TPTE2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of sodium ion transport (GO:0010766)7.21242781
2regulation of relaxation of muscle (GO:1901077)7.06498270
3regulation of cell communication by electrical coupling (GO:0010649)6.01674752
4piRNA metabolic process (GO:0034587)5.39045047
5relaxation of cardiac muscle (GO:0055119)5.33376409
6regulation of action potential (GO:0098900)5.31310816
7platelet dense granule organization (GO:0060155)4.75048127
8cardiac right ventricle morphogenesis (GO:0003215)4.61956235
9synapsis (GO:0007129)4.60118819
10regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.51833097
11positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.42602987
12regulation of cilium movement (GO:0003352)4.31834000
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.27130764
14negative regulation of smooth muscle cell differentiation (GO:0051151)4.07836248
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.03451338
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.03451338
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.02107936
18NADH dehydrogenase complex assembly (GO:0010257)4.02107936
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02107936
20positive regulation of DNA-templated transcription, initiation (GO:2000144)3.98818688
21sulfation (GO:0051923)3.98256724
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.96795028
23response to pheromone (GO:0019236)3.93488310
24regulation of DNA-templated transcription, initiation (GO:2000142)3.87362907
25renal tubule morphogenesis (GO:0061333)3.84711726
26negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.81155229
27ventricular cardiac muscle cell development (GO:0055015)3.71673270
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.70689215
29regulation of acyl-CoA biosynthetic process (GO:0050812)3.66026315
30kidney mesenchyme development (GO:0072074)3.65639021
31protein complex biogenesis (GO:0070271)3.59747332
32regulation of cofactor metabolic process (GO:0051193)3.57990934
33regulation of coenzyme metabolic process (GO:0051196)3.57990934
34proteasome assembly (GO:0043248)3.53620126
35negative regulation of transcription regulatory region DNA binding (GO:2000678)3.49349377
36neurofilament cytoskeleton organization (GO:0060052)3.48340841
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44433688
38acrosome reaction (GO:0007340)3.40599892
39relaxation of muscle (GO:0090075)3.39067248
40neural tube formation (GO:0001841)3.30717558
41protein-cofactor linkage (GO:0018065)3.29934643
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.28919885
43keratinocyte development (GO:0003334)3.28611754
44serotonin metabolic process (GO:0042428)3.28402773
45positive regulation of muscle hypertrophy (GO:0014742)3.25431976
46positive regulation of cardiac muscle hypertrophy (GO:0010613)3.25431976
47metanephric mesenchyme development (GO:0072075)3.22729231
48positive regulation of meiosis (GO:0045836)3.22449334
49regulation of meiosis I (GO:0060631)3.20555537
50DNA methylation involved in gamete generation (GO:0043046)3.20399150
51positive regulation of catenin import into nucleus (GO:0035413)3.11351465
52phospholipid efflux (GO:0033700)3.08778852
53DNA integration (GO:0015074)3.07131640
54nephron tubule morphogenesis (GO:0072078)3.06028135
55nephron epithelium morphogenesis (GO:0072088)3.06028135
56regulation of cholesterol esterification (GO:0010872)3.05349415
57maturation of 5.8S rRNA (GO:0000460)3.03174405
58positive regulation of meiotic cell cycle (GO:0051446)3.02878535
59fatty acid elongation (GO:0030497)3.02026505
60phosphorelay signal transduction system (GO:0000160)3.00568705
61mitochondrial respiratory chain complex assembly (GO:0033108)2.97800558
62regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.96589367
63reverse cholesterol transport (GO:0043691)2.96550919
64resolution of meiotic recombination intermediates (GO:0000712)2.95458253
65cochlea development (GO:0090102)2.95199038
66fusion of sperm to egg plasma membrane (GO:0007342)2.94808679
67regulation of glucokinase activity (GO:0033131)2.92947909
68regulation of hexokinase activity (GO:1903299)2.92947909
69regulation of sulfur metabolic process (GO:0042762)2.91005803
70negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.90742115
71heme transport (GO:0015886)2.90434185
72male meiosis I (GO:0007141)2.90403478
73water-soluble vitamin biosynthetic process (GO:0042364)2.89422663
74ventricular trabecula myocardium morphogenesis (GO:0003222)2.89199391
75gamma-aminobutyric acid transport (GO:0015812)2.86893783
76regulation of heart rate by cardiac conduction (GO:0086091)2.86748436
77mitochondrial DNA replication (GO:0006264)2.83193432
78Notch signaling involved in heart development (GO:0061314)2.82180133
79pentose metabolic process (GO:0019321)2.81122407
80cellular hyperosmotic response (GO:0071474)2.80169488
81regulation of membrane depolarization (GO:0003254)2.76488420
82regulation of sodium ion transmembrane transporter activity (GO:2000649)2.76476232
83cellular ketone body metabolic process (GO:0046950)2.76142044
84negative regulation of striated muscle cell apoptotic process (GO:0010664)2.72598386
85embryonic epithelial tube formation (GO:0001838)2.69553127
86protein neddylation (GO:0045116)2.68579435
87respiratory chain complex IV assembly (GO:0008535)2.67144902
88histone H2A acetylation (GO:0043968)2.66319836
89renal absorption (GO:0070293)2.65380283
90indolalkylamine metabolic process (GO:0006586)2.64450693
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64281296
92primary amino compound metabolic process (GO:1901160)2.63995428
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62036638
94establishment of integrated proviral latency (GO:0075713)2.62032155
95ventricular system development (GO:0021591)2.58907201
96negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.55470118
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54998179
98plasma membrane fusion (GO:0045026)2.54929321
99gonadal mesoderm development (GO:0007506)2.54030624
100epithelial tube formation (GO:0072175)2.52890462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.74882110
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45672820
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40535029
4ZNF274_21170338_ChIP-Seq_K562_Hela3.32240278
