TPST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78539939
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78539939
3neutrophil activation involved in immune response (GO:0002283)5.52290579
4ribosomal small subunit assembly (GO:0000028)4.93026487
5antigen processing and presentation of endogenous antigen (GO:0019883)4.75055534
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64486151
7negative regulation of cell killing (GO:0031342)4.64486151
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.33006057
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32802965
10antigen processing and presentation via MHC class Ib (GO:0002475)4.28450510
11positive regulation of gamma-delta T cell activation (GO:0046645)4.24975476
12DNA deamination (GO:0045006)4.24394973
13viral transcription (GO:0019083)3.77067002
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.76602252
15regulation of gamma-delta T cell differentiation (GO:0045586)3.74641227
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74563095
17regulation of mast cell degranulation (GO:0043304)3.73391665
18thrombin receptor signaling pathway (GO:0070493)3.64317296
19positive regulation of mast cell activation (GO:0033005)3.64292455
20translational termination (GO:0006415)3.62098619
21protein targeting to ER (GO:0045047)3.61965416
22cotranslational protein targeting to membrane (GO:0006613)3.61137198
23neutrophil activation (GO:0042119)3.60115365
24regulation of natural killer cell mediated immunity (GO:0002715)3.57507627
25regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.57507627
26Golgi transport vesicle coating (GO:0048200)3.56091532
27COPI coating of Golgi vesicle (GO:0048205)3.56091532
28regulation of mast cell activation (GO:0033003)3.55716023
29regulation of mast cell activation involved in immune response (GO:0033006)3.55076602
30negative regulation of erythrocyte differentiation (GO:0045647)3.49965067
31protein localization to endoplasmic reticulum (GO:0070972)3.46932290
32leukocyte migration involved in inflammatory response (GO:0002523)3.46170036
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42604204
34granulocyte activation (GO:0036230)3.40500690
35regulation of gamma-delta T cell activation (GO:0046643)3.34664546
36translational elongation (GO:0006414)3.33144560
37positive regulation by symbiont of host defense response (GO:0052509)3.30526355
38modulation by symbiont of host defense response (GO:0052031)3.30526355
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30526355
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30526355
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.30526355
42modulation by symbiont of host immune response (GO:0052553)3.30526355
43regulation of alpha-beta T cell proliferation (GO:0046640)3.28079247
44leukocyte degranulation (GO:0043299)3.25401569
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25153403
46regulation of B cell receptor signaling pathway (GO:0050855)3.24323704
47response to interferon-beta (GO:0035456)3.24140907
48detection of other organism (GO:0098543)3.17170294
49positive regulation of interleukin-17 production (GO:0032740)3.16336055
50cellular extravasation (GO:0045123)3.15298917
51negative regulation of leukocyte mediated immunity (GO:0002704)3.14143416
52detection of bacterium (GO:0016045)3.13040431
53positive regulation of natural killer cell mediated immunity (GO:0002717)3.12290672
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11705014
55myeloid cell activation involved in immune response (GO:0002275)3.11695117
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11057881
57regulation of platelet aggregation (GO:0090330)3.11022357
58response to peptidoglycan (GO:0032494)3.07939087
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.07624626
60response to interleukin-15 (GO:0070672)3.07215043
61regulation of leukocyte degranulation (GO:0043300)3.06233060
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05616131
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04084507
64regulation of platelet activation (GO:0010543)3.02751523
65signal peptide processing (GO:0006465)3.02013301
66respiratory burst (GO:0045730)3.01101707
67ribosomal small subunit biogenesis (GO:0042274)2.94554958
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.91492402
69positive regulation of mast cell degranulation (GO:0043306)2.91492402
70positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91312744
71interferon-gamma production (GO:0032609)2.90995894
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88319479
73regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87079908
74viral life cycle (GO:0019058)2.86702368
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84206441
76negative regulation of T cell apoptotic process (GO:0070233)2.84116484
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84081607
78megakaryocyte development (GO:0035855)2.81397967
79positive regulation of B cell differentiation (GO:0045579)2.79481024
80cellular response to interleukin-15 (GO:0071350)2.78968341
81regulation of interleukin-17 production (GO:0032660)2.78235700
82positive thymic T cell selection (GO:0045059)2.77178590
83lipoxygenase pathway (GO:0019372)2.75999384
84regulation of T cell mediated cytotoxicity (GO:0001914)2.75967439
85translational initiation (GO:0006413)2.75768284
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74788712
