TPT1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)8.94113585
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.40408185
3regulation of isotype switching to IgG isotypes (GO:0048302)8.31161956
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.49427629
5regulation of podosome assembly (GO:0071801)7.11146424
6positive regulation of isotype switching (GO:0045830)6.18697768
7regulation of chronic inflammatory response (GO:0002676)5.47084062
8positive regulation of DNA recombination (GO:0045911)5.36513675
9chaperone-mediated protein transport (GO:0072321)5.34361526
10ribosomal small subunit assembly (GO:0000028)5.26480910
11positive regulation of immunoglobulin production (GO:0002639)5.00922660
12viral transcription (GO:0019083)4.89374312
13ribosomal small subunit biogenesis (GO:0042274)4.82467455
14translational termination (GO:0006415)4.63037437
15ribosomal large subunit biogenesis (GO:0042273)4.59675934
16positive regulation of activated T cell proliferation (GO:0042104)4.58962630
17CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.58767453
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19234759
19cotranslational protein targeting to membrane (GO:0006613)4.16598414
20glyoxylate metabolic process (GO:0046487)4.13957136
21regulation of immunoglobulin production (GO:0002637)4.08242955
22protein targeting to ER (GO:0045047)4.06496544
23translational elongation (GO:0006414)4.03883404
24ribonucleoprotein complex biogenesis (GO:0022613)3.99786317
25negative regulation of nitric oxide biosynthetic process (GO:0045019)3.98846155
26hormone catabolic process (GO:0042447)3.94321178
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92345763
28protein localization to endoplasmic reticulum (GO:0070972)3.89665313
29negative regulation of B cell apoptotic process (GO:0002903)3.88941549
30negative regulation of acute inflammatory response (GO:0002674)3.83954781
31positive regulation of interleukin-17 production (GO:0032740)3.80312821
32translation (GO:0006412)3.69087429
33regulation of isotype switching (GO:0045191)3.68724997
34GTP biosynthetic process (GO:0006183)3.68358723
35translational initiation (GO:0006413)3.65893989
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.56876661
37L-phenylalanine catabolic process (GO:0006559)3.56876661
38ribosome biogenesis (GO:0042254)3.56683464
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51992797
40cellular component biogenesis (GO:0044085)3.50495643
41negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.50402003
42negative regulation of T-helper cell differentiation (GO:0045623)3.50402003
43viral life cycle (GO:0019058)3.49340025
44regulation of regulatory T cell differentiation (GO:0045589)3.47088003
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.43896092
46positive regulation of B cell mediated immunity (GO:0002714)3.43896092
47maturation of SSU-rRNA (GO:0030490)3.43729311
48positive regulation of granulocyte differentiation (GO:0030854)3.42669834
49response to mercury ion (GO:0046689)3.41180153
50cellular protein complex disassembly (GO:0043624)3.37276696
51positive regulation of chemokine biosynthetic process (GO:0045080)3.36869529
52DNA deamination (GO:0045006)3.34099053
53regulation of triglyceride catabolic process (GO:0010896)3.32258490
54cytokine production involved in immune response (GO:0002367)3.31808628
55regulation of MHC class II biosynthetic process (GO:0045346)3.30281632
56termination of RNA polymerase I transcription (GO:0006363)3.27351844
57T-helper cell differentiation (GO:0042093)3.24828163
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.24828163
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.23689942
60UTP biosynthetic process (GO:0006228)3.20924652
61behavioral response to nicotine (GO:0035095)3.20824553
62water-soluble vitamin biosynthetic process (GO:0042364)3.18668008
63rRNA processing (GO:0006364)3.17836625
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16856912
65negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.16843237
66positive regulation of JAK-STAT cascade (GO:0046427)3.16239982
67regulation of mitochondrial translation (GO:0070129)3.12939602
68rRNA metabolic process (GO:0016072)3.12925496
