TPT1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)9.82382402
2mannose metabolic process (GO:0006013)9.55568419
3chaperone-mediated protein transport (GO:0072321)9.30973241
4ncRNA 3-end processing (GO:0043628)8.15279310
5nucleoside transmembrane transport (GO:1901642)7.58454808
6homocysteine metabolic process (GO:0050667)7.28503122
7viral transcription (GO:0019083)6.41781700
8translational termination (GO:0006415)6.08769218
9nucleoside transport (GO:0015858)5.81442042
10translational elongation (GO:0006414)5.67972118
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.63100026
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.02237319
13ATP synthesis coupled proton transport (GO:0015986)5.02237319
14ribonucleoprotein complex biogenesis (GO:0022613)4.98369010
15interferon-gamma production (GO:0032609)4.96596614
16ribosomal small subunit assembly (GO:0000028)4.93734039
17NADH metabolic process (GO:0006734)4.73838587
18cellular protein complex disassembly (GO:0043624)4.72776152
19monoubiquitinated protein deubiquitination (GO:0035520)4.71692081
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69422277
21ribosomal large subunit biogenesis (GO:0042273)4.68330472
22viral life cycle (GO:0019058)4.63823270
23cotranslational protein targeting to membrane (GO:0006613)4.57190039
24negative regulation of cAMP-mediated signaling (GO:0043951)4.55456108
25protein targeting to ER (GO:0045047)4.52414805
26response to muscle activity (GO:0014850)4.49687157
27cellular component biogenesis (GO:0044085)4.46755384
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.42152166
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40807050
30DNA deamination (GO:0045006)4.38211149
31protein prenylation (GO:0018342)4.34553716
32prenylation (GO:0097354)4.34553716
33peroxisome fission (GO:0016559)4.33628900
34cAMP catabolic process (GO:0006198)4.32364911
35protein localization to endoplasmic reticulum (GO:0070972)4.22093372
36GMP metabolic process (GO:0046037)4.21348831
37modified amino acid transport (GO:0072337)4.17391535
38endocardial cushion morphogenesis (GO:0003203)4.14859332
39reproduction (GO:0000003)4.14650586
40hepatocyte differentiation (GO:0070365)4.10978258
41cofactor transport (GO:0051181)4.09360073
42protein localization to peroxisome (GO:0072662)3.93072216
43protein targeting to peroxisome (GO:0006625)3.93072216
44establishment of protein localization to peroxisome (GO:0072663)3.93072216
45protein complex disassembly (GO:0043241)3.90484721
46establishment of apical/basal cell polarity (GO:0035089)3.86340985
47polarized epithelial cell differentiation (GO:0030859)3.81125924
48nucleotide-sugar biosynthetic process (GO:0009226)3.70138463
49regulation of energy homeostasis (GO:2000505)3.69025283
50translational initiation (GO:0006413)3.68625605
51cyclic nucleotide catabolic process (GO:0009214)3.63381651
52peroxisomal transport (GO:0043574)3.62935602
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60732759
54cellular response to epinephrine stimulus (GO:0071872)3.59631861
55phosphatidylglycerol biosynthetic process (GO:0006655)3.57589079
56positive regulation of odontogenesis (GO:0042482)3.53561389
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52430432
58citrulline biosynthetic process (GO:0019240)3.51727078
59macromolecular complex disassembly (GO:0032984)3.51144924
60response to pheromone (GO:0019236)3.46177791
61mitochondrion distribution (GO:0048311)3.42848912
62nuclear-transcribed mRNA catabolic process (GO:0000956)3.37849147
63coenzyme A biosynthetic process (GO:0015937)3.37299359
64cardiolipin metabolic process (GO:0032048)3.37023331
65regulation of sister chromatid cohesion (GO:0007063)3.36362999
66regulation of relaxation of muscle (GO:1901077)3.35139565
67establishment or maintenance of monopolar cell polarity (GO:0061339)3.32906173
68establishment of monopolar cell polarity (GO:0061162)3.32906173
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32136941
70regulation of mitochondrial membrane potential (GO:0051881)3.30570897
71protein targeting to membrane (GO:0006612)3.28691023
72endoderm formation (GO:0001706)3.24182691
