TPTE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.80617374
2cell wall macromolecule metabolic process (GO:0044036)9.80617374
3regulation of phosphoprotein phosphatase activity (GO:0043666)9.25124884
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.09083409
5fusion of sperm to egg plasma membrane (GO:0007342)9.06208247
6positive regulation of catecholamine secretion (GO:0033605)9.00496319
7chromosome organization involved in meiosis (GO:0070192)8.31426067
8multicellular organism reproduction (GO:0032504)8.09478653
9cilium or flagellum-dependent cell motility (GO:0001539)7.07553705
10meiotic nuclear division (GO:0007126)6.85107707
11regulation of oxidative stress-induced neuron death (GO:1903203)6.80005287
12plasma membrane fusion (GO:0045026)6.78210457
13acrosome assembly (GO:0001675)6.31061343
14relaxation of smooth muscle (GO:0044557)6.25517071
15reproduction (GO:0000003)6.23307959
16regulation of activation of Janus kinase activity (GO:0010533)6.04769172
17regulation of oxidative phosphorylation (GO:0002082)6.02438195
18protein-DNA complex disassembly (GO:0032986)6.00940528
19nucleosome disassembly (GO:0006337)6.00940528
20polyamine biosynthetic process (GO:0006596)5.85234781
21potassium ion export (GO:0071435)5.85189395
22DNA synthesis involved in DNA repair (GO:0000731)5.83173956
23sperm-egg recognition (GO:0035036)5.60821387
24piRNA metabolic process (GO:0034587)5.49012750
25purine ribonucleotide transport (GO:0015868)5.42395307
26germ cell development (GO:0007281)5.38777755
27oogenesis (GO:0048477)5.20891429
28histone exchange (GO:0043486)5.18953484
29adenine nucleotide transport (GO:0051503)5.18934579
30male sex determination (GO:0030238)5.14957436
31regulation of meiosis I (GO:0060631)5.06250329
32male meiosis (GO:0007140)5.01765083
33cell-cell recognition (GO:0009988)5.01665696
34cellular response to exogenous dsRNA (GO:0071360)4.98283377
35purine nucleotide transport (GO:0015865)4.98176489
36regulation of hydrogen peroxide-induced cell death (GO:1903205)4.93966690
37activation of protein kinase B activity (GO:0032148)4.92978323
38motile cilium assembly (GO:0044458)4.91479167
39TOR signaling (GO:0031929)4.85775840
40cGMP-mediated signaling (GO:0019934)4.84369836
41negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.79459169
42Leydig cell differentiation (GO:0033327)4.76566766
43regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.64486519
44positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.64486519
45histone H3-K9 demethylation (GO:0033169)4.64098985
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.59436153
47indole-containing compound catabolic process (GO:0042436)4.46211456
48indolalkylamine catabolic process (GO:0046218)4.46211456
49tryptophan catabolic process (GO:0006569)4.46211456
50meiotic cell cycle process (GO:1903046)4.35969259
51single fertilization (GO:0007338)4.35342373
52negative regulation of response to reactive oxygen species (GO:1901032)4.34559019
53protein polymerization (GO:0051258)4.34132846
54meiosis I (GO:0007127)4.32289982
55axonemal dynein complex assembly (GO:0070286)4.29279660
56sperm motility (GO:0030317)4.28314073
57regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.27870245
58cellular process involved in reproduction in multicellular organism (GO:0022412)4.26720960
59negative regulation of inclusion body assembly (GO:0090084)4.21311911
60regulation of dopamine secretion (GO:0014059)4.17699585
61acrosome reaction (GO:0007340)4.14577525
62aromatic amino acid family catabolic process (GO:0009074)4.13496816
63glutamine family amino acid catabolic process (GO:0009065)4.11075183
64glycogen metabolic process (GO:0005977)4.10787364
65binding of sperm to zona pellucida (GO:0007339)4.10466046
66cellular glucan metabolic process (GO:0006073)4.06091359
67glucan metabolic process (GO:0044042)4.06091359
68cellular biogenic amine biosynthetic process (GO:0042401)4.02528846
69tryptophan metabolic process (GO:0006568)3.99360285
70negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.99268345
71kynurenine metabolic process (GO:0070189)3.98946841
72positive regulation of glycolytic process (GO:0045821)3.98486897
73regulation of cellular respiration (GO:0043457)3.98127303
74regulation of autophagic vacuole assembly (GO:2000785)3.97803964
75response to acidic pH (GO:0010447)3.94641766
76androgen biosynthetic process (GO:0006702)3.93845102
77amine biosynthetic process (GO:0009309)3.92860473
78L-phenylalanine catabolic process (GO:0006559)3.91782161
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91782161
80female gamete generation (GO:0007292)3.90001049
81mitochondrion degradation (GO:0000422)3.88534012
82membrane repolarization during action potential (GO:0086011)3.86708425
83regulation of bile acid biosynthetic process (GO:0070857)3.85443276
84calcium ion-dependent exocytosis (GO:0017156)3.83168034
85tongue development (GO:0043586)3.78602057
86ventricular system development (GO:0021591)3.73799718
87spermatid development (GO:0007286)3.71182474
88urea metabolic process (GO:0019627)3.71177467
89urea cycle (GO:0000050)3.71177467
90L-phenylalanine metabolic process (GO:0006558)3.68009434
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68009434
92homocysteine metabolic process (GO:0050667)3.65556595
93positive regulation of defense response to virus by host (GO:0002230)3.60259792
94notochord development (GO:0030903)3.59001609
95DNA methylation involved in gamete generation (GO:0043046)3.58014909
96DNA double-strand break processing (GO:0000729)3.56828999
97aspartate family amino acid catabolic process (GO:0009068)3.53371197
98histone H3-K36 demethylation (GO:0070544)3.52736115
99polyamine metabolic process (GO:0006595)3.52007789
100coenzyme catabolic process (GO:0009109)3.49453109
101fertilization (GO:0009566)3.47768552
102cilium movement (GO:0003341)3.44790509
103regulation of phosphatase activity (GO:0010921)3.39621684
104regulation of synaptic transmission, dopaminergic (GO:0032225)3.39470963
105epithelial cilium movement (GO:0003351)3.38169547
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36092692
107resolution of meiotic recombination intermediates (GO:0000712)3.34044622
108regulation of vacuole organization (GO:0044088)3.33570876
109amine catabolic process (GO:0009310)3.33537477
