TPST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.88825781
2axon ensheathment in central nervous system (GO:0032291)7.88825781
3fatty acid elongation (GO:0030497)5.54188933
4fusion of sperm to egg plasma membrane (GO:0007342)5.28294450
5peptidyl-tyrosine autophosphorylation (GO:0038083)5.24364020
6ensheathment of neurons (GO:0007272)5.18718978
7axon ensheathment (GO:0008366)5.18718978
8myelination (GO:0042552)5.14979259
9myelin maintenance (GO:0043217)4.68980296
10adhesion of symbiont to host (GO:0044406)4.35080514
11virion attachment to host cell (GO:0019062)4.33531648
12adhesion of symbiont to host cell (GO:0044650)4.33531648
13astrocyte development (GO:0014002)4.20069328
14establishment of mitochondrion localization (GO:0051654)4.11362571
15plasma membrane fusion (GO:0045026)4.07490009
16cell adhesion mediated by integrin (GO:0033627)4.03520466
17glomerular filtration (GO:0003094)3.93563017
18pyrimidine nucleobase catabolic process (GO:0006208)3.80770280
19acrosome reaction (GO:0007340)3.69800637
20sperm motility (GO:0030317)3.65175029
21positive regulation of oligodendrocyte differentiation (GO:0048714)3.62723452
22negative regulation of neurotransmitter secretion (GO:0046929)3.60531139
23peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.58454307
24hemidesmosome assembly (GO:0031581)3.56085650
25oligodendrocyte differentiation (GO:0048709)3.53875201
26response to lipoprotein particle (GO:0055094)3.53167721
27long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.52091655
28synaptonemal complex assembly (GO:0007130)3.45334874
29sperm-egg recognition (GO:0035036)3.44161498
30nerve growth factor signaling pathway (GO:0038180)3.43315020
31male meiosis (GO:0007140)3.41934716
32postsynaptic membrane organization (GO:0001941)3.40665337
33gamma-aminobutyric acid transport (GO:0015812)3.29183524
34synaptonemal complex organization (GO:0070193)3.28904609
35interleukin-6-mediated signaling pathway (GO:0070102)3.27935629
36positive regulation of macrophage cytokine production (GO:0060907)3.27556965
37presynaptic membrane assembly (GO:0097105)3.26721032
38creatine metabolic process (GO:0006600)3.24398412
39detection of temperature stimulus involved in sensory perception (GO:0050961)3.23421645
40detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.23421645
41craniofacial suture morphogenesis (GO:0097094)3.19435497
42apical protein localization (GO:0045176)3.19054234
43protein heterotrimerization (GO:0070208)3.18034705
44piRNA metabolic process (GO:0034587)3.17586081
45renal filtration (GO:0097205)3.17038166
46bone trabecula formation (GO:0060346)3.15259860
47dermatan sulfate biosynthetic process (GO:0030208)3.14992739
48mating behavior (GO:0007617)3.11977789
49binding of sperm to zona pellucida (GO:0007339)3.10684932
50regulation of cilium movement (GO:0003352)3.10674011
51neuron cell-cell adhesion (GO:0007158)3.09283840
52Rap protein signal transduction (GO:0032486)3.09229697
53short-term memory (GO:0007614)3.08761991
54L-serine transport (GO:0015825)3.05850238
55presynaptic membrane organization (GO:0097090)3.04528780
56type B pancreatic cell proliferation (GO:0044342)3.02388862
57cholesterol biosynthetic process (GO:0006695)3.02319350
58response to methylmercury (GO:0051597)3.01602218
59fatty-acyl-CoA biosynthetic process (GO:0046949)3.00341705
60multicellular organism reproduction (GO:0032504)2.99649137
61negative regulation of neurotransmitter transport (GO:0051589)2.97179205
62reproduction (GO:0000003)2.97018891
63cranial suture morphogenesis (GO:0060363)2.88360855
64endodermal cell differentiation (GO:0035987)2.88334963
65sexual reproduction (GO:0019953)2.87813029
66spermatid development (GO:0007286)2.87438706
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86771578
68L-phenylalanine catabolic process (GO:0006559)2.86771578
69cell wall macromolecule catabolic process (GO:0016998)2.86388962
70cell wall macromolecule metabolic process (GO:0044036)2.86388962
71cell-cell recognition (GO:0009988)2.86270295
72negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.85356991
73calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85037106
74protein polyglutamylation (GO:0018095)2.84336760
75extracellular fibril organization (GO:0043206)2.84019735
76dermatan sulfate metabolic process (GO:0030205)2.83745543
77regulation of collateral sprouting (GO:0048670)2.82995971
78negative regulation of glucose import (GO:0046325)2.78543525
79detection of light stimulus involved in sensory perception (GO:0050962)2.78311607
80detection of light stimulus involved in visual perception (GO:0050908)2.78311607
81long-chain fatty acid biosynthetic process (GO:0042759)2.77949312
82mitochondrion transport along microtubule (GO:0047497)2.77558916
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77558916
84sterol biosynthetic process (GO:0016126)2.77076739
85protein retention in ER lumen (GO:0006621)2.76862380
86peptidyl-cysteine modification (GO:0018198)2.76334624
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75493408
88protein localization to synapse (GO:0035418)2.73810284
89axonal fasciculation (GO:0007413)2.72540296
90chaperone-mediated protein complex assembly (GO:0051131)2.72193400
91negative regulation of leukocyte chemotaxis (GO:0002689)2.71541570
92nucleobase catabolic process (GO:0046113)2.70633694
93protein localization to endosome (GO:0036010)2.70376910
94L-serine metabolic process (GO:0006563)2.70330478
95positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.68608852
96regulation of gene silencing by RNA (GO:0060966)2.68233059
97regulation of posttranscriptional gene silencing (GO:0060147)2.68233059
98regulation of gene silencing by miRNA (GO:0060964)2.68233059
99long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.67892621
100cellular response to leptin stimulus (GO:0044320)2.67747601
101glial cell development (GO:0021782)2.67671546
102ganglion development (GO:0061548)2.66603449
