TPT1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)8.30811533
2regulation of sister chromatid cohesion (GO:0007063)7.26148230
3viral transcription (GO:0019083)6.04872009
4negative regulation of Ras GTPase activity (GO:0034261)5.92503833
5inositol phosphate dephosphorylation (GO:0046855)5.83545754
6phosphorylated carbohydrate dephosphorylation (GO:0046838)5.83545754
7ribosomal small subunit assembly (GO:0000028)5.78687908
8translational termination (GO:0006415)5.75211151
9ribosomal large subunit biogenesis (GO:0042273)5.67413925
10regulation of interleukin-12 biosynthetic process (GO:0045075)5.60606501
11histone H4 deacetylation (GO:0070933)5.32791163
122-oxoglutarate metabolic process (GO:0006103)5.22716324
13regulation of G0 to G1 transition (GO:0070316)5.22119916
14inositol phosphate catabolic process (GO:0071545)5.13232636
15translational elongation (GO:0006414)5.04623098
16protein import into peroxisome matrix (GO:0016558)5.01630218
17regulation of regulatory T cell differentiation (GO:0045589)4.95303696
18phosphatidylglycerol biosynthetic process (GO:0006655)4.90443995
19ribonucleoprotein complex biogenesis (GO:0022613)4.86578953
20regulation of energy homeostasis (GO:2000505)4.70454327
21primary alcohol catabolic process (GO:0034310)4.67279098
22viral life cycle (GO:0019058)4.60914335
23cellular protein complex disassembly (GO:0043624)4.53170722
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51160771
25response to muscle activity (GO:0014850)4.43834328
26cotranslational protein targeting to membrane (GO:0006613)4.42649079
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.41273719
28protein targeting to ER (GO:0045047)4.38711148
29DNA synthesis involved in DNA repair (GO:0000731)4.37089282
30positive regulation of Notch signaling pathway (GO:0045747)4.34819830
31cardiolipin metabolic process (GO:0032048)4.32153693
32tricarboxylic acid metabolic process (GO:0072350)4.24786960
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14371942
34protein localization to endoplasmic reticulum (GO:0070972)4.12868619
35histone H3 deacetylation (GO:0070932)4.10108901
36negative regulation of phagocytosis (GO:0050765)4.07669652
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04802039
38GMP metabolic process (GO:0046037)4.02193846
39adaptation of signaling pathway (GO:0023058)3.97438566
40pyrimidine nucleoside salvage (GO:0043097)3.92317945
41pyrimidine-containing compound salvage (GO:0008655)3.92317945
42mitochondrion distribution (GO:0048311)3.91043567
43positive regulation of RNA splicing (GO:0033120)3.90329683
44regulation of gamma-delta T cell differentiation (GO:0045586)3.87522714
45activated T cell proliferation (GO:0050798)3.84158078
46response to vitamin D (GO:0033280)3.77350638
47kidney morphogenesis (GO:0060993)3.74253777
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72275500
49regulation of cholesterol biosynthetic process (GO:0045540)3.71977999
50protein complex disassembly (GO:0043241)3.70383420
51positive regulation of chemokine secretion (GO:0090197)3.65695818
52phosphatidylcholine biosynthetic process (GO:0006656)3.59137463
53response to histamine (GO:0034776)3.58651291
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.49798447
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49198095
56cellular component biogenesis (GO:0044085)3.45846687
57macromolecular complex disassembly (GO:0032984)3.39066619
58maturation of SSU-rRNA (GO:0030490)3.38720546
59prostaglandin biosynthetic process (GO:0001516)3.37288476
60prostanoid biosynthetic process (GO:0046457)3.37288476
61cardiovascular system development (GO:0072358)3.33514308
62lymph node development (GO:0048535)3.32836840
63detection of mechanical stimulus (GO:0050982)3.31684544
64detection of mechanical stimulus involved in sensory perception (GO:0050974)3.31048633
65translational initiation (GO:0006413)3.25921675
66production of molecular mediator involved in inflammatory response (GO:0002532)3.25208383
67RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.21231381
68polyol catabolic process (GO:0046174)3.21195627
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18608833
