TPT1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to nicotine (GO:0071316)9.30423168
2epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)8.85727578
3eye photoreceptor cell differentiation (GO:0001754)8.28252747
4photoreceptor cell differentiation (GO:0046530)8.28252747
5positive regulation of meiosis (GO:0045836)6.55276400
6cartilage morphogenesis (GO:0060536)6.48455763
7negative regulation of transcription regulatory region DNA binding (GO:2000678)6.38073366
8positive regulation of meiotic cell cycle (GO:0051446)6.12402546
9regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901215.77997503
10regulation of mesenchymal cell apoptotic process (GO:2001053)5.63690738
11positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.43051616
12mesenchymal cell proliferation (GO:0010463)5.29456172
13pituitary gland development (GO:0021983)4.94873113
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.61837573
15regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.36182997
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24369593
17viral transcription (GO:0019083)4.22253142
18positive regulation of BMP signaling pathway (GO:0030513)4.18654345
19opioid receptor signaling pathway (GO:0038003)4.14690223
20translational termination (GO:0006415)4.12745605
21nonmotile primary cilium assembly (GO:0035058)4.07357133
22positive regulation of signal transduction by p53 class mediator (GO:1901798)4.05280639
23regulation of transcription regulatory region DNA binding (GO:2000677)4.00884962
24respiratory chain complex IV assembly (GO:0008535)3.99814474
25organelle disassembly (GO:1903008)3.96183092
26middle ear morphogenesis (GO:0042474)3.86601613
27protein complex biogenesis (GO:0070271)3.83707881
28axonemal dynein complex assembly (GO:0070286)3.82478304
29cardiac epithelial to mesenchymal transition (GO:0060317)3.80489774
30signal transduction involved in regulation of gene expression (GO:0023019)3.77903765
31sequestering of actin monomers (GO:0042989)3.73233323
32negative regulation of Ras GTPase activity (GO:0034261)3.72270312
33platelet dense granule organization (GO:0060155)3.68927700
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66436624
35epithelial cilium movement (GO:0003351)3.64713043
36cytochrome complex assembly (GO:0017004)3.62951589
37positive regulation of growth hormone secretion (GO:0060124)3.58060996
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57331799
39ribonucleoprotein complex disassembly (GO:0032988)3.55540754
40respiratory electron transport chain (GO:0022904)3.55177733
41ribosomal small subunit assembly (GO:0000028)3.55167643
42protein neddylation (GO:0045116)3.54621638
43maturation of SSU-rRNA (GO:0030490)3.50656336
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50390608
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.50390608
46NADH dehydrogenase complex assembly (GO:0010257)3.50390608
47cotranslational protein targeting to membrane (GO:0006613)3.49914552
48electron transport chain (GO:0022900)3.48830984
49protein polyglutamylation (GO:0018095)3.47622051
50protein targeting to ER (GO:0045047)3.46331443
51DNA damage response, detection of DNA damage (GO:0042769)3.44382687
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39320050
53behavioral response to nicotine (GO:0035095)3.39271105
54cell surface receptor signaling pathway involved in heart development (GO:0061311)3.37572830
55translational elongation (GO:0006414)3.36074677
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34003418
57ATP synthesis coupled proton transport (GO:0015986)3.34003418
58mitochondrial respiratory chain complex assembly (GO:0033108)3.29641404
59postsynaptic membrane organization (GO:0001941)3.27151062
60ribosomal small subunit biogenesis (GO:0042274)3.24529110
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.23463351
62protein localization to endoplasmic reticulum (GO:0070972)3.18066754
63response to gravity (GO:0009629)3.15955503
64cellular protein complex disassembly (GO:0043624)3.13487675
65cilium movement (GO:0003341)3.10042768
66negative regulation of DNA binding (GO:0043392)3.08337651
67midbrain development (GO:0030901)3.07523241
