ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.27843249
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.94037015
3	regulation of cilium movement (GO:0003352)	4.17629135
4	nonmotile primary cilium assembly (GO:0035058)	4.05759939
5	epithelial cilium movement (GO:0003351)	4.03343553
6	pyrimidine nucleobase catabolic process (GO:0006208)	3.72043593
7	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.56449783
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.49225778
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.42487096
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41953773
11	NADH dehydrogenase complex assembly (GO:0010257)	3.41953773
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41953773
13	response to pheromone (GO:0019236)	3.40828722
14	DNA deamination (GO:0045006)	3.39878797
15	cellular ketone body metabolic process (GO:0046950)	3.38381784
16	protein complex biogenesis (GO:0070271)	3.27915085
17	postsynaptic membrane organization (GO:0001941)	3.26653505
18	establishment of mitochondrion localization (GO:0051654)	3.26547364
19	gamma-aminobutyric acid transport (GO:0015812)	3.24270780
20	ubiquinone biosynthetic process (GO:0006744)	3.23242642
21	cilium movement (GO:0003341)	3.23113912
22	regulation of microtubule-based movement (GO:0060632)	3.22880191
23	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.15330760
24	neuronal action potential propagation (GO:0019227)	3.12736890
25	C4-dicarboxylate transport (GO:0015740)	3.11801347
26	presynaptic membrane assembly (GO:0097105)	3.09834073
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09659679
28	ketone body metabolic process (GO:1902224)	3.07989080
29	nucleobase catabolic process (GO:0046113)	3.06032997
30	presynaptic membrane organization (GO:0097090)	3.04804276
31	ubiquinone metabolic process (GO:0006743)	3.04259472
32	neuron cell-cell adhesion (GO:0007158)	3.01619064
33	short-term memory (GO:0007614)	2.99759654
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.96541794
35	protein polyglutamylation (GO:0018095)	2.95082269
36	fucose catabolic process (GO:0019317)	2.94353769
37	L-fucose metabolic process (GO:0042354)	2.94353769
38	L-fucose catabolic process (GO:0042355)	2.94353769
39	sequestering of actin monomers (GO:0042989)	2.90418140
40	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.90250150
41	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.90250150
42	cilium morphogenesis (GO:0060271)	2.87241533
43	mitochondrion transport along microtubule (GO:0047497)	2.87237598
44	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.87237598
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84916595
46	mannosylation (GO:0097502)	2.84091717
47	proline transport (GO:0015824)	2.83684383
48	behavioral response to ethanol (GO:0048149)	2.83002936
49	transmission of nerve impulse (GO:0019226)	2.82701702
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80690084
51	indolalkylamine metabolic process (GO:0006586)	2.76245315
52	ATP synthesis coupled proton transport (GO:0015986)	2.74475533
53	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74475533
54	negative regulation of telomere maintenance (GO:0032205)	2.73403875
55	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72918135
56	neuronal action potential (GO:0019228)	2.72903949
57	auditory receptor cell stereocilium organization (GO:0060088)	2.66244422
58	inner ear receptor stereocilium organization (GO:0060122)	2.65036758
59	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.64960156
60	startle response (GO:0001964)	2.63115019
61	cilium organization (GO:0044782)	2.62873258
62	cilium assembly (GO:0042384)	2.62304546
63	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.60486080
64	amino acid salvage (GO:0043102)	2.60052973
65	L-methionine salvage (GO:0071267)	2.60052973
66	L-methionine biosynthetic process (GO:0071265)	2.60052973
67	respiratory chain complex IV assembly (GO:0008535)	2.58861570
68	somite rostral/caudal axis specification (GO:0032525)	2.56813117
69	axonemal dynein complex assembly (GO:0070286)	2.56760716
70	positive regulation of mitochondrial fission (GO:0090141)	2.55787988
71	protein neddylation (GO:0045116)	2.54849877
72	reflex (GO:0060004)	2.53477811
73	serotonin metabolic process (GO:0042428)	2.51244096
74	DNA double-strand break processing (GO:0000729)	2.50672064