70positive regulation of macrophage activation (GO:0043032)3.18595969
71negative regulation of GTP catabolic process (GO:0033125)3.18351860
72negative regulation of GTPase activity (GO:0034260)3.18351860
73ethanol metabolic process (GO:0006067)3.17696141
74protein targeting to peroxisome (GO:0006625)3.12080033
75establishment of protein localization to peroxisome (GO:0072663)3.12080033
76protein localization to peroxisome (GO:0072662)3.12080033
77regulation of gamma-delta T cell activation (GO:0046643)3.11292493
78regulation of chemokine secretion (GO:0090196)3.09111734
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06830889
80endothelial cell proliferation (GO:0001935)3.06572942
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01003010
82negative regulation of T-helper cell differentiation (GO:0045623)2.97566267
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97566267
84negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.94031412
85behavioral response to nicotine (GO:0035095)2.92422089
86axonemal dynein complex assembly (GO:0070286)2.91278614
87regulation of cytokine production involved in inflammatory response (GO:1900015)2.89032256
88sister chromatid cohesion (GO:0007062)2.88919155
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.81783650
90anterograde synaptic vesicle transport (GO:0048490)2.79496711
91protein targeting to membrane (GO:0006612)2.78921989
92peroxisomal transport (GO:0043574)2.77347810
93regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.71296100
94positive regulation of interleukin-17 production (GO:0032740)2.68686493
95bile acid biosynthetic process (GO:0006699)2.68622028
96negative regulation of B cell apoptotic process (GO:0002903)2.68526418
97motile cilium assembly (GO:0044458)2.67442841
98regulation of T-helper 1 cell differentiation (GO:0045625)2.63695568
99ribosomal small subunit biogenesis (GO:0042274)13.8032007
100ncRNA 3-end processing (GO:0043628)12.7198710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43890615
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65112003
3AR_21572438_ChIP-Seq_LNCaP_Human3.39199040
4RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.25941610
5EGR1_19032775_ChIP-ChIP_M12_Human2.11308543
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.03384581
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01957444
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00662725
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat10.4660762
10JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97201049
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92492376
12SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88723601
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88350880
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87488239
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81964679
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.80408984
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67926591
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62328322
19ERA_21632823_ChIP-Seq_H3396_Human1.57804336
20FUS_26573619_Chip-Seq_HEK293_Human1.57515782
21NANOG_20526341_ChIP-Seq_ESCs_Human1.55396759
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55366006
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55366006
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.53355204
25ZNF274_21170338_ChIP-Seq_K562_Hela1.53073923
26TAF15_26573619_Chip-Seq_HEK293_Human1.51943206
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48271997
28PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.47332725
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42932603
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40816710
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39553806
32BCL6_27268052_Chip-Seq_Bcells_Human1.35889708
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35712692
34SMRT_27268052_Chip-Seq_Bcells_Human1.35131016
35CTCF_27219007_Chip-Seq_Bcells_Human1.33163223
36RNF2_27304074_Chip-Seq_NSC_Mouse1.31712879
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29637500
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.29007202
39TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28970309
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28815175
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28815175
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27545345
43BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24936914
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24872387
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22208231
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22182292
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21972833
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.19047690
49SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17939374
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.17598711
51FOXH1_21741376_ChIP-Seq_EPCs_Human1.15147271
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14959525
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14956862
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14309684
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13570664
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.13559364
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11236646
58NANOG_19829295_ChIP-Seq_ESCs_Human1.07953112
59SOX2_19829295_ChIP-Seq_ESCs_Human1.07953112
60JUN_21703547_ChIP-Seq_K562_Human1.07288574
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05910813
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.05767274
63P300_19829295_ChIP-Seq_ESCs_Human1.05409908
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.05245025
65EWS_26573619_Chip-Seq_HEK293_Human1.04934212
66TP53_22573176_ChIP-Seq_HFKS_Human1.03978148
67VDR_22108803_ChIP-Seq_LS180_Human1.03215873
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01611811
69RUNX_20019798_ChIP-Seq_JUKART_Human1.00435840
70NCOR_22424771_ChIP-Seq_293T_Human0.98709310
71BCAT_22108803_ChIP-Seq_LS180_Human0.98561060
72TAF2_19829295_ChIP-Seq_ESCs_Human0.97839819
73P300_27268052_Chip-Seq_Bcells_Human0.97639216
74TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97450646
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.96751539
76REST_21632747_ChIP-Seq_MESCs_Mouse0.95933723
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.95542645
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95542645
79E2F1_20622854_ChIP-Seq_HELA_Human0.95206844
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95079472
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94829418
82CBP_20019798_ChIP-Seq_JUKART_Human0.94749984
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94749984
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.93232966
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92897752
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92726138
87CTCF_20526341_ChIP-Seq_ESCs_Human0.91108019
88SPI1_20517297_ChIP-Seq_HL60_Human0.91096321
89BCOR_27268052_Chip-Seq_Bcells_Human0.90494067
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89896610
91SA1_27219007_Chip-Seq_Bcells_Human0.88468716
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88377224
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87774843
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86227690
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.85475875
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.85384820
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85243598
98TP53_20018659_ChIP-ChIP_R1E_Mouse0.84827130
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82777466
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82623621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis8.82208866
2MP0003879_abnormal_hair_cell5.48144448
3MP0001873_stomach_inflammation5.15379023
4MP0006082_CNS_inflammation4.96107653
5MP0009379_abnormal_foot_pigmentation3.54254949
6MP0001727_abnormal_embryo_implantation3.37792127
7MP0003121_genomic_imprinting3.15961732
8MP0009780_abnormal_chondrocyte_physiolo2.90385740
9MP0002933_joint_inflammation2.60693405
10MP0006292_abnormal_olfactory_placode2.42703097
11MP0003646_muscle_fatigue2.15164659
12MP0001663_abnormal_digestive_system1.95733605
13MP0005174_abnormal_tail_pigmentation1.95531214
