TPT1P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.22618423
2ribosomal small subunit assembly (GO:0000028)6.13799630
3ribosomal small subunit biogenesis (GO:0042274)6.07002299
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.82805355
5cytidine deamination (GO:0009972)5.77903252
6cytidine metabolic process (GO:0046087)5.77903252
7cytidine catabolic process (GO:0006216)5.77903252
8viral transcription (GO:0019083)5.04091490
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.98105877
10translational termination (GO:0006415)4.79772316
11regulation of regulatory T cell differentiation (GO:0045589)4.30379273
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30288237
13translational elongation (GO:0006414)4.30198063
14protein targeting to ER (GO:0045047)4.26166504
15regulation of activation of Janus kinase activity (GO:0010533)4.22159408
16positive regulation of defense response to virus by host (GO:0002230)4.21401521
17cotranslational protein targeting to membrane (GO:0006613)4.20506645
18ncRNA 3-end processing (GO:0043628)4.13332870
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09233268
20protein localization to endoplasmic reticulum (GO:0070972)4.04607179
21ribosomal large subunit biogenesis (GO:0042273)3.99322876
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96381822
23ATP synthesis coupled proton transport (GO:0015986)3.96381822
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96222073
25leukocyte aggregation (GO:0070486)3.86008509
26positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79492757
27negative regulation of mast cell activation (GO:0033004)3.74349208
28viral life cycle (GO:0019058)3.69759166
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62371374
30maturation of SSU-rRNA (GO:0030490)3.60853657
31negative regulation by host of viral transcription (GO:0043922)3.55590679
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50116775
33cellular protein complex disassembly (GO:0043624)3.47083584
34regulation of B cell receptor signaling pathway (GO:0050855)3.46627407
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.39182305
36chaperone-mediated protein transport (GO:0072321)3.37757456
37positive regulation of natural killer cell mediated immunity (GO:0002717)3.33862311
38translational initiation (GO:0006413)3.32356974
39regulation of isotype switching to IgG isotypes (GO:0048302)3.28886617
40pseudouridine synthesis (GO:0001522)3.27420868
41regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.27118559
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22513453
43electron transport chain (GO:0022900)3.15935565
44behavioral response to nicotine (GO:0035095)3.15521247
45respiratory electron transport chain (GO:0022904)3.15405405
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.14065966
47termination of RNA polymerase III transcription (GO:0006386)3.14065966
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.10070492
49translation (GO:0006412)3.09663222
50protein neddylation (GO:0045116)3.08198671
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02051234
52regulation of natural killer cell mediated immunity (GO:0002715)3.02051234
53platelet dense granule organization (GO:0060155)3.01842944
54regulation of T cell mediated cytotoxicity (GO:0001914)3.00182256
55activation of MAPKKK activity (GO:0000185)2.98793402
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98182950
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98182950
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97709774
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.97709774
60NADH dehydrogenase complex assembly (GO:0010257)2.97709774
61establishment of protein localization to mitochondrial membrane (GO:0090151)2.96559962
62water-soluble vitamin biosynthetic process (GO:0042364)2.93932985
63positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.92120061
64regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90859373
65protein complex biogenesis (GO:0070271)2.90380186
66regulation of T cell receptor signaling pathway (GO:0050856)2.88440510
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86514485
68regulation of chronic inflammatory response (GO:0002676)2.85854560
