TPRXL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.46673497
2multicellular organism reproduction (GO:0032504)8.70717966
3piRNA metabolic process (GO:0034587)7.64806578
4oocyte development (GO:0048599)7.02921690
5DNA methylation involved in gamete generation (GO:0043046)6.77070832
6regulation of meiosis I (GO:0060631)6.70500622
7regulation of DNA methylation (GO:0044030)6.67922459
8retinal cone cell development (GO:0046549)6.17710462
9meiotic cell cycle (GO:0051321)6.11493769
10protein kinase C signaling (GO:0070528)5.81361432
11reproduction (GO:0000003)5.68640909
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51187514
13negative regulation of reproductive process (GO:2000242)5.38800186
14positive regulation of humoral immune response (GO:0002922)5.31546808
15female gamete generation (GO:0007292)5.18016095
16positive regulation of histone H3-K4 methylation (GO:0051571)5.09597757
17binding of sperm to zona pellucida (GO:0007339)4.65104806
18gene silencing by RNA (GO:0031047)4.62103280
19regulation of histone H3-K9 methylation (GO:0051570)4.47691391
20regulation of steroid hormone secretion (GO:2000831)4.43147527
21glycine transport (GO:0015816)4.40229010
22centriole replication (GO:0007099)4.37330384
23sperm-egg recognition (GO:0035036)4.35030078
24fertilization (GO:0009566)4.32209119
25single fertilization (GO:0007338)4.25170595
26regulation of calcium ion-dependent exocytosis (GO:0017158)4.07227882
27DNA methylation (GO:0006306)3.79005330
28DNA alkylation (GO:0006305)3.79005330
29male meiosis (GO:0007140)3.77495940
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77014753
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77014753
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.77014753
33synapsis (GO:0007129)3.66618049
34cilium or flagellum-dependent cell motility (GO:0001539)3.64544754
35positive regulation of reproductive process (GO:2000243)3.59909680
36male meiosis I (GO:0007141)3.57451619
37cell-cell recognition (GO:0009988)3.56727187
38citrulline biosynthetic process (GO:0019240)3.55094504
39positive regulation of gastrulation (GO:2000543)3.52756998
40interkinetic nuclear migration (GO:0022027)3.48776700
41negative regulation of cAMP-mediated signaling (GO:0043951)3.45822273
42regulation of hypersensitivity (GO:0002883)3.45302951
43negative regulation of histone methylation (GO:0031061)3.42415533
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42052002
45positive regulation of meiosis (GO:0045836)3.27370886
46regulation of cell maturation (GO:1903429)3.25425972
47positive regulation of uterine smooth muscle contraction (GO:0070474)3.21824141
48regulation of phospholipid biosynthetic process (GO:0071071)3.18534495
49DNA methylation or demethylation (GO:0044728)3.17832468
50regulation of reproductive process (GO:2000241)3.15966758
51phosphorelay signal transduction system (GO:0000160)3.14399765
52positive regulation of histone methylation (GO:0031062)3.12048823
53positive regulation of meiotic cell cycle (GO:0051446)3.08481458
54detection of light stimulus involved in sensory perception (GO:0050962)3.07297521
55detection of light stimulus involved in visual perception (GO:0050908)3.07297521
56protein K11-linked deubiquitination (GO:0035871)3.01581715
57gene silencing (GO:0016458)2.98484682
58regulation of meiosis (GO:0040020)2.97448198
59epithelial cilium movement (GO:0003351)2.97034503
60chromosome organization involved in meiosis (GO:0070192)2.96524665
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95398499
62somite rostral/caudal axis specification (GO:0032525)2.94534763
63meiotic nuclear division (GO:0007126)2.92948222
64regulation of histone H3-K4 methylation (GO:0051569)2.92345319
65centriole assembly (GO:0098534)2.89884574
66oxidative demethylation (GO:0070989)2.89518985
67photoreceptor cell maintenance (GO:0045494)2.88951474
68positive regulation of steroid hormone secretion (GO:2000833)2.88122871
69meiosis I (GO:0007127)2.85698632
70cilium movement (GO:0003341)2.84678098
71synaptonemal complex assembly (GO:0007130)2.84195473
72DNA modification (GO:0006304)2.81890175
73tachykinin receptor signaling pathway (GO:0007217)2.80493255
