ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	8.41099505
2	valine metabolic process (GO:0006573)	7.80142675
3	prenylation (GO:0097354)	6.60075458
4	protein prenylation (GO:0018342)	6.60075458
5	oxygen transport (GO:0015671)	6.38214070
6	viral transcription (GO:0019083)	5.28676218
7	gas transport (GO:0015669)	5.27302527
8	translational termination (GO:0006415)	5.18393975
9	mitochondrion transport along microtubule (GO:0047497)	5.01013208
10	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.01013208
11	cytokinetic process (GO:0032506)	4.94518835
12	ribosomal small subunit biogenesis (GO:0042274)	4.91890542
13	ribosomal large subunit biogenesis (GO:0042273)	4.80309517
14	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.73995799
15	protein targeting to ER (GO:0045047)	4.67959233
16	cotranslational protein targeting to membrane (GO:0006613)	4.66862591
17	negative regulation of glucose transport (GO:0010829)	4.59391625
18	sphingoid metabolic process (GO:0046519)	4.50794124
19	cardiovascular system development (GO:0072358)	4.45603540
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.45091208
21	regulation of triglyceride catabolic process (GO:0010896)	4.39689727
22	translational elongation (GO:0006414)	4.38805981
23	protein localization to endoplasmic reticulum (GO:0070972)	4.35077573
24	sphingosine metabolic process (GO:0006670)	4.34951315
25	negative regulation of glucose import (GO:0046325)	4.24674445
26	GTP biosynthetic process (GO:0006183)	4.20766679
27	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.16274489
28	protein maturation by protein folding (GO:0022417)	4.11108325
29	establishment of mitochondrion localization (GO:0051654)	4.07525602
30	N-terminal protein amino acid acetylation (GO:0006474)	3.98424012
31	diol metabolic process (GO:0034311)	3.97807141
32	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.86249741
33	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.81063453
34	macroautophagy (GO:0016236)	3.78751857
35	methionine biosynthetic process (GO:0009086)	3.78123361
36	seminiferous tubule development (GO:0072520)	3.72604416
37	UTP biosynthetic process (GO:0006228)	3.70430256
38	branched-chain amino acid catabolic process (GO:0009083)	3.63938852
39	viral life cycle (GO:0019058)	3.63145409
40	cellular protein complex disassembly (GO:0043624)	3.61470330
41	regulation of podosome assembly (GO:0071801)	3.60836814
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.58650479
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.58575070
44	ATP synthesis coupled proton transport (GO:0015986)	3.58575070
45	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.48209899
46	ribosomal small subunit assembly (GO:0000028)	3.45300234
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.44601940
48	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.41994823
49	amino acid salvage (GO:0043102)	3.40407476
50	L-methionine salvage (GO:0071267)	3.40407476
51	L-methionine biosynthetic process (GO:0071265)	3.40407476
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.34851731
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.34851731
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33848334
55	translational initiation (GO:0006413)	3.30056358
56	cardiolipin metabolic process (GO:0032048)	3.27927088
57	rRNA methylation (GO:0031167)	3.25642548
58	L-fucose catabolic process (GO:0042355)	3.19881843
59	fucose catabolic process (GO:0019317)	3.19881843
60	L-fucose metabolic process (GO:0042354)	3.19881843
61	UTP metabolic process (GO:0046051)	3.18171987
62	branched-chain amino acid metabolic process (GO:0009081)	3.18138905
63	sulfur amino acid catabolic process (GO:0000098)	3.17543155
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13799040
65	methionine metabolic process (GO:0006555)	3.09424980
66	translation (GO:0006412)	3.08466759
67	aspartate family amino acid biosynthetic process (GO:0009067)	3.08409587
68	regulation of cGMP metabolic process (GO:0030823)	2.98520434
69	regulation of B cell proliferation (GO:0030888)	2.95902683
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.95717035
71	detection of light stimulus involved in visual perception (GO:0050908)	2.95717035
72	protein targeting to membrane (GO:0006612)	2.95377229
73	positive regulation of immunoglobulin production (GO:0002639)	2.94846293