69ribonucleoprotein complex biogenesis (GO:0022613)2.85604237
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80990657
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80908571
72cellular component biogenesis (GO:0044085)2.80296986
73positive regulation of cell killing (GO:0031343)2.77435545
74cellular response to interleukin-15 (GO:0071350)2.75940503
75positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.74558626
76rRNA metabolic process (GO:0016072)2.73604500
77regulation of immunoglobulin secretion (GO:0051023)2.73417349
78protein targeting to membrane (GO:0006612)2.71472232
79protein complex disassembly (GO:0043241)2.70607591
80positive regulation of interleukin-17 production (GO:0032740)2.67886462
81negative regulation of phagocytosis (GO:0050765)2.67458476
82nuclear-transcribed mRNA catabolic process (GO:0000956)2.64079866
83cytolysis (GO:0019835)2.62243932
84regulation of cell killing (GO:0031341)2.61931998
85positive thymic T cell selection (GO:0045059)2.59354366
86intracellular protein transmembrane import (GO:0044743)2.59118455
87macromolecular complex disassembly (GO:0032984)2.57416149
88negative regulation of T cell apoptotic process (GO:0070233)2.56151351
89pyrimidine nucleoside catabolic process (GO:0046135)2.55394673
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54642455
91positive T cell selection (GO:0043368)2.54189053
92rRNA processing (GO:0006364)2.53945932
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.52805902
94interferon-gamma production (GO:0032609)2.52734439
95mast cell activation (GO:0045576)2.52192107
96mitochondrial respiratory chain complex assembly (GO:0033108)2.50768639
97metallo-sulfur cluster assembly (GO:0031163)2.49706633
98iron-sulfur cluster assembly (GO:0016226)2.49706633
99regulation of gamma-delta T cell differentiation (GO:0045586)2.46858938
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45901348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.76022950
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31108026
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.61163252
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.25873313
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18809700
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00320294
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79086718
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.73129586
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59019299
10VDR_22108803_ChIP-Seq_LS180_Human2.58750772
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.42760214
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.35327431
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.18968892
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18087175
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02370180
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98045080
17VDR_23849224_ChIP-Seq_CD4+_Human1.84744480
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84369430
19RUNX_20019798_ChIP-Seq_JUKART_Human1.74747260
20IGF1R_20145208_ChIP-Seq_DFB_Human1.74251772
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73945229
22TP53_22573176_ChIP-Seq_HFKS_Human1.73349336
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.69241195
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64803832
25FOXP3_21729870_ChIP-Seq_TREG_Human1.62307878
26FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59739134
27FOXA1_25329375_ChIP-Seq_VCAP_Human1.59739134
28ZNF274_21170338_ChIP-Seq_K562_Hela1.59683843
29MYB_26560356_Chip-Seq_TH2_Human1.57701773
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56274778
31MYC_18940864_ChIP-ChIP_HL60_Human1.55501087
32GATA3_26560356_Chip-Seq_TH2_Human1.51916561
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51680634
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51375291
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.47475530
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45047094
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42524158
38NCOR_22424771_ChIP-Seq_293T_Human1.42443448
39NANOG_20526341_ChIP-Seq_ESCs_Human1.42395081
