ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.62503964
2	glutamate secretion (GO:0014047)	4.01544570
3	synaptic vesicle maturation (GO:0016188)	3.88423986
4	sodium ion export (GO:0071436)	3.64870306
5	cellular potassium ion homeostasis (GO:0030007)	3.50018776
6	regulation of synaptic vesicle exocytosis (GO:2000300)	3.49489145
7	regulation of ARF protein signal transduction (GO:0032012)	3.44091146
8	synaptic vesicle exocytosis (GO:0016079)	3.21525225
9	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.17767209
10	regulation of early endosome to late endosome transport (GO:2000641)	3.06761950
11	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.05694636
12	regulation of synaptic vesicle transport (GO:1902803)	3.01903368
13	protein localization to endosome (GO:0036010)	2.99305596
14	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.90333208
15	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.77606761
16	positive regulation of Rap GTPase activity (GO:0032854)	2.70535912
17	cerebellar granule cell differentiation (GO:0021707)	2.67989932
18	locomotory exploration behavior (GO:0035641)	2.64494901
19	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.62193381
20	barbed-end actin filament capping (GO:0051016)	2.53523817
21	positive regulation of protein dephosphorylation (GO:0035307)	2.49859860
22	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.49083318
23	signal complex assembly (GO:0007172)	2.48282246
24	L-amino acid import (GO:0043092)	2.47536849
25	positive regulation of receptor recycling (GO:0001921)	2.46937471
26	regulation of neuronal synaptic plasticity (GO:0048168)	2.46439729
27	stress fiber assembly (GO:0043149)	2.43338121
28	positive regulation of fibroblast migration (GO:0010763)	2.40468351
29	neurotransmitter secretion (GO:0007269)	2.38509328
30	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.38103754
31	NADH metabolic process (GO:0006734)	2.33865777
32	amino acid import (GO:0043090)	2.31664840
33	regulation of extracellular matrix disassembly (GO:0010715)	2.31652994
34	negative regulation of erythrocyte differentiation (GO:0045647)	2.31259930
35	mannose metabolic process (GO:0006013)	2.28962973
36	receptor recycling (GO:0001881)	2.28762722
37	potassium ion homeostasis (GO:0055075)	2.28582862
38	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.27968557
39	negative regulation of cell killing (GO:0031342)	2.27968557
40	regulation of Rap GTPase activity (GO:0032317)	2.24094163
41	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.23953646
42	ethanol oxidation (GO:0006069)	2.20622927
43	positive regulation of synapse maturation (GO:0090129)	2.20542040
44	regulation of protein dephosphorylation (GO:0035304)	2.19484371
45	negative regulation of dendrite morphogenesis (GO:0050774)	2.18298590
46	regulation of synaptic plasticity (GO:0048167)	2.16069439
47	regulation of cholesterol homeostasis (GO:2000188)	2.15620901
48	positive regulation of extracellular matrix organization (GO:1903055)	2.15518160
49	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.14444021
50	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.14186391
51	cell communication by electrical coupling (GO:0010644)	2.11324588
52	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.10280288
53	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.08402241
54	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.06321351
55	actin filament capping (GO:0051693)	2.05635210
56	actin filament depolymerization (GO:0030042)	2.05391677
57	regulation of regulated secretory pathway (GO:1903305)	2.03176171
58	cellular sodium ion homeostasis (GO:0006883)	2.03003926
59	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.02923359
60	negative regulation of protein localization to plasma membrane (GO:1903077)	2.01218560
61	positive regulation of neurotransmitter secretion (GO:0001956)	2.00843324
62	exploration behavior (GO:0035640)	2.00397869
63	protein targeting to plasma membrane (GO:0072661)	1.99746263
64	peptidyl-glutamic acid carboxylation (GO:0017187)	1.99367417
65	protein carboxylation (GO:0018214)	1.99367417
66	neuronal ion channel clustering (GO:0045161)	1.99135293
67	potassium ion import (GO:0010107)	1.98745087
68	regulation of T-helper 2 cell differentiation (GO:0045628)	1.98592226
69	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	1.97593931