73response to dexamethasone (GO:0071548)3.19995607
74regulation of cell communication by electrical coupling (GO:0010649)3.19295714
75intracellular protein transmembrane import (GO:0044743)3.18572910
76positive regulation of protein kinase C signaling (GO:0090037)3.14313846
77mRNA catabolic process (GO:0006402)3.13292957
78mesenchyme morphogenesis (GO:0072132)3.12452471
79translation (GO:0006412)3.07060817
80outer ear morphogenesis (GO:0042473)3.05050930
81response to epinephrine (GO:0071871)3.04329557
82sulfur compound transport (GO:0072348)3.02965639
83pantothenate metabolic process (GO:0015939)2.98323208
84activated T cell proliferation (GO:0050798)2.93709229
85DNA synthesis involved in DNA repair (GO:0000731)2.86886070
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84256904
87ATP biosynthetic process (GO:0006754)2.82150391
88oxygen transport (GO:0015671)2.82099899
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.79011491
90ribosome biogenesis (GO:0042254)2.78382160
91rRNA processing (GO:0006364)2.78007805
92cellular response to estradiol stimulus (GO:0071392)2.75104869
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73709475
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73709475
95RNA catabolic process (GO:0006401)2.71162809
96midgut development (GO:0007494)2.71085665
97regulation of centriole replication (GO:0046599)2.68693157
98meiotic chromosome segregation (GO:0045132)2.68513599
99positive regulation of transcription regulatory region DNA binding (GO:2000679)2.67862539
100ribosomal small subunit biogenesis (GO:0042274)11.6664835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat9.54857155
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse8.58181402
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.12214149
4GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.55122004
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.50875719
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.34532472
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31827520
8BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.31722451
9GATA6_21074721_ChIP-Seq_CACO-2_Human2.14495372
10CDX2_21074721_ChIP-Seq_CACO-2_Mouse2.06413181
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.04513088
12RBPJ_21746931_ChIP-Seq_IB4_Human2.04096003
13EGR1_19032775_ChIP-ChIP_M12_Human2.03942162
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.00816947
15PHF8_20622853_ChIP-Seq_HELA_Human1.94037003
16HNFA_21074721_ChIP-Seq_CACO-2_Human1.92013969
17ETV1_20927104_ChIP-Seq_GIST48_Human1.90307893
18ZNF263_19887448_ChIP-Seq_K562_Human1.89389288
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87207139
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85655244
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.82694425
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78430466
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78181760
24XRN2_22483619_ChIP-Seq_HELA_Human1.72803235
25NFYB_21822215_ChIP-Seq_K562_Human1.71435273
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70683282
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68914868
28KDM5A_27292631_Chip-Seq_BREAST_Human1.68574867
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66866066
30FUS_26573619_Chip-Seq_HEK293_Human1.66152249
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65591019
32NFYA_21822215_ChIP-Seq_K562_Human1.62459556
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.61066096
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.60637591
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59317971
36CBX2_22325352_ChIP-Seq_293T-Rex_Human1.58933118
37PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.56020020
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53366290
39AR_21572438_ChIP-Seq_LNCaP_Human1.51439052
40TAF15_26573619_Chip-Seq_HEK293_Human1.49129028
41SA1_27219007_Chip-Seq_Bcells_Human1.46939522
42EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.42973379
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.41944841
44EWS_26573619_Chip-Seq_HEK293_Human1.40117421
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36657454
