TPSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.55066674
2positive regulation of B cell differentiation (GO:0045579)5.16550764
3response to peptidoglycan (GO:0032494)4.95414157
4neutrophil activation involved in immune response (GO:0002283)4.95176023
5positive regulation of gamma-delta T cell activation (GO:0046645)4.77321331
6immunoglobulin mediated immune response (GO:0016064)4.60984024
7regulation of mast cell degranulation (GO:0043304)4.11923074
8pinocytosis (GO:0006907)4.03489656
9regulation of myeloid leukocyte mediated immunity (GO:0002886)3.99659875
10cellular response to exogenous dsRNA (GO:0071360)3.97286502
11regulation of leukocyte degranulation (GO:0043300)3.93681548
12response to muramyl dipeptide (GO:0032495)3.87560422
13negative regulation of interleukin-12 production (GO:0032695)3.85985271
14cellular response to thyroid hormone stimulus (GO:0097067)3.85787984
15macrophage differentiation (GO:0030225)3.81966551
16regulation of mast cell activation involved in immune response (GO:0033006)3.74175795
17negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.71260720
18negative regulation of nitric oxide biosynthetic process (GO:0045019)3.58701088
19regulation of B cell differentiation (GO:0045577)3.55570401
20mannose metabolic process (GO:0006013)3.45349551
21B cell mediated immunity (GO:0019724)3.41720276
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41029239
23mature B cell differentiation involved in immune response (GO:0002313)3.36632466
24response to thyroid hormone (GO:0097066)3.27870303
25positive regulation by symbiont of host defense response (GO:0052509)3.21206674
26modulation by symbiont of host defense response (GO:0052031)3.21206674
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21206674
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21206674
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.21206674
30modulation by symbiont of host immune response (GO:0052553)3.21206674
31regulation of gamma-delta T cell activation (GO:0046643)3.20275040
32glycosphingolipid catabolic process (GO:0046479)3.19528891
33regulation of gamma-delta T cell differentiation (GO:0045586)3.18762521
34negative regulation of granulocyte differentiation (GO:0030853)3.15531726
35neutrophil activation (GO:0042119)3.14361764
36regulation of hypersensitivity (GO:0002883)3.11988427
37negative regulation of interleukin-6 production (GO:0032715)3.10672156
38granulocyte activation (GO:0036230)3.09660558
39regulation of regulated secretory pathway (GO:1903305)3.09366234
40regulation of vitamin D biosynthetic process (GO:0060556)3.09325292
41detection of bacterium (GO:0016045)3.06466436
42detection of other organism (GO:0098543)3.06353527
43regulation of mast cell activation (GO:0033003)3.03228304
44regulation of vitamin metabolic process (GO:0030656)3.01104925
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00518775
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.00046640
47positive regulation of mast cell degranulation (GO:0043306)3.00046640
48regulation of female gonad development (GO:2000194)2.99469151
49regulation of antigen processing and presentation (GO:0002577)2.98410493
50myeloid cell activation involved in immune response (GO:0002275)2.97015258
51interferon-gamma-mediated signaling pathway (GO:0060333)2.96598876
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93886754
53positive regulation of antigen processing and presentation (GO:0002579)2.91976384
54macrophage activation involved in immune response (GO:0002281)2.91394662
55response to protozoan (GO:0001562)2.90804548
56NIK/NF-kappaB signaling (GO:0038061)2.90598108
57glycolipid catabolic process (GO:0019377)2.89354493
58reactive oxygen species biosynthetic process (GO:1903409)2.88172998
59negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86891693
60mucosal-associated lymphoid tissue development (GO:0048537)2.86436086
61Peyers patch development (GO:0048541)2.86436086
62negative regulation of interleukin-8 production (GO:0032717)2.86312472
63germinal center formation (GO:0002467)2.83224880
64definitive hemopoiesis (GO:0060216)2.82825376
65regulation of T-helper 1 cell differentiation (GO:0045625)2.81933779
66respiratory burst (GO:0045730)2.80269902
67negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.74027207
68modulation of growth of symbiont involved in interaction with host (GO:0044144)2.74027207
69regulation of growth of symbiont in host (GO:0044126)2.74027207
70negative regulation of growth of symbiont in host (GO:0044130)2.74027207
71negative regulation of myeloid cell apoptotic process (GO:0033033)2.72888808
72negative regulation of cytokine production involved in immune response (GO:0002719)2.72276865
73regulation of B cell apoptotic process (GO:0002902)2.72103070
74regulation of erythrocyte differentiation (GO:0045646)2.71188810
75purine deoxyribonucleotide catabolic process (GO:0009155)2.68892893
76response to hydroperoxide (GO:0033194)2.68433147
77positive regulation of megakaryocyte differentiation (GO:0045654)2.68195576
78B cell receptor signaling pathway (GO:0050853)2.67899217
79positive thymic T cell selection (GO:0045059)2.66824922
80regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.63182086
81barbed-end actin filament capping (GO:0051016)2.62448072
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62070098
83regulation of inflammatory response to antigenic stimulus (GO:0002861)2.61932804
84positive regulation of isotype switching (GO:0045830)2.61275259
85regulation of tumor necrosis factor production (GO:0032680)2.60515683
86Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60369628
87positive regulation of mast cell activation (GO:0033005)2.58814083
88leukocyte degranulation (GO:0043299)2.57679318
89positive regulation of granulocyte differentiation (GO:0030854)2.57267088
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.55689887
91negative regulation of tumor necrosis factor production (GO:0032720)2.54904253
92lipoxygenase pathway (GO:0019372)2.53829383
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52904502
94regulation of superoxide anion generation (GO:0032928)2.52230807
95antigen processing and presentation of endogenous antigen (GO:0019883)2.51816391
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.51344020
97regulation of granulocyte differentiation (GO:0030852)2.50548815
98negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.50212957
99oligosaccharide catabolic process (GO:0009313)2.49463368
100positive regulation of B cell activation (GO:0050871)2.49157607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.17804445
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.52363631
3VDR_21846776_ChIP-Seq_THP-1_Human3.86664906
4VDR_24763502_ChIP-Seq_THP-1_Human3.39515120
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.32311075
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.21207594
7SCL_19346495_ChIP-Seq_HPC-7_Human3.06754447
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06426975
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.90363763
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64944178
11MYC_22102868_ChIP-Seq_BL_Human2.53678702
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49565361
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.45719796
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42971248
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42653380
16SPI1_23547873_ChIP-Seq_NB4_Human2.40115890
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34325749
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31638120
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.30123285
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28619701
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.06345406
22MAF_26560356_Chip-Seq_TH1_Human2.04353144
23UTX_26944678_Chip-Seq_JUKART_Human2.01045292
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01034059
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00963080
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00483906
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99893841
28TCF7_22412390_ChIP-Seq_EML_Mouse1.97719978
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88698612
30SPI1_23127762_ChIP-Seq_K562_Human1.87371931
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87179975
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83846315
33MYB_26560356_Chip-Seq_TH2_Human1.83800641
