TPT1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)6.51013632
2antibacterial humoral response (GO:0019731)6.15839460
3antimicrobial humoral response (GO:0019730)5.86287337
4GDP-mannose metabolic process (GO:0019673)5.84791299
5cellular response to zinc ion (GO:0071294)5.60270438
6regulation of cellular extravasation (GO:0002691)5.55715542
7positive regulation of pseudopodium assembly (GO:0031274)5.37768562
8positive regulation of respiratory burst (GO:0060267)5.23692406
9positive regulation of guanylate cyclase activity (GO:0031284)5.11285811
10eosinophil chemotaxis (GO:0048245)5.05599408
11angiotensin maturation (GO:0002003)4.83691011
12regulation of pseudopodium assembly (GO:0031272)4.80491238
13NADH metabolic process (GO:0006734)4.76391301
14negative regulation of epidermal cell differentiation (GO:0045605)4.60332311
15eosinophil migration (GO:0072677)4.51554651
16fructose metabolic process (GO:0006000)4.46060167
17phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.23058682
18regulation of isotype switching to IgG isotypes (GO:0048302)4.20626281
19regulation of chronic inflammatory response (GO:0002676)4.10476052
20nucleotide-sugar biosynthetic process (GO:0009226)4.04521322
21positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.98147369
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.97867549
23ATP synthesis coupled proton transport (GO:0015986)3.97867549
24regulation of immunoglobulin secretion (GO:0051023)3.97552379
25cellular response to cadmium ion (GO:0071276)3.97127343
26regulation of cGMP biosynthetic process (GO:0030826)3.89225401
27regulation of podosome assembly (GO:0071801)3.89045605
28regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.88407934
29regulation of respiratory burst (GO:0060263)3.74786584
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61372775
31sulfation (GO:0051923)3.59967019
32nucleoside diphosphate biosynthetic process (GO:0009133)3.59004224
33negative regulation of epidermis development (GO:0045683)3.54301485
34positive regulation of glycoprotein biosynthetic process (GO:0010560)3.50553413
35disruption of cells of other organism (GO:0044364)3.50439070
36killing of cells of other organism (GO:0031640)3.50439070
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48197420
38regulation of vitamin metabolic process (GO:0030656)3.47387343
39regulation of regulatory T cell differentiation (GO:0045589)3.47045219
40phosphatidylserine acyl-chain remodeling (GO:0036150)3.42865086
41regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.39627786
42viral transcription (GO:0019083)3.35532347
43cytidine deamination (GO:0009972)3.32202532
44cytidine metabolic process (GO:0046087)3.32202532
45cytidine catabolic process (GO:0006216)3.32202532
46vitamin A metabolic process (GO:0006776)3.29813226
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28043026
48complement activation, classical pathway (GO:0006958)3.27980719
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27356823
50regulation of cGMP metabolic process (GO:0030823)3.25811709
51defense response to fungus (GO:0050832)3.20302444
52positive regulation of DNA recombination (GO:0045911)3.10414694
53arginine metabolic process (GO:0006525)3.10026783
54glomerular filtration (GO:0003094)3.09875377
55negative regulation of leukocyte migration (GO:0002686)3.09223315
56antigen processing and presentation of endogenous antigen (GO:0019883)3.09097024
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.08842597
58phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.05162906
59intestinal absorption (GO:0050892)3.04904101
60transcytosis (GO:0045056)3.04378904
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04364655
62translational termination (GO:0006415)3.01623576
63negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.01592416
64protein targeting to ER (GO:0045047)3.00294232
65cotranslational protein targeting to membrane (GO:0006613)2.99304938
66positive regulation of isotype switching (GO:0045830)2.97562391
67fat-soluble vitamin biosynthetic process (GO:0042362)2.94722621
68vitamin transport (GO:0051180)2.94011209
69digestion (GO:0007586)2.92616747
70epoxygenase P450 pathway (GO:0019373)2.92050532
