TPTE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.10438324
2sperm motility (GO:0030317)8.96421852
3spermatid development (GO:0007286)7.19854562
4fusion of sperm to egg plasma membrane (GO:0007342)6.88411195
5multicellular organism reproduction (GO:0032504)6.06378999
6sperm-egg recognition (GO:0035036)5.90421168
7binding of sperm to zona pellucida (GO:0007339)5.77173079
8single strand break repair (GO:0000012)5.71792633
9microtubule depolymerization (GO:0007019)5.65320907
10response to pheromone (GO:0019236)5.61789538
11male meiosis (GO:0007140)5.53779970
12centriole replication (GO:0007099)5.48474159
13muscle organ morphogenesis (GO:0048644)5.42345139
14regulation of phosphoprotein phosphatase activity (GO:0043666)5.41291346
15motile cilium assembly (GO:0044458)5.34691516
16plasma membrane fusion (GO:0045026)5.12932415
17rRNA methylation (GO:0031167)5.12811696
18centriole assembly (GO:0098534)5.12067217
19axonemal dynein complex assembly (GO:0070286)5.05188873
20cilium or flagellum-dependent cell motility (GO:0001539)5.00893152
21sperm capacitation (GO:0048240)4.97805694
22reproduction (GO:0000003)4.96418421
23single fertilization (GO:0007338)4.90136917
24cell-cell recognition (GO:0009988)4.88540150
25detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.81281984
26chromosome condensation (GO:0030261)4.80991701
27microtubule polymerization or depolymerization (GO:0031109)4.79070275
28DNA packaging (GO:0006323)4.69371749
29establishment of protein localization to Golgi (GO:0072600)4.64042344
30protein targeting to Golgi (GO:0000042)4.60132719
31calcium ion-dependent exocytosis (GO:0017156)4.59052928
32epithelial cilium movement (GO:0003351)4.57274782
33phosphatidylethanolamine biosynthetic process (GO:0006646)4.51693517
34rRNA modification (GO:0000154)4.51531775
35microtubule severing (GO:0051013)4.37063247
36spermatid nucleus differentiation (GO:0007289)4.35953457
37spermatogenesis (GO:0007283)4.33615386
38male gamete generation (GO:0048232)4.32888586
39phosphatidylethanolamine metabolic process (GO:0046337)4.19005976
40male sex determination (GO:0030238)4.15491570
41retrograde transport, vesicle recycling within Golgi (GO:0000301)4.12171800
42cellular ketone body metabolic process (GO:0046950)3.99273070
43gamete generation (GO:0007276)3.99130631
44germ cell development (GO:0007281)3.98530577
45protein-DNA complex disassembly (GO:0032986)3.98233745
46nucleosome disassembly (GO:0006337)3.98233745
47coenzyme catabolic process (GO:0009109)3.95222552
48organic cation transport (GO:0015695)3.94848876
49protein polyglutamylation (GO:0018095)3.88108370
50negative regulation of inclusion body assembly (GO:0090084)3.84316816
51regulation of centriole replication (GO:0046599)3.83707016
52synapsis (GO:0007129)3.82620432
53protein localization to Golgi apparatus (GO:0034067)3.76758896
54adrenergic receptor signaling pathway (GO:0071875)3.70007281
55cilium movement (GO:0003341)3.67354046
56fertilization (GO:0009566)3.64355958
57positive regulation of catecholamine secretion (GO:0033605)3.53843455
58cellular process involved in reproduction in multicellular organism (GO:0022412)3.46457816
59ketone body metabolic process (GO:1902224)3.45206967
60polyamine biosynthetic process (GO:0006596)3.42961801
61dorsal/ventral neural tube patterning (GO:0021904)3.42956561
62peripheral nervous system neuron development (GO:0048935)3.34642125
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32075171
64piRNA metabolic process (GO:0034587)3.31094903
65histone exchange (GO:0043486)3.24215653
66histone H3-K9 demethylation (GO:0033169)3.16527941
67multicellular organismal reproductive process (GO:0048609)3.16049693
68regulation of Rab GTPase activity (GO:0032313)3.15633103
69positive regulation of Rab GTPase activity (GO:0032851)3.15633103
70regulation of cilium movement (GO:0003352)3.15408346
71RNA destabilization (GO:0050779)3.13803944
72meiotic nuclear division (GO:0007126)3.12968063
73negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.10665414
74detection of chemical stimulus involved in sensory perception (GO:0050907)3.08891116