14MP0003878_abnormal_ear_physiology1.86426804
15MP0005377_hearing/vestibular/ear_phenot1.86426804
16MP0001348_abnormal_lacrimal_gland1.77972038
17MP0001851_eye_inflammation1.70737163
18MP0004145_abnormal_muscle_electrophysio1.57241722
19MP0001853_heart_inflammation1.55292172
20MP0008875_abnormal_xenobiotic_pharmacok1.42192228
21MP0005381_digestive/alimentary_phenotyp1.36408687
22MP0005551_abnormal_eye_electrophysiolog1.35219341
23MP0002163_abnormal_gland_morphology1.34409088
24MP0000015_abnormal_ear_pigmentation1.34397511
25MP0005397_hematopoietic_system_phenotyp1.33642176
26MP0001545_abnormal_hematopoietic_system1.33642176
27MP0005671_abnormal_response_to1.32180452
28MP0004947_skin_inflammation1.29706792
29MP0003195_calcinosis1.20532233
30MP0001968_abnormal_touch/_nociception1.19862785
31MP0005075_abnormal_melanosome_morpholog1.19424411
32MP0008877_abnormal_DNA_methylation1.13639913
33MP0002638_abnormal_pupillary_reflex1.13473650
34MP0002405_respiratory_system_inflammati1.11472431
35MP0001800_abnormal_humoral_immune1.11297525
36MP0004084_abnormal_cardiac_muscle1.09281913
37MP0009785_altered_susceptibility_to1.04848856
38MP0009765_abnormal_xenobiotic_induced1.04796859
39MP0000026_abnormal_inner_ear1.04767060
40MP0001905_abnormal_dopamine_level1.01502508
41MP0002095_abnormal_skin_pigmentation1.00994480
42MP0001915_intracranial_hemorrhage1.00463133
43MP0005379_endocrine/exocrine_gland_phen0.98796462
44MP0002837_dystrophic_cardiac_calcinosis0.97177258
45MP0009333_abnormal_splenocyte_physiolog0.94507135
46MP0006276_abnormal_autonomic_nervous0.94080397
47MP0005423_abnormal_somatic_nervous0.93668060
48MP0002876_abnormal_thyroid_physiology0.90478600
49MP0001533_abnormal_skeleton_physiology0.89730508
50MP0000566_synostosis0.89607077
51MP0005197_abnormal_uvea_morphology0.89012785
52MP0005195_abnormal_posterior_eye0.88625252
53MP0004858_abnormal_nervous_system0.87349739
54MP0003693_abnormal_embryo_hatching0.85152738
55MP0004742_abnormal_vestibular_system0.85139339
56MP0008872_abnormal_physiological_respon0.83320268
57MP0002736_abnormal_nociception_after0.82125013
58MP0005645_abnormal_hypothalamus_physiol0.81445082
59MP0005670_abnormal_white_adipose0.80352314
60MP0005410_abnormal_fertilization0.79887489
61MP0001963_abnormal_hearing_physiology0.75893535
62MP0003938_abnormal_ear_development0.74494311
63MP0002822_catalepsy0.74286239
64MP0009250_abnormal_appendicular_skeleto0.73688926
65MP0002116_abnormal_craniofacial_bone0.71004191
66MP0002108_abnormal_muscle_morphology0.70592234
67MP0002735_abnormal_chemical_nociception0.68695388
68MP0001790_abnormal_immune_system0.66403487
69MP0005387_immune_system_phenotype0.66403487
70MP0002229_neurodegeneration0.62597957
71MP0000049_abnormal_middle_ear0.62593639
72MP0002138_abnormal_hepatobiliary_system0.62304453
73MP0002572_abnormal_emotion/affect_behav0.62174009
74MP0001986_abnormal_taste_sensitivity0.60565807
75MP0003183_abnormal_peptide_metabolism0.59980422
76MP0001970_abnormal_pain_threshold0.59632763
77MP0005646_abnormal_pituitary_gland0.59256918
78MP0000534_abnormal_ureter_morphology0.57601050
79MP0002272_abnormal_nervous_system0.57303101
80MP0002452_abnormal_antigen_presenting0.57021404
81MP0004036_abnormal_muscle_relaxation0.56684260
82MP0003763_abnormal_thymus_physiology0.56085969
83MP0002752_abnormal_somatic_nervous0.55480446
84MP0001835_abnormal_antigen_presentation0.55364976
85MP0008789_abnormal_olfactory_epithelium0.54655005
86MP0002998_abnormal_bone_remodeling0.54555792
87MP0009764_decreased_sensitivity_to0.53953166
88MP0003866_abnormal_defecation0.53692012
89MP0002420_abnormal_adaptive_immunity0.52278085
90MP0005369_muscle_phenotype0.52075447
91MP0002419_abnormal_innate_immunity0.51692446
92MP0002115_abnormal_skeleton_extremities0.51684421
93MP0005084_abnormal_gallbladder_morpholo0.50823476
94MP0002723_abnormal_immune_serum0.50688318
95MP0000689_abnormal_spleen_morphology0.50639318
96MP0002557_abnormal_social/conspecific_i0.50326195
97MP0000604_amyloidosis0.49231505
98MP0004130_abnormal_muscle_cell0.48888667
99MP0010030_abnormal_orbit_morphology0.48572872
100MP0002113_abnormal_skeleton_development0.47129291

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)8.64852164