71response to zinc ion (GO:0010043)2.91747570
72phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91633405
73receptor guanylyl cyclase signaling pathway (GO:0007168)2.90061920
74positive regulation of cGMP biosynthetic process (GO:0030828)2.89292386
75establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87206338
76positive regulation of chemokine biosynthetic process (GO:0045080)2.87156221
77cobalamin metabolic process (GO:0009235)2.87064436
78protein localization to endoplasmic reticulum (GO:0070972)2.86610067
79regulation of proton transport (GO:0010155)2.86301948
80regulation of keratinocyte proliferation (GO:0010837)2.86289578
81positive regulation of glycoprotein metabolic process (GO:1903020)2.85922620
82chronic inflammatory response (GO:0002544)2.84110105
83regulation of chemokine biosynthetic process (GO:0045073)2.83636448
84rRNA modification (GO:0000154)2.83611929
85L-ascorbic acid metabolic process (GO:0019852)2.81651518
86positive regulation of immunoglobulin production (GO:0002639)2.81616278
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.79610566
88regulation of triglyceride catabolic process (GO:0010896)2.79298960
89drug metabolic process (GO:0017144)2.77980908
90oligosaccharide biosynthetic process (GO:0009312)2.77246442
91renal filtration (GO:0097205)2.75637362
92viral life cycle (GO:0019058)2.71967960
93translational elongation (GO:0006414)2.67108375
94activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.66647242
95regulation of keratinocyte differentiation (GO:0045616)2.65401463
96inner mitochondrial membrane organization (GO:0007007)2.63260806
97positive regulation of cellular amine metabolic process (GO:0033240)2.62805747
983-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60622730
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60622730
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59585472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.65177217
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.72083064
3HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.64488694
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.55654951
5SRY_22984422_ChIP-ChIP_TESTIS_Rat2.54599161
6GATA4_25053715_ChIP-Seq_YYC3_Human2.51148930
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45105261
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.39679238
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31651935
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.27501998
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.23729800
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.20875921
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.18347710
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18052551
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.16177351
16SA1_27219007_Chip-Seq_Bcells_Human2.02818567
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88441685
18BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.74337146
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73076877
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68037526
21STAT1_20625510_ChIP-Seq_HELA_Human1.66278980
22GATA6_25053715_ChIP-Seq_YYC3_Human1.61000412
23NANOG_20526341_ChIP-Seq_ESCs_Human1.55364823
24TET1_21451524_ChIP-Seq_MESCs_Mouse1.53335232
25EGR1_19032775_ChIP-ChIP_M12_Human1.52799981
26GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.51840621
27TAF2_19829295_ChIP-Seq_ESCs_Human1.51607575
28SOX2_20726797_ChIP-Seq_SW620_Human1.51204674
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50899251
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49010696
31DCP1A_22483619_ChIP-Seq_HELA_Human1.48256674
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47119236
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46556338
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45832716
35RBPJ_21746931_ChIP-Seq_IB4_Human1.42625594
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.40392139
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39725992
38BCOR_27268052_Chip-Seq_Bcells_Human1.38114804
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36357628
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35832234
