TPT1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.19935097
2positive regulation of interleukin-17 production (GO:0032740)5.89746481
3ribosomal large subunit biogenesis (GO:0042273)5.71394603
4viral transcription (GO:0019083)5.66866979
5translational termination (GO:0006415)5.46408256
6drinking behavior (GO:0042756)4.95680096
7translational elongation (GO:0006414)4.80590928
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.76028945
9cotranslational protein targeting to membrane (GO:0006613)4.67776302
10ribosomal small subunit biogenesis (GO:0042274)4.62037830
11protein targeting to ER (GO:0045047)4.60241464
12cellular response to ATP (GO:0071318)4.55790306
13maturation of SSU-rRNA (GO:0030490)4.54155101
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42422121
15protein localization to endoplasmic reticulum (GO:0070972)4.37168751
16cellular ketone body metabolic process (GO:0046950)4.20269686
17behavioral response to nicotine (GO:0035095)4.19527219
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.14657716
19viral life cycle (GO:0019058)4.08861403
20positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.08365361
21DNA deamination (GO:0045006)4.05930748
22cellular protein complex disassembly (GO:0043624)4.01875742
23translational initiation (GO:0006413)4.00255134
24regulation of isotype switching to IgG isotypes (GO:0048302)3.95358298
25grooming behavior (GO:0007625)3.94902477
26cell wall macromolecule metabolic process (GO:0044036)3.91836840
27negative regulation of appetite (GO:0032099)3.89613017
28negative regulation of response to food (GO:0032096)3.89613017
29regulation of immunoglobulin secretion (GO:0051023)3.88244095
30regulation of feeding behavior (GO:0060259)3.73660148
31ketone body metabolic process (GO:1902224)3.72322027
32regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.67636498
33negative regulation of digestive system process (GO:0060457)3.62293554
34positive regulation of vascular permeability (GO:0043117)3.59839291
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51775078
36ribonucleoprotein complex biogenesis (GO:0022613)3.47177379
37translation (GO:0006412)3.43840506
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40438094
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38475498
40water-soluble vitamin biosynthetic process (GO:0042364)3.33114460
41phosphate ion homeostasis (GO:0055062)3.32322021
42trivalent inorganic anion homeostasis (GO:0072506)3.32322021
43regulation of interleukin-17 production (GO:0032660)3.30231069
44hormone catabolic process (GO:0042447)3.22361076
45ncRNA 3-end processing (GO:0043628)3.21616296
46purine nucleotide salvage (GO:0032261)3.20963142
47positive regulation of DNA recombination (GO:0045911)3.19386128
48protein complex disassembly (GO:0043241)3.16120593
49regulation of regulatory T cell differentiation (GO:0045589)3.15498779
50carnitine transmembrane transport (GO:1902603)3.12581208
51positive regulation of digestive system process (GO:0060456)3.09074752
52cellular component biogenesis (GO:0044085)3.08321905
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.07903890
54macromolecular complex disassembly (GO:0032984)3.04407211
55amino-acid betaine transport (GO:0015838)3.02262031
56carnitine transport (GO:0015879)3.02262031
57labyrinthine layer development (GO:0060711)2.99389412
58chaperone-mediated protein transport (GO:0072321)2.97986115
59positive regulation of uterine smooth muscle contraction (GO:0070474)2.95981792
60positive regulation of isotype switching (GO:0045830)2.94271851
61organic cation transport (GO:0015695)2.92455580
62regulation of appetite (GO:0032098)2.92198062
63mRNA catabolic process (GO:0006402)2.91776565
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90795790
65response to pheromone (GO:0019236)2.89577405
66protein neddylation (GO:0045116)2.89203036
67aggressive behavior (GO:0002118)2.88180585
68purine-containing compound salvage (GO:0043101)2.84648332
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.82401582
70male meiosis I (GO:0007141)2.81394687
71protein targeting to membrane (GO:0006612)2.80712879
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.74969634
