ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	7.78067708
2	piRNA metabolic process (GO:0034587)	7.22141118
3	male meiosis (GO:0007140)	6.55701717
4	regulation of meiosis I (GO:0060631)	5.91458407
5	protein localization to cilium (GO:0061512)	5.89101384
6	water-soluble vitamin biosynthetic process (GO:0042364)	5.76789139
7	DNA methylation involved in gamete generation (GO:0043046)	5.23746847
8	negative regulation of execution phase of apoptosis (GO:1900118)	5.13185921
9	chromosome organization involved in meiosis (GO:0070192)	5.10744161
10	DNA double-strand break processing (GO:0000729)	4.88499767
11	male meiosis I (GO:0007141)	4.52552873
12	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.50170489
13	histone exchange (GO:0043486)	4.48446017
14	proteasome assembly (GO:0043248)	4.44933179
15	meiotic nuclear division (GO:0007126)	4.18975545
16	DNA synthesis involved in DNA repair (GO:0000731)	4.02523807
17	DNA replication checkpoint (GO:0000076)	3.99643014
18	cullin deneddylation (GO:0010388)	3.95540925
19	lactate metabolic process (GO:0006089)	3.86392792
20	spermatid development (GO:0007286)	3.85181947
21	synaptonemal complex assembly (GO:0007130)	3.82545792
22	kidney morphogenesis (GO:0060993)	3.81508553
23	oogenesis (GO:0048477)	3.67999926
24	protein neddylation (GO:0045116)	3.64031287
25	DNA catabolic process, exonucleolytic (GO:0000738)	3.57925170
26	reciprocal DNA recombination (GO:0035825)	3.55291159
27	reciprocal meiotic recombination (GO:0007131)	3.55291159
28	synaptonemal complex organization (GO:0070193)	3.50588893
29	negative regulation of meiosis (GO:0045835)	3.48601678
30	binding of sperm to zona pellucida (GO:0007339)	3.46370003
31	negative regulation of membrane potential (GO:0045837)	3.45896016
32	detection of calcium ion (GO:0005513)	3.44791052
33	protein deneddylation (GO:0000338)	3.42652847
34	dendritic spine morphogenesis (GO:0060997)	3.40656729
35	resolution of meiotic recombination intermediates (GO:0000712)	3.39859238
36	meiosis I (GO:0007127)	3.34523868
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.33739364
38	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.33418030
39	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.33418030
40	presynaptic membrane assembly (GO:0097105)	3.32148581
41	mitochondrion degradation (GO:0000422)	3.31715000
42	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.31382497
43	indolalkylamine catabolic process (GO:0046218)	3.31056841
44	tryptophan catabolic process (GO:0006569)	3.31056841
45	indole-containing compound catabolic process (GO:0042436)	3.31056841
46	meiotic cell cycle process (GO:1903046)	3.27792130
47	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26971068
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26971068
49	multicellular organism reproduction (GO:0032504)	3.22550016
50	sperm-egg recognition (GO:0035036)	3.20934771
51	prostate gland growth (GO:0060736)	3.20773192
52	tryptophan metabolic process (GO:0006568)	3.16181987
53	vitamin biosynthetic process (GO:0009110)	3.09690588
54	regulation of oxidative phosphorylation (GO:0002082)	3.09264546
55	sperm motility (GO:0030317)	3.08676559
56	rRNA methylation (GO:0031167)	3.08403215
57	nucleotide transmembrane transport (GO:1901679)	3.05894697
58	inner mitochondrial membrane organization (GO:0007007)	3.01505824
59	interkinetic nuclear migration (GO:0022027)	2.98574414
60	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.98254840
61	inositol phosphate dephosphorylation (GO:0046855)	2.98254840
62	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.96892412
63	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.96892412
64	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.96892412
65	rRNA modification (GO:0000154)	2.93692801
66	pantothenate metabolic process (GO:0015939)	2.93639857
67	inositol phosphate catabolic process (GO:0071545)	2.93167100
68	spindle assembly involved in mitosis (GO:0090307)	2.91234193
69	gonadal mesoderm development (GO:0007506)	2.91128190
70	sister chromatid cohesion (GO:0007062)	2.90249334
71	presynaptic membrane organization (GO:0097090)	2.88767517
72	respiratory chain complex IV assembly (GO:0008535)	2.88111084
73	female gamete generation (GO:0007292)	2.85892578