41ERA_21632823_ChIP-Seq_H3396_Human1.34171640
42SOX2_21211035_ChIP-Seq_LN229_Human1.31804584
43HNFA_21074721_ChIP-Seq_CACO-2_Human1.31792821
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.31771630
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.30295617
46PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30260880
47GATA6_21074721_ChIP-Seq_CACO-2_Human1.28364832
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.27690212
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27196612
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26073970
51PHF8_20622853_ChIP-Seq_HELA_Human1.25899211
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25682005
53P53_21459846_ChIP-Seq_SAOS-2_Human1.25225081
54CTCF_27219007_Chip-Seq_Bcells_Human1.23958507
55RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22604806
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22107109
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21782617
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.20982409
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.19455868
60MYC_19829295_ChIP-Seq_ESCs_Human1.19107300
61CTCF_20526341_ChIP-Seq_ESCs_Human1.18886583
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18871791
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16965359
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16503400
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16354298
66GATA3_26560356_Chip-Seq_TH2_Human1.16204492
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15706843
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.15706843
69BCL6_27268052_Chip-Seq_Bcells_Human1.15246464
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13302381
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.13203840
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12585589
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11634305
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10900215
75ETV1_20927104_ChIP-Seq_GIST48_Human1.10335263
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09919413
77VDR_23849224_ChIP-Seq_CD4+_Human1.09287928
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09154379
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08169115
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07961053
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05720516
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03917499
83CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03746256
84TP53_22573176_ChIP-Seq_HFKS_Human1.02257375
85AR_20517297_ChIP-Seq_VCAP_Human1.01763155
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00611477
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00541062
88P300_27268052_Chip-Seq_Bcells_Human1.00515137
89CDX2_22108803_ChIP-Seq_LS180_Human0.99284485
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98019528
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.96737943
92E2F1_20622854_ChIP-Seq_HELA_Human0.96037161
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96004169
94NCOR_22424771_ChIP-Seq_293T_Human0.95423769
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.94861387
96NFYB_21822215_ChIP-Seq_K562_Human0.94648209
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93576916
98LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92402018
99CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92097526
100CEBPB_22108803_ChIP-Seq_LS180_Human0.91945648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.03386188
2MP0005360_urolithiasis6.01178515
3MP0001666_abnormal_nutrient_absorption3.78463388
4MP0001873_stomach_inflammation3.57792768
5MP0010155_abnormal_intestine_physiology3.06276351
6MP0002139_abnormal_hepatobiliary_system2.91960514
7MP0001835_abnormal_antigen_presentation2.85100812
8MP0003183_abnormal_peptide_metabolism2.70085075
9MP0004019_abnormal_vitamin_homeostasis2.64835460
10MP0000685_abnormal_immune_system2.53800019
11MP0000566_synostosis2.43040216
12MP0005085_abnormal_gallbladder_physiolo2.38034616
13MP0001188_hyperpigmentation2.37566271
14MP0003718_maternal_effect2.19581636
15MP0005387_immune_system_phenotype2.11432051
16MP0001790_abnormal_immune_system2.11432051