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.73722959
35LXR_22292898_ChIP-Seq_THP-1_Human1.73473579
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70499885
37KDM2B_26808549_Chip-Seq_DND41_Human1.70015671
38GATA1_19941826_ChIP-Seq_K562_Human1.69840437
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68447218
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66384496
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64606742
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63301409
43VDR_24787735_ChIP-Seq_THP-1_Human1.62697218
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62200807
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61021592
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60767064
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58316101
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58082099
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56493683
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54606899
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.54053877
52MYB_26560356_Chip-Seq_TH1_Human1.53514651
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53071693
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52816080
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50854137
56GATA1_22025678_ChIP-Seq_K562_Human1.48889639
57MAF_26560356_Chip-Seq_TH2_Human1.47575637
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46544773
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46168522
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43306102
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42675230
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42252308
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41966004
64RUNX_20019798_ChIP-Seq_JUKART_Human1.39660897
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39497088
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38821501
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36157683
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.34693182
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34478258
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32711314
71NCOR1_26117541_ChIP-Seq_K562_Human1.29611237
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27430467
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26766467
74ZNF263_19887448_ChIP-Seq_K562_Human1.23635602
75* BCOR_27268052_Chip-Seq_Bcells_Human1.23163332
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21551827
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19858516
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19439919
79BCL6_27268052_Chip-Seq_Bcells_Human1.18243968
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18235193
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17366997
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15856272
83GATA2_19941826_ChIP-Seq_K562_Human1.15120074
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10260589
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07484882
86* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02897487
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02359197
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.00953872
89* P68_20966046_ChIP-Seq_HELA_Human1.00804409
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00387082
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98676918
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97349953
93GATA3_27048872_Chip-Seq_THYMUS_Human0.96974076
94SPI1_20517297_ChIP-Seq_HL60_Human0.96541679
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95814363
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95661103
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93823641
98PU_27001747_Chip-Seq_BMDM_Mouse0.93639819
99CIITA_25753668_ChIP-Seq_RAJI_Human0.91272586
100RACK7_27058665_Chip-Seq_MCF-7_Human0.89045527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to5.42635128
2MP0003303_peritoneal_inflammation4.23035649
3MP0005058_abnormal_lysosome_morphology3.50356495
4MP0001835_abnormal_antigen_presentation3.10631296
5MP0005397_hematopoietic_system_phenotyp3.01485436
6MP0001545_abnormal_hematopoietic_system3.01485436
7MP0002419_abnormal_innate_immunity2.94423009