69protein targeting to mitochondrion (GO:0006626)3.12662342
70positive regulation of organelle assembly (GO:1902117)3.07749993
71intracellular protein transmembrane import (GO:0044743)3.05157617
72positive regulation of B cell proliferation (GO:0030890)3.03833251
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03413966
74ATP synthesis coupled proton transport (GO:0015986)3.03413966
75rRNA modification (GO:0000154)3.02744927
76pseudouridine synthesis (GO:0001522)3.02689515
77regulation of sequestering of triglyceride (GO:0010889)2.99915823
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.98905238
79L-phenylalanine metabolic process (GO:0006558)2.96848021
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96848021
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95976809
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95976809
83isotype switching (GO:0045190)2.95976809
84positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.91240311
85rRNA methylation (GO:0031167)2.88936917
86protein targeting to membrane (GO:0006612)2.88342493
87regulation of proton transport (GO:0010155)2.86849471
88establishment of protein localization to mitochondrion (GO:0072655)2.86149861
89alpha-beta T cell differentiation involved in immune response (GO:0002293)2.84680940
90alpha-beta T cell activation involved in immune response (GO:0002287)2.84680940
91T cell differentiation involved in immune response (GO:0002292)2.84680940
92UTP metabolic process (GO:0046051)2.82760761
93regulation of retinoic acid receptor signaling pathway (GO:0048385)2.82482535
94cell wall macromolecule catabolic process (GO:0016998)2.81738594
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81133057
96regulation of activated T cell proliferation (GO:0046006)2.78966190
97base-excision repair, AP site formation (GO:0006285)2.73318334
98oxidative demethylation (GO:0070989)2.72735404
99protein complex disassembly (GO:0043241)2.70753470
100protein localization to mitochondrion (GO:0070585)2.67439099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85577666
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.62812846
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25107934
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53878460
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.28215361
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.13530361
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98273469
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.96173869
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87380795
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54874691
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46141102
12TP53_22573176_ChIP-Seq_HFKS_Human2.18364131
13VDR_23849224_ChIP-Seq_CD4+_Human2.16634438
14EZH2_22144423_ChIP-Seq_EOC_Human2.09879418
15FOXP3_21729870_ChIP-Seq_TREG_Human2.07556776
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06744221
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03782993
18ZNF274_21170338_ChIP-Seq_K562_Hela2.02577963
19TTF2_22483619_ChIP-Seq_HELA_Human2.01261497
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.87491646
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86633360
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82146801
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76062463
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75017065
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72049512
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70673972
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68038113
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66962225
29DCP1A_22483619_ChIP-Seq_HELA_Human1.63308902
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60406742
31MYC_18940864_ChIP-ChIP_HL60_Human1.57211113
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.54149664
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52347416
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48737757
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47817924
36VDR_22108803_ChIP-Seq_LS180_Human1.46725596
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.45665552