68regulation of growth hormone secretion (GO:0060123)3.05616597
69viral life cycle (GO:0019058)3.03862100
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02004046
71cellular response to vitamin D (GO:0071305)3.00018560
72embryonic hindlimb morphogenesis (GO:0035116)2.99253204
73spinal cord association neuron differentiation (GO:0021527)2.93730678
74replication fork processing (GO:0031297)2.89259273
75ribosomal large subunit biogenesis (GO:0042273)2.85367487
76regulation of cellular respiration (GO:0043457)2.85064413
77neuron fate determination (GO:0048664)2.82741874
78hindlimb morphogenesis (GO:0035137)2.81953272
79regulation of odontogenesis (GO:0042481)2.79234250
80retina layer formation (GO:0010842)2.78847963
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77519049
82cilium morphogenesis (GO:0060271)2.76318798
83response to nicotine (GO:0035094)2.73021482
84brain morphogenesis (GO:0048854)2.72162299
85regulation of cilium movement (GO:0003352)2.71883514
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71152445
87resolution of meiotic recombination intermediates (GO:0000712)2.70243911
88sperm motility (GO:0030317)2.69414542
89macromolecular complex disassembly (GO:0032984)2.69158958
90vasculature development (GO:0001944)2.67165120
91negative regulation of response to food (GO:0032096)2.66044104
92negative regulation of appetite (GO:0032099)2.66044104
93translational initiation (GO:0006413)2.62923742
94protein complex disassembly (GO:0043241)2.62564928
95sulfate transmembrane transport (GO:1902358)2.61174713
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59338679
97striatum development (GO:0021756)2.57281181
98righting reflex (GO:0060013)2.53822747
99cell wall macromolecule catabolic process (GO:0016998)14.9212367
100cell wall macromolecule metabolic process (GO:0044036)12.4696615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61867214
2IGF1R_20145208_ChIP-Seq_DFB_Human4.10212777
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.09586761
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.03676326
5VDR_22108803_ChIP-Seq_LS180_Human3.63459577
6CBX2_27304074_Chip-Seq_ESCs_Mouse3.18696748
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92611838
8RNF2_27304074_Chip-Seq_NSC_Mouse2.66936131
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.64120080
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31613858
11ZNF274_21170338_ChIP-Seq_K562_Hela2.29778909
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.25737693
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23848813
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22991574
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21742623
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09578395
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.03401995
18FUS_26573619_Chip-Seq_HEK293_Human2.00237419
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98865557
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.96566850
21GBX2_23144817_ChIP-Seq_PC3_Human1.84744265
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82893447
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82893447
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.74795042
25EWS_26573619_Chip-Seq_HEK293_Human1.73420496
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73355922
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73355922
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69992827
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69904503
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.59801832
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.56688636
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53984893
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52463096
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51919873
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51033457
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50334573
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49958790
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49662981
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46216335
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.45915682