46RNF2_27304074_Chip-Seq_NSC_Mouse1.34817022
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34063038
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31262067
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28988096
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.27728184
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27591123
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26943578
53E2F1_20622854_ChIP-Seq_HELA_Human1.22565919
54TBL1_22424771_ChIP-Seq_293T_Human1.21856372
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20392806
56NANOG_20526341_ChIP-Seq_ESCs_Human1.19281224
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19153719
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17440256
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17440256
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17440256
61RUNX_20019798_ChIP-Seq_JUKART_Human1.16778757
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.11282105
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08323931
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07258801
65ELK1_19687146_ChIP-ChIP_HELA_Human1.05480691
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02507915
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01340148
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01036403
69CTCF_27219007_Chip-Seq_Bcells_Human1.00866162
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00515607
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00289907
72VDR_23849224_ChIP-Seq_CD4+_Human0.99428930
73ERA_21632823_ChIP-Seq_H3396_Human0.95672221
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95377004
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95074605
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91140811
77GATA3_26560356_Chip-Seq_TH1_Human0.89573600
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88392279
79BCL6_27268052_Chip-Seq_Bcells_Human0.88012280
80MAF_26560356_Chip-Seq_TH2_Human0.87465328
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87447024
82P53_21459846_ChIP-Seq_SAOS-2_Human0.86973980
83CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86360462
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85740607
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.85346477
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84784879
87PHF8_20622854_ChIP-Seq_HELA_Human0.83527515
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82696893
89MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82539209
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.82470634
91SMC4_20622854_ChIP-Seq_HELA_Human0.80470606
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79569587
93MYC_19829295_ChIP-Seq_ESCs_Human0.78548772
94CTCF_20526341_ChIP-Seq_ESCs_Human0.78254548
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.77362092
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76965636
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76899978
98EGR1_19374776_ChIP-ChIP_THP-1_Human0.76519975
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.76371502
100MAF_26560356_Chip-Seq_TH1_Human0.75656227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract7.28935591
2MP0004510_myositis5.02725413
3MP0002638_abnormal_pupillary_reflex4.96655265
4MP0001873_stomach_inflammation4.55148884
5MP0001727_abnormal_embryo_implantation4.40221736
6MP0006082_CNS_inflammation4.29754798
7MP0003879_abnormal_hair_cell3.77208502
8MP0003646_muscle_fatigue2.94151371
9MP0005085_abnormal_gallbladder_physiolo2.85121466
10MP0006072_abnormal_retinal_apoptosis2.63689572
11MP0003693_abnormal_embryo_hatching2.41074763
12MP0005220_abnormal_exocrine_pancreas2.28218061
13MP0009379_abnormal_foot_pigmentation2.27246153
14MP0002933_joint_inflammation2.20490820
15MP0005671_abnormal_response_to2.16625721
16MP0009333_abnormal_splenocyte_physiolog2.11025023
17MP0000015_abnormal_ear_pigmentation1.96437076
18MP0005174_abnormal_tail_pigmentation1.83690537
19MP0002163_abnormal_gland_morphology1.76388755
20MP0008875_abnormal_xenobiotic_pharmacok1.69724764
21MP0006292_abnormal_olfactory_placode1.66133303
22MP0004133_heterotaxia1.53722304