87mature B cell differentiation involved in immune response (GO:0002313)2.74538330
88autophagic vacuole fusion (GO:0000046)2.73264180
89protein retention in ER lumen (GO:0006621)2.71896875
90positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.70605217
91formation of translation preinitiation complex (GO:0001731)2.70205869
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69316947
93negative regulation of cytokine production involved in immune response (GO:0002719)2.69278406
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67940222
95negative regulation of innate immune response (GO:0045824)2.66175085
96NIK/NF-kappaB signaling (GO:0038061)2.65538582
97positive regulation of B cell mediated immunity (GO:0002714)2.64871602
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.64871602
99response to interferon-alpha (GO:0035455)2.64073630
100maturation of SSU-rRNA (GO:0030490)2.62903663
101blood coagulation, intrinsic pathway (GO:0007597)2.60616829
102positive regulation of antigen processing and presentation (GO:0002579)2.59595975
103regulation of B cell differentiation (GO:0045577)2.59237142
104positive regulation of lamellipodium assembly (GO:0010592)2.58462620
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57793296
106positive T cell selection (GO:0043368)2.57766469
107negative regulation of phagocytosis (GO:0050765)2.56960522
108positive regulation of granulocyte differentiation (GO:0030854)2.56868430
109cellular protein complex disassembly (GO:0043624)2.56594909
110response to type I interferon (GO:0034340)2.56114670
111lymphocyte chemotaxis (GO:0048247)2.56023433
112dendritic cell chemotaxis (GO:0002407)2.55663323
113type I interferon signaling pathway (GO:0060337)2.54743733
114cellular response to type I interferon (GO:0071357)2.54743733
115detection of external biotic stimulus (GO:0098581)2.54496423
116response to host immune response (GO:0052572)2.54101799
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54101799
118regulation of cell killing (GO:0031341)2.53888623
119purinergic nucleotide receptor signaling pathway (GO:0035590)2.53646476
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52565111
121leukocyte aggregation (GO:0070486)2.51523392
122regulation of regulatory T cell differentiation (GO:0045589)2.51474884
123regulation of response to interferon-gamma (GO:0060330)2.51190042
124negative regulation of stress fiber assembly (GO:0051497)2.50701947
125T cell selection (GO:0045058)2.50373368
126regulation of leukocyte mediated immunity (GO:0002703)2.50221258
127actin nucleation (GO:0045010)2.48947827
128protein targeting to membrane (GO:0006612)2.48651934
129regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.46159791
130deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44126699
131purine-containing compound salvage (GO:0043101)2.42795242
132folic acid-containing compound biosynthetic process (GO:0009396)2.41947436
133telomere maintenance via semi-conservative replication (GO:0032201)2.41237289
134cellular response to interferon-beta (GO:0035458)2.40867744
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39660761
136pteridine-containing compound biosynthetic process (GO:0042559)2.38320546
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.38175207
138B cell receptor signaling pathway (GO:0050853)2.37876267
139platelet dense granule organization (GO:0060155)2.37622530
140negative regulation of interleukin-12 production (GO:0032695)2.36519013
141pentose-phosphate shunt (GO:0006098)2.35880996
142antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.35567374
143immunoglobulin mediated immune response (GO:0016064)2.33786356
144T cell migration (GO:0072678)2.29056765
145translation (GO:0006412)2.29050169
146definitive hemopoiesis (GO:0060216)2.27768174
147regulation of necroptotic process (GO:0060544)2.27432456
148angiogenesis involved in wound healing (GO:0060055)2.27252376
149T cell apoptotic process (GO:0070231)2.26522455
150macrophage differentiation (GO:0030225)2.25696350
151regulation of erythrocyte differentiation (GO:0045646)2.24423337
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.24335011
153DNA strand elongation involved in DNA replication (GO:0006271)2.24280863
154B cell mediated immunity (GO:0019724)2.24104152
155endosome to pigment granule transport (GO:0043485)2.23045948
156endosome to melanosome transport (GO:0035646)2.23045948
157regulation of interleukin-12 biosynthetic process (GO:0045075)2.22574055
158platelet aggregation (GO:0070527)2.21973838
159regulation of interferon-beta biosynthetic process (GO:0045357)2.21505404
160negative T cell selection (GO:0043383)2.21443704
161negative regulation of glycoprotein metabolic process (GO:1903019)2.20971319
162negative thymic T cell selection (GO:0045060)2.20887296
163protein complex disassembly (GO:0043241)2.20305600
164regulation of T cell receptor signaling pathway (GO:0050856)2.18595345
165cellular response to zinc ion (GO:0071294)2.18505013
166mast cell activation (GO:0045576)2.18343564
167purine nucleotide salvage (GO:0032261)2.18221410
168mature B cell differentiation (GO:0002335)2.18028375
169proteasome assembly (GO:0043248)2.17896181
170positive regulation of lamellipodium organization (GO:1902745)2.17350274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34038873
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.00091016