74N-terminal protein amino acid acetylation (GO:0006474)2.77134754
75meiotic cell cycle process (GO:1903046)2.76565532
76positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.74683498
77synaptonemal complex organization (GO:0070193)2.73950923
78microtubule severing (GO:0051013)2.72677816
79attachment of spindle microtubules to kinetochore (GO:0008608)2.71127038
80microtubule polymerization or depolymerization (GO:0031109)2.71021078
81positive regulation of chromosome segregation (GO:0051984)2.67872645
82regulation of corticosteroid hormone secretion (GO:2000846)2.64531321
83negative regulation of execution phase of apoptosis (GO:1900118)2.63471991
84oogenesis (GO:0048477)2.60638170
85negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59764432
86translesion synthesis (GO:0019985)2.56552707
87primitive streak formation (GO:0090009)2.56535555
88DNA replication-dependent nucleosome assembly (GO:0006335)2.54119170
89DNA replication-dependent nucleosome organization (GO:0034723)2.54119170
90regulation of chromatin silencing (GO:0031935)2.52163952
91L-fucose catabolic process (GO:0042355)2.51603861
92fucose catabolic process (GO:0019317)2.51603861
93L-fucose metabolic process (GO:0042354)2.51603861
94histone H3-K4 trimethylation (GO:0080182)2.49854706
95neural tube formation (GO:0001841)2.49239603
96regulation of meiotic cell cycle (GO:0051445)2.48134017
97protein polyglutamylation (GO:0018095)2.47775548
98regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.47169149
99histone H3-K9 methylation (GO:0051567)2.46631978
100regulation of acrosome reaction (GO:0060046)10.3391514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.91016320
2GBX2_23144817_ChIP-Seq_PC3_Human3.20019697
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02604640
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01073764
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.85595121
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63400713
7ZNF274_21170338_ChIP-Seq_K562_Hela2.33571376
8VDR_22108803_ChIP-Seq_LS180_Human2.25234250
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20097170
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10791377
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98367685
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98212647
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97916496
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91361719
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.90531503
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89013281
17P300_19829295_ChIP-Seq_ESCs_Human1.85322023
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82591302
19TAF15_26573619_Chip-Seq_HEK293_Human1.77276511
20SMAD4_21799915_ChIP-Seq_A2780_Human1.75661125
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74176252
22STAT3_23295773_ChIP-Seq_U87_Human1.71173669
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71087863
24CBP_20019798_ChIP-Seq_JUKART_Human1.71087863
25EWS_26573619_Chip-Seq_HEK293_Human1.70602317
26TCF4_23295773_ChIP-Seq_U87_Human1.68810307
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65743057
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65473178
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65157616
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64476657
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.62629404
32IGF1R_20145208_ChIP-Seq_DFB_Human1.61042811
33AR_25329375_ChIP-Seq_VCAP_Human1.59517218
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59089841
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58778889
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58778889
37ER_23166858_ChIP-Seq_MCF-7_Human1.56261890
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56159594
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53945593
40FUS_26573619_Chip-Seq_HEK293_Human1.53537292
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48405315
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.45902702
43BCAT_22108803_ChIP-Seq_LS180_Human1.44247996
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.43368218
