451_abnormal_body_composition2.67184467
7MP0005058_abnormal_lysosome_morphology2.66444736
8MP0003656_abnormal_erythrocyte_physiolo2.64391329
9MP0002139_abnormal_hepatobiliary_system2.56650163
10MP0005671_abnormal_response_to2.34908168
11MP0003724_increased_susceptibility_to2.29450694
12MP0001873_stomach_inflammation2.22656984
13MP0005397_hematopoietic_system_phenotyp2.21816670
14MP0001545_abnormal_hematopoietic_system2.21816670
15MP0009785_altered_susceptibility_to2.20391465
16MP0003436_decreased_susceptibility_to2.17292989
17MP0010368_abnormal_lymphatic_system2.13893087
18MP0003806_abnormal_nucleotide_metabolis2.13615473
19MP0000685_abnormal_immune_system2.10792772
20MP0003453_abnormal_keratinocyte_physiol2.07621362
21MP0003172_abnormal_lysosome_physiology2.04896505
22MP0009278_abnormal_bone_marrow2.02363875
23MP0002148_abnormal_hypersensitivity_rea2.00547415
24MP0002419_abnormal_innate_immunity1.97579427
25MP0003300_gastrointestinal_ulcer1.93015791
26MP0009840_abnormal_foam_cell1.88809660
27MP0005387_immune_system_phenotype1.87918306
28MP0001790_abnormal_immune_system1.87918306
29MP0003705_abnormal_hypodermis_morpholog1.84496878
30MP0005025_abnormal_response_to1.83595999
31MP0005000_abnormal_immune_tolerance1.83289610
32MP0002396_abnormal_hematopoietic_system1.82870928
33MP0002254_reproductive_system_inflammat1.82102628
34MP0008260_abnormal_autophagy1.81270508
35MP0004510_myositis1.80886563
36MP0002452_abnormal_antigen_presenting1.76376921
37MP0005464_abnormal_platelet_physiology1.75102149
38MP0004947_skin_inflammation1.67397191
39MP0002723_abnormal_immune_serum1.66290718
40MP0002166_altered_tumor_susceptibility1.65852228
41MP0001800_abnormal_humoral_immune1.64129978
42MP0005167_abnormal_blood-brain_barrier1.61174414
43MP0002420_abnormal_adaptive_immunity1.60571636
44MP0001819_abnormal_immune_cell1.60405484
45MP0003448_altered_tumor_morphology1.54055426
46MP0009333_abnormal_splenocyte_physiolog1.53776799
47MP0002405_respiratory_system_inflammati1.53365320
48MP0001853_heart_inflammation1.50507948
49MP0000372_irregular_coat_pigmentation1.47466776
50MP0005075_abnormal_melanosome_morpholog1.47056786
51MP0004808_abnormal_hematopoietic_stem1.43378537
52MP0000689_abnormal_spleen_morphology1.39980782
53MP0001879_abnormal_lymphatic_vessel1.38586685
54MP0003866_abnormal_defecation1.37761043
55MP0002398_abnormal_bone_marrow1.36602896
56MP0010155_abnormal_intestine_physiology1.36265512
57MP0001845_abnormal_inflammatory_respons1.36080499
58MP0001849_ear_inflammation1.34304501
59MP0009764_decreased_sensitivity_to1.33321898
60MP0008469_abnormal_protein_level1.31339124
61MP0008438_abnormal_cutaneous_collagen1.29932479
62MP0003183_abnormal_peptide_metabolism1.29400953
63MP0002877_abnormal_melanocyte_morpholog1.29054666
64MP0003329_amyloid_beta_deposits1.27590036
65MP0000465_gastrointestinal_hemorrhage1.26223591
66MP0002722_abnormal_immune_system1.26185410
67MP0009379_abnormal_foot_pigmentation1.25605942
68MP0003763_abnormal_thymus_physiology1.24944632
69MP0000716_abnormal_immune_system1.24641423
70MP0005174_abnormal_tail_pigmentation1.23798528
71MP0005408_hypopigmentation1.22634348
72MP0003943_abnormal_hepatobiliary_system1.22255738
73MP0002429_abnormal_blood_cell1.21641519
74MP0000490_abnormal_crypts_of1.19515415
75MP0001542_abnormal_bone_strength1.18075002
76MP0005166_decreased_susceptibility_to1.17991220
77MP0000013_abnormal_adipose_tissue1.15586658
78MP0003279_aneurysm1.14442857