3E2F7_22180533_ChIP-Seq_HELA_Human2.66236351
4MYC_22102868_ChIP-Seq_BL_Human2.58893227
5SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51809765
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.41751289
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37266678
8* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32668974
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28267622
10GATA1_19941826_ChIP-Seq_K562_Human2.25844167
11* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.25491566
12* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22056633
13VDR_21846776_ChIP-Seq_THP-1_Human2.19039925
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18125571
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17834621
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14848773
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10642327
18SCL_19346495_ChIP-Seq_HPC-7_Human2.06492100
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05641893
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99393795
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.94317210
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90719914
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88864323
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.86848047
25GATA1_19941827_ChIP-Seq_MEL_Mouse1.86405660
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.85818804
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83883139
28SPI1_23547873_ChIP-Seq_NB4_Human1.81990675
29* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79870153
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79590699
31* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79516901
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74062591
33MAF_26560356_Chip-Seq_TH1_Human1.70938877
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.70518150
35GATA3_27048872_Chip-Seq_THYMUS_Human1.69849245
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68916225
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67549965
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66517622
39MYB_26560356_Chip-Seq_TH2_Human1.65912638
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.64874284
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63205614
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.62846356
43GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62788059
44GATA1_22025678_ChIP-Seq_K562_Human1.59734155
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59035385
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.58928651
47UTX_26944678_Chip-Seq_JUKART_Human1.57680813
48VDR_23849224_ChIP-Seq_CD4+_Human1.57589550
49* RUNX1_22412390_ChIP-Seq_EML_Mouse1.57050334
50GATA2_19941826_ChIP-Seq_K562_Human1.56015697
51MYB_26560356_Chip-Seq_TH1_Human1.52984843
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.51713794
53VDR_24763502_ChIP-Seq_THP-1_Human1.49866233
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49591575
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49056855
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48844247
57GATA3_26560356_Chip-Seq_TH2_Human1.48755977
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48364308
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47057588
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46832686
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45937227
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45081698
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44182452
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44158288
65FOXP3_21729870_ChIP-Seq_TREG_Human1.43470600
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43275528
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42537886
68XRN2_22483619_ChIP-Seq_HELA_Human1.42495489
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38495945
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37348093
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37286535
72* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36263560
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35989316
74BCL6_27268052_Chip-Seq_Bcells_Human1.34682699
75DCP1A_22483619_ChIP-Seq_HELA_Human1.33316033
76GABP_19822575_ChIP-Seq_HepG2_Human1.32438101
77* TCF7_22412390_ChIP-Seq_EML_Mouse1.32380025
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31278916
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30991512
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30835713
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30011248
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29724577
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28835298
84NCOR1_26117541_ChIP-Seq_K562_Human1.26457955
85SPI1_20517297_ChIP-Seq_HL60_Human1.26429258
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25582454
87CIITA_25753668_ChIP-Seq_RAJI_Human1.25527668
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25139661
89MAF_26560356_Chip-Seq_TH2_Human1.23739542
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22375306
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21629993
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.21488380
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21009355
94BCOR_27268052_Chip-Seq_Bcells_Human1.20474531
95TFEB_21752829_ChIP-Seq_HELA_Human1.20233091
96* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19183483
