TPSB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)9.72215628
2regulation of mast cell degranulation (GO:0043304)9.64345114
3leukotriene biosynthetic process (GO:0019370)9.49773541
4positive regulation of regulated secretory pathway (GO:1903307)9.41460546
5regulation of mast cell activation involved in immune response (GO:0033006)9.11990077
6positive regulation of megakaryocyte differentiation (GO:0045654)8.95298966
7production of molecular mediator involved in inflammatory response (GO:0002532)8.25634812
8positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)7.65254604
9regulation of myeloid leukocyte mediated immunity (GO:0002886)7.32401454
10regulation of leukocyte degranulation (GO:0043300)7.03240740
11regulation of mast cell activation (GO:0033003)6.95594624
12peptide hormone processing (GO:0016486)6.76444405
13leukotriene metabolic process (GO:0006691)6.02703994
14regulation of regulated secretory pathway (GO:1903305)5.91717356
15serotonin metabolic process (GO:0042428)5.78663178
16regulation of inflammatory response to antigenic stimulus (GO:0002861)5.46884733
17tyrosine phosphorylation of STAT protein (GO:0007260)5.30416803
18cytokine biosynthetic process (GO:0042089)5.27472260
19regulation of cellular extravasation (GO:0002691)5.25143448
20monoamine transport (GO:0015844)5.25133005
21positive regulation of chemokine secretion (GO:0090197)5.12561955
22positive regulation of acute inflammatory response (GO:0002675)5.12028954
23cytokine metabolic process (GO:0042107)5.02944224
24positive regulation of respiratory burst (GO:0060267)4.98005802
25primary amino compound metabolic process (GO:1901160)4.85817586
26glomerular filtration (GO:0003094)4.73692818
27complement activation, classical pathway (GO:0006958)4.54805820
28thrombin receptor signaling pathway (GO:0070493)4.53620553
29antimicrobial humoral response (GO:0019730)4.52013209
30antibacterial humoral response (GO:0019731)4.37184108
31positive regulation of immunoglobulin mediated immune response (GO:0002891)4.36680550
32positive regulation of B cell mediated immunity (GO:0002714)4.36680550
33positive regulation of calcium-mediated signaling (GO:0050850)4.25806659
34regulation of dendritic cell antigen processing and presentation (GO:0002604)4.22885001
35fatty acid derivative biosynthetic process (GO:1901570)4.20749041
36icosanoid biosynthetic process (GO:0046456)4.20749041
37renal filtration (GO:0097205)4.15868829
38complement activation (GO:0006956)4.13999828
39regulation of guanylate cyclase activity (GO:0031282)4.13840419
40regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.11981228
41positive regulation of antigen processing and presentation (GO:0002579)4.04951392
42mast cell degranulation (GO:0043303)3.98693657
43mast cell activation involved in immune response (GO:0002279)3.98693657
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91384126
45regulation of megakaryocyte differentiation (GO:0045652)3.89500657
46positive regulation of pseudopodium assembly (GO:0031274)3.88147956
47NADH metabolic process (GO:0006734)3.87118493
48regulation of chemokine secretion (GO:0090196)3.86262823
49antigen processing and presentation of endogenous antigen (GO:0019883)3.86256719
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84990076
51positive regulation of exocytosis (GO:0045921)3.79479616
52bone remodeling (GO:0046849)3.78685483
53regulation of respiratory burst (GO:0060263)3.73388479
54mammary gland alveolus development (GO:0060749)3.71637785
55immunoglobulin mediated immune response (GO:0016064)3.71482333
56peptide catabolic process (GO:0043171)3.67416212
57indolalkylamine metabolic process (GO:0006586)3.64724939
58regulation of antigen processing and presentation (GO:0002577)3.59342696
59lipoxygenase pathway (GO:0019372)3.57964983
60cytokine production involved in immune response (GO:0002367)3.56515245
61positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.54541750
62unsaturated fatty acid biosynthetic process (GO:0006636)3.51236249
63regulation of pseudopodium assembly (GO:0031272)3.48986345
64virion attachment to host cell (GO:0019062)3.36888882
65adhesion of symbiont to host cell (GO:0044650)3.36888882
66actin nucleation (GO:0045010)3.36874251
67eosinophil migration (GO:0072677)3.36589237
68detection of bacterium (GO:0016045)3.35507406
69mast cell activation (GO:0045576)3.33020694
70eosinophil chemotaxis (GO:0048245)3.31807212
71negative regulation of erythrocyte differentiation (GO:0045647)3.28259215
72regulation of vitamin metabolic process (GO:0030656)3.26693534
73fat-soluble vitamin biosynthetic process (GO:0042362)3.21797547
74regulation of B cell mediated immunity (GO:0002712)3.18580481
75detection of other organism (GO:0098543)3.17987397
76activation of JUN kinase activity (GO:0007257)3.17107507
77positive regulation of guanylate cyclase activity (GO:0031284)3.15332405
78definitive hemopoiesis (GO:0060216)3.14520194
79glycosphingolipid catabolic process (GO:0046479)3.10940336
80cellular biogenic amine biosynthetic process (GO:0042401)3.05592143
81amine biosynthetic process (GO:0009309)3.05592143
82protein activation cascade (GO:0072376)3.05347605
83regulation of immunoglobulin mediated immune response (GO:0002889)3.05054275
84intestinal absorption (GO:0050892)3.04795295
85negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.03985239
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02236076
87glycolipid catabolic process (GO:0019377)3.01273800
88cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.96350972
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95390156
90regulation of calcium-mediated signaling (GO:0050848)2.92198751
91heparin metabolic process (GO:0030202)2.91536487
92heparin biosynthetic process (GO:0030210)2.91536487
93fructose metabolic process (GO:0006000)2.91199749
94humoral immune response (GO:0006959)2.90868982
95positive regulation of gamma-delta T cell activation (GO:0046645)2.88939146
96germ cell migration (GO:0008354)2.84366866
97cellular response to glucose stimulus (GO:0071333)2.83894715