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42216369
39NANOG_20526341_ChIP-Seq_ESCs_Human1.41717824
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37081194
41EWS_26573619_Chip-Seq_HEK293_Human1.36619187
42GABP_19822575_ChIP-Seq_HepG2_Human1.34912314
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34367959
44ELK1_19687146_ChIP-ChIP_HELA_Human1.34114589
45ERA_21632823_ChIP-Seq_H3396_Human1.32915848
46PHF8_20622853_ChIP-Seq_HELA_Human1.32250484
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31637908
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31064626
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30427638
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25924050
51GATA3_21867929_ChIP-Seq_TH1_Mouse1.24980751
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.23309583
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.21687480
54TAF2_19829295_ChIP-Seq_ESCs_Human1.20815576
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19969915
56HTT_18923047_ChIP-ChIP_STHdh_Human1.19736523
57GATA3_26560356_Chip-Seq_TH2_Human1.19514492
58NCOR_22424771_ChIP-Seq_293T_Human1.18186343
59SA1_27219007_Chip-Seq_Bcells_Human1.17601535
60RBPJ_21746931_ChIP-Seq_IB4_Human1.17248630
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.16751293
62XRN2_22483619_ChIP-Seq_HELA_Human1.15757752
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15311578
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13679963
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11523696
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10150363
67NFYB_21822215_ChIP-Seq_K562_Human1.09700635
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.08431785
69P53_21459846_ChIP-Seq_SAOS-2_Human1.06229052
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06190329
71NANOG_19829295_ChIP-Seq_ESCs_Human1.03826332
72SOX2_19829295_ChIP-Seq_ESCs_Human1.03826332
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.03172532
74ETV1_20927104_ChIP-Seq_GIST48_Human1.02297105
75TAF15_26573619_Chip-Seq_HEK293_Human1.02000582
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01201340
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00167573
78NFYA_21822215_ChIP-Seq_K562_Human0.99366517
79CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98711456
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98137459
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.97520223
82MYC_19829295_ChIP-Seq_ESCs_Human0.97511217
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96888733
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95665402
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95058150
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94938469
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.94938469
88FUS_26573619_Chip-Seq_HEK293_Human0.94430926
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94114329
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93425879
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91800636
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91593278
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91307359
94CTCF_20526341_ChIP-Seq_ESCs_Human0.90256953
95SOX2_21211035_ChIP-Seq_LN229_Human0.89182953
96SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88840591
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88397458
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88357970
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87495477
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87321710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.72336466
2MP0008875_abnormal_xenobiotic_pharmacok3.85294091
3MP0009379_abnormal_foot_pigmentation3.77604049
4MP0001348_abnormal_lacrimal_gland3.50699366
5MP0001835_abnormal_antigen_presentation3.23616657
6MP0003806_abnormal_nucleotide_metabolis3.03784296
7MP0001873_stomach_inflammation2.80130112
8MP0000569_abnormal_digit_pigmentation2.55477214
9MP0005408_hypopigmentation2.40702177
10MP0009697_abnormal_copulation2.39120066
11MP0002139_abnormal_hepatobiliary_system2.35919605
12MP0002876_abnormal_thyroid_physiology2.34015378
13MP0008872_abnormal_physiological_respon2.28152686
14MP0005174_abnormal_tail_pigmentation2.25135269