73NADH dehydrogenase complex assembly (GO:0010257)2.74969634
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74969634
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71490698
76ATP synthesis coupled proton transport (GO:0015986)2.71490698
77piRNA metabolic process (GO:0034587)2.68893709
78protein complex biogenesis (GO:0070271)2.67628970
79negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65317417
80positive regulation of cell fate commitment (GO:0010455)2.64003469
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63774115
82RNA catabolic process (GO:0006401)2.61529991
83negative regulation of B cell apoptotic process (GO:0002903)2.61054566
84glucosamine-containing compound catabolic process (GO:1901072)2.59507776
85determination of adult lifespan (GO:0008340)2.59069081
86interferon-gamma production (GO:0032609)2.59017505
87rRNA processing (GO:0006364)2.57657754
88positive regulation of T cell differentiation in thymus (GO:0033089)2.57368135
89regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56631103
90rRNA metabolic process (GO:0016072)2.53810228
91detection of light stimulus involved in sensory perception (GO:0050962)2.49358159
92detection of light stimulus involved in visual perception (GO:0050908)2.49358159
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49053426
94purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.46716033
95aldehyde catabolic process (GO:0046185)2.45885626
96RNA phosphodiester bond hydrolysis (GO:0090501)2.44771911
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43957001
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43957001
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.42943301
100negative regulation of T-helper cell differentiation (GO:0045623)2.42943301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.86809297
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41450935
3IGF1R_20145208_ChIP-Seq_DFB_Human3.37236386
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.26770247
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25927082
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16812285
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93233834
8GATA1_22025678_ChIP-Seq_K562_Human2.89788806
9ZNF274_21170338_ChIP-Seq_K562_Hela2.69172888
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46918329
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.26203309
12EWS_26573619_Chip-Seq_HEK293_Human2.14863326
13EZH2_22144423_ChIP-Seq_EOC_Human2.12402446
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.99797605
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.96861845
16FUS_26573619_Chip-Seq_HEK293_Human1.95918159
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94190651
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.93512545
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.90214436
20MYC_18940864_ChIP-ChIP_HL60_Human1.88185200
21VDR_23849224_ChIP-Seq_CD4+_Human1.88118366
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70543017
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68958321
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68789923
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66296203
26FOXA1_27270436_Chip-Seq_PROSTATE_Human1.65006800
27FOXA1_25329375_ChIP-Seq_VCAP_Human1.65006800
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57977391
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.55356051
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54113135
31ELK1_19687146_ChIP-ChIP_HELA_Human1.54097152
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53053611
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53000349
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49090782
35TP53_22573176_ChIP-Seq_HFKS_Human1.48092678
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47962931
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44973694
38SOX2_19829295_ChIP-Seq_ESCs_Human1.44469169
39NANOG_19829295_ChIP-Seq_ESCs_Human1.44469169
40GBX2_23144817_ChIP-Seq_PC3_Human1.43893220
41NCOR_22424771_ChIP-Seq_293T_Human1.43700426
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43179814