74	DNA replication-dependent nucleosome organization (GO:0034723)	2.82118470
75	DNA replication-dependent nucleosome assembly (GO:0006335)	2.82118470
76	glomerular visceral epithelial cell development (GO:0072015)	2.81725018
77	coenzyme catabolic process (GO:0009109)	2.81149762
78	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.80122610
79	recombinational repair (GO:0000725)	2.79590335
80	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.77311365
81	gene silencing by RNA (GO:0031047)	2.76966830
82	neural tube formation (GO:0001841)	2.75465569
83	regulation of glucokinase activity (GO:0033131)	2.75245901
84	regulation of hexokinase activity (GO:1903299)	2.75245901
85	lung secretory cell differentiation (GO:0061140)	2.75002901
86	double-strand break repair via homologous recombination (GO:0000724)	2.74977947
87	epithelial cilium movement (GO:0003351)	2.74849790
88	protein-cofactor linkage (GO:0018065)	2.74625876
89	cilium morphogenesis (GO:0060271)	2.72013423
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.70888172
91	DNA unwinding involved in DNA replication (GO:0006268)	2.70443185
92	germ cell development (GO:0007281)	2.69801487
93	DNA replication initiation (GO:0006270)	2.68808039
94	establishment of protein localization to Golgi (GO:0072600)	2.68089641
95	polyol catabolic process (GO:0046174)	2.67163749
96	mannosylation (GO:0097502)	2.67037023
97	acrosome reaction (GO:0007340)	2.66936376
98	indolalkylamine metabolic process (GO:0006586)	2.66541698
99	cell-cell recognition (GO:0009988)	2.65868739
100	non-recombinational repair (GO:0000726)	2.64144765

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.24508390
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.48748689
3	VDR_22108803_ChIP-Seq_LS180_Human	3.27809319
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27506022
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.91326545
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72281372
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63292191
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.60446138
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.43841739
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.34099776
11	FUS_26573619_Chip-Seq_HEK293_Human	2.30315457
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.28473012
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.12413071
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07972874
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.07798576
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02500907
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99627447
18	P300_19829295_ChIP-Seq_ESCs_Human	1.97488071
19	EWS_26573619_Chip-Seq_HEK293_Human	1.96703782
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89009756
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86656673
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86301669
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79585026
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.78331090
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.75390348
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.75240469
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73040468
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.71663793
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64454282
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64454282
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.62146065
32	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.55190895
33	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.54230186
34	AR_25329375_ChIP-Seq_VCAP_Human	1.51551087
35	AR_21909140_ChIP-Seq_LNCAP_Human	1.49169551
36	E2F7_22180533_ChIP-Seq_HELA_Human	1.47063072
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45346451
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.44444617
39	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44379329
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41541051
41	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40961264
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40876905
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40546436
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39792945
45	STAT3_23295773_ChIP-Seq_U87_Human	1.38511888