15MP0001188_hyperpigmentation2.20862361
16MP0002938_white_spotting2.15196464
17MP0000604_amyloidosis2.10955689
18MP0008877_abnormal_DNA_methylation2.10216064
19MP0004142_abnormal_muscle_tone2.09771594
20MP0005085_abnormal_gallbladder_physiolo2.03642954
21MP0008058_abnormal_DNA_repair2.01364757
22MP0006082_CNS_inflammation1.97355181
23MP0003195_calcinosis1.97315188
24MP0006292_abnormal_olfactory_placode1.97292322
25MP0003186_abnormal_redox_activity1.92789217
26MP0003786_premature_aging1.92344778
27MP0001764_abnormal_homeostasis1.87594946
28MP0002160_abnormal_reproductive_system1.63881791
29MP0009333_abnormal_splenocyte_physiolog1.61966838
30MP0005645_abnormal_hypothalamus_physiol1.60495359
31MP0001968_abnormal_touch/_nociception1.60089061
32MP0001986_abnormal_taste_sensitivity1.60060957
33MP0000685_abnormal_immune_system1.59162070
34MP0001853_heart_inflammation1.53010535
35MP0002163_abnormal_gland_morphology1.50132929
36MP0005360_urolithiasis1.49081632
37MP0003300_gastrointestinal_ulcer1.47622678
38MP0005075_abnormal_melanosome_morpholog1.35505296
39MP0004147_increased_porphyrin_level1.31852922
40MP0005646_abnormal_pituitary_gland1.31022523
41MP0001542_abnormal_bone_strength1.29017317
42MP0003122_maternal_imprinting1.25283291
43MP0005389_reproductive_system_phenotype1.24888585
44MP0002736_abnormal_nociception_after1.23580242
45MP0005387_immune_system_phenotype1.23359196
46MP0001790_abnormal_immune_system1.23359196
47MP0008789_abnormal_olfactory_epithelium1.21925062
48MP0002837_dystrophic_cardiac_calcinosis1.20431686
49MP0003718_maternal_effect1.13249564
50MP0005501_abnormal_skin_physiology1.11311459
51MP0005332_abnormal_amino_acid1.10297835
52MP0005551_abnormal_eye_electrophysiolog1.09650900
53MP0003136_yellow_coat_color1.08300825
54MP0006036_abnormal_mitochondrial_physio1.07125139
55MP0005379_endocrine/exocrine_gland_phen1.05209780
56MP0000015_abnormal_ear_pigmentation1.04750551
57MP0005671_abnormal_response_to1.03845931
58MP0001881_abnormal_mammary_gland1.03714257
59MP0005410_abnormal_fertilization1.03592201
60MP0010329_abnormal_lipoprotein_level1.03146943
61MP0002277_abnormal_respiratory_mucosa1.02505923
62MP0002095_abnormal_skin_pigmentation1.01554217
63MP0005636_abnormal_mineral_homeostasis1.01481685
64MP0002148_abnormal_hypersensitivity_rea1.01067493
65MP0003868_abnormal_feces_composition1.00634332
66MP0000372_irregular_coat_pigmentation0.94993749
67MP0006035_abnormal_mitochondrial_morpho0.93232216
68MP0001800_abnormal_humoral_immune0.91408163
69MP0004043_abnormal_pH_regulation0.90956076
70MP0003252_abnormal_bile_duct0.90918332
71MP0005310_abnormal_salivary_gland0.88553545
72MP0003879_abnormal_hair_cell0.87691375
73MP0010386_abnormal_urinary_bladder0.86119947
74MP0002102_abnormal_ear_morphology0.77501493
75MP0002272_abnormal_nervous_system0.76637635
76MP0004742_abnormal_vestibular_system0.76561495
77MP0006276_abnormal_autonomic_nervous0.75860002
78MP0000490_abnormal_crypts_of0.75094425
79MP0006072_abnormal_retinal_apoptosis0.74333559
80MP0004885_abnormal_endolymph0.74277355
81MP0003121_genomic_imprinting0.73123929
82MP0005319_abnormal_enzyme/_coenzyme0.72882713
83MP0000427_abnormal_hair_cycle0.72494250
84MP0009745_abnormal_behavioral_response0.72307982
85MP0000049_abnormal_middle_ear0.71999446
86MP0002733_abnormal_thermal_nociception0.70388878
87MP0003329_amyloid_beta_deposits0.69208852
88MP0005084_abnormal_gallbladder_morpholo0.68016163
89MP0001663_abnormal_digestive_system0.67470383
90MP0001502_abnormal_circadian_rhythm0.65069697
91MP0004145_abnormal_muscle_electrophysio0.65069661
92MP0003191_abnormal_cellular_cholesterol0.64243242
93MP0000465_gastrointestinal_hemorrhage0.63652426
94MP0004019_abnormal_vitamin_homeostasis0.62697618
95MP0003567_abnormal_fetal_cardiomyocyte0.62112434
96MP0002557_abnormal_social/conspecific_i0.61689575
97MP0009643_abnormal_urine_homeostasis0.60545637
98MP0005365_abnormal_bile_salt0.59832855
99MP0003638_abnormal_response/metabolism_0.59680515
100MP0008873_increased_physiological_sensi0.57061408

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.86632874
2Reticulocytopenia (HP:0001896)4.20946997
3Acute necrotizing encephalopathy (HP:0006965)4.04531661