17MP0003866_abnormal_defecation2.06892579
18MP0000490_abnormal_crypts_of2.05173174
19MP0006082_CNS_inflammation2.03796385
20MP0001348_abnormal_lacrimal_gland2.02454206
21MP0002876_abnormal_thyroid_physiology2.01207719
22MP0009840_abnormal_foam_cell1.98901002
23MP0005671_abnormal_response_to1.89025001
24MP0005409_darkened_coat_color1.79919489
25MP0005451_abnormal_body_composition1.77808057
26MP0009785_altered_susceptibility_to1.72950048
27MP0002148_abnormal_hypersensitivity_rea1.72068169
28MP0009333_abnormal_splenocyte_physiolog1.66088925
29MP0005645_abnormal_hypothalamus_physiol1.58601435
30MP0000678_abnormal_parathyroid_gland1.54942008
31MP0005332_abnormal_amino_acid1.51198457
32MP0000477_abnormal_intestine_morphology1.50309619
33MP0008872_abnormal_physiological_respon1.48775880
34MP0010234_abnormal_vibrissa_follicle1.48678054
35MP0005166_decreased_susceptibility_to1.48523517
36MP0001663_abnormal_digestive_system1.44476663
37MP0000604_amyloidosis1.42972495
38MP0004264_abnormal_extraembryonic_tissu1.41385988
39MP0002166_altered_tumor_susceptibility1.40986985
40MP0001664_abnormal_digestion1.38295058
41MP0002254_reproductive_system_inflammat1.35262757
42MP0002938_white_spotting1.34859442
43MP0009643_abnormal_urine_homeostasis1.34307329
44MP0005025_abnormal_response_to1.30126037
45MP0001845_abnormal_inflammatory_respons1.29003784
46MP0003806_abnormal_nucleotide_metabolis1.26493347
47MP0000538_abnormal_urinary_bladder1.24332728
48MP0001765_abnormal_ion_homeostasis1.21709334
49MP0003879_abnormal_hair_cell1.21237617
50MP0002138_abnormal_hepatobiliary_system1.17726722
51MP0002006_tumorigenesis1.16403484
52MP0005365_abnormal_bile_salt1.13616422
53MP0005000_abnormal_immune_tolerance1.11084376
54MP0001800_abnormal_humoral_immune1.10649727
55MP0004147_increased_porphyrin_level1.08951787
56MP0003693_abnormal_embryo_hatching1.06695414
57MP0005448_abnormal_energy_balance1.03248303
58MP0005310_abnormal_salivary_gland1.02430213
59MP0005381_digestive/alimentary_phenotyp1.01928957
60MP0002136_abnormal_kidney_physiology1.01349200
61MP0005408_hypopigmentation1.00517788
62MP0003959_abnormal_lean_body0.99867017
63MP0000465_gastrointestinal_hemorrhage0.99235531
64MP0003300_gastrointestinal_ulcer0.98729986
65MP0005410_abnormal_fertilization0.98490827
66MP0003638_abnormal_response/metabolism_0.98105322
67MP0003763_abnormal_thymus_physiology0.95856605
68MP0010329_abnormal_lipoprotein_level0.94651636
69MP0003436_decreased_susceptibility_to0.91660027
70MP0004957_abnormal_blastocyst_morpholog0.89955682
71MP0003315_abnormal_perineum_morphology0.87182818
72MP0008875_abnormal_xenobiotic_pharmacok0.86818894
73MP0002796_impaired_skin_barrier0.85468000
74MP0005636_abnormal_mineral_homeostasis0.83999720
75MP0010352_gastrointestinal_tract_polyps0.83794632
76MP0000015_abnormal_ear_pigmentation0.83282825
77MP0001502_abnormal_circadian_rhythm0.83264002
78MP0010386_abnormal_urinary_bladder0.83022549
79MP0001881_abnormal_mammary_gland0.82976900
80MP0002723_abnormal_immune_serum0.82582404
81MP0001819_abnormal_immune_cell0.82330889
82MP0001764_abnormal_homeostasis0.82003042
83MP0003252_abnormal_bile_duct0.81430078
84MP0002420_abnormal_adaptive_immunity0.79310081
85MP0001501_abnormal_sleep_pattern0.79179461
86MP0001533_abnormal_skeleton_physiology0.77545806
87MP0005165_increased_susceptibility_to0.72489076
88MP0002736_abnormal_nociception_after0.69131365
89MP0002452_abnormal_antigen_presenting0.65952611
90MP0003950_abnormal_plasma_membrane0.65605846
91MP0005584_abnormal_enzyme/coenzyme_acti0.63085668
92MP0008469_abnormal_protein_level0.63010841
93MP0000537_abnormal_urethra_morphology0.62908118
94MP0001756_abnormal_urination0.62097501
95MP0003938_abnormal_ear_development0.62025980
96MP0005535_abnormal_body_temperature0.61846709
97MP0009764_decreased_sensitivity_to0.61826625
98MP0001485_abnormal_pinna_reflex0.61720358
99MP0002098_abnormal_vibrissa_morphology0.60611043
100MP0002277_abnormal_respiratory_mucosa0.58570426

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)7.01887496
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.35071785
3Abnormality of the vitamin B12 metabolism (HP:0004341)4.05839499