79MP0005310_abnormal_salivary_gland1.13223110
80MP0003950_abnormal_plasma_membrane1.12980601
81MP0001533_abnormal_skeleton_physiology1.12078255
82MP0000343_altered_response_to1.11728978
83MP0002006_tumorigenesis1.11553985
84MP0001756_abnormal_urination1.10594839
85MP0009643_abnormal_urine_homeostasis1.09282307
86MP0004858_abnormal_nervous_system1.08140801
87MP0005257_abnormal_intraocular_pressure1.07807685
88MP0003091_abnormal_cell_migration1.06445869
89MP0003566_abnormal_cell_adhesion1.05912731
90MP0000249_abnormal_blood_vessel1.04608595
91MP0005076_abnormal_cell_differentiation1.03884640
92MP0002332_abnormal_exercise_endurance1.03570007
93MP0000604_amyloidosis1.03549449
94MP0005083_abnormal_biliary_tract1.03528923
95MP0008004_abnormal_stomach_pH1.01560442
96MP0002909_abnormal_adrenal_gland1.01100445
97MP0000015_abnormal_ear_pigmentation0.99627756
98MP0006036_abnormal_mitochondrial_physio0.98666075
99MP0000858_altered_metastatic_potential0.95241440
100MP0005164_abnormal_response_to0.94074963
101MP0003690_abnormal_glial_cell0.93567409
102MP0002138_abnormal_hepatobiliary_system0.93419327
103MP0006082_CNS_inflammation0.92923585
104MP0005390_skeleton_phenotype0.92658119
105MP0005636_abnormal_mineral_homeostasis0.90267039
106MP0009763_increased_sensitivity_to0.88880757
107MP0001851_eye_inflammation0.88482800
108MP0000749_muscle_degeneration0.86107564
109MP0010386_abnormal_urinary_bladder0.85436098
110MP0000609_abnormal_liver_physiology0.84407901
111MP0002136_abnormal_kidney_physiology0.83048593
112MP0005165_increased_susceptibility_to0.82655467
113MP0010307_abnormal_tumor_latency0.81616646
114MP0003795_abnormal_bone_structure0.81008082
115MP0005365_abnormal_bile_salt0.80821913
116MP0005023_abnormal_wound_healing0.80379321
117MP0010329_abnormal_lipoprotein_level0.79692590
118MP0003075_altered_response_to0.79562077
119MP0002090_abnormal_vision0.79308806
120MP0008007_abnormal_cellular_replicative0.78699333
121MP0003828_pulmonary_edema0.76896900
122MP0000920_abnormal_myelination0.76127321
123MP0000750_abnormal_muscle_regeneration0.76056526
124MP0002095_abnormal_skin_pigmentation0.75411718
125MP0005319_abnormal_enzyme/_coenzyme0.74873211
126MP0003186_abnormal_redox_activity0.74514556
127MP0002998_abnormal_bone_remodeling0.74488184
128MP0001663_abnormal_digestive_system0.72536933
129MP0001243_abnormal_dermal_layer0.72225196
130MP0003634_abnormal_glial_cell0.72001010
131MP0008874_decreased_physiological_sensi0.70347113
132MP0001216_abnormal_epidermal_layer0.69778294
133MP0004233_abnormal_muscle_weight0.68826473
134MP0000747_muscle_weakness0.65240389
135MP0000681_abnormal_thyroid_gland0.65017878
136MP0002933_joint_inflammation0.61737313
137MP0005595_abnormal_vascular_smooth0.60062999

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.42511654
2Recurrent abscess formation (HP:0002722)4.33943409
3Vacuolated lymphocytes (HP:0001922)4.29327942
4Increased cerebral lipofuscin (HP:0011813)4.14992638
5Nuclear cataract (HP:0100018)4.05796592
6Petechiae (HP:0000967)3.87125883
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.85088221
8Disinhibition (HP:0000734)3.77489522
9Dysostosis multiplex (HP:0000943)3.49855490
10Neurofibrillary tangles (HP:0002185)3.30217582
11Recurrent bacterial skin infections (HP:0005406)3.29977008
12Elevated erythrocyte sedimentation rate (HP:0003565)3.25090891
13Axonal loss (HP:0003447)3.22816480
14Mutism (HP:0002300)3.18178873
15Thrombocytosis (HP:0001894)3.17608787