110cellular biogenic amine catabolic process (GO:0042402)3.33537477
111diacylglycerol metabolic process (GO:0046339)3.33078708
112superoxide anion generation (GO:0042554)3.32356492
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30856053
114phosphatidylethanolamine biosynthetic process (GO:0006646)3.30173373
115regulation of memory T cell differentiation (GO:0043380)3.28461833
116nitrogen cycle metabolic process (GO:0071941)3.28185754
117positive regulation of amine transport (GO:0051954)3.27881162
118sister chromatid cohesion (GO:0007062)3.27819466
119membrane repolarization (GO:0086009)3.27376632
120negative regulation of smooth muscle contraction (GO:0045986)3.26797895
121gamete generation (GO:0007276)3.23888500
122sperm capacitation (GO:0048240)3.22859040
123meiotic chromosome segregation (GO:0045132)3.19017746
124gene silencing by RNA (GO:0031047)3.17308982
125sex differentiation (GO:0007548)3.15999671
126cellular response to interferon-beta (GO:0035458)3.14256576
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.12366801
128cellular extravasation (GO:0045123)3.09211462
129positive regulation of meiotic cell cycle (GO:0051446)3.07710465
130negative regulation of JNK cascade (GO:0046329)3.04945371
131regulation of defense response to virus by host (GO:0050691)3.04184903
132cellular response to toxic substance (GO:0097237)3.03988004
133phosphatidylethanolamine metabolic process (GO:0046337)3.01728671
134negative regulation of T cell mediated immunity (GO:0002710)3.01338000
135male meiosis I (GO:0007141)2.99941141
136organic cation transport (GO:0015695)2.96765780
137positive regulation of T-helper cell differentiation (GO:0045624)2.95696365
138opsonization (GO:0008228)2.93628289
139indolalkylamine metabolic process (GO:0006586)2.91876349
140positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91640299
141acute-phase response (GO:0006953)2.90783614
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89881572
143positive regulation of monocyte chemotaxis (GO:0090026)2.89462438
144regulation of centriole replication (GO:0046599)2.86284961
145natural killer cell activation involved in immune response (GO:0002323)2.85607563
146complement activation, alternative pathway (GO:0006957)2.84652334
147microtubule depolymerization (GO:0007019)2.81518748
148synaptonemal complex organization (GO:0070193)2.80243281
149synaptonemal complex assembly (GO:0007130)2.79557989
150aromatic amino acid family metabolic process (GO:0009072)2.78721765
151triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77976999
152epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76479289
153activated T cell proliferation (GO:0050798)2.71755397
154bile acid biosynthetic process (GO:0006699)2.70203005
155centriole assembly (GO:0098534)2.67588042
156high-density lipoprotein particle remodeling (GO:0034375)2.66916898
157regulation of protein activation cascade (GO:2000257)2.65929573
158positive regulation of macrophage cytokine production (GO:0060907)2.61272760
159positive regulation of T-helper 1 type immune response (GO:0002827)2.61075042
160regulation of triglyceride catabolic process (GO:0010896)2.56789391
161regulation of mononuclear cell migration (GO:0071675)2.56245675
162response to dietary excess (GO:0002021)2.55362746
163positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55304093
164regulation of T-helper 1 cell differentiation (GO:0045625)2.53100091
165regulation of complement activation (GO:0030449)2.50282957
166spermatogenesis (GO:0007283)2.49690384
167male gamete generation (GO:0048232)2.48793645
168centriole replication (GO:0007099)2.47985233
169regulation of fibrinolysis (GO:0051917)2.46853962
170detection of molecule of bacterial origin (GO:0032490)2.46654611
171regulation of MHC class I biosynthetic process (GO:0045343)2.45679897
172opioid receptor signaling pathway (GO:0038003)2.44540130
173synapsis (GO:0007129)10.9284872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.39504076
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.23718375
3VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.27555489
4EZH2_22144423_ChIP-Seq_EOC_Human3.21318000
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12959836
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.91180953
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88417872
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.82505580
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.79312094
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.61280115
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52702244
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52156618
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48941530
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47405224
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.40447617
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35124234
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31362791
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28094406
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.28087192
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27818227
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14245361
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.01778610
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.01728238
24AHR_22903824_ChIP-Seq_MCF-7_Human2.00841338
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.3046155
26AR_21909140_ChIP-Seq_LNCAP_Human1.99891790
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.99108838
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.89518723
29KDM2B_26808549_Chip-Seq_REH_Human1.89223085
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.88459485
31NANOG_20526341_ChIP-Seq_ESCs_Human1.85497241
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.84152004
33VDR_22108803_ChIP-Seq_LS180_Human1.83381844
34CRX_20693478_ChIP-Seq_RETINA_Mouse1.76703325
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.76354451
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74097819
37P53_22387025_ChIP-Seq_ESCs_Mouse1.73402685
38ERA_21632823_ChIP-Seq_H3396_Human1.73128047
39EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71868024
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.70573656