23MP0004043_abnormal_pH_regulation1.52553478
24MP0009250_abnormal_appendicular_skeleto1.49311634
25MP0004858_abnormal_nervous_system1.47815512
26MP0002160_abnormal_reproductive_system1.43855576
27MP0003878_abnormal_ear_physiology1.35214427
28MP0005377_hearing/vestibular/ear_phenot1.35214427
29MP0002837_dystrophic_cardiac_calcinosis1.16377939
30MP0003121_genomic_imprinting1.15739599
31MP0004147_increased_porphyrin_level1.12227021
32MP0003195_calcinosis1.07282164
33MP0002971_abnormal_brown_adipose1.05372571
34MP0001663_abnormal_digestive_system1.04019249
35MP0001905_abnormal_dopamine_level1.01909752
36MP0003763_abnormal_thymus_physiology1.01467204
37MP0001800_abnormal_humoral_immune1.01087180
38MP0009765_abnormal_xenobiotic_induced1.00620603
39MP0001790_abnormal_immune_system1.00367010
40MP0005387_immune_system_phenotype1.00367010
41MP0000678_abnormal_parathyroid_gland1.00038170
42MP0001851_eye_inflammation0.96989888
43MP0005389_reproductive_system_phenotype0.94616483
44MP0001835_abnormal_antigen_presentation0.93567192
45MP0005076_abnormal_cell_differentiation0.92995994
46MP0005253_abnormal_eye_physiology0.92764663
47MP0009785_altered_susceptibility_to0.92415125
48MP0009764_decreased_sensitivity_to0.88666475
49MP0006138_congestive_heart_failure0.86173915
50MP0002095_abnormal_skin_pigmentation0.85757408
51MP0000579_abnormal_nail_morphology0.84275257
52MP0005195_abnormal_posterior_eye0.84224474
53MP0005319_abnormal_enzyme/_coenzyme0.82145465
54MP0001533_abnormal_skeleton_physiology0.81434651
55MP0002398_abnormal_bone_marrow0.81106964
56MP0005503_abnormal_tendon_morphology0.80687231
57MP0004142_abnormal_muscle_tone0.80517198
58MP0005379_endocrine/exocrine_gland_phen0.77560660
59MP0001881_abnormal_mammary_gland0.77487323
60MP0009780_abnormal_chondrocyte_physiolo0.77257478
61MP0001986_abnormal_taste_sensitivity0.75001278
62MP0002234_abnormal_pharynx_morphology0.72251100
63MP0005551_abnormal_eye_electrophysiolog0.71194762
64MP0002108_abnormal_muscle_morphology0.69957573
65MP0002723_abnormal_immune_serum0.69468932
66MP0003567_abnormal_fetal_cardiomyocyte0.67684444
67MP0000049_abnormal_middle_ear0.67234466
68MP0005646_abnormal_pituitary_gland0.66723289
69MP0004742_abnormal_vestibular_system0.64612699
70MP0004130_abnormal_muscle_cell0.63459759
71MP0001544_abnormal_cardiovascular_syste0.61250114
72MP0005385_cardiovascular_system_phenoty0.61250114
73MP0008872_abnormal_physiological_respon0.61212421
74MP0005410_abnormal_fertilization0.61146534
75MP0002210_abnormal_sex_determination0.59208230
76MP0001542_abnormal_bone_strength0.59044300
77MP0001853_heart_inflammation0.58666440
78MP0003183_abnormal_peptide_metabolism0.56635635
79MP0005381_digestive/alimentary_phenotyp0.56147901
80MP0008469_abnormal_protein_level0.56128688
81MP0005369_muscle_phenotype0.55342090
82MP0000689_abnormal_spleen_morphology0.54589170
83MP0005000_abnormal_immune_tolerance0.54326785
84MP0003436_decreased_susceptibility_to0.54317770
85MP0002405_respiratory_system_inflammati0.53508059
86MP0000733_abnormal_muscle_development0.53371570
87MP0000703_abnormal_thymus_morphology0.53166085
88MP0004947_skin_inflammation0.52978417
89MP0001919_abnormal_reproductive_system0.51632651
90MP0002420_abnormal_adaptive_immunity0.51506344
91MP0002106_abnormal_muscle_physiology0.51364906
92MP0001963_abnormal_hearing_physiology0.50901601
93MP0004957_abnormal_blastocyst_morpholog0.50550407
94MP0002722_abnormal_immune_system0.50481090
95MP0002429_abnormal_blood_cell0.50166061
96MP0010155_abnormal_intestine_physiology0.48653992
97MP0005197_abnormal_uvea_morphology0.47998087
98MP0008775_abnormal_heart_ventricle0.47307893
99MP0004084_abnormal_cardiac_muscle0.47195278
100MP0006276_abnormal_autonomic_nervous0.46587522

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)7.20572293
2Abnormality of macular pigmentation (HP:0008002)5.59087579
3Hypobetalipoproteinemia (HP:0003563)5.38548867
4Akinesia (HP:0002304)5.28047993
5Abnormality of the phalanges of the 2nd finger (HP:0009541)5.10813224
6Striae distensae (HP:0001065)5.04534012
7Acanthocytosis (HP:0001927)4.82900185
8Metaphyseal cupping (HP:0003021)4.79993473