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19135394
98* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18963265
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.17971415
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17560974
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16615711
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16478490
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16363444
104* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16161786
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15860208
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15468610
107VDR_24787735_ChIP-Seq_THP-1_Human1.15148911
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.14601105
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14260548
110LXR_22292898_ChIP-Seq_THP-1_Human1.13279573
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13128450
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12939217
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12395605
114* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11719033
115RUNX_20019798_ChIP-Seq_JUKART_Human1.11164310
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11134158
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09144610
118* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07772493
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.07730237
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07328253
121FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05520106
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03246880
123RXR_22158963_ChIP-Seq_LIVER_Mouse1.02610886
124PU_27001747_Chip-Seq_BMDM_Mouse1.01975751
125* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01818324
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01629973
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00507715
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00492163
129* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00274868
130* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99457613
131SPI1_23127762_ChIP-Seq_K562_Human0.99361173
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98668877
133P300_27268052_Chip-Seq_Bcells_Human0.92430688
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91876258
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87140174
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86676583
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84096325
138CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84034260
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82782634
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81459898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system2.73115366
2MP0001835_abnormal_antigen_presentation2.68468763
3MP0002396_abnormal_hematopoietic_system2.64889703
4MP0003763_abnormal_thymus_physiology2.58928105
5MP0003724_increased_susceptibility_to2.48900914
6MP0005671_abnormal_response_to2.41199721
7MP0006054_spinal_hemorrhage2.34527396
8MP0003436_decreased_susceptibility_to2.29021748
9MP0009785_altered_susceptibility_to2.21950447
10MP0008004_abnormal_stomach_pH2.17812676
11MP0009333_abnormal_splenocyte_physiolog2.05558863
12MP0005464_abnormal_platelet_physiology1.99194923
13MP0001800_abnormal_humoral_immune1.98886446
14MP0005000_abnormal_immune_tolerance1.97273304
15MP0005397_hematopoietic_system_phenotyp1.95597567
16MP0001545_abnormal_hematopoietic_system1.95597567
17MP0005025_abnormal_response_to1.95386098
18MP0002723_abnormal_immune_serum1.90471084
19MP0002420_abnormal_adaptive_immunity1.89009885
20MP0002398_abnormal_bone_marrow1.88789346
21MP0002452_abnormal_antigen_presenting1.86903739
22MP0001819_abnormal_immune_cell1.86567522
23MP0004808_abnormal_hematopoietic_stem1.82138170
24MP0005387_immune_system_phenotype1.78450014
25MP0001790_abnormal_immune_system1.78450014
26MP0002166_altered_tumor_susceptibility1.77174813
27MP0002419_abnormal_innate_immunity1.76136882
28MP0002405_respiratory_system_inflammati1.74072570
29MP0005058_abnormal_lysosome_morphology1.73674348
30MP0000689_abnormal_spleen_morphology1.72601592
31MP0002722_abnormal_immune_system1.68523676
32MP0009840_abnormal_foam_cell1.67604307
33MP0000716_abnormal_immune_system1.64858165
34MP0003191_abnormal_cellular_cholesterol1.64836519
35MP0010368_abnormal_lymphatic_system1.64176008
36MP0002148_abnormal_hypersensitivity_rea1.60181356
37MP0003300_gastrointestinal_ulcer1.57723489
38MP0003693_abnormal_embryo_hatching1.56418328
39MP0010155_abnormal_intestine_physiology1.55148231
40MP0002429_abnormal_blood_cell1.54482372
41MP0000490_abnormal_crypts_of1.53979257
42MP0003279_aneurysm1.51818161
43MP0001853_heart_inflammation1.51463447
44MP0006082_CNS_inflammation1.51277893
45MP0001845_abnormal_inflammatory_respons1.48826722
46MP0000858_altered_metastatic_potential1.48159794
47MP0005023_abnormal_wound_healing1.47339290
48MP0002877_abnormal_melanocyte_morpholog1.45871586
49MP0001533_abnormal_skeleton_physiology1.44546805
50MP0003075_altered_response_to1.43519985
51MP0008469_abnormal_protein_level1.43232626
52MP0000465_gastrointestinal_hemorrhage1.42200149
53MP0008438_abnormal_cutaneous_collagen1.41521051
54MP0003303_peritoneal_inflammation1.40655283
55MP0002933_joint_inflammation1.40312641
56MP0001873_stomach_inflammation1.40267754
57MP0000703_abnormal_thymus_morphology1.39063087
