TPSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.73155826
2behavioral response to nicotine (GO:0035095)5.55884548
3pyrimidine nucleobase catabolic process (GO:0006208)5.09628281
4viral transcription (GO:0019083)5.03825200
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.92823578
6translational termination (GO:0006415)4.82913874
7neuron recognition (GO:0008038)4.80886414
8axon ensheathment in central nervous system (GO:0032291)4.75563368
9central nervous system myelination (GO:0022010)4.75563368
10angiotensin maturation (GO:0002003)4.74297681
11substrate-independent telencephalic tangential migration (GO:0021826)4.70865584
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.70865584
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62039447
14ATP synthesis coupled proton transport (GO:0015986)4.62039447
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.40830489
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.31097212
17nucleobase catabolic process (GO:0046113)4.26084709
18vocalization behavior (GO:0071625)4.24720349
19glutamate receptor signaling pathway (GO:0007215)4.23195310
20positive regulation of mast cell activation involved in immune response (GO:0033008)4.15774596
21positive regulation of mast cell degranulation (GO:0043306)4.15774596
22dendritic spine morphogenesis (GO:0060997)4.08079791
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06854870
24axonal fasciculation (GO:0007413)3.95957984
25neurofilament cytoskeleton organization (GO:0060052)3.85657068
26ribosomal small subunit assembly (GO:0000028)3.85371791
27positive regulation of synapse assembly (GO:0051965)3.84797576
28cotranslational protein targeting to membrane (GO:0006613)3.84559189
29protein localization to synapse (GO:0035418)3.83402248
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82923298
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.82159867
32protein targeting to ER (GO:0045047)3.80477764
33translational elongation (GO:0006414)3.77904877
34cellular protein complex disassembly (GO:0043624)3.73310767
35sequestering of actin monomers (GO:0042989)3.72159639
36presynaptic membrane assembly (GO:0097105)3.71923150
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.70748180
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65137299
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58833036
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58407584
41viral life cycle (GO:0019058)3.58323575
42membrane repolarization during action potential (GO:0086011)3.56842598
43limb bud formation (GO:0060174)3.55729568
44presynaptic membrane organization (GO:0097090)3.55537671
45protein localization to endoplasmic reticulum (GO:0070972)3.52747473
46neuron remodeling (GO:0016322)3.52295282
47transmission of nerve impulse (GO:0019226)3.49132168
48positive regulation of gastrulation (GO:2000543)3.48963938
49ribosomal small subunit biogenesis (GO:0042274)3.37177290
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36801678
51respiratory electron transport chain (GO:0022904)3.36242951
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34050775
53response to histamine (GO:0034776)3.32602875
54positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.29263458
55positive regulation of mast cell activation (GO:0033005)3.29210878
56electron transport chain (GO:0022900)3.26528227
57membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26198393
58membrane repolarization (GO:0086009)3.24653808
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24296053
60synaptic transmission, glutamatergic (GO:0035249)3.23063478
61cell proliferation in forebrain (GO:0021846)3.20652173
62auditory behavior (GO:0031223)3.20506035
63protein complex disassembly (GO:0043241)3.19484896
64mating behavior (GO:0007617)3.13008677
65lateral sprouting from an epithelium (GO:0060601)3.11732123
66neuron-neuron synaptic transmission (GO:0007270)3.11607287
67forebrain neuron differentiation (GO:0021879)3.09276582
68regulation of glutamate receptor signaling pathway (GO:1900449)3.07295836
69spinal cord association neuron differentiation (GO:0021527)3.06879205
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.06715480
71NADH dehydrogenase complex assembly (GO:0010257)3.06715480
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06715480
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05978055
74regulation of glutamate secretion (GO:0014048)3.05010692
75positive regulation of respiratory burst (GO:0060267)3.04993179
76startle response (GO:0001964)3.04787575
77synaptic transmission, cholinergic (GO:0007271)3.03757412
78layer formation in cerebral cortex (GO:0021819)2.99861178
79macromolecular complex disassembly (GO:0032984)2.99466847
80regulation of hypersensitivity (GO:0002883)2.99144592
81nephron tubule morphogenesis (GO:0072078)2.99018099
82nephron epithelium morphogenesis (GO:0072088)2.99018099
83regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.97615232
84protein complex biogenesis (GO:0070271)2.97512422
85postsynaptic membrane organization (GO:0001941)2.95489630
86nonmotile primary cilium assembly (GO:0035058)2.94917409
87regulation of synapse assembly (GO:0051963)2.92862084
88mechanosensory behavior (GO:0007638)2.92761344