70	phosphate ion transmembrane transport (GO:0035435)	1.97572397
71	skin morphogenesis (GO:0043589)	1.97537851
72	positive regulation of triglyceride lipase activity (GO:0061365)	1.96656095
73	positive regulation of lipoprotein lipase activity (GO:0051006)	1.96656095
74	virion attachment to host cell (GO:0019062)	1.96184012
75	adhesion of symbiont to host cell (GO:0044650)	1.96184012
76	positive regulation of neurotransmitter transport (GO:0051590)	1.95743631
77	positive regulation of lipid catabolic process (GO:0050996)	1.95471467
78	regulation of ARF GTPase activity (GO:0032312)	1.94685698
79	neuromuscular process controlling balance (GO:0050885)	1.94421951
80	response to parathyroid hormone (GO:0071107)	1.93408745
81	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	1.93274027
82	mating behavior (GO:0007617)	1.93095473
83	macroautophagy (GO:0016236)	1.91603758
84	dopamine receptor signaling pathway (GO:0007212)	1.91546090
85	hypotonic response (GO:0006971)	1.91076891
86	negative regulation of fibrinolysis (GO:0051918)	1.90803320
87	actin filament polymerization (GO:0030041)	1.90036964
88	neurotransmitter transport (GO:0006836)	1.89637040
89	cellular response to monoamine stimulus (GO:0071868)	1.89028725
90	cellular response to catecholamine stimulus (GO:0071870)	1.89028725
91	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	1.89000041
92	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	1.88177745
93	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	1.88176874
94	ethanol metabolic process (GO:0006067)	1.86155728
95	regulation of cholesterol esterification (GO:0010872)	1.85974494
96	regulation of cellular amide metabolic process (GO:0034248)	1.85587396
97	response to acidic pH (GO:0010447)	1.85486877
98	activation of protein kinase A activity (GO:0034199)	1.84529319
99	transferrin transport (GO:0033572)	1.84348675
100	cell-substrate adherens junction assembly (GO:0007045)	1.82350756

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.51899982
2	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.48067284
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.41486375
4	* LXR_22292898_ChIP-Seq_THP-1_Human	2.35994341
5	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.28085819
6	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.12105598
7	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.09063733
8	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.00436724
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.92718482
10	* KDM2B_26808549_Chip-Seq_K562_Human	1.90590686
11	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.84730575
12	RACK7_27058665_Chip-Seq_MCF-7_Human	1.75457160
13	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.74799635
14	* ELK3_25401928_ChIP-Seq_HUVEC_Human	1.74032028
15	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.70246356
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.68908085
17	DROSHA_22980978_ChIP-Seq_HELA_Human	1.65711362
18	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.59045750
19	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.58341666
20	* KDM2B_26808549_Chip-Seq_DND41_Human	1.55224899
21	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.55164438
22	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.51783672
23	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.51771807
24	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.50232248
25	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.50189757
26	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.49842866
27	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.49408802
28	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.48446094
29	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.47528640
30	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.46622150
31	TCF7_22412390_ChIP-Seq_EML_Mouse	1.46379733
32	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.40772315
33	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.39652398
34	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.36080235
35	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.34463592
36	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.34114987
37	CLOCK_20551151_ChIP-Seq_293T_Human	1.31939462
38	* CTCF_27219007_Chip-Seq_Bcells_Human	1.31320291
39	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.30788463
40	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29490738
