TPSP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.39107828
2positive regulation of protein kinase C signaling (GO:0090037)7.19012426
3response to parathyroid hormone (GO:0071107)6.17214005
4melanin biosynthetic process (GO:0042438)5.68060012
5uterus development (GO:0060065)5.45438660
6negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)5.39531082
7melanin metabolic process (GO:0006582)5.09674248
8secondary metabolite biosynthetic process (GO:0044550)5.00737429
9positive regulation of cellular amine metabolic process (GO:0033240)4.86863789
10complement activation, alternative pathway (GO:0006957)4.58416128
11regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.46446857
12seminiferous tubule development (GO:0072520)4.40650782
13regulation of triglyceride catabolic process (GO:0010896)4.39700754
14cellular response to ATP (GO:0071318)4.11797217
15anatomical structure regression (GO:0060033)4.11512601
16L-phenylalanine metabolic process (GO:0006558)4.09290417
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.09290417
18negative regulation of metanephros development (GO:0072217)4.02328973
19atrioventricular valve morphogenesis (GO:0003181)3.92792509
20regulation of hydrogen peroxide metabolic process (GO:0010310)3.88950187
21negative regulation of cell size (GO:0045792)3.82272308
22response to acidic pH (GO:0010447)3.76125083
23negative regulation of kidney development (GO:0090185)3.75924148
24sex determination (GO:0007530)3.75648893
25epithelial cell fate commitment (GO:0072148)3.74568147
26cilium or flagellum-dependent cell motility (GO:0001539)3.70864797
27cardiac right ventricle morphogenesis (GO:0003215)3.69268252
28labyrinthine layer development (GO:0060711)3.65750510
29L-phenylalanine catabolic process (GO:0006559)3.64160361
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64160361
31positive regulation of triglyceride metabolic process (GO:0090208)3.62048135
32negative regulation of macrophage differentiation (GO:0045650)3.59839833
33sex differentiation (GO:0007548)3.59448932
34regulation of protein activation cascade (GO:2000257)3.55222547
35ear development (GO:0043583)3.54885223
36proline metabolic process (GO:0006560)3.54683412
37semaphorin-plexin signaling pathway (GO:0071526)3.53624093
38regulation of complement activation (GO:0030449)3.53215896
39regulation of protein kinase C signaling (GO:0090036)3.49778192
40proline biosynthetic process (GO:0006561)3.49066374
41regulation of gonadotropin secretion (GO:0032276)3.47088923
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.46961289
43endothelial cell morphogenesis (GO:0001886)3.45364573
44detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.43127736
45detection of temperature stimulus involved in sensory perception (GO:0050961)3.43127736
46positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.40830412
47regulation of bile acid biosynthetic process (GO:0070857)3.39985055
48cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.33264190
49positive regulation of synapse maturation (GO:0090129)3.31932179
50hindbrain development (GO:0030902)3.25049403
51positive regulation of receptor recycling (GO:0001921)3.24107851
52regulation of synapse maturation (GO:0090128)3.23702032
53cell-cell junction maintenance (GO:0045217)3.17993768
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14382366
55positive regulation of male gonad development (GO:2000020)3.12681343
56positive regulation of triglyceride biosynthetic process (GO:0010867)3.11839152
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08861390
58Golgi transport vesicle coating (GO:0048200)3.04546465
59COPI coating of Golgi vesicle (GO:0048205)3.04546465
60positive regulation of hormone metabolic process (GO:0032352)2.99896678
61regulation of cholesterol biosynthetic process (GO:0045540)2.99658263
62flavonoid metabolic process (GO:0009812)2.98262688
63regulation of cell proliferation involved in kidney development (GO:1901722)2.95923709
64vascular endothelial growth factor signaling pathway (GO:0038084)2.94714307
65heart valve morphogenesis (GO:0003179)2.91542924
66positive regulation of lipoprotein lipase activity (GO:0051006)2.90815434