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.70247396
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.70061967
43STAT1_17558387_ChIP-Seq_HELA_Human1.68744964
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.68527471
45RAC3_21632823_ChIP-Seq_H3396_Human1.67949501
46OCT4_21477851_ChIP-Seq_ESCs_Mouse1.65531680
47P300_18555785_Chip-Seq_ESCs_Mouse1.64248553
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.63793140
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.61636092
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60986438
51ESRRB_18555785_Chip-Seq_ESCs_Mouse1.60029829
52OCT1_27270436_Chip-Seq_PROSTATE_Human1.59302530
53GBX2_23144817_ChIP-Seq_PC3_Human1.57797799
54RUNX1_27457419_Chip-Seq_LIVER_Mouse1.57524612
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56921988
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.56134689
57NMYC_18555785_Chip-Seq_ESCs_Mouse1.56090393
58HTT_18923047_ChIP-ChIP_STHdh_Human1.55440349
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54571320
60SMAD1_18555785_Chip-Seq_ESCs_Mouse1.54106093
61PU1_27457419_Chip-Seq_LIVER_Mouse1.53764520
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53406866
63GATA1_22025678_ChIP-Seq_K562_Human1.52352120
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51435756
65OCT4_20526341_ChIP-Seq_ESCs_Human1.50816259
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50651568
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49795749
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.48639987
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.48192260
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.47997422
71* FUS_26573619_Chip-Seq_HEK293_Human1.47192159
72ZNF274_21170338_ChIP-Seq_K562_Hela1.47018258
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.45303803
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.44918681
75MYC_19829295_ChIP-Seq_ESCs_Human1.43048695
76ZFX_18555785_Chip-Seq_ESCs_Mouse1.42179987
77SMC4_20622854_ChIP-Seq_HELA_Human1.41833682
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.40340071
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.38174113
80* IGF1R_20145208_ChIP-Seq_DFB_Human1.36798757
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36098949
82TBL1_22424771_ChIP-Seq_293T_Human1.35450186
83ERG_20517297_ChIP-Seq_VCAP_Human1.32758514
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31998737
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31867923
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31486796
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30837209
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28476237
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28476237
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28460435
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28258640
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27381267
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26367491
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25747726
95CTCF_27219007_Chip-Seq_Bcells_Human1.25378742
96* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25097578
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25071667
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23954046
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23668825
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.23196673
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22489891
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22476513
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20683869
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19050526
105AR_21572438_ChIP-Seq_LNCaP_Human1.17812917
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.17600743
107P300_19829295_ChIP-Seq_ESCs_Human1.16279971
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.15877474
109BCAT_22108803_ChIP-Seq_LS180_Human1.14924839
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14476414
111* SMAD4_21799915_ChIP-Seq_A2780_Human1.12240609
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12093340
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.09108241
114NANOG_19829295_ChIP-Seq_ESCs_Human1.09079448
115SOX2_19829295_ChIP-Seq_ESCs_Human1.09079448
116ER_23166858_ChIP-Seq_MCF-7_Human1.08436224
117AR_25329375_ChIP-Seq_VCAP_Human1.06951987
118IRF1_19129219_ChIP-ChIP_H3396_Human1.06089313
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05741073
120* STAT3_23295773_ChIP-Seq_U87_Human1.04897425
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04661027
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04217583
123CTCF_20526341_ChIP-Seq_ESCs_Human1.04124622
124E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03709870
125ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02702375
126IRF8_22096565_ChIP-ChIP_GC-B_Human1.02246009
127TAF15_26573619_Chip-Seq_HEK293_Human1.01797397
128* HOXB7_26014856_ChIP-Seq_BT474_Human1.01631521
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01604422
130FOXH1_21741376_ChIP-Seq_EPCs_Human1.01150269
131CDX2_22108803_ChIP-Seq_LS180_Human1.01001019
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00946278
133RNF2_27304074_Chip-Seq_NSC_Mouse0.99898650
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98754694
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98611396
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98512563
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.98229307
138GATA3_21867929_ChIP-Seq_TH1_Mouse0.98141685
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97755498
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97465587
141IRF8_27001747_Chip-Seq_BMDM_Mouse0.95411250
142P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95190632
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94406165
144TCF4_23295773_ChIP-Seq_U87_Human0.93811040
145RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93696146
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93322273
147PHF8_20622854_ChIP-Seq_HELA_Human0.92951892
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92611239
149SPI1_20517297_ChIP-Seq_HL60_Human0.92492793
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92420591
151GATA3_21878914_ChIP-Seq_MCF-7_Human0.92257103