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32294778
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31085542
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29172234
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27361889
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.27145674
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.25812513
52	* CBP_20019798_ChIP-Seq_JUKART_Human	1.23388446
53	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23388446
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21549125
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21549125
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.20580958
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19932578
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19932578
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19840469
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17469058
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15939752
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.15529794
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15355951
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14964488
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.14304175
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10312146
67	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07896579
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07381809
69	TCF4_23295773_ChIP-Seq_U87_Human	1.06909151
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05933947
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05404909
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04102556
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03826164
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03749189
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03542331
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02077474
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01203270
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01189373
79	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99651487
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.99485434
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.99459818
82	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.98179815
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97447451
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96100487
85	CDX2_22108803_ChIP-Seq_LS180_Human	0.95418181
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95355782
87	NCOR_22424771_ChIP-Seq_293T_Human	0.94838972
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94186787
89	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92792613
90	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.92770749
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.92699785
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91407651
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90464106
94	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.89686259
95	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.89186174
96	TBL1_22424771_ChIP-Seq_293T_Human	0.88821610
97	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.88697454
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88563232
99	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.87406770
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87319259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.11577546
2	MP0008057_abnormal_DNA_replication	4.96597522
3	MP0008877_abnormal_DNA_methylation	4.30068098
4	MP0002160_abnormal_reproductive_system	3.08529857
5	MP0010234_abnormal_vibrissa_follicle	3.03424298
6	MP0008058_abnormal_DNA_repair	2.83106559
7	MP0001984_abnormal_olfaction	2.81082063
8	MP0003315_abnormal_perineum_morphology	2.56857534
9	MP0005410_abnormal_fertilization	2.56099263
10	MP0005379_endocrine/exocrine_gland_phen	2.48068546
11	MP0010352_gastrointestinal_tract_polyps	2.43849580
12	MP0001661_extended_life_span	2.36583538
13	MP0002139_abnormal_hepatobiliary_system	2.35148251
14	MP0005367_renal/urinary_system_phenotyp	2.24452298
15	MP0000516_abnormal_urinary_system	2.24452298
16	MP0001929_abnormal_gametogenesis	2.16060159
17	MP0009697_abnormal_copulation	2.07038098
18	MP0008875_abnormal_xenobiotic_pharmacok	2.05585589