8MP0003172_abnormal_lysosome_physiology2.85577922
9MP0005025_abnormal_response_to2.79792916
10MP0002148_abnormal_hypersensitivity_rea2.74184246
11MP0005000_abnormal_immune_tolerance2.67686177
12MP0005464_abnormal_platelet_physiology2.63846388
13MP0009278_abnormal_bone_marrow2.59664287
14MP0001533_abnormal_skeleton_physiology2.59610753
15MP0003300_gastrointestinal_ulcer2.58927030
16MP0003724_increased_susceptibility_to2.47621218
17MP0009785_altered_susceptibility_to2.29746902
18MP0002396_abnormal_hematopoietic_system2.14664899
19MP0002420_abnormal_adaptive_immunity2.11612588
20MP0001790_abnormal_immune_system2.11092338
21MP0005387_immune_system_phenotype2.11092338
22MP0001819_abnormal_immune_cell2.10412121
23MP0006082_CNS_inflammation2.09782567
24MP0003656_abnormal_erythrocyte_physiolo2.01167936
25MP0009840_abnormal_foam_cell1.99005079
26MP0002452_abnormal_antigen_presenting1.98935241
27MP0001800_abnormal_humoral_immune1.97527175
28MP0000465_gastrointestinal_hemorrhage1.96216117
29MP0003191_abnormal_cellular_cholesterol1.93419227
30MP0002723_abnormal_immune_serum1.92408331
31MP0010155_abnormal_intestine_physiology1.90140332
32MP0003075_altered_response_to1.80307124
33MP0001853_heart_inflammation1.75161040
34MP0005671_abnormal_response_to1.59925824
35MP0000716_abnormal_immune_system1.57588254
36MP0002398_abnormal_bone_marrow1.56986406
37MP0001845_abnormal_inflammatory_respons1.54558032
38MP0009764_decreased_sensitivity_to1.52959474
39MP0000604_amyloidosis1.52448825
40MP0004808_abnormal_hematopoietic_stem1.50710532
41MP0002405_respiratory_system_inflammati1.50609126
42MP0000685_abnormal_immune_system1.48042334
43MP0002998_abnormal_bone_remodeling1.44270673
44MP0004947_skin_inflammation1.43453558
45MP0008469_abnormal_protein_level1.41486701
46MP0000343_altered_response_to1.39137251
47MP0002429_abnormal_blood_cell1.37825743
48MP0000689_abnormal_spleen_morphology1.33285278
49MP0002139_abnormal_hepatobiliary_system1.32774677
50MP0002722_abnormal_immune_system1.31986694
51MP0005451_abnormal_body_composition1.31789032
52MP0005390_skeleton_phenotype1.31751765
53MP0002009_preneoplasia1.29431994
54MP0003448_altered_tumor_morphology1.26353426
55MP0009333_abnormal_splenocyte_physiolog1.23486370
56MP0003763_abnormal_thymus_physiology1.19601892
57MP0001851_eye_inflammation1.18670591
58MP0005166_decreased_susceptibility_to1.17509497
59MP0003828_pulmonary_edema1.16840138
60MP0003183_abnormal_peptide_metabolism1.15772216
61MP0008004_abnormal_stomach_pH1.14686762
62MP0005666_abnormal_adipose_tissue1.10756060
63MP0001663_abnormal_digestive_system1.08068915
64MP0004185_abnormal_adipocyte_glucose1.06908859
65MP0003806_abnormal_nucleotide_metabolis1.02985423
66MP0000858_altered_metastatic_potential1.00397329
67MP0002166_altered_tumor_susceptibility1.00097526
68MP0009763_increased_sensitivity_to0.96729682
69MP0003453_abnormal_keratinocyte_physiol0.94115196
70MP0009765_abnormal_xenobiotic_induced0.93759433
71MP0009379_abnormal_foot_pigmentation0.93707726
72MP0004510_myositis0.92241186
73MP0003866_abnormal_defecation0.91647062
74MP0004147_increased_porphyrin_level0.90753935
75MP0001873_stomach_inflammation0.89538583
76MP0004782_abnormal_surfactant_physiolog0.89418168
77MP0005535_abnormal_body_temperature0.88231426
78MP0003329_amyloid_beta_deposits0.87063608
79MP0008260_abnormal_autophagy0.83133223
80MP0005164_abnormal_response_to0.81242192
81MP0002877_abnormal_melanocyte_morpholog0.80386104
82MP0000703_abnormal_thymus_morphology0.80085856
83MP0005165_increased_susceptibility_to0.78940388
84MP0001764_abnormal_homeostasis0.77871613
85MP0000490_abnormal_crypts_of0.76764275
86MP0003795_abnormal_bone_structure0.76600025
87MP0002132_abnormal_respiratory_system0.76040694
88MP0002933_joint_inflammation0.73525146
89MP0005319_abnormal_enzyme/_coenzyme0.70409615
90MP0000249_abnormal_blood_vessel0.69585772
91MP0002006_tumorigenesis0.69278983
92MP0005584_abnormal_enzyme/coenzyme_acti0.69028804
93MP0009115_abnormal_fat_cell0.68013702
94MP0005381_digestive/alimentary_phenotyp0.65924348
95MP0002019_abnormal_tumor_incidence0.65167754
96MP0005310_abnormal_salivary_gland0.63463497
97MP0010307_abnormal_tumor_latency0.62592695
98MP0005334_abnormal_fat_pad0.61967054