67positive regulation of triglyceride lipase activity (GO:0061365)2.90815434
68regulation of triglyceride metabolic process (GO:0090207)2.90643049
69male sex determination (GO:0030238)2.87909871
70basement membrane organization (GO:0071711)2.86249675
71interferon-gamma secretion (GO:0072643)2.85525338
72mesenchymal to epithelial transition (GO:0060231)2.84926850
73regulation of ARF GTPase activity (GO:0032312)2.84233041
74regulation of cholesterol metabolic process (GO:0090181)2.83084104
75histone H4-K12 acetylation (GO:0043983)2.82982612
76regulation of cholesterol esterification (GO:0010872)2.78900553
77response to food (GO:0032094)2.78375751
78SMAD protein signal transduction (GO:0060395)2.77371076
79positive regulation of lipid catabolic process (GO:0050996)2.77216712
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.76485512
81exogenous drug catabolic process (GO:0042738)2.75339751
82phospholipid efflux (GO:0033700)2.75064697
83cellular response to gonadotropin stimulus (GO:0071371)2.72790107
84regulation of fatty acid beta-oxidation (GO:0031998)2.72059480
85embryonic camera-type eye development (GO:0031076)2.71060884
86urogenital system development (GO:0001655)2.71044249
87aromatic amino acid family catabolic process (GO:0009074)2.70327257
88negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.69233890
89desmosome organization (GO:0002934)2.68803896
90fusion of sperm to egg plasma membrane (GO:0007342)2.67265349
91positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.67206132
92facial nerve structural organization (GO:0021612)2.66981371
93regulation of plasminogen activation (GO:0010755)2.66920031
94glucose 6-phosphate metabolic process (GO:0051156)2.65891975
95phenol-containing compound biosynthetic process (GO:0046189)2.63707165
96neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.63431388
97drug catabolic process (GO:0042737)2.61441732
98response to water (GO:0009415)2.60401375
99regulation of receptor recycling (GO:0001919)2.59258217
100polarized epithelial cell differentiation (GO:0030859)2.59141497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.86581397
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.67674583
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.63148601
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.59314208
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.43385077
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.14116359
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09983734
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05759445
9ZNF263_19887448_ChIP-Seq_K562_Human3.03820671
10LXR_22292898_ChIP-Seq_THP-1_Human2.77431113
11RACK7_27058665_Chip-Seq_MCF-7_Human2.67252392
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.62996828
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45354894
14RUNX1_27514584_Chip-Seq_MCF-7_Human2.34650303
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.33461996
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33188270
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.31038698
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.16989071
19P68_20966046_ChIP-Seq_HELA_Human2.14010639
20ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.11661980
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.00086063
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97983498
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95466514
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93998543
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.91552425
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89977889
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88732521
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87789807
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.84475969
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78936157
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77547286
32CTCF_27219007_Chip-Seq_Bcells_Human1.75767407
33KDM2B_26808549_Chip-Seq_K562_Human1.70303323
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68475442
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65145060
36SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65139827