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92316986
90membrane hyperpolarization (GO:0060081)2.91216113
91maturation of SSU-rRNA (GO:0030490)2.88634691
92regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.85086140
93positive regulation of action potential (GO:0045760)2.84665233
94synaptic vesicle exocytosis (GO:0016079)2.83892526
95positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83544271
96righting reflex (GO:0060013)2.83041001
97spinal cord development (GO:0021510)2.80234779
98regulation of respiratory system process (GO:0044065)2.77949595
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77856406
100retinal ganglion cell axon guidance (GO:0031290)2.77457611
101keratinocyte development (GO:0003334)2.77374255
102neuronal action potential propagation (GO:0019227)2.76669877
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75518790
104neuron fate determination (GO:0048664)2.75175087
105somite development (GO:0061053)2.73726057
106dendrite development (GO:0016358)2.73592792
107response to auditory stimulus (GO:0010996)2.72959132
108adult walking behavior (GO:0007628)2.71904033
109thalamus development (GO:0021794)2.71365165
110regulation of synapse structural plasticity (GO:0051823)2.71031824
111establishment of mitochondrion localization (GO:0051654)2.69644049
112cochlea development (GO:0090102)2.68950539
113chaperone-mediated protein transport (GO:0072321)2.68247175
114epithelial cilium movement (GO:0003351)2.68176258
115exploration behavior (GO:0035640)2.67913391
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67805613
117regulation of postsynaptic membrane potential (GO:0060078)2.65991342
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65960101
119membrane depolarization during action potential (GO:0086010)2.65654619
120head development (GO:0060322)2.65646022
121mitochondrial respiratory chain complex assembly (GO:0033108)2.64771260
122GTP biosynthetic process (GO:0006183)2.64404070
123protein neddylation (GO:0045116)2.63233438
124translational initiation (GO:0006413)2.62993091
125protein targeting to membrane (GO:0006612)2.60574969
126positive regulation of leukocyte degranulation (GO:0043302)2.59797266
127positive regulation of dendritic spine development (GO:0060999)2.59654149
128hindbrain development (GO:0030902)2.57763737
129retina layer formation (GO:0010842)2.56533887
130pattern specification involved in kidney development (GO:0061004)2.55515843
131regulation of catecholamine metabolic process (GO:0042069)2.54959349
132regulation of dopamine metabolic process (GO:0042053)2.54959349
133regulation of membrane repolarization (GO:0060306)2.54819402
134short-term memory (GO:0007614)2.54656373
135negative regulation of microtubule polymerization (GO:0031115)2.53796595
136long-chain fatty acid biosynthetic process (GO:0042759)2.51801479
137axon extension (GO:0048675)2.51706918
138cerebral cortex radially oriented cell migration (GO:0021799)2.50740138
139regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50672459
140regulation of respiratory gaseous exchange (GO:0043576)2.50082169
141regulation of glycogen (starch) synthase activity (GO:2000465)2.49919022
142regulation of dendritic spine morphogenesis (GO:0061001)2.49080644
143synapse assembly (GO:0007416)2.48513981
144positive regulation of potassium ion transmembrane transport (GO:1901381)2.48442846
145cell migration in hindbrain (GO:0021535)2.48193975
146neuronal action potential (GO:0019228)2.47347590
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47176938
148long-term memory (GO:0007616)2.47006385
149establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46288351
150mitochondrion transport along microtubule (GO:0047497)2.46288351
151positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.46264171
152fear response (GO:0042596)2.46224516
153synaptic transmission, dopaminergic (GO:0001963)2.45951237
154negative regulation of astrocyte differentiation (GO:0048712)2.45645144
155regulation of feeding behavior (GO:0060259)2.45308109
156dopamine biosynthetic process (GO:0042416)2.44774426
157membrane depolarization (GO:0051899)2.44231592
158negative regulation of neurotransmitter transport (GO:0051589)2.43889465
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43842274
160serotonin metabolic process (GO:0042428)2.43344737
161regulation of long-term neuronal synaptic plasticity (GO:0048169)2.42977910
162central nervous system projection neuron axonogenesis (GO:0021952)2.42691389
163response to cocaine (GO:0042220)2.42646295
164innervation (GO:0060384)2.41967355
165regulation of synapse organization (GO:0050807)2.41441218
166purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41013035
167neurotransmitter uptake (GO:0001504)2.40270722
168behavioral response to cocaine (GO:0048148)2.40077964
169histone H2B ubiquitination (GO:0033523)2.39619094
170kidney morphogenesis (GO:0060993)2.39210555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84113290
2GBX2_23144817_ChIP-Seq_PC3_Human3.56352265
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10666435
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00168065
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92919303