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.40566560
46RUNX2_22187159_ChIP-Seq_PCA_Human1.40300372
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39768550
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37515259
49* SMAD4_21741376_ChIP-Seq_EPCs_Human1.36008883
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32783262
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28890078
52TCF4_22108803_ChIP-Seq_LS180_Human1.28318819
53IRF1_19129219_ChIP-ChIP_H3396_Human1.20937206
54TP53_22573176_ChIP-Seq_HFKS_Human1.20561419
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20049848
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19203083
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18552372
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17930408
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17010178
60CDX2_22108803_ChIP-Seq_LS180_Human1.16705248
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16397987
62SOX2_19829295_ChIP-Seq_ESCs_Human1.13995696
63NANOG_19829295_ChIP-Seq_ESCs_Human1.13995696
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13749349
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.12242266
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10192670
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.09395317
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07993525
69AHR_22903824_ChIP-Seq_MCF-7_Human1.05573951
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04157686
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.03331274
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01904489
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.01750105
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.01728031
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.01001097
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00974645
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.00974645
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00919555
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.00893205
80TP53_16413492_ChIP-PET_HCT116_Human1.00334201
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99899436
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.98630187
83REST_21632747_ChIP-Seq_MESCs_Mouse0.98071090
84ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95621400
85SMRT_27268052_Chip-Seq_Bcells_Human0.95365895
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95285527
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.94945948
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94263632
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.93929307
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93262643
91NCOR_22424771_ChIP-Seq_293T_Human0.92830433
92AR_21572438_ChIP-Seq_LNCaP_Human0.92641029
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91883306
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.91696164
95KDM2B_26808549_Chip-Seq_REH_Human0.91635663
96AR_20517297_ChIP-Seq_VCAP_Human0.91603848
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91277857
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.90450229
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89574411
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89352701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.03272363
2MP0008877_abnormal_DNA_methylation4.37899568
3MP0006292_abnormal_olfactory_placode3.88457448
4MP0008057_abnormal_DNA_replication3.18331682
5MP0008789_abnormal_olfactory_epithelium3.08896328
6MP0005395_other_phenotype3.01740500
7MP0002138_abnormal_hepatobiliary_system2.85432242
8MP0005394_taste/olfaction_phenotype2.57308954
9MP0005499_abnormal_olfactory_system2.57308954
10MP0002234_abnormal_pharynx_morphology2.50842718
11MP0003890_abnormal_embryonic-extraembry2.50245716
12MP0003950_abnormal_plasma_membrane2.32962704
13MP0001929_abnormal_gametogenesis2.27528441
14MP0005646_abnormal_pituitary_gland2.20105012
15MP0005551_abnormal_eye_electrophysiolog2.11577659
16MP0005410_abnormal_fertilization2.09332374
17MP0003699_abnormal_female_reproductive2.05473684
18MP0000569_abnormal_digit_pigmentation1.94125811