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62933505
38RARB_24833708_ChIP-Seq_LIVER_Mouse1.58896688
39BCOR_27268052_Chip-Seq_Bcells_Human1.58803907
40SMC4_20622854_ChIP-Seq_HELA_Human1.56887132
41DROSHA_22980978_ChIP-Seq_HELA_Human1.54960662
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51698744
43E2F1_20622854_ChIP-Seq_HELA_Human1.51673338
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50726251
45TCF7_22412390_ChIP-Seq_EML_Mouse1.49457711
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.40230227
47CREB1_26743006_Chip-Seq_LNCaP_Human1.39695226
48BCL6_27268052_Chip-Seq_Bcells_Human1.39511645
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38241214
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38021151
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37594880
52KDM2B_26808549_Chip-Seq_DND41_Human1.36643475
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36275911
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35672029
55PHF8_20622854_ChIP-Seq_HELA_Human1.32447788
56RARA_24833708_ChIP-Seq_LIVER_Mouse1.30425774
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24985271
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.20162967
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19748357
60TP63_22573176_ChIP-Seq_HFKS_Human1.18644771
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.18286873
62VDR_21846776_ChIP-Seq_THP-1_Human1.17098720
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14901521
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.13553322
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13544064
66CTCF_20526341_ChIP-Seq_ESCs_Human1.11836273
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.09885053
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07784404
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07369351
70ATF3_27146783_Chip-Seq_COLON_Human1.05933870
71AHR_22903824_ChIP-Seq_MCF-7_Human1.05904908
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.05533984
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04708812
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.03642064
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.03286090
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02997384
77CTCF_21964334_Chip-Seq_Bcells_Human1.02913665
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02897211
79ERA_21632823_ChIP-Seq_H3396_Human1.02481856
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00299354
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99661027
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99521752
83KLF5_25053715_ChIP-Seq_YYC3_Human0.98849114
84SA1_27219007_Chip-Seq_Bcells_Human0.98287129
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98276203
86NCOR1_26117541_ChIP-Seq_K562_Human0.97621699
87GATA6_25053715_ChIP-Seq_YYC3_Human0.97367946
88CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97146170
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96961349
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95156417
91TP53_22127205_ChIP-Seq_IMR90_Human0.94960114
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93960426
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93805938
94FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92561261
95SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92499555
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92469711
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92275124
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91500563
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91446584
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91059131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting7.07418545
2MP0003315_abnormal_perineum_morphology4.01711369
3MP0003136_yellow_coat_color3.85126912
4MP0004381_abnormal_hair_follicle3.51397696
5MP0005409_darkened_coat_color3.20626533
6MP0005058_abnormal_lysosome_morphology3.14055444
7MP0000678_abnormal_parathyroid_gland3.11290975
8MP0001986_abnormal_taste_sensitivity2.79020950
9MP0008995_early_reproductive_senescence2.70114806
10MP0000537_abnormal_urethra_morphology2.58345682