74	regulation of isotype switching to IgG isotypes (GO:0048302)	2.92099568
75	regulation of translation in response to stress (GO:0043555)	2.90260447
76	erythrocyte maturation (GO:0043249)	2.90176798
77	nucleoside diphosphate phosphorylation (GO:0006165)	2.89244560
78	nucleotide transmembrane transport (GO:1901679)	2.88501942
79	positive thymic T cell selection (GO:0045059)	2.85539964
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.81069899
81	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.76653055
82	protein complex disassembly (GO:0043241)	2.76284958
83	cellular extravasation (GO:0045123)	2.75492215
84	phosphatidylglycerol biosynthetic process (GO:0006655)	2.74914392
85	positive T cell selection (GO:0043368)	2.74204760
86	sulfur amino acid biosynthetic process (GO:0000097)	2.73694844
87	positive regulation of granulocyte differentiation (GO:0030854)	2.72082893
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.71672138
89	hepatocyte apoptotic process (GO:0097284)	2.70735255
90	CTP biosynthetic process (GO:0006241)	2.70732712
91	CTP metabolic process (GO:0046036)	2.70732712
92	DNA deamination (GO:0045006)	2.69131226
93	rRNA modification (GO:0000154)	2.68476708
94	cellular response to ethanol (GO:0071361)	2.65340419
95	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.65239241
96	positive regulation of B cell proliferation (GO:0030890)	2.64771758
97	macromolecular complex disassembly (GO:0032984)	2.64293319
98	regulation of B cell receptor signaling pathway (GO:0050855)	2.62577787
99	regulation of germinal center formation (GO:0002634)	2.61530712
100	cellular modified amino acid catabolic process (GO:0042219)	2.59489404

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.81656466
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	5.26137451
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.77396840
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46432298
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.04671290
6	VDR_22108803_ChIP-Seq_LS180_Human	2.83747184
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.81586525
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.81442889
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.80049580
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.72507255
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.66612641
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.61018879
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.51024837
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33249315
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.31001274
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.27334042
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21044007
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.11933383
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08087195
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01818191
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.84304172
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.79366799
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78578067
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64095482
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.62279948
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59304358
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57889578
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56301462
29	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.48394125
30	RUNX_20019798_ChIP-Seq_JUKART_Human	1.48066580
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42127150
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40920221
33	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.38844021
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35854267
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35854267
36	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.34091572
37	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.33824256
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33568524
39	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.32321715
40	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.22680352
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22114218
42	GATA3_26560356_Chip-Seq_TH2_Human	1.21995222