152PHF8_20622853_ChIP-Seq_HELA_Human0.91953128
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91605296
154RUNX2_22187159_ChIP-Seq_PCA_Human0.91559801
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91476704
156GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90673402
157TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90364162
158ZNF263_19887448_ChIP-Seq_K562_Human0.90361275
159CBP_20019798_ChIP-Seq_JUKART_Human0.90185279
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90185279
161RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90114242
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89671797
163NFYB_21822215_ChIP-Seq_K562_Human0.88272964
164P300_27268052_Chip-Seq_Bcells_Human0.88039313
165TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86100684
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85283312
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85209698
168MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85108945
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.83750160
170P68_20966046_ChIP-Seq_HELA_Human0.83664961
171EWS_26573619_Chip-Seq_HEK293_Human0.82924763
172FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82912540
173CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82451750
174MYC_18940864_ChIP-ChIP_HL60_Human0.82422821
175FOXM1_23109430_ChIP-Seq_U2OS_Human0.80983228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003315_abnormal_perineum_morphology6.04721200
2MP0005360_urolithiasis5.53084667
3MP0002139_abnormal_hepatobiliary_system5.47490310
4MP0002102_abnormal_ear_morphology5.09259265
5MP0005410_abnormal_fertilization5.07282853
6MP0006082_CNS_inflammation4.46796884
7MP0005085_abnormal_gallbladder_physiolo4.35404773
8MP0002160_abnormal_reproductive_system4.34480127
9MP0005365_abnormal_bile_salt4.01421780
10MP0003252_abnormal_bile_duct2.89442266
11MP0005451_abnormal_body_composition2.52744465
12MP0009785_altered_susceptibility_to2.46530578
13MP0005058_abnormal_lysosome_morphology2.45986762
14MP0008875_abnormal_xenobiotic_pharmacok2.38407104
15MP0009764_decreased_sensitivity_to2.37882454
16MP0001929_abnormal_gametogenesis2.26094777
17MP0003045_fibrosis2.25438028
18MP0008995_early_reproductive_senescence2.22554496
19MP0004484_altered_response_of2.21916321
20MP0005389_reproductive_system_phenotype2.21321376
21MP0002735_abnormal_chemical_nociception2.13730627
22MP0002138_abnormal_hepatobiliary_system2.06854902
23MP0003698_abnormal_male_reproductive2.06185198
24MP0003724_increased_susceptibility_to2.01295028
25MP0001664_abnormal_digestion2.01252390
26MP0001984_abnormal_olfaction2.01249908
27MP0000537_abnormal_urethra_morphology1.98035192
28MP0010368_abnormal_lymphatic_system1.90341005
29MP0005394_taste/olfaction_phenotype1.90150783
30MP0005499_abnormal_olfactory_system1.90150783
31MP0003136_yellow_coat_color1.79017483
32MP0002210_abnormal_sex_determination1.77636403
33MP0008058_abnormal_DNA_repair1.77516259
34MP0000566_synostosis1.74870906
35MP0004019_abnormal_vitamin_homeostasis1.66852280
36MP0008877_abnormal_DNA_methylation1.65982091
37MP0001188_hyperpigmentation1.63705806
38MP0010329_abnormal_lipoprotein_level1.62382376
39MP0005083_abnormal_biliary_tract1.58945889
40MP0005647_abnormal_sex_gland1.57913708
41MP0003195_calcinosis1.52576463
42MP0005187_abnormal_penis_morphology1.50347100
43MP0005166_decreased_susceptibility_to1.44909566
44MP0000653_abnormal_sex_gland1.44050842
45MP0002148_abnormal_hypersensitivity_rea1.43268372
46MP0002653_abnormal_ependyma_morphology1.42153117
47MP0004782_abnormal_surfactant_physiolog1.41327667
48MP0001666_abnormal_nutrient_absorption1.36982582
49MP0005025_abnormal_response_to1.32766664
50MP0001145_abnormal_male_reproductive1.32022523
51MP0005332_abnormal_amino_acid1.31106105
52MP0002234_abnormal_pharynx_morphology1.27478965
53MP0008469_abnormal_protein_level1.26227747
54MP0002419_abnormal_innate_immunity1.26129658
55MP0000678_abnormal_parathyroid_gland1.25888496
56MP0000343_altered_response_to1.25084425
57MP0002168_other_aberrant_phenotype1.24666886
58MP0001119_abnormal_female_reproductive1.23612582
59MP0003646_muscle_fatigue1.22923482
60MP0002161_abnormal_fertility/fecundity1.22480924
61MP0009697_abnormal_copulation1.22210419
62MP0003936_abnormal_reproductive_system1.20069602
63MP0001905_abnormal_dopamine_level1.19014042
64MP0002876_abnormal_thyroid_physiology1.18945624
65MP0005623_abnormal_meninges_morphology1.14950804
66MP0001346_abnormal_lacrimal_gland1.14422042
67MP0000609_abnormal_liver_physiology1.14226525
68MP0005395_other_phenotype1.14044225
69MP0003436_decreased_susceptibility_to1.10795920
70MP0001764_abnormal_homeostasis1.09298740
71MP0002928_abnormal_bile_duct1.09070632
72MP0006072_abnormal_retinal_apoptosis1.08227055
73MP0002118_abnormal_lipid_homeostasis1.06406453
74MP0001919_abnormal_reproductive_system1.05592553
75MP0001849_ear_inflammation1.05077100
76MP0000579_abnormal_nail_morphology1.03416085
77MP0003690_abnormal_glial_cell1.02047662
78MP0005535_abnormal_body_temperature1.01797376
79MP0006036_abnormal_mitochondrial_physio0.97732957
80MP0008789_abnormal_olfactory_epithelium0.96327304
81MP0004510_myositis0.96195191
82MP0005248_abnormal_Harderian_gland0.94040957
83MP0005000_abnormal_immune_tolerance0.93960221
84MP0002249_abnormal_larynx_morphology0.93884390
85MP0002006_tumorigenesis0.93826056
86MP0001661_extended_life_span0.93714539
87MP0004084_abnormal_cardiac_muscle0.92513147
88MP0003868_abnormal_feces_composition0.92359696
89MP0003718_maternal_effect0.91061597
90MP0002127_abnormal_cardiovascular_syste0.90948445
91MP0008004_abnormal_stomach_pH0.90872653
92MP0001845_abnormal_inflammatory_respons0.90800503
93MP0000631_abnormal_neuroendocrine_gland0.89763304
94MP0009763_increased_sensitivity_to0.88047565
95MP0003699_abnormal_female_reproductive0.86484671
96MP0002723_abnormal_immune_serum0.85196828
97MP0005174_abnormal_tail_pigmentation0.84384949
98MP0001529_abnormal_vocalization0.83633944
99MP0000538_abnormal_urinary_bladder0.83017142
100MP0005310_abnormal_salivary_gland0.82784534
101MP0002132_abnormal_respiratory_system0.80701825
102MP0001968_abnormal_touch/_nociception0.80427798
103MP0000465_gastrointestinal_hemorrhage0.79465028
104MP0004085_abnormal_heartbeat0.77635949
105MP0005670_abnormal_white_adipose0.75330321