11MP0002249_abnormal_larynx_morphology2.50715623
12MP0008872_abnormal_physiological_respon2.33614336
13MP0000013_abnormal_adipose_tissue2.32057574
14MP0001666_abnormal_nutrient_absorption2.29818413
15MP0001661_extended_life_span2.19584412
16MP0006292_abnormal_olfactory_placode2.15655420
17MP0009840_abnormal_foam_cell2.07032163
18MP0002089_abnormal_postnatal_growth/wei2.01565246
19MP0009384_cardiac_valve_regurgitation1.96529071
20MP0003121_genomic_imprinting1.93197987
21MP0005360_urolithiasis1.92879573
22MP0001188_hyperpigmentation1.92338552
23MP0002234_abnormal_pharynx_morphology1.87875616
24MP0005365_abnormal_bile_salt1.81258547
25MP0005503_abnormal_tendon_morphology1.80663957
26MP0003119_abnormal_digestive_system1.77812219
27MP0001968_abnormal_touch/_nociception1.75971282
28MP0000467_abnormal_esophagus_morphology1.74491184
29MP0009672_abnormal_birth_weight1.69691380
30MP0008875_abnormal_xenobiotic_pharmacok1.53131767
31MP0003868_abnormal_feces_composition1.51055233
32MP0003172_abnormal_lysosome_physiology1.45991536
33MP0010368_abnormal_lymphatic_system1.38915016
34MP0002796_impaired_skin_barrier1.37949331
35MP0005367_renal/urinary_system_phenotyp1.34826362
36MP0000516_abnormal_urinary_system1.34826362
37MP0002098_abnormal_vibrissa_morphology1.32484170
38MP0002282_abnormal_trachea_morphology1.29628853
39MP0005083_abnormal_biliary_tract1.28295486
40MP0004133_heterotaxia1.27532902
41MP0010329_abnormal_lipoprotein_level1.27056488
42MP0006138_congestive_heart_failure1.26160100
43MP0002139_abnormal_hepatobiliary_system1.25746285
44MP0001849_ear_inflammation1.21583650
45MP0002735_abnormal_chemical_nociception1.21561489
46MP0005670_abnormal_white_adipose1.17684187
47MP0005187_abnormal_penis_morphology1.17241383
48MP0005085_abnormal_gallbladder_physiolo1.16662582
49MP0000427_abnormal_hair_cycle1.15834063
50MP0005076_abnormal_cell_differentiation1.11211791
51MP0003936_abnormal_reproductive_system1.10630295
52MP0003942_abnormal_urinary_system1.09553932
53MP0003866_abnormal_defecation1.09451883
54MP0003115_abnormal_respiratory_system1.07575135
55MP0004043_abnormal_pH_regulation1.01429201
56MP0001919_abnormal_reproductive_system0.99550753
57MP0000003_abnormal_adipose_tissue0.99469314
58MP0009643_abnormal_urine_homeostasis0.96544717
59MP0000371_diluted_coat_color0.95953351
60MP0000639_abnormal_adrenal_gland0.95800013
61MP0004264_abnormal_extraembryonic_tissu0.93482300
62MP0004510_myositis0.92766994
63MP0000383_abnormal_hair_follicle0.92451687
64MP0000767_abnormal_smooth_muscle0.91372468
65MP0003195_calcinosis0.90935735
66MP0001664_abnormal_digestion0.89875663
67MP0002970_abnormal_white_adipose0.84754188
68MP0005375_adipose_tissue_phenotype0.83906563
69MP0002822_catalepsy0.83613661
70MP0002932_abnormal_joint_morphology0.83259864
71MP0005220_abnormal_exocrine_pancreas0.81196257
72MP0000538_abnormal_urinary_bladder0.79779572
73MP0000470_abnormal_stomach_morphology0.79713777
74MP0003705_abnormal_hypodermis_morpholog0.78693645
75MP0002933_joint_inflammation0.78618018
76MP0005508_abnormal_skeleton_morphology0.77915458
77MP0005377_hearing/vestibular/ear_phenot0.77589704
78MP0003878_abnormal_ear_physiology0.77589704
79MP0001727_abnormal_embryo_implantation0.75137606
80MP0005666_abnormal_adipose_tissue0.72796425
81MP0009931_abnormal_skin_appearance0.71195388
82MP0009703_decreased_birth_body0.70931463
83MP0005595_abnormal_vascular_smooth0.68299428
84MP0005165_increased_susceptibility_to0.67903781
85MP0003638_abnormal_response/metabolism_0.67339995
86MP0002132_abnormal_respiratory_system0.66892077
87MP0000751_myopathy0.65688763
88MP0002653_abnormal_ependyma_morphology0.64280929
89MP0008775_abnormal_heart_ventricle0.63115305
90MP0000609_abnormal_liver_physiology0.62853387
91MP0002135_abnormal_kidney_morphology0.62810046
92MP0003453_abnormal_keratinocyte_physiol0.62519575
93MP0005389_reproductive_system_phenotype0.62419497
94MP0000681_abnormal_thyroid_gland0.60263103
95MP0003786_premature_aging0.58694401
96MP0001873_stomach_inflammation0.57978624
97MP0001502_abnormal_circadian_rhythm0.57730698
98MP0002118_abnormal_lipid_homeostasis0.56800485
99MP0001765_abnormal_ion_homeostasis0.56614816
100MP0005501_abnormal_skin_physiology0.56230095