19MP0000427_abnormal_hair_cycle1.92936417
20MP0002210_abnormal_sex_determination1.88543477
21MP0008058_abnormal_DNA_repair1.88251665
22MP0003195_calcinosis1.76476445
23MP0002139_abnormal_hepatobiliary_system1.75742569
24MP0000653_abnormal_sex_gland1.70803242
25MP0001984_abnormal_olfaction1.70774298
26MP0005360_urolithiasis1.64719306
27MP0006276_abnormal_autonomic_nervous1.59823949
28MP0003879_abnormal_hair_cell1.59679514
29MP0003136_yellow_coat_color1.54886451
30MP0000372_irregular_coat_pigmentation1.53306490
31MP0000631_abnormal_neuroendocrine_gland1.53005991
32MP0001119_abnormal_female_reproductive1.49133406
33MP0003252_abnormal_bile_duct1.46423217
34MP0002161_abnormal_fertility/fecundity1.45909977
35MP0002102_abnormal_ear_morphology1.44878336
36MP0003698_abnormal_male_reproductive1.38242279
37MP0003646_muscle_fatigue1.38196797
38MP0003880_abnormal_central_pattern1.37682604
39MP0002272_abnormal_nervous_system1.35622119
40MP0010094_abnormal_chromosome_stability1.35233909
41MP0003693_abnormal_embryo_hatching1.31492824
42MP0001986_abnormal_taste_sensitivity1.29803569
43MP0005174_abnormal_tail_pigmentation1.28591525
44MP0001501_abnormal_sleep_pattern1.27567015
45MP0005647_abnormal_sex_gland1.27062993
46MP0004142_abnormal_muscle_tone1.26924288
47MP0005389_reproductive_system_phenotype1.22816916
48MP0001145_abnormal_male_reproductive1.22421818
49MP0001968_abnormal_touch/_nociception1.21125340
50MP0003121_genomic_imprinting1.16688168
51MP0000015_abnormal_ear_pigmentation1.13471103
52MP0004043_abnormal_pH_regulation1.11755623
53MP0000383_abnormal_hair_follicle1.10280544
54MP0005085_abnormal_gallbladder_physiolo1.10022421
55MP0010678_abnormal_skin_adnexa1.09717891
56MP0001486_abnormal_startle_reflex1.08855789
57MP0005075_abnormal_melanosome_morpholog1.07716757
58MP0002160_abnormal_reproductive_system1.05839353
59MP0005253_abnormal_eye_physiology1.05535737
60MP0001293_anophthalmia1.03633920
61MP0009745_abnormal_behavioral_response1.02387763
62MP0002735_abnormal_chemical_nociception1.00310913
63MP0002736_abnormal_nociception_after0.99730491
64MP0010030_abnormal_orbit_morphology0.95731095
65MP0003119_abnormal_digestive_system0.94887949
66MP0003183_abnormal_peptide_metabolism0.93666763
67MP0002233_abnormal_nose_morphology0.91608321
68MP0005645_abnormal_hypothalamus_physiol0.91153280
69MP0001324_abnormal_eye_pigmentation0.90278305
70MP0001664_abnormal_digestion0.87575772
71MP0003077_abnormal_cell_cycle0.87188907
72MP0010368_abnormal_lymphatic_system0.86946364
73MP0001919_abnormal_reproductive_system0.86004644
74MP0009046_muscle_twitch0.82825024
75MP0002095_abnormal_skin_pigmentation0.80902435
76MP0006072_abnormal_retinal_apoptosis0.80763944
77MP0001963_abnormal_hearing_physiology0.80632835
78MP0002229_neurodegeneration0.77752952
79MP0002638_abnormal_pupillary_reflex0.77284737
80MP0010307_abnormal_tumor_latency0.76222398
81MP0002928_abnormal_bile_duct0.75145620
82MP0004924_abnormal_behavior0.74430365
83MP0005386_behavior/neurological_phenoty0.74430365
84MP0002572_abnormal_emotion/affect_behav0.71483333
85MP0002067_abnormal_sensory_capabilities0.70761961
86MP0002653_abnormal_ependyma_morphology0.70224368
87MP0008995_early_reproductive_senescence0.69199287
88MP0002090_abnormal_vision0.66426677
89MP0008875_abnormal_xenobiotic_pharmacok0.65362840
90MP0002557_abnormal_social/conspecific_i0.64510059
91MP0004147_increased_porphyrin_level0.64112328
92MP0010234_abnormal_vibrissa_follicle0.63985934
93MP0001485_abnormal_pinna_reflex0.61096039
94MP0002751_abnormal_autonomic_nervous0.60415717
95MP0003635_abnormal_synaptic_transmissio0.59933230
96MP0000647_abnormal_sebaceous_gland0.59154183
97MP0002163_abnormal_gland_morphology0.58807692
98MP0002734_abnormal_mechanical_nocicepti0.58476951
99MP0005195_abnormal_posterior_eye0.56049840
100MP0003787_abnormal_imprinting0.55314414

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)4.65072860
2Hypoplasia of the fovea (HP:0007750)4.65072860
3Supernumerary spleens (HP:0009799)3.87496139
4Abnormality of the fovea (HP:0000493)3.86204762
5Anterior segment dysgenesis (HP:0007700)3.67515390
6Pancreatic cysts (HP:0001737)3.46130003