98positive regulation of macrophage differentiation (GO:0045651)2.82699782
99interferon-gamma-mediated signaling pathway (GO:0060333)2.82604481
100response to nitric oxide (GO:0071731)2.80845452
101diacylglycerol metabolic process (GO:0046339)2.79737182
102hormone catabolic process (GO:0042447)2.79025096
103phosphatidylserine acyl-chain remodeling (GO:0036150)2.78667580
104adhesion of symbiont to host (GO:0044406)2.77794051
105transcytosis (GO:0045056)2.76897040
106positive regulation of lipoprotein lipase activity (GO:0051006)2.74644142
107positive regulation of triglyceride lipase activity (GO:0061365)2.74644142
108regulation of cGMP biosynthetic process (GO:0030826)2.74636620
109NIK/NF-kappaB signaling (GO:0038061)2.72744274
110megakaryocyte development (GO:0035855)2.70846709
111positive regulation of glycoprotein biosynthetic process (GO:0010560)2.70542834
112phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70185888
113urea cycle (GO:0000050)2.68750791
114regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66280789
115regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66280789
116endocrine process (GO:0050886)2.66280789
117cellular response to hexose stimulus (GO:0071331)2.65920338
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.65886877
119cellular response to nitric oxide (GO:0071732)2.65430565
120cellular response to reactive nitrogen species (GO:1902170)2.63426369
121surfactant homeostasis (GO:0043129)2.63175107
122regulation of macrophage differentiation (GO:0045649)2.62986089
123neutrophil activation involved in immune response (GO:0002283)2.62877762
124cyclooxygenase pathway (GO:0019371)2.60831868
125low-density lipoprotein particle remodeling (GO:0034374)2.60512693
126regulation of acute inflammatory response (GO:0002673)2.60507782
127defense response to fungus (GO:0050832)2.59626781
128ethanol oxidation (GO:0006069)2.58860560
129cellular response to monosaccharide stimulus (GO:0071326)2.58399421
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56779316
131B cell mediated immunity (GO:0019724)2.54665398
132midbrain development (GO:0030901)2.52932143
133negative regulation of meiosis (GO:0045835)2.52842189
134keratinization (GO:0031424)2.52695173
135ceramide catabolic process (GO:0046514)2.52431654
136regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.52372759
137epoxygenase P450 pathway (GO:0019373)2.51460017
138positive regulation of granulocyte chemotaxis (GO:0071624)2.50788326
139lipoprotein transport (GO:0042953)2.50694622
140positive regulation of glycoprotein metabolic process (GO:1903020)2.47417722
141urea metabolic process (GO:0019627)2.46877404
142indole-containing compound metabolic process (GO:0042430)2.46220353
143regulation of gamma-delta T cell differentiation (GO:0045586)2.46042041
144positive regulation of fatty acid biosynthetic process (GO:0045723)2.43930062
145mannose metabolic process (GO:0006013)2.43670252
146negative regulation of granulocyte differentiation (GO:0030853)2.41759242
147mature B cell differentiation involved in immune response (GO:0002313)2.41051995
148positive regulation of B cell differentiation (GO:0045579)2.40404306
149cellular response to thyroid hormone stimulus (GO:0097067)2.39356167
150regulation of gamma-delta T cell activation (GO:0046643)2.39353193
151dendritic cell chemotaxis (GO:0002407)2.39188768
152production of molecular mediator of immune response (GO:0002440)2.38926692
153positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.38893817
154regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.38893817
155T-helper 1 type immune response (GO:0042088)2.38263020
156cellular response to zinc ion (GO:0071294)2.38046940
157negative regulation of leukocyte migration (GO:0002686)2.37056756
158nitrogen cycle metabolic process (GO:0071941)2.36408380
159phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.35991590
160negative regulation of macrophage differentiation (GO:0045650)2.35879761
161adenosine receptor signaling pathway (GO:0001973)2.35415521
162regulation of T cell migration (GO:2000404)2.35220058
163cellular response to cadmium ion (GO:0071276)2.35092794
164regulation of necrotic cell death (GO:0010939)2.34596999
165positive regulation of systemic arterial blood pressure (GO:0003084)2.33786392
166cellular response to exogenous dsRNA (GO:0071360)2.33147798
167aromatic amino acid family metabolic process (GO:0009072)2.32376313
168actin filament capping (GO:0051693)2.31387431
169lung lobe morphogenesis (GO:0060463)2.28882901
170relaxation of smooth muscle (GO:0044557)2.28313546
171positive regulation of leukocyte mediated immunity (GO:0002705)2.26863402
172cellular response to carbohydrate stimulus (GO:0071322)2.22593746
173regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.19499146
174positive regulation of astrocyte differentiation (GO:0048711)2.19211179
175positive regulation of macrophage activation (GO:0043032)2.15704059
176response to corticosterone (GO:0051412)2.11188752
177histamine secretion (GO:0001821)2.08621732
178lysosome localization (GO:0032418)2.08604699
179fatty acid derivative metabolic process (GO:1901568)2.08020390
180icosanoid metabolic process (GO:0006690)2.08020390
181cellular glucose homeostasis (GO:0001678)2.06219115
182negative regulation of complement activation (GO:0045916)2.02837691
183negative regulation of bone resorption (GO:0045779)2.02146198
184mating behavior (GO:0007617)2.01622978
185positive regulation of erythrocyte differentiation (GO:0045648)2.00497337
186angiotensin maturation (GO:0002003)17.8492639
187positive regulation of mast cell activation involved in immune response (GO:0033008)17.7183927
188positive regulation of mast cell degranulation (GO:0043306)17.7183927
189regulation of hypersensitivity (GO:0002883)16.0491291
190positive regulation of mast cell activation (GO:0033005)14.7266015
191positive regulation of myeloid leukocyte mediated immunity (GO:0002888)14.4566421
192positive regulation of leukocyte degranulation (GO:0043302)13.2547416
193positive regulation of inflammatory response to antigenic stimulus (GO:0002863)11.4537303
194positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)11.0195484
195regulation of acute inflammatory response to antigenic stimulus (GO:0002864)11.0109329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.76315237
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.60829100
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.52201139
4EGR1_19032775_ChIP-ChIP_M12_Human3.41235870
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.61035054
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53321733
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51580510
8GATA1_19941827_ChIP-Seq_MEL_Mouse2.44473832
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43344457
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.33651451
11TCF7_22412390_ChIP-Seq_EML_Mouse2.21272197
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.18578838
13RUNX1_22412390_ChIP-Seq_EML_Mouse2.13027384
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03647232
15BP1_19119308_ChIP-ChIP_Hs578T_Human13.3322681
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.99954477
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99609998
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.96334502
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.90295069
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.88526372
21E2F7_22180533_ChIP-Seq_HELA_Human1.79454592
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76539809
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76471298
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74583010
25GATA1_19941826_ChIP-Seq_K562_Human1.74255243
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74213434
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.70076910
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69133954
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68865171
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68745617
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68555272
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.66510282
33GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.66019223
34VDR_21846776_ChIP-Seq_THP-1_Human1.65663093
35KDM2B_26808549_Chip-Seq_DND41_Human1.62546370
36CLOCK_20551151_ChIP-Seq_293T_Human1.58802518
37BCOR_27268052_Chip-Seq_Bcells_Human1.58186668
38GATA1_22025678_ChIP-Seq_K562_Human1.56789641
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53959808
40MAF_26560356_Chip-Seq_TH1_Human1.52304714
41BCL6_27268052_Chip-Seq_Bcells_Human1.51202496
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50963224
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46911119
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45021870
45VDR_24787735_ChIP-Seq_THP-1_Human1.44771750
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44459897
47VDR_24763502_ChIP-Seq_THP-1_Human1.44306569
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44295997
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.43709318
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41728910
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41476881
52LXR_22292898_ChIP-Seq_THP-1_Human1.39906743
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39711136
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35139292
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34421585
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32949076
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32376458
58SPI1_23127762_ChIP-Seq_K562_Human1.31919271
59RUNX_20019798_ChIP-Seq_JUKART_Human1.30360952
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.29519282
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29148340
62GATA4_25053715_ChIP-Seq_YYC3_Human1.28704391
63TP53_16413492_ChIP-PET_HCT116_Human1.24443206
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23981832
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22640304
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.21295055
67SA1_27219007_Chip-Seq_Bcells_Human1.21014314
68RACK7_27058665_Chip-Seq_MCF-7_Human1.20549981
69GATA2_19941826_ChIP-Seq_K562_Human1.18899830
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17943319
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17812550
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17703542
73SOX2_20726797_ChIP-Seq_SW620_Human1.17544981
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16822134
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16546345
76MYC_22102868_ChIP-Seq_BL_Human1.16503820
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15931242
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15883679
79STAT1_20625510_ChIP-Seq_HELA_Human1.15779697
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14457555
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13742481
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.13708242
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13129444
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12611184
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11777514
86P68_20966046_ChIP-Seq_HELA_Human1.09484201
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07535652
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.07023081
89UTX_26944678_Chip-Seq_JUKART_Human1.06549409
90ZNF263_19887448_ChIP-Seq_K562_Human1.05856991
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05738566
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05580551
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05188319
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05088077
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03980232
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.03779770
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03717087
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.03565888
99KDM2B_26808549_Chip-Seq_K562_Human1.03325236
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01775391
101MYB_26560356_Chip-Seq_TH1_Human1.01766113
102GATA6_25053715_ChIP-Seq_YYC3_Human1.01691586
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01643453