41	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.27082966
42	SMC4_20622854_ChIP-Seq_HELA_Human	1.25118505
43	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.24950722
44	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.24188563
45	GATA1_19941826_ChIP-Seq_K562_Human	1.23164546
46	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.23046335
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.22427660
48	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.21520500
49	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.20939271
50	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.20638198
51	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19454964
52	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.19288197
53	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.18533349
54	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.18106824
55	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.18072826
56	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.17868302
57	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.16543522
58	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.14013595
59	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.13511237
60	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.13453924
61	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.13250897
62	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13128995
63	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.12826997
64	P68_20966046_ChIP-Seq_HELA_Human	1.11293818
65	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11273552
66	VDR_21846776_ChIP-Seq_THP-1_Human	1.11201698
67	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.09838595
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09474487
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09118698
70	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07754032
71	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.07551977
72	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.07159296
73	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.06936392
74	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.06936392
75	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.05931213
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.05281250
77	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.04627838
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04468374
79	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.02857362
80	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.02857362
81	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.02832501
82	VDR_24763502_ChIP-Seq_THP-1_Human	1.02373622
83	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.02308678
84	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.02248588
85	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01379244
86	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01195334
87	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.00601372
88	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.00229695
89	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.99972152
90	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.99234506
91	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.96686907
92	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.95565064
93	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94939561
94	* SA1_27219007_Chip-Seq_Bcells_Human	0.94661689
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94470505
96	TP63_22573176_ChIP-Seq_HFKS_Human	0.94246294
97	SPI1_23127762_ChIP-Seq_K562_Human	0.93877573
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92247999
99	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.91925891
100	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.90314014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	3.77195612
2	MP0004270_analgesia	2.81706410
3	MP0003705_abnormal_hypodermis_morpholog	2.69875219
4	MP0009840_abnormal_foam_cell	2.68928631
5	MP0003191_abnormal_cellular_cholesterol	2.68018515
6	MP0003879_abnormal_hair_cell	2.57623558
7	MP0003329_amyloid_beta_deposits	2.50766642
8	MP0009780_abnormal_chondrocyte_physiolo	2.45869605
9	MP0002139_abnormal_hepatobiliary_system	2.30168305
10	MP0005058_abnormal_lysosome_morphology	2.11903590
11	MP0003183_abnormal_peptide_metabolism	2.03872858