4Abnormality of vitamin B metabolism (HP:0004340)3.98275413
5Hydroxyprolinuria (HP:0003080)3.73978373
6Abnormality of proline metabolism (HP:0010907)3.73978373
7Chronic diarrhea (HP:0002028)3.61620075
8Nausea (HP:0002018)3.60425111
9Glycosuria (HP:0003076)3.59277636
10Abnormality of urine glucose concentration (HP:0011016)3.59277636
11Proximal tubulopathy (HP:0000114)3.57086350
12Confusion (HP:0001289)3.40682201
13Abnormality of purine metabolism (HP:0004352)3.38359421
14Hyperphosphaturia (HP:0003109)3.36333852
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25790154
16Systemic lupus erythematosus (HP:0002725)3.25030052
17Congenital sensorineural hearing impairment (HP:0008527)3.21109059
18Hyperuricemia (HP:0002149)3.10792410
19Increased purine levels (HP:0004368)3.10792410
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05299977
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05299977
22Hypoalbuminemia (HP:0003073)2.96175019
23Abnormal albumin level (HP:0012116)2.96175019
24External ophthalmoplegia (HP:0000544)2.88983907
25Testicular atrophy (HP:0000029)2.88359150
26Abnormal urine phosphate concentration (HP:0012599)2.88342907
27Hypobetalipoproteinemia (HP:0003563)2.86817209
28Decreased circulating renin level (HP:0003351)2.84348034
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77743985
30Dicarboxylic aciduria (HP:0003215)2.77743985
31Increased intramyocellular lipid droplets (HP:0012240)2.73689406
32Macrocytic anemia (HP:0001972)2.73496620
33Abnormality of vitamin metabolism (HP:0100508)2.72067215
34Abnormal mitochondria in muscle tissue (HP:0008316)2.70063364
35Methylmalonic aciduria (HP:0012120)2.69988864
36Abnormality of nucleobase metabolism (HP:0010932)2.69871112
37Stomatitis (HP:0010280)2.68713777
38Acute necrotizing encephalopathy (HP:0006965)2.64365312
39Increased muscle lipid content (HP:0009058)2.61693605
40Increased hepatocellular lipid droplets (HP:0006565)2.57752301
41Renal tubular dysfunction (HP:0000124)2.56896341
42Autoimmune thrombocytopenia (HP:0001973)2.56608282
43Lipid accumulation in hepatocytes (HP:0006561)2.53705945
44Lethargy (HP:0001254)2.52088152
45Abnormality of B cell number (HP:0010975)2.50242679
46Posterior subcapsular cataract (HP:0007787)2.49988058
47Acute encephalopathy (HP:0006846)2.49300809
48Megaloblastic anemia (HP:0001889)2.48978408
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45341518
50Renal tubular acidosis (HP:0001947)2.45219756
51B lymphocytopenia (HP:0010976)2.44552904
52Fat malabsorption (HP:0002630)2.41883414
53Gout (HP:0001997)2.40513210
54Abnormality of T cell physiology (HP:0011840)2.36953307
55Nephrolithiasis (HP:0000787)2.32899397
56Hypoplasia of the ulna (HP:0003022)2.32694651
57Hypophosphatemia (HP:0002148)2.32224201
58IgG deficiency (HP:0004315)2.29638653
59Abnormality of renin-angiotensin system (HP:0000847)2.28864112
60Alkalosis (HP:0001948)2.28142151
61Glomerulonephritis (HP:0000099)2.22379484
62Delayed CNS myelination (HP:0002188)2.20254113
63Progressive macrocephaly (HP:0004481)2.20052614
64Cerebral edema (HP:0002181)2.19285025
65Flattened epiphyses (HP:0003071)2.19108012
66Mitochondrial inheritance (HP:0001427)2.17157824
67Vomiting (HP:0002013)2.16155892
68Hypoplasia of the radius (HP:0002984)2.14452381
69Tongue fasciculations (HP:0001308)2.14173747
70Small epiphyses (HP:0010585)2.13614414
71Aplasia/Hypoplasia of the ulna (HP:0006495)2.12834914
72Metabolic acidosis (HP:0001942)2.12086731
73Renal Fanconi syndrome (HP:0001994)2.11082351
74Metabolic alkalosis (HP:0200114)2.09040170
75Exertional dyspnea (HP:0002875)2.02954218
76Pigmentary retinal degeneration (HP:0001146)2.02663409
77Irritability (HP:0000737)2.01896844
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00196598
79Hepatocellular necrosis (HP:0001404)1.99988261
80Conical tooth (HP:0000698)1.98829007
81Pustule (HP:0200039)1.98277782
82Abnormality of serine family amino acid metabolism (HP:0010894)1.97988726
83Abnormality of glycine metabolism (HP:0010895)1.97988726
84Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97897263
85Myopathic facies (HP:0002058)1.95746696
86Abnormality of small intestinal villus morphology (HP:0011472)1.95648230