103low-density lipoprotein particle clearance (GO:0034383)2.66432504
104dopamine biosynthetic process (GO:0042416)2.65972909
105axon extension (GO:0048675)2.64036298
106cellular response to ATP (GO:0071318)2.63466051
107complement activation, classical pathway (GO:0006958)2.62822101
108collagen fibril organization (GO:0030199)2.62544796
109neuroblast proliferation (GO:0007405)2.62461820
110response to lead ion (GO:0010288)2.62056365
111cellular response to monoamine stimulus (GO:0071868)2.61164549
112cellular response to catecholamine stimulus (GO:0071870)2.61164549
113substantia nigra development (GO:0021762)2.61097741
114plasma lipoprotein particle clearance (GO:0034381)2.60375790
115maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60351652
116regulation of microtubule-based movement (GO:0060632)2.59907294
117acrosome assembly (GO:0001675)2.57925900
118detection of temperature stimulus (GO:0016048)2.57603514
119positive regulation of mitochondrial fission (GO:0090141)2.57448402
120asymmetric protein localization (GO:0008105)2.57121648
121axon extension involved in axon guidance (GO:0048846)2.56694974
122neuron projection extension involved in neuron projection guidance (GO:1902284)2.56694974
123dopamine transport (GO:0015872)2.56464089
124cilium or flagellum-dependent cell motility (GO:0001539)2.55965983
125COPI coating of Golgi vesicle (GO:0048205)2.55860901
126Golgi transport vesicle coating (GO:0048200)2.55860901
127auditory behavior (GO:0031223)2.54114107
128sperm capacitation (GO:0048240)2.53293434
129very long-chain fatty acid metabolic process (GO:0000038)2.52733559
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.52694581
131positive regulation of synapse assembly (GO:0051965)2.52686730
132myelination in peripheral nervous system (GO:0022011)2.51401900
133peripheral nervous system axon ensheathment (GO:0032292)2.51401900
134axon development (GO:0061564)2.50558952
135serine transport (GO:0032329)2.50443095
136venous blood vessel morphogenesis (GO:0048845)2.50231536
137keratan sulfate catabolic process (GO:0042340)2.49531819
138substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48735674
139substrate-independent telencephalic tangential migration (GO:0021826)2.48735674
140neuron recognition (GO:0008038)2.46121468
141neuronal ion channel clustering (GO:0045161)2.44867842
142neurotransmitter-gated ion channel clustering (GO:0072578)2.43606243
143glutamate secretion (GO:0014047)2.42243184
144response to dietary excess (GO:0002021)2.41177855
145synapse assembly (GO:0007416)2.39971743
146chondroitin sulfate catabolic process (GO:0030207)2.39513736
147negative chemotaxis (GO:0050919)2.38715856
148heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38147374
149neuron projection extension (GO:1990138)2.36632993
150homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.36116681
151negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35538003
152synaptic vesicle exocytosis (GO:0016079)2.35472224
153skin morphogenesis (GO:0043589)2.35061016
154protein localization to cilium (GO:0061512)2.34979641
155cellular copper ion homeostasis (GO:0006878)2.34535588
156synaptic vesicle endocytosis (GO:0048488)2.34117402
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33263139
158regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31874456
159nonmotile primary cilium assembly (GO:0035058)2.30875788
160chondrocyte proliferation (GO:0035988)2.29337193
161lung vasculature development (GO:0060426)2.28117064
162sequestering of extracellular ligand from receptor (GO:0035581)2.25431430
163substrate-dependent cell migration (GO:0006929)2.25155200
164vocalization behavior (GO:0071625)2.25005841
165positive regulation of axon extension (GO:0045773)2.23038689
166heparan sulfate proteoglycan metabolic process (GO:0030201)2.20648666
167neurotransmitter biosynthetic process (GO:0042136)2.20379590
168neuronal action potential propagation (GO:0019227)2.20294020
169C4-dicarboxylate transport (GO:0015740)2.18762339
170protein insertion into membrane (GO:0051205)2.18308621
171establishment of melanosome localization (GO:0032401)2.17422885
172transferrin transport (GO:0033572)2.16597797
173amino acid import (GO:0043090)2.16019461
174mesenchymal-epithelial cell signaling (GO:0060638)2.14336635
175establishment of vesicle localization (GO:0051650)2.13713969
176cerebral cortex cell migration (GO:0021795)2.12064921
177response to leptin (GO:0044321)2.11953996
178regulation of synapse assembly (GO:0051963)2.10704774
179membrane assembly (GO:0071709)2.10675644
180interleukin-1-mediated signaling pathway (GO:0070498)2.09577499
181melanosome transport (GO:0032402)2.09552281
182establishment of pigment granule localization (GO:0051905)2.09388578
183negative regulation of axon guidance (GO:1902668)2.08790820
184endoplasmic reticulum organization (GO:0007029)2.07541799
185glycosphingolipid biosynthetic process (GO:0006688)2.07480942
186collagen metabolic process (GO:0032963)2.06668880
187pyrimidine dimer repair (GO:0006290)2.06665552
188wound healing, spreading of epidermal cells (GO:0035313)2.05616680
189layer formation in cerebral cortex (GO:0021819)2.05610109
190regulation of axon guidance (GO:1902667)2.04933137
191extracellular matrix assembly (GO:0085029)2.03574207
192prepulse inhibition (GO:0060134)2.02573422
193collagen catabolic process (GO:0030574)2.02548038
194extracellular matrix disassembly (GO:0022617)2.01967056
195growth hormone secretion (GO:0030252)2.01677951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.91488271
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.71487419
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.42693548
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82857539
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70069770
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55633621
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.51173593