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)8.02925190
2Male infertility (HP:0003251)5.26183105
3Lymphangioma (HP:0100764)5.05250088
4Chronic otitis media (HP:0000389)4.41328688
5Testicular atrophy (HP:0000029)4.25842659
6Deformed sella turcica (HP:0002681)4.03191917
7Mucopolysacchariduria (HP:0008155)3.94644449
8Urinary glycosaminoglycan excretion (HP:0003541)3.94644449
9Cervical subluxation (HP:0003308)3.85769000
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.82634207
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.76854539
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.76854539
13Abnormality of polysaccharide metabolism (HP:0011012)3.76854539
14Enlarged penis (HP:0000040)3.73621229
15Nuclear cataract (HP:0100018)3.68598910
16Clumsiness (HP:0002312)3.49705581
17Biconcave vertebral bodies (HP:0004586)3.43436510
18Vitreoretinal degeneration (HP:0000655)3.36102647
19Increased cerebral lipofuscin (HP:0011813)3.20936428
20Dysostosis multiplex (HP:0000943)3.19380292
21Gout (HP:0001997)3.17018242
22Ulnar bowing (HP:0003031)3.14040067
23Deep venous thrombosis (HP:0002625)3.09517344
24Chronic sinusitis (HP:0011109)3.02283061
25Abnormality of the sella turcica (HP:0002679)2.93154307
26Distal lower limb muscle weakness (HP:0009053)2.84915654
27Sex reversal (HP:0012245)2.72313282
28Abnormal sex determination (HP:0012244)2.72313282
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71807732
30Hypoplasia of the odontoid process (HP:0003311)2.71027304
31Neurodegeneration (HP:0002180)2.70354314
32Thin bony cortex (HP:0002753)2.69345330
33Glomerulonephritis (HP:0000099)2.68497145
34Abnormal respiratory motile cilium morphology (HP:0005938)2.68274971
35Abnormal respiratory epithelium morphology (HP:0012253)2.68274971
36Upper limb amyotrophy (HP:0009129)2.65646817
37Distal upper limb amyotrophy (HP:0007149)2.65646817
38Stridor (HP:0010307)2.61309303
39Infantile muscular hypotonia (HP:0008947)2.59778028
40Macroorchidism (HP:0000053)2.59302065
41Hemorrhage of the eye (HP:0011885)2.57969514
42Easy fatigability (HP:0003388)2.56667346
43Severe Myopia (HP:0011003)2.54350664
44Broad face (HP:0000283)2.52005860
45Protruding tongue (HP:0010808)2.51406829
46Depressed nasal tip (HP:0000437)2.43537421
47Mitral stenosis (HP:0001718)2.42890987
48Diaphragmatic weakness (HP:0009113)2.42403613
49Ependymoma (HP:0002888)2.42162280
50Nonimmune hydrops fetalis (HP:0001790)2.35533159
51Neonatal onset (HP:0003623)2.31758669
52Testicular neoplasm (HP:0010788)2.31301742
53Pigmentary retinal degeneration (HP:0001146)2.30474317
54Reticulocytosis (HP:0001923)2.27950718
55Male pseudohermaphroditism (HP:0000037)2.26718021
56Prolonged partial thromboplastin time (HP:0003645)2.25768220
57Cerebral aneurysm (HP:0004944)2.25234003
58Concave nail (HP:0001598)2.22679191
59Abnormality of male internal genitalia (HP:0000022)2.22341906
60Abnormality of the acetabulum (HP:0003170)2.20814835
61Neoplasm of the heart (HP:0100544)2.18318394
62Joint stiffness (HP:0001387)2.18045008
63Abnormality of the odontoid process (HP:0003310)2.17547782
64Flat acetabular roof (HP:0003180)2.17020250
65Obstructive sleep apnea (HP:0002870)2.13488407
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12708789
67Protrusio acetabuli (HP:0003179)2.08829254
68Esophageal varix (HP:0002040)2.08197480
69Right ventricular cardiomyopathy (HP:0011663)2.08021329
70Bulbar palsy (HP:0001283)2.07769861
71Renal salt wasting (HP:0000127)2.07529335
72Complement deficiency (HP:0004431)2.04044109
73Abnormality of the thoracic spine (HP:0100711)2.04009628
74Visceral angiomatosis (HP:0100761)2.03932588
75Retinal atrophy (HP:0001105)1.99791880
76Cerebral palsy (HP:0100021)1.97185716
77Hypophosphatemia (HP:0002148)1.97034640
78Metaphyseal cupping (HP:0003021)1.96700547
79Coxa valga (HP:0002673)1.94006450
80Mildly elevated creatine phosphokinase (HP:0008180)1.92554889
81Spinal canal stenosis (HP:0003416)1.89836913
82Beaking of vertebral bodies (HP:0004568)1.87416355
83Tracheal stenosis (HP:0002777)1.87286906
84Hand muscle atrophy (HP:0009130)1.87082135
85Septate vagina (HP:0001153)1.85747888
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84152481