40EWS_26573619_Chip-Seq_HEK293_Human1.38254676
41AR_20517297_ChIP-Seq_VCAP_Human1.37507834
42SOX2_19829295_ChIP-Seq_ESCs_Human1.36635407
43NANOG_19829295_ChIP-Seq_ESCs_Human1.36635407
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35116082
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34413374
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.34172400
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.32690760
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31974471
49ELK1_19687146_ChIP-ChIP_HELA_Human1.29971487
50GATA3_27048872_Chip-Seq_THYMUS_Human1.29638729
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29479735
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26497541
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25780466
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25424444
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24365494
56TAF2_19829295_ChIP-Seq_ESCs_Human1.24047779
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22213387
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21916354
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19934299
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19881942
61STAT1_20625510_ChIP-Seq_HELA_Human1.19771549
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.19556689
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15257943
64FUS_26573619_Chip-Seq_HEK293_Human1.13551244
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11301367
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10222390
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09612590
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09491725
69IRF1_19129219_ChIP-ChIP_H3396_Human1.09334791
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09062684
71MYC_19829295_ChIP-Seq_ESCs_Human1.08908067
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08878064
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08295369
74ERA_21632823_ChIP-Seq_H3396_Human1.07627220
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07254129
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05654741
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04974517
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04851081
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04493316
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04374711
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04203347
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.04161096
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.00618651
84CBP_20019798_ChIP-Seq_JUKART_Human0.99365695
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99365695
86EZH2_22144423_ChIP-Seq_EOC_Human0.98859231
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98629942
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96874957
89ERG_20517297_ChIP-Seq_VCAP_Human0.96839114
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96515408
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.96323405
92BCL6_27268052_Chip-Seq_Bcells_Human0.96221694
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96065876
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96056810
95P53_21459846_ChIP-Seq_SAOS-2_Human0.95546293
96ER_23166858_ChIP-Seq_MCF-7_Human0.94742316
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.94647719
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.92076766
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92073716
100CTCF_20526341_ChIP-Seq_ESCs_Human0.91979012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.10466823
2MP0009379_abnormal_foot_pigmentation3.99948218
3MP0003646_muscle_fatigue2.97991767
4MP0004147_increased_porphyrin_level2.90213949
5MP0009785_altered_susceptibility_to2.57697160
6MP0001835_abnormal_antigen_presentation2.55965442
7MP0006082_CNS_inflammation2.41021240
8MP0001873_stomach_inflammation2.31270426
9MP0009333_abnormal_splenocyte_physiolog2.18303107
10MP0005075_abnormal_melanosome_morpholog2.08004570
11MP0001800_abnormal_humoral_immune2.02646535
12MP0003763_abnormal_thymus_physiology2.01757640
13MP0005623_abnormal_meninges_morphology1.98882626
14MP0002148_abnormal_hypersensitivity_rea1.90969785
15MP0006292_abnormal_olfactory_placode1.85596021