75	piRNA metabolic process (GO:0034587)	2.50630915
76	axoneme assembly (GO:0035082)	2.50512676
77	quinone biosynthetic process (GO:1901663)	2.50054743
78	urinary tract smooth muscle contraction (GO:0014848)	2.49936894
79	membrane depolarization during action potential (GO:0086010)	2.48561209
80	glycosphingolipid biosynthetic process (GO:0006688)	2.48267801
81	photoreceptor cell maintenance (GO:0045494)	2.48242567
82	serotonin receptor signaling pathway (GO:0007210)	2.48054677
83	positive regulation of guanylate cyclase activity (GO:0031284)	2.47797700
84	regulation of timing of cell differentiation (GO:0048505)	2.46652785
85	primary amino compound metabolic process (GO:1901160)	2.46153996
86	synaptic transmission, cholinergic (GO:0007271)	2.45768854
87	indole-containing compound metabolic process (GO:0042430)	2.45611885
88	kynurenine metabolic process (GO:0070189)	2.44704982
89	hindbrain development (GO:0030902)	2.44444889
90	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.44139689
91	mechanosensory behavior (GO:0007638)	2.42568235
92	sulfation (GO:0051923)	2.41995416
93	neuromuscular synaptic transmission (GO:0007274)	2.40768311
94	ovulation cycle (GO:0042698)	2.40296519
95	DNA methylation involved in gamete generation (GO:0043046)	2.40025142
96	neural tube formation (GO:0001841)	2.39476197
97	cytochrome complex assembly (GO:0017004)	2.38421193
98	protein-cofactor linkage (GO:0018065)	2.38351806
99	glutamate receptor signaling pathway (GO:0007215)	2.37825156
100	cilium or flagellum-dependent cell motility (GO:0001539)	2.37448837

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.15385671
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.96971380
3	VDR_22108803_ChIP-Seq_LS180_Human	3.67458321
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.53340746
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93901921
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59828271
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55161763
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50458516
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25126108
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.25096848
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16897722
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08587301
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.08560011
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.08321210
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05521104
16	P300_19829295_ChIP-Seq_ESCs_Human	1.96613877
17	EWS_26573619_Chip-Seq_HEK293_Human	1.93356058
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84662828
19	FUS_26573619_Chip-Seq_HEK293_Human	1.83600047
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.79720544
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78846283
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.74063583
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68583228
24	REST_21632747_ChIP-Seq_MESCs_Mouse	1.64401740
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61524577
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57509848
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57006708
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.56947834
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54242148
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53951054
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53779945
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52687528
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50934223
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49811513
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49606390
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48629308
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48183040
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46421425
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.46421425
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44241936
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.41432985
42	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.41108966
43	STAT3_23295773_ChIP-Seq_U87_Human	1.40081384
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39981664
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.39860412