87Gonadal dysgenesis (HP:0000133)1.82725663
88Akinesia (HP:0002304)1.79148668
89Aortic regurgitation (HP:0001659)1.76136397
90Myopathic facies (HP:0002058)1.75269306
91Thoracic kyphosis (HP:0002942)1.71575778
92Hemangiomatosis (HP:0007461)1.70038649
93Curly hair (HP:0002212)1.66633213
94Opisthotonus (HP:0002179)1.66590018
95Generalized hypopigmentation of hair (HP:0011358)1.66310265
96Lymphedema (HP:0001004)1.66120925
97Bowed forearm bones (HP:0003956)1.65658856
98Bowing of the arm (HP:0006488)1.65658856
99Wrist flexion contracture (HP:0001239)1.65046777
100Pterygium (HP:0001059)1.63778643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.44453200
2MUSK4.81158399
3TRIB34.34009858
4EPHA23.03090204
5MST1R2.98841462
6CASK2.96260794
7KDR2.86495964
8NME12.67442543
9WNK42.65356098
10INSRR2.49530237
11ICK2.38196278
12PKN22.37941088
13PTK62.33290900
14ERN12.22103858
15NTRK32.16913496
16EPHB12.13851364
17GRK61.99265602
18MAP2K61.94368287
19MAPKAPK31.91250687
20RIPK11.86899978
21MAP3K131.77778014
22RPS6KA21.67515069
23MAP3K61.62546669
24MAP2K21.47607395
25RPS6KB21.40448428
26NME21.30646879
27RPS6KC11.28479140
28RPS6KL11.28479140
29PRKD21.27712992
30MET1.21662991
31RPS6KA61.18501215
32PTK21.18071142
33MAP3K71.16332479
34CHUK1.16174241
35HIPK21.07359693
36PRKCI0.93121356
37TNK20.90104474
38TBK10.88570879
39IRAK30.87536362
40PDGFRA0.81960267
41PDPK10.81324638
42FER0.80624981
43DAPK20.79745053
44CDK70.78548084
45SMG10.76175092
46SIK30.73510455
47MARK20.73289036
48ERBB20.72839616
49TESK10.65428732
50MTOR0.64003599
51MAPK150.64001310
52RIPK40.60526676
53PRKD10.60340598
54BMX0.60339929
55MAP3K110.57922449
56SIK20.57020636
57PHKG20.54796402
58PHKG10.54796402
59RET0.53553495
60DYRK30.49305106
61IKBKB0.47330285
62MAPK70.46989980
63MAP4K10.46266311
64FGFR40.46101433
65DAPK10.45556340
66CAMK2B0.44041900
67TLK10.42260263
68RPS6KA10.42038803
69MAPK80.41163790
70MAP2K10.40753800
71LATS20.40003162
72PRKG20.39640872
73STK380.39610991
74PLK40.39384997
75WNK10.39222485
76PDK10.36128061
77PRKAA20.35923520
78IKBKE0.33605762
79RPS6KB10.33392006
80CAMK2G0.33272027
81MELK0.33071406
82PAK40.32074460
83LRRK20.31344203
84PRKCZ0.29928725
85NTRK10.29415196
86DYRK1B0.29205993
87MAP3K10.28847830
88TAOK20.27980231
89MAPK30.27685158
90CDK120.27160629
91ZAP700.26946589
92MAPKAPK20.26721059
93SRC0.26373961
94CSF1R0.26141749
95PDGFRB0.25190528
96SGK30.24966069
97MAPK10.24613024
98PRKAA10.24406234
99MAP2K30.23874963
100RPS6KA40.22872813

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.31315045
2Sulfur relay system_Homo sapiens_hsa041223.13858022
3Other glycan degradation_Homo sapiens_hsa005113.05684244
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05276366
5Complement and coagulation cascades_Homo sapiens_hsa046102.69054839
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.62057713
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.38951235
8Arginine biosynthesis_Homo sapiens_hsa002202.18815666
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.13711883
10Notch signaling pathway_Homo sapiens_hsa043302.13047899
11Caffeine metabolism_Homo sapiens_hsa002322.08766226
12Chemical carcinogenesis_Homo sapiens_hsa052041.93442657
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.92473335
14Phenylalanine metabolism_Homo sapiens_hsa003601.88784962
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85985958
16ABC transporters_Homo sapiens_hsa020101.83083545
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80987468
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63310442
19Ovarian steroidogenesis_Homo sapiens_hsa049131.57647535
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55795037
21Starch and sucrose metabolism_Homo sapiens_hsa005001.53189770
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51384504
23Bile secretion_Homo sapiens_hsa049761.48200777
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47644401
25Retinol metabolism_Homo sapiens_hsa008301.46584316
26Linoleic acid metabolism_Homo sapiens_hsa005911.40511485
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.38889372
28Fatty acid elongation_Homo sapiens_hsa000621.34011921
29Prion diseases_Homo sapiens_hsa050201.33928733