16MP0002837_dystrophic_cardiac_calcinosis1.81044493
17MP0000372_irregular_coat_pigmentation1.80530811
18MP0001188_hyperpigmentation1.78381017
19MP0005000_abnormal_immune_tolerance1.77285214
20MP0003786_premature_aging1.76297015
21MP0002163_abnormal_gland_morphology1.71955376
22MP0005174_abnormal_tail_pigmentation1.67848193
23MP0002876_abnormal_thyroid_physiology1.66719534
24MP0008872_abnormal_physiological_respon1.65624241
25MP0008875_abnormal_xenobiotic_pharmacok1.60592456
26MP0005645_abnormal_hypothalamus_physiol1.58994533
27MP0004885_abnormal_endolymph1.58685160
28MP0005377_hearing/vestibular/ear_phenot1.56538596
29MP0003878_abnormal_ear_physiology1.56538596
30MP0004145_abnormal_muscle_electrophysio1.53665542
31MP0002723_abnormal_immune_serum1.53175982
32MP0001790_abnormal_immune_system1.49367226
33MP0005387_immune_system_phenotype1.49367226
34MP0002420_abnormal_adaptive_immunity1.48715304
35MP0005551_abnormal_eye_electrophysiolog1.47164137
36MP0005646_abnormal_pituitary_gland1.46253096
37MP0001819_abnormal_immune_cell1.45801126
38MP0005084_abnormal_gallbladder_morpholo1.43138801
39MP0000685_abnormal_immune_system1.41660494
40MP0009384_cardiac_valve_regurgitation1.39768773
41MP0002095_abnormal_skin_pigmentation1.39645946
42MP0005025_abnormal_response_to1.38888077
43MP0002138_abnormal_hepatobiliary_system1.37679040
44MP0002160_abnormal_reproductive_system1.34085704
45MP0005389_reproductive_system_phenotype1.34057283
46MP0002736_abnormal_nociception_after1.31566460
47MP0002933_joint_inflammation1.30535299
48MP0008877_abnormal_DNA_methylation1.29844346
49MP0002452_abnormal_antigen_presenting1.26463131
50MP0000013_abnormal_adipose_tissue1.26444009
51MP0001986_abnormal_taste_sensitivity1.25894588
52MP0004142_abnormal_muscle_tone1.24849238
53MP0001968_abnormal_touch/_nociception1.23606961
54MP0009764_decreased_sensitivity_to1.23251644
55MP0003879_abnormal_hair_cell1.22683284
56MP0005379_endocrine/exocrine_gland_phen1.22647805
57MP0002166_altered_tumor_susceptibility1.21883783
58MP0003866_abnormal_defecation1.21482105
59MP0003806_abnormal_nucleotide_metabolis1.20155931
60MP0000015_abnormal_ear_pigmentation1.18597359
61MP0002277_abnormal_respiratory_mucosa1.18000983
62MP0002398_abnormal_bone_marrow1.15853848
63MP0001485_abnormal_pinna_reflex1.14924898
64MP0000716_abnormal_immune_system1.12973192
65MP0000689_abnormal_spleen_morphology1.12629901
66MP0010155_abnormal_intestine_physiology1.10307329
67MP0002006_tumorigenesis1.08934387
68MP0003195_calcinosis1.05327843
69MP0009765_abnormal_xenobiotic_induced1.03660646
70MP0003724_increased_susceptibility_to1.00689077
71MP0000703_abnormal_thymus_morphology1.00430217
72MP0002722_abnormal_immune_system0.98765788
73MP0002102_abnormal_ear_morphology0.97988084
74MP0002405_respiratory_system_inflammati0.97898183
75MP0001919_abnormal_reproductive_system0.97448232
76MP0002938_white_spotting0.97241122
77MP0001727_abnormal_embryo_implantation0.97069167
78MP0006072_abnormal_retinal_apoptosis0.95982558
79MP0004947_skin_inflammation0.95898178
80MP0001905_abnormal_dopamine_level0.95465651
81MP0002638_abnormal_pupillary_reflex0.92462655
82MP0002429_abnormal_blood_cell0.91712790
83MP0008469_abnormal_protein_level0.88776372
84MP0002272_abnormal_nervous_system0.84928874
85MP0001501_abnormal_sleep_pattern0.82944465
86MP0004742_abnormal_vestibular_system0.82849023
87MP0001845_abnormal_inflammatory_respons0.80046529
88MP0004510_myositis0.79713125
89MP0005410_abnormal_fertilization0.78815642
90MP0001663_abnormal_digestive_system0.78508741
91MP0010386_abnormal_urinary_bladder0.74611644
92MP0005083_abnormal_biliary_tract0.73144418
93MP0003567_abnormal_fetal_cardiomyocyte0.73076152
94MP0008775_abnormal_heart_ventricle0.69766824
95MP0005464_abnormal_platelet_physiology0.69342143
96MP0004036_abnormal_muscle_relaxation0.68264883
97MP0008995_early_reproductive_senescence0.66127665
98MP0002419_abnormal_innate_immunity0.65813113
99MP0002234_abnormal_pharynx_morphology0.65288621
100MP0005636_abnormal_mineral_homeostasis0.64844219

Predicted human phenotypes

RankGene SetZ-score
1Decreased electroretinogram (ERG) amplitude (HP:0000654)5.87197563
2Type II lissencephaly (HP:0007260)5.15944020