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.01455543
105DROSHA_22980978_ChIP-Seq_HELA_Human0.99912964
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99334612
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98847436
108P300_27268052_Chip-Seq_Bcells_Human0.98049388
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97852657
110* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97644504
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97505867
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.96661564
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94884088
114* CTCF_20526341_ChIP-Seq_ESCs_Human0.94632295
115MYB_26560356_Chip-Seq_TH2_Human0.93610445
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93568042
117NCOR1_26117541_ChIP-Seq_K562_Human0.92345078
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90879497
119GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89668689
120* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89338346
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88844117
122SPI1_23547873_ChIP-Seq_NB4_Human0.88582816
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88087865
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86603186
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86603186
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86603186
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86437965
128SPI1_20517297_ChIP-Seq_HL60_Human0.85042647
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85019129
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84605404
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84553923
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84115950
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83728135
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83277423
135SMC4_20622854_ChIP-Seq_HELA_Human0.82110836
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82108830
137STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82000891
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81241856
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81053795
140* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80607772
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80078307
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76976501
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76738833
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.76323915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.87928830
2MP0000465_gastrointestinal_hemorrhage4.74392285
3MP0008775_abnormal_heart_ventricle4.05448263
4MP0002148_abnormal_hypersensitivity_rea4.01311897
5MP0003638_abnormal_response/metabolism_3.62562691
6MP0004808_abnormal_hematopoietic_stem3.27574979
7MP0005464_abnormal_platelet_physiology3.23488088
8MP0003436_decreased_susceptibility_to3.14820072
9MP0009379_abnormal_foot_pigmentation3.08413858
10MP0003724_increased_susceptibility_to3.00783088
11MP0003566_abnormal_cell_adhesion2.95908734
12MP0010155_abnormal_intestine_physiology2.86973056
13MP0009765_abnormal_xenobiotic_induced2.85686272
14MP0001835_abnormal_antigen_presentation2.59228434
15MP0003300_gastrointestinal_ulcer2.54241737
16MP0004147_increased_porphyrin_level2.43170251
17MP0010234_abnormal_vibrissa_follicle2.41512535
18MP0004782_abnormal_surfactant_physiolog2.34563799
19MP0005058_abnormal_lysosome_morphology2.25931694
20MP0003303_peritoneal_inflammation2.20221460
21MP0002419_abnormal_innate_immunity2.19714791
22MP0010329_abnormal_lipoprotein_level2.14405996
23MP0009785_altered_susceptibility_to2.05648335
24MP0005387_immune_system_phenotype2.00960406
25MP0001790_abnormal_immune_system2.00960406
26MP0002398_abnormal_bone_marrow2.00301652
27MP0001800_abnormal_humoral_immune1.99408484
28MP0005367_renal/urinary_system_phenotyp1.93546632
29MP0000516_abnormal_urinary_system1.93546632
30MP0001666_abnormal_nutrient_absorption1.90951952
31MP0005000_abnormal_immune_tolerance1.89290808
32MP0000249_abnormal_blood_vessel1.88980955
33MP0002796_impaired_skin_barrier1.87129394
34MP0005646_abnormal_pituitary_gland1.85500612
35* MP0002420_abnormal_adaptive_immunity1.82948753
36* MP0001819_abnormal_immune_cell1.82222661
37MP0000685_abnormal_immune_system1.80911296
38MP0004885_abnormal_endolymph1.80485645
39MP0008873_increased_physiological_sensi1.74558063
40MP0001873_stomach_inflammation1.74545181
41MP0006082_CNS_inflammation1.72790016
42MP0005409_darkened_coat_color1.67650561
43MP0004019_abnormal_vitamin_homeostasis1.67585900
44MP0004858_abnormal_nervous_system1.65952450
45MP0002723_abnormal_immune_serum1.61145355
46MP0002909_abnormal_adrenal_gland1.59714339
47MP0001533_abnormal_skeleton_physiology1.52392446
48MP0001970_abnormal_pain_threshold1.52223853
49MP0005671_abnormal_response_to1.49497864
50MP0001663_abnormal_digestive_system1.47940583
51MP0003183_abnormal_peptide_metabolism1.46472969
52MP0002733_abnormal_thermal_nociception1.45723810
53MP0005365_abnormal_bile_salt1.42069291
54MP0002452_abnormal_antigen_presenting1.41355029
55MP0005085_abnormal_gallbladder_physiolo1.41342150
56MP0003329_amyloid_beta_deposits1.40779083
57MP0005623_abnormal_meninges_morphology1.40709556
58MP0002722_abnormal_immune_system1.39345536
59MP0005174_abnormal_tail_pigmentation1.38384434
60* MP0005025_abnormal_response_to1.35576503
61MP0004264_abnormal_extraembryonic_tissu1.35022127
62MP0002166_altered_tumor_susceptibility1.34887497
63MP0008770_decreased_survivor_rate1.33405053
64MP0004924_abnormal_behavior1.30720635
65MP0005386_behavior/neurological_phenoty1.30720635
66MP0008469_abnormal_protein_level1.29892593
67MP0009763_increased_sensitivity_to1.28136377
68MP0002405_respiratory_system_inflammati1.26630154
69MP0000716_abnormal_immune_system1.26142967
70MP0003866_abnormal_defecation1.24722167
71MP0005275_abnormal_skin_tensile1.23606942
72MP0002254_reproductive_system_inflammat1.22708414
73MP0004510_myositis1.21806223
74MP0002138_abnormal_hepatobiliary_system1.21223131
75MP0000343_altered_response_to1.19833147
76MP0009840_abnormal_foam_cell1.19312821
77MP0009643_abnormal_urine_homeostasis1.19268685