106MP0000462_abnormal_digestive_system0.74265394
107MP0004036_abnormal_muscle_relaxation0.73944625
108MP0000470_abnormal_stomach_morphology0.72946503
109MP0001800_abnormal_humoral_immune0.72842043
110MP0003632_abnormal_nervous_system0.72459005
111MP0010094_abnormal_chromosome_stability0.71488049
112MP0002277_abnormal_respiratory_mucosa0.71475218
113MP0005253_abnormal_eye_physiology0.71272024
114MP0005387_immune_system_phenotype0.71035989
115MP0001790_abnormal_immune_system0.71035989
116MP0001501_abnormal_sleep_pattern0.70540324
117MP0005319_abnormal_enzyme/_coenzyme0.70397031
118MP0009765_abnormal_xenobiotic_induced0.70251006
119MP0005409_darkened_coat_color0.69932859
120MP0002638_abnormal_pupillary_reflex0.68512510
121MP0002233_abnormal_nose_morphology0.67842977
122MP0002332_abnormal_exercise_endurance0.66590244
123MP0000427_abnormal_hair_cycle0.65475506
124MP0010386_abnormal_urinary_bladder0.65401929
125MP0002452_abnormal_antigen_presenting0.65253613
126MP0005646_abnormal_pituitary_gland0.64669826
127MP0009643_abnormal_urine_homeostasis0.63734362
128MP0004272_abnormal_basement_membrane0.63185784
129MP0005408_hypopigmentation0.61773338
130MP0003693_abnormal_embryo_hatching0.61332692
131MP0010155_abnormal_intestine_physiology0.61143925
132MP0002282_abnormal_trachea_morphology0.60837034
133MP0004947_skin_inflammation0.60428896
134MP0003077_abnormal_cell_cycle0.60339879
135MP0003806_abnormal_nucleotide_metabolis0.60132994
136MP0001835_abnormal_antigen_presentation0.59600951
137MP0003631_nervous_system_phenotype0.59109862
138MP0003938_abnormal_ear_development0.58317038
139MP0002163_abnormal_gland_morphology0.58138696
140MP0002136_abnormal_kidney_physiology0.57783832
141MP0009840_abnormal_foam_cell0.57737590
142MP0003879_abnormal_hair_cell0.55972615
143MP0003453_abnormal_keratinocyte_physiol0.55963140
144MP0004381_abnormal_hair_follicle0.51068984
145MP0003890_abnormal_embryonic-extraembry0.50682335
146MP0005551_abnormal_eye_electrophysiolog0.50443592
147MP0000230_abnormal_systemic_arterial0.49548652
148MP0002272_abnormal_nervous_system0.48294444
149MP0006035_abnormal_mitochondrial_morpho0.48182318
150MP0003385_abnormal_body_wall0.45431506
151MP0009250_abnormal_appendicular_skeleto0.45270098
152MP0000049_abnormal_middle_ear0.42846446
153MP0005167_abnormal_blood-brain_barrier0.40377286
154MP0001270_distended_abdomen0.38361015
155MP0001963_abnormal_hearing_physiology0.38088461
156MP0002108_abnormal_muscle_morphology0.37531206
157MP0003633_abnormal_nervous_system0.36391909
158MP0005620_abnormal_muscle_contractility0.36042187
159MP0000026_abnormal_inner_ear0.35236504
160MP0000015_abnormal_ear_pigmentation0.35058105
161MP0005595_abnormal_vascular_smooth0.35039283
162MP0003935_abnormal_craniofacial_develop0.34966747
163MP0003119_abnormal_digestive_system0.34618854
164MP0002752_abnormal_somatic_nervous0.34377374

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.83220863
2Abnormal sex determination (HP:0012244)7.16430576
3Sex reversal (HP:0012245)7.16430576
4Hypoplasia of the uterus (HP:0000013)7.06577620
5Resting tremor (HP:0002322)7.00730811
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.59084819
7Absent/shortened dynein arms (HP:0200106)6.59084819
8Abnormal respiratory motile cilium physiology (HP:0012261)6.25749631
9Abnormal ciliary motility (HP:0012262)5.69229714
10Aplasia/hypoplasia of the uterus (HP:0008684)5.31241813
11Gonadal dysgenesis (HP:0000133)5.27563202
12Facial hemangioma (HP:0000329)5.06929647
13Abnormality of the columella (HP:0009929)4.88258105
14Reduced antithrombin III activity (HP:0001976)4.72698735
15Male pseudohermaphroditism (HP:0000037)4.66548846
16Abnormal respiratory motile cilium morphology (HP:0005938)4.42347797
17Abnormal respiratory epithelium morphology (HP:0012253)4.42347797
18Rhinitis (HP:0012384)4.39307470
19Postural instability (HP:0002172)4.17007403
20Ventricular fibrillation (HP:0001663)4.12240863
21Colitis (HP:0002583)4.11280379
22Cerebellar dysplasia (HP:0007033)4.04638985
23Urinary urgency (HP:0000012)4.02757758
24Type II lissencephaly (HP:0007260)4.01270117
25Intrahepatic cholestasis (HP:0001406)3.96583962
26Germ cell neoplasia (HP:0100728)3.89883481
27Azoospermia (HP:0000027)3.84570778
28Capillary hemangiomas (HP:0005306)3.69697619
29Thoracic kyphosis (HP:0002942)3.67418999
30Chronic bronchitis (HP:0004469)3.48808078
31Nasal polyposis (HP:0100582)3.46985812
32Infertility (HP:0000789)3.44313149
33Retinal dysplasia (HP:0007973)3.42959673
34Tetany (HP:0001281)3.42474025
35Deep venous thrombosis (HP:0002625)3.40092085
36Abnormality of aromatic amino acid family metabolism (HP:0004338)3.39620385
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24449391
38Recurrent gram-negative bacterial infections (HP:0005420)3.23795039
39Bronchiectasis (HP:0002110)3.20773632
40Epidermoid cyst (HP:0200040)3.20738871
41Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18174577
42Protruding tongue (HP:0010808)3.17393362
43Autoimmune thrombocytopenia (HP:0001973)3.14517257
44Gait imbalance (HP:0002141)3.06787357
45Retinal atrophy (HP:0001105)3.05719134
46Congenital primary aphakia (HP:0007707)3.03688574
47Self-mutilation (HP:0000742)3.02660367
48Prolonged partial thromboplastin time (HP:0003645)3.01839377
49Systemic lupus erythematosus (HP:0002725)2.96856401
50Medial flaring of the eyebrow (HP:0010747)2.91874482
51Nephrogenic diabetes insipidus (HP:0009806)2.90890017
52Abnormal spermatogenesis (HP:0008669)2.90722760
53Spontaneous abortion (HP:0005268)2.89555185
54Thoracolumbar scoliosis (HP:0002944)2.89384142
55Abnormality of the lumbar spine (HP:0100712)2.88792603
56Anterior segment dysgenesis (HP:0007700)2.87351159
57Hypobetalipoproteinemia (HP:0003563)2.75804841
58Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.73011437
59Male infertility (HP:0003251)2.72063865
60Abnormality of the intrinsic pathway (HP:0010989)2.71186538
61Complement deficiency (HP:0004431)2.67881647
62Abnormality of the nasal mucosa (HP:0000433)2.67590436
63Inflammation of the large intestine (HP:0002037)2.66154994
64Abnormality of the thoracic spine (HP:0100711)2.62745338
65Absent thumb (HP:0009777)2.62097183
66Occipital encephalocele (HP:0002085)2.56344561
67Joint hemorrhage (HP:0005261)2.55528300