12	MP0003303_peritoneal_inflammation	2.01764685
13	MP0003172_abnormal_lysosome_physiology	1.98906139
14	MP0010234_abnormal_vibrissa_follicle	1.98694217
15	MP0003075_altered_response_to	1.97141783
16	MP0005409_darkened_coat_color	1.94476841
17	MP0008438_abnormal_cutaneous_collagen	1.89206926
18	MP0005360_urolithiasis	1.83823634
19	MP0005365_abnormal_bile_salt	1.78459298
20	MP0000604_amyloidosis	1.78244399
21	MP0003635_abnormal_synaptic_transmissio	1.74949959
22	MP0003566_abnormal_cell_adhesion	1.73064791
23	MP0008260_abnormal_autophagy	1.71997533
24	MP0002064_seizures	1.70991904
25	MP0003436_decreased_susceptibility_to	1.56424849
26	MP0001958_emphysema	1.55906064
27	MP0003300_gastrointestinal_ulcer	1.51883308
28	MP0008569_lethality_at_weaning	1.51639758
29	MP0005423_abnormal_somatic_nervous	1.50943064
30	MP0003690_abnormal_glial_cell	1.49298310
31	MP0003880_abnormal_central_pattern	1.44750591
32	MP0003279_aneurysm	1.43475585
33	MP0004510_myositis	1.42319197
34	MP0004130_abnormal_muscle_cell	1.42060573
35	MP0005451_abnormal_body_composition	1.39368633
36	MP0005166_decreased_susceptibility_to	1.38988339
37	MP0008874_decreased_physiological_sensi	1.34645347
38	MP0000920_abnormal_myelination	1.34611577
39	MP0004858_abnormal_nervous_system	1.34251560
40	MP0005085_abnormal_gallbladder_physiolo	1.30639853
41	MP0002063_abnormal_learning/memory/cond	1.30484569
42	MP0002734_abnormal_mechanical_nocicepti	1.29250409
43	MP0005464_abnormal_platelet_physiology	1.24653581
44	MP0010329_abnormal_lipoprotein_level	1.21355152
45	MP0001501_abnormal_sleep_pattern	1.14770228
46	MP0000751_myopathy	1.13745816
47	MP0003091_abnormal_cell_migration	1.13186317
48	MP0001849_ear_inflammation	1.13147585
49	MP0003453_abnormal_keratinocyte_physiol	1.09604504
50	MP0002796_impaired_skin_barrier	1.08658004
51	MP0005275_abnormal_skin_tensile	1.07987647
52	MP0003724_increased_susceptibility_to	1.07933880
53	MP0009745_abnormal_behavioral_response	1.07520181
54	MP0003828_pulmonary_edema	1.06319176
55	MP0001533_abnormal_skeleton_physiology	1.06141966
56	MP0003633_abnormal_nervous_system	1.05284639
57	MP0001666_abnormal_nutrient_absorption	1.02483970
58	MP0005535_abnormal_body_temperature	0.97292889
59	MP0002971_abnormal_brown_adipose	0.96555352
60	MP0003868_abnormal_feces_composition	0.95886948
61	MP0002272_abnormal_nervous_system	0.94790523
62	MP0005165_increased_susceptibility_to	0.94631500
63	MP0006082_CNS_inflammation	0.93794778
64	MP0004019_abnormal_vitamin_homeostasis	0.93632758
65	MP0002118_abnormal_lipid_homeostasis	0.92349482
66	MP0003123_paternal_imprinting	0.91480945
67	MP0002998_abnormal_bone_remodeling	0.89607976
68	MP0004947_skin_inflammation	0.89431754
69	MP0002295_abnormal_pulmonary_circulatio	0.89424489
70	MP0001765_abnormal_ion_homeostasis	0.89204059
71	MP0003634_abnormal_glial_cell	0.89198662
72	MP0005623_abnormal_meninges_morphology	0.87292873
73	MP0005023_abnormal_wound_healing	0.86083318
74	MP0001440_abnormal_grooming_behavior	0.85345964
75	MP0003045_fibrosis	0.84461307
76	MP0002132_abnormal_respiratory_system	0.84353708
77	MP0002572_abnormal_emotion/affect_behav	0.83684413
78	MP0000747_muscle_weakness	0.83592452
79	MP0005257_abnormal_intraocular_pressure	0.77029033
80	MP0002089_abnormal_postnatal_growth/wei	0.76342240
81	MP0001970_abnormal_pain_threshold	0.75106421
82	MP0002896_abnormal_bone_mineralization	0.74216209
83	MP0003866_abnormal_defecation	0.73929258
84	MP0005167_abnormal_blood-brain_barrier	0.72975489
85	MP0002733_abnormal_thermal_nociception	0.72964683
86	MP0001348_abnormal_lacrimal_gland	0.72878482
87	MP0003631_nervous_system_phenotype	0.72831256
88	MP0010155_abnormal_intestine_physiology	0.72730413
89	MP0010368_abnormal_lymphatic_system	0.72202837
90	MP0008875_abnormal_xenobiotic_pharmacok	0.70938642
91	MP0000858_altered_metastatic_potential	0.70582919
92	MP0002133_abnormal_respiratory_system	0.70213830
93	MP0005388_respiratory_system_phenotype	0.70213830
94	MP0002876_abnormal_thyroid_physiology	0.70147993
95	MP0005375_adipose_tissue_phenotype	0.70009677
96	MP0009379_abnormal_foot_pigmentation	0.68563212
97	MP0005666_abnormal_adipose_tissue	0.68473617
98	MP0001542_abnormal_bone_strength	0.67757578
99	MP0008004_abnormal_stomach_pH	0.67084383
100	MP0000343_altered_response_to	0.67019161

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	3.37914176
2	Supranuclear gaze palsy (HP:0000605)	3.29555241