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.39762941
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38688915
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38193391
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.38036339
50	AR_25329375_ChIP-Seq_VCAP_Human	1.37795163
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37637586
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37637586
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37540413
54	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35486978
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34119762
56	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32272090
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29456894
58	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29096274
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29052639
60	TCF4_23295773_ChIP-Seq_U87_Human	1.28778848
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28304452
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25730170
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25266534
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24426755
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22474614
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21768897
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21768897
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20113033
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19961080
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16657355
71	AR_21572438_ChIP-Seq_LNCaP_Human	1.13619672
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13146725
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11880187
74	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11647655
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11305819
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10176113
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09998986
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.09180928
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.08746069
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08255678
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07872095
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07326817
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07326817
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05980205
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04324390
86	NCOR_22424771_ChIP-Seq_293T_Human	1.01214108
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00935216
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00546545
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00183363
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99946591
91	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99877021
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99215571
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97118963
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96216030
95	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.94965270
96	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.94895541
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94758530
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94038500
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93606070
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92430900

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.11177515
2	MP0008877_abnormal_DNA_methylation	2.80003970
3	MP0002102_abnormal_ear_morphology	2.71366776
4	MP0009046_muscle_twitch	2.65214433
5	MP0001968_abnormal_touch/_nociception	2.59649533
6	MP0000569_abnormal_digit_pigmentation	2.52102145
7	MP0002736_abnormal_nociception_after	2.35432064
8	MP0004133_heterotaxia	2.31800582
9	MP0006276_abnormal_autonomic_nervous	2.31677621
10	MP0003787_abnormal_imprinting	2.17699449
11	MP0004742_abnormal_vestibular_system	2.16919578
12	MP0002272_abnormal_nervous_system	2.09111296
13	MP0002735_abnormal_chemical_nociception	2.04245564
14	MP0009745_abnormal_behavioral_response	2.03367410
15	MP0005551_abnormal_eye_electrophysiolog	1.95277140
16	MP0002938_white_spotting	1.94699067
17	MP0001984_abnormal_olfaction	1.93962798
18	MP0004859_abnormal_synaptic_plasticity	1.93947534
19	MP0006292_abnormal_olfactory_placode	1.91291748
20	MP0001486_abnormal_startle_reflex	1.90750352
21	MP0004885_abnormal_endolymph	1.89681580
22	MP0001529_abnormal_vocalization	1.75737448
23	MP0003635_abnormal_synaptic_transmissio	1.75011959
24	MP0003122_maternal_imprinting	1.74429522
25	MP0002572_abnormal_emotion/affect_behav	1.73028952
26	MP0004142_abnormal_muscle_tone	1.70469950
27	MP0001986_abnormal_taste_sensitivity	1.68662617
28	MP0003646_muscle_fatigue	1.67245672
29	MP0002064_seizures	1.66207621
30	MP0008872_abnormal_physiological_respon	1.62613791
31	MP0001501_abnormal_sleep_pattern	1.60972414
32	MP0005645_abnormal_hypothalamus_physiol	1.58445086
33	MP0002067_abnormal_sensory_capabilities	1.58124677
34	MP0001905_abnormal_dopamine_level	1.57102131
35	MP0008789_abnormal_olfactory_epithelium	1.56684090
36	MP0003195_calcinosis	1.54167096
37	MP0002557_abnormal_social/conspecific_i	1.54034813
38	MP0005394_taste/olfaction_phenotype	1.53851372
39	MP0005499_abnormal_olfactory_system	1.53851372
40	MP0002063_abnormal_learning/memory/cond	1.53171331
41	MP0001485_abnormal_pinna_reflex	1.53114512
42	MP0005646_abnormal_pituitary_gland	1.52488240
43	MP0008875_abnormal_xenobiotic_pharmacok	1.50382838
44	MP0002638_abnormal_pupillary_reflex	1.50360050
45	MP0004147_increased_porphyrin_level	1.49678377
46	MP0000566_synostosis	1.49439392
47	MP0003718_maternal_effect	1.49229608
48	MP0005187_abnormal_penis_morphology	1.48807322
49	MP0000778_abnormal_nervous_system	1.45222330
50	MP0002733_abnormal_thermal_nociception	1.44594202
51	MP0004145_abnormal_muscle_electrophysio	1.44407971
52	MP0001970_abnormal_pain_threshold	1.39910576
53	MP0000372_irregular_coat_pigmentation	1.38615952
54	MP0002734_abnormal_mechanical_nocicepti	1.38016710
55	MP0006072_abnormal_retinal_apoptosis	1.37616880
56	MP0005084_abnormal_gallbladder_morpholo	1.34690124
57	MP0002234_abnormal_pharynx_morphology	1.31979914
58	MP0002653_abnormal_ependyma_morphology	1.25832981
59	MP0003121_genomic_imprinting	1.25712064
60	MP0005253_abnormal_eye_physiology	1.24454306
61	MP0002837_dystrophic_cardiac_calcinosis	1.18697989
62	MP0004924_abnormal_behavior	1.18469058
63	MP0005386_behavior/neurological_phenoty	1.18469058
64	MP0000427_abnormal_hair_cycle	1.17148982
65	MP0002751_abnormal_autonomic_nervous	1.13317346
66	MP0002184_abnormal_innervation	1.11871125
67	MP0008995_early_reproductive_senescence	1.11454685
68	MP0000049_abnormal_middle_ear	1.11225870
69	MP0005423_abnormal_somatic_nervous	1.09265829
70	MP0003119_abnormal_digestive_system	1.09141140
71	MP0002752_abnormal_somatic_nervous	1.07941520
72	MP0003136_yellow_coat_color	1.06958340
73	MP0003315_abnormal_perineum_morphology	1.05859523
74	MP0000631_abnormal_neuroendocrine_gland	1.05360131
75	MP0008058_abnormal_DNA_repair	1.04959628
76	MP0000026_abnormal_inner_ear	1.03997545
77	MP0004043_abnormal_pH_regulation	1.02848982
78	MP0010386_abnormal_urinary_bladder	1.00714770
79	MP0001440_abnormal_grooming_behavior	0.96100588
80	MP0002882_abnormal_neuron_morphology	0.95532881
81	MP0003890_abnormal_embryonic-extraembry	0.94411141
82	MP0000955_abnormal_spinal_cord	0.90466509
83	MP0005167_abnormal_blood-brain_barrier	0.89669115
84	MP0001963_abnormal_hearing_physiology	0.88010794
85	MP0005195_abnormal_posterior_eye	0.86450963
86	MP0003698_abnormal_male_reproductive	0.85654300
87	MP0002066_abnormal_motor_capabilities/c	0.85584442
88	MP0002822_catalepsy	0.85391844
89	MP0005410_abnormal_fertilization	0.83927624
90	MP0004270_analgesia	0.83849578
91	MP0003937_abnormal_limbs/digits/tail_de	0.82324894
92	MP0002229_neurodegeneration	0.81519102
93	MP0000230_abnormal_systemic_arterial	0.80539277
94	MP0000383_abnormal_hair_follicle	0.79198820
95	MP0003567_abnormal_fetal_cardiomyocyte	0.76437678
96	MP0004215_abnormal_myocardial_fiber	0.74147527
97	MP0001929_abnormal_gametogenesis	0.73632844
98	MP0002210_abnormal_sex_determination	0.73319870
99	MP0005174_abnormal_tail_pigmentation	0.71851738
100	MP0001293_anophthalmia	0.71709941

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.11584911
2	True hermaphroditism (HP:0010459)	4.05456047
3	Pancreatic cysts (HP:0001737)	4.03439251
4	Abnormality of midbrain morphology (HP:0002418)	3.77278369
5	Molar tooth sign on MRI (HP:0002419)	3.77278369
6	Hyperventilation (HP:0002883)	3.74950633
7	Nephronophthisis (HP:0000090)	3.60647742
8	Type II lissencephaly (HP:0007260)	3.49699210
9	Medial flaring of the eyebrow (HP:0010747)	3.30441009
10	Gait imbalance (HP:0002141)	3.23147230
11	Methylmalonic acidemia (HP:0002912)	3.09212762
12	Focal motor seizures (HP:0011153)	3.07552618
13	Congenital primary aphakia (HP:0007707)	3.03203334
14	Inability to walk (HP:0002540)	2.91440265
15	Congenital stationary night blindness (HP:0007642)	2.88503135
16	Abnormality of the renal medulla (HP:0100957)	2.83701329
17	Increased hepatocellular lipid droplets (HP:0006565)	2.79291152
18	Methylmalonic aciduria (HP:0012120)	2.70415938
19	Nephrogenic diabetes insipidus (HP:0009806)	2.70090502
20	Lissencephaly (HP:0001339)	2.64333705
21	Abnormality of the renal cortex (HP:0011035)	2.63112280
22	Lipid accumulation in hepatocytes (HP:0006561)	2.62906335
23	Abnormal ciliary motility (HP:0012262)	2.60516443
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.58793904
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.58793904
26	Retinal dysplasia (HP:0007973)	2.58619434
27	Renal cortical cysts (HP:0000803)	2.57077568
28	Genital tract atresia (HP:0001827)	2.56192426
29	Colon cancer (HP:0003003)	2.50927450
30	Limb dystonia (HP:0002451)	2.50377802
31	Acute necrotizing encephalopathy (HP:0006965)	2.49591745
32	Cystic liver disease (HP:0006706)	2.47919512
33	Abnormality of the labia minora (HP:0012880)	2.45965588
34	Progressive inability to walk (HP:0002505)	2.45678759
35	Cerebellar dysplasia (HP:0007033)	2.44676478
36	Vaginal atresia (HP:0000148)	2.43464494
37	Absent/shortened dynein arms (HP:0200106)	2.42463630
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42463630
39	Mitochondrial inheritance (HP:0001427)	2.41652095
40	Birth length less than 3rd percentile (HP:0003561)	2.40042210
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.39641752
42	Optic nerve hypoplasia (HP:0000609)	2.37208991
43	Polyphagia (HP:0002591)	2.36469988
44	Sclerocornea (HP:0000647)	2.35046886
45	Renal Fanconi syndrome (HP:0001994)	2.33517669
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.32211400
47	Poor coordination (HP:0002370)	2.28776910
48	Pachygyria (HP:0001302)	2.27536763
49	Absent speech (HP:0001344)	2.26641350
50	Increased CSF lactate (HP:0002490)	2.26472131
51	Concave nail (HP:0001598)	2.25848501
52	Anencephaly (HP:0002323)	2.24813481
53	Acute encephalopathy (HP:0006846)	2.23847110
54	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20665663
55	Decreased central vision (HP:0007663)	2.17307833
56	Chronic hepatic failure (HP:0100626)	2.17070637
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.16824793
58	Progressive macrocephaly (HP:0004481)	2.16763698
59	Progressive cerebellar ataxia (HP:0002073)	2.12902291
60	Broad-based gait (HP:0002136)	2.08610712
61	Abnormal number of erythroid precursors (HP:0012131)	2.07746637
62	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07517882
63	Male pseudohermaphroditism (HP:0000037)	2.03957010
64	Postaxial foot polydactyly (HP:0001830)	2.02526962
65	Patellar aplasia (HP:0006443)	2.02516649
66	Abnormal rod and cone electroretinograms (HP:0008323)	2.01840668
67	Rib fusion (HP:0000902)	2.00995074
68	Hemiparesis (HP:0001269)	2.00545379
69	Occipital encephalocele (HP:0002085)	1.98731330
70	Large for gestational age (HP:0001520)	1.98620545
71	Pendular nystagmus (HP:0012043)	1.97869802
72	Congenital hepatic fibrosis (HP:0002612)	1.96656904
73	Febrile seizures (HP:0002373)	1.95179548
74	Atonic seizures (HP:0010819)	1.93005984
75	Focal seizures (HP:0007359)	1.92775360
76	Aplasia/Hypoplasia of the patella (HP:0006498)	1.92002133
77	Genetic anticipation (HP:0003743)	1.86737533
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85986556
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.84494187
80	Severe muscular hypotonia (HP:0006829)	1.84063156
81	Hypothermia (HP:0002045)	1.82182972
82	Congenital sensorineural hearing impairment (HP:0008527)	1.81725580
83	Epileptic encephalopathy (HP:0200134)	1.81590830
84	Increased corneal curvature (HP:0100692)	1.81316737
85	Keratoconus (HP:0000563)	1.81316737
86	Polydipsia (HP:0001959)	1.80926115
87	Abnormal drinking behavior (HP:0030082)	1.80926115
88	Furrowed tongue (HP:0000221)	1.80743844
89	Postaxial hand polydactyly (HP:0001162)	1.80313564
90	Attenuation of retinal blood vessels (HP:0007843)	1.79815173