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44091893
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.41312898
43P300_19829295_ChIP-Seq_ESCs_Human1.40022624
44TAF15_26573619_Chip-Seq_HEK293_Human1.37785065
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.36213802
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35559670
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30911681
48REST_21632747_ChIP-Seq_MESCs_Mouse1.29894130
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29757048
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.29268417
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28886378
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.28290357
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28121922
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25498524
55TCF4_22108803_ChIP-Seq_LS180_Human1.24106345
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19973391
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18543178
58BCAT_22108803_ChIP-Seq_LS180_Human1.17611672
59STAT3_23295773_ChIP-Seq_U87_Human1.17473536
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16846309
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.16510316
62MYC_18940864_ChIP-ChIP_HL60_Human1.15461930
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14576227
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13777313
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12643637
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.12641042
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12561907
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11826438
69SMAD4_21799915_ChIP-Seq_A2780_Human1.09584543
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07811391
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07089816
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06813002
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06456858
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.03081096
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00849630
76IRF1_19129219_ChIP-ChIP_H3396_Human1.00418146
77SMAD3_21741376_ChIP-Seq_EPCs_Human0.99886255
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99857984
79TP53_20018659_ChIP-ChIP_R1E_Mouse0.99128676
80KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97777846
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.97409457
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.97297231
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96452269
84SMAD4_21741376_ChIP-Seq_EPCs_Human0.96220122
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94895726
86P53_22387025_ChIP-Seq_ESCs_Mouse0.94892466
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.94197460
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94172216
89RUNX2_22187159_ChIP-Seq_PCA_Human0.91291636
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91185943
91TCF4_23295773_ChIP-Seq_U87_Human0.91090094
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.91019414
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90258129
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89497611
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.89437588
96WDR5_24793694_ChIP-Seq_LNCAP_Human0.89347155
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.88898594
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87624802
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86309994
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85627363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.80092960
2MP0009379_abnormal_foot_pigmentation4.00390038
3MP0001968_abnormal_touch/_nociception3.53213659
4MP0002736_abnormal_nociception_after2.60131426
5MP0001188_hyperpigmentation2.55490531
6MP0006292_abnormal_olfactory_placode2.50874310
7MP0000049_abnormal_middle_ear2.37044298
8MP0004142_abnormal_muscle_tone2.33610948
9MP0005551_abnormal_eye_electrophysiolog2.23578331
10MP0002735_abnormal_chemical_nociception2.20732504
11MP0001293_anophthalmia2.19710928
12MP0004145_abnormal_muscle_electrophysio2.13476736
13MP0002734_abnormal_mechanical_nocicepti2.08723404
14MP0000372_irregular_coat_pigmentation2.02027819