16Abnormality of liposaccharide metabolism (HP:0010968)3.16921566
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.16921566
18Abnormality of glycolipid metabolism (HP:0010969)3.16921566
19Nonimmune hydrops fetalis (HP:0001790)3.09969140
20Myositis (HP:0100614)3.07509965
21Urinary glycosaminoglycan excretion (HP:0003541)2.82520519
22Mucopolysacchariduria (HP:0008155)2.82520519
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81761113
24Abnormality of the nasal mucosa (HP:0000433)2.81368013
25Loss of speech (HP:0002371)2.76163560
26Prolonged neonatal jaundice (HP:0006579)2.73538921
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72067031
28Abnormality of polysaccharide metabolism (HP:0011012)2.72067031
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72067031
30Eczematoid dermatitis (HP:0000976)2.71754062
31Upper motor neuron abnormality (HP:0002127)2.71302276
32Hand muscle atrophy (HP:0009130)2.68839151
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.68489512
34Progressive neurologic deterioration (HP:0002344)2.68303168
35Glomerulonephritis (HP:0000099)2.66406362
36Myocardial infarction (HP:0001658)2.66260617
37Interstitial pulmonary disease (HP:0006530)2.65495714
38Cerebral inclusion bodies (HP:0100314)2.60097233
39Neuronal loss in central nervous system (HP:0002529)2.59452973
40Pustule (HP:0200039)2.59012500
41Asymmetric septal hypertrophy (HP:0001670)2.57412409
42Abnormal platelet function (HP:0011869)2.55379284
43Impaired platelet aggregation (HP:0003540)2.55379284
44Increased IgE level (HP:0003212)2.55095996
45Colitis (HP:0002583)2.50976956
46Hepatosplenomegaly (HP:0001433)2.47000059
47Epistaxis (HP:0000421)2.46398238
48Prolonged bleeding time (HP:0003010)2.46345257
49IgM deficiency (HP:0002850)2.41383711
50Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41183528
51Nasal polyposis (HP:0100582)2.38993718
52Autoimmune thrombocytopenia (HP:0001973)2.36908673
53Spontaneous hematomas (HP:0007420)2.34328508
54Abnormality of macrophages (HP:0004311)2.28056125
55Distal upper limb amyotrophy (HP:0007149)2.26808058
56Upper limb amyotrophy (HP:0009129)2.26808058
57Chronic otitis media (HP:0000389)2.25778534
58Microretrognathia (HP:0000308)2.25116456
59Complement deficiency (HP:0004431)2.24749590
60Abnormal number of erythroid precursors (HP:0012131)2.24347728
61Obstructive lung disease (HP:0006536)2.23196157
62Chronic obstructive pulmonary disease (HP:0006510)2.23196157
63Inflammation of the large intestine (HP:0002037)2.20490188
64Recurrent skin infections (HP:0001581)2.20483757
65Orchitis (HP:0100796)2.18741113
66Gastrointestinal inflammation (HP:0004386)2.18596763
67Polycythemia (HP:0001901)2.17287148
68Abnormality of complement system (HP:0005339)2.16716851
69Thoracic kyphosis (HP:0002942)2.16307128
70Recurrent viral infections (HP:0004429)2.15831630
71Retrobulbar optic neuritis (HP:0100654)2.13833419
72Optic neuritis (HP:0100653)2.13833419
73Mediastinal lymphadenopathy (HP:0100721)2.13656359
74Abnormality of fatty-acid metabolism (HP:0004359)2.13635921
75Muscle stiffness (HP:0003552)2.13375370
76Personality changes (HP:0000751)2.13327930
77Gastrointestinal stroma tumor (HP:0100723)2.12899610
78Achilles tendon contracture (HP:0001771)2.12712561
79Ileus (HP:0002595)2.12699580
80Vertebral compression fractures (HP:0002953)2.11031124
81Malnutrition (HP:0004395)2.08883212
82Abnormality of cells of the erythroid lineage (HP:0012130)2.08460114
83Dementia (HP:0000726)2.08070486