78MP0002429_abnormal_blood_cell1.18404903
79MP0004859_abnormal_synaptic_plasticity1.18010481
80MP0008004_abnormal_stomach_pH1.17646905
81MP0002998_abnormal_bone_remodeling1.17591167
82MP0001664_abnormal_digestion1.15955719
83MP0010307_abnormal_tumor_latency1.14911727
84MP0010352_gastrointestinal_tract_polyps1.12542046
85MP0000490_abnormal_crypts_of1.12126233
86MP0001958_emphysema1.11945255
87MP0005381_digestive/alimentary_phenotyp1.08634214
88MP0001188_hyperpigmentation1.08593491
89MP0003705_abnormal_hypodermis_morpholog1.05874280
90MP0005670_abnormal_white_adipose1.05632880
91MP0001764_abnormal_homeostasis1.05307520
92MP0005666_abnormal_adipose_tissue1.05198650
93MP0004085_abnormal_heartbeat1.04946585
94MP0008874_decreased_physiological_sensi1.00720814
95MP0001845_abnormal_inflammatory_respons0.99293488
96MP0005535_abnormal_body_temperature0.98885383
97MP0000604_amyloidosis0.97301100
98MP0002876_abnormal_thyroid_physiology0.96787807
99MP0005167_abnormal_blood-brain_barrier0.96776830
100MP0003453_abnormal_keratinocyte_physiol0.96737304
101MP0002933_joint_inflammation0.95811429
102MP0005075_abnormal_melanosome_morpholog0.95511835
103MP0003448_altered_tumor_morphology0.95410262
104MP0001765_abnormal_ion_homeostasis0.94404558
105MP0005390_skeleton_phenotype0.93203379
106MP0002971_abnormal_brown_adipose0.93172652
107MP0005165_increased_susceptibility_to0.93021052
108MP0000462_abnormal_digestive_system0.92773417
109MP0000477_abnormal_intestine_morphology0.92730528
110MP0004883_abnormal_blood_vessel0.92197613
111MP0003828_pulmonary_edema0.91489546
112MP0002396_abnormal_hematopoietic_system0.90940601
113MP0002139_abnormal_hepatobiliary_system0.90486015
114MP0004947_skin_inflammation0.90306948
115MP0000703_abnormal_thymus_morphology0.90171399
116MP0002118_abnormal_lipid_homeostasis0.89724425
117MP0009780_abnormal_chondrocyte_physiolo0.88727868
118MP0001851_eye_inflammation0.88276239
119MP0001727_abnormal_embryo_implantation0.88161960
120MP0000689_abnormal_spleen_morphology0.87986621
121MP0009115_abnormal_fat_cell0.86970177
122MP0001501_abnormal_sleep_pattern0.86785924
123MP0005360_urolithiasis0.85186217
124MP0001853_heart_inflammation0.84887038
125MP0003191_abnormal_cellular_cholesterol0.84641375
126MP0003763_abnormal_thymus_physiology0.84630053
127MP0005334_abnormal_fat_pad0.84524691
128MP0002972_abnormal_cardiac_muscle0.83609494
129MP0005332_abnormal_amino_acid0.83140662
130MP0005501_abnormal_skin_physiology0.82934350
131MP0009333_abnormal_splenocyte_physiolog0.82833369
132MP0005584_abnormal_enzyme/coenzyme_acti0.81037598
133MP0002136_abnormal_kidney_physiology0.80926352
134MP0009384_cardiac_valve_regurgitation0.79295407
135MP0005166_decreased_susceptibility_to0.78946221
136MP0004185_abnormal_adipocyte_glucose0.77890010
137MP0002128_abnormal_blood_circulation0.74912947
138MP0003806_abnormal_nucleotide_metabolis0.69736545
139MP0001849_ear_inflammation0.69163105
140MP0001545_abnormal_hematopoietic_system0.68569210
141MP0005397_hematopoietic_system_phenotyp0.68569210
142MP0003172_abnormal_lysosome_physiology0.68532436
143MP0009278_abnormal_bone_marrow0.63671062
144MP0008961_abnormal_basal_metabolism0.62832109
145MP0005310_abnormal_salivary_gland0.62796622
146MP0003795_abnormal_bone_structure0.61949133
147MP0005620_abnormal_muscle_contractility0.61455386
148MP0003075_altered_response_to0.61273322
149MP0008872_abnormal_physiological_respon0.60596455
150MP0009931_abnormal_skin_appearance0.59748332
151MP0003656_abnormal_erythrocyte_physiolo0.59461826
152MP0009764_decreased_sensitivity_to0.59068399

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.63416673
2Abnormal platelet volume (HP:0011876)9.26785692
3Purpura (HP:0000979)9.06272923
4Menorrhagia (HP:0000132)8.87281099
5Prolonged bleeding time (HP:0003010)8.71376504
6Impaired platelet aggregation (HP:0003540)7.97213835
7Abnormal platelet function (HP:0011869)7.97213835
8Gingival bleeding (HP:0000225)7.55631625
9Systemic lupus erythematosus (HP:0002725)6.26577811
10Malnutrition (HP:0004395)5.05954378
11Papilledema (HP:0001085)4.64921181
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.62137852
13Epistaxis (HP:0000421)4.49715633
14Increased IgE level (HP:0003212)4.33645672
15Aplastic anemia (HP:0001915)4.27211666
16Eczematoid dermatitis (HP:0000976)4.17908319
17Abnormality of complement system (HP:0005339)3.90334470
18Complement deficiency (HP:0004431)3.86477722
19Glomerulonephritis (HP:0000099)3.66854074
20Interstitial pulmonary disease (HP:0006530)3.37152542
21Decreased circulating renin level (HP:0003351)3.27033577
22Chronic diarrhea (HP:0002028)3.25986647
23Bruising susceptibility (HP:0000978)3.23379484
24Cellulitis (HP:0100658)3.21555460
25Abnormality of macrophages (HP:0004311)3.15511885
26Abnormal sex determination (HP:0012244)3.10306820
27Sex reversal (HP:0012245)3.10306820
28Elevated erythrocyte sedimentation rate (HP:0003565)3.10191629
29Abnormality of proline metabolism (HP:0010907)3.07270563
30Hydroxyprolinuria (HP:0003080)3.07270563
31Neoplasm of head and neck (HP:0012288)3.01539458
32Esophageal neoplasm (HP:0100751)3.01539458
33Abnormality of glycolipid metabolism (HP:0010969)2.96090826
34Abnormality of liposaccharide metabolism (HP:0010968)2.96090826
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.96090826
36Abnormality of binocular vision (HP:0011514)2.92403110
37Diplopia (HP:0000651)2.92403110
38Chronic otitis media (HP:0000389)2.79353009
39Poikilocytosis (HP:0004447)2.79056045
40Myositis (HP:0100614)2.78389634
41Dysostosis multiplex (HP:0000943)2.77443961
42White forelock (HP:0002211)2.71168370
43Autoimmune thrombocytopenia (HP:0001973)2.68146790
44Cerebral palsy (HP:0100021)2.66043047
45Nephritis (HP:0000123)2.64309149
46Vacuolated lymphocytes (HP:0001922)2.63705726
47Recurrent bacterial skin infections (HP:0005406)2.61184218
48Insomnia (HP:0100785)2.60497681
49Nausea (HP:0002018)2.60194308
50Agammaglobulinemia (HP:0004432)2.56697036
51Abnormality of the nasal mucosa (HP:0000433)2.55800941
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.54559951