19	MP0005647_abnormal_sex_gland	2.00798891
20	MP0003123_paternal_imprinting	1.99629168
21	MP0004084_abnormal_cardiac_muscle	1.98964659
22	MP0003122_maternal_imprinting	1.96773450
23	MP0003121_genomic_imprinting	1.94640167
24	MP0005423_abnormal_somatic_nervous	1.94585289
25	MP0003183_abnormal_peptide_metabolism	1.93316022
26	MP0003698_abnormal_male_reproductive	1.91951198
27	MP0002210_abnormal_sex_determination	1.79778910
28	MP0003718_maternal_effect	1.79665033
29	MP0004215_abnormal_myocardial_fiber	1.76666835
30	MP0001905_abnormal_dopamine_level	1.74642130
31	MP0003787_abnormal_imprinting	1.74376756
32	MP0005389_reproductive_system_phenotype	1.70266475
33	MP0001145_abnormal_male_reproductive	1.63647365
34	MP0003693_abnormal_embryo_hatching	1.56377280
35	MP0000653_abnormal_sex_gland	1.55511501
36	MP0003880_abnormal_central_pattern	1.51865167
37	MP0004133_heterotaxia	1.51231983
38	MP0008775_abnormal_heart_ventricle	1.49922216
39	MP0010094_abnormal_chromosome_stability	1.46824988
40	MP0003941_abnormal_skin_development	1.44362327
41	MP0006035_abnormal_mitochondrial_morpho	1.43666699
42	MP0006072_abnormal_retinal_apoptosis	1.43098216
43	MP0006054_spinal_hemorrhage	1.36366803
44	MP0008004_abnormal_stomach_pH	1.33763051
45	MP0010368_abnormal_lymphatic_system	1.30947857
46	MP0009046_muscle_twitch	1.29512178
47	MP0003195_calcinosis	1.29499244
48	MP0005248_abnormal_Harderian_gland	1.27198352
49	MP0009780_abnormal_chondrocyte_physiolo	1.21064465
50	MP0005646_abnormal_pituitary_gland	1.15828841
51	MP0000538_abnormal_urinary_bladder	1.15699538
52	MP0008007_abnormal_cellular_replicative	1.12168147
53	MP0003567_abnormal_fetal_cardiomyocyte	1.11729575
54	MP0001529_abnormal_vocalization	1.09687857
55	MP0004957_abnormal_blastocyst_morpholog	1.08326350
56	MP0002090_abnormal_vision	1.05335041
57	MP0010386_abnormal_urinary_bladder	1.03253503
58	MP0006036_abnormal_mitochondrial_physio	1.03225038
59	MP0005551_abnormal_eye_electrophysiolog	0.98858308
60	MP0003646_muscle_fatigue	0.97936181
61	MP0004036_abnormal_muscle_relaxation	0.96880385
62	MP0000427_abnormal_hair_cycle	0.94379450
63	MP0001485_abnormal_pinna_reflex	0.91710530
64	MP0005220_abnormal_exocrine_pancreas	0.91378356
65	MP0004484_altered_response_of	0.88992735
66	MP0002161_abnormal_fertility/fecundity	0.88787667
67	MP0002928_abnormal_bile_duct	0.88478342
68	MP0009745_abnormal_behavioral_response	0.87766911
69	MP0005187_abnormal_penis_morphology	0.85339094
70	MP0002736_abnormal_nociception_after	0.85273435
71	MP0004147_increased_porphyrin_level	0.82107444
72	MP0001119_abnormal_female_reproductive	0.81371124
73	MP0005332_abnormal_amino_acid	0.78804276
74	MP0002006_tumorigenesis	0.78561544
75	MP0005266_abnormal_metabolism	0.78554249
76	MP0001968_abnormal_touch/_nociception	0.77141192
77	MP0004782_abnormal_surfactant_physiolog	0.75789711
78	MP0004019_abnormal_vitamin_homeostasis	0.75759735
79	MP0001756_abnormal_urination	0.75635879
80	MP0005253_abnormal_eye_physiology	0.74670757
81	MP0001764_abnormal_homeostasis	0.74332472
82	MP0002638_abnormal_pupillary_reflex	0.71304860
83	MP0002272_abnormal_nervous_system	0.70864689
84	MP0002064_seizures	0.69668264
85	MP0002067_abnormal_sensory_capabilities	0.69186151
86	MP0010678_abnormal_skin_adnexa	0.69125356
87	MP0005499_abnormal_olfactory_system	0.68758002
88	MP0005394_taste/olfaction_phenotype	0.68758002
89	MP0002876_abnormal_thyroid_physiology	0.68722537
90	MP0002572_abnormal_emotion/affect_behav	0.64585047
91	MP0002751_abnormal_autonomic_nervous	0.63582263
92	MP0003936_abnormal_reproductive_system	0.62995004
93	MP0000230_abnormal_systemic_arterial	0.62078239
94	MP0010307_abnormal_tumor_latency	0.60940834
95	MP0008932_abnormal_embryonic_tissue	0.60414640
96	MP0001970_abnormal_pain_threshold	0.60162623
97	MP0008789_abnormal_olfactory_epithelium	0.59839533
98	MP0002733_abnormal_thermal_nociception	0.59553284
99	MP0002254_reproductive_system_inflammat	0.59287416
100	MP0002102_abnormal_ear_morphology	0.58399325

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubular atrophy (HP:0000092)	3.84235349
2	Urethral obstruction (HP:0000796)	3.70844065
3	Cutaneous melanoma (HP:0012056)	3.60491601
4	Dyschromatopsia (HP:0007641)	3.41724756
5	Abnormality of the labia minora (HP:0012880)	3.41131089