87Villous atrophy (HP:0011473)1.95648230
88Steatorrhea (HP:0002570)1.94325577
89Autoimmune hemolytic anemia (HP:0001890)1.94085099
90Hepatic necrosis (HP:0002605)1.93951134
91Reticulocytopenia (HP:0001896)1.93648126
92Abnormality of magnesium homeostasis (HP:0004921)1.92052266
93Neck muscle weakness (HP:0000467)1.91695512
943-Methylglutaconic aciduria (HP:0003535)1.89648914
95Increased IgM level (HP:0003496)1.88157242
96Abnormal hair laboratory examination (HP:0003328)1.88029694
97Hyperparathyroidism (HP:0000843)1.87881301
98Tetraparesis (HP:0002273)1.81495863
99Widely patent fontanelles and sutures (HP:0004492)1.81269518
100IgA deficiency (HP:0002720)1.80900700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.38980309
2MAP3K124.21659929
3EPHB23.86405598
4ACVR1B3.56455985
5CDK193.52511807
6TXK3.40509110
7STK163.26174209
8STK242.59084314
9MST42.50856545
10PBK2.49978714
11MAP3K112.48628863
12SIK32.34260026
13MAP2K62.14899263
14MYLK2.13449914
15MST1R1.92087780
16ZAP701.81774657
17GRK61.78918539
18SRPK11.76545142
19PRKG21.63529416
20NEK11.57441719
21EPHA21.54856796
22SCYL21.47464379
23OXSR11.45553004
24MAP4K21.45091680
25STK391.42948093
26NME11.40093579
27MAP3K31.26832949
28ADRBK21.26202987
29TNIK1.25095946
30WNK41.19455711
31NME21.16455476
32PASK1.13854890
33DYRK31.05605599
34PDK21.03800325
35PRKD31.01288397
36FGFR10.99836203
37VRK20.94043104
38STK40.91688830
39BMPR20.89656765
40CAMK2G0.89420646
41GRK10.85890006
42PTK60.79995169
43SIK10.78571392
44TLK10.78135671
45PAK40.76381156
46MARK30.75801794
47RPS6KA40.75213006
48TEC0.72271007
49SIK20.70714923
50IKBKE0.70688068
51TESK20.70215371
52ILK0.69690844
53IKBKB0.68511329
54ERN10.67054519
55STK38L0.63712122
56TAOK20.62785940
57MAP3K10.62613845
58LRRK20.61972197
59ITK0.61160815
60ADRBK10.59018287
61KDR0.58883148
62TSSK60.57085084
63PRKCQ0.55963699
64BUB10.54083646
65EPHA40.52449933
66TRIM280.51494091
67PRKD20.51481960
68ABL20.51433772
69FLT30.50920195
70ARAF0.49181222
71MAP3K100.48929360
72PIK3CG0.47244534
73CSK0.44253815
74CAMK2D0.43924707
75ZAK0.41137620
76PRKCZ0.39468119
77PRKCA0.39375051
78DDR20.38124678
79PLK40.37872010
80CSNK2A20.36641142
81INSRR0.34482838
82PRKG10.34214128
83BTK0.33791694
84TESK10.33524644
85LCK0.32669391
86CAMK2A0.32347705
87STK30.31915371
88CSNK1A10.31049602
89GSK3A0.30873257
90IGF1R0.29942794
91MAP2K20.29731296
92PRKACG0.28200460
93MAP3K50.28160409
94AKT30.27005076
95FGFR40.26908198
96MATK0.26665257
97PRKCD0.24499291
98TYRO30.23952162
99TGFBR20.22922452
100TBK10.20924487

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.45996669
2Asthma_Homo sapiens_hsa053104.17066845
3Fat digestion and absorption_Homo sapiens_hsa049753.46434762
4Vitamin digestion and absorption_Homo sapiens_hsa049773.26559511
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.20844345
6Allograft rejection_Homo sapiens_hsa053302.99084338
7Fructose and mannose metabolism_Homo sapiens_hsa000512.84839490
8Autoimmune thyroid disease_Homo sapiens_hsa053202.82050070
9Mineral absorption_Homo sapiens_hsa049782.51244868
10Sulfur metabolism_Homo sapiens_hsa009202.50282484
11Ribosome_Homo sapiens_hsa030102.43792628
12Graft-versus-host disease_Homo sapiens_hsa053322.19471343
13Renin-angiotensin system_Homo sapiens_hsa046142.15151134
14Arginine biosynthesis_Homo sapiens_hsa002202.10916744
15Proteasome_Homo sapiens_hsa030501.93129856
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74572307
17Caffeine metabolism_Homo sapiens_hsa002321.72551539
18Type I diabetes mellitus_Homo sapiens_hsa049401.65680596
19Linoleic acid metabolism_Homo sapiens_hsa005911.64705473
20Oxidative phosphorylation_Homo sapiens_hsa001901.64103684
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64004398
22Glutathione metabolism_Homo sapiens_hsa004801.59836304
23Sulfur relay system_Homo sapiens_hsa041221.58775108
24Folate biosynthesis_Homo sapiens_hsa007901.57681979
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53926342
26Chemical carcinogenesis_Homo sapiens_hsa052041.52545449
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49661858
28Arachidonic acid metabolism_Homo sapiens_hsa005901.43180986
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26126407
30Antigen processing and presentation_Homo sapiens_hsa046121.22649015