99MP0002971_abnormal_brown_adipose0.59606153
100MP0009931_abnormal_skin_appearance0.59583305

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.91323593
2Abnormality of liposaccharide metabolism (HP:0010968)4.91323593
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.91323593
4Recurrent abscess formation (HP:0002722)4.48375356
5Recurrent bacterial skin infections (HP:0005406)4.31729475
6Abnormality of macrophages (HP:0004311)4.09395692
7Dysostosis multiplex (HP:0000943)4.05812864
8Petechiae (HP:0000967)4.00273169
9Prolonged bleeding time (HP:0003010)3.99822163
10Eczematoid dermatitis (HP:0000976)3.95985654
11Vacuolated lymphocytes (HP:0001922)3.92479151
12Elevated erythrocyte sedimentation rate (HP:0003565)3.91184656
13Myositis (HP:0100614)3.88594768
14Panhypogammaglobulinemia (HP:0003139)3.76031687
15Agammaglobulinemia (HP:0004432)3.74674569
16Increased cerebral lipofuscin (HP:0011813)3.67786974
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.55519417
18Autoimmune thrombocytopenia (HP:0001973)3.45618253
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.44509768
20Obstructive lung disease (HP:0006536)3.43440499
21Chronic obstructive pulmonary disease (HP:0006510)3.43440499
22Recurrent viral infections (HP:0004429)3.41588999
23Systemic lupus erythematosus (HP:0002725)3.38314059
24Increased IgE level (HP:0003212)3.28781721
25Recurrent fungal infections (HP:0002841)3.26082312
26Stomatitis (HP:0010280)3.18252252
27Acute lymphatic leukemia (HP:0006721)3.08614921
28Mediastinal lymphadenopathy (HP:0100721)3.07010999
29Recurrent skin infections (HP:0001581)3.04495470
30Epistaxis (HP:0000421)3.01970344
31Colitis (HP:0002583)3.01364347
32Recurrent cutaneous fungal infections (HP:0011370)2.98993471
33Chronic mucocutaneous candidiasis (HP:0002728)2.98993471
34Cellulitis (HP:0100658)2.97747282
35Purpura (HP:0000979)2.95487547
36Thrombocytosis (HP:0001894)2.95457855
37Meningitis (HP:0001287)2.92458922
38Thoracic kyphosis (HP:0002942)2.87881977
39Recurrent gram-negative bacterial infections (HP:0005420)2.84138751
40Increased serum ferritin (HP:0003281)2.81685361
41Orchitis (HP:0100796)2.79654593
42Encephalitis (HP:0002383)2.76874412
43Inflammation of the large intestine (HP:0002037)2.75447407
44Hepatosplenomegaly (HP:0001433)2.75183781
45Abnormality of the prostate (HP:0008775)2.72120132
46Gastrointestinal inflammation (HP:0004386)2.69699045
47Viral hepatitis (HP:0006562)2.62260708
48Interstitial pulmonary disease (HP:0006530)2.62038063
49Polygenic inheritance (HP:0010982)2.59110614
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54833386
51Abnormality of polysaccharide metabolism (HP:0011012)2.54833386
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54833386
53Osteomyelitis (HP:0002754)2.54669037
54Acute myeloid leukemia (HP:0004808)2.54140887
55Autoimmune hemolytic anemia (HP:0001890)2.52698984
56Abnormality of T cell physiology (HP:0011840)2.49792504
57Hypergammaglobulinemia (HP:0010702)2.46739914
58Abnormality of iron homeostasis (HP:0011031)2.46337664
59Urticaria (HP:0001025)2.45242690
60Mucopolysacchariduria (HP:0008155)2.44371755
61Urinary glycosaminoglycan excretion (HP:0003541)2.44371755
62Spontaneous hematomas (HP:0007420)2.43103976
63Prostate neoplasm (HP:0100787)2.39083390
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.36161014
65Abnormality of B cell number (HP:0010975)2.35232544
66Retrobulbar optic neuritis (HP:0100654)2.32530962
67Optic neuritis (HP:0100653)2.32530962
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30807376
69Gingivitis (HP:0000230)2.30292803
70Hypertensive crisis (HP:0100735)2.30088013
71Disinhibition (HP:0000734)2.25572818
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23660596
73Mutism (HP:0002300)2.23284364
74Loss of speech (HP:0002371)2.21562020
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20452044
76Hematochezia (HP:0002573)2.19280132
77B lymphocytopenia (HP:0010976)2.16048224
78Abnormality of complement system (HP:0005339)2.15326218
79Granulocytopenia (HP:0001913)2.14755177
80Vasculitis (HP:0002633)2.13593370
81Amyloidosis (HP:0011034)2.11378913
82Leukocytosis (HP:0001974)2.07321334
83Abnormality of the thoracic spine (HP:0100711)2.07049359
84Abnormal platelet function (HP:0011869)2.03963772