6	Nephronophthisis (HP:0000090)	3.31745270
7	Hematochezia (HP:0002573)	3.28046008
8	Pancreatic fibrosis (HP:0100732)	3.27171667
9	Ependymoma (HP:0002888)	3.25616145
10	Hypoplasia of the uterus (HP:0000013)	3.20956785
11	Pancreatic cysts (HP:0001737)	3.19254814
12	Progressive macrocephaly (HP:0004481)	3.14438575
13	Sensory axonal neuropathy (HP:0003390)	3.08172927
14	Type II lissencephaly (HP:0007260)	3.04135348
15	Abnormality of lateral ventricle (HP:0030047)	3.03615723
16	Occipital encephalocele (HP:0002085)	3.02194006
17	True hermaphroditism (HP:0010459)	2.99943021
18	Azoospermia (HP:0000027)	2.99001249
19	Enlarged penis (HP:0000040)	2.95100526
20	Neoplasm of the adrenal cortex (HP:0100641)	2.93474194
21	Hypoproteinemia (HP:0003075)	2.84169754
22	Colon cancer (HP:0003003)	2.83000356
23	Absent thumb (HP:0009777)	2.80958287
24	Aplasia/hypoplasia of the uterus (HP:0008684)	2.79487189
25	Absent/shortened dynein arms (HP:0200106)	2.78687706
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78687706
27	Mesangial abnormality (HP:0001966)	2.77949767
28	Volvulus (HP:0002580)	2.72181667
29	Male pseudohermaphroditism (HP:0000037)	2.71078893
30	Abnormality of the renal medulla (HP:0100957)	2.64687637
31	Asymmetry of the thorax (HP:0001555)	2.61811937
32	Abnormal ciliary motility (HP:0012262)	2.50457176
33	Cerebellar dysplasia (HP:0007033)	2.49519299
34	Abnormal spermatogenesis (HP:0008669)	2.48041918
35	High pitched voice (HP:0001620)	2.39936746
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.38555979
37	Acute necrotizing encephalopathy (HP:0006965)	2.34545813
38	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.33691374
39	Sclerocornea (HP:0000647)	2.30316662
40	Neoplasm of the oral cavity (HP:0100649)	2.27423610
41	Squamous cell carcinoma (HP:0002860)	2.24717656
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24002665
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.24002665
44	Tubulointerstitial nephritis (HP:0001970)	2.23472853
45	Neonatal respiratory distress (HP:0002643)	2.22154138
46	Furrowed tongue (HP:0000221)	2.22151312
47	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.20051042
48	Adenoma sebaceum (HP:0009720)	2.18527619
49	Angiofibromas (HP:0010615)	2.18527619
50	Acute encephalopathy (HP:0006846)	2.16916782
51	Retinal dysplasia (HP:0007973)	2.15430324
52	Buphthalmos (HP:0000557)	2.14521791
53	Increased CSF lactate (HP:0002490)	2.14465908
54	Atonic seizures (HP:0010819)	2.11609078
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.10716464
56	Hyperthyroidism (HP:0000836)	2.10647933
57	Limb dystonia (HP:0002451)	2.09455829
58	Lipid accumulation in hepatocytes (HP:0006561)	2.09045613
59	Horizontal nystagmus (HP:0000666)	2.08887610
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08757899
61	Small hand (HP:0200055)	2.07670772
62	Hemiparesis (HP:0001269)	2.07410055
63	Inability to walk (HP:0002540)	2.01472794
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.00893062
65	Conjunctival hamartoma (HP:0100780)	1.98550760
66	Supernumerary spleens (HP:0009799)	1.94074318
67	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93381280
68	Short tibia (HP:0005736)	1.92830925
69	Thyroiditis (HP:0100646)	1.92672052
70	Asplenia (HP:0001746)	1.92621435
71	Cystic liver disease (HP:0006706)	1.89106361
72	Palpebral edema (HP:0100540)	1.88636508
73	Acanthocytosis (HP:0001927)	1.88217635
74	Urinary urgency (HP:0000012)	1.87761589
75	Rhinitis (HP:0012384)	1.86611122
76	Astrocytoma (HP:0009592)	1.85931551
77	Abnormality of the astrocytes (HP:0100707)	1.85931551
78	Lissencephaly (HP:0001339)	1.85319483
79	Delayed gross motor development (HP:0002194)	1.83799426
80	Hamartoma of the eye (HP:0010568)	1.83218605
81	Abnormal protein glycosylation (HP:0012346)	1.80104915
82	Abnormal glycosylation (HP:0012345)	1.80104915
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80104915
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.80104915
85	Bowel diverticulosis (HP:0005222)	1.79107404
86	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78649857
87	Resting tremor (HP:0002322)	1.78426975
88	Abnormality of midbrain morphology (HP:0002418)	1.77927900
89	Molar tooth sign on MRI (HP:0002419)	1.77927900
90	Increased hepatocellular lipid droplets (HP:0006565)	1.77767554