31Protein digestion and absorption_Homo sapiens_hsa049741.17945292
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.16277782
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14786511
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.14483124
35Parkinsons disease_Homo sapiens_hsa050121.12291354
36Arginine and proline metabolism_Homo sapiens_hsa003301.12179971
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10960771
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10324360
39Retinol metabolism_Homo sapiens_hsa008301.05986813
40Primary immunodeficiency_Homo sapiens_hsa053401.04802478
41Glycerolipid metabolism_Homo sapiens_hsa005611.02287159
42Protein export_Homo sapiens_hsa030601.00813739
43Hematopoietic cell lineage_Homo sapiens_hsa046400.92339862
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88784646
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86346623
46Histidine metabolism_Homo sapiens_hsa003400.83340745
47Pyrimidine metabolism_Homo sapiens_hsa002400.82683701
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81575455
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81079234
50Alzheimers disease_Homo sapiens_hsa050100.80667249
51Ether lipid metabolism_Homo sapiens_hsa005650.80437099
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.80090287
53Huntingtons disease_Homo sapiens_hsa050160.79745073
54Rheumatoid arthritis_Homo sapiens_hsa053230.78783010
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78741375
56PPAR signaling pathway_Homo sapiens_hsa033200.73917638
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.71772242
58Starch and sucrose metabolism_Homo sapiens_hsa005000.70854165
59RNA polymerase_Homo sapiens_hsa030200.70752062
60Galactose metabolism_Homo sapiens_hsa000520.70329798
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68672596
62Nitrogen metabolism_Homo sapiens_hsa009100.65806160
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63789888
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63325969
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62781551
66Viral myocarditis_Homo sapiens_hsa054160.61986805
67Bile secretion_Homo sapiens_hsa049760.60517640
68Staphylococcus aureus infection_Homo sapiens_hsa051500.59638647
69Fatty acid degradation_Homo sapiens_hsa000710.54268965
70T cell receptor signaling pathway_Homo sapiens_hsa046600.53458914
71Regulation of autophagy_Homo sapiens_hsa041400.52312085
72Basal transcription factors_Homo sapiens_hsa030220.50525364
73Pancreatic secretion_Homo sapiens_hsa049720.50235805
74Metabolic pathways_Homo sapiens_hsa011000.49100877
75Chemokine signaling pathway_Homo sapiens_hsa040620.47334726
76Cardiac muscle contraction_Homo sapiens_hsa042600.47216087
77Pertussis_Homo sapiens_hsa051330.45647892
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44941659
79Vitamin B6 metabolism_Homo sapiens_hsa007500.44156387
80Peroxisome_Homo sapiens_hsa041460.38513629
81Tryptophan metabolism_Homo sapiens_hsa003800.38513581
82TNF signaling pathway_Homo sapiens_hsa046680.38406699
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33866881
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33113170
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30157828
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29134287
87Purine metabolism_Homo sapiens_hsa002300.28704722
88Collecting duct acid secretion_Homo sapiens_hsa049660.27664814
89Phototransduction_Homo sapiens_hsa047440.25933467
90Vibrio cholerae infection_Homo sapiens_hsa051100.25471464
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22555604
92Sphingolipid metabolism_Homo sapiens_hsa006000.17546369
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.17351046
94Renin secretion_Homo sapiens_hsa049240.15599186
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15472332
96Herpes simplex infection_Homo sapiens_hsa051680.15200561
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.11891654
98Leishmaniasis_Homo sapiens_hsa051400.10835467
99Thyroid hormone synthesis_Homo sapiens_hsa049180.10461595
100Prion diseases_Homo sapiens_hsa050200.10347958

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