53Hypergammaglobulinemia (HP:0010702)2.54482499
54Ileus (HP:0002595)2.52237614
55Cerebral aneurysm (HP:0004944)2.50652118
56Gingivitis (HP:0000230)2.49284624
57Obstructive lung disease (HP:0006536)2.46644278
58Chronic obstructive pulmonary disease (HP:0006510)2.46644278
59Neoplasm of the peripheral nervous system (HP:0100007)2.46053498
60Slender build (HP:0001533)2.42533243
61Amyloidosis (HP:0011034)2.39045670
62Supranuclear gaze palsy (HP:0000605)2.38965243
63Recurrent viral infections (HP:0004429)2.38494044
64Pustule (HP:0200039)2.37216742
65Neurofibrillary tangles (HP:0002185)2.37013810
66Gastrointestinal stroma tumor (HP:0100723)2.33653721
67Cerebral inclusion bodies (HP:0100314)2.33064759
68Recurrent gram-negative bacterial infections (HP:0005420)2.32105473
69Vasculitis (HP:0002633)2.31977956
70Patchy hypopigmentation of hair (HP:0011365)2.30963327
71Recurrent abscess formation (HP:0002722)2.29211374
72Abnormality of small intestinal villus morphology (HP:0011472)2.28655009
73Villous atrophy (HP:0011473)2.28655009
74Growth hormone excess (HP:0000845)2.28195476
75Orchitis (HP:0100796)2.27122122
76Meningitis (HP:0001287)2.24864061
77Skin rash (HP:0000988)2.23659571
78Hemoptysis (HP:0002105)2.18999199
79Widely patent fontanelles and sutures (HP:0004492)2.18001694
80Alopecia of scalp (HP:0002293)2.17514053
81Abnormality of renin-angiotensin system (HP:0000847)2.16193314
82Hemorrhage of the eye (HP:0011885)2.15228078
83Hyperactive renin-angiotensin system (HP:0000841)2.12071024
84Bone cyst (HP:0012062)2.11581947
85Mediastinal lymphadenopathy (HP:0100721)2.09877219
86Erythema (HP:0010783)2.09245247
87Polygenic inheritance (HP:0010982)2.09218025
88Hyperacusis (HP:0010780)2.08156538
89Alkalosis (HP:0001948)2.07673163
90Pulmonary infiltrates (HP:0002113)2.07502481
91Abnormality of oral frenula (HP:0000190)2.06864649
92Osteomyelitis (HP:0002754)2.06178589
93Palmoplantar hyperkeratosis (HP:0000972)2.05545673
94Recurrent cutaneous fungal infections (HP:0011370)2.03623946
95Chronic mucocutaneous candidiasis (HP:0002728)2.03623946
96Encephalitis (HP:0002383)2.01688979
97Petechiae (HP:0000967)11.9928550
98Heterochromia iridis (HP:0001100)1.95532843
99Thin bony cortex (HP:0002753)1.95486574
100Metabolic alkalosis (HP:0200114)1.94892392
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94803109
102Premature loss of primary teeth (HP:0006323)1.93866698
103Emphysema (HP:0002097)1.93551792
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.93181973
105Hypophosphatemia (HP:0002148)1.92867525
106Abnormality of T cell physiology (HP:0011840)1.92143924
107Segmental peripheral demyelination/remyelination (HP:0003481)1.91471176
108Congenital sensorineural hearing impairment (HP:0008527)1.90824790
109Axonal loss (HP:0003447)1.90709514
110Panhypogammaglobulinemia (HP:0003139)1.90672316
111Urticaria (HP:0001025)1.89411584
112Abnormality of B cell number (HP:0010975)1.89169407
113Germ cell neoplasia (HP:0100728)1.88190891
114Hematochezia (HP:0002573)1.88098541
115Deep venous thrombosis (HP:0002625)1.87670620
116Apathy (HP:0000741)1.85678000
117Mucopolysacchariduria (HP:0008155)1.81048930
118Urinary glycosaminoglycan excretion (HP:0003541)1.81048930
119Acute myeloid leukemia (HP:0004808)1.79693770
120Recurrent fungal infections (HP:0002841)1.76725513
121Ankyloglossia (HP:0010296)1.70799038
122Diminished motivation (HP:0000745)1.68701309
123Disproportionate tall stature (HP:0001519)1.66698938
124Shallow orbits (HP:0000586)1.64577501
125Renal salt wasting (HP:0000127)1.63777819
126Xanthomatosis (HP:0000991)1.62730145
127IgM deficiency (HP:0002850)1.55705270
128Leukocytosis (HP:0001974)1.55096393
129Inflammation of the large intestine (HP:0002037)1.53806981
130Increased density of long bones (HP:0006392)1.53798077
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53760373
132Abnormality of polysaccharide metabolism (HP:0011012)1.53760373
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53760373
134Abnormality of the Achilles tendon (HP:0005109)1.52720565
135Joint hemorrhage (HP:0005261)1.51678516
136Fibroma (HP:0010614)1.50661344
137Spontaneous hematomas (HP:0007420)1.49580250
138Achilles tendon contracture (HP:0001771)1.48814798
139Polycythemia (HP:0001901)1.48733001
140Striae distensae (HP:0001065)1.48337508
141Hyperaldosteronism (HP:0000859)1.47777206
142Global brain atrophy (HP:0002283)1.46691197
143Gastrointestinal inflammation (HP:0004386)1.46365937
144Aortic aneurysm (HP:0004942)1.44834052
145Fibrous tissue neoplasm (HP:0012316)1.42139056
146Gonadal dysgenesis (HP:0000133)1.41603977
147Recurrent skin infections (HP:0001581)1.41094915
148Increased cerebral lipofuscin (HP:0011813)1.38560109
149Colitis (HP:0002583)1.38377476
150Hemiplegia (HP:0002301)1.38060907
151Acrocyanosis (HP:0001063)1.37023558
152Adrenal overactivity (HP:0002717)1.36987464
153Increased neuronal autofluorescent lipopigment (HP:0002074)1.36809497
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.36625435
155Overriding aorta (HP:0002623)1.35788399
156Large hands (HP:0001176)1.33870555
157Bronchomalacia (HP:0002780)1.33575008
158Nasal polyposis (HP:0100582)1.33404027
159Severe short stature (HP:0003510)1.33336224
160Cervical subluxation (HP:0003308)1.32327967
161Neoplasm of the rectum (HP:0100743)1.32221297
162Sudden cardiac death (HP:0001645)1.31590356
163Thoracolumbar scoliosis (HP:0002944)1.30739190
164Myocardial infarction (HP:0001658)1.29891798
165Abnormality of the lower motor neuron (HP:0002366)1.29813768
166Arterial tortuosity (HP:0005116)1.29410335
167Elfin facies (HP:0004428)1.29333622
168Renovascular hypertension (HP:0100817)1.27772534
169Increased connective tissue (HP:0009025)1.26412924
170Hypercortisolism (HP:0001578)1.26197723
171Lymphedema (HP:0001004)1.25557819
172Mitral stenosis (HP:0001718)1.24999012
173Mitral valve prolapse (HP:0001634)1.24314582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT6.87650170
2MATK4.26602088
3RIPK43.52825567
4EEF2K3.45184198
5FES3.20506366
6MAP4K13.07437339
7ACVR1B2.96736604
8TRIB32.64246208
9CDK62.49162948
10NTRK22.40684314
11TXK2.38705574