15MP0000631_abnormal_neuroendocrine_gland1.98513121
16MP0000778_abnormal_nervous_system1.94588464
17MP0002163_abnormal_gland_morphology1.88887065
18MP0005174_abnormal_tail_pigmentation1.78001595
19MP0003879_abnormal_hair_cell1.76532350
20MP0003122_maternal_imprinting1.74070513
21MP0001486_abnormal_startle_reflex1.73445808
22MP0006276_abnormal_autonomic_nervous1.70274669
23MP0002234_abnormal_pharynx_morphology1.69060309
24MP0008877_abnormal_DNA_methylation1.67919771
25MP0003890_abnormal_embryonic-extraembry1.62991290
26MP0005646_abnormal_pituitary_gland1.60605711
27MP0002928_abnormal_bile_duct1.59877397
28MP0000569_abnormal_digit_pigmentation1.58951103
29MP0005670_abnormal_white_adipose1.58715688
30MP0004742_abnormal_vestibular_system1.58589173
31MP0003787_abnormal_imprinting1.57934951
32MP0003937_abnormal_limbs/digits/tail_de1.52736765
33MP0004381_abnormal_hair_follicle1.52037749
34MP0002272_abnormal_nervous_system1.50743740
35MP0005499_abnormal_olfactory_system1.50083739
36MP0005394_taste/olfaction_phenotype1.50083739
37MP0002837_dystrophic_cardiac_calcinosis1.49623883
38MP0005423_abnormal_somatic_nervous1.46252991
39MP0002177_abnormal_outer_ear1.45511474
40MP0002938_white_spotting1.44233159
41MP0001984_abnormal_olfaction1.43991424
42MP0002184_abnormal_innervation1.40681005
43MP0004019_abnormal_vitamin_homeostasis1.38095700
44MP0009250_abnormal_appendicular_skeleto1.38022946
45MP0001440_abnormal_grooming_behavior1.36938407
46MP0002697_abnormal_eye_size1.35234700
47MP0003880_abnormal_central_pattern1.33236708
48MP0005379_endocrine/exocrine_gland_phen1.32059352
49MP0001970_abnormal_pain_threshold1.30648570
50MP0001286_abnormal_eye_development1.29972327
51MP0005195_abnormal_posterior_eye1.25688074
52MP0003755_abnormal_palate_morphology1.24357392
53MP0000955_abnormal_spinal_cord1.21988497
54MP0001986_abnormal_taste_sensitivity1.18400017
55MP0001542_abnormal_bone_strength1.18209971
56MP0008995_early_reproductive_senescence1.17894881
57MP0004885_abnormal_endolymph1.17684398
58MP0004043_abnormal_pH_regulation1.16075897
59MP0002638_abnormal_pupillary_reflex1.14438323
60MP0006072_abnormal_retinal_apoptosis1.13563685
61MP0002067_abnormal_sensory_capabilities1.12736153
62MP0002733_abnormal_thermal_nociception1.11732494
63MP0009745_abnormal_behavioral_response1.11723070
64MP0001963_abnormal_hearing_physiology1.11547338
65MP0002752_abnormal_somatic_nervous1.09638713
66MP0003385_abnormal_body_wall1.07706984
67MP0005171_absent_coat_pigmentation1.07524879
68MP0008789_abnormal_olfactory_epithelium1.06989626
69MP0005410_abnormal_fertilization1.00221574
70MP0001905_abnormal_dopamine_level0.98259462
71MP0001485_abnormal_pinna_reflex0.98227344
72MP0004270_analgesia0.96151802
73MP0003646_muscle_fatigue0.95407206
74MP0000427_abnormal_hair_cycle0.94473269
75MP0009046_muscle_twitch0.94327009
76MP0002572_abnormal_emotion/affect_behav0.92969397
77MP0001324_abnormal_eye_pigmentation0.90833109
78MP0005187_abnormal_penis_morphology0.90737504
79MP0003121_genomic_imprinting0.90203289
80MP0002063_abnormal_learning/memory/cond0.90041956
81MP0003698_abnormal_male_reproductive0.89033793
82MP0003635_abnormal_synaptic_transmissio0.88988177
83MP0002109_abnormal_limb_morphology0.88543063
84MP0005084_abnormal_gallbladder_morpholo0.88167102
85MP0009697_abnormal_copulation0.86831141
86MP0003186_abnormal_redox_activity0.86305873
87MP0000026_abnormal_inner_ear0.84856578
88MP0005391_vision/eye_phenotype0.84347967
89MP0002751_abnormal_autonomic_nervous0.83844738
90MP0002557_abnormal_social/conspecific_i0.82996481
91MP0001919_abnormal_reproductive_system0.82759714
92MP0002064_seizures0.82588015
93MP0008875_abnormal_xenobiotic_pharmacok0.81541802
94MP0002882_abnormal_neuron_morphology0.80639626
95MP0002653_abnormal_ependyma_morphology0.80282169
96MP0005253_abnormal_eye_physiology0.79687746
97MP0002092_abnormal_eye_morphology0.79089434
98MP0000428_abnormal_craniofacial_morphol0.76840603
99MP0003861_abnormal_nervous_system0.75553799
100MP0001529_abnormal_vocalization0.74612215

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)7.00951144
2Ridged nail (HP:0001807)4.90386440
3Reticulocytopenia (HP:0001896)4.41357605
4Abnormal ciliary motility (HP:0012262)4.00774027