58MP0003806_abnormal_nucleotide_metabolis1.37110984
59MP0000343_altered_response_to1.33933832
60MP0004947_skin_inflammation1.32782383
61MP0003172_abnormal_lysosome_physiology1.31920300
62MP0001851_eye_inflammation1.26777109
63MP0002139_abnormal_hepatobiliary_system1.25041465
64MP0010352_gastrointestinal_tract_polyps1.23699962
65MP0003566_abnormal_cell_adhesion1.22979536
66MP0003186_abnormal_redox_activity1.22346599
67MP0005083_abnormal_biliary_tract1.21575378
68MP0009278_abnormal_bone_marrow1.20345479
69MP0003656_abnormal_erythrocyte_physiolo1.17480796
70MP0002006_tumorigenesis1.16119650
71MP0003866_abnormal_defecation1.11437918
72MP0008007_abnormal_cellular_replicative1.09688092
73MP0002019_abnormal_tumor_incidence1.07034005
74MP0001663_abnormal_digestive_system1.06211007
75MP0003828_pulmonary_edema1.03344914
76MP0004957_abnormal_blastocyst_morpholog1.02089524
77MP0003195_calcinosis1.02072685
78MP0005075_abnormal_melanosome_morpholog1.01251116
79MP0005365_abnormal_bile_salt1.00456938
80MP0000609_abnormal_liver_physiology0.97969526
81MP0003705_abnormal_hypodermis_morpholog0.97370127
82MP0000598_abnormal_liver_morphology0.95657533
83MP0005167_abnormal_blood-brain_barrier0.95403353
84MP0009763_increased_sensitivity_to0.94875633
85MP0005166_decreased_susceptibility_to0.94729246
86MP0004130_abnormal_muscle_cell0.92974029
87MP0005319_abnormal_enzyme/_coenzyme0.92291711
88MP0009643_abnormal_urine_homeostasis0.91307118
89MP0005220_abnormal_exocrine_pancreas0.89289006
90MP0004883_abnormal_blood_vessel0.87749007
91MP0003077_abnormal_cell_cycle0.86801575
92MP0009765_abnormal_xenobiotic_induced0.86608597
93MP0001243_abnormal_dermal_layer0.86557716
94MP0008260_abnormal_autophagy0.84669462
95MP0001879_abnormal_lymphatic_vessel0.84507852
96MP0001542_abnormal_bone_strength0.84178955
97MP0005085_abnormal_gallbladder_physiolo0.82078459
98MP0001986_abnormal_taste_sensitivity0.82001665
99MP0002693_abnormal_pancreas_physiology0.81182051
100MP0000249_abnormal_blood_vessel0.81093836
101MP0005310_abnormal_salivary_gland0.80192832
102MP0010329_abnormal_lipoprotein_level0.79201286
103MP0005390_skeleton_phenotype0.79034033
104MP0002138_abnormal_hepatobiliary_system0.78764032
105MP0005164_abnormal_response_to0.78278861
106MP0000013_abnormal_adipose_tissue0.78278007
107MP0002132_abnormal_respiratory_system0.77694819
108MP0003795_abnormal_bone_structure0.77552793
109MP0001958_emphysema0.77153464
110MP0002998_abnormal_bone_remodeling0.76806126
111MP0005084_abnormal_gallbladder_morpholo0.76144239
112MP0000358_abnormal_cell_content/0.75948713
113MP0005451_abnormal_body_composition0.75048035
114MP0003448_altered_tumor_morphology0.73113790
115MP0003183_abnormal_peptide_metabolism0.72414354
116MP0008875_abnormal_xenobiotic_pharmacok0.72393120
117MP0006036_abnormal_mitochondrial_physio0.72098443
118MP0005670_abnormal_white_adipose0.71882672
119MP0000604_amyloidosis0.71351874
120MP0000477_abnormal_intestine_morphology0.70938128
121MP0005165_increased_susceptibility_to0.70590979
122MP0009764_decreased_sensitivity_to0.70362018
123MP0004510_myositis0.69948081
124MP0000230_abnormal_systemic_arterial0.67154222
125MP0008874_decreased_physiological_sensi0.66890404
126MP0003638_abnormal_response/metabolism_0.66609163
127MP0003045_fibrosis0.65821897
128MP0002118_abnormal_lipid_homeostasis0.65022501

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)4.63656083
2Menorrhagia (HP:0000132)4.58605599
3Increased mean platelet volume (HP:0011877)4.39552351
4Stomatitis (HP:0010280)4.35412497
5Increased IgM level (HP:0003496)4.23435851
6Elevated erythrocyte sedimentation rate (HP:0003565)4.03283700
7Abnormality of the nasal mucosa (HP:0000433)3.81535271
8Chronic obstructive pulmonary disease (HP:0006510)3.73864952
9Obstructive lung disease (HP:0006536)3.73864952
10Thrombocytosis (HP:0001894)3.72493444
11IgM deficiency (HP:0002850)3.70922971
12Encephalitis (HP:0002383)3.52779747
13Recurrent gram-negative bacterial infections (HP:0005420)3.46492122
14Spontaneous hematomas (HP:0007420)3.41934046
15Autoimmune hemolytic anemia (HP:0001890)3.40046680
16Retrobulbar optic neuritis (HP:0100654)3.23119275
17Optic neuritis (HP:0100653)3.23119275
18Hyperlipoproteinemia (HP:0010980)3.19923303
19Petechiae (HP:0000967)3.16794936
20Myositis (HP:0100614)3.13538004
21Abnormality of iron homeostasis (HP:0011031)3.12551581
22Abnormality of T cell physiology (HP:0011840)3.03443916
23Chronic otitis media (HP:0000389)3.02375063
24Vacuolated lymphocytes (HP:0001922)2.93129099
25Mediastinal lymphadenopathy (HP:0100721)2.92962890
26Nasal polyposis (HP:0100582)2.91342995
27Abnormality of liposaccharide metabolism (HP:0010968)2.87126424
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.87126424
29Abnormality of glycolipid metabolism (HP:0010969)2.87126424
30Recurrent bronchitis (HP:0002837)2.86774722
31Leukocytosis (HP:0001974)2.86359768
32Abnormal number of erythroid precursors (HP:0012131)2.83293268
33Abnormality of transition element cation homeostasis (HP:0011030)2.81439360
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.79844184
35Protrusio acetabuli (HP:0003179)2.79347239
36Aplastic anemia (HP:0001915)2.78177467
37Abnormality of cells of the erythroid lineage (HP:0012130)2.78003049
38Reduced antithrombin III activity (HP:0001976)2.76985171
39Epistaxis (HP:0000421)2.73127599
40Abnormality of T cells (HP:0002843)2.72064056