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.91961305
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87970653
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.81352391
9TAF15_26573619_Chip-Seq_HEK293_Human2.69027333
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62537035
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60866307
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59909698
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59909698
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56908366
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.53905119
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.53393968
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48698640
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25768157
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24906286
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24471821
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.20212213
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17108409
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13775417
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12169256
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11035126
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.08167823
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07145311
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.06925456
29VDR_22108803_ChIP-Seq_LS180_Human2.01899492
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96200936
31REST_21632747_ChIP-Seq_MESCs_Mouse1.92866535
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90410411
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89795376
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89471136
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88014116
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86762524
37AR_21572438_ChIP-Seq_LNCaP_Human1.84915540
38RNF2_27304074_Chip-Seq_NSC_Mouse1.83229446
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78446170
40P300_19829295_ChIP-Seq_ESCs_Human1.77725800
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73256242
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.72803443
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63300900
44ZNF274_21170338_ChIP-Seq_K562_Hela1.61534433
45FUS_26573619_Chip-Seq_HEK293_Human1.58859281
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55938425
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55902091
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55482066
49DROSHA_22980978_ChIP-Seq_HELA_Human1.53744011
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48549132
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42803192
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.41310737
53SMAD4_21799915_ChIP-Seq_A2780_Human1.41137338
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.40188178
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39760375
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37533393
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36831821
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35915317
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33724320
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33570353
61ER_23166858_ChIP-Seq_MCF-7_Human1.32897600
62CTCF_27219007_Chip-Seq_Bcells_Human1.30036098
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28295933
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.27879785
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.26993979
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26372495
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26023451
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26023451
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24335330
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23197979
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.21307957
72IGF1R_20145208_ChIP-Seq_DFB_Human1.21252420
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19768165
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.18661434
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17488725
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13696325
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13675617
78BCAT_22108803_ChIP-Seq_LS180_Human1.12806957
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.11216780
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11125257
81EWS_26573619_Chip-Seq_HEK293_Human1.09952302
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09942908
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.08033405
84RUNX2_22187159_ChIP-Seq_PCA_Human1.07217376
85* ERG_21242973_ChIP-ChIP_JURKAT_Human1.07049678
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.06820635
87TP53_18474530_ChIP-ChIP_U2OS_Human1.06473404
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05980854
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.05137556
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04683257
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04293483
92AR_25329375_ChIP-Seq_VCAP_Human1.03968357
93KDM2B_26808549_Chip-Seq_REH_Human1.02104553
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01936170