7Gaze-evoked nystagmus (HP:0000640)3.41841907
8Abnormality of midbrain morphology (HP:0002418)3.38134112
9Molar tooth sign on MRI (HP:0002419)3.38134112
10Abnormality of abdominal situs (HP:0011620)3.29909744
11Abdominal situs inversus (HP:0003363)3.29909744
12Attenuation of retinal blood vessels (HP:0007843)3.23897993
13Pancreatic fibrosis (HP:0100732)3.21880021
14Impulsivity (HP:0100710)3.21463619
15Fair hair (HP:0002286)3.20473666
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.16729185
17Oligodactyly (hands) (HP:0001180)3.11592154
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.07788570
19Aplasia/Hypoplasia of the tongue (HP:0010295)3.07187059
20Abnormal ciliary motility (HP:0012262)2.96709912
21Aplasia/Hypoplasia of the macula (HP:0008059)2.94056187
22Abnormality of the renal cortex (HP:0011035)2.92887452
23Congenital sensorineural hearing impairment (HP:0008527)2.90668096
24Chronic hepatic failure (HP:0100626)2.88758751
25Chromsome breakage (HP:0040012)2.87301812
26Papillary thyroid carcinoma (HP:0002895)2.86110816
27Lip pit (HP:0100267)2.76897861
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72066448
29Gonadotropin excess (HP:0000837)2.71742249
30Abnormality of the labia minora (HP:0012880)2.69446015
31Aplasia/Hypoplasia affecting the retina (HP:0008061)2.67623468
32Azoospermia (HP:0000027)2.67378525
33Hypophosphatemic rickets (HP:0004912)2.64577745
34Facial hemangioma (HP:0000329)2.62024507
35Median cleft lip (HP:0000161)2.60861261
36True hermaphroditism (HP:0010459)2.60557116
37Short tibia (HP:0005736)2.59851920
38Osteomalacia (HP:0002749)2.58840486
39Abnormality of the renal medulla (HP:0100957)2.58769889
40Abnormal biliary tract physiology (HP:0012439)2.57255146
41Bile duct proliferation (HP:0001408)2.57255146
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.55585663
43Absent/shortened dynein arms (HP:0200106)2.55585663
44Infertility (HP:0000789)2.54808524
45Medial flaring of the eyebrow (HP:0010747)2.54657566
46Nephronophthisis (HP:0000090)2.54124945
47Tubulointerstitial nephritis (HP:0001970)2.52055392
48Progressive cerebellar ataxia (HP:0002073)2.50145869
49Abnormal respiratory motile cilium physiology (HP:0012261)2.48913482
50Decreased circulating renin level (HP:0003351)2.46761491
51Hyperventilation (HP:0002883)2.41289616
52Bony spicule pigmentary retinopathy (HP:0007737)2.40881159
53Septo-optic dysplasia (HP:0100842)2.38902166
54Renal cortical cysts (HP:0000803)2.34042291
55Generalized hypopigmentation of hair (HP:0011358)2.33551923
56Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.26781674
57Cystic liver disease (HP:0006706)2.21273657
58Optic nerve hypoplasia (HP:0000609)2.18538751
59Decreased central vision (HP:0007663)2.18459977
60Severe visual impairment (HP:0001141)2.17549680
61Abnormality of macular pigmentation (HP:0008002)2.15452305
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.13518378
63Abnormal spermatogenesis (HP:0008669)2.09530627
64Pendular nystagmus (HP:0012043)2.09081666
65Congenital stationary night blindness (HP:0007642)2.07270798
66Male infertility (HP:0003251)2.06776307
67Rhinitis (HP:0012384)2.04003076
68Genetic anticipation (HP:0003743)2.02652758
69Abnormal respiratory motile cilium morphology (HP:0005938)2.01672377
70Abnormal respiratory epithelium morphology (HP:0012253)2.01672377
71Oligodactyly (HP:0012165)2.01524298
72Cone-rod dystrophy (HP:0000548)2.01120988
73Anencephaly (HP:0002323)1.98554326
74Truncal obesity (HP:0001956)1.98430580
75Type II lissencephaly (HP:0007260)1.97310881
76Preaxial hand polydactyly (HP:0001177)1.95565090
77Congenital hepatic fibrosis (HP:0002612)1.95411908
78Tubulointerstitial abnormality (HP:0001969)1.94615634
79Hypergonadotropic hypogonadism (HP:0000815)1.92582509
80Methylmalonic acidemia (HP:0002912)1.92519781
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92458329
82Proximal tubulopathy (HP:0000114)1.91961869
83Dysdiadochokinesis (HP:0002075)1.90597699
84Abnormality of chromosome stability (HP:0003220)1.89669037
85Progressive inability to walk (HP:0002505)1.87987265
86Absent septum pellucidum (HP:0001331)1.87618658
87Tubular atrophy (HP:0000092)1.86605857