85Impaired platelet aggregation (HP:0003540)2.03963772
86Episodic fever (HP:0001954)2.02479772
87Pulmonary infiltrates (HP:0002113)2.01421585
88Increased IgM level (HP:0003496)2.01224151
89Gingival bleeding (HP:0000225)1.98666229
90Chronic otitis media (HP:0000389)1.97707868
91Abnormality of the periventricular white matter (HP:0002518)1.97553373
92Abnormality of transition element cation homeostasis (HP:0011030)1.96710370
93Skin rash (HP:0000988)1.96578742
94Axonal loss (HP:0003447)1.95591363
95Polycythemia (HP:0001901)1.95524295
96Abnormality of the lumbar spine (HP:0100712)1.95113845
97Abnormality of T cells (HP:0002843)1.92461776
98Progressive neurologic deterioration (HP:0002344)1.91828663
99Hemoptysis (HP:0002105)1.88016490
100Stomach cancer (HP:0012126)1.84037554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.05079146
2RIPK43.65946079
3PRPF4B3.57095747
4KIT3.43191198
5FES3.33303651
6ERN12.85185521
7TBK12.50675898
8MAP4K12.48397933
9MAP2K32.40817799
10MATK2.27468695
11MAP3K112.22487803
12BLK2.03573565
13TRIB31.91693673
14MAP3K141.90175354
15TYK21.86308565
16TAOK21.83518282
17TNK21.82290245
18MAP3K131.73161175
19BTK1.72128035
20CDK61.70043718
21IKBKB1.64228250
22FLT31.63518698
23CSF1R1.63347725
24BMPR21.62869392
25IRAK31.61891069
26ZAP701.60280137
27TEC1.57083749
28IKBKE1.51483735
29GRK61.49494318
30SYK1.46770499
31JAK31.41797408
32TESK21.39585527
33KDR1.34518587
34LYN1.27731437
35MAP3K31.23325387
36MAP3K11.21618591
37MAP3K61.19389994
38IRAK41.18058462
39HCK1.17495909
40MOS1.16756369
41GRK71.15458937
42TAOK11.12141132
43CDK41.12040866
44PIM21.12022826
45RPS6KA41.08833139
46TGFBR21.04715815
47CSK1.04566551
48ABL21.04222487
49EEF2K1.03753557
50BCKDK1.00635761
51PKN20.95813643
52JAK20.93657448
53LCK0.91425708
54ITK0.88328947
55TXK0.88254671
56MAP2K20.86777852
57LRRK20.83971738
58HIPK20.81013052
59PDPK10.76474503
60TAOK30.76412116
61SCYL20.75278715
62MARK20.69128289
63PDK10.68372542
64PIM10.67112120
65FGR0.65624350
66MAPK150.64164220
67ARAF0.64144134
68RPS6KL10.63661576
69RPS6KC10.63661576
70JAK10.59480073
71CDC42BPA0.57406583
72IRAK10.56118656
73BMX0.55876282
74MAPK40.51451540
75STK100.51266848
76TRPM70.51263346
77CDK190.50983975
78RPS6KA60.49281081
79SIK30.48156378
80RPS6KA20.46771389
81MAP3K50.46208321
82MAPK30.44149851
83PRKCQ0.40119612
84RIPK10.39314589
85GSK3A0.38735876
86MARK30.38312978
87RET0.37597311
88MAP3K80.37564624
89IRAK20.36645988
90ABL10.36552669
91TGFBR10.35733126
92DDR20.35647980
93MAP3K70.33485563
94MAPK120.31532136
95MAP2K60.31130916
96TTN0.30955162
97CHUK0.30022493
98MAPKAPK20.29058466
99FYN0.26976942
100PTK60.26625204

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.18392760
2Asthma_Homo sapiens_hsa053103.79744443
3Leishmaniasis_Homo sapiens_hsa051403.12639616
4Staphylococcus aureus infection_Homo sapiens_hsa051502.87722420
5Allograft rejection_Homo sapiens_hsa053302.74621175
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.43765684
7Osteoclast differentiation_Homo sapiens_hsa043802.33489346
8Autoimmune thyroid disease_Homo sapiens_hsa053202.28486144
9Graft-versus-host disease_Homo sapiens_hsa053322.25293454
10Acute myeloid leukemia_Homo sapiens_hsa052212.24463384
11Rheumatoid arthritis_Homo sapiens_hsa053232.07207650
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01249688
13Hematopoietic cell lineage_Homo sapiens_hsa046401.99598520
14Malaria_Homo sapiens_hsa051441.97564346
15Tuberculosis_Homo sapiens_hsa051521.97347146
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82627892
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.81756604
18Type I diabetes mellitus_Homo sapiens_hsa049401.78119344
19Lysosome_Homo sapiens_hsa041421.76793407
20Pertussis_Homo sapiens_hsa051331.75243582
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72374610
22B cell receptor signaling pathway_Homo sapiens_hsa046621.69646583
23Antigen processing and presentation_Homo sapiens_hsa046121.67263095
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65424992
25Legionellosis_Homo sapiens_hsa051341.59851613
26Toxoplasmosis_Homo sapiens_hsa051451.58802660
27Influenza A_Homo sapiens_hsa051641.50543897
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50472693