9Constricted visual fields (HP:0001133)4.79799666
10Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.78057949
11Round ear (HP:0100830)4.65000009
12Cupped ribs (HP:0000887)4.50813556
13Volvulus (HP:0002580)4.47949007
14Decreased muscle mass (HP:0003199)4.38446570
15Neurodegeneration (HP:0002180)4.11578532
16Brushfield spots (HP:0001088)4.03876665
17Dyskinesia (HP:0100660)3.98979981
18Cone-rod dystrophy (HP:0000548)3.89035508
19Decreased electroretinogram (ERG) amplitude (HP:0000654)3.79488320
20Toxemia of pregnancy (HP:0100603)3.59835872
21Attenuation of retinal blood vessels (HP:0007843)3.53990662
22Abnormality of the 2nd finger (HP:0004100)3.49215965
23Hyperglycinemia (HP:0002154)3.48034769
24Diminished movement (HP:0002374)3.44008879
25Patent foramen ovale (HP:0001655)3.39911860
26Methylmalonic acidemia (HP:0002912)3.21853695
27Alkalosis (HP:0001948)2.98723836
28Large earlobe (HP:0009748)2.98182780
29Amblyopia (HP:0000646)2.93546789
30Congenital sensorineural hearing impairment (HP:0008527)2.81582153
31Broad nasal tip (HP:0000455)2.75324558
32Hemiplegia (HP:0002301)2.73822780
33Large eyes (HP:0001090)2.68196128
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.62639960
35Increased circulating renin level (HP:0000848)2.60577860
36Abnormality of cells of the erythroid lineage (HP:0012130)2.59522118
37Broad distal phalanx of finger (HP:0009836)2.58464725
38Hypolipoproteinemia (HP:0010981)2.48544936
39Microretrognathia (HP:0000308)2.48158814
40Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.47947047
41Dysphonia (HP:0001618)2.45286557
42Abnormality of fatty-acid metabolism (HP:0004359)2.44516928
43Abnormality of vitamin B metabolism (HP:0004340)2.42650418
44Aplasia/Hypoplasia of the earlobes (HP:0009906)2.40725684
45Macrocytic anemia (HP:0001972)2.39040084
46Tubulointerstitial nephritis (HP:0001970)2.33652414
47Pallor (HP:0000980)2.30272100
48Progressive muscle weakness (HP:0003323)2.28734242
49Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.25109096
50Oligodontia (HP:0000677)2.23245781
51Tibial bowing (HP:0002982)2.22205022
52Abnormality of the middle phalanges of the toes (HP:0010183)2.22072513
53Tetany (HP:0001281)2.21439955
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19519331
55Mild short stature (HP:0003502)2.19115677
56Paralysis (HP:0003470)2.19023203
57Methylmalonic aciduria (HP:0012120)2.17685237
58Limited elbow extension (HP:0001377)2.09099085
59Bicuspid aortic valve (HP:0001647)2.08253351
60Lack of skin elasticity (HP:0100679)2.05542196
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05308803
62Abnormality of alanine metabolism (HP:0010916)2.05308803
63Hyperalaninemia (HP:0003348)2.05308803
64Epiphyseal stippling (HP:0010655)2.03284232
65Abnormality of the phalanges of the 5th finger (HP:0004213)2.01974496
66Hypomagnesemia (HP:0002917)2.01829580
67Ovoid vertebral bodies (HP:0003300)2.01549631
68Poikilocytosis (HP:0004447)2.00850897
69Cerebral edema (HP:0002181)2.00657251
70Abnormality of the basal ganglia (HP:0002134)2.00169806
71Hypokalemic alkalosis (HP:0001949)1.98861726
72Increased CSF lactate (HP:0002490)1.98105775
73Femoral bowing (HP:0002980)1.94084395
74Abnormality of serum amino acid levels (HP:0003112)1.92746427
75Hyperthyroidism (HP:0000836)1.91531933
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91179896
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91179896
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87508540
79Increased intramyocellular lipid droplets (HP:0012240)1.86998862
80Abnormality of the nasal septum (HP:0000419)1.84014508
81Congenital stationary night blindness (HP:0007642)1.83486113
82Abnormality of magnesium homeostasis (HP:0004921)1.83294600
83Female pseudohermaphroditism (HP:0010458)1.82849010
84CNS demyelination (HP:0007305)1.80482605
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76735671
86Concave nail (HP:0001598)1.76414564
87Mitochondrial inheritance (HP:0001427)1.73390878
88Abnormality of renin-angiotensin system (HP:0000847)1.72778494
89Stenosis of the external auditory canal (HP:0000402)1.71432030
90Partial duplication of the phalanx of hand (HP:0009999)1.70315749