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01639103
96AHR_22903824_ChIP-Seq_MCF-7_Human1.01431228
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01025253
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00821905
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99566396
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98341413
101NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97621084
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96847664
103SOX2_21211035_ChIP-Seq_LN229_Gbm0.96195987
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.95390008
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95298397
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.95093308
107JUN_21703547_ChIP-Seq_K562_Human0.94729447
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.94140430
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91574859
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91073258
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89277835
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89153684
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.88695865
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88271016
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88152302
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.88032864
117STAT3_23295773_ChIP-Seq_U87_Human0.87545035
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.86646300
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86277222
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.86045461
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84132064
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83128288
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80349942
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77960496
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77529465
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76910412
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76680228
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76551423
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76223472
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74517113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.13889341
2MP0005423_abnormal_somatic_nervous3.76590551
3MP0006276_abnormal_autonomic_nervous3.00640125
4MP0004859_abnormal_synaptic_plasticity2.81392548
5MP0003635_abnormal_synaptic_transmissio2.74090749
6MP0001968_abnormal_touch/_nociception2.60303333
7MP0003123_paternal_imprinting2.57337006
8MP0004270_analgesia2.56345810
9MP0009745_abnormal_behavioral_response2.49875410
10MP0001440_abnormal_grooming_behavior2.42814248
11MP0001486_abnormal_startle_reflex2.41394454
12MP0001188_hyperpigmentation2.37846389
13MP0002572_abnormal_emotion/affect_behav2.37165293
14MP0003121_genomic_imprinting2.36776098
15MP0000778_abnormal_nervous_system2.36698400
16MP0002736_abnormal_nociception_after2.36346968
17MP0002272_abnormal_nervous_system2.35858537
18MP0002735_abnormal_chemical_nociception2.31141604
19MP0001529_abnormal_vocalization2.30205563
20MP0002063_abnormal_learning/memory/cond2.26277260
21MP0002064_seizures2.24417554
22MP0002734_abnormal_mechanical_nocicepti2.20646757
23MP0003283_abnormal_digestive_organ2.17955816
24MP0004742_abnormal_vestibular_system2.17316008
25MP0009379_abnormal_foot_pigmentation2.12686288
26MP0005645_abnormal_hypothalamus_physiol2.06519910
27MP0001501_abnormal_sleep_pattern2.03258394
28MP0002102_abnormal_ear_morphology2.01993974
29MP0002184_abnormal_innervation1.91479606
30MP0001984_abnormal_olfaction1.86237608
31MP0002067_abnormal_sensory_capabilities1.85509151
32MP0001970_abnormal_pain_threshold1.83592281
33MP0003890_abnormal_embryonic-extraembry1.80044539
34MP0009046_muscle_twitch1.71678160
35MP0002733_abnormal_thermal_nociception1.69886429
36MP0001905_abnormal_dopamine_level1.67653393
37MP0006072_abnormal_retinal_apoptosis1.61401570
38MP0002557_abnormal_social/conspecific_i1.60611169
39MP0003136_yellow_coat_color1.60252752
40MP0003938_abnormal_ear_development1.59700983
41MP0006292_abnormal_olfactory_placode1.59135834
42MP0005646_abnormal_pituitary_gland1.58875148
43MP0005551_abnormal_eye_electrophysiolog1.58525559
44MP0004142_abnormal_muscle_tone1.55684327
45MP0008877_abnormal_DNA_methylation1.52070606
46MP0005386_behavior/neurological_phenoty1.49283921
47MP0004924_abnormal_behavior1.49283921
48MP0005409_darkened_coat_color1.48713656
49MP0000026_abnormal_inner_ear1.46784515
50MP0002653_abnormal_ependyma_morphology1.45164479
51MP0004885_abnormal_endolymph1.36947510
52MP0003011_delayed_dark_adaptation1.34126863
53MP0002882_abnormal_neuron_morphology1.33987490
54MP0001485_abnormal_pinna_reflex1.33678651
55MP0000631_abnormal_neuroendocrine_gland1.30741482
56MP0003122_maternal_imprinting1.30314449
57MP0002752_abnormal_somatic_nervous1.28795298
58MP0001963_abnormal_hearing_physiology1.27088918
59MP0002909_abnormal_adrenal_gland1.22074351
60MP0000955_abnormal_spinal_cord1.20242522
61MP0002938_white_spotting1.19224019
62MP0001664_abnormal_digestion1.17392973
63MP0001502_abnormal_circadian_rhythm1.16972431
64MP0002163_abnormal_gland_morphology1.16941495
65MP0002638_abnormal_pupillary_reflex1.16638277