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43017169
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41540180
45FOXP3_21729870_ChIP-Seq_TREG_Human1.41357197
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39824236
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37141947
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36244563
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35734960
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33032894
51TAF15_26573619_Chip-Seq_HEK293_Human1.32579099
52CBP_20019798_ChIP-Seq_JUKART_Human1.31787708
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31787708
54RUNX_20019798_ChIP-Seq_JUKART_Human1.29492837
55ER_23166858_ChIP-Seq_MCF-7_Human1.28109671
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.27730629
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26750293
58GATA3_26560356_Chip-Seq_TH2_Human1.26516538
59AR_20517297_ChIP-Seq_VCAP_Human1.26178194
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25552906
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22011227
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21132486
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20669586
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16542464
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.16262345
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.14188456
67TTF2_22483619_ChIP-Seq_HELA_Human1.12819938
68P300_19829295_ChIP-Seq_ESCs_Human1.11864961
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11510426
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10799331
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10303351
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09708263
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07505031
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04314855
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02833607
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.01534556
77FLI1_21867929_ChIP-Seq_TH2_Mouse0.99772978
78RNF2_27304074_Chip-Seq_NSC_Mouse0.99729983
79BP1_19119308_ChIP-ChIP_Hs578T_Human0.99221290
80P53_21459846_ChIP-Seq_SAOS-2_Human0.99098126
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98502446
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98201220
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95980272
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95723123
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95554970
86WDR5_24793694_ChIP-Seq_LNCAP_Human0.93781465
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93598297
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92996144
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.92977935
90ERA_21632823_ChIP-Seq_H3396_Human0.92147278
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90364031
92BCAT_22108803_ChIP-Seq_LS180_Human0.89824675
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.89323726
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.89166467
95HOXB7_26014856_ChIP-Seq_BT474_Human0.88986223
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88901043
97TCF4_22108803_ChIP-Seq_LS180_Human0.88410003
98GATA3_21867929_ChIP-Seq_TH1_Mouse0.88220498
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.87817242
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.86906433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.24706055
2MP0001835_abnormal_antigen_presentation3.35018702
3MP0000678_abnormal_parathyroid_gland2.95380017
4MP0005084_abnormal_gallbladder_morpholo2.53095243
5MP0008877_abnormal_DNA_methylation2.34883373
6MP0003646_muscle_fatigue2.17692829
7MP0002138_abnormal_hepatobiliary_system2.17538557
8MP0008872_abnormal_physiological_respon2.16367464
9MP0006072_abnormal_retinal_apoptosis2.10073972
10MP0004147_increased_porphyrin_level2.03514802
11MP0001188_hyperpigmentation1.95860434
12MP0005645_abnormal_hypothalamus_physiol1.93576060
13MP0005389_reproductive_system_phenotype1.92273711
14MP0005551_abnormal_eye_electrophysiolog1.91619884
15MP0008995_early_reproductive_senescence1.88352404
16MP0006292_abnormal_olfactory_placode1.88110282
17MP0005075_abnormal_melanosome_morpholog1.87143092
18MP0002396_abnormal_hematopoietic_system1.83232396