91Abnormality of homocysteine metabolism (HP:0010919)1.68893001
92Homocystinuria (HP:0002156)1.68893001
93Elevated erythrocyte sedimentation rate (HP:0003565)1.68171392
94Radioulnar synostosis (HP:0002974)1.68125415
95Impaired smooth pursuit (HP:0007772)1.68066959
96Renal tubular dysfunction (HP:0000124)1.67646772
97Hepatocellular necrosis (HP:0001404)1.67168676
98Abnormal mitochondria in muscle tissue (HP:0008316)1.66962084
99Impulsivity (HP:0100710)1.64074820
100Congenital, generalized hypertrichosis (HP:0004540)1.63645220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK29.32654540
2KIT5.09127687
3WNK43.62760220
4FES3.22585617
5STK392.94047474
6ERN12.84693835
7TEC2.67115564
8OXSR12.08559678
9MAP2K62.01826460
10MAP4K11.65208750
11TLK11.62179879
12NEK21.59114064
13TXK1.56533016
14TESK21.50135452
15IKBKB1.41055656
16SYK1.36665615
17INSRR1.36054633
18BMPR21.28358506
19ACVR1B1.27320365
20NEK61.23377750
21RPS6KB21.23372046
22FRK1.22622054
23MST1R1.20663748
24NME21.16373798
25AKT31.14351314
26PIM11.07918987
27PLK41.03335701
28MAP4K21.02049751
29SIK20.99862624
30LCK0.99000477
31TYRO30.98883526
32AKT20.96502830
33CSK0.94376124
34STK380.93598618
35MUSK0.92067519
36BMPR1B0.91301310
37TGFBR10.88732780
38RET0.87430868
39MAP2K20.83252239
40BCKDK0.82832620
41GRK10.81323284
42ABL20.76824300
43CAMKK20.76688177
44PDPK10.75384131
45MAPK120.74598029
46ADRBK10.73253333
47PIM20.71023188
48ZAK0.70599585
49OBSCN0.70083029
50INSR0.69723743
51PKN10.69226338
52PDK10.65480632
53PASK0.64864012
54CDK30.64613580
55PBK0.63186452
56ADRBK20.60788846
57IKBKE0.59357141
58BTK0.56286092
59PRKACA0.54195249
60MAPK150.48457815
61RPS6KA50.48234442
62MAPK70.48200256
63MAPK100.46217886
64PIK3CG0.45380081
65CSF1R0.45171841
66PRKCA0.43593815
67BRD40.42669815
68PRKACG0.39899922
69RPS6KA60.38803003
70EGFR0.37714814
71MAP2K10.37420563
72CDK20.36735137
73GRK60.36592767
74GRK70.33900268
75RPS6KC10.33613911
76RPS6KL10.33613911
77PRKCQ0.33597835
78CAMK2A0.33207518
79RPS6KA10.33188793
80MAP3K60.33186045
81ZAP700.33090754
82ABL10.33080822
83AURKA0.32408839
84JAK30.31747358
85RPS6KB10.31462749
86TRPM70.30849962
87TBK10.30755539
88STK110.30746068
89CSNK2A10.29963207
90ATR0.29949020
91FGR0.28843512
92PDGFRB0.28343356
93TIE10.26270540
94WNK30.26182282
95PRKG20.26157016
96MAP2K30.25481664
97LYN0.25025922
98AKT10.24711928
99ATM0.24639369
100CDK190.24524476

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.50539895
2Sulfur metabolism_Homo sapiens_hsa009204.08388549
3Oxidative phosphorylation_Homo sapiens_hsa001903.55902014
4Parkinsons disease_Homo sapiens_hsa050122.93510758
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.64208336
6Nitrogen metabolism_Homo sapiens_hsa009102.53129123
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24339686
8Fructose and mannose metabolism_Homo sapiens_hsa000512.18588609
9Alzheimers disease_Homo sapiens_hsa050102.17624334
10Huntingtons disease_Homo sapiens_hsa050161.99964113
11Graft-versus-host disease_Homo sapiens_hsa053321.99501240
12Autoimmune thyroid disease_Homo sapiens_hsa053201.90779774
13Allograft rejection_Homo sapiens_hsa053301.88835328
14Asthma_Homo sapiens_hsa053101.78984060
15Phototransduction_Homo sapiens_hsa047441.73189170
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52633000
17Linoleic acid metabolism_Homo sapiens_hsa005911.51403129
18Mismatch repair_Homo sapiens_hsa034301.50909799
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37222716
20RNA degradation_Homo sapiens_hsa030181.31854776
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29200496
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26712516
23Arginine biosynthesis_Homo sapiens_hsa002201.26548263
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25624726
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24641579
26Cardiac muscle contraction_Homo sapiens_hsa042601.17663803
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15255215
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13391183
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11206779
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11189491
31RNA polymerase_Homo sapiens_hsa030201.09890813