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.92908168
6Absent/shortened dynein arms (HP:0200106)3.92908168
7Absent eyebrow (HP:0002223)3.64231231
8Supernumerary spleens (HP:0009799)3.39822615
9Premature skin wrinkling (HP:0100678)3.39237442
10Septo-optic dysplasia (HP:0100842)3.36317441
11Anhidrosis (HP:0000970)3.25569664
12Nephronophthisis (HP:0000090)3.19711002
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.18613290
14Medial flaring of the eyebrow (HP:0010747)3.14700993
15Abnormality of cells of the erythroid lineage (HP:0012130)2.95435332
16Molar tooth sign on MRI (HP:0002419)2.95068036
17Abnormality of midbrain morphology (HP:0002418)2.95068036
18Hemiparesis (HP:0001269)2.92198021
19Acute necrotizing encephalopathy (HP:0006965)2.87288960
20Abnormal respiratory motile cilium physiology (HP:0012261)2.85841332
21Stenosis of the external auditory canal (HP:0000402)2.80909348
22Chronic hepatic failure (HP:0100626)2.70451648
23Abnormal respiratory motile cilium morphology (HP:0005938)2.67472258
24Abnormal respiratory epithelium morphology (HP:0012253)2.67472258
25Gait imbalance (HP:0002141)2.66340418
26Vaginal atresia (HP:0000148)2.63798391
27Type II lissencephaly (HP:0007260)2.62791051
28Genital tract atresia (HP:0001827)2.56206219
29Congenital primary aphakia (HP:0007707)2.51295596
30Abnormality of the renal medulla (HP:0100957)2.49029108
31Progressive macrocephaly (HP:0004481)2.41105120
32Abnormal mitochondria in muscle tissue (HP:0008316)2.40000553
33Hypodontia (HP:0000668)2.37551764
34Macrocytic anemia (HP:0001972)2.35409579
35Abnormality of vitamin B metabolism (HP:0004340)2.34636962
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.33201116
37Mitochondrial inheritance (HP:0001427)2.30936342
38Hyperglycinemia (HP:0002154)2.29925811
39Acute encephalopathy (HP:0006846)2.28324260
40Abnormality of primary teeth (HP:0006481)2.27561903
41Cerebellar dysplasia (HP:0007033)2.25701239
42Cerebral edema (HP:0002181)2.25446493
43Fine hair (HP:0002213)2.22826996
44Nephrogenic diabetes insipidus (HP:0009806)2.22303866
45Asplenia (HP:0001746)2.20816909
46Absent hair (HP:0002298)2.17700681
47Increased CSF lactate (HP:0002490)2.16950446
48Respiratory difficulties (HP:0002880)2.16125540
49Disproportionate short-trunk short stature (HP:0003521)2.09313092
50Hyperventilation (HP:0002883)2.08325003
51Pancreatic fibrosis (HP:0100732)2.08264389
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.07467709
53Congenital stationary night blindness (HP:0007642)2.06993654
54Optic disc pallor (HP:0000543)2.06222838
55Myokymia (HP:0002411)2.05253383
56Amelogenesis imperfecta (HP:0000705)2.04650154
57Increased hepatocellular lipid droplets (HP:0006565)2.03023116
58Concave nail (HP:0001598)11.2977751
59Absent septum pellucidum (HP:0001331)1.98818707
60Depressed nasal ridge (HP:0000457)1.95820151
61Type 2 muscle fiber atrophy (HP:0003554)1.95533095
62Hypotrichosis (HP:0001006)1.93049962
63Polycystic ovaries (HP:0000147)1.88369218
64Abnormal hemoglobin (HP:0011902)1.84987301
65True hermaphroditism (HP:0010459)1.81536792
66Abnormality of the pons (HP:0007361)1.79627655
67Hyperinsulinemic hypoglycemia (HP:0000825)1.79608697
68Hypoplasia of the pons (HP:0012110)1.78874394
69Supernumerary bones of the axial skeleton (HP:0009144)1.75799444
70Postural instability (HP:0002172)1.75047046
71Renal Fanconi syndrome (HP:0001994)1.74753402
72Hypoplasia of the radius (HP:0002984)1.74472589
73Abnormal hair whorl (HP:0010721)1.74064742
74Glycosuria (HP:0003076)1.73594364
75Abnormality of urine glucose concentration (HP:0011016)1.73594364
76Pallor (HP:0000980)1.72555315
77Abnormality of serine family amino acid metabolism (HP:0010894)1.72457224
78Abnormality of glycine metabolism (HP:0010895)1.72457224
79Malignant hyperthermia (HP:0002047)1.72419402
80Sparse eyelashes (HP:0000653)1.71989146
81Global brain atrophy (HP:0002283)1.71884791
82Absent eyelashes (HP:0000561)1.70843539
833-Methylglutaconic aciduria (HP:0003535)1.70703371
84Poor coordination (HP:0002370)1.70620990
85Hypoplastic toenails (HP:0001800)1.67317023
86Methylmalonic acidemia (HP:0002912)1.67055997
87Progressive cerebellar ataxia (HP:0002073)1.65269585