19MP0003567_abnormal_fetal_cardiomyocyte1.82273815
20MP0002160_abnormal_reproductive_system1.80546944
21MP0001529_abnormal_vocalization1.78969981
22MP0001873_stomach_inflammation1.76982356
23MP0009333_abnormal_splenocyte_physiolog1.75153398
24MP0005387_immune_system_phenotype1.66696961
25MP0001790_abnormal_immune_system1.66696961
26MP0001986_abnormal_taste_sensitivity1.63775794
27MP0001919_abnormal_reproductive_system1.61922584
28MP0003786_premature_aging1.61649033
29MP0005671_abnormal_response_to1.52995891
30MP0001485_abnormal_pinna_reflex1.51878802
31MP0001968_abnormal_touch/_nociception1.48579930
32MP0002837_dystrophic_cardiac_calcinosis1.43986080
33MP0003806_abnormal_nucleotide_metabolis1.43296984
34MP0002735_abnormal_chemical_nociception1.43147383
35MP0002148_abnormal_hypersensitivity_rea1.42445540
36MP0001348_abnormal_lacrimal_gland1.38592698
37MP0010386_abnormal_urinary_bladder1.38094327
38MP0003195_calcinosis1.36978002
39MP0003283_abnormal_digestive_organ1.32592311
40MP0003252_abnormal_bile_duct1.28797476
41MP0000685_abnormal_immune_system1.21257536
42MP0006276_abnormal_autonomic_nervous1.19119115
43MP0000383_abnormal_hair_follicle1.19100880
44MP0000372_irregular_coat_pigmentation1.18895464
45MP0005085_abnormal_gallbladder_physiolo1.18249379
46MP0001800_abnormal_humoral_immune1.16920014
47MP0004484_altered_response_of1.15085911
48MP0005646_abnormal_pituitary_gland1.13328359
49MP0008875_abnormal_xenobiotic_pharmacok1.12743161
50MP0000604_amyloidosis1.12354034
51MP0005000_abnormal_immune_tolerance1.10586416
52MP0004142_abnormal_muscle_tone1.09514579
53MP0000013_abnormal_adipose_tissue1.04207626
54MP0002102_abnormal_ear_morphology1.00997872
55MP0002876_abnormal_thyroid_physiology1.00977418
56MP0004885_abnormal_endolymph1.00676497
57MP0005636_abnormal_mineral_homeostasis0.99252671
58MP0009785_altered_susceptibility_to0.98554611
59MP0004145_abnormal_muscle_electrophysio0.97231182
60MP0002405_respiratory_system_inflammati0.96278580
61MP0001664_abnormal_digestion0.96145559
62MP0005025_abnormal_response_to0.95899115
63MP0000631_abnormal_neuroendocrine_gland0.95475442
64MP0002723_abnormal_immune_serum0.95126655
65MP0001905_abnormal_dopamine_level0.95042185
66MP0001765_abnormal_ion_homeostasis0.94339966
67MP0001764_abnormal_homeostasis0.94305001
68MP0006036_abnormal_mitochondrial_physio0.93869330
69MP0001440_abnormal_grooming_behavior0.91787103
70MP0004215_abnormal_myocardial_fiber0.91480847
71MP0002127_abnormal_cardiovascular_syste0.89543469
72MP0002693_abnormal_pancreas_physiology0.89447402
73MP0003878_abnormal_ear_physiology0.86760755
74MP0005377_hearing/vestibular/ear_phenot0.86760755
75MP0006082_CNS_inflammation0.85256725
76MP0005253_abnormal_eye_physiology0.85219275
77MP0000230_abnormal_systemic_arterial0.84473356
78MP0004742_abnormal_vestibular_system0.82871490
79MP0002420_abnormal_adaptive_immunity0.82746658
80MP0002272_abnormal_nervous_system0.82172280
81MP0002234_abnormal_pharynx_morphology0.81937545
82MP0001963_abnormal_hearing_physiology0.81776572
83MP0002398_abnormal_bone_marrow0.81770460
84MP0009643_abnormal_urine_homeostasis0.80376757
85MP0001663_abnormal_digestive_system0.79831812
86MP0001819_abnormal_immune_cell0.79464073
87MP0003866_abnormal_defecation0.79205883
88MP0003936_abnormal_reproductive_system0.79025765
89MP0002095_abnormal_skin_pigmentation0.78975445
90MP0005464_abnormal_platelet_physiology0.77276334
91MP0000716_abnormal_immune_system0.76790662
92MP0000049_abnormal_middle_ear0.76001395
93MP0003959_abnormal_lean_body0.74777690
94MP0001486_abnormal_startle_reflex0.73571075
95MP0005332_abnormal_amino_acid0.72545501
96MP0002452_abnormal_antigen_presenting0.70771701
97MP0001881_abnormal_mammary_gland0.70493316
98MP0002163_abnormal_gland_morphology0.69089844
99MP0005410_abnormal_fertilization0.67866093
100MP0009745_abnormal_behavioral_response0.67523348

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.69139558
2Renal Fanconi syndrome (HP:0001994)3.97962665
3Decreased electroretinogram (ERG) amplitude (HP:0000654)3.81132318
4Abnormality of B cell number (HP:0010975)3.71644859
5B lymphocytopenia (HP:0010976)3.61911439
6Abnormality of the costochondral junction (HP:0000919)3.60869080