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07904988
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.07581424
34Hematopoietic cell lineage_Homo sapiens_hsa046401.06926031
35Purine metabolism_Homo sapiens_hsa002301.05733124
36Proteasome_Homo sapiens_hsa030501.05562812
37Systemic lupus erythematosus_Homo sapiens_hsa053221.05293691
38Type I diabetes mellitus_Homo sapiens_hsa049401.02381780
39Selenocompound metabolism_Homo sapiens_hsa004500.97502258
40Histidine metabolism_Homo sapiens_hsa003400.97145109
41Morphine addiction_Homo sapiens_hsa050320.95567443
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93573343
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92980635
44Arachidonic acid metabolism_Homo sapiens_hsa005900.91332066
45Tryptophan metabolism_Homo sapiens_hsa003800.90488705
46Olfactory transduction_Homo sapiens_hsa047400.89978996
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85665385
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85335937
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.82740397
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82208792
51Tyrosine metabolism_Homo sapiens_hsa003500.81227427
52Taste transduction_Homo sapiens_hsa047420.79743758
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.79608177
54DNA replication_Homo sapiens_hsa030300.78202304
55Homologous recombination_Homo sapiens_hsa034400.74776774
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73617922
57Biosynthesis of amino acids_Homo sapiens_hsa012300.72004106
58Peroxisome_Homo sapiens_hsa041460.70347990
59Viral myocarditis_Homo sapiens_hsa054160.65130579
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64951190
61Pyrimidine metabolism_Homo sapiens_hsa002400.64789267
62FoxO signaling pathway_Homo sapiens_hsa040680.62999913
63Alcoholism_Homo sapiens_hsa050340.62858708
64Caffeine metabolism_Homo sapiens_hsa002320.62641460
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.62345334
66Fat digestion and absorption_Homo sapiens_hsa049750.59404572
67Nicotine addiction_Homo sapiens_hsa050330.59106632
68Metabolic pathways_Homo sapiens_hsa011000.58837548
69Regulation of autophagy_Homo sapiens_hsa041400.58592147
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51941275
71Antigen processing and presentation_Homo sapiens_hsa046120.49827621
72T cell receptor signaling pathway_Homo sapiens_hsa046600.48925425
73Retinol metabolism_Homo sapiens_hsa008300.48548907
74Malaria_Homo sapiens_hsa051440.46466068
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46056416
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.45814913
77Pyruvate metabolism_Homo sapiens_hsa006200.45184062
78Arginine and proline metabolism_Homo sapiens_hsa003300.42321552
79Ether lipid metabolism_Homo sapiens_hsa005650.41731670
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41602063
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41452777
82Fanconi anemia pathway_Homo sapiens_hsa034600.40864974
83Basal transcription factors_Homo sapiens_hsa030220.40365161
84Staphylococcus aureus infection_Homo sapiens_hsa051500.37673548
85Phenylalanine metabolism_Homo sapiens_hsa003600.36165633
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.34999723
87Sulfur relay system_Homo sapiens_hsa041220.34783231
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.34688086
89Vitamin digestion and absorption_Homo sapiens_hsa049770.34308892
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33465843
91Chemical carcinogenesis_Homo sapiens_hsa052040.32585829
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31246634
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31093111
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.30159183
95TGF-beta signaling pathway_Homo sapiens_hsa043500.29172170
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28638558
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28563076
98One carbon pool by folate_Homo sapiens_hsa006700.28474569
99Renin-angiotensin system_Homo sapiens_hsa046140.27997167
100Spliceosome_Homo sapiens_hsa030400.27754502

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