88Lipid accumulation in hepatocytes (HP:0006561)1.64958715
89Short 4th metacarpal (HP:0010044)1.63618879
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63618879
91Pancreatic cysts (HP:0001737)1.63524188
92Oligodontia (HP:0000677)1.62288767
93Occipital encephalocele (HP:0002085)1.61090376
94Abnormality of the vitreous humor (HP:0004327)1.60560523
95Abnormal number of erythroid precursors (HP:0012131)1.60205720
96Abnormal rod and cone electroretinograms (HP:0008323)1.60016335
97Bilateral microphthalmos (HP:0007633)1.59672746
98Midline defect of the nose (HP:0004122)1.59670843
99Abnormality of vitamin metabolism (HP:0100508)1.59375220
100Morphological abnormality of the middle ear (HP:0008609)1.58683110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK28.58516051
2BCKDK3.94880283
3AKT33.54605385
4PNCK3.11322229
5STK162.57506787
6EPHA32.36774702
7MAP3K112.27688304
8PINK12.22845212
9MAP3K122.13149181
10MAPK151.94611205
11SIK21.85113013
12SGK21.73356195
13TNIK1.71633816
14TLK11.70643290
15DYRK31.70246051
16CDK191.68671934
17MAP4K11.67618047
18DYRK21.66377304
19SGK2231.55751168
20SGK4941.55751168
21TYRO31.34337944
22ADRBK21.30853594
23MAP3K41.30601642
24TXK1.29332091
25MAP2K41.27654229
26OXSR11.24538236
27MAPK131.21822193
28MAP2K71.16468571
29PAK31.11798347
30MAP4K21.10970285
31NTRK21.06533881
32CSNK1A1L1.02976362
33CDK30.94918902
34PHKG20.93948084
35PHKG10.93948084
36GRK10.93871146
37SGK30.91720169
38MARK30.89039246
39BRAF0.88753525
40NEK10.85952235
41WNK40.83747598
42CSNK1G30.81431674
43VRK10.81038040
44CDC70.79808889
45WNK30.78713358
46CSNK1G10.76653087
47CSNK1G20.75915818
48PRKCG0.72371060
49CAMK10.72136083
50MUSK0.70098939
51MARK10.69449448
52INSRR0.68878837
53TNK20.67484173
54MINK10.65197309
55DYRK1A0.65128764
56TSSK60.58138939
57PRKCE0.57949060
58MKNK10.53464461
59CAMKK20.49933139
60NUAK10.49922933
61CAMKK10.49808862
62CAMK2A0.48834549
63ZAK0.48817234
64CDK150.48712654
65MAP3K50.47304460
66TRIM280.47206111
67PASK0.47053264
68NTRK10.46865085
69EIF2AK10.46727182
70WNK10.46454735
71CAMK1G0.45317007
72CDK180.45290822
73PRKACA0.45266262
74DYRK1B0.44489685
75CASK0.43172389
76CDK140.43139699
77PRKCZ0.42976510
78CAMK40.41161871
79CDK50.40510051
80CSNK1E0.40351501
81CDK11A0.40155292
82CSNK2A20.39928417
83SGK10.39551564
84PLK40.39302864
85MKNK20.38014366
86OBSCN0.35432169
87RPS6KA10.35230527
88PRKG10.34689508
89PRKCB0.33479930
90CSNK2A10.31554085
91PRKCI0.31071330
92AURKB0.30608084
93CSNK1A10.28093662
94MAPK140.26904804
95PKN10.26588968
96PRKACB0.25798827
97GRK70.25723395
98PDK20.25624063
99PRKACG0.25454470
100PLK30.24353675

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.72381899
2Ribosome_Homo sapiens_hsa030104.46696064
3Parkinsons disease_Homo sapiens_hsa050124.13606862
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.67764343
5Cardiac muscle contraction_Homo sapiens_hsa042603.25039593
6Huntingtons disease_Homo sapiens_hsa050163.02189855
7Alzheimers disease_Homo sapiens_hsa050103.01408727
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99405708
9Protein export_Homo sapiens_hsa030602.84903925
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66801971
11Basal transcription factors_Homo sapiens_hsa030222.21699423
12Nicotine addiction_Homo sapiens_hsa050332.06249985
13Nitrogen metabolism_Homo sapiens_hsa009102.06102314
14Steroid biosynthesis_Homo sapiens_hsa001001.89636496
15Morphine addiction_Homo sapiens_hsa050321.78502026
16Propanoate metabolism_Homo sapiens_hsa006401.57498775
17GABAergic synapse_Homo sapiens_hsa047271.51350261
18Linoleic acid metabolism_Homo sapiens_hsa005911.39598316
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35506584
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33201672
21Collecting duct acid secretion_Homo sapiens_hsa049661.26445442
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24492082
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23055686
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22958874
25Basal cell carcinoma_Homo sapiens_hsa052171.20936978
26Chemical carcinogenesis_Homo sapiens_hsa052041.20607845
27Glutamatergic synapse_Homo sapiens_hsa047241.17535667
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17233959