66MP0001293_anophthalmia1.15800052
67MP0002066_abnormal_motor_capabilities/c1.15417172
68MP0003119_abnormal_digestive_system1.14920957
69MP0002277_abnormal_respiratory_mucosa1.12842958
70MP0000462_abnormal_digestive_system1.11780120
71MP0000049_abnormal_middle_ear1.08005058
72MP0000566_synostosis1.06631316
73MP0003942_abnormal_urinary_system1.06018230
74MP0002928_abnormal_bile_duct1.05271003
75MP0002152_abnormal_brain_morphology1.04573242
76MP0003329_amyloid_beta_deposits1.00872266
77MP0010386_abnormal_urinary_bladder0.99473568
78MP0002751_abnormal_autonomic_nervous0.99248754
79MP0002837_dystrophic_cardiac_calcinosis0.98314522
80MP0000920_abnormal_myelination0.97854654
81MP0010030_abnormal_orbit_morphology0.97705478
82MP0004019_abnormal_vitamin_homeostasis0.92735101
83MP0003634_abnormal_glial_cell0.92654739
84MP0000751_myopathy0.92108084
85MP0001286_abnormal_eye_development0.91813731
86MP0004085_abnormal_heartbeat0.91740796
87MP0002229_neurodegeneration0.91054907
88MP0005377_hearing/vestibular/ear_phenot0.89074704
89MP0003878_abnormal_ear_physiology0.89074704
90MP0008569_lethality_at_weaning0.88546746
91MP0002160_abnormal_reproductive_system0.88498417
92MP0005195_abnormal_posterior_eye0.87400868
93MP0005253_abnormal_eye_physiology0.86392554
94MP0003646_muscle_fatigue0.85758471
95MP0008789_abnormal_olfactory_epithelium0.85377139
96MP0005394_taste/olfaction_phenotype0.84743305
97MP0005499_abnormal_olfactory_system0.84743305
98MP0004145_abnormal_muscle_electrophysio0.83980284
99MP0000537_abnormal_urethra_morphology0.83338418
100MP0003861_abnormal_nervous_system0.79800684
101MP0001986_abnormal_taste_sensitivity0.78555620
102MP0003137_abnormal_impulse_conducting0.78047255
103MP0002822_catalepsy0.77980595
104MP0005084_abnormal_gallbladder_morpholo0.77925963
105MP0004811_abnormal_neuron_physiology0.77633519
106MP0009250_abnormal_appendicular_skeleto0.76977892
107MP0003879_abnormal_hair_cell0.75833151
108MP0000569_abnormal_digit_pigmentation0.75448424
109MP0001944_abnormal_pancreas_morphology0.74478014
110MP0000534_abnormal_ureter_morphology0.74049161
111MP0003385_abnormal_body_wall0.73321724
112MP0004858_abnormal_nervous_system0.73061521
113MP0003315_abnormal_perineum_morphology0.72555155
114MP0005379_endocrine/exocrine_gland_phen0.70740014
115MP0003755_abnormal_palate_morphology0.70354432
116MP0001727_abnormal_embryo_implantation0.70264080
117MP0002876_abnormal_thyroid_physiology0.70222219
118MP0001943_abnormal_respiration0.68103756
119MP0002069_abnormal_eating/drinking_beha0.67295289
120MP0002282_abnormal_trachea_morphology0.66994130
121MP0000538_abnormal_urinary_bladder0.66271825
122MP0004133_heterotaxia0.65268596
123MP0003787_abnormal_imprinting0.62849986
124MP0003937_abnormal_limbs/digits/tail_de0.61430960
125MP0008872_abnormal_physiological_respon0.61319094
126MP0005171_absent_coat_pigmentation0.60310429

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.26824436
2Abnormality of cells of the erythroid lineage (HP:0012130)3.75608019
3Reticulocytopenia (HP:0001896)3.73063391
4Focal seizures (HP:0007359)3.56450601
5Acute necrotizing encephalopathy (HP:0006965)3.53595936
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.51790205
7Absent/shortened dynein arms (HP:0200106)3.51790205
8Molar tooth sign on MRI (HP:0002419)3.47286708
9Abnormality of midbrain morphology (HP:0002418)3.47286708
10Abnormal number of erythroid precursors (HP:0012131)3.40993865
11Atonic seizures (HP:0010819)3.33290123
12Abnormal ciliary motility (HP:0012262)3.24772150
13Macrocytic anemia (HP:0001972)3.19171011
14Increased hepatocellular lipid droplets (HP:0006565)3.14845726
15Progressive macrocephaly (HP:0004481)3.13838138
16Hyperventilation (HP:0002883)3.11614854
17Renal Fanconi syndrome (HP:0001994)3.07345590
18Myokymia (HP:0002411)3.06519878
19Neurofibrillary tangles (HP:0002185)3.02883330
20Mitochondrial inheritance (HP:0001427)3.02380899
21Humeroradial synostosis (HP:0003041)2.98047817
22Synostosis involving the elbow (HP:0003938)2.98047817
23Nephronophthisis (HP:0000090)2.97149973
24Abnormal respiratory epithelium morphology (HP:0012253)2.97088792
25Abnormal respiratory motile cilium morphology (HP:0005938)2.97088792
26Agitation (HP:0000713)2.96510150
27Hepatoblastoma (HP:0002884)2.96141700
28Decreased circulating renin level (HP:0003351)2.95026408
29Retinal dysplasia (HP:0007973)2.86593599
30Hemiparesis (HP:0001269)2.85869244
31Absence seizures (HP:0002121)2.84554106
32Pancreatic fibrosis (HP:0100732)2.80317665
33Limb dystonia (HP:0002451)2.78264237
34Abnormal mitochondria in muscle tissue (HP:0008316)2.77161096
35Epileptic encephalopathy (HP:0200134)2.75722321
36Abnormal respiratory motile cilium physiology (HP:0012261)2.74852898
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72575856
38Broad-based gait (HP:0002136)2.72559413
39Amblyopia (HP:0000646)2.70764982
40Dialeptic seizures (HP:0011146)2.68893561
41Acute encephalopathy (HP:0006846)2.67175405
42Abnormality of secondary sexual hair (HP:0009888)2.67105410
43Abnormality of the axillary hair (HP:0100134)2.67105410
44Cerebral inclusion bodies (HP:0100314)2.66977643
45True hermaphroditism (HP:0010459)2.66321434
46Pancreatic cysts (HP:0001737)2.65443920