84Bone pain (HP:0002653)2.06080797
85Hypertensive crisis (HP:0100735)2.05169226
86Reduced antithrombin III activity (HP:0001976)2.04847276
87Generalized aminoaciduria (HP:0002909)2.03810135
88Sensorimotor neuropathy (HP:0007141)2.03563949
89Recurrent fungal infections (HP:0002841)2.02210652
90Hepatic necrosis (HP:0002605)2.01315951
91Stomatitis (HP:0010280)2.01256378
92Cardiomegaly (HP:0001640)1.96901101
93Amyloidosis (HP:0011034)1.96731679
94Metaphyseal irregularity (HP:0003025)1.96074713
95Cervical subluxation (HP:0003308)1.94775031
96Joint stiffness (HP:0001387)1.93887854
97Premature rupture of membranes (HP:0001788)1.93524834
98Increased serum ferritin (HP:0003281)1.92971206
99Supranuclear gaze palsy (HP:0000605)1.92925994
100Thin bony cortex (HP:0002753)1.92162085
101Esophageal neoplasm (HP:0100751)1.91862330
102Neoplasm of head and neck (HP:0012288)1.91862330
103Recurrent gram-negative bacterial infections (HP:0005420)1.89470848
104Cholecystitis (HP:0001082)1.89011937
105Abnormal gallbladder physiology (HP:0012438)1.89011937
106Hypoglycemic coma (HP:0001325)1.88865891
107Purpura (HP:0000979)1.87882444
108Hepatocellular necrosis (HP:0001404)1.87742177
109Abnormality of the intrinsic pathway (HP:0010989)1.87007114
110Ragged-red muscle fibers (HP:0003200)1.86757405
111Pulmonary infiltrates (HP:0002113)1.85270917
112Abnormality of the Achilles tendon (HP:0005109)1.84118027
113Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83324164
114Diminished motivation (HP:0000745)1.82963058
115Hyperbilirubinemia (HP:0002904)1.81707663
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80882880
117Abnormal protein N-linked glycosylation (HP:0012347)1.80882880
118Abnormal protein glycosylation (HP:0012346)1.80882880
119Abnormal glycosylation (HP:0012345)1.80882880
120Hematochezia (HP:0002573)1.80605809
121Mesangial abnormality (HP:0001966)1.80568888
122Cholelithiasis (HP:0001081)1.80504540
123Urticaria (HP:0001025)1.78655231
124Abnormality of iron homeostasis (HP:0011031)1.78591118
125Pathologic fracture (HP:0002756)1.78404612
126Ketoacidosis (HP:0001993)1.76026307
127Agnosia (HP:0010524)1.75954403
128J-shaped sella turcica (HP:0002680)1.74634859
129Abnormality of transition element cation homeostasis (HP:0011030)1.74591978
130Type I transferrin isoform profile (HP:0003642)1.74575022
131Vasculitis (HP:0002633)1.74527738
132Emphysema (HP:0002097)1.72511301
133Spondylolisthesis (HP:0003302)1.72461843
134Abnormality of the thoracic spine (HP:0100711)1.72185684
135Elevated alkaline phosphatase (HP:0003155)1.71984509
136Recurrent bronchitis (HP:0002837)1.71975746
137Growth hormone excess (HP:0000845)1.71866844
138Abnormal gallbladder morphology (HP:0012437)1.71077175
139Gingivitis (HP:0000230)1.70416584
140Inappropriate behavior (HP:0000719)1.70374424
141Distal lower limb muscle weakness (HP:0009053)1.70231953
142Fatigue (HP:0012378)1.69411256
143Peripheral demyelination (HP:0011096)1.68055560
144Broad face (HP:0000283)1.66565394
145Apathy (HP:0000741)1.65963211
146Retinal atrophy (HP:0001105)1.64032867
147Basal ganglia calcification (HP:0002135)1.63457450
148Cellulitis (HP:0100658)1.62024857
149Multiple enchondromatosis (HP:0005701)1.60573331
150Abnormality of lateral ventricle (HP:0030047)1.60274538
151Tetraparesis (HP:0002273)1.60255447
152Nausea (HP:0002018)1.59936030
153Short nail (HP:0001799)1.59655097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.87630813
2ERN13.44185258
3TAOK23.33268193