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24736244
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23063502
10TAF15_26573619_Chip-Seq_HEK293_Human2.17719365
11IGF1R_20145208_ChIP-Seq_DFB_Human2.05605675
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93095082
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90530417
14TP53_18474530_ChIP-ChIP_U2OS_Human1.82627655
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82260710
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.80882523
17ZNF274_21170338_ChIP-Seq_K562_Hela1.80710210
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78619436
19GBX2_23144817_ChIP-Seq_PC3_Human1.75949222
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75782488
21* IRF8_21731497_ChIP-ChIP_J774_Mouse1.73470538
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72140393
23SMAD4_21799915_ChIP-Seq_A2780_Human1.72054582
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71723044
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71060160
26CJUN_26792858_Chip-Seq_BT549_Human1.69674524
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.68983700
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68264087
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67676050
30* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62524199
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.62186857
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.58388339
33SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.58298306
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50676819
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50287388
36P300_19829295_ChIP-Seq_ESCs_Human1.49676035
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47802899
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47672855
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.46702268
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45970929
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43821799
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43774385
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43774385
44* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43347537
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.43158879
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.42802087
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42189507
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41820158
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41504274
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41280837
51BRD4_25478319_ChIP-Seq_HGPS_Human1.40377215
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39948738
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.39849824
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.38391333
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38097326
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36902016
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35933473
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.35905422
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34101535
60* KLF4_19829295_ChIP-Seq_ESCs_Human1.32911557
61TP53_16413492_ChIP-PET_HCT116_Human1.30874536
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30677186
63* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.29802931
64ZNF263_19887448_ChIP-Seq_K562_Human1.29573131
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29290847
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29061765
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28127485
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27927844
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27122216
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26714693
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25969664
72* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24734862
73CLOCK_20551151_ChIP-Seq_293T_Human1.24325293
74EZH2_22144423_ChIP-Seq_EOC_Human1.24202139
75* TP53_23651856_ChIP-Seq_MEFs_Mouse1.23282963
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.23256045
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.23155607
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23026637
79SA1_22415368_ChIP-Seq_MEFs_Mouse1.22559661
80TP53_22127205_ChIP-Seq_IMR90_Human1.19910303
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19812034
82P53_21459846_ChIP-Seq_SAOS-2_Human1.19708022
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18907899
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18868153
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.18411671
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17828743
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.17649232
88CTCF_20526341_ChIP-Seq_ESCs_Human1.17433281
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16262933
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.15664957
91AR_25329375_ChIP-Seq_VCAP_Human1.14769783
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14034555
93DROSHA_22980978_ChIP-Seq_HELA_Human1.13818814
94JUN_21703547_ChIP-Seq_K562_Human1.13040235
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12623033
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12623033
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11953187
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11024204
99STAT3_23295773_ChIP-Seq_U87_Human1.10998531
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10748335
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10702789
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10204743
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09796461
104AR_21909140_ChIP-Seq_LNCAP_Human1.09614199
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08485699
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.08178828
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07804826