4Abnormal biliary tract physiology (HP:0012439)4.01524515
5Bile duct proliferation (HP:0001408)4.01524515
6Entropion (HP:0000621)3.90281653
7Congenital, generalized hypertrichosis (HP:0004540)3.68881642
8Acute encephalopathy (HP:0006846)3.55889802
9Abnormal mitochondria in muscle tissue (HP:0008316)3.46975493
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33319258
11Progressive macrocephaly (HP:0004481)3.32754468
12Increased CSF lactate (HP:0002490)3.14117766
13Mitochondrial inheritance (HP:0001427)3.12494221
14Increased hepatocellular lipid droplets (HP:0006565)3.11084378
15Increased IgM level (HP:0003496)3.06048823
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05762432
17Progressive muscle weakness (HP:0003323)3.02999409
18Cerebral edema (HP:0002181)2.94830638
19Microvesicular hepatic steatosis (HP:0001414)2.94207584
20Abnormality of DNA repair (HP:0003254)2.91116890
21Asplenia (HP:0001746)2.85233809
223-Methylglutaconic aciduria (HP:0003535)2.85079227
23Pendular nystagmus (HP:0012043)2.84038274
24Aplasia/Hypoplasia of the spleen (HP:0010451)2.81066309
25Aplasia/hypoplasia of the uterus (HP:0008684)2.79411690
26Abnormal rod and cone electroretinograms (HP:0008323)2.78271956
27Type 2 muscle fiber atrophy (HP:0003554)2.68108087
28Aplastic anemia (HP:0001915)2.65421254
29Lipid accumulation in hepatocytes (HP:0006561)2.62389143
30IgG deficiency (HP:0004315)2.60436983
31Pancreatic fibrosis (HP:0100732)2.58513804
32Pancreatic cysts (HP:0001737)2.55509559
33Poikiloderma (HP:0001029)2.54343537
34Optic disc pallor (HP:0000543)2.49475182
35Macrocytic anemia (HP:0001972)2.48351765
36Fair hair (HP:0002286)2.48068549
37Hypoplasia of the uterus (HP:0000013)2.44276122
38Delayed CNS myelination (HP:0002188)2.42327921
39Lethargy (HP:0001254)2.40803770
40Renal Fanconi syndrome (HP:0001994)2.40610203
41Impaired proprioception (HP:0010831)2.39577854
42Large for gestational age (HP:0001520)2.38201135
43Increased serum lactate (HP:0002151)2.37227433
44Fibular aplasia (HP:0002990)2.36990551
45Type II lissencephaly (HP:0007260)2.33839535
46Exertional dyspnea (HP:0002875)2.33705629
47Abnormal pupillary function (HP:0007686)2.32271792
48Tubular atrophy (HP:0000092)2.30186338
49Abnormality of magnesium homeostasis (HP:0004921)2.29716645
50Congenital stationary night blindness (HP:0007642)2.27297484
51Sensorimotor neuropathy (HP:0007141)2.26714368
52Bony spicule pigmentary retinopathy (HP:0007737)2.24248550
53Carpal bone hypoplasia (HP:0001498)2.22948302
54Abnormality of pyrimidine metabolism (HP:0004353)2.21995624
55Hyperphosphaturia (HP:0003109)2.21772294
56Muscle fiber atrophy (HP:0100295)2.21416774
57Increased intramyocellular lipid droplets (HP:0012240)2.19524344
58Paralysis (HP:0003470)2.17801803
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17102549
60Lactic acidosis (HP:0003128)2.15346131
61Polydipsia (HP:0001959)2.15303980
62Abnormal drinking behavior (HP:0030082)2.15303980
63Growth hormone deficiency (HP:0000824)2.14625753
64Absent thumb (HP:0009777)2.14604958
65Hypophosphatemic rickets (HP:0004912)2.13902276
66Epiphyseal stippling (HP:0010655)2.12921570
67Abnormal epiphyseal ossification (HP:0010656)2.09866311
68Respiratory difficulties (HP:0002880)2.09204530
69Exercise intolerance (HP:0003546)2.08495311
70Vacuolated lymphocytes (HP:0001922)2.03493073
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03240821
72Abnormal trabecular bone morphology (HP:0100671)2.02983075
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02131346
74Glycosuria (HP:0003076)2.01120499
75Abnormality of urine glucose concentration (HP:0011016)2.01120499
76Stenosis of the external auditory canal (HP:0000402)1.99055492
77Delayed epiphyseal ossification (HP:0002663)1.98750580
78Keratoconus (HP:0000563)1.98201717
79Increased corneal curvature (HP:0100692)1.98201717
80Colon cancer (HP:0003003)1.96943097
81Abnormal hair whorl (HP:0010721)1.96493914
82Abnormality of cells of the erythroid lineage (HP:0012130)1.94510510
83Abnormal urine phosphate concentration (HP:0012599)1.93986883
84Aplasia/Hypoplasia of the ulna (HP:0006495)1.93281468
85Partial agenesis of the corpus callosum (HP:0001338)1.92547726
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90970920