88Congenital primary aphakia (HP:0007707)1.86540182
89Hypoplastic labia majora (HP:0000059)1.83308046
90Gait imbalance (HP:0002141)1.82658797
91Central scotoma (HP:0000603)1.81835941
92Limb hypertonia (HP:0002509)1.80231521
93Genital tract atresia (HP:0001827)1.80153025
94Febrile seizures (HP:0002373)1.79631063
95Thyroid carcinoma (HP:0002890)1.77698391
96Premature ovarian failure (HP:0008209)1.76178315
97Clubbing of toes (HP:0100760)1.75772361
98Nephrogenic diabetes insipidus (HP:0009806)1.74109184
99Abnormal rod and cone electroretinograms (HP:0008323)1.73218350
100Meckel diverticulum (HP:0002245)1.72429998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86301263
2TAOK33.35788889
3MAP3K93.03624367
4BMPR1B2.87525841
5TRIM282.75083017
6MAP3K132.50166291
7ARAF2.34201143
8TNIK2.26848901
9NUAK12.21821915
10NEK62.14792298
11ACVR1B2.04719658
12ZAK1.85144953
13MAPK131.73490241
14STK31.67828463
15MAP4K21.65266446
16EIF2AK31.61449170
17MET1.56604597
18TTK1.53471080
19STK241.48671717
20MST41.43886354
21WNK31.43802837
22MAP3K41.40259381
23TGFBR11.38051711
24EPHA41.35623779
25ADRBK21.33855794
26TNK21.32892063
27STK391.29850815
28INSRR1.28352248
29NTRK21.28132243
30CDK91.24557009
31CDK121.21086095
32AURKA1.19848549
33NTRK31.18985730
34OXSR11.16933367
35GRK11.12737612
36PRKCI1.09616398
37BRAF1.08957038
38STK38L1.08829798
39CSNK1G11.05929370
40MELK1.00030637
41PINK10.99981687
42LATS10.98753421
43PLK10.93326801
44CASK0.92961528
45RAF10.89190288
46PLK40.89189896
47MARK30.88806141
48PKN10.88391496
49MAPKAPK30.83629417
50CSNK1G30.83368365
51BRSK20.82526465
52TIE10.80220974
53CDC70.79771515
54WNK40.79637684
55CSNK1A1L0.78840701
56PIK3CG0.78138687
57CDK80.76659225
58BRD40.74369784
59CSNK1G20.73044611
60CSNK1D0.70111815
61PTK2B0.69544335
62FER0.69411895
63PLK20.68368914
64ATM0.67146792
65CDK70.65823831
66PLK30.62877387
67PRKCE0.62872679
68CAMK2A0.62282155
69MOS0.59839715
70KSR10.58204776
71WNK10.58179401
72CHEK10.56225644
73PRKAA20.54883126
74STK380.54585908
75PRKG10.53637176
76ERBB30.53523866
77TRPM70.51730520
78CHEK20.51393380
79MAP3K70.51144437
80AKT30.50842634
81FLT30.48871708
82TLK10.48607822
83CAMK10.47796369
84CDK190.47371178
85BCR0.46504170
86BRSK10.45400256
87VRK10.45032731
88PIM10.44795966
89PRKACA0.44732413
90PRKCZ0.44473771
91MARK10.43250544
92CDK20.42366614
93NEK20.41085031
94PBK0.39942388
95PRKAA10.38906647
96CAMK40.38899986
97MKNK20.38538629
98TEC0.38184815
99CAMK1G0.37747244
100CAMK1D0.37679442

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.74153887
2Ovarian steroidogenesis_Homo sapiens_hsa049133.33246799
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.17765345
4Phototransduction_Homo sapiens_hsa047442.93982847
5Homologous recombination_Homo sapiens_hsa034402.57154303
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.55028363
7Caffeine metabolism_Homo sapiens_hsa002322.51883740
8Fanconi anemia pathway_Homo sapiens_hsa034602.34601821
9Dorso-ventral axis formation_Homo sapiens_hsa043202.31402720
10Olfactory transduction_Homo sapiens_hsa047402.19609078
11ABC transporters_Homo sapiens_hsa020102.13797525
12Cell cycle_Homo sapiens_hsa041102.11687114
13Oocyte meiosis_Homo sapiens_hsa041142.01889669
14Nicotine addiction_Homo sapiens_hsa050331.91382972
15RNA degradation_Homo sapiens_hsa030181.88420574
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81418737
17Butanoate metabolism_Homo sapiens_hsa006501.79248604
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79019384
19Circadian rhythm_Homo sapiens_hsa047101.75548421
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73546551
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.70227664
22Linoleic acid metabolism_Homo sapiens_hsa005911.68699881
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68514878
24Propanoate metabolism_Homo sapiens_hsa006401.67123364
25Taste transduction_Homo sapiens_hsa047421.63244191
26Mismatch repair_Homo sapiens_hsa034301.61669292
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49090831
28Morphine addiction_Homo sapiens_hsa050321.40470919
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39462082
30Base excision repair_Homo sapiens_hsa034101.30789020