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07381322
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07319408
110EOMES_21245162_ChIP-Seq_HESCs_Human1.06119358
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05585020
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05523507
113RNF2_27304074_Chip-Seq_NSC_Mouse1.05507878
114SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05235071
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05186126
116FUS_26573619_Chip-Seq_HEK293_Human1.04350894
117BCAT_22108803_ChIP-Seq_LS180_Human1.04134764
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.02642105
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02046550
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01707637
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.01477641
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01027738
123* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.00115475
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99476115
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99446648
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.99398473
127* RARB_27405468_Chip-Seq_BRAIN_Mouse0.99110911
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98769300
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98420024
130SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98259686
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97540066
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.97522879
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97232296
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97186047
135REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96832738
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96518188
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.95897710
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94837192
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94698180
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93956109
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92986596
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92712771
143P53_22387025_ChIP-Seq_ESCs_Mouse0.91201186
144RUNX2_22187159_ChIP-Seq_PCA_Human0.91148792
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90209307
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90127273
147KDM2B_26808549_Chip-Seq_REH_Human0.89204085
148KDM2B_26808549_Chip-Seq_DND41_Human0.88725151
149WT1_19549856_ChIP-ChIP_CCG9911_Human0.87194514
150OCT4_20526341_ChIP-Seq_ESCs_Human0.85793630
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85226393
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85131600
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84557036
154SOX9_26525672_Chip-Seq_HEART_Mouse0.83498591
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82883277
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81554724
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81492816
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81005744
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.80947934
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80512656
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.80257310
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.79122245
163NCOR_22424771_ChIP-Seq_293T_Human0.79102240
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79044307
165LXR_22158963_ChIP-Seq_LIVER_Mouse0.78885089
166TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78723567
167RING1B_27294783_Chip-Seq_ESCs_Mouse0.78663455
168KDM2B_26808549_Chip-Seq_K562_Human0.78475829
169TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78086597
170SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.77434903
171RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77365613
172ER_23166858_ChIP-Seq_MCF-7_Human0.77297359
173REST_21632747_ChIP-Seq_MESCs_Mouse0.76888073
174SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74896121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.86446805
2MP0005410_abnormal_fertilization4.91331339
3MP0000920_abnormal_myelination3.93296644
4MP0005503_abnormal_tendon_morphology3.33411114
5MP0005623_abnormal_meninges_morphology2.78372196
6MP0003690_abnormal_glial_cell2.70567060
7MP0005275_abnormal_skin_tensile2.49662814
8MP0003195_calcinosis2.41387934
9MP0003329_amyloid_beta_deposits2.23042704
10MP0001958_emphysema2.18937361
11MP0003950_abnormal_plasma_membrane2.16417191
12MP0003634_abnormal_glial_cell2.15536627
13MP0003806_abnormal_nucleotide_metabolis2.10707804
14MP0009840_abnormal_foam_cell2.10687997
15MP0001984_abnormal_olfaction2.07980192
16MP0009780_abnormal_chondrocyte_physiolo1.98499942
17MP0000003_abnormal_adipose_tissue1.92472448
18MP0005257_abnormal_intraocular_pressure1.90918558
19MP0003698_abnormal_male_reproductive1.81938390
20MP0004270_analgesia1.77705079
21MP0001348_abnormal_lacrimal_gland1.72400470
22MP0002090_abnormal_vision1.71590958
23MP0001293_anophthalmia1.71142351
24MP0004233_abnormal_muscle_weight1.69857296
25MP0004133_heterotaxia1.66896001
26MP0004272_abnormal_basement_membrane1.65559037
27MP0003283_abnormal_digestive_organ1.63772626
28MP0008789_abnormal_olfactory_epithelium1.60738304
29MP0005499_abnormal_olfactory_system1.58767904
30MP0005394_taste/olfaction_phenotype1.58767904
31MP0002060_abnormal_skin_morphology1.58001935
32MP0000604_amyloidosis1.57290370
33MP0003632_abnormal_nervous_system1.52707837
34MP0002102_abnormal_ear_morphology1.52421668
35MP0010030_abnormal_orbit_morphology1.49278506
36MP0005171_absent_coat_pigmentation1.47401649
37MP0001529_abnormal_vocalization1.47147939
38MP0002272_abnormal_nervous_system1.46559196
39MP0003075_altered_response_to1.46411145
40MP0005248_abnormal_Harderian_gland1.46180486
41MP0001929_abnormal_gametogenesis1.45406159
42MP0005076_abnormal_cell_differentiation1.43607947
43MP0004859_abnormal_synaptic_plasticity1.42247926
44MP0000013_abnormal_adipose_tissue1.42021180