68Recurrent sinusitis (HP:0011108)2.53507437
69Hyperglycinuria (HP:0003108)2.52721219
70Inability to walk (HP:0002540)2.52715014
71Hypoalphalipoproteinemia (HP:0003233)2.50471056
72Gastrointestinal inflammation (HP:0004386)2.48912279
73Abnormality of the ileum (HP:0001549)2.48909495
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.48024153
75Hypoplasia of the fovea (HP:0007750)2.48024153
76Sensory axonal neuropathy (HP:0003390)2.47920070
77Abnormality of methionine metabolism (HP:0010901)2.47589530
78Congenital sensorineural hearing impairment (HP:0008527)2.47117191
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.46529427
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45819757
81Poor coordination (HP:0002370)2.43459539
82Hypolipoproteinemia (HP:0010981)2.43151388
83Tubulointerstitial nephritis (HP:0001970)2.41913291
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38956589
85Xanthomatosis (HP:0000991)2.37681758
86Hyperammonemia (HP:0001987)2.36680098
87Atonic seizures (HP:0010819)2.34534992
88Conjugated hyperbilirubinemia (HP:0002908)2.33420416
89Meckel diverticulum (HP:0002245)2.33148713
90Vaginal atresia (HP:0000148)2.33088382
91Pigmentary retinal degeneration (HP:0001146)2.32907755
92Elfin facies (HP:0004428)2.32414660
93Unilateral renal agenesis (HP:0000122)2.32151616
94Buphthalmos (HP:0000557)2.30882506
95Hydroxyprolinuria (HP:0003080)2.30335963
96Abnormality of proline metabolism (HP:0010907)2.30335963
97Myocardial infarction (HP:0001658)2.27999210
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26620418
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26620418
100Abnormality of the frontal sinuses (HP:0002687)2.26207521
101Bile duct proliferation (HP:0001408)2.23848588
102Abnormal biliary tract physiology (HP:0012439)2.23848588
103Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.22548299
104Vascular calcification (HP:0004934)2.22087056
105Unsteady gait (HP:0002317)2.20103641
106Genital tract atresia (HP:0001827)2.19435137
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15491696
108Abnormality of pyrimidine metabolism (HP:0004353)2.13237097
109Median cleft lip (HP:0000161)2.11741932
110Abnormal protein glycosylation (HP:0012346)2.11689192
111Abnormal glycosylation (HP:0012345)2.11689192
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11689192
113Abnormal protein N-linked glycosylation (HP:0012347)2.11689192
114Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.09479009
115Spastic paraparesis (HP:0002313)2.08690959
116Cardiovascular calcification (HP:0011915)2.04553659
117Abnormality of male internal genitalia (HP:0000022)2.03379661
118Abnormality of serine family amino acid metabolism (HP:0010894)2.03363118
119Abnormality of glycine metabolism (HP:0010895)2.03363118
120Birth length less than 3rd percentile (HP:0003561)2.02914804
121Hyperglycinemia (HP:0002154)2.02591149
122Hyperlipoproteinemia (HP:0010980)2.01930202
123Joint swelling (HP:0001386)2.01682243
124Dry hair (HP:0011359)2.00106584
125Abnormality of the preputium (HP:0100587)1.99684662
126Abnormality of complement system (HP:0005339)1.99657999
127Aplasia/Hypoplasia of the macula (HP:0008059)1.98273194
128Ectopic kidney (HP:0000086)1.94778469
129Duodenal stenosis (HP:0100867)1.94710600
130Small intestinal stenosis (HP:0012848)1.94710600
131Retrobulbar optic neuritis (HP:0100654)1.93554127
132Optic neuritis (HP:0100653)1.93554127
133Abnormality of DNA repair (HP:0003254)1.93287925
134Syncope (HP:0001279)1.93118366
135Abnormality of chromosome stability (HP:0003220)1.93105340
136Hemorrhage of the eye (HP:0011885)1.91338655
137Spastic tetraparesis (HP:0001285)1.91235061
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89823784
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.88863770
140Gastrointestinal infarctions (HP:0005244)1.86492693
141Difficulty climbing stairs (HP:0003551)1.85735119
142Delayed CNS myelination (HP:0002188)1.84285191
143Abnormality of the fovea (HP:0000493)1.84138924
144Chronic hepatic failure (HP:0100626)1.83636388
145Fat malabsorption (HP:0002630)1.83083120
146Nonprogressive disorder (HP:0003680)1.82412052
147Prolonged neonatal jaundice (HP:0006579)1.82410394
148Absent speech (HP:0001344)1.82239712
149Abnormality of nucleobase metabolism (HP:0010932)1.82153941
150Renovascular hypertension (HP:0100817)1.81140233
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.81067788
152Optic nerve hypoplasia (HP:0000609)1.80939387
153Toxemia of pregnancy (HP:0100603)1.77840272
154Flattened epiphyses (HP:0003071)1.77619032
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75679493
156Chromsome breakage (HP:0040012)1.74970930
157Hypergonadotropic hypogonadism (HP:0000815)1.74329337
158Generalized hypotonia (HP:0001290)1.74240907
159Cortical dysplasia (HP:0002539)1.73624515
160Prolonged QT interval (HP:0001657)1.73623101
161Bradykinesia (HP:0002067)1.73372785
162Abnormality of serum amino acid levels (HP:0003112)1.72403652
163Renal cortical cysts (HP:0000803)1.72168336
164Clubbing of toes (HP:0100760)1.71549785
165Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70303353
166Abnormality of cochlea (HP:0000375)1.69971465
167Gonadotropin excess (HP:0000837)1.69797915
168Chronic sinusitis (HP:0011109)1.68595469
169Proximal tubulopathy (HP:0000114)1.68567382
170Hypercholesterolemia (HP:0003124)1.67713711
171Hypothermia (HP:0002045)1.67535364
172Abnormality of purine metabolism (HP:0004352)1.66612363
173Renal dysplasia (HP:0000110)1.66600446
174Cystic liver disease (HP:0006706)1.65589915
175Hypoplasia of the brainstem (HP:0002365)1.65569263
176Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65569263
177Ketosis (HP:0001946)1.65438642
178Spinal rigidity (HP:0003306)1.65327428
179Pancreatitis (HP:0001733)1.64456642
180Stomatitis (HP:0010280)1.64389514
181Abnormality of the carotid arteries (HP:0005344)1.63718683
182Slender long bone (HP:0003100)1.61833136
183High pitched voice (HP:0001620)1.60949484
184Taurodontia (HP:0000679)1.58264374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK36.11634976
2ZAK4.43155623
3TLK13.96979730
4PDK33.39574643
5PDK43.39574643
6PLK43.36718314
7LATS13.34220122
8TAOK33.07468002
9ADRBK23.04824568
10MYLK2.97519873
11ERBB42.96948162
12MST42.94084615
13RPS6KA52.81553989
14STK38L2.76102368
15IRAK32.74084598