31GABAergic synapse_Homo sapiens_hsa047271.27577979
32RNA polymerase_Homo sapiens_hsa030201.25415777
33Ether lipid metabolism_Homo sapiens_hsa005651.10550120
34Tryptophan metabolism_Homo sapiens_hsa003801.07040630
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06918245
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05436848
37Nucleotide excision repair_Homo sapiens_hsa034201.04859264
38Nitrogen metabolism_Homo sapiens_hsa009101.03978146
39Serotonergic synapse_Homo sapiens_hsa047261.03441370
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01611599
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.99785895
42RNA transport_Homo sapiens_hsa030130.99380378
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.96679004
44p53 signaling pathway_Homo sapiens_hsa041150.95023860
45Non-homologous end-joining_Homo sapiens_hsa034500.94853098
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94586102
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90929812
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90809660
49Retinol metabolism_Homo sapiens_hsa008300.88726651
50Circadian entrainment_Homo sapiens_hsa047130.86170811
51Chemical carcinogenesis_Homo sapiens_hsa052040.83759871
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.79660223
53Inositol phosphate metabolism_Homo sapiens_hsa005620.77857900
54Lysine degradation_Homo sapiens_hsa003100.77297730
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76641494
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75671304
57Glutamatergic synapse_Homo sapiens_hsa047240.75631315
58Regulation of autophagy_Homo sapiens_hsa041400.75427720
59Purine metabolism_Homo sapiens_hsa002300.72924267
60Gap junction_Homo sapiens_hsa045400.69956434
61Long-term depression_Homo sapiens_hsa047300.69194194
62Salivary secretion_Homo sapiens_hsa049700.69149185
63Calcium signaling pathway_Homo sapiens_hsa040200.68495590
64beta-Alanine metabolism_Homo sapiens_hsa004100.61561684
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60941370
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60760708
67Glycerolipid metabolism_Homo sapiens_hsa005610.59458280
68Fatty acid elongation_Homo sapiens_hsa000620.58836569
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57893234
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56691956
71Sphingolipid metabolism_Homo sapiens_hsa006000.54457420
72Histidine metabolism_Homo sapiens_hsa003400.52897417
73TGF-beta signaling pathway_Homo sapiens_hsa043500.52659865
74Insulin secretion_Homo sapiens_hsa049110.52312257
75Arachidonic acid metabolism_Homo sapiens_hsa005900.52292385
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51699291
77Peroxisome_Homo sapiens_hsa041460.51440161
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51044030
79Selenocompound metabolism_Homo sapiens_hsa004500.50874418
80Bile secretion_Homo sapiens_hsa049760.49310204
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47971253
82Folate biosynthesis_Homo sapiens_hsa007900.45611903
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43396912
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42484462
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42452144
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.41728609
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.41064072
88Oxytocin signaling pathway_Homo sapiens_hsa049210.41040642
89cAMP signaling pathway_Homo sapiens_hsa040240.39007558
90mRNA surveillance pathway_Homo sapiens_hsa030150.37846136
91Metabolic pathways_Homo sapiens_hsa011000.36156316
92Arginine and proline metabolism_Homo sapiens_hsa003300.31810131
93Fatty acid biosynthesis_Homo sapiens_hsa000610.30714298
94Dopaminergic synapse_Homo sapiens_hsa047280.29431689
95Gastric acid secretion_Homo sapiens_hsa049710.29316466
96Cholinergic synapse_Homo sapiens_hsa047250.28987632
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28576084
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26523553
99FoxO signaling pathway_Homo sapiens_hsa040680.26385453
100Protein export_Homo sapiens_hsa030600.25797965

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