3	Neurofibrillary tangles (HP:0002185)	3.14811347
4	Protrusio acetabuli (HP:0003179)	2.93277251
5	Myokymia (HP:0002411)	2.82107455
6	Ankle clonus (HP:0011448)	2.79127739
7	Cerebral inclusion bodies (HP:0100314)	2.75622424
8	Systemic lupus erythematosus (HP:0002725)	2.55796012
9	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.51887138
10	Deep venous thrombosis (HP:0002625)	2.49460670
11	Distal upper limb amyotrophy (HP:0007149)	2.49349568
12	Upper limb amyotrophy (HP:0009129)	2.49349568
13	Vascular tortuosity (HP:0004948)	2.45908254
14	Torticollis (HP:0000473)	2.45260926
15	Increased variability in muscle fiber diameter (HP:0003557)	2.42312584
16	Diplopia (HP:0000651)	2.38295439
17	Abnormality of binocular vision (HP:0011514)	2.38295439
18	Arterial tortuosity (HP:0005116)	2.35290050
19	Dysostosis multiplex (HP:0000943)	2.34200323
20	Distal lower limb muscle weakness (HP:0009053)	2.31127912
21	Axonal loss (HP:0003447)	2.30392545
22	Mucopolysacchariduria (HP:0008155)	2.29331178
23	Urinary glycosaminoglycan excretion (HP:0003541)	2.29331178
24	Vertebral compression fractures (HP:0002953)	2.28354063
25	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.27328378
26	Abnormality of polysaccharide metabolism (HP:0011012)	2.27328378
27	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.27328378
28	Cerebral aneurysm (HP:0004944)	2.24962076
29	Eczematoid dermatitis (HP:0000976)	2.24400938
30	Type 1 muscle fiber predominance (HP:0003803)	2.21181865
31	Abnormality of skeletal muscle fiber size (HP:0012084)	2.20794027
32	Action tremor (HP:0002345)	2.18896380
33	Hyperparathyroidism (HP:0000843)	2.17594930
34	Abnormality of liposaccharide metabolism (HP:0010968)	2.17349583
35	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.17349583
36	Abnormality of glycolipid metabolism (HP:0010969)	2.17349583
37	Premature rupture of membranes (HP:0001788)	2.17176913
38	Neuronal loss in central nervous system (HP:0002529)	2.15645867
39	Amyloidosis (HP:0011034)	2.14920358
40	Craniofacial dystonia (HP:0012179)	2.12202513
41	Visual hallucinations (HP:0002367)	2.11883766
42	Focal dystonia (HP:0004373)	2.10147749
43	Hand muscle atrophy (HP:0009130)	2.09925908
44	Papilledema (HP:0001085)	2.08876112
45	Depression (HP:0000716)	2.03937578
46	Abnormality of the Achilles tendon (HP:0005109)	2.00509628
47	Mutism (HP:0002300)	2.00202865
48	Mildly elevated creatine phosphokinase (HP:0008180)	2.00112896
49	Purpura (HP:0000979)	1.99409879
50	Xanthomatosis (HP:0000991)	1.99315544
51	Malnutrition (HP:0004395)	1.98353464
52	Increased connective tissue (HP:0009025)	1.98293857
53	Asymmetric septal hypertrophy (HP:0001670)	1.97770007
54	Polycythemia (HP:0001901)	1.97507752
55	Rigidity (HP:0002063)	1.97291696
56	Complement deficiency (HP:0004431)	1.95778266
57	Abnormality of complement system (HP:0005339)	1.95233013
58	Hemorrhage of the eye (HP:0011885)	1.92569776
59	Abnormality of the nasal mucosa (HP:0000433)	1.92022823
60	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.91987302
61	Hypercortisolism (HP:0001578)	1.91812154
62	Achilles tendon contracture (HP:0001771)	1.91013203
63	Ventricular fibrillation (HP:0001663)	1.90279511
64	Aortic aneurysm (HP:0004942)	1.89650418
65	Exercise-induced myalgia (HP:0003738)	1.88460418
66	Annular pancreas (HP:0001734)	1.87265075
67	Postural instability (HP:0002172)	1.86999095
68	Abnormality of macrophages (HP:0004311)	1.86780197
69	Rapidly progressive (HP:0003678)	1.86183825
70	Muscle fiber splitting (HP:0003555)	1.84813934
71	Growth hormone excess (HP:0000845)	1.84483969
72	Mitral stenosis (HP:0001718)	1.83318132
73	Nuclear cataract (HP:0100018)	1.82103370
74	Hyperlipoproteinemia (HP:0010980)	1.81893822
75	Peritonitis (HP:0002586)	1.80949138
76	Hyporeflexia of lower limbs (HP:0002600)	1.80347360
77	Cervical subluxation (HP:0003308)	1.78663680
78	Intention tremor (HP:0002080)	1.77883561
79	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.77409512
80	Tetraplegia (HP:0002445)	1.77306967
81	Hydroxyprolinuria (HP:0003080)	1.75080645
82	Abnormality of proline metabolism (HP:0010907)	1.75080645
83	Focal motor seizures (HP:0011153)	1.74757529
84	Cardiovascular calcification (HP:0011915)	1.74180185
85	Abnormal eating behavior (HP:0100738)	1.73514646
86	Akinesia (HP:0002304)	1.70744996
87	Polygenic inheritance (HP:0010982)	1.70518079
88	Fragile skin (HP:0001030)	1.69882909