75sensory perception of smell (GO:0007608)3.04442622
76outer ear morphogenesis (GO:0042473)3.04373049
77DNA synthesis involved in DNA repair (GO:0000731)3.00921257
78male meiosis I (GO:0007141)2.97547884
79regulation of transcription involved in cell fate commitment (GO:0060850)2.95635753
80chromosome organization involved in meiosis (GO:0070192)2.94759784
81microtubule nucleation (GO:0007020)2.91617927
82centrosome duplication (GO:0051298)2.91272775
83regulation of meiosis I (GO:0060631)2.90767326
84ventricular system development (GO:0021591)2.90084167
85response to acidic pH (GO:0010447)2.87751307
86cell wall macromolecule metabolic process (GO:0044036)2.87206959
87regulation of inclusion body assembly (GO:0090083)2.85709866
88cell wall macromolecule catabolic process (GO:0016998)2.84497867
89DNA methylation involved in gamete generation (GO:0043046)2.80499009
90regulation of acrosome reaction (GO:0060046)2.80145166
91response to phenylpropanoid (GO:0080184)2.79864022
92intraciliary transport (GO:0042073)2.72671689
93regulation of microtubule-based movement (GO:0060632)2.71952776
94negative regulation of heart contraction (GO:0045822)2.70351033
95proximal/distal pattern formation (GO:0009954)2.69346908
96Leydig cell differentiation (GO:0033327)2.68911673
97cranial nerve morphogenesis (GO:0021602)2.65271042
98peptidyl-threonine dephosphorylation (GO:0035970)2.62042613
99sexual reproduction (GO:0019953)2.59012430
100positive regulation of skeletal muscle tissue development (GO:0048643)2.56398792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40738789
2IGF1R_20145208_ChIP-Seq_DFB_Human3.63955363
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60543314
4ZNF274_21170338_ChIP-Seq_K562_Hela2.90302608
5FUS_26573619_Chip-Seq_HEK293_Human2.74354576
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.65919891
7ER_23166858_ChIP-Seq_MCF-7_Human2.60580700
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.56638554
9CBP_20019798_ChIP-Seq_JUKART_Human2.47892203
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.47892203
11GBX2_23144817_ChIP-Seq_PC3_Human2.44174622
12AR_21572438_ChIP-Seq_LNCaP_Human2.36061182
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.35116689
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.23443271
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19279031
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19069852
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.19069852
18VDR_22108803_ChIP-Seq_LS180_Human2.16227913
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.13671904
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00278467
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.98731641
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87311325
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84241180
24P300_19829295_ChIP-Seq_ESCs_Human1.84081468
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.70022004
26AR_25329375_ChIP-Seq_VCAP_Human1.70021305
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68433973
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63311416
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62816097
30* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60946454
31MYC_19829295_ChIP-Seq_ESCs_Human1.60888999
32TP53_18474530_ChIP-ChIP_U2OS_Human1.60294795
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59081264
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.56612076
35SMAD4_21799915_ChIP-Seq_A2780_Human1.54567295
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.54156773
37* RUNX2_22187159_ChIP-Seq_PCA_Human1.53946882
38ETV1_20927104_ChIP-Seq_GIST48_Human1.53260376
39NFYB_21822215_ChIP-Seq_K562_Human1.52814892
40ERA_21632823_ChIP-Seq_H3396_Human1.52552595
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51554281
42TBL1_22424771_ChIP-Seq_293T_Human1.46847731
43NANOG_20526341_ChIP-Seq_ESCs_Human1.46772906
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46010320
45STAT3_23295773_ChIP-Seq_U87_Human1.43998741
46NANOG_19829295_ChIP-Seq_ESCs_Human1.43769261