45MP0004858_abnormal_nervous_system1.41456978
46MP0003705_abnormal_hypodermis_morpholog1.39846455
47MP0000049_abnormal_middle_ear1.35232718
48MP0004134_abnormal_chest_morphology1.34276956
49MP0003941_abnormal_skin_development1.33526633
50MP0009384_cardiac_valve_regurgitation1.31743569
51MP0008260_abnormal_autophagy1.31375232
52MP0002909_abnormal_adrenal_gland1.28891379
53MP0001270_distended_abdomen1.28564283
54MP0003385_abnormal_body_wall1.25111199
55MP0004885_abnormal_endolymph1.23998556
56MP0003880_abnormal_central_pattern1.23329617
57MP0002108_abnormal_muscle_morphology1.22792301
58MP0001486_abnormal_startle_reflex1.21746542
59MP0002210_abnormal_sex_determination1.21230483
60MP0000762_abnormal_tongue_morphology1.20961453
61MP0002234_abnormal_pharynx_morphology1.20720970
62MP0003123_paternal_imprinting1.20164097
63MP0006276_abnormal_autonomic_nervous1.19601171
64MP0010386_abnormal_urinary_bladder1.18728313
65MP0001299_abnormal_eye_distance/1.18013579
66MP0005508_abnormal_skeleton_morphology1.16344872
67MP0003279_aneurysm1.15457538
68MP0002653_abnormal_ependyma_morphology1.13254436
69MP0002295_abnormal_pulmonary_circulatio1.13098883
70MP0010368_abnormal_lymphatic_system1.12414767
71MP0006054_spinal_hemorrhage1.11892828
72MP0000955_abnormal_spinal_cord1.10042841
73MP0003755_abnormal_palate_morphology1.08022782
74MP0003011_delayed_dark_adaptation1.06046909
75MP0005375_adipose_tissue_phenotype1.05663533
76MP0000647_abnormal_sebaceous_gland1.05644847
77MP0002064_seizures1.05614711
78MP0001243_abnormal_dermal_layer1.05152205
79MP0002229_neurodegeneration1.04730171
80MP0005187_abnormal_penis_morphology1.03766840
81MP0003091_abnormal_cell_migration1.03723202
82MP0000639_abnormal_adrenal_gland1.03298444
83* MP0002161_abnormal_fertility/fecundity1.02678034
84MP0001145_abnormal_male_reproductive1.01471990
85MP0004811_abnormal_neuron_physiology0.99433845
86MP0003566_abnormal_cell_adhesion0.99119304
87MP0002233_abnormal_nose_morphology0.99082338
88MP0000428_abnormal_craniofacial_morphol0.99019354
89MP0005551_abnormal_eye_electrophysiolog0.98804762
90MP0003631_nervous_system_phenotype0.98231587
91MP0000579_abnormal_nail_morphology0.96150783
92MP0001542_abnormal_bone_strength0.95492811
93MP0001177_atelectasis0.95343874
94MP0002736_abnormal_nociception_after0.95240246
95MP0002063_abnormal_learning/memory/cond0.93126702
96MP0003115_abnormal_respiratory_system0.93089054
97MP0000751_myopathy0.92884519
98MP0005023_abnormal_wound_healing0.91389124
99MP0005595_abnormal_vascular_smooth0.89875559
100MP0000534_abnormal_ureter_morphology0.89828674
101MP0002572_abnormal_emotion/affect_behav0.89577537
102MP0000750_abnormal_muscle_regeneration0.89149997
103MP0008877_abnormal_DNA_methylation0.89006827
104MP0001661_extended_life_span0.87714476
105MP0000163_abnormal_cartilage_morphology0.87130215
106MP0005197_abnormal_uvea_morphology0.85923934
107MP0003937_abnormal_limbs/digits/tail_de0.85670098
108MP0004742_abnormal_vestibular_system0.84946053
109MP0001915_intracranial_hemorrhage0.84793802
110MP0009250_abnormal_appendicular_skeleto0.84756397
111MP0004142_abnormal_muscle_tone0.84728782
112MP0009745_abnormal_behavioral_response0.84540183
113MP0005670_abnormal_white_adipose0.83886461
114MP0003122_maternal_imprinting0.83461476
115MP0000537_abnormal_urethra_morphology0.83035538
116MP0002896_abnormal_bone_mineralization0.82426434
117* MP0002557_abnormal_social/conspecific_i0.81619727
118MP0003633_abnormal_nervous_system0.81599269
119MP0001968_abnormal_touch/_nociception0.81471022
120MP0002697_abnormal_eye_size0.81138201
121MP0002160_abnormal_reproductive_system0.80422211
122MP0003191_abnormal_cellular_cholesterol0.80194195
123MP0009046_muscle_twitch0.80030736
124MP0000747_muscle_weakness0.78788669
125MP0000462_abnormal_digestive_system0.78711938
126MP0001879_abnormal_lymphatic_vessel0.77821587
127MP0000383_abnormal_hair_follicle0.77583282
128MP0000778_abnormal_nervous_system0.76394483
129MP0002734_abnormal_mechanical_nocicepti0.76351668
130MP0000653_abnormal_sex_gland0.75049542
131MP0000538_abnormal_urinary_bladder0.74347651
132MP0000516_abnormal_urinary_system0.74018963
133MP0005367_renal/urinary_system_phenotyp0.74018963
134MP0001502_abnormal_circadian_rhythm0.73798929
135MP0000733_abnormal_muscle_development0.73261501
136MP0002254_reproductive_system_inflammat0.72203026
137MP0006082_CNS_inflammation0.70589576
138MP0003635_abnormal_synaptic_transmissio0.70164396
139MP0002882_abnormal_neuron_morphology0.69793608
140MP0001905_abnormal_dopamine_level0.68937007
141MP0001730_embryonic_growth_arrest0.67257297
142MP0002168_other_aberrant_phenotype0.66992498
143MP0002282_abnormal_trachea_morphology0.62718661
144MP0002066_abnormal_motor_capabilities/c0.61846541
145MP0002938_white_spotting0.60967159
146MP0002092_abnormal_eye_morphology0.60398386
147MP0005195_abnormal_posterior_eye0.60141236
148MP0002733_abnormal_thermal_nociception0.59512207
149MP0003942_abnormal_urinary_system0.57668079

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.15258638
2Protrusio acetabuli (HP:0003179)4.91945851
3Premature rupture of membranes (HP:0001788)4.33950065
4Atrophic scars (HP:0001075)4.33587800
5Cerebral inclusion bodies (HP:0100314)4.09874568
6Limb dystonia (HP:0002451)4.07069999
7Broad metatarsal (HP:0001783)3.90253467
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.90146844
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.90146844
10Delayed gross motor development (HP:0002194)3.62170794
11Ankle contracture (HP:0006466)3.33589753
12Coronal craniosynostosis (HP:0004440)3.32505535
13Shallow orbits (HP:0000586)3.23272213
14Cervical subluxation (HP:0003308)3.13028822
15Turricephaly (HP:0000262)3.06269507
16Cerebral hypomyelination (HP:0006808)2.99709901
17Sensory axonal neuropathy (HP:0003390)2.99266189
18Vascular tortuosity (HP:0004948)2.96828608
19Abnormality of dentin (HP:0010299)2.96281742
20Bell-shaped thorax (HP:0001591)2.94855181