47Morphological abnormality of the middle ear (HP:0008609)2.64211444
48Generalized tonic-clonic seizures (HP:0002069)2.56591670
49Lipid accumulation in hepatocytes (HP:0006561)2.52875384
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52825125
51Drooling (HP:0002307)2.52503475
52Excessive salivation (HP:0003781)2.52503475
53Abnormal pancreas size (HP:0012094)2.51950581
54Progressive cerebellar ataxia (HP:0002073)2.49945886
55Optic disc pallor (HP:0000543)2.49392804
56Parakeratosis (HP:0001036)2.47791201
57Febrile seizures (HP:0002373)2.46712638
58Progressive inability to walk (HP:0002505)2.36053650
59Type II lissencephaly (HP:0007260)2.34951759
60Abnormality of the renal medulla (HP:0100957)2.34896211
61Abnormal eating behavior (HP:0100738)2.34885506
62Diastasis recti (HP:0001540)2.34549243
63Abnormality of the labia minora (HP:0012880)2.32774417
64Abnormality of binocular vision (HP:0011514)2.32344596
65Diplopia (HP:0000651)2.32344596
66Congenital, generalized hypertrichosis (HP:0004540)2.31332081
67Supranuclear gaze palsy (HP:0000605)2.31094732
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29621268
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28282062
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28141178
71Chronic hepatic failure (HP:0100626)2.27780051
72Pallor (HP:0000980)2.27096267
73Congenital stationary night blindness (HP:0007642)2.23090861
74Esotropia (HP:0000565)2.21537334
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.21111704
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.21111704
77Concave nail (HP:0001598)2.20653236
78Hypothermia (HP:0002045)2.18251937
79Polyphagia (HP:0002591)2.17743339
80Aplasia cutis congenita (HP:0001057)2.17212893
81Fibular aplasia (HP:0002990)2.17164097
82Thickened helices (HP:0000391)2.16414024
83Rib fusion (HP:0000902)2.15310807
84Congenital primary aphakia (HP:0007707)2.14202910
85Sclerocornea (HP:0000647)2.12783266
86Maternal diabetes (HP:0009800)2.12584546
87Aplasia involving bones of the extremities (HP:0009825)2.12398899
88Aplasia involving bones of the upper limbs (HP:0009823)2.12398899
89Aplasia of the phalanges of the hand (HP:0009802)2.12398899
90Pachygyria (HP:0001302)2.11350617
91Medial flaring of the eyebrow (HP:0010747)2.10420289
92Anencephaly (HP:0002323)2.09360105
93Optic nerve hypoplasia (HP:0000609)2.09268693
94Visual hallucinations (HP:0002367)2.09033917
95Increased CSF lactate (HP:0002490)2.08275583
96Adrenal hypoplasia (HP:0000835)2.08087871
97Atelectasis (HP:0100750)2.07333279
98Abnormality of salivation (HP:0100755)2.07271105
99Gait imbalance (HP:0002141)2.06350028
100Glycosuria (HP:0003076)2.04865018
101Abnormality of urine glucose concentration (HP:0011016)2.04865018
102Nephrogenic diabetes insipidus (HP:0009806)2.02403928
103Abnormality of renal resorption (HP:0011038)2.02331530
104Abnormality of the middle phalanges of the toes (HP:0010183)2.02114038
105Lissencephaly (HP:0001339)2.00813913
106Symphalangism affecting the phalanges of the hand (HP:0009773)2.00466175
107Alacrima (HP:0000522)1.99022207
108Abnormality of renin-angiotensin system (HP:0000847)1.98882028
109Septo-optic dysplasia (HP:0100842)1.98424133
110Pendular nystagmus (HP:0012043)1.97913804
111Exotropia (HP:0000577)1.97880469
112Abnormality of the corticospinal tract (HP:0002492)1.93675614
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91280617
114Oligodactyly (hands) (HP:0001180)1.88945228
115Hyperphosphaturia (HP:0003109)1.88289642
116Sensory axonal neuropathy (HP:0003390)1.87902893
117Congenital malformation of the right heart (HP:0011723)1.87563671
118Double outlet right ventricle (HP:0001719)1.87563671
119Cerebral edema (HP:0002181)1.87311139
120Vaginal atresia (HP:0000148)1.87101627
121Leukodystrophy (HP:0002415)1.86864457
122Poor suck (HP:0002033)1.86266640
123Hepatocellular necrosis (HP:0001404)1.85999338
124Genital tract atresia (HP:0001827)1.84974125
125Metabolic alkalosis (HP:0200114)1.84955899
126Hypogonadotrophic hypogonadism (HP:0000044)1.84251324
127Sex reversal (HP:0012245)1.84089855
128Abnormal sex determination (HP:0012244)1.84089855
129Anophthalmia (HP:0000528)1.83739569
130Osteomalacia (HP:0002749)1.82902043
131Abnormality of macular pigmentation (HP:0008002)1.81223078
132Cupped ear (HP:0000378)1.80942356
133Confusion (HP:0001289)1.80616826
134Absent speech (HP:0001344)1.80218514
135X-linked dominant inheritance (HP:0001423)1.80166933
136Short tibia (HP:0005736)1.79395573
137Cystic liver disease (HP:0006706)1.78924154
138Neonatal hypoglycemia (HP:0001998)1.78848169
139Abnormal hair whorl (HP:0010721)1.78427101
140Hypoplastic left heart (HP:0004383)1.78059752
141Hypoplastic pelvis (HP:0008839)1.77590603
142Specific learning disability (HP:0001328)1.77358736
143Hepatic necrosis (HP:0002605)1.77116571
144Dysmetria (HP:0001310)1.76724142
145Abnormal urine phosphate concentration (HP:0012599)1.76088052
146Labial hypoplasia (HP:0000066)1.76037362
147Polydipsia (HP:0001959)1.75610460
148Abnormal drinking behavior (HP:0030082)1.75610460
149Choroideremia (HP:0001139)1.75405386
150Psychosis (HP:0000709)1.74248278
151Decreased lacrimation (HP:0000633)1.74091024
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.74064088