3Cerebellar dysplasia (HP:0007033)4.97155188
4IgG deficiency (HP:0004315)4.32993964
5Hypoplasia of the pons (HP:0012110)4.08750998
6Retinal atrophy (HP:0001105)4.03528490
7Abnormality of the pons (HP:0007361)3.85130326
8Constricted visual fields (HP:0001133)3.58926377
9Abolished electroretinogram (ERG) (HP:0000550)3.58166189
10Severe combined immunodeficiency (HP:0004430)3.52453172
11Retinal dysplasia (HP:0007973)3.50616393
12Acute necrotizing encephalopathy (HP:0006965)3.49881629
13Increased IgM level (HP:0003496)3.49832347
143-Methylglutaconic aciduria (HP:0003535)3.46723841
15Abnormality of macular pigmentation (HP:0008002)3.46167073
16Congenital stationary night blindness (HP:0007642)3.25225189
17Abnormality of eosinophils (HP:0001879)3.18725350
18Abnormality of B cell number (HP:0010975)3.18126952
19T lymphocytopenia (HP:0005403)3.15108538
20Attenuation of retinal blood vessels (HP:0007843)3.15092063
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12227135
22Abnormality of T cell number (HP:0011839)3.10555085
23Acute encephalopathy (HP:0006846)3.09232738
24Abnormality of midbrain morphology (HP:0002418)3.07607544
25Molar tooth sign on MRI (HP:0002419)3.07607544
26Mitochondrial inheritance (HP:0001427)3.02368205
27Abnormal mitochondria in muscle tissue (HP:0008316)3.01454659
28Thyroiditis (HP:0100646)2.98879691
29Eosinophilia (HP:0001880)2.89797955
30Elevated erythrocyte sedimentation rate (HP:0003565)2.85489323
31Progressive macrocephaly (HP:0004481)2.82810347
32B lymphocytopenia (HP:0010976)2.81350921
33Optic disc pallor (HP:0000543)2.81046683
34Cone-rod dystrophy (HP:0000548)2.80341804
35Aplasia/Hypoplasia affecting the retina (HP:0008061)2.79932323
36Pancreatic cysts (HP:0001737)2.74877948
37Increased CSF lactate (HP:0002490)2.69870552
38Abnormality of the renal cortex (HP:0011035)2.69281798
39Aplastic anemia (HP:0001915)2.68403144
40Methylmalonic acidemia (HP:0002912)2.68146991
41Stomatitis (HP:0010280)2.65202429
42Combined immunodeficiency (HP:0005387)2.60718735
43Hyperglycinemia (HP:0002154)2.58764386
44Abnormal rod and cone electroretinograms (HP:0008323)2.56927385
45Nephronophthisis (HP:0000090)2.51117187
46Severe visual impairment (HP:0001141)2.51000557
47Congenital, generalized hypertrichosis (HP:0004540)2.48451847
48Buphthalmos (HP:0000557)2.46160908
49True hermaphroditism (HP:0010459)2.45813648
50Pallor (HP:0000980)2.44104499
51Abnormality of cells of the erythroid lineage (HP:0012130)2.40608347
52Renal cortical cysts (HP:0000803)2.36205720
53Hypoproteinemia (HP:0003075)2.35187787
54Abnormality of T cells (HP:0002843)2.32984075
55Pancreatic fibrosis (HP:0100732)2.31707926
56Increased hepatocellular lipid droplets (HP:0006565)2.30066111
57Fatigue (HP:0012378)2.26978454
58Lipid accumulation in hepatocytes (HP:0006561)2.26554008
59Mesangial abnormality (HP:0001966)2.26436368
60Abnormality of DNA repair (HP:0003254)2.24613481
61Severe muscular hypotonia (HP:0006829)2.20459807
62Autoimmune hemolytic anemia (HP:0001890)2.19993569
63Macrocytic anemia (HP:0001972)2.18948309
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10201131
65Hepatocellular necrosis (HP:0001404)2.10126447
66Abnormal number of erythroid precursors (HP:0012131)2.07617977
67Leukocytosis (HP:0001974)2.06441276
68Cerebral edema (HP:0002181)2.05244094
69Methylmalonic aciduria (HP:0012120)2.04961848
70Increased intramyocellular lipid droplets (HP:0012240)2.04824229
71Panhypogammaglobulinemia (HP:0003139)2.01555954
72Granulocytopenia (HP:0001913)1.99896098
73Type 2 muscle fiber atrophy (HP:0003554)1.99455704
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.98362486
75Abnormality of the renal medulla (HP:0100957)1.97744457
76Asplenia (HP:0001746)1.95856932
77Hepatic necrosis (HP:0002605)1.93376360
78Polydipsia (HP:0001959)1.92863859
79Abnormal drinking behavior (HP:0030082)1.92863859
80Encephalitis (HP:0002383)1.92244556
81Renal Fanconi syndrome (HP:0001994)1.92200093
82Pancytopenia (HP:0001876)1.89450803
83Conical tooth (HP:0000698)1.88685139
84Reticulocytopenia (HP:0001896)1.88421425
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87398092
86Erythroderma (HP:0001019)1.86571255