91	Increased serum lactate (HP:0002151)	1.77401022
92	Carpal bone hypoplasia (HP:0001498)	1.76690146
93	Abnormal hair whorl (HP:0010721)	1.75051974
94	Lymphangioma (HP:0100764)	1.73789205
95	Abnormal auditory evoked potentials (HP:0006958)	1.72769626
96	Poor head control (HP:0002421)	1.72291962
97	Gonadal dysgenesis (HP:0000133)	1.72129870
98	Opisthotonus (HP:0002179)	1.71703381
99	Glioma (HP:0009733)	1.71300677
100	Aqueductal stenosis (HP:0002410)	1.71123373

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.00560530
2	MST4	6.05128328
3	PINK1	3.89977519
4	MAP4K2	3.73393177
5	FGFR2	3.50559569
6	NTRK3	3.26874843
7	ZAK	2.62405989
8	BMPR1B	2.43598655
9	STK3	2.17159465
10	OXSR1	2.17079475
11	WNK3	1.84530494
12	STK39	1.82978433
13	TAF1	1.78441072
14	ACVR1B	1.65414889
15	PLK3	1.62115236
16	EIF2AK3	1.59585492
17	TNIK	1.50326919
18	GRK1	1.49977627
19	TLK1	1.47398201
20	MKNK1	1.47357933
21	MARK3	1.46902530
22	STK16	1.30904176
23	CASK	1.28620107
24	STK38	1.28582882
25	STK10	1.27169310
26	PLK4	1.26785125
27	BUB1	1.26157582
28	STK38L	1.25344373
29	MKNK2	1.22807196
30	STK4	1.22231693
31	PLK2	1.18866487
32	PAK3	1.08900095
33	PLK1	1.07328737
34	TIE1	0.96272282
35	NUAK1	0.91377789
36	BCR	0.90373252
37	TSSK6	0.86551387
38	TTK	0.86538836
39	PNCK	0.83675521
40	FGFR3	0.83307291
41	PHKG1	0.82776071
42	PHKG2	0.82776071
43	PRKCI	0.80970667
44	PBK	0.79099204
45	CDK19	0.77220149
46	NLK	0.77206835
47	RPS6KA5	0.76562449
48	WNK4	0.73757451
49	DYRK3	0.72849796
50	ERBB3	0.68188986
51	MAPK13	0.62992103
52	TRIM28	0.62592634
53	ADRBK2	0.62260230
54	NEK2	0.58380968
55	CSNK1G1	0.58256893
56	MAPKAPK5	0.57300912
57	ADRBK1	0.56178247
58	DYRK2	0.55451045
59	STK11	0.55368744
60	PRKCE	0.55193656
61	CDC7	0.53326874
62	PTK2B	0.51374996
63	CSNK1G2	0.49475697
64	CSNK1G3	0.43691573
65	MAP3K4	0.42744630
66	NME1	0.42637359
67	FER	0.42297414
68	MYLK	0.41290499
69	TGFBR1	0.41166743
70	ROCK1	0.41055769
71	MARK1	0.40801327
72	ATM	0.40061134
73	SRPK1	0.39406744
74	CSNK1A1L	0.38756089
75	CDK14	0.38078969
76	EGFR	0.36917221
77	OBSCN	0.36261180
78	CDK5	0.36006086
79	VRK1	0.35482691
80	INSRR	0.34490400
81	WEE1	0.32564190
82	CDK3	0.32380004
83	PRKCQ	0.30645311
84	ATR	0.30545085
85	MINK1	0.30464643
86	YES1	0.29476571
87	PRKG1	0.28715048
88	AKT2	0.24915912
89	BRSK2	0.24511237
90	PRKCG	0.22734543
91	AURKA	0.20100630
92	ROCK2	0.19624785
93	ABL2	0.19576863
94	MAP3K8	0.17552870
95	TNK2	0.17372818
96	CAMK2A	0.17357975
97	DYRK1B	0.17134446
98	FGR	0.16979138
99	MAP2K7	0.16846543
100	EIF2AK2	0.16188608

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.87344966
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.52919841
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.77075156
4	Proteasome_Homo sapiens_hsa03050	2.74552534
5	Mismatch repair_Homo sapiens_hsa03430	2.74442278
6	Propanoate metabolism_Homo sapiens_hsa00640	2.65322483
7	Butanoate metabolism_Homo sapiens_hsa00650	2.38164366
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.33486809
9	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.24576120
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.03616518
11	DNA replication_Homo sapiens_hsa03030	1.99352234
12	Phototransduction_Homo sapiens_hsa04744	1.96951130
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.96096662
14	Homologous recombination_Homo sapiens_hsa03440	1.94907552
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.88620447
16	Protein export_Homo sapiens_hsa03060	1.86985529
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83197681
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.76784113
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74804070
20	One carbon pool by folate_Homo sapiens_hsa00670	1.72023104
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.71770709
22	Basal transcription factors_Homo sapiens_hsa03022	1.68211061
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.63302441
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.50586696
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48652130
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36695393
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31586600
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30600083
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29646334
30	RNA transport_Homo sapiens_hsa03013	1.27140897