2Striae distensae (HP:0001065)8.49042688
3Metaphyseal cupping (HP:0003021)8.48934683
4Abnormality of macular pigmentation (HP:0008002)8.37913874
5Constricted visual fields (HP:0001133)8.11864327
6Volvulus (HP:0002580)7.66474217
7Cupped ribs (HP:0000887)7.15244957
8Cone-rod dystrophy (HP:0000548)6.84151645
9Attenuation of retinal blood vessels (HP:0007843)6.33664920
10Toxemia of pregnancy (HP:0100603)6.23046981
11Large earlobe (HP:0009748)5.63911285
12Decreased electroretinogram (ERG) amplitude (HP:0000654)5.18225855
13Absent rod-and cone-mediated responses on ERG (HP:0007688)5.00603953
14Oligodontia (HP:0000677)4.13633539
15Decreased muscle mass (HP:0003199)4.09972025
16Severe visual impairment (HP:0001141)4.03351519
17Broad nasal tip (HP:0000455)3.98184002
18Tibial bowing (HP:0002982)3.92325538
19Small hand (HP:0200055)3.64654786
20Abnormal rod and cone electroretinograms (HP:0008323)3.60936640
21Lack of skin elasticity (HP:0100679)3.58721193
22Ovoid vertebral bodies (HP:0003300)3.44497466
23Femoral bowing (HP:0002980)3.44124864
24Abnormality of lateral ventricle (HP:0030047)3.20154669
25Hypoplastic ilia (HP:0000946)2.97707603
26Coxa vara (HP:0002812)2.89838810
27Aplasia/Hypoplasia of the earlobes (HP:0009906)2.83563438
28Limited elbow extension (HP:0001377)2.79078225
29Optic disc pallor (HP:0000543)2.78075375
30Recurrent otitis media (HP:0000403)2.77184931
31Abnormal ciliary motility (HP:0012262)2.71008635
32Absent/shortened dynein arms (HP:0200106)2.68561045
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.68561045
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66917335
35Progressive visual loss (HP:0000529)2.64441473
36Pendular nystagmus (HP:0012043)2.63564684
37Hyperthyroidism (HP:0000836)2.59234818
38Blepharitis (HP:0000498)2.55994093
39Brushfield spots (HP:0001088)2.52540488
40Rhizomelia (HP:0008905)2.44858255
41Prominent supraorbital ridges (HP:0000336)2.42811110
42Decreased central vision (HP:0007663)2.38751137
43Abnormal respiratory motile cilium physiology (HP:0012261)2.35358227
44Proximal placement of thumb (HP:0009623)2.31126331
45Long eyelashes (HP:0000527)2.30141297
46Truncal obesity (HP:0001956)2.25927324
47Hematochezia (HP:0002573)2.23147056
48Retinitis pigmentosa (HP:0000510)2.20500796
49Concave nail (HP:0001598)2.18343304
50Aplasia/Hypoplasia of the nipples (HP:0006709)2.15483705
51Prenatal maternal abnormality (HP:0002686)2.11991197
52Postnatal growth retardation (HP:0008897)2.04457874
53Abnormality of fatty-acid metabolism (HP:0004359)2.00923683
54Hypoplastic ischia (HP:0003175)2.00341433
55Acanthocytosis (HP:0001927)1.98236488
56Deviation of the thumb (HP:0009603)1.97334906
57Hyperglycinemia (HP:0002154)1.96306944
58Increased nuchal translucency (HP:0010880)1.95242369
59Abnormal respiratory epithelium morphology (HP:0012253)1.94629756
60Abnormal respiratory motile cilium morphology (HP:0005938)1.94629756
61Increased corneal curvature (HP:0100692)1.92710055
62Keratoconus (HP:0000563)1.92710055
63Congenital sensorineural hearing impairment (HP:0008527)1.92701002
64Bony spicule pigmentary retinopathy (HP:0007737)1.91776506
65Photophobia (HP:0000613)1.91234931
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89578878
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86536293
68Delayed puberty (HP:0000823)1.84549076
69Childhood onset (HP:0011463)1.83748309
70Dyskinesia (HP:0100660)1.83445855
71Asplenia (HP:0001746)1.80571281
72Widely spaced teeth (HP:0000687)1.79973301
73Abnormality of the labia minora (HP:0012880)1.79856157
74Freckling (HP:0001480)1.78493615
75Hypoplastic labia majora (HP:0000059)1.78488158
76Abnormality of the pubic bones (HP:0003172)1.72762105
77Reticulocytopenia (HP:0001896)1.72396858
78Preauricular skin tag (HP:0000384)1.69089568
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.68870732
80Recurrent sinusitis (HP:0011108)1.68682020
81Abnormality of the ischium (HP:0003174)1.67450409
82Abnormality of the labia majora (HP:0012881)1.64714582
83Congenital, generalized hypertrichosis (HP:0004540)1.62605872
84Skin tags (HP:0010609)1.54261247
85Multicystic kidney dysplasia (HP:0000003)1.52816361
86Lymphedema (HP:0001004)1.50441455
87Thickened nuchal skin fold (HP:0000474)1.49825946
88Obsessive-compulsive behavior (HP:0000722)1.47749806
89Disinhibition (HP:0000734)1.47004142
90IgM deficiency (HP:0002850)1.45833934
91Low posterior hairline (HP:0002162)1.44702826
92Decreased testicular size (HP:0008734)1.43123013
93Bronchiectasis (HP:0002110)1.40619254
94Epiphyseal stippling (HP:0010655)1.40507634
95Albinism (HP:0001022)1.39835657
96Rhinitis (HP:0012384)1.39139496
97Radioulnar synostosis (HP:0002974)1.38350731
98Chronic hepatic failure (HP:0100626)1.37609392
99Akinesia (HP:0002304)1.37303416
100Hemiplegia (HP:0002301)1.36053719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT9.03766679
2FES4.97537704
3TEC4.63273530
4TYRO33.40771978
5MAP4K12.78608810
6SIK22.47011056
7CDK192.40550015
8CSK2.23142131
9TESK22.16556886
10IKBKB2.07923961
11SYK1.92566322
12BCKDK1.88842814
13NME21.68333024
14WNK41.55053003
15TIE11.52986883
16TRIM281.49086500
17GRK11.41904274
18NEK21.35200264
19RET1.34747994
20ADRBK21.33145096
21CDK31.26214025
22MAP4K21.25614679
23TESK11.12960096
24INSRR1.11141167
25CSF1R1.05682269
26WNK31.05478341
27IKBKE1.00157856
28MUSK0.98324089
29FRK0.96278781
30RPS6KB20.92883419
31INSR0.91655182
32RIPK40.91423840
33MAP3K40.89106790
34EGFR0.88798786
35BTK0.85429414
36ADRBK10.85370407
37DDR20.83589226
38CASK0.80225098
39LRRK20.78766959
40MAPK150.78583497
41PRKCG0.78452054
42SRC0.75352894
43PRKACA0.75050755
44ABL20.74621859
45PLK40.74346300
46LCK0.72418013
47EPHB20.72280406
48FGR0.69451342
49OBSCN0.68025388
50STK390.63564208
51CSNK1D0.60821266
52LIMK10.60437905
53DYRK20.60223306
54PIK3CG0.58263496
55MAPK100.57746219
56TLK10.56388934
57OXSR10.54119727
58PRKACG0.54098159
59PRKCQ0.52166867
60KDR0.52147114
61NTRK20.51856823
62MAP3K110.51494029
63LYN0.50581850
64PRKCH0.48776052
65GRK70.47183920
66STK160.46782373
67PRKCB0.46578991
68PRKCA0.45944718
69PKN10.44988516
70PHKG10.44364676
71PHKG20.44364676
72TXK0.43739415
73ITK0.42387789
74CAMK2A0.41720472
75PDGFRB0.39117357
76PINK10.38847164
77RPS6KA60.38399676
78CSNK1E0.36722170
79ABL10.36384512
80BMPR20.35252559
81GRK60.33581669
82RPS6KA40.32878378
83ZAK0.32327884
84FYN0.31328261
85TBK10.31262869
86PRKACB0.29798671
87AURKA0.27838195
88PDK20.27187997
89STK380.26152753
90RPS6KC10.25959757
91RPS6KL10.25959757
92PIK3CA0.25718109
93PRKCZ0.25625593
94MAP2K70.25456511
95PRKCE0.25319819
96CAMK10.23594188
97RPS6KA30.23482494
98MAPK130.23355475
99MAP2K60.22017203
100PLK10.21131652

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.33001587
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.24534255
3Phototransduction_Homo sapiens_hsa047443.14308737
4Oxidative phosphorylation_Homo sapiens_hsa001903.08916784
5Graft-versus-host disease_Homo sapiens_hsa053322.84791286
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63046968
7Histidine metabolism_Homo sapiens_hsa003402.48211166
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34765795
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.07773087
10Olfactory transduction_Homo sapiens_hsa047402.07363296
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97354240
12Allograft rejection_Homo sapiens_hsa053301.89713750
13Autoimmune thyroid disease_Homo sapiens_hsa053201.86938996
14Tryptophan metabolism_Homo sapiens_hsa003801.77762998
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77734725
16Parkinsons disease_Homo sapiens_hsa050121.77602675
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72003869
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64726790
19Nicotine addiction_Homo sapiens_hsa050331.63102795
20Hematopoietic cell lineage_Homo sapiens_hsa046401.57203069
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56942394
22Asthma_Homo sapiens_hsa053101.56645756
23Type I diabetes mellitus_Homo sapiens_hsa049401.55378309
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.54451395
25Arachidonic acid metabolism_Homo sapiens_hsa005901.47137983
26Alzheimers disease_Homo sapiens_hsa050101.45086304
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.35196386
28Huntingtons disease_Homo sapiens_hsa050161.33628554
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32448299
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.29697291
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28950948
32beta-Alanine metabolism_Homo sapiens_hsa004101.24651575
33Taste transduction_Homo sapiens_hsa047421.14926636
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14706843
35Cardiac muscle contraction_Homo sapiens_hsa042601.14443248
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13634846
37Staphylococcus aureus infection_Homo sapiens_hsa051501.08805009
38Notch signaling pathway_Homo sapiens_hsa043301.02493504
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96520897
40Arginine and proline metabolism_Homo sapiens_hsa003300.95597405
41Linoleic acid metabolism_Homo sapiens_hsa005910.93306419
42Rheumatoid arthritis_Homo sapiens_hsa053230.91186453
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90630567
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87147580
45Primary immunodeficiency_Homo sapiens_hsa053400.84725276
46Alcoholism_Homo sapiens_hsa050340.82697246
47Tyrosine metabolism_Homo sapiens_hsa003500.80472909
48Caffeine metabolism_Homo sapiens_hsa002320.80363097
49T cell receptor signaling pathway_Homo sapiens_hsa046600.79335374
50FoxO signaling pathway_Homo sapiens_hsa040680.77475549
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76784242
52Fatty acid biosynthesis_Homo sapiens_hsa000610.75218759
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74969727
54Long-term potentiation_Homo sapiens_hsa047200.73397119
55Retinol metabolism_Homo sapiens_hsa008300.73127261
56Antigen processing and presentation_Homo sapiens_hsa046120.72406429
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.71856317
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.69172331
59Fatty acid degradation_Homo sapiens_hsa000710.68210355
60Serotonergic synapse_Homo sapiens_hsa047260.68191051
61Chemical carcinogenesis_Homo sapiens_hsa052040.64351124
62Peroxisome_Homo sapiens_hsa041460.60427218
63Calcium signaling pathway_Homo sapiens_hsa040200.59245720
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58537740
65Protein digestion and absorption_Homo sapiens_hsa049740.57587229
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53750729
67Malaria_Homo sapiens_hsa051440.53057027
68Viral myocarditis_Homo sapiens_hsa054160.52353483
69Starch and sucrose metabolism_Homo sapiens_hsa005000.50141334
70Glycerolipid metabolism_Homo sapiens_hsa005610.49241004
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.46390264
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46009244
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45576005
74Basal transcription factors_Homo sapiens_hsa030220.44750792
75RNA degradation_Homo sapiens_hsa030180.43369227
76Pyruvate metabolism_Homo sapiens_hsa006200.42533712
77Basal cell carcinoma_Homo sapiens_hsa052170.41654028
78ABC transporters_Homo sapiens_hsa020100.41626502
79Sulfur metabolism_Homo sapiens_hsa009200.39746414
80Systemic lupus erythematosus_Homo sapiens_hsa053220.39546464
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37660555
82Pertussis_Homo sapiens_hsa051330.35851759
83Nitrogen metabolism_Homo sapiens_hsa009100.35766326
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35696630
85Morphine addiction_Homo sapiens_hsa050320.34475031
86Choline metabolism in cancer_Homo sapiens_hsa052310.33896163
87Amphetamine addiction_Homo sapiens_hsa050310.33716496
88Cocaine addiction_Homo sapiens_hsa050300.33228134
89Insulin secretion_Homo sapiens_hsa049110.33221416
90Salivary secretion_Homo sapiens_hsa049700.32739631
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32328079
92Measles_Homo sapiens_hsa051620.31982655
93Fat digestion and absorption_Homo sapiens_hsa049750.30842839
94cAMP signaling pathway_Homo sapiens_hsa040240.30254223
95Dorso-ventral axis formation_Homo sapiens_hsa043200.29280031
96Melanoma_Homo sapiens_hsa052180.28014300
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.27131745
98Bladder cancer_Homo sapiens_hsa052190.26636840
99Metabolic pathways_Homo sapiens_hsa011000.26524632
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.25007000

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