29TNF signaling pathway_Homo sapiens_hsa046681.49864836
30Primary immunodeficiency_Homo sapiens_hsa053401.47618828
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.44949608
32African trypanosomiasis_Homo sapiens_hsa051431.36670312
33Salmonella infection_Homo sapiens_hsa051321.32722984
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29547618
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27600129
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26529679
37Herpes simplex infection_Homo sapiens_hsa051681.22015082
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20588494
39Viral myocarditis_Homo sapiens_hsa054161.20558813
40Phagosome_Homo sapiens_hsa041451.16049662
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15807257
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12635032
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11547378
44Platelet activation_Homo sapiens_hsa046111.06894439
45Pentose phosphate pathway_Homo sapiens_hsa000300.96527348
46Hepatitis B_Homo sapiens_hsa051610.96157121
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93710192
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.91035927
49Measles_Homo sapiens_hsa051620.90265101
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89470046
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86623509
52Chemokine signaling pathway_Homo sapiens_hsa040620.86251017
53Shigellosis_Homo sapiens_hsa051310.86006380
54Amoebiasis_Homo sapiens_hsa051460.85079318
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82464680
56Chronic myeloid leukemia_Homo sapiens_hsa052200.81916736
57Hepatitis C_Homo sapiens_hsa051600.76025879
58Sulfur metabolism_Homo sapiens_hsa009200.72285901
59Renin-angiotensin system_Homo sapiens_hsa046140.72018287
60T cell receptor signaling pathway_Homo sapiens_hsa046600.71920899
61Epstein-Barr virus infection_Homo sapiens_hsa051690.66095381
62VEGF signaling pathway_Homo sapiens_hsa043700.64106781
63Apoptosis_Homo sapiens_hsa042100.64042259
64Pancreatic cancer_Homo sapiens_hsa052120.62372959
65Arachidonic acid metabolism_Homo sapiens_hsa005900.61337368
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.58932335
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58855851
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58694313
69Bladder cancer_Homo sapiens_hsa052190.57340094
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54798489
71Vitamin digestion and absorption_Homo sapiens_hsa049770.52824796
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.52432859
73Fructose and mannose metabolism_Homo sapiens_hsa000510.51070956
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48586917
75Prolactin signaling pathway_Homo sapiens_hsa049170.47698805
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.46327644
77Ribosome_Homo sapiens_hsa030100.45471876
78Non-small cell lung cancer_Homo sapiens_hsa052230.45172287
79HTLV-I infection_Homo sapiens_hsa051660.44993749
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43550021
81Galactose metabolism_Homo sapiens_hsa000520.43020511
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40540907
83Glutathione metabolism_Homo sapiens_hsa004800.38438851
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.38152393
85Systemic lupus erythematosus_Homo sapiens_hsa053220.37588116
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.37312282
87Collecting duct acid secretion_Homo sapiens_hsa049660.36243452
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35120506
89Insulin resistance_Homo sapiens_hsa049310.32437443
90GnRH signaling pathway_Homo sapiens_hsa049120.30012863
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29625885
92Prion diseases_Homo sapiens_hsa050200.28737352
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28711269
94Sphingolipid metabolism_Homo sapiens_hsa006000.27693417
95Viral carcinogenesis_Homo sapiens_hsa052030.26847225
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25087890
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.24201715
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.23809325
99Dorso-ventral axis formation_Homo sapiens_hsa043200.23359256
100Endocytosis_Homo sapiens_hsa041440.22628783

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