89	Dementia (HP:0000726)	1.69359115
90	Broad metatarsal (HP:0001783)	1.69109954
91	Vascular calcification (HP:0004934)	1.68280065
92	Glomerulonephritis (HP:0000099)	1.67586783
93	Distal lower limb amyotrophy (HP:0008944)	1.67428292
94	Thin bony cortex (HP:0002753)	1.67340881
95	Aneurysm (HP:0002617)	1.66734541
96	Difficulty running (HP:0009046)	1.66536848
97	Apathy (HP:0000741)	1.66030213
98	Dysmetria (HP:0001310)	1.65485140
99	Dilatation of the ascending aorta (HP:0005111)	1.65416597
100	Recurrent gram-negative bacterial infections (HP:0005420)	1.64487698

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	2.95704754
2	RIPK1	2.89389305
3	ERN1	2.85212931
4	RIPK4	2.68827056
5	TRIB3	2.25896494
6	EPHA4	2.23082366
7	DAPK2	1.99251852
8	KSR2	1.99150283
9	MAP3K9	1.84310256
10	PAK6	1.83559078
11	ARAF	1.80791769
12	MAP3K11	1.76923082
13	NTRK3	1.68849320
14	SIK1	1.63241797
15	NTRK1	1.56439192
16	MAP3K3	1.53274625
17	MAP3K2	1.50803405
18	TESK1	1.48711213
19	LMTK2	1.45806975
20	MAP3K1	1.44771785
21	MAP3K13	1.35426930
22	PRKD3	1.33628788
23	PDPK1	1.32833546
24	PRKG2	1.30150086
25	MARK2	1.29495306
26	MAP2K3	1.28822746
27	CAMKK1	1.28275341
28	LATS2	1.26079647
29	EPHB1	1.25585922
30	STK38	1.21934135
31	TAOK1	1.19804167
32	TAOK2	1.13349148
33	UHMK1	1.11556511
34	PRKD2	1.10717876
35	EPHA2	1.09047403
36	GRK5	1.06773832
37	MAPK12	1.06748160
38	PDK1	1.04127563
39	MAP3K12	1.02947724
40	PTK2	0.97826677
41	SGK3	0.95487722
42	ICK	0.93424524
43	TYK2	0.92369095
44	MYLK	0.90143899
45	TTN	0.88074766
46	TNK2	0.85114258
47	CDC42BPA	0.84791272
48	BRAF	0.84260777
49	ZAP70	0.83981124
50	PDGFRA	0.81302095
51	TGFBR2	0.80748491
52	PRKCH	0.80715026
53	FES	0.80160911
54	CSK	0.78188035
55	FGFR4	0.77687944
56	SGK494	0.76766646
57	SGK223	0.76766646
58	CAMK1	0.74763757
59	CDK5	0.72382577
60	SMG1	0.72329861
61	PHKG1	0.71635228
62	PHKG2	0.71635228
63	PTK6	0.70820214
64	DMPK	0.70230623
65	RPS6KA2	0.69267171
66	MINK1	0.68693238
67	GRK6	0.67839756
68	TBK1	0.63462071
69	IRAK3	0.63176450
70	JAK1	0.62637015
71	LIMK1	0.61236216
72	DYRK1B	0.61016390
73	RET	0.60900387
74	SIK2	0.60177680
75	STK11	0.58553555
76	CDK19	0.58521467
77	DAPK3	0.58364861
78	BMX	0.57760838
79	DDR2	0.57482844
80	FGFR3	0.57285423
81	ABL2	0.56901432
82	MAP4K1	0.55651432
83	SGK2	0.55559195
84	MOS	0.54437724
85	PAK4	0.53998540
86	MAP2K1	0.53033768
87	ROCK2	0.52622268
88	IRAK2	0.51150946
89	LRRK2	0.50543202
90	EPHB2	0.50250519
91	CAMK2G	0.49922526
92	MAP2K4	0.49411141
93	JAK2	0.49062624
94	MAP3K6	0.47654419
95	PTK2B	0.47456086
96	FYN	0.47410557
97	SIK3	0.46397072
98	KSR1	0.45203984
99	TYRO3	0.44520183
100	MAP2K6	0.44485166

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.28471150
2	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.11599585
3	Long-term potentiation_Homo sapiens_hsa04720	1.84899394
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.82794866
5	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.44570662
6	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.34608524
7	GnRH signaling pathway_Homo sapiens_hsa04912	1.29530147
8	Bile secretion_Homo sapiens_hsa04976	1.27325909
9	Insulin secretion_Homo sapiens_hsa04911	1.24258300
10	Amphetamine addiction_Homo sapiens_hsa05031	1.23837936
11	Other glycan degradation_Homo sapiens_hsa00511	1.23688799
12	Prion diseases_Homo sapiens_hsa05020	1.20914546
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.14519507
14	Gastric acid secretion_Homo sapiens_hsa04971	1.13994638
15	VEGF signaling pathway_Homo sapiens_hsa04370	1.13073050
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.11497981
17	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.10846487
18	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.09264461
19	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.08255481
20	Histidine metabolism_Homo sapiens_hsa00340	1.07832338
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.04286756
22	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.02332066
23	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.01619300
24	PPAR signaling pathway_Homo sapiens_hsa03320	0.99849988
25	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.98601660
26	Vibrio cholerae infection_Homo sapiens_hsa05110	0.98435869
27	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.98035616
28	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.97363717
29	Amoebiasis_Homo sapiens_hsa05146	0.97076269