16NEK22.57264371
17TXK2.55843747
18MAP3K132.48132096
19CAMK1D2.32199036
20MAP3K62.29872321
21PDK22.25967444
22LMTK22.16580903
23PRPF4B2.13859092
24TBK12.13518854
25LATS22.05000575
26PINK111.4586067
27OBSCN1.91073371
28PASK1.84960143
29FGR1.62572610
30STK31.60433866
31BCKDK1.54307318
32MAP3K141.54160637
33PIK3CG1.42018293
34BCR1.39686560
35GRK71.33456552
36IKBKE1.27646277
37NME11.25586277
38PNCK1.23805105
39MAP2K71.22111179
40PRKAA21.19362811
41MAP3K91.14714404
42CDK31.14103513
43RPS6KA41.11618405
44JAK31.11129010
45ARAF1.09353896
46CAMK1G1.07446105
47CSK1.03850747
48MAP2K41.02529881
49STK380.97154016
50MST1R0.94417592
51VRK10.93079606
52SGK4940.91852794
53SGK2230.91852794
54MET0.91774877
55CHEK20.90706239
56NTRK10.89574701
57NUAK10.86147757
58PLK20.84557668
59BMPR1B0.84472106
60PRKD30.84383065
61DYRK30.83321215
62EIF2AK30.82814052
63CASK0.80917883
64MAP2K60.80220455
65IKBKB0.79084436
66PIM10.76499240
67PKN10.74180174
68WNK30.73982436
69EIF2AK20.72156631
70ABL20.72051535
71IRAK10.71372663
72STK40.71026668
73CDK140.70998673
74CAMKK10.70077184
75PRKCQ0.69170203
76MAP3K40.67569859
77IRAK40.67328683
78JAK10.65125012
79MAP3K50.63054388
80RET0.61034053
81MAPK150.60825825
82NTRK20.60702810
83PRKCZ0.60632444
84RPS6KB10.59849822
85YES10.59490726
86TGFBR10.59293190
87PTK2B0.58776914
88NTRK30.57932380
89PBK0.57572080
90CDK120.57329830
91ATM0.57220617
92STK390.57151116
93PDK10.56150877
94PLK10.56095642
95CSNK1A1L0.55315998
96CDC42BPA0.54884076
97PRKG20.54278358
98ABL10.54131191
99CDK80.53556025
100PAK10.52123380
101KSR20.52090873
102BMPR20.51414879
103MAP3K10.50741752
104CAMK2A0.49578952
105FRK0.48771079
106TTK0.48357720
107CAMK40.46098615
108PAK20.46094337
109CDK190.45163669
110CAMK10.44641847
111CSNK1G30.42686551
112SGK10.42441062
113ACVR1B0.42267896
114AKT20.41008179
115EPHA30.40878754
116INSRR0.40378089
117MAP3K100.40315301
118ROCK10.40240021
119ICK0.38928928
120EGFR0.38869021
121AURKA0.37856469
122CHUK0.37835287
123JAK20.35747323
124WNK10.33998999
125MELK0.33805110
126CSNK1G10.33721281
127CDK50.33278220
128PAK60.33083057
129CCNB10.33073830
130PRKG10.32937747
131NEK60.32876115
132AKT30.31910881
133BRAF0.31750971
134CSNK1D0.30222766
135PDPK10.29473978
136MTOR0.28665935
137CSNK1G20.28382422
138FGFR20.28220235
139MAP3K20.27746576
140EEF2K0.27733877
141WEE10.25799204
142TAOK20.25660641
143ATR0.25405888
144MOS0.25400441
145MUSK0.25326857
146PRKAA10.25271009
147STK110.24812776
148RIPK10.24744563
149AURKB0.24453706
150PAK30.24439908
151DAPK30.24250698
152DYRK20.24129403
153CLK10.23982309
154RPS6KA10.23369287
155SGK20.21647643
156TIE10.21538395
157RPS6KA30.18532303
158CHEK10.18038619
159RAF10.17139910
160MAPK10.17078409
161TYRO30.16890810
162ILK0.16704245
163NME20.15879935
164CSNK1A10.14877155
165WNK40.13020063
166CDK70.10932709

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051307.75772390
2Gap junction_Homo sapiens_hsa045405.27153921
3Graft-versus-host disease_Homo sapiens_hsa053323.62721555
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.29375766
5Systemic lupus erythematosus_Homo sapiens_hsa053223.08606528
6Hedgehog signaling pathway_Homo sapiens_hsa043403.08600302
7Propanoate metabolism_Homo sapiens_hsa006402.94422137
8Apoptosis_Homo sapiens_hsa042102.88098500
9Alcoholism_Homo sapiens_hsa050342.47347796
10Staphylococcus aureus infection_Homo sapiens_hsa051502.37931961
11Olfactory transduction_Homo sapiens_hsa047402.33293658
12Complement and coagulation cascades_Homo sapiens_hsa046102.32831911
13PPAR signaling pathway_Homo sapiens_hsa033202.31569435
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30900751
15Selenocompound metabolism_Homo sapiens_hsa004502.22990601
16Tryptophan metabolism_Homo sapiens_hsa003802.18300525
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14859129
18Fatty acid degradation_Homo sapiens_hsa000712.14664662
19Vitamin B6 metabolism_Homo sapiens_hsa007502.12665623
20Type I diabetes mellitus_Homo sapiens_hsa049402.05144351
21Nitrogen metabolism_Homo sapiens_hsa009102.04845796
22Arginine biosynthesis_Homo sapiens_hsa002202.02076797
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97087841
24Dorso-ventral axis formation_Homo sapiens_hsa043201.77399307
25Rheumatoid arthritis_Homo sapiens_hsa053231.74961235
26Allograft rejection_Homo sapiens_hsa053301.73001300
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71690270
28Oocyte meiosis_Homo sapiens_hsa041141.71363671
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64905485
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61490544
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58422427
32TNF signaling pathway_Homo sapiens_hsa046681.56523569
33Chemical carcinogenesis_Homo sapiens_hsa052041.51007518
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.49081826
35Fatty acid biosynthesis_Homo sapiens_hsa000611.46028563
36Histidine metabolism_Homo sapiens_hsa003401.45190126
37Peroxisome_Homo sapiens_hsa041461.43478663
38Retinol metabolism_Homo sapiens_hsa008301.42410557
39beta-Alanine metabolism_Homo sapiens_hsa004101.39537238
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38025564
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35863640
42Fatty acid metabolism_Homo sapiens_hsa012121.35155530
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33059325
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32431065
45mRNA surveillance pathway_Homo sapiens_hsa030151.31224890
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30382063
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30378211
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29916456
49Vitamin digestion and absorption_Homo sapiens_hsa049771.29100437
50Legionellosis_Homo sapiens_hsa051341.26434630
51RNA transport_Homo sapiens_hsa030131.25021786
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23863756
53Autoimmune thyroid disease_Homo sapiens_hsa053201.21390724
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.20957441
55Caffeine metabolism_Homo sapiens_hsa002321.20004611
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19617388
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15863060
58Glutathione metabolism_Homo sapiens_hsa004801.12627595
59Bile secretion_Homo sapiens_hsa049761.12626175
60Malaria_Homo sapiens_hsa051441.12346991