12BLK2.17428482
13FLT31.97982560
14PRPF4B1.90119467
15GRK61.80481517
16TGFBR21.73211738
17TYK21.72002328
18PIM21.71980796
19MAPKAPK51.69392172
20FGFR21.66924532
21CSF1R1.66780220
22EPHA31.66343986
23ZAP701.62533881
24SYK1.62014931
25MAPK151.53773475
26PKN21.51799133
27MAP3K141.47034408
28MAPKAPK31.46519696
29SIK21.46145531
30FGFR41.43698331
31PTK61.42459468
32MAP3K11.41112944
33IKBKE1.38978801
34BMX1.37993515
35MST1R1.34988382
36EPHB21.34681019
37ITK1.34643264
38CSNK1G31.30726283
39IKBKB1.29929724
40PRKG21.28242394
41JAK21.25600483
42MAPKAPK21.24839502
43SIK11.24064616
44CAMK1G1.22948113
45PRKACG1.22239196
46NEK91.18115795
47CDC42BPA1.14317841
48LYN1.14191150
49KDR1.10815914
50TYRO31.10113332
51CAMK1D1.09337510
52MYLK1.09044438
53ABL21.07675168
54TAOK31.03724193
55MAP2K31.02167027
56DDR21.00042596
57CSNK1G20.99491074
58CAMKK20.99056320
59LRRK20.98667240
60MAP3K130.98311410
61TESK20.94621923
62PDPK10.94370989
63TRPM70.92415535
64ALK0.92149386
65PRKACB0.92070412
66CAMKK10.89176771
67MAP3K30.89139756
68HIPK20.88920893
69RPS6KB20.81862238
70IRAK10.80372988
71CSNK1G10.76702881
72BTK0.75649026
73STK100.73450495
74PDGFRA0.73440139
75MAP2K60.73365281
76IRAK30.72802081
77FER0.72616016
78BMPR20.70753420
79RPS6KL10.70692587
80RPS6KC10.70692587
81SCYL20.69865747
82HCK0.69404469
83NME10.66058060
84PAK20.65835769
85GRK70.64191257
86PDK10.62822153
87RPS6KA60.62521539
88PIK3CA0.61179732
89IRAK40.60613457
90EPHA20.60569841
91MAPK70.60428700
92TESK10.60220660
93TEC0.59472624
94RPS6KA20.59344845
95MAP2K10.58489652
96MAP3K70.58325411
97MAP3K110.58259350
98TAOK20.57560367
99NLK0.56654119
100FGFR30.56529392
101PIK3CG0.55746770
102NME20.55298790
103JAK10.55293011
104TGFBR10.55252315
105LCK0.54281174
106SRC0.53868664
107PRKAA20.53371951
108TIE10.53052824
109UHMK10.52898694
110DYRK1B0.52788547
111PRKCQ0.51306973
112RET0.50445310
113ERN10.50234550
114EPHB10.48481844
115MAP3K100.47388619
116PIM10.46663242
117STK240.46275240
118MAPK120.45823412
119TTN0.45744031
120PDGFRB0.45438898
121FGR0.45419629
122RIPK10.44283781
123FYN0.41911837
124MAPK30.41415444
125DMPK0.40392888
126TBK10.37603161
127MAPK110.36876561
128RPS6KA30.36385974
129MAP3K60.36236203
130PRKCB0.35994307
131MAP3K20.35497224
132KSR20.34649772
133DAPK30.33865350
134CDK40.33330176
135PRKACA0.31791070
136PTK20.31444832
137MAPK40.31147684
138TNK20.31078539
139MAP2K20.30649763
140JAK30.28322280
141ILK0.26614485
142TAOK10.26557391
143CAMK2A0.26315684
144MAPK10.24433631
145CDK50.24357034
146CSK0.23459088
147DAPK20.20878479

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.28781833
2Staphylococcus aureus infection_Homo sapiens_hsa051503.02257941
3Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.99418276
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.76461782
5Allograft rejection_Homo sapiens_hsa053302.75734181
6Fat digestion and absorption_Homo sapiens_hsa049752.68512573
7Autoimmune thyroid disease_Homo sapiens_hsa053202.50342357
8Graft-versus-host disease_Homo sapiens_hsa053322.35338401
9Vitamin digestion and absorption_Homo sapiens_hsa049772.31651108
10Other glycan degradation_Homo sapiens_hsa005112.24684810
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17614499
12Tryptophan metabolism_Homo sapiens_hsa003802.08046025
13Renin-angiotensin system_Homo sapiens_hsa0461410.3501905
14Asthma_Homo sapiens_hsa0531010.0175472
15Type I diabetes mellitus_Homo sapiens_hsa049401.91933041
16Mineral absorption_Homo sapiens_hsa049781.90585573
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90029451
18Linoleic acid metabolism_Homo sapiens_hsa005911.75772206
19Pertussis_Homo sapiens_hsa051331.58483792
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56569081
21Antigen processing and presentation_Homo sapiens_hsa046121.53809238
22Rheumatoid arthritis_Homo sapiens_hsa053231.45402554
23Fructose and mannose metabolism_Homo sapiens_hsa000511.44233180
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.40994001
25Sphingolipid signaling pathway_Homo sapiens_hsa040711.39473689
26Hematopoietic cell lineage_Homo sapiens_hsa046401.38908815
27Nitrogen metabolism_Homo sapiens_hsa009101.38123965
28Serotonergic synapse_Homo sapiens_hsa047261.34816974
29PPAR signaling pathway_Homo sapiens_hsa033201.30783545
30Ovarian steroidogenesis_Homo sapiens_hsa049131.28763362
31Platelet activation_Homo sapiens_hsa046111.20179334
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17911219
33Ether lipid metabolism_Homo sapiens_hsa005651.15922230
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14978178
35Tuberculosis_Homo sapiens_hsa051521.14436817
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13886952
37Protein digestion and absorption_Homo sapiens_hsa049741.03768168
38Pancreatic secretion_Homo sapiens_hsa049721.03433679
39Cocaine addiction_Homo sapiens_hsa050301.02682036
40Chemical carcinogenesis_Homo sapiens_hsa052041.02488544
41Glycerolipid metabolism_Homo sapiens_hsa005610.97638687
42Lysosome_Homo sapiens_hsa041420.93742479
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87022554
44Primary immunodeficiency_Homo sapiens_hsa053400.86653613
45Malaria_Homo sapiens_hsa051440.86486026
46Fatty acid degradation_Homo sapiens_hsa000710.86452870
47Caffeine metabolism_Homo sapiens_hsa002320.84821451
48Phagosome_Homo sapiens_hsa041450.83046226
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.82833078
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.82759996
51Influenza A_Homo sapiens_hsa051640.81343910
52ECM-receptor interaction_Homo sapiens_hsa045120.81022417
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.78143107
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77963926
55Glutathione metabolism_Homo sapiens_hsa004800.76984432
56Retinol metabolism_Homo sapiens_hsa008300.75590154
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75295806
58Chemokine signaling pathway_Homo sapiens_hsa040620.74887399
59Starch and sucrose metabolism_Homo sapiens_hsa005000.73845224
60Amphetamine addiction_Homo sapiens_hsa050310.72281463
61B cell receptor signaling pathway_Homo sapiens_hsa046620.70356387
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69623316