30	Renin secretion_Homo sapiens_hsa04924	0.95134677
31	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.94302066
32	Glioma_Homo sapiens_hsa05214	0.93290295
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.92567448
34	Complement and coagulation cascades_Homo sapiens_hsa04610	0.92034689
35	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.91472434
36	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.90760731
37	Endocytosis_Homo sapiens_hsa04144	0.90728689
38	Cocaine addiction_Homo sapiens_hsa05030	0.90562240
39	Estrogen signaling pathway_Homo sapiens_hsa04915	0.88705202
40	Dopaminergic synapse_Homo sapiens_hsa04728	0.87902079
41	Circadian entrainment_Homo sapiens_hsa04713	0.87820279
42	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.87186145
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84378122
44	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.84031917
45	Cholinergic synapse_Homo sapiens_hsa04725	0.84026174
46	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.80907812
47	Lysosome_Homo sapiens_hsa04142	0.80677469
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.80574355
49	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.79884528
50	Mineral absorption_Homo sapiens_hsa04978	0.78998219
51	Osteoclast differentiation_Homo sapiens_hsa04380	0.76590557
52	Insulin signaling pathway_Homo sapiens_hsa04910	0.76484686
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.76323462
54	Renal cell carcinoma_Homo sapiens_hsa05211	0.76037901
55	Pancreatic secretion_Homo sapiens_hsa04972	0.75770917
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75336497
57	GABAergic synapse_Homo sapiens_hsa04727	0.74723753
58	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.73289341
59	ErbB signaling pathway_Homo sapiens_hsa04012	0.71752542
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70713689
61	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70061988
62	Glucagon signaling pathway_Homo sapiens_hsa04922	0.69692372
63	Focal adhesion_Homo sapiens_hsa04510	0.68951017
64	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68617664
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67281085
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.67279375
67	Non-small cell lung cancer_Homo sapiens_hsa05223	0.65466180
68	Long-term depression_Homo sapiens_hsa04730	0.65078739
69	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.64482812
70	Salivary secretion_Homo sapiens_hsa04970	0.64337751
71	Morphine addiction_Homo sapiens_hsa05032	0.64046329
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63418426
73	Rap1 signaling pathway_Homo sapiens_hsa04015	0.63041550
74	Acute myeloid leukemia_Homo sapiens_hsa05221	0.62068187
75	Insulin resistance_Homo sapiens_hsa04931	0.61809856
76	Choline metabolism in cancer_Homo sapiens_hsa05231	0.61786952
77	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.61478648
78	Endometrial cancer_Homo sapiens_hsa05213	0.61091087
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.60933736
80	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.60909763
81	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.60741128
82	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.59255476
83	Gap junction_Homo sapiens_hsa04540	0.59024772
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.58390916
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.57435092
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57291186
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56934198
88	AMPK signaling pathway_Homo sapiens_hsa04152	0.55836561
89	Melanogenesis_Homo sapiens_hsa04916	0.55688767
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55321445
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55174345
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.54466994
93	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.53781043
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53487944
95	mTOR signaling pathway_Homo sapiens_hsa04150	0.52761342
96	Tuberculosis_Homo sapiens_hsa05152	0.52316175
97	Nicotine addiction_Homo sapiens_hsa05033	0.51938504
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51891080
99	Platelet activation_Homo sapiens_hsa04611	0.51792661
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.50679818

TPRG1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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