4MAP3K132.76309875
5KDR2.76012432
6PRPF4B2.62826268
7TBK12.59000000
8TYK22.56875535
9DDR22.49776331
10PIM22.49679333
11KIT2.41792352
12TAOK32.24325630
13GRK72.11630908
14SMG12.10762074
15TAOK12.10055296
16MOS2.04452198
17NME22.00806547
18JAK31.97504463
19TGFBR21.97211477
20MAP4K11.96856317
21ARAF1.95912665
22MYLK1.93812504
23BCKDK1.90326161
24TESK11.86372688
25MAPKAPK31.86157350
26MAP3K121.80330893
27MAP3K141.67208434
28EEF2K1.62100468
29TESK21.58029819
30NLK1.56430923
31MAP2K31.53710159
32IKBKE1.53203081
33TGFBR11.51853554
34LRRK21.50374606
35TEC1.48931454
36ZAP701.45259042
37INSRR1.45088493
38FLT31.41941990
39GRK11.41708236
40IRAK31.36766904
41BMPR21.36452039
42EPHA31.35076721
43PAK41.33964549
44CAMKK21.30455005
45FGR1.29926060
46IRAK41.29729543
47CDC42BPA1.27378552
48ICK1.18907525
49STK101.16975342
50JAK11.13420344
51TTN1.10075903
52CSK1.09852745
53TRPM71.08773991
54IKBKB1.07575902
55BTK1.06227488
56ITK1.03573792
57RIPK41.03109843
58IRAK21.01655426
59SYK1.00528127
60PDGFRA0.98124334
61MAPK120.94205877
62TRIB30.87802879
63PTK60.84755951
64EPHB20.80145489
65MAP2K20.80119949
66PRKD20.79774303
67ACVR1B0.78874306
68SIK30.76387852
69GRK60.75503812
70PKN20.75347928
71SCYL20.74791055
72MAPKAPK50.74685508
73JAK20.74188059
74MAP3K50.73965645
75EPHA20.72361451
76MAPK150.70505954
77LIMK10.70306525
78MAP3K110.68496774
79NEK90.67897927
80MATK0.66527405
81RPS6KA20.65144319
82CSF1R0.65044868
83RPS6KB20.64163540
84MAPK110.63020576
85LCK0.61185082
86PRKCH0.60265090
87PRKG20.59915246
88BRAF0.59418349
89LYN0.59262417
90MAP3K80.58951638
91CHUK0.57897459
92CDK80.57850173
93KSR20.57377561
94HIPK20.57373951
95MUSK0.57339190
96SIK10.56502823
97PIM10.56024297
98BMX0.55830686
99RPS6KA60.55756980
100LATS20.52432067
101PTK2B0.52185501
102EPHB10.52156035
103MST1R0.51582783
104DAPK30.50274426
105MARK20.49306873
106DAPK10.49111449
107PDK20.48988573
108FES0.48810502
109BMPR1B0.48723317
110RPS6KC10.48435691
111RPS6KL10.48435691
112MAP2K60.47928618
113MAPKAPK20.47692340
114MAP3K10.46384561
115CDK60.46176371
116MAPK40.44999661
117FGFR40.44791733
118PBK0.44312996
119MAP3K30.41476151
120MAP2K10.40637377
121RIPK10.40550311
122PDPK10.40227077
123VRK10.40070233
124MAP3K60.38982583
125DYRK1B0.37866729
126TXK0.36063912
127MARK30.35020366
128PRKCD0.34791246
129IRAK10.34690953
130BLK0.33948144
131AURKA0.33570199
132CLK10.33212292
133RPS6KA40.32760424
134ABL20.32717616
135MAPK30.32370062
136CDK40.30879099
137TYRO30.29280445
138PAK10.28929846
139CAMK2G0.27012709
140PAK20.26860086
141PKN10.26244168
142SIK20.25753105
143ADRBK20.25576189
144GSK3A0.25243556
145HCK0.25203646

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.72761793
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.48239574
3Lysosome_Homo sapiens_hsa041423.09834866
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.29284818
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18605912
6Protein export_Homo sapiens_hsa030602.15782379
7Collecting duct acid secretion_Homo sapiens_hsa049661.88580595
8Malaria_Homo sapiens_hsa051441.82953501
9Rheumatoid arthritis_Homo sapiens_hsa053231.80901762
10Leishmaniasis_Homo sapiens_hsa051401.74299662
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.73847388
12Prion diseases_Homo sapiens_hsa050201.66525350
13Allograft rejection_Homo sapiens_hsa053301.65292157
14Bladder cancer_Homo sapiens_hsa052191.64859728
15Staphylococcus aureus infection_Homo sapiens_hsa051501.59432014
16Pertussis_Homo sapiens_hsa051331.58925361