7Reticulocytopenia (HP:0001896)3.55143986
8Abnormality of cells of the erythroid lineage (HP:0012130)3.49270578
9Tetany (HP:0001281)3.46010949
10Stomatitis (HP:0010280)3.44721154
11Hyperglycinemia (HP:0002154)3.43120477
12Elevated erythrocyte sedimentation rate (HP:0003565)3.40294319
13Decreased central vision (HP:0007663)3.31898564
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25017873
15Stenosis of the external auditory canal (HP:0000402)3.23809619
16Abnormal drinking behavior (HP:0030082)3.19796009
17Polydipsia (HP:0001959)3.19796009
18Macrocytic anemia (HP:0001972)3.10378608
19Methylmalonic acidemia (HP:0002912)3.08500500
20Pendular nystagmus (HP:0012043)3.06511369
21Congenital stationary night blindness (HP:0007642)3.06205552
22Abnormality of urine glucose concentration (HP:0011016)2.91498592
23Glycosuria (HP:0003076)2.91498592
24Attenuation of retinal blood vessels (HP:0007843)2.87099780
25Failure to thrive in infancy (HP:0001531)2.83820644
26Increased IgM level (HP:0003496)2.83787633
27Type 2 muscle fiber atrophy (HP:0003554)2.82080216
28Pancreatic cysts (HP:0001737)2.80501682
29Abnormal number of erythroid precursors (HP:0012131)2.67904609
30Abnormality of serum amino acid levels (HP:0003112)2.64903065
31Increased hepatocellular lipid droplets (HP:0006565)2.63703165
32Abnormal rod and cone electroretinograms (HP:0008323)2.59466966
33Mitochondrial inheritance (HP:0001427)2.53094847
34Acute necrotizing encephalopathy (HP:0006965)2.52908051
35Pallor (HP:0000980)2.52292177
36Lipid accumulation in hepatocytes (HP:0006561)2.52008480
37Optic disc pallor (HP:0000543)2.52003933
38Abnormality of alanine metabolism (HP:0010916)2.50895271
39Hyperalaninemia (HP:0003348)2.50895271
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50895271
41Keratoconus (HP:0000563)2.49405069
42Increased corneal curvature (HP:0100692)2.49405069
43Metaphyseal dysplasia (HP:0100255)2.49274811
44Hypophosphatemic rickets (HP:0004912)2.47501694
45Increased CSF lactate (HP:0002490)2.46085783
46Polyuria (HP:0000103)2.41366734
47Hyperphosphatemia (HP:0002905)2.40486116
48Abolished electroretinogram (ERG) (HP:0000550)2.38535358
49Recurrent corneal erosions (HP:0000495)2.38137609
50Abnormality of renal resorption (HP:0011038)2.36436177
51Male infertility (HP:0003251)2.35832237
52Methylmalonic aciduria (HP:0012120)2.33439763
53Abnormality of DNA repair (HP:0003254)2.32689914
54Acute encephalopathy (HP:0006846)2.31301437
55Severe combined immunodeficiency (HP:0004430)2.29372738
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.28542019
57Muscle fiber atrophy (HP:0100295)2.28348237
58Type I transferrin isoform profile (HP:0003642)2.24328185
59Progressive macrocephaly (HP:0004481)2.18551816
60Abnormal hemoglobin (HP:0011902)2.14218108
61Reduced antithrombin III activity (HP:0001976)2.13697587
62Abnormality of vitamin B metabolism (HP:0004340)2.12868253
63Ketosis (HP:0001946)2.11172659
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10281013
65Abnormal mitochondria in muscle tissue (HP:0008316)2.09624110
66Constricted visual fields (HP:0001133)2.09600691
67True hermaphroditism (HP:0010459)2.06520072
68Pancreatic fibrosis (HP:0100732)2.04891302
69IgG deficiency (HP:0004315)2.03616420
70Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00355450
71Neonatal respiratory distress (HP:0002643)2.00336388
72Asplenia (HP:0001746)1.99583402
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98236450
74Abnormal protein N-linked glycosylation (HP:0012347)1.98236450
75Abnormal protein glycosylation (HP:0012346)1.98236450
76Abnormal glycosylation (HP:0012345)1.98236450
77Hypoglycemic seizures (HP:0002173)1.96852843
78Abnormal urine output (HP:0012590)1.96289039
79Type I diabetes mellitus (HP:0100651)1.96011027
80Nephronophthisis (HP:0000090)1.94256449
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.90729666
82Neutropenia (HP:0001875)1.89562930
83Thyroiditis (HP:0100646)1.87805771
84Autoimmune thrombocytopenia (HP:0001973)1.86641103
85Abnormality of midbrain morphology (HP:0002418)1.85879782
86Molar tooth sign on MRI (HP:0002419)1.85879782
87Exertional dyspnea (HP:0002875)1.85447197