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.20789395
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20789395
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20452606
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20241935
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20084740
48	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.19936547
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.19706260
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19321942
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17506280
52	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.17207586
53	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.16334201
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15087836
55	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.12423861
56	SMRT_27268052_Chip-Seq_Bcells_Human	1.08878955
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08681420
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06125134
59	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03825778
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02911570
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02628763
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02326930
63	SPI1_23547873_ChIP-Seq_NB4_Human	1.01686455
64	FUS_26573619_Chip-Seq_HEK293_Human	1.00974493
65	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98740184
66	MYB_26560356_Chip-Seq_TH2_Human	0.97308539
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96341199
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96341199
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95078813
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94036479
71	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93844450
72	CEBPB_22108803_ChIP-Seq_LS180_Human	0.93673045
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93630563
74	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93151234
75	EWS_26573619_Chip-Seq_HEK293_Human	0.92423184
76	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.92368335
77	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.91933303
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91631487
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.90822060
80	PHF8_20622853_ChIP-Seq_HELA_Human	0.90195738
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89497176
82	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.88475851
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.88207953
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.88002079
85	P300_19829295_ChIP-Seq_ESCs_Human	0.87726001
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87396540
87	GATA3_26560356_Chip-Seq_TH1_Human	0.85726993
88	SPI1_20517297_ChIP-Seq_HL60_Human	0.85577277
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.84777935
90	ERA_21632823_ChIP-Seq_H3396_Human	0.84706458
91	STAT1_20625510_ChIP-Seq_HELA_Human	0.84009217
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83900516
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.83561732
94	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.83065287
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.82762035
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.82043588
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.81760981
98	BCL6_27268052_Chip-Seq_Bcells_Human	0.81690837
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.79705900
100	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.79472197

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.00569476
2	MP0003646_muscle_fatigue	5.54555036
3	MP0000569_abnormal_digit_pigmentation	4.25079605
4	MP0005397_hematopoietic_system_phenotyp	4.06531121
5	MP0001545_abnormal_hematopoietic_system	4.06531121
6	MP0004145_abnormal_muscle_electrophysio	3.53070861
7	MP0003656_abnormal_erythrocyte_physiolo	3.17817653
8	MP0000015_abnormal_ear_pigmentation	3.16220964
9	MP0002837_dystrophic_cardiac_calcinosis	2.73764587
10	MP0002095_abnormal_skin_pigmentation	2.31940059
11	MP0004147_increased_porphyrin_level	2.31246116
12	MP0008875_abnormal_xenobiotic_pharmacok	2.18816533
13	MP0005671_abnormal_response_to	2.18498378
14	MP0004858_abnormal_nervous_system	2.14159157
15	MP0003303_peritoneal_inflammation	2.12801864
16	MP0005085_abnormal_gallbladder_physiolo	2.11167680
17	MP0001873_stomach_inflammation	1.91304276