21Supranuclear gaze palsy (HP:0000605)2.87574781
22Abnormality of the corticospinal tract (HP:0002492)2.80091677
23Bladder diverticulum (HP:0000015)2.71071443
24Buphthalmos (HP:0000557)2.71047542
25Cerebellar dysplasia (HP:0007033)2.70840049
26Insidious onset (HP:0003587)2.63581129
27Termporal pattern (HP:0011008)2.63581129
28Gait imbalance (HP:0002141)2.62466470
29Spastic gait (HP:0002064)2.61385614
30Arterial tortuosity (HP:0005116)2.60689294
31Type II lissencephaly (HP:0007260)2.59385767
32Vertebral compression fractures (HP:0002953)2.58207456
33Peritonitis (HP:0002586)2.56882612
34Retinal dysplasia (HP:0007973)2.56590429
35Infantile muscular hypotonia (HP:0008947)2.55003994
36Mitral stenosis (HP:0001718)2.52395494
37Congenital primary aphakia (HP:0007707)2.44908125
38Soft skin (HP:0000977)2.44194786
39Anteriorly placed anus (HP:0001545)2.42194551
40Wrist flexion contracture (HP:0001239)2.42037606
41Stridor (HP:0010307)2.39353214
42Nephrogenic diabetes insipidus (HP:0009806)2.35798194
43Intention tremor (HP:0002080)2.33886063
44Ankle clonus (HP:0011448)2.31820267
45Distal upper limb amyotrophy (HP:0007149)2.29941277
46Upper limb amyotrophy (HP:0009129)2.29941277
47Cerebral hemorrhage (HP:0001342)2.29049099
48Medial flaring of the eyebrow (HP:0010747)2.26469801
49Blue sclerae (HP:0000592)2.22705211
50Action tremor (HP:0002345)2.20779444
51Follicular hyperkeratosis (HP:0007502)2.20408226
52Broad distal phalanx of finger (HP:0009836)2.19124998
53Absent/shortened dynein arms (HP:0200106)2.17438827
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.17438827
55Aortic dissection (HP:0002647)2.16621074
56Amblyopia (HP:0000646)2.15370711
57Biconcave vertebral bodies (HP:0004586)2.15024420
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14939212
59Autoamputation (HP:0001218)2.14354184
60Wormian bones (HP:0002645)2.14241445
61Spinal rigidity (HP:0003306)2.13087899
62Clonus (HP:0002169)2.11427200
63Flat cornea (HP:0007720)2.10930145
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08363159
65Abnormality of polysaccharide metabolism (HP:0011012)2.07744719
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07744719
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07744719
68Overriding aorta (HP:0002623)2.07472350
69Occipital encephalocele (HP:0002085)2.04836712
70Mucopolysacchariduria (HP:0008155)2.04400749
71Urinary glycosaminoglycan excretion (HP:0003541)2.04400749
72Abnormality of the musculature of the pelvis (HP:0001469)2.02725200
73Abnormality of the hip-girdle musculature (HP:0001445)2.02725200
74Small epiphyses (HP:0010585)2.01881966
75Split foot (HP:0001839)2.00789892
76Shoulder girdle muscle weakness (HP:0003547)1.99164374
77Long toe (HP:0010511)1.98379725
78Protruding ear (HP:0000411)1.98347962
79Aortic aneurysm (HP:0004942)1.98334716
80Hydroureter (HP:0000072)1.98195450
81CNS hypomyelination (HP:0003429)1.97555799
82Spastic tetraparesis (HP:0001285)1.96052230
83Clumsiness (HP:0002312)1.95936983
84Alacrima (HP:0000522)1.95101000
85Increased variability in muscle fiber diameter (HP:0003557)1.93947166
86Congenital stationary night blindness (HP:0007642)1.93869284
87Increased corneal curvature (HP:0100692)1.93306803
88Keratoconus (HP:0000563)1.93306803
89Neonatal short-limb short stature (HP:0008921)1.93110316
90Slender build (HP:0001533)1.91552882
91Aplasia/Hypoplasia of the lens (HP:0008063)1.91547151
92Cholecystitis (HP:0001082)1.91443259
93Abnormal gallbladder physiology (HP:0012438)1.91443259
94Torticollis (HP:0000473)1.91429891
95Neoplasm of the oral cavity (HP:0100649)1.90325496
96Postural instability (HP:0002172)1.90173581
97Hyperextensible skin (HP:0000974)1.90169535
98Vaginal atresia (HP:0000148)1.89534483
99Ulnar bowing (HP:0003031)1.88970613
100Upper limb muscle weakness (HP:0003484)1.88307844
101Peripheral hypomyelination (HP:0007182)1.88038018
102Back pain (HP:0003418)1.87124792
103Pulmonary artery stenosis (HP:0004415)1.85887280
104Drooling (HP:0002307)1.85337102
105Bowel diverticulosis (HP:0005222)1.85067493
106Ovoid vertebral bodies (HP:0003300)1.83703419
107Fragile skin (HP:0001030)1.83548342
108Hand muscle atrophy (HP:0009130)1.82864033
109Abnormality of the nasal mucosa (HP:0000433)1.81484054
110Genital tract atresia (HP:0001827)1.80958852
111Polyphagia (HP:0002591)1.80869211
112Urinary incontinence (HP:0000020)1.80760185
113Deep venous thrombosis (HP:0002625)1.80033069
114Dysmetria (HP:0001310)1.79929408
115Limb-girdle muscle weakness (HP:0003325)1.79047979
116Scanning speech (HP:0002168)1.78536866
117Abnormality of the lower motor neuron (HP:0002366)1.76192258
118Hypoventilation (HP:0002791)1.75700070
119Onion bulb formation (HP:0003383)1.75294571
120Abnormal delivery (HP:0001787)1.75193160
121Congenital glaucoma (HP:0001087)1.75071093
122Progressive inability to walk (HP:0002505)1.74543853
123Limb-girdle muscle atrophy (HP:0003797)1.74477633
124Hammertoe (HP:0001765)1.74355394
125Abnormality of the phalanges of the hallux (HP:0010057)1.73824280
126Hypodontia (HP:0000668)1.73666272
127Natal tooth (HP:0000695)1.73045053
128Cardiovascular calcification (HP:0011915)1.72484845
129Spastic tetraplegia (HP:0002510)1.72044958
130Hypokinesia (HP:0002375)1.71605405
131Spastic paraparesis (HP:0002313)1.70853826
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70204076
133Lissencephaly (HP:0001339)1.69558417
134Insomnia (HP:0100785)1.69283890
135Lower limb muscle weakness (HP:0007340)1.68655376
136Focal dystonia (HP:0004373)1.67679181
137Abnormality of skull ossification (HP:0002703)1.67340343
138Craniofacial dystonia (HP:0012179)1.67148969
139Premature skin wrinkling (HP:0100678)1.65571783
140Genu recurvatum (HP:0002816)1.64808007
141Cerebral aneurysm (HP:0004944)1.63961604
142Joint stiffness (HP:0001387)1.63609266
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.63254189
144Osteolytic defects of the hand bones (HP:0009699)1.63254189
145Short nail (HP:0001799)1.63068473