153Growth hormone deficiency (HP:0000824)1.73806774
154Rhinitis (HP:0012384)1.73477570
155Male pseudohermaphroditism (HP:0000037)1.73435296
156Anxiety (HP:0000739)1.73431617
157Absent septum pellucidum (HP:0001331)1.73345099
158Tubular atrophy (HP:0000092)1.71355064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.01899951
2CASK3.45740447
3NME13.35715557
4MARK13.13615700
5NTRK33.05168386
6EPHA42.80534698
7TLK12.49666322
8NTRK22.48990889
9TNIK2.48037601
10MAPK132.42122060
11MAP3K92.20935674
12RIPK42.07429297
13STK391.98632267
14STK161.84586354
15TYRO31.83613259
16CAMK2B1.77233216
17SIK21.76288113
18PINK11.69694049
19PKN11.61687212
20MAP2K71.60182174
21UHMK11.58122389
22DYRK21.57673006
23MAP3K121.57626990
24FGR1.52840127
25FES1.52303698
26OXSR11.50602867
27MAP3K41.47406599
28CAMK2A1.41626152
29GRK71.41246832
30DYRK31.36789288
31MUSK1.30054388
32LIMK11.26802419
33PHKG21.24233235
34PHKG11.24233235
35NUAK11.23156521
36CAMK2D1.21669361
37BMPR1B1.20251022
38PAK31.19703546
39CSNK1G31.16130196
40ROCK21.15900519
41MINK11.12859654
42MST41.11798828
43BMPR21.07671409
44GRK51.06105944
45CSNK1G21.06008904
46MYLK1.00161666
47CDK50.98250190
48RPS6KA20.97875200
49DYRK1B0.97210753
50PAK60.96448726
51DYRK1A0.94086426
52ACVR1B0.93454456
53BCR0.92934970
54SGK20.92005331
55EPHB20.89961220
56TAF10.89855066
57MAP3K110.89605517
58TNK20.88700638
59CAMK2G0.85731489
60KSR10.83615578
61ADRBK20.83300633
62PLK20.82795248
63CSNK1G10.82762993
64CAMK1G0.82587565
65PRKCE0.81461228
66MAP2K40.80766041
67PRKCG0.79237371
68CSNK1A1L0.76899394
69CDK190.76509739
70MAPKAPK50.76483747
71WNK40.76266265
72PIK3CA0.72839757
73MAPK150.72591065
74PRKG10.71850023
75YES10.71645343
76CDK30.71165597
77WNK30.69541942
78CAMK1D0.69506642
79TAOK10.68132828
80PRKACA0.67151582
81VRK10.66568716
82SGK10.66242527
83CDK140.65460987
84FGFR20.65435368
85DMPK0.65279646
86CLK10.65216320
87BCKDK0.64382618
88PASK0.63567720
89FRK0.63314151
90DAPK20.63154938
91CAMKK10.63076340
92CDK150.61464099
93ADRBK10.61016282
94PRKCI0.60803987
95RPS6KA60.60096897
96CDK180.59683473
97NEK60.58444910
98ABL20.58353628
99GRK60.57524768
100CDK11A0.56127178
101PRPF4B0.55545585
102PRKCQ0.54385037
103MAP3K100.54245976
104MARK20.53484277
105CDC70.51523307
106PRKACB0.50126071
107TGFBR10.49289754
108ROCK10.49283382
109NEK20.48673562
110FYN0.48048538
111MAP3K60.47515238
112INSRR0.47353959
113ZAK0.46731705
114PTK2B0.45871530
115CSNK1E0.45778048
116PRKCB0.44866682
117CSNK1A10.44696963
118CDC42BPA0.44333528
119MKNK20.43533579
120RPS6KC10.43250171
121RPS6KL10.43250171
122CAMK10.42556759
123ERBB20.42195803
124PRKCZ0.41961323
125MAP2K10.41558525
126MAPK120.41464760
127SGK4940.40694243
128SGK2230.40694243
129STK110.40498304
130PRKCA0.39931372
131PRKCH0.38993544
132GRK10.38973116
133MAPK40.36982822
134PRKACG0.36365842
135RAF10.36276732
136TAOK30.35850491
137SIK10.33869111
138DDR20.33209192
139STK240.32515177
140MAP2K20.32429504

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.45568434
2Oxidative phosphorylation_Homo sapiens_hsa001903.72544470
3Parkinsons disease_Homo sapiens_hsa050122.96039538
4Alzheimers disease_Homo sapiens_hsa050102.74850279
5Renin-angiotensin system_Homo sapiens_hsa046142.51858947
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50210909
7Asthma_Homo sapiens_hsa053102.49899350
8Cardiac muscle contraction_Homo sapiens_hsa042602.40015092
9Serotonergic synapse_Homo sapiens_hsa047262.25981767
10Glutamatergic synapse_Homo sapiens_hsa047242.23228468
11GABAergic synapse_Homo sapiens_hsa047272.20131025
12Huntingtons disease_Homo sapiens_hsa050162.15199472
13Taste transduction_Homo sapiens_hsa047422.15121934
14Morphine addiction_Homo sapiens_hsa050322.04906387
15Amphetamine addiction_Homo sapiens_hsa050311.88451076
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79014930
17Circadian entrainment_Homo sapiens_hsa047131.75493820
18Olfactory transduction_Homo sapiens_hsa047401.70783715
19Cocaine addiction_Homo sapiens_hsa050301.69154000
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69107964
21Axon guidance_Homo sapiens_hsa043601.65170589
22Renin secretion_Homo sapiens_hsa049241.64006080
23Salivary secretion_Homo sapiens_hsa049701.56782786
24Long-term potentiation_Homo sapiens_hsa047201.56182631
25Long-term depression_Homo sapiens_hsa047301.53930669
26Phototransduction_Homo sapiens_hsa047441.52592804
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49846016
28Dopaminergic synapse_Homo sapiens_hsa047281.48363628
29Sulfur relay system_Homo sapiens_hsa041221.43796539
30Calcium signaling pathway_Homo sapiens_hsa040201.38571512
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37235413
32Synaptic vesicle cycle_Homo sapiens_hsa047211.31640571
33Collecting duct acid secretion_Homo sapiens_hsa049661.28901241
34Ether lipid metabolism_Homo sapiens_hsa005651.28793647
35Basal cell carcinoma_Homo sapiens_hsa052171.26840364
36Tryptophan metabolism_Homo sapiens_hsa003801.25639362
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23413413
38Vitamin digestion and absorption_Homo sapiens_hsa049771.23397075
39Insulin secretion_Homo sapiens_hsa049111.20850565
40Gastric acid secretion_Homo sapiens_hsa049711.18942810
41Vibrio cholerae infection_Homo sapiens_hsa051101.16142167