88Increased serum lactate (HP:0002151)1.85080782
89Acute lymphatic leukemia (HP:0006721)1.84509518
90Abnormality of the phalanges of the 5th finger (HP:0004213)1.83455121
91Focal motor seizures (HP:0011153)1.82799655
92Medial flaring of the eyebrow (HP:0010747)1.81386319
93Hepatic necrosis (HP:0002605)1.79385335
94Aplastic anemia (HP:0001915)1.79007055
95Thyroid-stimulating hormone excess (HP:0002925)1.76716479
96Congenital hepatic fibrosis (HP:0002612)1.76377180
97Genetic anticipation (HP:0003743)1.76111416
98Delayed CNS myelination (HP:0002188)1.75736627
99Hepatocellular necrosis (HP:0001404)1.74085216
100Lethargy (HP:0001254)1.73384324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.41271380
2TAOK33.86662079
3PBK3.16811038
4FLT32.87443488
5ZAK2.79906373
6BCKDK2.64393208
7TXK2.53681739
8CDK192.49369362
9MST42.45122606
10KIT2.31861168
11PRKG22.27672317
12WNK42.14569326
13MAP3K122.13040923
14GRK12.12217141
15AKT32.08586062
16ADRBK22.03741142
17MAP4K12.01364264
18PASK1.89526068
19STK161.80829655
20RPS6KB21.77620147
21PIK3CG1.73345570
22EIF2AK31.68980077
23FRK1.59384563
24VRK21.56036400
25TEC1.51843953
26ZAP701.45967805
27DYRK21.41654147
28NUAK11.40339776
29MAP2K61.38715153
30TLK11.26850002
31IKBKE1.20096443
32MAP3K111.19153198
33STK391.18964181
34ADRBK11.16462878
35ITK1.12823584
36OXSR11.08577635
37GRK61.01997434
38CSF1R0.97749432
39VRK10.97628384
40PLK40.95835368
41IKBKB0.93510719
42NME20.90726684
43MAP3K60.88743125
44PIK3CA0.87938587
45PRKCQ0.87321167
46SYK0.86810415
47MAP3K50.78512467
48KDR0.78013943
49MKNK10.74687359
50LCK0.72784278
51PRKCH0.72178020
52INSRR0.68977006
53BTK0.64347043
54MKNK20.61034041
55NEK10.60862196
56CCNB10.59228915
57MAP2K40.58409686
58TIE10.57673576
59PDK20.57670483
60TNIK0.56272100
61OBSCN0.55083280
62BLK0.54673001
63FES0.53933313
64GRK70.53896629
65BMPR20.53312566
66PRKCE0.53120580
67EIF2AK10.52223126
68MAP2K30.52073284
69MAPK130.51651598
70PHKG20.48855610
71PHKG10.48855610
72LYN0.48800720
73PLK10.47384709
74MAPKAPK50.47240168
75LIMK10.46881177
76CSNK1G30.46705267
77CSNK2A20.46593967
78TGFBR10.46048000
79JAK30.43518197
80WNK30.43395035
81PINK10.42135316
82PRKACA0.40797181
83CSNK1A1L0.39421030
84RPS6KB10.39270952
85AURKA0.37791613
86TAOK20.37753855
87MAPKAPK30.36360943
88CSNK1G10.35957693
89RPS6KA50.34710439
90CSK0.34403280
91DAPK30.33281948
92PLK30.33261045
93CHEK20.32312676
94NME10.31978574
95CDK80.30244154
96PRKCA0.29720710
97RPS6KA60.29227279
98TAF10.29172257
99TRPM70.28788829
100CSNK2A10.28638244

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.22568147
2Asthma_Homo sapiens_hsa053102.95366638
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.88689850
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87114148
5Allograft rejection_Homo sapiens_hsa053302.77520454
6Vitamin B6 metabolism_Homo sapiens_hsa007502.71464097
7Phototransduction_Homo sapiens_hsa047442.62351232
8Proteasome_Homo sapiens_hsa030502.50344631
9Autoimmune thyroid disease_Homo sapiens_hsa053202.47332815
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00453362
11Graft-versus-host disease_Homo sapiens_hsa053322.00079065
12Primary immunodeficiency_Homo sapiens_hsa053401.96402493
13Oxidative phosphorylation_Homo sapiens_hsa001901.89648081
14RNA polymerase_Homo sapiens_hsa030201.84447319
15Linoleic acid metabolism_Homo sapiens_hsa005911.81944728
16Protein export_Homo sapiens_hsa030601.79996164
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77774427
18RNA degradation_Homo sapiens_hsa030181.69562102
19Type I diabetes mellitus_Homo sapiens_hsa049401.64680271
20Parkinsons disease_Homo sapiens_hsa050121.61593193
21Butanoate metabolism_Homo sapiens_hsa006501.49965594
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49672516
23Olfactory transduction_Homo sapiens_hsa047401.43290335
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34824052
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30830858
26RNA transport_Homo sapiens_hsa030131.29787202
27Sulfur metabolism_Homo sapiens_hsa009201.25314467
28One carbon pool by folate_Homo sapiens_hsa006701.23855635
29Nucleotide excision repair_Homo sapiens_hsa034201.21528837
30Homologous recombination_Homo sapiens_hsa034401.19183037