87Lethargy (HP:0001254)1.82583019
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79846960
89Stenosis of the external auditory canal (HP:0000402)1.76388504
90Increased muscle lipid content (HP:0009058)1.74289969
91Bile duct proliferation (HP:0001408)1.71536949
92Abnormal biliary tract physiology (HP:0012439)1.71536949
93Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70403309
94Dicarboxylic aciduria (HP:0003215)1.70403309
95IgM deficiency (HP:0002850)1.69494689
96Volvulus (HP:0002580)1.63112978
97Exertional dyspnea (HP:0002875)1.63036674
98Striae distensae (HP:0001065)1.62079816
99Chronic hepatic failure (HP:0100626)1.61041335
100Polyuria (HP:0000103)1.60459268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.97330002
2KIT3.48517841
3MAP4K13.17732711
4KDR3.11244109
5ADRBK22.93630930
6ZAK2.57411099
7MARK32.52831394
8TEC2.43406746
9TAOK32.38941506
10BCKDK2.27803683
11CDK192.27311827
12GRK12.06563129
13STK102.02434649
14TLK11.94297097
15MAP4K21.91590588
16FES1.90744543
17MST41.84747688
18IKBKB1.80875104
19WNK41.75730630
20NUAK11.73977740
21ITK1.73274454
22VRK21.64588371
23STK161.57119755
24TIE11.56746527
25PIK3CA1.53805945
26FRK1.51343140
27PINK11.50132378
28SYK1.44675571
29LIMK11.44188228
30CAMKK21.38411127
31PIM11.36245199
32TESK21.35687384
33PRKCQ1.23051964
34TRPM71.12327440
35MATK1.11967332
36VRK11.10670128
37INSRR1.08108096
38OXSR11.04296119
39STK391.03286582
40LCK0.95927229
41MAP3K140.92947940
42PIK3CG0.91806436
43MAP3K120.91418862
44OBSCN0.91186524
45BTK0.89788983
46MAP2K60.89368336
47IKBKE0.86909109
48NME20.86288782
49DYRK20.85186440
50ADRBK10.84572648
51RPS6KA50.83663474
52CSK0.82951754
53LYN0.81297038
54MAP3K110.73943312
55PRKCH0.72335365
56ZAP700.68340002
57NLK0.66984049
58BMPR1B0.64525134
59MAP2K20.62570949
60STK110.58918910
61ILK0.55434603
62PASK0.53876520
63PTK2B0.53570342
64NME10.50878098
65EIF2AK30.50536047
66PHKG10.47315559
67PHKG20.47315559
68CDK30.46773993
69RPS6KB20.45702330
70PRKCE0.45677329
71MYLK0.45239694
72GRK70.44433586
73TGFBR10.44212535
74IGF1R0.43434174
75PRKACA0.43069728
76CSNK2A20.42713240
77GRK60.41473963
78RPS6KA60.40885902
79ABL20.39856989
80CDK80.39808195
81BMPR20.37592332
82WNK30.37291506
83PRKCA0.36639834
84INSR0.34510228
85CSNK2A10.34154128
86RIPK40.33671220
87JAK30.33551321
88PRKCD0.33062669
89PRKCG0.28830585
90BRSK20.28537387
91PLK40.27235954
92MUSK0.27205296
93RPS6KC10.26370684
94RPS6KL10.26370684
95SRPK10.26352546
96MAPK130.25903866
97HCK0.25328537
98CAMKK10.25122325
99CSNK1D0.24472092
100CSNK1A10.22000655

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.56056501
2Primary immunodeficiency_Homo sapiens_hsa053403.64995156
3Oxidative phosphorylation_Homo sapiens_hsa001903.55390047
4Proteasome_Homo sapiens_hsa030502.98217157
5Parkinsons disease_Homo sapiens_hsa050122.89076533
6Allograft rejection_Homo sapiens_hsa053302.79848326
7Graft-versus-host disease_Homo sapiens_hsa053322.69069577
8Autoimmune thyroid disease_Homo sapiens_hsa053202.45584496
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38456846
10RNA polymerase_Homo sapiens_hsa030202.27099704
11Type I diabetes mellitus_Homo sapiens_hsa049402.18920007
12Asthma_Homo sapiens_hsa053101.95020794
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94057046
14Protein export_Homo sapiens_hsa030601.92838502
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91832164
16Alzheimers disease_Homo sapiens_hsa050101.88476429
17Hematopoietic cell lineage_Homo sapiens_hsa046401.87220476
18Huntingtons disease_Homo sapiens_hsa050161.82761304
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.78919698
20Antigen processing and presentation_Homo sapiens_hsa046121.74888967
21Linoleic acid metabolism_Homo sapiens_hsa005911.62190837
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60895585
23Sulfur metabolism_Homo sapiens_hsa009201.51054142
24Phototransduction_Homo sapiens_hsa047441.48626843
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46535261
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44677441
27Cardiac muscle contraction_Homo sapiens_hsa042601.44210455
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40457560
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.38996104