47SOX2_19829295_ChIP-Seq_ESCs_Human1.43769261
48* RAC3_21632823_ChIP-Seq_H3396_Human1.42322129
49SMAD4_21741376_ChIP-Seq_EPCs_Human1.42118651
50EWS_26573619_Chip-Seq_HEK293_Human1.40971936
51CBX2_22325352_ChIP-Seq_293T-Rex_Human1.40485054
52PHF8_20622853_ChIP-Seq_HELA_Human1.40112504
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38229589
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.37686610
55* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37179089
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32405894
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30705840
58RBPJ_21746931_ChIP-Seq_IB4_Human1.30531615
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.29520388
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.29482353
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.27908149
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26471537
63NFYA_21822215_ChIP-Seq_K562_Human1.26181792
64OCT4_20526341_ChIP-Seq_ESCs_Human1.25917810
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.23125962
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22130810
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.21801954
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.20866792
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20579430
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20220626
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19704029
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18425866
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18305468
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.14922677
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.12572628
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12279424
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10089202
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09273398
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09269275
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09170499
81TCF4_22108803_ChIP-Seq_LS180_Human1.08835467
82OCT1_27270436_Chip-Seq_PROSTATE_Human1.07437272
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05900341
84TCF4_23295773_ChIP-Seq_U87_Human1.04628667
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02924038
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02847076
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01482656
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00330565
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00271965
90SOX9_26525672_Chip-Seq_HEART_Mouse1.00194354
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97387319
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97375579
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97373974
94RXR_22108803_ChIP-Seq_LS180_Human0.96964027
95* ERG_20517297_ChIP-Seq_VCAP_Human0.96754162
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96397759
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.95574384
98* HOXB7_26014856_ChIP-Seq_BT474_Human0.95360294
99CTCF_27219007_Chip-Seq_Bcells_Human0.94459728
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94214116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.98452853
2MP0003698_abnormal_male_reproductive3.44653241
3MP0003878_abnormal_ear_physiology3.41576498
4MP0005377_hearing/vestibular/ear_phenot3.41576498
5MP0002102_abnormal_ear_morphology3.32625094
6MP0001929_abnormal_gametogenesis3.09793548
7MP0001486_abnormal_startle_reflex2.89496118
8MP0005670_abnormal_white_adipose2.39567907
9MP0005394_taste/olfaction_phenotype2.37039449
10MP0005499_abnormal_olfactory_system2.37039449
11MP0002163_abnormal_gland_morphology2.32022565
12MP0000678_abnormal_parathyroid_gland2.28654356
13MP0008995_early_reproductive_senescence2.18152561
14MP0002277_abnormal_respiratory_mucosa2.12402718
15MP0008058_abnormal_DNA_repair2.06572271
16MP0005379_endocrine/exocrine_gland_phen2.03415145
17MP0002234_abnormal_pharynx_morphology2.00929749
18MP0004142_abnormal_muscle_tone1.87089680
19MP0002132_abnormal_respiratory_system1.83977686
20MP0002161_abnormal_fertility/fecundity1.77200107