63Toxoplasmosis_Homo sapiens_hsa051450.67652357
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67141078
65African trypanosomiasis_Homo sapiens_hsa051430.64470952
66Galactose metabolism_Homo sapiens_hsa000520.64130383
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63765304
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.60838021
69Prion diseases_Homo sapiens_hsa050200.60695865
70Salmonella infection_Homo sapiens_hsa051320.59196936
71Osteoclast differentiation_Homo sapiens_hsa043800.59041237
72Herpes simplex infection_Homo sapiens_hsa051680.57604027
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57467635
74Acute myeloid leukemia_Homo sapiens_hsa052210.57115039
75Sphingolipid metabolism_Homo sapiens_hsa006000.56554596
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54617014
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53647204
78Dilated cardiomyopathy_Homo sapiens_hsa054140.52891702
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.52778370
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52413679
81Hepatitis C_Homo sapiens_hsa051600.52279240
82Chronic myeloid leukemia_Homo sapiens_hsa052200.51576876
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50373067
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49891164
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47061624
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.44703190
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.44446188
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.44403574
89Sulfur metabolism_Homo sapiens_hsa009200.43300908
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42201595
91Histidine metabolism_Homo sapiens_hsa003400.41620491
92Complement and coagulation cascades_Homo sapiens_hsa046100.40414027
93Rap1 signaling pathway_Homo sapiens_hsa040150.40318712
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39282985
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39136023
96Arachidonic acid metabolism_Homo sapiens_hsa005900.36967124
97Long-term potentiation_Homo sapiens_hsa047200.35812226
98Legionellosis_Homo sapiens_hsa051340.35666509
99Glioma_Homo sapiens_hsa052140.34755302
100Small cell lung cancer_Homo sapiens_hsa052220.34476011
101Arginine and proline metabolism_Homo sapiens_hsa003300.34424900
102Phenylalanine metabolism_Homo sapiens_hsa003600.33947048
103Non-small cell lung cancer_Homo sapiens_hsa052230.33795818
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33673029
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32551414
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32372972
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32054126
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31155639
109Peroxisome_Homo sapiens_hsa041460.30848216
110Focal adhesion_Homo sapiens_hsa045100.29700382
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29618205
112Leishmaniasis_Homo sapiens_hsa051400.29378039
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28910412
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28307191
115Pentose phosphate pathway_Homo sapiens_hsa000300.27968207
116Amoebiasis_Homo sapiens_hsa051460.27583086
117Hepatitis B_Homo sapiens_hsa051610.27279020
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26170009
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25627974
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.25418439
121VEGF signaling pathway_Homo sapiens_hsa043700.24863106
122Estrogen signaling pathway_Homo sapiens_hsa049150.24465041
123Dopaminergic synapse_Homo sapiens_hsa047280.24325910
124Apoptosis_Homo sapiens_hsa042100.23447463
125Gastric acid secretion_Homo sapiens_hsa049710.21470917
126Viral myocarditis_Homo sapiens_hsa054160.20647932
127Cholinergic synapse_Homo sapiens_hsa047250.20402180
128Bile secretion_Homo sapiens_hsa049760.20016990
129TNF signaling pathway_Homo sapiens_hsa046680.19785274
130Colorectal cancer_Homo sapiens_hsa052100.19780975
131Circadian entrainment_Homo sapiens_hsa047130.19756955
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19541215
133Oxytocin signaling pathway_Homo sapiens_hsa049210.18689828
134Type II diabetes mellitus_Homo sapiens_hsa049300.18577417
135Renin secretion_Homo sapiens_hsa049240.18310726
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18205091
137Vibrio cholerae infection_Homo sapiens_hsa051100.18001355
138Thyroid hormone synthesis_Homo sapiens_hsa049180.17959422
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17813664
140Arginine biosynthesis_Homo sapiens_hsa002200.17487519
141p53 signaling pathway_Homo sapiens_hsa041150.17250368
142Gap junction_Homo sapiens_hsa045400.17026786
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.16951913
144Insulin resistance_Homo sapiens_hsa049310.16852212
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16796199
146Pancreatic cancer_Homo sapiens_hsa052120.16406461
147Calcium signaling pathway_Homo sapiens_hsa040200.16339574
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16158796
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.16113947
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15995530
151Proteoglycans in cancer_Homo sapiens_hsa052050.15795487
152Olfactory transduction_Homo sapiens_hsa047400.15532937
153cAMP signaling pathway_Homo sapiens_hsa040240.15040391
154Glucagon signaling pathway_Homo sapiens_hsa049220.14481565
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14469161
156GnRH signaling pathway_Homo sapiens_hsa049120.14407897
157Pathways in cancer_Homo sapiens_hsa052000.14086805
158Melanogenesis_Homo sapiens_hsa049160.13811582
159Viral carcinogenesis_Homo sapiens_hsa052030.13711322
160Morphine addiction_Homo sapiens_hsa050320.13616582
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13288514
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.12869305
163Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12333998
164Endocytosis_Homo sapiens_hsa041440.11416633
165Glutamatergic synapse_Homo sapiens_hsa047240.11270083

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