41Eczematoid dermatitis (HP:0000976)2.68277750
42Prolonged bleeding time (HP:0003010)2.65059511
43Hypochromic anemia (HP:0001931)2.64011607
44Granulocytopenia (HP:0001913)2.57251710
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55634056
46Abnormal protein N-linked glycosylation (HP:0012347)2.55634056
47Abnormal protein glycosylation (HP:0012346)2.55634056
48Abnormal glycosylation (HP:0012345)2.55634056
49Urticaria (HP:0001025)2.54048197
50Systemic lupus erythematosus (HP:0002725)2.53729286
51Chest pain (HP:0100749)2.52628833
52Hematochezia (HP:0002573)2.51453737
53Type I transferrin isoform profile (HP:0003642)2.48107431
54Gastrointestinal infarctions (HP:0005244)2.47635907
55Dysostosis multiplex (HP:0000943)2.47605678
56Microcytic anemia (HP:0001935)2.47524041
57Eosinophilia (HP:0001880)2.47385636
58Vertebral compression fractures (HP:0002953)2.46512777
59Polycythemia (HP:0001901)2.45198953
60Recurrent viral infections (HP:0004429)2.45040734
61Recurrent abscess formation (HP:0002722)2.44321268
62Pulmonary embolism (HP:0002204)2.41749019
63Gastrointestinal inflammation (HP:0004386)2.39618005
64Agammaglobulinemia (HP:0004432)2.39514303
65Abnormal platelet function (HP:0011869)2.38445935
66Impaired platelet aggregation (HP:0003540)2.38445935
67Hepatosplenomegaly (HP:0001433)2.34665720
68Nonimmune hydrops fetalis (HP:0001790)2.34507419
69Joint stiffness (HP:0001387)2.34431544
70Mucopolysacchariduria (HP:0008155)2.32083105
71Urinary glycosaminoglycan excretion (HP:0003541)2.32083105
72Hypochromic microcytic anemia (HP:0004840)2.27619351
73Recurrent fungal infections (HP:0002841)2.27560263
74Microretrognathia (HP:0000308)2.26943466
75Anorexia (HP:0002039)2.26648822
76Inflammation of the large intestine (HP:0002037)2.26333999
77Keratoconjunctivitis sicca (HP:0001097)2.25651202
78Pulmonary infiltrates (HP:0002113)2.24940860
79Poikilocytosis (HP:0004447)2.24660679
80Thrombophlebitis (HP:0004418)2.21732215
81Cellulitis (HP:0100658)2.21546708
82Joint hemorrhage (HP:0005261)2.21152070
83Hypergammaglobulinemia (HP:0010702)2.21128476
84Beaking of vertebral bodies (HP:0004568)2.21033934
85Pustule (HP:0200039)2.20526267
86Episodic fever (HP:0001954)2.19863717
87Abnormality of the prostate (HP:0008775)2.19716430
88T lymphocytopenia (HP:0005403)2.18752628
89Reticulocytopenia (HP:0001896)2.17798917
90Cervical subluxation (HP:0003308)2.16102196
91Vertigo (HP:0002321)2.14282892
92Abnormality of eosinophils (HP:0001879)2.14274532
93Abnormality of T cell number (HP:0011839)2.13536575
94Interstitial pulmonary disease (HP:0006530)2.12919200
95Joint swelling (HP:0001386)2.11105326
96Panhypogammaglobulinemia (HP:0003139)2.10704471
97Keratoconjunctivitis (HP:0001096)2.09458277
98Colitis (HP:0002583)2.09304438
99Bruising susceptibility (HP:0000978)2.08492547
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07547338
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07547338
102Abnormality of polysaccharide metabolism (HP:0011012)2.06166620
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06166620
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06166620
105Orchitis (HP:0100796)2.05430390
106Hypertensive crisis (HP:0100735)2.04885714
107Hypoproteinemia (HP:0003075)2.03945870
108Acute hepatic failure (HP:0006554)2.02453728
109Abnormality of cells of the lymphoid lineage (HP:0012140)2.01209829
110Hypoglycemic coma (HP:0001325)2.00944802
111Lymphopenia (HP:0001888)1.99528899
112Increased neuronal autofluorescent lipopigment (HP:0002074)1.98767567
113Generalized aminoaciduria (HP:0002909)1.98432897
114Myocardial infarction (HP:0001658)1.97549705
115Purpura (HP:0000979)1.96550661
116Increased serum ferritin (HP:0003281)1.95718357
117Pallor (HP:0000980)1.93990978
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93632796
119Paralysis (HP:0003470)1.93579962
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.92540524
121Hypertriglyceridemia (HP:0002155)1.90742933
122Entropion (HP:0000621)1.90711443
123Autoimmune thrombocytopenia (HP:0001973)1.90072081
124Increased cerebral lipofuscin (HP:0011813)1.89671425
125Abnormality of macrophages (HP:0004311)1.89469616
126Gingivitis (HP:0000230)1.88794158
127Abnormality of the intrinsic pathway (HP:0010989)1.88539512
128Recurrent bacterial skin infections (HP:0005406)1.87777334
129Gangrene (HP:0100758)1.87117310
130Recurrent cutaneous fungal infections (HP:0011370)1.86341333
131Chronic mucocutaneous candidiasis (HP:0002728)1.86341333
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85607103
133Biconcave vertebral bodies (HP:0004586)1.85295169
134Recurrent skin infections (HP:0001581)1.84097231
135Cerebral aneurysm (HP:0004944)1.83601840
136Fatigue (HP:0012378)1.83573559
137Meningitis (HP:0001287)1.81245215
138IgG deficiency (HP:0004315)1.79804895
139Emphysema (HP:0002097)1.78464605
140Hemoptysis (HP:0002105)1.77743206
141Reduced subcutaneous adipose tissue (HP:0003758)1.75390559
142Broad face (HP:0000283)1.75150601
143Multiple enchondromatosis (HP:0005701)1.74946534
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74777636
145Late onset (HP:0003584)1.74594297
146Abnormality of the common coagulation pathway (HP:0010990)1.73539519
147Gingival bleeding (HP:0000225)1.70052732
148Thoracic kyphosis (HP:0002942)1.68261465
149Poikiloderma (HP:0001029)1.67391824
150Vasculitis (HP:0002633)1.67286683
151Progressive neurologic deterioration (HP:0002344)1.66664054