87Abnormality of alanine metabolism (HP:0010916)1.90970920
88Hyperalaninemia (HP:0003348)1.90970920
89Methylmalonic aciduria (HP:0012120)1.89207483
90Enlarged epiphyses (HP:0010580)1.87870602
91Hypoplasia of the ulna (HP:0003022)1.84985671
92Neutropenia (HP:0001875)1.83774690
93Constricted visual fields (HP:0001133)1.83713571
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82674564
95Osteomalacia (HP:0002749)1.81868373
96Broad-based gait (HP:0002136)1.81801438
97Elevated erythrocyte sedimentation rate (HP:0003565)1.80746249
98Polyuria (HP:0000103)1.80387781
99Fatigue (HP:0012378)1.79476919
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.77249631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.83807808
2PBK5.76507446
3WNK44.17815595
4EIF2AK12.69745780
5ADRBK22.67982642
6NEK12.46788188
7PIK3CG2.35915923
8STK392.29332756
9BCKDK2.01039677
10TSSK61.98147815
11MST41.93939583
12DYRK21.84990471
13NME11.81044642
14NUAK11.73177320
15GRK11.64495304
16SRPK11.59638074
17MAP3K121.57224595
18PHKG11.43729673
19PHKG21.43729673
20OXSR11.38756910
21PDK21.37870121
22PASK1.31480508
23WNK11.27904424
24MAP4K21.26819830
25STK41.26816271
26EIF2AK31.25013188
27TLK11.21075160
28ZAK1.13854853
29CDK191.08854311
30DYRK31.06562406
31BUB11.01420633
32ITK1.01344568
33TEC0.97231228
34NME20.95549856
35TXK0.95148231
36WNK30.85883207
37PRKCQ0.85571177
38MKNK20.81117297
39MAP3K110.80958791
40CSK0.77043406
41TAOK30.75159216
42STK38L0.72712029
43TGFBR10.69989857
44RPS6KA60.66590534
45PRKD30.66346322
46AURKB0.64802166
47PLK10.64696501
48RPS6KA10.60946672
49BRAF0.60811555
50PLK40.59180508
51INSRR0.58485994
52OBSCN0.56243953
53BRD40.55732450
54TNIK0.53910709
55PRKCG0.53433564
56IKBKB0.51386277
57CSNK2A20.51255846
58RPS6KL10.50727901
59RPS6KC10.50727901
60TIE10.49870054
61IKBKE0.49706370
62CHEK10.48396024
63TYRO30.47657510
64FGFR10.47269389
65BMPR1B0.47169167
66KIT0.46649940
67NEK20.45797135
68AKT20.44630604
69MELK0.44175403
70RPS6KB20.44011310
71MAPK130.43960004
72ATR0.43592442
73MET0.43075756
74EPHB20.40634314
75MKNK10.40327387
76CCNB10.40070833
77AURKA0.38872498
78CDC70.38034997
79FES0.37081978
80VRK10.36994462
81ADRBK10.36132817
82ABL20.35588001
83SGK10.35460130
84CAMK10.35391376
85CSNK1G20.35121412
86PLK30.34862878
87CSNK1A10.34394797
88PRKACA0.34382009
89PNCK0.33446736
90PRKG10.32937013
91STK30.32400969
92MUSK0.31944596
93CSNK1E0.30447478
94CSNK2A10.29577430
95LCK0.29566643
96DAPK20.29244231
97PIM10.28258779
98RAF10.28254138
99TNK20.27927054
100PRKCE0.27440997

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.65149390
2Ribosome_Homo sapiens_hsa030104.62197063
3Allograft rejection_Homo sapiens_hsa053303.79471955
4Autoimmune thyroid disease_Homo sapiens_hsa053203.60233346
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.10634052
6Proteasome_Homo sapiens_hsa030502.58742493
7Oxidative phosphorylation_Homo sapiens_hsa001902.50183417
8Basal transcription factors_Homo sapiens_hsa030222.45295010
9Protein export_Homo sapiens_hsa030602.33844490
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21632207
11Parkinsons disease_Homo sapiens_hsa050122.10420089
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06442147
13RNA polymerase_Homo sapiens_hsa030202.01939994
14Peroxisome_Homo sapiens_hsa041461.82746267
15Vitamin B6 metabolism_Homo sapiens_hsa007501.82442998
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78396819
17Nitrogen metabolism_Homo sapiens_hsa009101.53289333
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48821208
19Sulfur metabolism_Homo sapiens_hsa009201.47715703
20Linoleic acid metabolism_Homo sapiens_hsa005911.46769314
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45120159
22Nucleotide excision repair_Homo sapiens_hsa034201.44523182
23One carbon pool by folate_Homo sapiens_hsa006701.40927938
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40618702
25Huntingtons disease_Homo sapiens_hsa050161.36496774
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33016376
27Alzheimers disease_Homo sapiens_hsa050101.31970494
28Steroid biosynthesis_Homo sapiens_hsa001001.31608193
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.30838260
30RNA degradation_Homo sapiens_hsa030181.25761865