31Cardiac muscle contraction_Homo sapiens_hsa042601.15722071
32Basal transcription factors_Homo sapiens_hsa030221.15426072
33Hematopoietic cell lineage_Homo sapiens_hsa046401.13303664
34Retinol metabolism_Homo sapiens_hsa008301.10733516
35Propanoate metabolism_Homo sapiens_hsa006401.08696461
36Alzheimers disease_Homo sapiens_hsa050101.06930973
37Caffeine metabolism_Homo sapiens_hsa002321.00881447
38Peroxisome_Homo sapiens_hsa041460.99994846
39Purine metabolism_Homo sapiens_hsa002300.96374938
40Pyrimidine metabolism_Homo sapiens_hsa002400.94913774
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94435871
42Fanconi anemia pathway_Homo sapiens_hsa034600.94225305
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92380789
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92017274
45Nicotine addiction_Homo sapiens_hsa050330.91685277
46Mismatch repair_Homo sapiens_hsa034300.91114786
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91055467
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.87525410
49Huntingtons disease_Homo sapiens_hsa050160.87362455
50Antigen processing and presentation_Homo sapiens_hsa046120.86575826
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86498019
52Chemical carcinogenesis_Homo sapiens_hsa052040.86278081
53Arachidonic acid metabolism_Homo sapiens_hsa005900.85416924
54Salivary secretion_Homo sapiens_hsa049700.84519794
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84372285
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.83094559
57Nitrogen metabolism_Homo sapiens_hsa009100.82578128
58Taste transduction_Homo sapiens_hsa047420.72500466
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71807947
60Rheumatoid arthritis_Homo sapiens_hsa053230.71793871
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71457741
62Fat digestion and absorption_Homo sapiens_hsa049750.71419938
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71257228
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70187305
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69715485
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69278412
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68093011
68T cell receptor signaling pathway_Homo sapiens_hsa046600.67200106
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65883632
70African trypanosomiasis_Homo sapiens_hsa051430.65503840
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.65081020
72Ether lipid metabolism_Homo sapiens_hsa005650.64209774
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59503091
74Dorso-ventral axis formation_Homo sapiens_hsa043200.58664829
75Renin secretion_Homo sapiens_hsa049240.57509666
76N-Glycan biosynthesis_Homo sapiens_hsa005100.54127856
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52455643
78Vitamin digestion and absorption_Homo sapiens_hsa049770.52247531
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.50985149
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.50772328
81Measles_Homo sapiens_hsa051620.49644630
82Base excision repair_Homo sapiens_hsa034100.48413484
83Metabolic pathways_Homo sapiens_hsa011000.46111977
84Long-term depression_Homo sapiens_hsa047300.45446413
85Regulation of autophagy_Homo sapiens_hsa041400.43841610
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41657620
87Systemic lupus erythematosus_Homo sapiens_hsa053220.41536677
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40562235
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39950975
90Selenocompound metabolism_Homo sapiens_hsa004500.39880567
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.39718778
92Spliceosome_Homo sapiens_hsa030400.37447196
93Circadian entrainment_Homo sapiens_hsa047130.37263394
94Renin-angiotensin system_Homo sapiens_hsa046140.36737915
95Starch and sucrose metabolism_Homo sapiens_hsa005000.36491754
96Tryptophan metabolism_Homo sapiens_hsa003800.34378334
97Serotonergic synapse_Homo sapiens_hsa047260.34091551
98Pancreatic secretion_Homo sapiens_hsa049720.32725072
99Glutathione metabolism_Homo sapiens_hsa004800.31949674
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30342709

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