152Arterial thrombosis (HP:0004420)1.66485659
153Increased IgE level (HP:0003212)1.66430017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.58142591
2ERN13.38225707
3TGFBR23.34534929
4KDR3.34237168
5MAP4K13.32287707
6TLK13.26821894
7NME23.23512817
8FES2.93162102
9TGFBR12.66234537
10ZAP702.37759077
11FLT32.09018753
12JAK32.08767072
13KIT1.96549749
14MAP2K31.95269986
15TRIB31.93200599
16TBK11.87877458
17RPS6KA41.83975518
18PIM21.83948977
19TIE11.80957813
20TXK1.79018911
21EEF2K1.74325158
22TYK21.72966372
23STK161.72141102
24TESK21.69037326
25TEC1.67415548
26BTK1.64702699
27PKN21.64527689
28BCKDK1.64412878
29LRRK21.60653143
30TAOK21.59663533
31BUB11.58775865
32ZAK1.56882848
33MAPKAPK31.52399303
34SCYL21.51064286
35STK101.50942500
36FGFR41.48181308
37IKBKE1.43224382
38BLK1.41770025
39MAP3K111.40061160
40BMX1.35940197
41CSF1R1.33416326
42PASK1.32854270
43MAP3K131.26904809
44ITK1.25386041
45BMPR21.23143257
46PRPF4B1.23071376
47GRK61.17856859
48MAP3K31.14928001
49FGR1.13040699
50MAP3K101.11797803
51IRAK31.11540910
52ACVR1B1.07329043
53EIF2AK31.05211331
54MARK31.04251791
55PAK41.03500227
56PRKCQ1.01569130
57MAPK151.00572970
58GRK70.97525473
59NLK0.96575090
60SYK0.95099455
61JAK10.92580062
62MAP3K10.90896025
63LCK0.90075825
64MAPK120.89394313
65MAP3K50.88830148
66IKBKB0.88505325
67MST40.87791585
68TAOK30.87086735
69RPS6KB20.86999887
70CSK0.86426202
71PTK2B0.86339537
72EIF2AK10.85665652
73PIM10.83655892
74TTN0.81368055
75WEE10.81053745
76MAP3K60.80854531
77IRAK40.80052588
78TESK10.77504599
79LYN0.74893237
80PRKG20.74412339
81HCK0.73426101
82MUSK0.72951893
83DYRK30.69636825
84MAP3K140.68405543
85PDK10.67573653
86MAP3K80.65130233
87PINK10.64539548
88CAMKK20.62028888
89PIK3CG0.61879867
90IRAK10.61713354
91VRK10.61389374
92CDK40.60008152
93NEK20.58504369
94PAK10.58411420
95BRSK20.56712707
96CDK70.56564335
97EPHB10.55897569
98MATK0.55671006
99JAK20.54651725
100HIPK20.52953127
101PTK60.50587638
102MOS0.49730056
103NUAK10.48267653
104RAF10.48239680
105ILK0.47954666
106MAP3K120.47176602
107MYLK0.46720541
108ADRBK10.46517225
109STK40.45553646
110ARAF0.44434370
111MAPK110.43961122
112CDK190.42930318
113GRK50.41017807
114MAP2K60.40876100
115EPHA20.39404662
116ADRBK20.38270482
117ABL10.38239441
118RIPK10.38237879
119FYN0.37946057
120PRKCD0.37884432
121MAP2K20.37123843
122SIK30.37102849
123IGF1R0.36202823
124MAPKAPK20.35405965
125CHUK0.35229503
126STK240.35149031
127RPS6KA60.34900050
128TRPM70.34782726
129PTK20.34572592
130TAOK10.33655089
131PDPK10.33402275
132PAK20.33033520
133TNK20.31004505
134RPS6KA50.29787302
135TSSK60.29460674
136SIK10.29447089
137MAPK70.29271703
138INSR0.27784690
139RET0.27458209
140PIK3CA0.21751502
141PRKD10.21667866
142PRKACG0.21299333

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.69127186
2Ribosome_Homo sapiens_hsa030103.19593025
3Autoimmune thyroid disease_Homo sapiens_hsa053203.03512065
4DNA replication_Homo sapiens_hsa030302.82689161
5Primary immunodeficiency_Homo sapiens_hsa053402.66550762
6Protein export_Homo sapiens_hsa030602.35864123
7Antigen processing and presentation_Homo sapiens_hsa046122.27350123
8Type I diabetes mellitus_Homo sapiens_hsa049402.11993500
9Other glycan degradation_Homo sapiens_hsa005112.06149046
10Asthma_Homo sapiens_hsa053102.03648414
11Proteasome_Homo sapiens_hsa030501.92175659
12Base excision repair_Homo sapiens_hsa034101.85802930
13Folate biosynthesis_Homo sapiens_hsa007901.84016432
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.78314769
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74450726
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71323475
17Mismatch repair_Homo sapiens_hsa034301.63825070
18Measles_Homo sapiens_hsa051621.62139337
19Leishmaniasis_Homo sapiens_hsa051401.62018372
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56108847
21Pyrimidine metabolism_Homo sapiens_hsa002401.55384346
22Rheumatoid arthritis_Homo sapiens_hsa053231.54852340
23Sulfur relay system_Homo sapiens_hsa041221.54098357
24Shigellosis_Homo sapiens_hsa051311.51223698
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51105945
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50345686
27Hematopoietic cell lineage_Homo sapiens_hsa046401.49138591
28Legionellosis_Homo sapiens_hsa051341.48673906
29N-Glycan biosynthesis_Homo sapiens_hsa005101.47702280
30Staphylococcus aureus infection_Homo sapiens_hsa051501.45808992
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.45262996
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41190761
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.39006525
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38850786
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37486175
36Arachidonic acid metabolism_Homo sapiens_hsa005901.35096940
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34784678
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30208100
39Chemokine signaling pathway_Homo sapiens_hsa040621.29598425
40B cell receptor signaling pathway_Homo sapiens_hsa046621.29505879
41Selenocompound metabolism_Homo sapiens_hsa004501.27362572
42Osteoclast differentiation_Homo sapiens_hsa043801.25118486
43Nucleotide excision repair_Homo sapiens_hsa034201.21409779
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18244341
45Herpes simplex infection_Homo sapiens_hsa051681.17541677
46Phagosome_Homo sapiens_hsa041451.16143930