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24421475
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.19663080
33Pyrimidine metabolism_Homo sapiens_hsa002401.10391472
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07254023
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05814761
36Phototransduction_Homo sapiens_hsa047441.05631082
37Hematopoietic cell lineage_Homo sapiens_hsa046401.04087776
38Caffeine metabolism_Homo sapiens_hsa002321.01897290
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.01308163
40Base excision repair_Homo sapiens_hsa034101.00460498
41Retinol metabolism_Homo sapiens_hsa008301.00082855
42Sulfur relay system_Homo sapiens_hsa041220.99895672
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99043758
44T cell receptor signaling pathway_Homo sapiens_hsa046600.98529290
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98271369
46Cardiac muscle contraction_Homo sapiens_hsa042600.97591221
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97043114
48Glutathione metabolism_Homo sapiens_hsa004800.94989046
49Arachidonic acid metabolism_Homo sapiens_hsa005900.94490631
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94022622
51RNA transport_Homo sapiens_hsa030130.94000327
52Primary immunodeficiency_Homo sapiens_hsa053400.92900785
53DNA replication_Homo sapiens_hsa030300.91890443
54Chemical carcinogenesis_Homo sapiens_hsa052040.91391703
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85734246
56Mismatch repair_Homo sapiens_hsa034300.85695456
57beta-Alanine metabolism_Homo sapiens_hsa004100.84934598
58Homologous recombination_Homo sapiens_hsa034400.84089547
59Graft-versus-host disease_Homo sapiens_hsa053320.83069939
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82465491
61Propanoate metabolism_Homo sapiens_hsa006400.74943603
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73439205
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72972076
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.71592213
65Type I diabetes mellitus_Homo sapiens_hsa049400.63167595
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.60864747
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.59811880
68Ovarian steroidogenesis_Homo sapiens_hsa049130.58076064
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57808542
70Fatty acid degradation_Homo sapiens_hsa000710.57441317
71Ether lipid metabolism_Homo sapiens_hsa005650.55562073
72Folate biosynthesis_Homo sapiens_hsa007900.55155318
73Metabolic pathways_Homo sapiens_hsa011000.52187193
74Arginine and proline metabolism_Homo sapiens_hsa003300.51252186
75Phenylalanine metabolism_Homo sapiens_hsa003600.51151865
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50408092
77Purine metabolism_Homo sapiens_hsa002300.48813106
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47796804
79Regulation of autophagy_Homo sapiens_hsa041400.45088319
80Spliceosome_Homo sapiens_hsa030400.44310687
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43089778
82Pyruvate metabolism_Homo sapiens_hsa006200.41590427
83Tryptophan metabolism_Homo sapiens_hsa003800.41031480
84Rheumatoid arthritis_Homo sapiens_hsa053230.40130561
85Bile secretion_Homo sapiens_hsa049760.39619677
86Fat digestion and absorption_Homo sapiens_hsa049750.39465439
87Fanconi anemia pathway_Homo sapiens_hsa034600.38097324
88Vitamin digestion and absorption_Homo sapiens_hsa049770.36692410
89Complement and coagulation cascades_Homo sapiens_hsa046100.35909861
90Fatty acid biosynthesis_Homo sapiens_hsa000610.35361844
91Olfactory transduction_Homo sapiens_hsa047400.32458141
92Arginine biosynthesis_Homo sapiens_hsa002200.31558136
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31343949
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31108062
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.30554506
96Dorso-ventral axis formation_Homo sapiens_hsa043200.28408429
97PPAR signaling pathway_Homo sapiens_hsa033200.28099689
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24414855
99Mineral absorption_Homo sapiens_hsa049780.24371798
100Starch and sucrose metabolism_Homo sapiens_hsa005000.22889983

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