18	MP0002138_abnormal_hepatobiliary_system	1.90378547
19	MP0003195_calcinosis	1.88172232
20	MP0004130_abnormal_muscle_cell	1.77759521
21	MP0002132_abnormal_respiratory_system	1.77160634
22	MP0008058_abnormal_DNA_repair	1.74064782
23	MP0001800_abnormal_humoral_immune	1.68432807
24	MP0001529_abnormal_vocalization	1.60826818
25	MP0003186_abnormal_redox_activity	1.56089613
26	MP0003878_abnormal_ear_physiology	1.52656060
27	MP0005377_hearing/vestibular/ear_phenot	1.52656060
28	MP0002277_abnormal_respiratory_mucosa	1.51241420
29	MP0003045_fibrosis	1.50469897
30	MP0005174_abnormal_tail_pigmentation	1.49948254
31	MP0003136_yellow_coat_color	1.49289916
32	MP0004036_abnormal_muscle_relaxation	1.44977810
33	MP0004381_abnormal_hair_follicle	1.39448881
34	MP0008872_abnormal_physiological_respon	1.36322870
35	MP0002102_abnormal_ear_morphology	1.35822287
36	MP0005645_abnormal_hypothalamus_physiol	1.32347964
37	MP0005171_absent_coat_pigmentation	1.29906890
38	MP0005360_urolithiasis	1.22256918
39	MP0001764_abnormal_homeostasis	1.21132410
40	MP0002254_reproductive_system_inflammat	1.20562480
41	MP0004084_abnormal_cardiac_muscle	1.17899538
42	MP0003252_abnormal_bile_duct	1.14947048
43	MP0005551_abnormal_eye_electrophysiolog	1.14863568
44	MP0001663_abnormal_digestive_system	1.14532614
45	MP0002452_abnormal_antigen_presenting	1.12063813
46	MP0005075_abnormal_melanosome_morpholog	1.09153404
47	MP0006054_spinal_hemorrhage	1.08828719
48	MP0001835_abnormal_antigen_presentation	1.06614284
49	MP0002723_abnormal_immune_serum	1.06065973
50	MP0009764_decreased_sensitivity_to	1.04724671
51	MP0005389_reproductive_system_phenotype	1.02010111
52	MP0001919_abnormal_reproductive_system	0.93564993
53	MP0000678_abnormal_parathyroid_gland	0.90118774
54	MP0002420_abnormal_adaptive_immunity	0.89486907
55	MP0003806_abnormal_nucleotide_metabolis	0.88866651
56	MP0006036_abnormal_mitochondrial_physio	0.88626365
57	MP0001819_abnormal_immune_cell	0.86433098
58	MP0000470_abnormal_stomach_morphology	0.85625834
59	MP0002398_abnormal_bone_marrow	0.85610355
60	MP0001348_abnormal_lacrimal_gland	0.84204356
61	MP0004883_abnormal_blood_vessel	0.82866255
62	MP0008995_early_reproductive_senescence	0.82285133
63	MP0002148_abnormal_hypersensitivity_rea	0.81635103
64	MP0008877_abnormal_DNA_methylation	0.81243040
65	MP0001845_abnormal_inflammatory_respons	0.80260590
66	MP0005000_abnormal_immune_tolerance	0.80221901
67	MP0005332_abnormal_amino_acid	0.79965703
68	MP0000716_abnormal_immune_system	0.79655527
69	MP0000689_abnormal_spleen_morphology	0.79155213
70	MP0002168_other_aberrant_phenotype	0.78554961
71	MP0002160_abnormal_reproductive_system	0.78259494
72	MP0004142_abnormal_muscle_tone	0.77730481
73	MP0000685_abnormal_immune_system	0.76446866
74	MP0004808_abnormal_hematopoietic_stem	0.76401149
75	MP0003718_maternal_effect	0.76100609
76	MP0002429_abnormal_blood_cell	0.76087997
77	MP0005636_abnormal_mineral_homeostasis	0.74281615
78	MP0009765_abnormal_xenobiotic_induced	0.72695088
79	MP0005381_digestive/alimentary_phenotyp	0.70247527
80	MP0005464_abnormal_platelet_physiology	0.69939837
81	MP0002419_abnormal_innate_immunity	0.67834661
82	MP0001790_abnormal_immune_system	0.67372556
83	MP0005387_immune_system_phenotype	0.67372556
84	MP0004742_abnormal_vestibular_system	0.66910714
85	MP0002638_abnormal_pupillary_reflex	0.65541439
86	MP0002722_abnormal_immune_system	0.63118049
87	MP0005395_other_phenotype	0.62946568
88	MP0000750_abnormal_muscle_regeneration	0.62547823
89	MP0002229_neurodegeneration	0.62248781
90	MP0008775_abnormal_heart_ventricle	0.61679718
91	MP0005365_abnormal_bile_salt	0.61209715
92	MP0009278_abnormal_bone_marrow	0.60647859
93	MP0003075_altered_response_to	0.58940696
94	MP0005646_abnormal_pituitary_gland	0.57759446
95	MP0002234_abnormal_pharynx_morphology	0.57245202
96	MP0002653_abnormal_ependyma_morphology	0.56509928
97	MP0001440_abnormal_grooming_behavior	0.56492730
98	MP0010329_abnormal_lipoprotein_level	0.55924738
99	MP0002127_abnormal_cardiovascular_syste	0.54235871
100	MP0001661_extended_life_span	0.53992151

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	8.12094119
2	Acanthocytosis (HP:0001927)	7.84102584
3	Pendular nystagmus (HP:0012043)	5.60408417
4	Abnormal rod and cone electroretinograms (HP:0008323)	5.57330024
5	Acute hepatic failure (HP:0006554)	5.11496898