47Caffeine metabolism_Homo sapiens_hsa002321.15193953
48Spliceosome_Homo sapiens_hsa030401.14688158
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14048579
50Acute myeloid leukemia_Homo sapiens_hsa052211.13730265
51African trypanosomiasis_Homo sapiens_hsa051431.11085367
52Lysosome_Homo sapiens_hsa041421.10806000
53Pentose phosphate pathway_Homo sapiens_hsa000301.10096547
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.08168378
55Apoptosis_Homo sapiens_hsa042101.07005070
56p53 signaling pathway_Homo sapiens_hsa041151.06657358
57Galactose metabolism_Homo sapiens_hsa000521.05394937
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.99433253
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.98719082
60One carbon pool by folate_Homo sapiens_hsa006700.97776195
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95495697
62Linoleic acid metabolism_Homo sapiens_hsa005910.95438506
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95041684
64Malaria_Homo sapiens_hsa051440.94432377
65T cell receptor signaling pathway_Homo sapiens_hsa046600.94340502
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.93610979
67Platelet activation_Homo sapiens_hsa046110.93608942
68Pertussis_Homo sapiens_hsa051330.93236559
69RNA polymerase_Homo sapiens_hsa030200.93205818
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89190214
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88785970
72Hepatitis B_Homo sapiens_hsa051610.88227120
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86785842
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86018498
75Toxoplasmosis_Homo sapiens_hsa051450.85938307
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84999551
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84017988
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82592551
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81965382
80Influenza A_Homo sapiens_hsa051640.80363605
81Epstein-Barr virus infection_Homo sapiens_hsa051690.77503031
82Complement and coagulation cascades_Homo sapiens_hsa046100.75619727
83RNA transport_Homo sapiens_hsa030130.74014879
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73567599
85Homologous recombination_Homo sapiens_hsa034400.73344479
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72514334
87TNF signaling pathway_Homo sapiens_hsa046680.69936794
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69227552
89HTLV-I infection_Homo sapiens_hsa051660.68758029
90Viral myocarditis_Homo sapiens_hsa054160.65513794
91Viral carcinogenesis_Homo sapiens_hsa052030.64785963
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64101661
93Glycerolipid metabolism_Homo sapiens_hsa005610.63669980
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63390230
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61853335
96Chronic myeloid leukemia_Homo sapiens_hsa052200.61009580
97Collecting duct acid secretion_Homo sapiens_hsa049660.57987869
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.57974873
99Tuberculosis_Homo sapiens_hsa051520.57958108
100RNA degradation_Homo sapiens_hsa030180.57215436
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57008266
102Thyroid cancer_Homo sapiens_hsa052160.56878723
103Pancreatic secretion_Homo sapiens_hsa049720.56351931
104Fat digestion and absorption_Homo sapiens_hsa049750.53621696
105Endocytosis_Homo sapiens_hsa041440.51783303
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49827093
107Purine metabolism_Homo sapiens_hsa002300.49802626
108Nitrogen metabolism_Homo sapiens_hsa009100.49431274
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48701566
110Cell cycle_Homo sapiens_hsa041100.48025507
111Salmonella infection_Homo sapiens_hsa051320.47189144
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46748900
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46727300
114Small cell lung cancer_Homo sapiens_hsa052220.46387195
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45989469
116Retinol metabolism_Homo sapiens_hsa008300.45425799
117Chemical carcinogenesis_Homo sapiens_hsa052040.43807607
118Pancreatic cancer_Homo sapiens_hsa052120.41113625
119Biosynthesis of amino acids_Homo sapiens_hsa012300.40860587
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40506199
121Glutathione metabolism_Homo sapiens_hsa004800.40456063
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40361298
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.40158847
124Carbon metabolism_Homo sapiens_hsa012000.39551752
125Fatty acid elongation_Homo sapiens_hsa000620.39414149
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39284897
127Allograft rejection_Homo sapiens_hsa053300.39181819
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39178592
129Systemic lupus erythematosus_Homo sapiens_hsa053220.38733196
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.37913759
131Fatty acid degradation_Homo sapiens_hsa000710.35548782
132ABC transporters_Homo sapiens_hsa020100.35330162
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34944621
134Hepatitis C_Homo sapiens_hsa051600.34874019
135Amoebiasis_Homo sapiens_hsa051460.31446812
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.22936061
137Peroxisome_Homo sapiens_hsa041460.21453793
138PPAR signaling pathway_Homo sapiens_hsa033200.20745253
139Starch and sucrose metabolism_Homo sapiens_hsa005000.20227299

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