31	Parkinsons disease_Homo sapiens_hsa05012	1.19073262
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.15819332
33	RNA polymerase_Homo sapiens_hsa03020	1.15265929
34	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.12935497
35	Caffeine metabolism_Homo sapiens_hsa00232	1.09080000
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07836828
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.07771503
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.06934318
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06926525
40	Glutathione metabolism_Homo sapiens_hsa00480	1.05387735
41	RNA degradation_Homo sapiens_hsa03018	1.05075707
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04734195
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04172040
44	Oocyte meiosis_Homo sapiens_hsa04114	1.02725932
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.96583824
46	Peroxisome_Homo sapiens_hsa04146	0.95963752
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95029645
48	Base excision repair_Homo sapiens_hsa03410	0.91850155
49	Retinol metabolism_Homo sapiens_hsa00830	0.88969503
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88234102
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86176191
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83850257
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82990956
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82775415
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82637586
56	Fatty acid degradation_Homo sapiens_hsa00071	0.82487060
57	Gap junction_Homo sapiens_hsa04540	0.82275657
58	Olfactory transduction_Homo sapiens_hsa04740	0.80022987
59	Regulation of autophagy_Homo sapiens_hsa04140	0.79189071
60	Purine metabolism_Homo sapiens_hsa00230	0.77755099
61	Cell cycle_Homo sapiens_hsa04110	0.75541369
62	Taste transduction_Homo sapiens_hsa04742	0.74483190
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.73270483
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.73022803
65	GABAergic synapse_Homo sapiens_hsa04727	0.70021099
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69622919
67	Metabolic pathways_Homo sapiens_hsa01100	0.69347208
68	Insulin secretion_Homo sapiens_hsa04911	0.69154797
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67578120
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.64921877
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64837305
72	Alzheimers disease_Homo sapiens_hsa05010	0.61181007
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60316166
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59823004
75	Fatty acid elongation_Homo sapiens_hsa00062	0.59616650
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58619102
77	Huntingtons disease_Homo sapiens_hsa05016	0.58318077
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55687181
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.54272648
80	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.53937203
81	Serotonergic synapse_Homo sapiens_hsa04726	0.53015183
82	p53 signaling pathway_Homo sapiens_hsa04115	0.52818653
83	Morphine addiction_Homo sapiens_hsa05032	0.51589872
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50676190
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49430770
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48518819
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48073291
88	Circadian entrainment_Homo sapiens_hsa04713	0.44920993
89	ABC transporters_Homo sapiens_hsa02010	0.44387228
90	Nicotine addiction_Homo sapiens_hsa05033	0.41103687
91	Renin secretion_Homo sapiens_hsa04924	0.40447315
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.40251182
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40097088
94	Pentose phosphate pathway_Homo sapiens_hsa00030	0.38905880
95	Ether lipid metabolism_Homo sapiens_hsa00565	0.37479909
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.37212005
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.33967670
98	Tight junction_Homo sapiens_hsa04530	0.33414266
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29863661
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.29318522

TPTE2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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