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.33419511
31Lysosome_Homo sapiens_hsa041421.28262600
32Fructose and mannose metabolism_Homo sapiens_hsa000511.27955012
33Insulin resistance_Homo sapiens_hsa049311.24336126
34TGF-beta signaling pathway_Homo sapiens_hsa043501.23827761
35AMPK signaling pathway_Homo sapiens_hsa041521.23710801
36Sulfur metabolism_Homo sapiens_hsa009201.19765164
37Histidine metabolism_Homo sapiens_hsa003401.17380082
38Lysine degradation_Homo sapiens_hsa003101.16212590
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14545314
40Tyrosine metabolism_Homo sapiens_hsa003501.10597449
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10154652
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.03702319
43Insulin signaling pathway_Homo sapiens_hsa049101.03333379
44mTOR signaling pathway_Homo sapiens_hsa041501.02313934
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01631094
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01036941
47Arginine and proline metabolism_Homo sapiens_hsa003300.96250562
48VEGF signaling pathway_Homo sapiens_hsa043700.95144294
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94488966
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90928693
51PPAR signaling pathway_Homo sapiens_hsa033200.86861565
52Vitamin digestion and absorption_Homo sapiens_hsa049770.82736556
53N-Glycan biosynthesis_Homo sapiens_hsa005100.80673613
54Biosynthesis of amino acids_Homo sapiens_hsa012300.79238519
55Fat digestion and absorption_Homo sapiens_hsa049750.78094775
56Fatty acid metabolism_Homo sapiens_hsa012120.77961875
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.76898528
58Axon guidance_Homo sapiens_hsa043600.70768135
59Galactose metabolism_Homo sapiens_hsa000520.70487424
60Arachidonic acid metabolism_Homo sapiens_hsa005900.69368582
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67895272
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64674212
63ECM-receptor interaction_Homo sapiens_hsa045120.62439900
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59651753
65Estrogen signaling pathway_Homo sapiens_hsa049150.59596066
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58941780
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58933465
68Melanogenesis_Homo sapiens_hsa049160.56878984
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56516226
70Acute myeloid leukemia_Homo sapiens_hsa052210.56069327
71Glucagon signaling pathway_Homo sapiens_hsa049220.55175052
72Fatty acid biosynthesis_Homo sapiens_hsa000610.53124137
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51551202
74Fatty acid degradation_Homo sapiens_hsa000710.50820509
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50246992
76Glutathione metabolism_Homo sapiens_hsa004800.48410423
77Folate biosynthesis_Homo sapiens_hsa007900.46355021
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45969262
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45835914
80Sphingolipid metabolism_Homo sapiens_hsa006000.43695323
81Choline metabolism in cancer_Homo sapiens_hsa052310.43364475
82Hepatitis C_Homo sapiens_hsa051600.42214597
83Thyroid hormone synthesis_Homo sapiens_hsa049180.41959348
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.39836745
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39504767
86Amoebiasis_Homo sapiens_hsa051460.38659626
87Chronic myeloid leukemia_Homo sapiens_hsa052200.37539642
88Prolactin signaling pathway_Homo sapiens_hsa049170.36160732
89Prostate cancer_Homo sapiens_hsa052150.33516406
90Tight junction_Homo sapiens_hsa045300.33441492
91beta-Alanine metabolism_Homo sapiens_hsa004100.32515416
92Taste transduction_Homo sapiens_hsa047420.32356472
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31855127
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.31616991
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31583679
96Metabolic pathways_Homo sapiens_hsa011000.30128162
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29605089
98Focal adhesion_Homo sapiens_hsa045100.27727300
99Ether lipid metabolism_Homo sapiens_hsa005650.26516587
100RNA polymerase_Homo sapiens_hsa030200.26270440

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