61Pyruvate metabolism_Homo sapiens_hsa006201.11416810
62Butanoate metabolism_Homo sapiens_hsa006501.11089169
63ABC transporters_Homo sapiens_hsa020101.09973577
64Steroid biosynthesis_Homo sapiens_hsa001001.08042353
65DNA replication_Homo sapiens_hsa030301.07324545
66Prion diseases_Homo sapiens_hsa050201.01140693
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01092599
68Intestinal immune network for IgA production_Homo sapiens_hsa046721.00430826
69Leishmaniasis_Homo sapiens_hsa051401.00393015
70African trypanosomiasis_Homo sapiens_hsa051431.00104454
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96396815
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.96160017
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94550330
74Phenylalanine metabolism_Homo sapiens_hsa003600.93350840
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91367659
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.90767842
77Pertussis_Homo sapiens_hsa051330.89459223
78Homologous recombination_Homo sapiens_hsa034400.89221263
79Salmonella infection_Homo sapiens_hsa051320.89170547
80Tuberculosis_Homo sapiens_hsa051520.88774537
81Linoleic acid metabolism_Homo sapiens_hsa005910.87456919
82Tyrosine metabolism_Homo sapiens_hsa003500.87193413
83Folate biosynthesis_Homo sapiens_hsa007900.82750424
84Cell cycle_Homo sapiens_hsa041100.82545253
85RNA degradation_Homo sapiens_hsa030180.80008151
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79967700
87Circadian rhythm_Homo sapiens_hsa047100.79080070
88Sulfur relay system_Homo sapiens_hsa041220.78527730
89Taste transduction_Homo sapiens_hsa047420.78167371
90Glycerolipid metabolism_Homo sapiens_hsa005610.77590115
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73774492
92Herpes simplex infection_Homo sapiens_hsa051680.72874926
93Hematopoietic cell lineage_Homo sapiens_hsa046400.69754054
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69405404
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68939759
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.67587483
97Regulation of autophagy_Homo sapiens_hsa041400.67391372
98Fat digestion and absorption_Homo sapiens_hsa049750.66463819
99TGF-beta signaling pathway_Homo sapiens_hsa043500.63491646
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62338640
101Glucagon signaling pathway_Homo sapiens_hsa049220.61022868
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.60767468
103Nucleotide excision repair_Homo sapiens_hsa034200.60155546
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58940918
105Amoebiasis_Homo sapiens_hsa051460.58578803
106Purine metabolism_Homo sapiens_hsa002300.58082976
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57335420
108Pentose phosphate pathway_Homo sapiens_hsa000300.57294231
109Oxytocin signaling pathway_Homo sapiens_hsa049210.57198920
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56908995
111Measles_Homo sapiens_hsa051620.56591455
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56524121
113Arginine and proline metabolism_Homo sapiens_hsa003300.55993320
114Starch and sucrose metabolism_Homo sapiens_hsa005000.55100187
115Basal transcription factors_Homo sapiens_hsa030220.53165480
116Ether lipid metabolism_Homo sapiens_hsa005650.52631901
117Influenza A_Homo sapiens_hsa051640.52594397
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52034289
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50772087
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50747345
121Ovarian steroidogenesis_Homo sapiens_hsa049130.49991615
122Osteoclast differentiation_Homo sapiens_hsa043800.48496755
123Choline metabolism in cancer_Homo sapiens_hsa052310.46414174
124Calcium signaling pathway_Homo sapiens_hsa040200.43865926
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.42986697
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41342682
127N-Glycan biosynthesis_Homo sapiens_hsa005100.41274582
128Hepatitis B_Homo sapiens_hsa051610.41177117
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41174444
130Gastric acid secretion_Homo sapiens_hsa049710.41161772
131mTOR signaling pathway_Homo sapiens_hsa041500.40299778
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39641344
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39043612
134Renin secretion_Homo sapiens_hsa049240.38477218
135Mismatch repair_Homo sapiens_hsa034300.37420127
136Carbon metabolism_Homo sapiens_hsa012000.35905840
137Viral carcinogenesis_Homo sapiens_hsa052030.35817552
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35807232
139Endometrial cancer_Homo sapiens_hsa052130.35513871
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32877463
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.32765890
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32471102
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31055085
144Wnt signaling pathway_Homo sapiens_hsa043100.30872808
145Fanconi anemia pathway_Homo sapiens_hsa034600.29683178
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.29217710
147Arachidonic acid metabolism_Homo sapiens_hsa005900.28513456
148Biosynthesis of amino acids_Homo sapiens_hsa012300.27452972
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.27139779
150Phagosome_Homo sapiens_hsa041450.26994202
151Estrogen signaling pathway_Homo sapiens_hsa049150.26780311
152Circadian entrainment_Homo sapiens_hsa047130.25835196
153Chemokine signaling pathway_Homo sapiens_hsa040620.25609177
154Metabolic pathways_Homo sapiens_hsa011000.24242859
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23184226
156Prostate cancer_Homo sapiens_hsa052150.20628280
157Melanoma_Homo sapiens_hsa052180.20449434
158Phototransduction_Homo sapiens_hsa047440.18509098
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.17441054
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16816466
161FoxO signaling pathway_Homo sapiens_hsa040680.15830699
162Pyrimidine metabolism_Homo sapiens_hsa002400.14371150
163MAPK signaling pathway_Homo sapiens_hsa040100.13674801
164Synaptic vesicle cycle_Homo sapiens_hsa047210.11381954
165VEGF signaling pathway_Homo sapiens_hsa043700.11362771
166AMPK signaling pathway_Homo sapiens_hsa041520.11311606
167GABAergic synapse_Homo sapiens_hsa047270.10414278

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