6	Abnormal hemoglobin (HP:0011902)	5.01056456
7	Decreased central vision (HP:0007663)	4.47193386
8	Increased corneal curvature (HP:0100692)	4.04103114
9	Keratoconus (HP:0000563)	4.04103114
10	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.96099338
11	Self-mutilation (HP:0000742)	3.77905455
12	Pallor (HP:0000980)	3.72429397
13	Poikilocytosis (HP:0004447)	3.72196874
14	Disinhibition (HP:0000734)	3.70982516
15	Gastrointestinal infarctions (HP:0005244)	3.66112921
16	Attenuation of retinal blood vessels (HP:0007843)	3.64909765
17	Personality changes (HP:0000751)	3.19992373
18	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.03128702
19	Acute necrotizing encephalopathy (HP:0006965)	2.94718597
20	Carpal bone hypoplasia (HP:0001498)	2.91325430
21	Nonimmune hydrops fetalis (HP:0001790)	2.90494948
22	Renal Fanconi syndrome (HP:0001994)	2.89855042
23	Exertional dyspnea (HP:0002875)	2.86659508
24	Progressive macrocephaly (HP:0004481)	2.77987580
25	Thrombocytosis (HP:0001894)	2.65874778
26	Rectal prolapse (HP:0002035)	2.61720020
27	Acute encephalopathy (HP:0006846)	2.55305443
28	Irregular epiphyses (HP:0010582)	2.54579833
29	Glucose intolerance (HP:0000833)	2.53785716
30	Dyskinesia (HP:0100660)	2.53122303
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46013586
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38200387
33	Albinism (HP:0001022)	2.38087847
34	Increased hepatocellular lipid droplets (HP:0006565)	2.36781426
35	Abnormality of homocysteine metabolism (HP:0010919)	2.34192562
36	Homocystinuria (HP:0002156)	2.34192562
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.34040136
38	Lipid accumulation in hepatocytes (HP:0006561)	2.27405666
39	Toxemia of pregnancy (HP:0100603)	2.27380872
40	Vasculitis (HP:0002633)	2.24051772
41	Microcytic anemia (HP:0001935)	2.23777627
42	Abnormality of the costochondral junction (HP:0000919)	2.22042684
43	Macrocytic anemia (HP:0001972)	2.17754970
44	Inappropriate behavior (HP:0000719)	2.15808373
45	Abnormal number of erythroid precursors (HP:0012131)	2.13634600
46	Recurrent sinusitis (HP:0011108)	2.11652374
47	Beaking of vertebral bodies (HP:0004568)	2.09980464
48	Spastic paraparesis (HP:0002313)	2.06740920
49	Mitochondrial inheritance (HP:0001427)	2.04779039
50	Type I transferrin isoform profile (HP:0003642)	2.03915591
51	Posterior subcapsular cataract (HP:0007787)	2.02934856
52	Optic disc pallor (HP:0000543)	2.02909363
53	Hypoalbuminemia (HP:0003073)	2.02768664
54	Abnormal albumin level (HP:0012116)	2.02768664
55	Psychosis (HP:0000709)	2.01345024
56	Peritonitis (HP:0002586)	2.00949060
57	Limb hypertonia (HP:0002509)	2.00833462
58	Hypoplastic iliac wings (HP:0002866)	2.00585027
59	Cerebral edema (HP:0002181)	1.99932946
60	Hypothermia (HP:0002045)	1.99235774
61	Anencephaly (HP:0002323)	1.96934720
62	Increased intramyocellular lipid droplets (HP:0012240)	1.96799249
63	Hypochromic anemia (HP:0001931)	1.96493924
64	Barrel-shaped chest (HP:0001552)	1.94117072
65	Elevated erythrocyte sedimentation rate (HP:0003565)	1.92552937
66	Cerebral hypomyelination (HP:0006808)	1.91792888
67	Choreoathetosis (HP:0001266)	1.91536177
68	Macular degeneration (HP:0000608)	1.91524444
69	Hematochezia (HP:0002573)	1.91442053
70	Tetany (HP:0001281)	1.89215271
71	Delusions (HP:0000746)	1.88709900
72	Abnormality of renal resorption (HP:0011038)	1.88406148
73	Constricted visual fields (HP:0001133)	1.86865683
74	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.85868756
75	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.85868756
76	Oligomenorrhea (HP:0000876)	1.85261361
77	Increased CSF lactate (HP:0002490)	1.83313013
78	Hyperphosphaturia (HP:0003109)	1.82705085
79	Amelogenesis imperfecta (HP:0000705)	1.81320436
80	Abnormality of potassium homeostasis (HP:0011042)	1.80102489
81	Atonic seizures (HP:0010819)	1.79916559
82	Subcapsular cataract (HP:0000523)	1.78409670
83	Hyperthyroidism (HP:0000836)	1.78215074
84	Pancreatic cysts (HP:0001737)	1.76678682
85	Hypokalemia (HP:0002900)	1.73743867
86	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.72503663
87	Upper motor neuron abnormality (HP:0002127)	1.72187561
88	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.71725368
89	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.71261518
90	Increased muscle lipid content (HP:0009058)	1.70698483