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16914740
30Fanconi anemia pathway_Homo sapiens_hsa034601.16319584
31Butanoate metabolism_Homo sapiens_hsa006501.15957189
32Circadian entrainment_Homo sapiens_hsa047131.14655666
33Insulin secretion_Homo sapiens_hsa049111.10942364
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10265348
35Olfactory transduction_Homo sapiens_hsa047400.98938950
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.98336888
37Fat digestion and absorption_Homo sapiens_hsa049750.97336039
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95830263
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94567706
40Phototransduction_Homo sapiens_hsa047440.92221270
41Melanogenesis_Homo sapiens_hsa049160.91738000
42Folate biosynthesis_Homo sapiens_hsa007900.88943675
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87924585
44RNA degradation_Homo sapiens_hsa030180.87173362
45Caffeine metabolism_Homo sapiens_hsa002320.86935145
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84749175
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84613760
48Cocaine addiction_Homo sapiens_hsa050300.84480661
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83878494
50Dopaminergic synapse_Homo sapiens_hsa047280.82385543
51Proteasome_Homo sapiens_hsa030500.80287602
52Serotonergic synapse_Homo sapiens_hsa047260.79527615
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.76471189
54Oxytocin signaling pathway_Homo sapiens_hsa049210.74867037
55One carbon pool by folate_Homo sapiens_hsa006700.72351587
56Cholinergic synapse_Homo sapiens_hsa047250.71226032
57Glutathione metabolism_Homo sapiens_hsa004800.64576106
58Axon guidance_Homo sapiens_hsa043600.63528835
59Starch and sucrose metabolism_Homo sapiens_hsa005000.62259813
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.60139409
61Ether lipid metabolism_Homo sapiens_hsa005650.58295416
62Metabolic pathways_Homo sapiens_hsa011000.55405456
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55253130
64Arachidonic acid metabolism_Homo sapiens_hsa005900.53601151
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50601252
66Amphetamine addiction_Homo sapiens_hsa050310.48528509
67Hedgehog signaling pathway_Homo sapiens_hsa043400.47918559
68Taste transduction_Homo sapiens_hsa047420.47193677
69Gastric acid secretion_Homo sapiens_hsa049710.44134685
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43778986
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43217808
72Mineral absorption_Homo sapiens_hsa049780.42313686
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42210145
74Circadian rhythm_Homo sapiens_hsa047100.41321519
75Vitamin digestion and absorption_Homo sapiens_hsa049770.40544171
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40061785
77cAMP signaling pathway_Homo sapiens_hsa040240.39231482
78Hippo signaling pathway_Homo sapiens_hsa043900.38317803
79Homologous recombination_Homo sapiens_hsa034400.37743815
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37602384
81RNA transport_Homo sapiens_hsa030130.37521201
82Pancreatic secretion_Homo sapiens_hsa049720.37094403
83Tryptophan metabolism_Homo sapiens_hsa003800.35700826
84Synaptic vesicle cycle_Homo sapiens_hsa047210.34911675
85Long-term depression_Homo sapiens_hsa047300.34448835
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33823420
87Alcoholism_Homo sapiens_hsa050340.33069568
88Retinol metabolism_Homo sapiens_hsa008300.32485717
89Bile secretion_Homo sapiens_hsa049760.32442184
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31514321
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31074257
92Salivary secretion_Homo sapiens_hsa049700.27597116
93Peroxisome_Homo sapiens_hsa041460.25636679
94Dilated cardiomyopathy_Homo sapiens_hsa054140.25117805
95Thyroid hormone synthesis_Homo sapiens_hsa049180.24147626
96Wnt signaling pathway_Homo sapiens_hsa043100.23004760
97Regulation of autophagy_Homo sapiens_hsa041400.22855738
98Ovarian steroidogenesis_Homo sapiens_hsa049130.22358146
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21751772
100Glycerolipid metabolism_Homo sapiens_hsa005610.21316366

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »