TPT1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)7.90253229
2ribosomal small subunit biogenesis (GO:0042274)6.86932261
3viral transcription (GO:0019083)6.50613563
4translational termination (GO:0006415)6.20500986
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.02094812
6ATP synthesis coupled proton transport (GO:0015986)6.02094812
7protein neddylation (GO:0045116)5.90320648
8GDP-mannose metabolic process (GO:0019673)5.66002192
9translational elongation (GO:0006414)5.46636211
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.22279618
11protein targeting to ER (GO:0045047)5.15689834
12cotranslational protein targeting to membrane (GO:0006613)5.14538860
13ribosomal small subunit assembly (GO:0000028)5.08573880
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.95541411
15protein localization to endoplasmic reticulum (GO:0070972)4.89950940
16viral life cycle (GO:0019058)4.82898872
17cellular protein complex disassembly (GO:0043624)4.70954938
18nucleoside transmembrane transport (GO:1901642)4.66937096
19mannose metabolic process (GO:0006013)4.47513401
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31511021
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18607304
22translational initiation (GO:0006413)3.92623886
23nucleoside transport (GO:0015858)3.87204610
24thrombin receptor signaling pathway (GO:0070493)3.83990930
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.82766123
26ribosomal large subunit biogenesis (GO:0042273)3.76504293
27protein complex disassembly (GO:0043241)3.73584884
28DNA deamination (GO:0045006)3.72869916
29protein targeting to membrane (GO:0006612)3.66493538
30negative regulation of heart rate (GO:0010459)3.59985420
31interferon-gamma production (GO:0032609)3.58220313
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49595217
33maturation of SSU-rRNA (GO:0030490)3.46344033
34macromolecular complex disassembly (GO:0032984)3.45001388
35ATP biosynthetic process (GO:0006754)3.44258327
36translation (GO:0006412)3.35969414
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.34115037
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32373969
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31241182
40pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29787817
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27396652
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27396652
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26693410
44regulation of immunoglobulin secretion (GO:0051023)3.26190856
45reproduction (GO:0000003)3.21244860
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.21170771
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18923207
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.18923207
49NADH dehydrogenase complex assembly (GO:0010257)3.18923207
50respiratory electron transport chain (GO:0022904)3.17057623
51electron transport chain (GO:0022900)3.16940610
52regulation of mitochondrial membrane potential (GO:0051881)3.16866121
53protein complex biogenesis (GO:0070271)3.16255217
54regulation of regulatory T cell differentiation (GO:0045589)3.09804103
55cellular component biogenesis (GO:0044085)3.05609737
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04101853
57pyrimidine nucleotide catabolic process (GO:0006244)3.03724366
58modified amino acid transport (GO:0072337)3.02653558
59prenylation (GO:0097354)3.02231818
60protein prenylation (GO:0018342)3.02231818
61GTP biosynthetic process (GO:0006183)3.01994622
62antibacterial humoral response (GO:0019731)3.00933810
63peroxisome fission (GO:0016559)2.99490968
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99088875
65regulation of isotype switching to IgG isotypes (GO:0048302)2.97613211
66nuclear-transcribed mRNA catabolic process (GO:0000956)2.95954909
67neutrophil activation involved in immune response (GO:0002283)2.95082604
68cardiolipin metabolic process (GO:0032048)2.91577493
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.81896118
70ribonucleoprotein complex biogenesis (GO:0022613)2.80070211
71mitochondrial respiratory chain complex assembly (GO:0033108)2.79957593
72ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77938245
73negative regulation of calcium ion transport into cytosol (GO:0010523)2.77080965
74negative regulation of appetite (GO:0032099)2.75670706
75negative regulation of response to food (GO:0032096)2.75670706
76innate immune response in mucosa (GO:0002227)2.75382060
77positive regulation of isotype switching (GO:0045830)2.73914139
78mRNA catabolic process (GO:0006402)2.71818519
79regulation of podosome assembly (GO:0071801)2.71796400
80amine catabolic process (GO:0009310)2.71730395
81cellular biogenic amine catabolic process (GO:0042402)2.71730395
82antimicrobial humoral response (GO:0019730)2.71561616
83neuronal action potential propagation (GO:0019227)2.69733437
84behavioral response to nicotine (GO:0035095)2.69432503
85positive regulation of DNA recombination (GO:0045911)2.68764389
86guanosine-containing compound biosynthetic process (GO:1901070)2.68131900
87cytidine metabolic process (GO:0046087)2.67138294
88cytidine catabolic process (GO:0006216)2.67138294
89cytidine deamination (GO:0009972)2.67138294
90positive regulation of fatty acid transport (GO:2000193)2.66925680
91positive regulation of icosanoid secretion (GO:0032305)2.65334033
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63721908
93signal peptide processing (GO:0006465)2.63238897
94establishment of protein localization to membrane (GO:0090150)2.62859459
95UTP biosynthetic process (GO:0006228)2.55570123
96phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.54484621
97positive regulation of respiratory burst (GO:0060267)2.53326996
98positive regulation of activated T cell proliferation (GO:0042104)2.53298963
99positive regulation of mast cell activation (GO:0033005)2.52503353
100platelet dense granule organization (GO:0060155)2.51722409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.38309660
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.35442371
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.73244287
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63872230
5EZH2_22144423_ChIP-Seq_EOC_Human3.22450651
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94364777
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.61312612
8VDR_22108803_ChIP-Seq_LS180_Human2.56109883
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.52333440
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.33868726
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.29923507
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27619829
13PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.03005238
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94001489
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.67372757
16IRF1_19129219_ChIP-ChIP_H3396_Human1.63471256
17NANOG_20526341_ChIP-Seq_ESCs_Human1.54890560
18GATA3_21878914_ChIP-Seq_MCF-7_Human1.53435567
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49881449
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49422412
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47330742
22EWS_26573619_Chip-Seq_HEK293_Human1.41182035
23RUNX_20019798_ChIP-Seq_JUKART_Human1.40636912
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40313371
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37765816
26GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35123125
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33295468
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31703892
29STAT1_20625510_ChIP-Seq_HELA_Human1.29017002
30GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.24690548
31PHF8_20622853_ChIP-Seq_HELA_Human1.23366989
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.23244531
33PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20296889
34RBPJ_21746931_ChIP-Seq_IB4_Human1.20193681
35VDR_23849224_ChIP-Seq_CD4+_Human1.20145925
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19815408
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.19815408
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19336114
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18862922
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18403203
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17640681
42GATA1_22025678_ChIP-Seq_K562_Human1.15342394
43TAF2_19829295_ChIP-Seq_ESCs_Human1.14683867
44ZNF274_21170338_ChIP-Seq_K562_Hela1.13789996
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13342798
46TP53_22573176_ChIP-Seq_HFKS_Human1.13339759
47BCL6_27268052_Chip-Seq_Bcells_Human1.13122381
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.12923997
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12628453
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12559525
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12429107
52HTT_18923047_ChIP-ChIP_STHdh_Human1.11293231
53FOXH1_21741376_ChIP-Seq_ESCs_Human1.10096758
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10037090
55CTCF_20526341_ChIP-Seq_ESCs_Human1.09239651
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07732992
57NANOG_19829295_ChIP-Seq_ESCs_Human1.07586065
58SOX2_19829295_ChIP-Seq_ESCs_Human1.07586065
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.07103723
60MYC_19829295_ChIP-Seq_ESCs_Human1.06413698
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.05311626
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.04622362
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04609874
64RNF2_27304074_Chip-Seq_NSC_Mouse1.04152217
65SA1_27219007_Chip-Seq_Bcells_Human0.99852642
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99830908
67SOX2_21211035_ChIP-Seq_LN229_Human0.99185778
68FOXP3_21729870_ChIP-Seq_TREG_Human0.98770333
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98103411
70ETV1_20927104_ChIP-Seq_GIST48_Human0.97615148
71ERG_20517297_ChIP-Seq_VCAP_Human0.97601829
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97599182
73AR_20517297_ChIP-Seq_VCAP_Human0.97512560
74NFYA_21822215_ChIP-Seq_K562_Human0.97273620
75P53_21459846_ChIP-Seq_SAOS-2_Human0.95807694
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95519139
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95447479
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95176643
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95175372
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94373529
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93992478
82TAF15_26573619_Chip-Seq_HEK293_Human0.93147716
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92950542
84NFYB_21822215_ChIP-Seq_K562_Human0.91742987
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91681696
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91657260
87BP1_19119308_ChIP-ChIP_Hs578T_Human0.91229475
88E2F1_20622854_ChIP-Seq_HELA_Human0.90051189
89GATA3_26560356_Chip-Seq_TH2_Human0.89149320
90IRF8_22096565_ChIP-ChIP_GC-B_Human0.89021426
91MYC_18940864_ChIP-ChIP_HL60_Human0.88625759
92ERA_21632823_ChIP-Seq_H3396_Human0.88515073
93NCOR_22424771_ChIP-Seq_293T_Human0.88190596
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87935716
95IGF1R_20145208_ChIP-Seq_DFB_Human0.87595091
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87046185
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86452345
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.86245116
99SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85709816
100P300_27268052_Chip-Seq_Bcells_Human0.82966959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.34645465
2MP0005464_abnormal_platelet_physiology4.23455129
3MP0002638_abnormal_pupillary_reflex3.60029253
4MP0005671_abnormal_response_to3.25764034
5MP0001835_abnormal_antigen_presentation2.93270563
6MP0003646_muscle_fatigue2.81912323
7MP0008872_abnormal_physiological_respon2.38948126
8MP0003724_increased_susceptibility_to2.02654191
9MP0001873_stomach_inflammation2.00819931
10MP0002148_abnormal_hypersensitivity_rea1.95466870
11MP0010155_abnormal_intestine_physiology1.93567422
12MP0009333_abnormal_splenocyte_physiolog1.91043673
13MP0005387_immune_system_phenotype1.90652761
14MP0001790_abnormal_immune_system1.90652761
15MP0008875_abnormal_xenobiotic_pharmacok1.90294506
16MP0006292_abnormal_olfactory_placode1.89823309
17MP0008004_abnormal_stomach_pH1.83107794
18MP0001663_abnormal_digestive_system1.78971460
19MP0004147_increased_porphyrin_level1.74669068
20MP0000465_gastrointestinal_hemorrhage1.74140512
21MP0004142_abnormal_muscle_tone1.66877262
22MP0001545_abnormal_hematopoietic_system1.63993769
23MP0005397_hematopoietic_system_phenotyp1.63993769
24MP0001188_hyperpigmentation1.63689100
25MP0008775_abnormal_heart_ventricle1.57838894
26MP0000343_altered_response_to1.55569220
27MP0005360_urolithiasis1.51388167
28MP0005174_abnormal_tail_pigmentation1.50674220
29MP0004885_abnormal_endolymph1.49017552
30MP0002736_abnormal_nociception_after1.46047725
31MP0000230_abnormal_systemic_arterial1.45406720
32MP0005000_abnormal_immune_tolerance1.43667653
33MP0005646_abnormal_pituitary_gland1.42464229
34MP0001800_abnormal_humoral_immune1.39610663
35MP0004043_abnormal_pH_regulation1.38569741
36MP0003186_abnormal_redox_activity1.38387768
37MP0005670_abnormal_white_adipose1.36783735
38MP0001968_abnormal_touch/_nociception1.35522448
39MP0002876_abnormal_thyroid_physiology1.33545593
40MP0000685_abnormal_immune_system1.31214519
41MP0004145_abnormal_muscle_electrophysio1.25926466
42MP0005645_abnormal_hypothalamus_physiol1.22791553
43MP0009785_altered_susceptibility_to1.21423504
44MP0004858_abnormal_nervous_system1.20991811
45MP0005389_reproductive_system_phenotype1.18430162
46MP0005381_digestive/alimentary_phenotyp1.17332915
47MP0008877_abnormal_DNA_methylation1.15801946
48MP0005084_abnormal_gallbladder_morpholo1.15451904
49MP0005085_abnormal_gallbladder_physiolo1.15322654
50MP0003879_abnormal_hair_cell1.13179350
51MP0006072_abnormal_retinal_apoptosis1.12721915
52MP0009764_decreased_sensitivity_to1.12596003
53MP0001905_abnormal_dopamine_level1.12075244
54MP0001664_abnormal_digestion1.11711056
55MP0009765_abnormal_xenobiotic_induced1.09333270
56MP0002160_abnormal_reproductive_system1.07701464
57MP0002723_abnormal_immune_serum1.06441671
58MP0003303_peritoneal_inflammation1.04562781
59MP0002095_abnormal_skin_pigmentation1.02872475
60MP0005410_abnormal_fertilization1.01327057
61MP0002234_abnormal_pharynx_morphology0.99649816
62MP0002837_dystrophic_cardiac_calcinosis0.99465527
63MP0002398_abnormal_bone_marrow0.98048953
64MP0000678_abnormal_parathyroid_gland0.97795950
65MP0001919_abnormal_reproductive_system0.95799690
66MP0006276_abnormal_autonomic_nervous0.95364808
67MP0003718_maternal_effect0.94445949
68MP0001765_abnormal_ion_homeostasis0.94040140
69MP0003436_decreased_susceptibility_to0.92548174
70MP0001529_abnormal_vocalization0.91826717
71MP0005025_abnormal_response_to0.91554215
72MP0002452_abnormal_antigen_presenting0.91146164
73MP0000490_abnormal_crypts_of0.88690290
74MP0002138_abnormal_hepatobiliary_system0.88565768
75MP0003638_abnormal_response/metabolism_0.88243658
76MP0001845_abnormal_inflammatory_respons0.87817088
77MP0001727_abnormal_embryo_implantation0.87612920
78MP0005551_abnormal_eye_electrophysiolog0.86846553
79MP0002420_abnormal_adaptive_immunity0.85698635
80MP0005636_abnormal_mineral_homeostasis0.85417350
81MP0000372_irregular_coat_pigmentation0.83869601
82MP0001485_abnormal_pinna_reflex0.83428514
83MP0001879_abnormal_lymphatic_vessel0.82386271
84MP0001819_abnormal_immune_cell0.81637261
85MP0004215_abnormal_myocardial_fiber0.80382903
86MP0002733_abnormal_thermal_nociception0.79088008
87MP0002429_abnormal_blood_cell0.78397114
88MP0001666_abnormal_nutrient_absorption0.78110597
89MP0010329_abnormal_lipoprotein_level0.77958649
90MP0003011_delayed_dark_adaptation0.75038488
91MP0001533_abnormal_skeleton_physiology0.73772583
92MP0004130_abnormal_muscle_cell0.73065305
93MP0000716_abnormal_immune_system0.72786484
94MP0001970_abnormal_pain_threshold0.72544021
95MP0003866_abnormal_defecation0.70875700
96MP0009250_abnormal_appendicular_skeleto0.70864640
97MP0009643_abnormal_urine_homeostasis0.70094822
98MP0005167_abnormal_blood-brain_barrier0.68958129
99MP0006036_abnormal_mitochondrial_physio0.68789646
100MP0004019_abnormal_vitamin_homeostasis0.68064046

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)6.65907166
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.70066032
3Decreased central vision (HP:0007663)4.44510127
4Global brain atrophy (HP:0002283)4.04157033
5Prolonged bleeding time (HP:0003010)3.99981610
6Petechiae (HP:0000967)3.82139674
7Poikilocytosis (HP:0004447)3.70068560
8Increased hepatocellular lipid droplets (HP:0006565)3.51595000
9Purpura (HP:0000979)3.51155578
10Menorrhagia (HP:0000132)3.46598421
11Renal Fanconi syndrome (HP:0001994)3.42846204
12Abnormal rod and cone electroretinograms (HP:0008323)3.41907392
13Stomatitis (HP:0010280)3.36994697
14Exertional dyspnea (HP:0002875)3.36831127
15Mitochondrial inheritance (HP:0001427)3.35519608
16Dyskinesia (HP:0100660)3.31057560
17Acute necrotizing encephalopathy (HP:0006965)3.29078540
18Lipid accumulation in hepatocytes (HP:0006561)3.18988537
19Abnormality of the phalanges of the 2nd finger (HP:0009541)3.13388224
20Increased CSF lactate (HP:0002490)3.10209091
21Hypobetalipoproteinemia (HP:0003563)3.05835681
22Increased mean platelet volume (HP:0011877)3.03752534
23Elevated erythrocyte sedimentation rate (HP:0003565)2.94809935
24Abnormal mitochondria in muscle tissue (HP:0008316)2.92955856
25Pallor (HP:0000980)2.92216638
26Increased intramyocellular lipid droplets (HP:0012240)2.91737643
27Abnormality of cells of the erythroid lineage (HP:0012130)2.91371693
283-Methylglutaconic aciduria (HP:0003535)2.87708540
29Macrocytic anemia (HP:0001972)2.86588687
30Acute encephalopathy (HP:0006846)2.86000810
31Abnormal platelet volume (HP:0011876)2.76702387
32Progressive macrocephaly (HP:0004481)2.73027411
33Glycosuria (HP:0003076)2.67120618
34Abnormality of urine glucose concentration (HP:0011016)2.67120618
35Epistaxis (HP:0000421)2.64064075
36Methylmalonic acidemia (HP:0002912)2.63272444
37Hyperglycinemia (HP:0002154)2.62311024
38Reticulocytopenia (HP:0001896)2.60467573
39Decreased muscle mass (HP:0003199)2.57679816
40Pendular nystagmus (HP:0012043)2.57669189
41Hepatocellular necrosis (HP:0001404)2.56217942
42Abnormality of alanine metabolism (HP:0010916)2.49070128
43Hyperalaninemia (HP:0003348)2.49070128
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49070128
45Abnormal hemoglobin (HP:0011902)2.48947652
46Hepatic necrosis (HP:0002605)2.48528716
47Patent foramen ovale (HP:0001655)2.46894892
48Paralysis (HP:0003470)2.45358625
49Increased muscle lipid content (HP:0009058)2.43899631
50Neurodegeneration (HP:0002180)2.43432697
51Congenital stationary night blindness (HP:0007642)2.43154867
52Hyperlipoproteinemia (HP:0010980)2.42895994
53Agitation (HP:0000713)2.40376275
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39504383
55Congenital sensorineural hearing impairment (HP:0008527)2.34901864
56Congenital, generalized hypertrichosis (HP:0004540)2.34272337
57Attenuation of retinal blood vessels (HP:0007843)2.33657050
58Acute hepatic failure (HP:0006554)2.26704243
59Nausea (HP:0002018)2.25941958
60Hyperphosphaturia (HP:0003109)2.25151974
61Delayed CNS myelination (HP:0002188)2.23760601
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.18235975
63Respiratory difficulties (HP:0002880)2.17579777
64Increased IgM level (HP:0003496)2.16371205
65Akinesia (HP:0002304)2.14804886
66Microretrognathia (HP:0000308)2.11412855
67Renal tubular dysfunction (HP:0000124)2.08919646
68Optic disc pallor (HP:0000543)2.08247576
69Dyschromatopsia (HP:0007641)2.07279375
70Abnormality of vitamin B metabolism (HP:0004340)2.06326996
71Abnormality of the basal ganglia (HP:0002134)2.06176685
72Abnormal ciliary motility (HP:0012262)2.05842376
73Abnormality of renal resorption (HP:0011038)2.04432818
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.02498424
75Stenosis of the external auditory canal (HP:0000402)2.00443840
76CNS demyelination (HP:0007305)1.97305985
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96774352
78Dysphonia (HP:0001618)1.95062389
79Methylmalonic aciduria (HP:0012120)1.94501444
80Brushfield spots (HP:0001088)1.93777045
81Type 2 muscle fiber atrophy (HP:0003554)1.92641720
82Constricted visual fields (HP:0001133)1.91623049
83Abnormality of magnesium homeostasis (HP:0004921)1.89339699
84Abnormality of the 2nd finger (HP:0004100)1.88934784
85IgG deficiency (HP:0004315)1.86181527
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85004959
87Clumsiness (HP:0002312)1.84834134
88Generalized aminoaciduria (HP:0002909)1.84142306
89Short femoral neck (HP:0100864)1.83382644
90Muscle fiber atrophy (HP:0100295)1.80475084
91Abolished electroretinogram (ERG) (HP:0000550)1.80440027
92Abnormal respiratory motile cilium physiology (HP:0012261)1.79158538
93Gingival bleeding (HP:0000225)1.78845846
94Cerebral edema (HP:0002181)1.78685517
95Abnormality of fatty-acid metabolism (HP:0004359)1.77692742
96Abnormal urine phosphate concentration (HP:0012599)1.76601599
97Metabolic alkalosis (HP:0200114)1.76495518
98Increased serum lactate (HP:0002151)1.76420175
99Abnormal number of erythroid precursors (HP:0012131)1.76251377
100Hypoproteinemia (HP:0003075)1.75680305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.20029636
2NME23.41441625
3MYLK2.64918942
4TXK2.55055136
5ADRBK22.34830217
6TEC2.24902158
7MAP4K22.21073401
8GRK12.17400374
9BMPR22.16737735
10CDK192.15292425
11RIPK42.13153091
12MAP2K62.01173711
13MAP4K11.81250752
14ILK1.81168822
15TAOK31.79109014
16MAP3K121.78914728
17PDK21.77168661
18WNK41.65059189
19GRK61.61663896
20BTK1.61385169
21TIE11.55805374
22ACVR1B1.53520223
23AKT31.49388157
24TLK11.48852075
25ERN11.41571185
26BMX1.38034485
27SYK1.37409323
28NUAK11.35448585
29CSF1R1.33385711
30PIK3CG1.32195297
31OXSR11.19476174
32IKBKB1.15770101
33DYRK21.13438876
34ADRBK11.10412308
35BMPR1B1.10388569
36KIT1.05056747
37DAPK31.04339040
38ITK1.03918639
39EIF2AK11.01733835
40PASK1.01651622
41TNIK1.01106989
42TGFBR11.00102677
43TRPM70.99582688
44LRRK20.98610245
45LCK0.95368249
46PINK10.95237027
47PTK2B0.93815466
48MATK0.93664390
49STK30.93385735
50INSRR0.92987119
51DAPK20.86551016
52GRK50.85168916
53STK390.84573141
54PRKCG0.83137550
55FES0.82221147
56PRKG20.81670635
57WNK30.79897403
58PKN10.78727871
59TNK20.74921181
60EPHB20.74901570
61AKT20.72753193
62ABL20.72750730
63OBSCN0.70029155
64ZAP700.69887362
65TRIM280.68792062
66PIM10.68361549
67PRKACA0.68234155
68RPS6KA60.67541869
69MAP3K110.65958348
70BRAF0.65845317
71LYN0.65679634
72FLT30.64735482
73FRK0.64509214
74PRKACG0.64111089
75PRKCQ0.62394633
76PRKCA0.61668985
77PRKCD0.59102708
78PAK10.57183296
79PNCK0.56851571
80HCK0.56060118
81RPS6KL10.55839000
82RPS6KC10.55839000
83CSK0.53946109
84CSNK2A10.53624057
85PIM20.53002453
86ZAK0.52940293
87CSNK2A20.52801849
88STK40.52128335
89PRKCH0.50860237
90SGK20.50835540
91CAMK2A0.48832473
92AURKA0.48457805
93PDK10.48431645
94BCKDK0.46986316
95PRKG10.46398377
96MKNK10.45959109
97MINK10.44157527
98SGK2230.43349972
99SGK4940.43349972
100PLK40.42548974

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.50252257
2Asthma_Homo sapiens_hsa053103.63907265
3Allograft rejection_Homo sapiens_hsa053303.28501175
4Oxidative phosphorylation_Homo sapiens_hsa001903.26844426
5Sulfur metabolism_Homo sapiens_hsa009202.88147931
6Autoimmune thyroid disease_Homo sapiens_hsa053202.81300226
7Parkinsons disease_Homo sapiens_hsa050122.74954381
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.66090863
9Graft-versus-host disease_Homo sapiens_hsa053322.52446199
10Linoleic acid metabolism_Homo sapiens_hsa005912.44281929
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38789236
12Type I diabetes mellitus_Homo sapiens_hsa049402.17922589
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16921299
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80142650
15Fat digestion and absorption_Homo sapiens_hsa049751.78663658
16Alzheimers disease_Homo sapiens_hsa050101.76636053
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75122119
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73574859
19Arachidonic acid metabolism_Homo sapiens_hsa005901.65319477
20Huntingtons disease_Homo sapiens_hsa050161.60033227
21Hematopoietic cell lineage_Homo sapiens_hsa046401.55220478
22Cardiac muscle contraction_Homo sapiens_hsa042601.52230540
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51241265
24Caffeine metabolism_Homo sapiens_hsa002321.44608580
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44433633
26Nitrogen metabolism_Homo sapiens_hsa009101.42700818
27RNA polymerase_Homo sapiens_hsa030201.26157987
28Platelet activation_Homo sapiens_hsa046111.25184102
29Regulation of autophagy_Homo sapiens_hsa041401.24276492
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18876207
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17730905
32Proteasome_Homo sapiens_hsa030501.16657992
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.16536152
34Primary immunodeficiency_Homo sapiens_hsa053401.13003272
35Rheumatoid arthritis_Homo sapiens_hsa053231.07101651
36Chemical carcinogenesis_Homo sapiens_hsa052040.96905647
37Steroid hormone biosynthesis_Homo sapiens_hsa001400.94746487
38Phototransduction_Homo sapiens_hsa047440.94114340
39Olfactory transduction_Homo sapiens_hsa047400.93097949
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91100092
41RNA degradation_Homo sapiens_hsa030180.90057104
42Ether lipid metabolism_Homo sapiens_hsa005650.89179052
43Glutathione metabolism_Homo sapiens_hsa004800.87338778
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86204370
45Protein export_Homo sapiens_hsa030600.84883533
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83759028
47Antigen processing and presentation_Homo sapiens_hsa046120.80964915
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78813504
49Retinol metabolism_Homo sapiens_hsa008300.77073990
50Arginine and proline metabolism_Homo sapiens_hsa003300.75932115
51Systemic lupus erythematosus_Homo sapiens_hsa053220.75828177
52Staphylococcus aureus infection_Homo sapiens_hsa051500.75714620
53T cell receptor signaling pathway_Homo sapiens_hsa046600.75474386
54Basal transcription factors_Homo sapiens_hsa030220.74655105
55Pyrimidine metabolism_Homo sapiens_hsa002400.70903544
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67995285
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67712792
58Fructose and mannose metabolism_Homo sapiens_hsa000510.67576840
59Collecting duct acid secretion_Homo sapiens_hsa049660.65892050
60Malaria_Homo sapiens_hsa051440.64823584
61Renin-angiotensin system_Homo sapiens_hsa046140.62366615
62Vitamin digestion and absorption_Homo sapiens_hsa049770.61542491
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60550901
64Purine metabolism_Homo sapiens_hsa002300.59120930
65Selenocompound metabolism_Homo sapiens_hsa004500.58877459
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57828626
67Serotonergic synapse_Homo sapiens_hsa047260.56312597
68Viral myocarditis_Homo sapiens_hsa054160.56067047
69Leishmaniasis_Homo sapiens_hsa051400.55430832
70Pancreatic secretion_Homo sapiens_hsa049720.54662474
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53697817
72Sulfur relay system_Homo sapiens_hsa041220.51907343
73Mineral absorption_Homo sapiens_hsa049780.50606843
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49816502
75Metabolic pathways_Homo sapiens_hsa011000.48685842
76Peroxisome_Homo sapiens_hsa041460.47866791
77Starch and sucrose metabolism_Homo sapiens_hsa005000.46296102
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46179593
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.44735542
80Glycerolipid metabolism_Homo sapiens_hsa005610.44529508
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.43913740
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38526420
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37994331
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.36951580
85Chemokine signaling pathway_Homo sapiens_hsa040620.36244856
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35456332
87African trypanosomiasis_Homo sapiens_hsa051430.35065442
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34261711
89Tyrosine metabolism_Homo sapiens_hsa003500.34251289
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.29986986
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29004608
92One carbon pool by folate_Homo sapiens_hsa006700.27937319
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26877886
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26664906
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26087014
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.25930055
97Morphine addiction_Homo sapiens_hsa050320.25662926
98Tryptophan metabolism_Homo sapiens_hsa003800.21504372
99Salivary secretion_Homo sapiens_hsa049700.20819486
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.16027230

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