91	Abnormality of fatty-acid metabolism (HP:0004359)	1.68353094
92	Congenital ichthyosiform erythroderma (HP:0007431)	1.67923161
93	IgG deficiency (HP:0004315)	1.66700446
94	True hermaphroditism (HP:0010459)	1.66024424
95	Generalized aminoaciduria (HP:0002909)	1.64403879
96	Thickened calvaria (HP:0002684)	1.64356730
97	Recurrent pneumonia (HP:0006532)	1.63664214
98	Spontaneous abortion (HP:0005268)	1.63604441
99	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.62667998
100	Hypokinesia (HP:0002375)	1.61679879

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.91392060
2	CAMKK2	4.31117456
3	RIPK4	3.64859303
4	BRSK2	3.39386483
5	MAP4K1	2.97807570
6	BMPR2	2.94575172
7	STK38L	2.83423522
8	PKN2	2.77686111
9	LATS1	2.56039103
10	FRK	2.46545244
11	AKT3	2.42715895
12	CAMKK1	2.24401521
13	FLT3	2.23203649
14	PIK3CG	2.23108872
15	STK24	1.80030228
16	GRK6	1.64199816
17	IRAK4	1.61354126
18	ACVR1B	1.50339702
19	BRSK1	1.48430376
20	TAOK3	1.41710079
21	WNK3	1.36482635
22	TEC	1.33633857
23	TYK2	1.31638297
24	BMPR1B	1.26962618
25	TXK	1.26578853
26	IRAK2	1.21163544
27	TLK1	1.14223109
28	WNK4	1.12856795
29	BLK	1.07536370
30	SYK	1.07202105
31	PDK2	1.06085461
32	MELK	1.05661100
33	LRRK2	1.03763774
34	MAP3K12	1.02991904
35	ITK	1.01895753
36	BTK	1.00303933
37	ZAK	0.99801214
38	ADRBK2	0.94982064
39	STK11	0.92218741
40	ABL2	0.91374357
41	STK4	0.91170199
42	IRAK1	0.89648586
43	PBK	0.89204159
44	BCKDK	0.87431464
45	JAK3	0.84889773
46	IKBKB	0.84405697
47	ADRBK1	0.84391992
48	OBSCN	0.83407216
49	MAP3K11	0.82255684
50	RPS6KB2	0.78342826
51	MET	0.76202263
52	IKBKE	0.76102693
53	NLK	0.75459012
54	NME1	0.74267083
55	STK3	0.73996016
56	LATS2	0.73962501
57	MKNK2	0.72994065
58	PAK3	0.68928980
59	PRKCQ	0.68251100
60	RPS6KA6	0.67889988
61	GRK1	0.67789585
62	OXSR1	0.66834786
63	STK39	0.66328498
64	EIF2AK1	0.61235691
65	HCK	0.58601078
66	RPS6KB1	0.57753961
67	PIM1	0.55931679
68	RPS6KC1	0.55204109
69	RPS6KL1	0.55204109
70	PASK	0.54574006
71	MAP3K2	0.53248602
72	KSR2	0.51984870
73	JAK2	0.50288453
74	CSK	0.47032435
75	EIF2AK3	0.46937934
76	PRKACA	0.46789918
77	PKN1	0.46066213
78	GRK7	0.45666658
79	MAP3K4	0.43795953
80	TGFBR2	0.42750060
81	PRKAA2	0.42502565
82	PRKACG	0.36231721
83	MATK	0.35968858
84	LYN	0.35530300
85	FGFR1	0.35429241
86	IGF1R	0.35173698
87	CSNK2A2	0.34735038
88	TNIK	0.34386808
89	ILK	0.34375237
90	MKNK1	0.33207242
91	PDK1	0.32051242
92	PDPK1	0.31447940
93	TRPM7	0.31439981
94	TNK2	0.31344772
95	WNK1	0.30087398
96	LCK	0.27367549
97	PRKCH	0.26431148
98	MAPK3	0.26077298
99	NTRK3	0.25400525
100	CAMK1	0.24757818

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.23158899
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.98789439
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.94444431
4	Asthma_Homo sapiens_hsa05310	2.92100516
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.86382898
6	Protein export_Homo sapiens_hsa03060	2.48509254
7	Parkinsons disease_Homo sapiens_hsa05012	2.38139691
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13888590
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.10400647
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.08980031
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.08639068
12	Allograft rejection_Homo sapiens_hsa05330	2.06932263
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.93343891
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88293095
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.85393256
16	RNA degradation_Homo sapiens_hsa03018	1.78665533
17	Sulfur metabolism_Homo sapiens_hsa00920	1.76718560
18	One carbon pool by folate_Homo sapiens_hsa00670	1.69652941
19	Alzheimers disease_Homo sapiens_hsa05010	1.68576145
20	Phototransduction_Homo sapiens_hsa04744	1.68273043
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.64267051
22	Huntingtons disease_Homo sapiens_hsa05016	1.63066486
23	Olfactory transduction_Homo sapiens_hsa04740	1.61566261
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52868516
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.38271908
26	Sulfur relay system_Homo sapiens_hsa04122	1.34767646
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.29708526
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29227624
29	RNA polymerase_Homo sapiens_hsa03020	1.29151821
30	Basal transcription factors_Homo sapiens_hsa03022	1.26309519