146Joint laxity (HP:0001388)1.62655915
147Failure to thrive in infancy (HP:0001531)1.62346834
148Loss of speech (HP:0002371)1.61589772
149Neoplasm of the heart (HP:0100544)1.60986444
150Striae distensae (HP:0001065)1.60719946
151Intrahepatic cholestasis (HP:0001406)1.60350583
152Dysostosis multiplex (HP:0000943)1.60273943
153Complement deficiency (HP:0004431)1.60177638
154Mitral regurgitation (HP:0001653)1.59992645
155Chronic otitis media (HP:0000389)1.59960292
156Excessive salivation (HP:0003781)1.59749118
157Recurrent corneal erosions (HP:0000495)1.59151415
158Anterior segment dysgenesis (HP:0007700)1.58647068
159Wide anterior fontanel (HP:0000260)1.57926638
160Absent speech (HP:0001344)1.57905965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.90930790
2MET3.47036371
3STK393.42054760
4CASK3.26289192
5PRPF4B3.18366857
6MARK12.96885226
7MAP2K72.74376733
8ARAF2.73801951
9MAP3K42.70694248
10NTRK12.58870519
11ICK2.53138397
12EPHB12.46782640
13STK38L2.42993000
14SIK12.42897525
15KSR22.37757235
16TRIM282.29857259
17BMX2.13937101
18BCR2.09268035
19LIMK12.07500654
20MAP3K121.99339341
21PLK21.97030996
22PRKD31.90252032
23PIM21.84167477
24MAP3K131.82351759
25FGFR21.77577208
26EPHB21.77209371
27UHMK11.74828632
28BCKDK1.74050721
29CDK191.73670522
30PAK61.71951480
31STK381.70807916
32OXSR11.65745135
33BUB11.61520658
34MAP3K61.58988853
35MAPKAPK51.57630166
36NEK11.49040399
37MAP2K41.48933659
38LATS21.48203129
39ERBB41.43798494
40MAP4K21.40819827
41PTK2B1.40677861
42MAP3K91.37886415
43TGFBR11.32354078
44PAK31.25916654
45ERN11.24840898
46PKN11.24798041
47CDC71.24178874
48PTK21.18600223
49CSNK1A1L1.17168377
50MYLK1.16434657
51WNK11.15098883
52TNIK1.12083312
53ERBB31.10369457
54KSR11.10291929
55PRKCE1.09821089
56NEK21.09742120
57CSF1R1.08850730
58PRKCG1.03474336
59MARK31.03356935
60CDK141.02773697
61GRK71.01127074
62DDR21.01074058
63FLT31.00785936
64TESK20.99936291
65MAP3K100.99697206
66LMTK20.99561215
67CSNK1G30.98728768
68ADRBK20.98600462
69DYRK30.98021368
70FGR0.97350133
71RPS6KA50.97049092
72SIK30.94354838
73DYRK1A0.93607104
74GRK50.92069984
75FRK0.91693591
76ROCK20.88293970
77ADRBK10.88051213
78EPHA40.86313119
79LATS10.83107853
80ABL20.82910876
81MAP3K50.82842329
82CAMK2A0.80471594
83PAK40.79542915
84MAPK130.79128808
85EPHA30.76739294
86NTRK20.72974826
87IRAK20.72421881
88PRKD20.72231055
89CDC42BPA0.72220751
90CDK150.71158918
91CSNK1G10.70951515
92FER0.70091732
93BRSK20.69461415
94WNK40.68830295
95DYRK1B0.68684730
96TESK10.68433159
97CSNK1G20.68057731
98CAMK2D0.67254369
99STK30.66659412
100SIK20.66504141
101IRAK10.66336725
102CDK11A0.65965239
103PINK10.65555576
104CDK180.65518340
105MARK20.62141738
106PAK10.61482462
107AKT30.61286054
108RPS6KA40.61282138
109PDK30.60422492
110PDK40.60422492
111KIT0.59946061
112BRAF0.59661613
113GRK10.59404206
114CLK10.58511368
115MINK10.58243684
116PAK20.58012149
117TGFBR20.55812204
118EIF2AK30.55244901
119PNCK0.54096891
120CSNK1D0.53561234
121MOS0.53518823
122CAMK2G0.52758273
123CAMK2B0.52651843
124CDK50.52104987
125PRKCH0.51976834
126TYRO30.48855528
127MTOR0.48838008
128ALK0.48486700
129PDGFRB0.47475825
130FGFR10.46429698
131ROCK10.46369606
132PASK0.46160969
133MUSK0.45326859
134LRRK20.43728954
135STK160.43462149
136CAMKK10.41774802
137PDK10.41707829
138MAP3K80.41311813
139DYRK20.40781570
140TIE10.39913105
141NEK90.39541448
142PDPK10.38156070
143ACVR1B0.37934621
144RIPK10.37626621
145MAP3K20.37441151
146INSR0.36256899
147WNK30.36007707
148RET0.35996945
149FYN0.34604880
150DAPK30.32719935
151PDGFRA0.32480841
152SGK2230.31540487
153SGK4940.31540487

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.39380118
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.98217343
3Nitrogen metabolism_Homo sapiens_hsa009103.52057334
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90748809
5Fatty acid elongation_Homo sapiens_hsa000622.64772856
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.56635329
7Prion diseases_Homo sapiens_hsa050202.52908539
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51105905
9DNA replication_Homo sapiens_hsa030302.13633028
10Malaria_Homo sapiens_hsa051442.06860898
11Collecting duct acid secretion_Homo sapiens_hsa049661.96525216
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79933443
13Ether lipid metabolism_Homo sapiens_hsa005651.75056913
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67735755
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.67436105
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65786910
17GABAergic synapse_Homo sapiens_hsa047271.58873159
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56531070
19Nicotine addiction_Homo sapiens_hsa050331.54036775
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48113898
21ECM-receptor interaction_Homo sapiens_hsa045121.47467785
22Hedgehog signaling pathway_Homo sapiens_hsa043401.46287127
23Alcoholism_Homo sapiens_hsa050341.41252791
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38487632
25Complement and coagulation cascades_Homo sapiens_hsa046101.36788827
26Folate biosynthesis_Homo sapiens_hsa007901.35142262
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35019487
28Morphine addiction_Homo sapiens_hsa050321.33307247
29Sulfur metabolism_Homo sapiens_hsa009201.31846881
30Sulfur relay system_Homo sapiens_hsa041221.30759137
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29720663
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26357589
33Mismatch repair_Homo sapiens_hsa034301.20436921
34Circadian entrainment_Homo sapiens_hsa047131.18086590
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17497147
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14545981
37African trypanosomiasis_Homo sapiens_hsa051431.12628136
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10257921
39Regulation of autophagy_Homo sapiens_hsa041401.09034861
40Insulin secretion_Homo sapiens_hsa049111.04685868