21MP0002210_abnormal_sex_determination1.75998324
22MP0001968_abnormal_touch/_nociception1.73753304
23MP0009780_abnormal_chondrocyte_physiolo1.67967257
24MP0008877_abnormal_DNA_methylation1.66859938
25MP0003718_maternal_effect1.65649339
26MP0000653_abnormal_sex_gland1.53103110
27MP0005187_abnormal_penis_morphology1.50602364
28MP0001145_abnormal_male_reproductive1.47709210
29MP0004885_abnormal_endolymph1.47576923
30MP0002233_abnormal_nose_morphology1.43357072
31MP0009697_abnormal_copulation1.42999584
32MP0005551_abnormal_eye_electrophysiolog1.41027316
33MP0002638_abnormal_pupillary_reflex1.41007042
34MP0006292_abnormal_olfactory_placode1.39600273
35MP0009745_abnormal_behavioral_response1.37504518
36MP0005248_abnormal_Harderian_gland1.35792306
37MP0004742_abnormal_vestibular_system1.34445049
38MP0000049_abnormal_middle_ear1.33713017
39MP0005360_urolithiasis1.23919423
40MP0002249_abnormal_larynx_morphology1.23806659
41MP0008872_abnormal_physiological_respon1.17478915
42MP0002653_abnormal_ependyma_morphology1.15658870
43MP0002822_catalepsy1.14017303
44MP0005253_abnormal_eye_physiology1.13795291
45MP0001963_abnormal_hearing_physiology1.13504039
46MP0010094_abnormal_chromosome_stability1.12514934
47MP0002272_abnormal_nervous_system1.12270200
48MP0001501_abnormal_sleep_pattern1.12161239
49MP0003635_abnormal_synaptic_transmissio1.10142461
50MP0000026_abnormal_inner_ear1.09654096
51MP0005423_abnormal_somatic_nervous1.03869572
52MP0009046_muscle_twitch1.02773127
53MP0005646_abnormal_pituitary_gland1.02127136
54MP0003045_fibrosis1.02014129
55MP0002557_abnormal_social/conspecific_i0.99876407
56MP0006072_abnormal_retinal_apoptosis0.99337107
57MP0005451_abnormal_body_composition0.97823965
58MP0004145_abnormal_muscle_electrophysio0.97155727
59MP0010307_abnormal_tumor_latency0.97013419
60MP0000631_abnormal_neuroendocrine_gland0.96831871
61MP0001485_abnormal_pinna_reflex0.96792813
62MP0002736_abnormal_nociception_after0.95900294
63MP0002067_abnormal_sensory_capabilities0.94539336
64MP0002572_abnormal_emotion/affect_behav0.92978559
65MP0003868_abnormal_feces_composition0.90890547
66MP0005647_abnormal_sex_gland0.90457740
67MP0002160_abnormal_reproductive_system0.89822087
68MP0005395_other_phenotype0.89482738
69MP0004859_abnormal_synaptic_plasticity0.89376306
70MP0003385_abnormal_body_wall0.89307539
71MP0003950_abnormal_plasma_membrane0.88748483
72MP0002932_abnormal_joint_morphology0.87959198
73MP0001984_abnormal_olfaction0.87460805
74MP0000427_abnormal_hair_cycle0.86191244
75MP0002229_neurodegeneration0.83697668
76MP0000613_abnormal_salivary_gland0.81013524
77MP0003879_abnormal_hair_cell0.80028377
78MP0002063_abnormal_learning/memory/cond0.77838090
79MP0002138_abnormal_hepatobiliary_system0.76220038
80MP0003077_abnormal_cell_cycle0.75983012
81MP0001502_abnormal_circadian_rhythm0.74070173
82MP0002734_abnormal_mechanical_nocicepti0.72600281
83MP0003646_muscle_fatigue0.72100762
84MP0000955_abnormal_spinal_cord0.72071271
85MP0003315_abnormal_perineum_morphology0.71562780
86MP0008569_lethality_at_weaning0.71371354
87MP0002752_abnormal_somatic_nervous0.69618627
88MP0002735_abnormal_chemical_nociception0.66332913
89MP0001764_abnormal_homeostasis0.64593709
90MP0008057_abnormal_DNA_replication0.63587313
91MP0000428_abnormal_craniofacial_morphol0.63394735
92MP0002882_abnormal_neuron_morphology0.62818728
93MP0002282_abnormal_trachea_morphology0.61705993
94MP0002095_abnormal_skin_pigmentation0.60939970
95MP0001119_abnormal_female_reproductive0.60289366
96MP0009115_abnormal_fat_cell0.59553909
97MP0001348_abnormal_lacrimal_gland0.59009240
98MP0000538_abnormal_urinary_bladder0.59006791
99MP0004233_abnormal_muscle_weight0.58130825
100MP0003787_abnormal_imprinting0.57885587

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.59655381
2Absent/shortened dynein arms (HP:0200106)4.49262140
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.49262140
4Abnormal ciliary motility (HP:0012262)3.71623689
5Abnormal sex determination (HP:0012244)3.65529708
6Sex reversal (HP:0012245)3.65529708
7Abnormality of the pubic bones (HP:0003172)3.65184545
8Abnormal respiratory motile cilium physiology (HP:0012261)3.60554971
9Bell-shaped thorax (HP:0001591)3.52941601
10Rhabdomyosarcoma (HP:0002859)3.52842279
11Abnormal rod and cone electroretinograms (HP:0008323)3.52191499
12Tubulointerstitial nephritis (HP:0001970)3.51122419
13Resting tremor (HP:0002322)3.44006567
14Attenuation of retinal blood vessels (HP:0007843)3.42088701
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34129074
16Medulloblastoma (HP:0002885)3.29287455
17Type II lissencephaly (HP:0007260)3.26885707
18Renal dysplasia (HP:0000110)3.24939647
19Occipital encephalocele (HP:0002085)3.20770397
20Abnormal respiratory epithelium morphology (HP:0012253)3.20608556
21Abnormal respiratory motile cilium morphology (HP:0005938)3.20608556
22Bony spicule pigmentary retinopathy (HP:0007737)3.01865779
23Neoplasm of striated muscle (HP:0009728)2.87556097
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.84309548
25Abnormality of macular pigmentation (HP:0008002)2.84044633
26Neoplasm of the oral cavity (HP:0100649)2.80884381
27Gonadal dysgenesis (HP:0000133)2.80852445
28Glioma (HP:0009733)2.77394257
29Abnormality of chromosome stability (HP:0003220)2.61053416
30Azoospermia (HP:0000027)2.60991627
31Atonic seizures (HP:0010819)2.60679052
32Focal motor seizures (HP:0011153)2.59851702
33Impulsivity (HP:0100710)2.54305615
34Abnormality of DNA repair (HP:0003254)2.54013577
35Papillary thyroid carcinoma (HP:0002895)2.53904158
36Cerebellar dysplasia (HP:0007033)2.53132078
37Acanthocytosis (HP:0001927)2.52845253
38Aplasia/Hypoplasia of the earlobes (HP:0009906)2.50097859
39Nephronophthisis (HP:0000090)2.39551993
40Poor eye contact (HP:0000817)2.38910384
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37308174
42Hepatoblastoma (HP:0002884)2.36817581
43Chronic hepatic failure (HP:0100626)2.36641199
44Unilateral renal agenesis (HP:0000122)2.36621328
45Neoplasm of the adrenal cortex (HP:0100641)2.34407352
46Retinal dysplasia (HP:0007973)2.33439121
47Hypoplasia of the uterus (HP:0000013)2.30241574
48Infertility (HP:0000789)2.29662229
49Astrocytoma (HP:0009592)2.26707209
50Abnormality of the astrocytes (HP:0100707)2.26707209
51Aplasia/Hypoplasia of the scapulae (HP:0006713)2.23670343
52Hypoplastic scapulae (HP:0000882)2.23670343
53Chromsome breakage (HP:0040012)2.17689472
54Short middle phalanx of the 5th finger (HP:0004220)2.11628287
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11214066
56Small intestinal stenosis (HP:0012848)2.10767177
57Duodenal stenosis (HP:0100867)2.10767177
58Ectopic kidney (HP:0000086)2.10287165
59Meckel diverticulum (HP:0002245)2.09600252
60Abnormality of the ileum (HP:0001549)2.09267396
61Adrenal hypoplasia (HP:0000835)2.08552949
62Male pseudohermaphroditism (HP:0000037)2.07104117
63Sloping forehead (HP:0000340)2.06547779
64Stomach cancer (HP:0012126)2.06009828
65Abnormality of the costochondral junction (HP:0000919)2.05428263
66Chin dimple (HP:0010751)2.05362055
67Abnormality of the renal medulla (HP:0100957)2.04901775
68Enlarged epiphyses (HP:0010580)2.02653827
69Hyperkalemia (HP:0002153)2.01364584
70Rhinitis (HP:0012384)1.98615981
71Hyperthyroidism (HP:0000836)1.97118555
72Abnormal spermatogenesis (HP:0008669)1.96214090
73Protruding tongue (HP:0010808)1.95888301
74Optic nerve hypoplasia (HP:0000609)1.95244402
75Nasal polyposis (HP:0100582)1.94091059
76Colon cancer (HP:0003003)1.94061480
77Periauricular skin pits (HP:0100277)1.93039677
78Preauricular pit (HP:0004467)1.93039677
79True hermaphroditism (HP:0010459)1.91333837
80Neoplasm of the small intestine (HP:0100833)1.90919738
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90031660
82Abnormality of B cell number (HP:0010975)1.89239349
83Midline defect of the nose (HP:0004122)1.89086158
84B lymphocytopenia (HP:0010976)1.88209440
85Abnormality of the ischium (HP:0003174)1.84595691
86Aplasia/hypoplasia of the uterus (HP:0008684)1.80067386
87Recurrent pneumonia (HP:0006532)1.78537080
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78275176
89Poikilocytosis (HP:0004447)1.75724116
90Bronchiectasis (HP:0002110)1.74325955
91Postural instability (HP:0002172)1.71807948
92Anencephaly (HP:0002323)1.71014090
93Retinal atrophy (HP:0001105)1.70357906
94Hypoplastic ischia (HP:0003175)1.70236286
95Inability to walk (HP:0002540)1.69753174
96Epidermoid cyst (HP:0200040)1.69716188
97Postaxial foot polydactyly (HP:0001830)1.68659538
98Clubbing of toes (HP:0100760)1.67837147
99Febrile seizures (HP:0002373)1.67780974
100Abnormality of the preputium (HP:0100587)1.67261307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.87266223
2PINK14.78220664
3PNCK3.04295970
4MARK32.59527827
5CCNB12.53771077
6FRK2.40880385
7NTRK32.31873595
8DDR22.30814642
9MAP4K22.30302937
10STK38L2.27581149
11CSNK1A1L2.12716909
12INSRR2.10512965
13TAOK32.09590899
14NME12.08227049
15CSNK1G31.95068705
16CAMK1G1.92785283
17BMPR1B1.92365452
18BCR1.79817367
19MAPK151.78481436
20ZAK1.75374583
21CSNK1G11.63434038
22PLK21.60217050
23NUAK11.54542746
24RPS6KA51.53629093
25BRD41.44185244
26PTK2B1.41190257
27CSNK1G21.40674720
28PKN11.37719886
29TEC1.34638144
30CAMK1D1.29215922
31TLK11.29060653
32STK381.27020826
33MAPK131.25926966
34STK241.22555127
35PRKD31.15508970
36VRK11.13738680
37CAMK11.09828164
38MARK11.09353489
39LATS11.04857268
40CASK1.04669459
41ACVR1B1.03892220
42BMPR21.03263797
43DYRK21.00019234
44CDK30.96837425
45WNK30.93150270
46CLK10.92666968
47DAPK20.89240541
48NEK20.88793763
49ATM0.85951639
50MAP3K70.80250965
51CDC70.79353931
52MAP2K70.72975570
53MINK10.72181643
54DYRK30.71563565
55TTK0.71443913
56TESK10.71268172
57TNIK0.69688910
58MAP3K20.69487696
59EIF2AK30.68132635
60MKNK20.65540772
61RIPK40.63186699
62WNK40.62929375
63DYRK1A0.57264489
64WEE10.57261952
65MAP3K130.56865461
66CAMK40.55868635
67ROCK10.54753281
68MYLK0.54596598
69ATR0.54376648
70PRKCQ0.54264069
71PRKG10.52423459
72RAF10.51864992
73EPHA40.51602772
74CSNK1A10.51261471
75STK30.48628301
76GSK3B0.45849631
77KSR20.45561408
78SRPK10.44340317
79CHEK20.43555519
80PDK10.42846593
81CDK10.41606889
82CDK20.40697359
83MAP3K40.39468126
84MAPK10.39211521
85NEK60.39104685
86CSNK1D0.38422478
87PRKAA10.37892918
88DYRK1B0.36848343
89BRSK20.34446009
90PDPK10.32864647
91CHEK10.32760407
92MAP2K10.31268367
93CAMKK20.30819464
94SGK10.29755881
95RPS6KA10.29454556
96MAP2K60.26768522
97PLK10.26478692
98CDK50.24836119
99DMPK0.23542988
100MAPK80.23234302

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.08570258
2Olfactory transduction_Homo sapiens_hsa047404.15616672
3Fatty acid biosynthesis_Homo sapiens_hsa000613.59516149
4Butanoate metabolism_Homo sapiens_hsa006502.92106951
5Homologous recombination_Homo sapiens_hsa034402.51058106
6Fanconi anemia pathway_Homo sapiens_hsa034602.51034675
7Systemic lupus erythematosus_Homo sapiens_hsa053222.27060119
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.24245765
9Dorso-ventral axis formation_Homo sapiens_hsa043202.11377342
10Basal transcription factors_Homo sapiens_hsa030222.07765569
11Propanoate metabolism_Homo sapiens_hsa006402.05889178
12Nitrogen metabolism_Homo sapiens_hsa009101.90526930
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83792375
14Gap junction_Homo sapiens_hsa045401.75813556
15Alcoholism_Homo sapiens_hsa050341.74909512
16RNA transport_Homo sapiens_hsa030131.72581136
17Hedgehog signaling pathway_Homo sapiens_hsa043401.67311814
18Salivary secretion_Homo sapiens_hsa049701.59251562
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.55303397
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54599446
21Fatty acid metabolism_Homo sapiens_hsa012121.49426256
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47098101
23Taste transduction_Homo sapiens_hsa047421.39124443
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.34029963
25Nicotine addiction_Homo sapiens_hsa050331.32946445
26One carbon pool by folate_Homo sapiens_hsa006701.27490292
27Selenocompound metabolism_Homo sapiens_hsa004501.23042784
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21114983
29Allograft rejection_Homo sapiens_hsa053301.18624920
30mRNA surveillance pathway_Homo sapiens_hsa030151.14063192
31Oocyte meiosis_Homo sapiens_hsa041141.13537767