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25760117
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18650741
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.17241555
34	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.15327441
35	ABC transporters_Homo sapiens_hsa02010	1.11784054
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10341007
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08442033
38	Leishmaniasis_Homo sapiens_hsa05140	1.07979297
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07954933
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06680567
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.01771488
42	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.01407306
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01011548
44	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.95306727
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.94827340
46	Proteasome_Homo sapiens_hsa03050	0.90596489
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.89316771
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86687045
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84470332
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.82611638
51	Taste transduction_Homo sapiens_hsa04742	0.81567610
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.79806793
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74535723
54	Regulation of autophagy_Homo sapiens_hsa04140	0.73948371
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72900713
56	Nicotine addiction_Homo sapiens_hsa05033	0.72837892
57	Morphine addiction_Homo sapiens_hsa05032	0.72241982
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71170549
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.69042827
60	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.67779309
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.65711303
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63410584
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62002429
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61634155
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58811743
66	Malaria_Homo sapiens_hsa05144	0.56959163
67	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.55436267
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53970337
69	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53137176
70	Retinol metabolism_Homo sapiens_hsa00830	0.53009120
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.52928520
72	mTOR signaling pathway_Homo sapiens_hsa04150	0.51530961
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50658169
74	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.47118955
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45564823
76	Chemokine signaling pathway_Homo sapiens_hsa04062	0.45137515
77	Mineral absorption_Homo sapiens_hsa04978	0.43590133
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42638057
79	Metabolic pathways_Homo sapiens_hsa01100	0.42195888
80	Legionellosis_Homo sapiens_hsa05134	0.41950893
81	Caffeine metabolism_Homo sapiens_hsa00232	0.41591080
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38582359
83	Serotonergic synapse_Homo sapiens_hsa04726	0.36861015
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36300925
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.36165830
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36130804
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35712281
88	Tuberculosis_Homo sapiens_hsa05152	0.34719107
89	Peroxisome_Homo sapiens_hsa04146	0.33058179
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32679951
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.31035498
92	African trypanosomiasis_Homo sapiens_hsa05143	0.30830533
93	Pancreatic secretion_Homo sapiens_hsa04972	0.30180950
94	Measles_Homo sapiens_hsa05162	0.28380405
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27446787
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25641129
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.24403974
98	Thyroid cancer_Homo sapiens_hsa05216	0.23369172
99	Acute myeloid leukemia_Homo sapiens_hsa05221	0.23324061
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21894225

TPT1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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