17Phagosome_Homo sapiens_hsa041451.56671807
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.55825264
19Hematopoietic cell lineage_Homo sapiens_hsa046401.52801151
20Asthma_Homo sapiens_hsa053101.50674521
21Sulfur relay system_Homo sapiens_hsa041221.50467483
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48925752
23Primary immunodeficiency_Homo sapiens_hsa053401.46244609
24Osteoclast differentiation_Homo sapiens_hsa043801.45090641
25Galactose metabolism_Homo sapiens_hsa000521.40704998
26Graft-versus-host disease_Homo sapiens_hsa053321.38632192
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38451606
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.32998076
29Apoptosis_Homo sapiens_hsa042101.32227946
30Ovarian steroidogenesis_Homo sapiens_hsa049131.31813100
31Folate biosynthesis_Homo sapiens_hsa007901.29510011
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26213419
33Sulfur metabolism_Homo sapiens_hsa009201.25429824
34Shigellosis_Homo sapiens_hsa051311.24904758
35B cell receptor signaling pathway_Homo sapiens_hsa046621.24609835
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23511424
37Autoimmune thyroid disease_Homo sapiens_hsa053201.20607747
38Legionellosis_Homo sapiens_hsa051341.18540339
39Sphingolipid metabolism_Homo sapiens_hsa006001.18154261
40Tuberculosis_Homo sapiens_hsa051521.16327342
41N-Glycan biosynthesis_Homo sapiens_hsa005101.15352212
42Toxoplasmosis_Homo sapiens_hsa051451.14785197
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12421764
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12324543
45Vibrio cholerae infection_Homo sapiens_hsa051101.11748067
46Measles_Homo sapiens_hsa051621.10515243
47Oxidative phosphorylation_Homo sapiens_hsa001901.10050674
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.08558747
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.08478124
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07170962
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03368670
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02985979
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00639921
54Fructose and mannose metabolism_Homo sapiens_hsa000510.99872729
55Amoebiasis_Homo sapiens_hsa051460.98155344
56Parkinsons disease_Homo sapiens_hsa050120.97965197
57ABC transporters_Homo sapiens_hsa020100.97097636
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96126569
59Viral myocarditis_Homo sapiens_hsa054160.94090852
60Antigen processing and presentation_Homo sapiens_hsa046120.92900990
61Type I diabetes mellitus_Homo sapiens_hsa049400.88241444
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87668674
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86365980
64Influenza A_Homo sapiens_hsa051640.86150553
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86097690
66Hepatitis C_Homo sapiens_hsa051600.85683554
67Platelet activation_Homo sapiens_hsa046110.84620619
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84076366
69Caffeine metabolism_Homo sapiens_hsa002320.83207911
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82735121
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80369678
72Vitamin digestion and absorption_Homo sapiens_hsa049770.76095498
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75108875
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74539763
75Peroxisome_Homo sapiens_hsa041460.72796562
76HIF-1 signaling pathway_Homo sapiens_hsa040660.71545176