30RNA degradation_Homo sapiens_hsa030181.36154905
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30450447
32Caffeine metabolism_Homo sapiens_hsa002321.26766147
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25013175
34T cell receptor signaling pathway_Homo sapiens_hsa046601.20925201
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17643831
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15982939
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12623254
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12591431
39Rheumatoid arthritis_Homo sapiens_hsa053231.11227936
40Peroxisome_Homo sapiens_hsa041461.10126870
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05545504
42Basal transcription factors_Homo sapiens_hsa030221.03265723
43Nitrogen metabolism_Homo sapiens_hsa009101.01677496
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01347466
45Arachidonic acid metabolism_Homo sapiens_hsa005900.98087083
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.96708130
47Pyrimidine metabolism_Homo sapiens_hsa002400.93652598
48Homologous recombination_Homo sapiens_hsa034400.92856529
49Olfactory transduction_Homo sapiens_hsa047400.91933490
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86466717
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83804044
52Measles_Homo sapiens_hsa051620.82782275
53Tryptophan metabolism_Homo sapiens_hsa003800.81719069
54Malaria_Homo sapiens_hsa051440.80976925
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.80077826
56Retinol metabolism_Homo sapiens_hsa008300.76316642
57Butanoate metabolism_Homo sapiens_hsa006500.76095546
58Regulation of autophagy_Homo sapiens_hsa041400.69564474
59Chemical carcinogenesis_Homo sapiens_hsa052040.69490045
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69157725
61Nucleotide excision repair_Homo sapiens_hsa034200.68143341
62Purine metabolism_Homo sapiens_hsa002300.66338384
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66131838
64Propanoate metabolism_Homo sapiens_hsa006400.60483440
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60130081
66Leishmaniasis_Homo sapiens_hsa051400.57537887
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56637863
68Sulfur relay system_Homo sapiens_hsa041220.55713582
69Nicotine addiction_Homo sapiens_hsa050330.55110539
70Fat digestion and absorption_Homo sapiens_hsa049750.54881691
71Ether lipid metabolism_Homo sapiens_hsa005650.53130865
72African trypanosomiasis_Homo sapiens_hsa051430.52814067
73Fanconi anemia pathway_Homo sapiens_hsa034600.52785060
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50806181
75Metabolic pathways_Homo sapiens_hsa011000.48604517
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48332475
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47127512
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.43531857
79One carbon pool by folate_Homo sapiens_hsa006700.43178108
80Taste transduction_Homo sapiens_hsa047420.42878806
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.42343413
82Mineral absorption_Homo sapiens_hsa049780.37388231
83Salivary secretion_Homo sapiens_hsa049700.33573090
84Systemic lupus erythematosus_Homo sapiens_hsa053220.33449172
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32913575
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32764541
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32041450
88Viral myocarditis_Homo sapiens_hsa054160.30657378
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.26795243
90Mismatch repair_Homo sapiens_hsa034300.25009673
91Spliceosome_Homo sapiens_hsa030400.24419838
92RNA transport_Homo sapiens_hsa030130.22035246
93Herpes simplex infection_Homo sapiens_hsa051680.21085558
94Serotonergic synapse_Homo sapiens_hsa047260.20878040
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.20682386
96Epstein-Barr virus infection_Homo sapiens_hsa051690.20669894
97Staphylococcus aureus infection_Homo sapiens_hsa051500.20047219
98Vitamin digestion and absorption_Homo sapiens_hsa049770.19084893
99Glutathione metabolism_Homo sapiens_hsa004800.18721505
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17976884

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