91	Hepatocellular necrosis (HP:0001404)	1.79552034
92	Congenital, generalized hypertrichosis (HP:0004540)	1.78420703
93	Abnormality of renal resorption (HP:0011038)	1.76671194
94	Narrow forehead (HP:0000341)	1.75837490
95	Hyperglycinemia (HP:0002154)	1.75381077
96	Abnormality of vitamin B metabolism (HP:0004340)	1.74899720
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.74084777
98	Rhinitis (HP:0012384)	1.74042940
99	Abolished electroretinogram (ERG) (HP:0000550)	1.73919840
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.73783762

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	3.33113408
2	CASK	3.08627875
3	WNK3	2.93415664
4	MAPK13	2.92260780
5	FRK	2.91974187
6	MAP3K4	2.59568116
7	MARK1	2.41040231
8	BMPR1B	2.25322420
9	MAP4K2	2.24572328
10	ADRBK2	2.16520065
11	PINK1	1.97598529
12	NUAK1	1.90008722
13	MAP2K7	1.87149581
14	GRK1	1.84794837
15	TLK1	1.75583793
16	DYRK2	1.75380377
17	VRK2	1.72273362
18	NTRK3	1.71763000
19	MAPKAPK5	1.69655882
20	PNCK	1.65199482
21	ZAK	1.61797663
22	TAF1	1.59625950
23	NTRK2	1.57730772
24	TNIK	1.57066148
25	BRSK2	1.55278310
26	INSRR	1.53649272
27	TAOK3	1.53319692
28	WNK4	1.48424619
29	VRK1	1.46311423
30	EPHA4	1.45575402
31	CSNK1G2	1.43527837
32	ACVR1B	1.41491169
33	DAPK2	1.39362475
34	PLK4	1.31895030
35	PRKCG	1.24869641
36	PAK3	1.22123465
37	PTK2B	1.12870420
38	CSNK1G3	1.11570678
39	NEK2	1.09022133
40	CSNK1G1	1.08519646
41	MAP2K4	1.07139213
42	TSSK6	1.00593329
43	OXSR1	0.98030565
44	PBK	0.95337752
45	CAMKK2	0.92359148
46	PLK2	0.91588304
47	TGFBR1	0.90431291
48	MAP3K12	0.90248990
49	TXK	0.90082312
50	PKN1	0.89497145
51	CSNK1A1L	0.88279962
52	BCKDK	0.87075076
53	MINK1	0.86417752
54	MKNK2	0.82836620
55	MAPK15	0.80025300
56	NME1	0.78927193
57	WEE1	0.78339187
58	MAPKAPK3	0.76223299
59	ADRBK1	0.74374602
60	MST4	0.72556912
61	PLK3	0.71568690
62	CAMK2A	0.71134807
63	PHKG2	0.66484606
64	PHKG1	0.66484606
65	GRK5	0.66237133
66	FGFR2	0.63729795
67	DYRK3	0.62481818
68	PRKCE	0.62255939
69	BCR	0.60084407
70	CAMK2B	0.59365473
71	CCNB1	0.58264578
72	TIE1	0.56862707
73	MKNK1	0.56018848
74	STK39	0.54927550
75	LIMK1	0.53708141
76	CDK8	0.53236413
77	DYRK1A	0.51571867
78	RPS6KA5	0.50564898
79	PAK6	0.49560644
80	PRKACB	0.48378480
81	TRIM28	0.48211472
82	CSNK1A1	0.46421172
83	PRKACA	0.46338069
84	PLK1	0.46082081
85	CAMK1	0.45823387
86	CAMK1G	0.42451553
87	CAMK2D	0.40045173
88	UHMK1	0.39058032
89	CHEK2	0.38501993
90	STK16	0.37127286
91	PRKG1	0.35716936
92	BUB1	0.35704130
93	CDC7	0.35159829
94	CDK5	0.34639758
95	PRKCQ	0.34483424
96	SIK2	0.32062579
97	PIK3CA	0.30698921
98	CAMK4	0.30617933
99	CAMK1D	0.29492729
100	DAPK1	0.29465405

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.09179740
2	Nicotine addiction_Homo sapiens_hsa05033	3.05068817
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.81745526
4	Phototransduction_Homo sapiens_hsa04744	2.59146055
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.50331144
6	Parkinsons disease_Homo sapiens_hsa05012	2.44449702
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43590204
8	Butanoate metabolism_Homo sapiens_hsa00650	2.39014427
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.05181735
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90398839
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90397165
12	Taste transduction_Homo sapiens_hsa04742	1.76138554
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.75927588
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.75168087
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73294289
16	Protein export_Homo sapiens_hsa03060	1.70152570
17	RNA polymerase_Homo sapiens_hsa03020	1.63242120
18	Huntingtons disease_Homo sapiens_hsa05016	1.60483573
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53969112
20	Morphine addiction_Homo sapiens_hsa05032	1.51022217
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49936303
22	GABAergic synapse_Homo sapiens_hsa04727	1.45809065
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43556137
24	Basal transcription factors_Homo sapiens_hsa03022	1.41831110
25	Homologous recombination_Homo sapiens_hsa03440	1.41705549
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.41439136
27	Caffeine metabolism_Homo sapiens_hsa00232	1.39514195
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.39095111
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.38997294
30	Regulation of autophagy_Homo sapiens_hsa04140	1.37981581
31	Alzheimers disease_Homo sapiens_hsa05010	1.37752862
32	Peroxisome_Homo sapiens_hsa04146	1.35448289
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.31593193
34	Circadian entrainment_Homo sapiens_hsa04713	1.30363171
35	Olfactory transduction_Homo sapiens_hsa04740	1.30284668
36	Propanoate metabolism_Homo sapiens_hsa00640	1.29757425
37	Proteasome_Homo sapiens_hsa03050	1.27583677
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.23561669
39	Sulfur relay system_Homo sapiens_hsa04122	1.19143694
40	Dopaminergic synapse_Homo sapiens_hsa04728	1.15268287
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13303853
42	Cocaine addiction_Homo sapiens_hsa05030	1.13299895
43	Fatty acid elongation_Homo sapiens_hsa00062	1.12723508
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11719719
45	Serotonergic synapse_Homo sapiens_hsa04726	1.11282820
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08362829
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06752044
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05518700
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04963005
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04412151
51	RNA degradation_Homo sapiens_hsa03018	1.01997273
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99181584
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97815402
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.90487087
55	Amphetamine addiction_Homo sapiens_hsa05031	0.89386459
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89005858
57	Mismatch repair_Homo sapiens_hsa03430	0.88566958
58	Insulin secretion_Homo sapiens_hsa04911	0.87615839
59	Purine metabolism_Homo sapiens_hsa00230	0.86276874
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84318062
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.81818610
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.77612574
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.75542998
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75277577
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.74679744
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73427295
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72766714
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.72597557
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.72469886
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68258086
71	Metabolic pathways_Homo sapiens_hsa01100	0.67746718
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66790198
73	ABC transporters_Homo sapiens_hsa02010	0.66753081
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62466004
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61699308
76	Long-term depression_Homo sapiens_hsa04730	0.61229242
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61082749
78	Retinol metabolism_Homo sapiens_hsa00830	0.60219123
79	Base excision repair_Homo sapiens_hsa03410	0.58401060
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54372198
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52282223
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51994830
83	Cholinergic synapse_Homo sapiens_hsa04725	0.50915775
84	Salivary secretion_Homo sapiens_hsa04970	0.49956954
85	Mineral absorption_Homo sapiens_hsa04978	0.49251114
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49221210
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46917392
88	Glutathione metabolism_Homo sapiens_hsa00480	0.46861445
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45535306
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42767034
91	Ribosome_Homo sapiens_hsa03010	0.42317290
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41522210
93	Folate biosynthesis_Homo sapiens_hsa00790	0.41310487
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.40498674
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.39770712
96	Gastric acid secretion_Homo sapiens_hsa04971	0.36748057
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35650678
98	One carbon pool by folate_Homo sapiens_hsa00670	0.35041737
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.34135967
100	RNA transport_Homo sapiens_hsa03013	0.33575396

TPTE2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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