32Autoimmune thyroid disease_Homo sapiens_hsa053201.10879340
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08421671
34RNA degradation_Homo sapiens_hsa030181.03088148
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01972652
36Calcium signaling pathway_Homo sapiens_hsa040201.00207401
37Arginine biosynthesis_Homo sapiens_hsa002200.98783057
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98147724
39Fatty acid degradation_Homo sapiens_hsa000710.97596918
40Graft-versus-host disease_Homo sapiens_hsa053320.97507560
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97376206
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93997784
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93712225
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93242668
45Nucleotide excision repair_Homo sapiens_hsa034200.91369678
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.90747791
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88328568
48Steroid biosynthesis_Homo sapiens_hsa001000.87056699
49Mismatch repair_Homo sapiens_hsa034300.84181167
50Arginine and proline metabolism_Homo sapiens_hsa003300.83918199
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.83201751
52Type I diabetes mellitus_Homo sapiens_hsa049400.81629849
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79609764
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79299303
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77736757
56Viral myocarditis_Homo sapiens_hsa054160.75800360
57Morphine addiction_Homo sapiens_hsa050320.75324065
58Synaptic vesicle cycle_Homo sapiens_hsa047210.73600287
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73498770
60GABAergic synapse_Homo sapiens_hsa047270.70336735
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.69288059
62DNA replication_Homo sapiens_hsa030300.66151794
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64085607
64Asthma_Homo sapiens_hsa053100.64006187
65Apoptosis_Homo sapiens_hsa042100.61995115
66Phototransduction_Homo sapiens_hsa047440.59031334
67Purine metabolism_Homo sapiens_hsa002300.57861775
68Glutamatergic synapse_Homo sapiens_hsa047240.55896037
69Phagosome_Homo sapiens_hsa041450.55685512
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55488382
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55208825
72Spliceosome_Homo sapiens_hsa030400.54625843
73beta-Alanine metabolism_Homo sapiens_hsa004100.52525734
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.52076222
75Renin secretion_Homo sapiens_hsa049240.49053918
76Viral carcinogenesis_Homo sapiens_hsa052030.47490551
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.47447319
78Lysine degradation_Homo sapiens_hsa003100.47204338
79Oxytocin signaling pathway_Homo sapiens_hsa049210.46316605
80ABC transporters_Homo sapiens_hsa020100.45771588
81Herpes simplex infection_Homo sapiens_hsa051680.44581885
82Cardiac muscle contraction_Homo sapiens_hsa042600.44443482
83Protein digestion and absorption_Homo sapiens_hsa049740.42950951
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.42943036
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42442466
86Regulation of autophagy_Homo sapiens_hsa041400.41981344
87Type II diabetes mellitus_Homo sapiens_hsa049300.40931409
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40357455
89Circadian entrainment_Homo sapiens_hsa047130.39113365
90PPAR signaling pathway_Homo sapiens_hsa033200.38938714
91Mineral absorption_Homo sapiens_hsa049780.38928955
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38779170
93Pyruvate metabolism_Homo sapiens_hsa006200.38752999
94Glycerolipid metabolism_Homo sapiens_hsa005610.37548983
95Non-homologous end-joining_Homo sapiens_hsa034500.36865964
96Retinol metabolism_Homo sapiens_hsa008300.36676407
97Base excision repair_Homo sapiens_hsa034100.35658900
98Tryptophan metabolism_Homo sapiens_hsa003800.35605926
99Antigen processing and presentation_Homo sapiens_hsa046120.32605183
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30167696

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