41Systemic lupus erythematosus_Homo sapiens_hsa053221.04439105
42Synaptic vesicle cycle_Homo sapiens_hsa047211.01490187
43Circadian rhythm_Homo sapiens_hsa047100.99402757
44Protein export_Homo sapiens_hsa030600.99328464
45Renin secretion_Homo sapiens_hsa049240.98516447
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98410696
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97941323
48Cocaine addiction_Homo sapiens_hsa050300.96778079
49Axon guidance_Homo sapiens_hsa043600.95761195
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95758214
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92528471
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92521176
53Biosynthesis of amino acids_Homo sapiens_hsa012300.91713289
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.91496197
55Fatty acid biosynthesis_Homo sapiens_hsa000610.91072857
56Vitamin B6 metabolism_Homo sapiens_hsa007500.90396398
57Arginine and proline metabolism_Homo sapiens_hsa003300.87650969
58Nucleotide excision repair_Homo sapiens_hsa034200.87457571
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.86651847
60Linoleic acid metabolism_Homo sapiens_hsa005910.86171740
61Glutamatergic synapse_Homo sapiens_hsa047240.85959347
62Butanoate metabolism_Homo sapiens_hsa006500.85574942
63Basal cell carcinoma_Homo sapiens_hsa052170.85473458
64Staphylococcus aureus infection_Homo sapiens_hsa051500.84271215
65Oocyte meiosis_Homo sapiens_hsa041140.84185599
66Renal cell carcinoma_Homo sapiens_hsa052110.82602890
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.82314317
68One carbon pool by folate_Homo sapiens_hsa006700.81154395
69N-Glycan biosynthesis_Homo sapiens_hsa005100.81040313
70Dorso-ventral axis formation_Homo sapiens_hsa043200.80440145
71Base excision repair_Homo sapiens_hsa034100.79693236
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79666017
73Sphingolipid metabolism_Homo sapiens_hsa006000.78970809
74Melanoma_Homo sapiens_hsa052180.78898956
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78291302
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77084580
77Phototransduction_Homo sapiens_hsa047440.76355271
78Vibrio cholerae infection_Homo sapiens_hsa051100.74702689
79Phenylalanine metabolism_Homo sapiens_hsa003600.72321940
80Fatty acid metabolism_Homo sapiens_hsa012120.71904968
81Pentose phosphate pathway_Homo sapiens_hsa000300.71816425
82TGF-beta signaling pathway_Homo sapiens_hsa043500.70712047
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70556488
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70043740
85Dilated cardiomyopathy_Homo sapiens_hsa054140.69966820
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68626704
87Taste transduction_Homo sapiens_hsa047420.68541425
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68137679
89Endocytosis_Homo sapiens_hsa041440.67030006
90Dopaminergic synapse_Homo sapiens_hsa047280.66986515
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66754631
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66320291
93Pyruvate metabolism_Homo sapiens_hsa006200.65587940
94Tyrosine metabolism_Homo sapiens_hsa003500.63835044
95PPAR signaling pathway_Homo sapiens_hsa033200.63804787
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61965446
97Protein digestion and absorption_Homo sapiens_hsa049740.61044127
98p53 signaling pathway_Homo sapiens_hsa041150.61017969
99Serotonergic synapse_Homo sapiens_hsa047260.59372184
100Amoebiasis_Homo sapiens_hsa051460.58763717
101Selenocompound metabolism_Homo sapiens_hsa004500.58693062
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.57115298
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.55721384
104beta-Alanine metabolism_Homo sapiens_hsa004100.55622565
105Salmonella infection_Homo sapiens_hsa051320.55498828
106Lysosome_Homo sapiens_hsa041420.54780946
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53864299
108Proteasome_Homo sapiens_hsa030500.52813968
109Oxidative phosphorylation_Homo sapiens_hsa001900.52319234
110Bladder cancer_Homo sapiens_hsa052190.50705092
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50483967
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50427933
113Mineral absorption_Homo sapiens_hsa049780.50023390
114Gap junction_Homo sapiens_hsa045400.49524300
115Adherens junction_Homo sapiens_hsa045200.49220157
116Thyroid hormone synthesis_Homo sapiens_hsa049180.49170334
117Viral carcinogenesis_Homo sapiens_hsa052030.49105025
118cAMP signaling pathway_Homo sapiens_hsa040240.48941977
119Melanogenesis_Homo sapiens_hsa049160.48193773
120Ras signaling pathway_Homo sapiens_hsa040140.48066582
121Shigellosis_Homo sapiens_hsa051310.47631082
122Phagosome_Homo sapiens_hsa041450.46387072
123Peroxisome_Homo sapiens_hsa041460.45834777
124ABC transporters_Homo sapiens_hsa020100.45497228
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45170866
126Other glycan degradation_Homo sapiens_hsa005110.43016725
127Proteoglycans in cancer_Homo sapiens_hsa052050.42497534
128Long-term depression_Homo sapiens_hsa047300.42478138
129Rheumatoid arthritis_Homo sapiens_hsa053230.40967679
130Cholinergic synapse_Homo sapiens_hsa047250.39420128
131Glutathione metabolism_Homo sapiens_hsa004800.39279137
132Focal adhesion_Homo sapiens_hsa045100.38967199
133Hippo signaling pathway_Homo sapiens_hsa043900.38179042
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37520892
135Rap1 signaling pathway_Homo sapiens_hsa040150.37174191
136Pertussis_Homo sapiens_hsa051330.36917528
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36632256
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36498709
139Arginine biosynthesis_Homo sapiens_hsa002200.36026880
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35217171
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35055885
142Tight junction_Homo sapiens_hsa045300.34533452
143Amphetamine addiction_Homo sapiens_hsa050310.33255745

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