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70942999
78VEGF signaling pathway_Homo sapiens_hsa043700.70371144
79Alzheimers disease_Homo sapiens_hsa050100.70199726
80Epstein-Barr virus infection_Homo sapiens_hsa051690.68724250
81Acute myeloid leukemia_Homo sapiens_hsa052210.66961874
82Base excision repair_Homo sapiens_hsa034100.64966916
83Pancreatic cancer_Homo sapiens_hsa052120.63211378
84Bile secretion_Homo sapiens_hsa049760.63161911
85Ribosome_Homo sapiens_hsa030100.62565963
86TNF signaling pathway_Homo sapiens_hsa046680.62204819
87Glutathione metabolism_Homo sapiens_hsa004800.62044599
88Notch signaling pathway_Homo sapiens_hsa043300.61050953
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60830143
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59790820
91Hepatitis B_Homo sapiens_hsa051610.58712656
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57881379
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.57182962
94Chronic myeloid leukemia_Homo sapiens_hsa052200.55870387
95HTLV-I infection_Homo sapiens_hsa051660.55602958
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54959098
97Endocytosis_Homo sapiens_hsa041440.52877753
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52392488
99DNA replication_Homo sapiens_hsa030300.52320258
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50889225
101Salmonella infection_Homo sapiens_hsa051320.50529887
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.50367301
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50140726
104Herpes simplex infection_Homo sapiens_hsa051680.48728692
105Fatty acid degradation_Homo sapiens_hsa000710.48707526
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48287073
107Viral carcinogenesis_Homo sapiens_hsa052030.47812007
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47788313
109Complement and coagulation cascades_Homo sapiens_hsa046100.47771819
110Histidine metabolism_Homo sapiens_hsa003400.46795025
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46527704
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46444684
113Pentose phosphate pathway_Homo sapiens_hsa000300.46095269
114Chemokine signaling pathway_Homo sapiens_hsa040620.44573503
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.44413067
116PPAR signaling pathway_Homo sapiens_hsa033200.43970573
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.43902735
118Insulin resistance_Homo sapiens_hsa049310.41833219
119Mineral absorption_Homo sapiens_hsa049780.40076801
120Carbon metabolism_Homo sapiens_hsa012000.39816827
121Prolactin signaling pathway_Homo sapiens_hsa049170.39584405
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.38989736
123Systemic lupus erythematosus_Homo sapiens_hsa053220.38634691
124African trypanosomiasis_Homo sapiens_hsa051430.35814269
125Tyrosine metabolism_Homo sapiens_hsa003500.35219775
126Renin-angiotensin system_Homo sapiens_hsa046140.34388670
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.33348583
128Small cell lung cancer_Homo sapiens_hsa052220.33115795
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.32395849
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32370183
131Proteoglycans in cancer_Homo sapiens_hsa052050.30923514
132Biosynthesis of amino acids_Homo sapiens_hsa012300.27430548
133T cell receptor signaling pathway_Homo sapiens_hsa046600.23585090
134Synaptic vesicle cycle_Homo sapiens_hsa047210.23098574

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