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14953295
43Cholinergic synapse_Homo sapiens_hsa047251.10964978
44Pancreatic secretion_Homo sapiens_hsa049721.09267164
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06695524
46Oxytocin signaling pathway_Homo sapiens_hsa049211.06468518
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06050610
48Protein export_Homo sapiens_hsa030601.03491284
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02336692
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99518918
51Gap junction_Homo sapiens_hsa045400.98807936
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.98722136
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96984903
54Nitrogen metabolism_Homo sapiens_hsa009100.96902951
55Ribosome_Homo sapiens_hsa030100.95940827
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95405507
57RNA polymerase_Homo sapiens_hsa030200.89338551
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87988661
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85993650
60cAMP signaling pathway_Homo sapiens_hsa040240.83888745
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83520668
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83043128
63Arachidonic acid metabolism_Homo sapiens_hsa005900.82373718
64Linoleic acid metabolism_Homo sapiens_hsa005910.81608465
65Retinol metabolism_Homo sapiens_hsa008300.80005764
66GnRH signaling pathway_Homo sapiens_hsa049120.79330119
67Chemical carcinogenesis_Homo sapiens_hsa052040.78767706
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78219742
69Bile secretion_Homo sapiens_hsa049760.76955180
70Melanogenesis_Homo sapiens_hsa049160.75763052
71Dilated cardiomyopathy_Homo sapiens_hsa054140.71099326
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69945396
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69108049
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68445799
75Caffeine metabolism_Homo sapiens_hsa002320.67238878
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66846345
77Tyrosine metabolism_Homo sapiens_hsa003500.66752287
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.66515891
79Sulfur metabolism_Homo sapiens_hsa009200.65300883
80Basal transcription factors_Homo sapiens_hsa030220.65230370
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65170554
82Sphingolipid metabolism_Homo sapiens_hsa006000.64751519
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.64718559
84Ovarian steroidogenesis_Homo sapiens_hsa049130.64392427
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63284681
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62766424
87Type II diabetes mellitus_Homo sapiens_hsa049300.62257166
88Glycerolipid metabolism_Homo sapiens_hsa005610.60487699
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56016486
90African trypanosomiasis_Homo sapiens_hsa051430.55651768
91Hedgehog signaling pathway_Homo sapiens_hsa043400.55243656
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54945645
93Mineral absorption_Homo sapiens_hsa049780.54906922
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53728948
95Ras signaling pathway_Homo sapiens_hsa040140.51779214
96Peroxisome_Homo sapiens_hsa041460.51620464
97Phenylalanine metabolism_Homo sapiens_hsa003600.51059537
98Steroid biosynthesis_Homo sapiens_hsa001000.50718142
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50363330
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.48284758
101Prion diseases_Homo sapiens_hsa050200.47032924
102Choline metabolism in cancer_Homo sapiens_hsa052310.45171111
103Selenocompound metabolism_Homo sapiens_hsa004500.44456199
104Estrogen signaling pathway_Homo sapiens_hsa049150.43738038
105Wnt signaling pathway_Homo sapiens_hsa043100.43268451
106Regulation of autophagy_Homo sapiens_hsa041400.42830283
107Notch signaling pathway_Homo sapiens_hsa043300.42226258
108Metabolic pathways_Homo sapiens_hsa011000.42105391
109Alcoholism_Homo sapiens_hsa050340.40868521
110Hippo signaling pathway_Homo sapiens_hsa043900.40569558
111ErbB signaling pathway_Homo sapiens_hsa040120.40268206
112Thyroid hormone synthesis_Homo sapiens_hsa049180.37904437
113MAPK signaling pathway_Homo sapiens_hsa040100.37763090
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37371160
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37161408
116Fatty acid elongation_Homo sapiens_hsa000620.35893684
117Dorso-ventral axis formation_Homo sapiens_hsa043200.33757719
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31534981
119Rheumatoid arthritis_Homo sapiens_hsa053230.31371519
120Starch and sucrose metabolism_Homo sapiens_hsa005000.31313709
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30323877
122Fat digestion and absorption_Homo sapiens_hsa049750.29962839
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.29149631
124Histidine metabolism_Homo sapiens_hsa003400.28396842
125Protein digestion and absorption_Homo sapiens_hsa049740.28087074
126Butanoate metabolism_Homo sapiens_hsa006500.28040952
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.27335734
128Autoimmune thyroid disease_Homo sapiens_hsa053200.27212510
129Rap1 signaling pathway_Homo sapiens_hsa040150.25528990

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