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08693550
6IGF1R_20145208_ChIP-Seq_DFB_Human2.89191712
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88697752
8GBX2_23144817_ChIP-Seq_PC3_Human2.58378367
9TAF15_26573619_Chip-Seq_HEK293_Human2.44055022
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40977729
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39206515
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.29073060
13EWS_26573619_Chip-Seq_HEK293_Human2.25802034
14P300_19829295_ChIP-Seq_ESCs_Human2.20743158
15ELK1_19687146_ChIP-ChIP_HELA_Human2.08162868
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05021480
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00733741
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.99777410
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.99663343
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93799403
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85038929
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.81672574
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79436004
24CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71628359
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65537580
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63682072
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62764737
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62391250
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61762412
30CBP_20019798_ChIP-Seq_JUKART_Human1.61141198
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61141198
32ER_23166858_ChIP-Seq_MCF-7_Human1.56912023
33FOXA1_21572438_ChIP-Seq_LNCaP_Human1.55256503
34TBX3_20139965_ChIP-Seq_ESCs_Mouse1.53179544
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52034843
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51934463
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.51648446
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51594880
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51407340
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.51407340
41TBX3_20139965_ChIP-Seq_MESCs_Mouse1.51127291
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.49435394
43FUS_26573619_Chip-Seq_HEK293_Human1.45268394
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42543532
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41198506
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39034976
47ERG_20517297_ChIP-Seq_VCAP_Human1.35134941
48TP53_22573176_ChIP-Seq_HFKS_Human1.34731698
49CDX2_22108803_ChIP-Seq_LS180_Human1.34726355
50RNF2_27304074_Chip-Seq_NSC_Mouse1.34204490
51STAT3_23295773_ChIP-Seq_U87_Human1.34195377
52AR_25329375_ChIP-Seq_VCAP_Human1.30106914
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28789020
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28179008
55SOX2_19829295_ChIP-Seq_ESCs_Human1.26902592
56NANOG_19829295_ChIP-Seq_ESCs_Human1.26902592
57RUNX2_22187159_ChIP-Seq_PCA_Human1.25144980
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24203795
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23866788
60SMAD4_21799915_ChIP-Seq_A2780_Human1.22667025
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22016276
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21603402
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.21317039
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.19797806
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17818553
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17569749
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.15732334
68BCAT_22108803_ChIP-Seq_LS180_Human1.14690361
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14494167
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12907734
71AR_21572438_ChIP-Seq_LNCaP_Human1.12422828
72TCF4_23295773_ChIP-Seq_U87_Human1.11611041
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.11266308
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10448460
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10035026
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09527501
77TCF4_22108803_ChIP-Seq_LS180_Human1.09455399
78TP53_16413492_ChIP-PET_HCT116_Human1.08934627
79AR_20517297_ChIP-Seq_VCAP_Human1.08846443
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.08381759
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07688259
82P53_22387025_ChIP-Seq_ESCs_Mouse1.06857181
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06120733
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05752817
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.04745288
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03944261
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03680080
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01208903
89VDR_23849224_ChIP-Seq_CD4+_Human1.01162374
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00193474
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00098563
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98257200
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.97629492
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.97372695
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96595129
96FOXP3_21729870_ChIP-Seq_TREG_Human0.95386926
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94728584
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.94713294
99JUN_21703547_ChIP-Seq_K562_Human0.93771229
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.93425806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.94216367
2MP0003880_abnormal_central_pattern4.41442614
3MP0005423_abnormal_somatic_nervous3.48201029
4MP0008877_abnormal_DNA_methylation2.69220741
5MP0001986_abnormal_taste_sensitivity2.61691457
6MP0000372_irregular_coat_pigmentation2.46522056
7MP0006054_spinal_hemorrhage2.39757262
8MP0006276_abnormal_autonomic_nervous2.37270873
9MP0009384_cardiac_valve_regurgitation2.27895996
10MP0002160_abnormal_reproductive_system2.18113283
11MP0006035_abnormal_mitochondrial_morpho2.16878721
12MP0002736_abnormal_nociception_after2.04073768
13MP0004885_abnormal_endolymph1.89503476
14MP0008058_abnormal_DNA_repair1.88499782
15MP0005174_abnormal_tail_pigmentation1.86792415
16MP0010368_abnormal_lymphatic_system1.86585203
17MP0003119_abnormal_digestive_system1.75865926
18MP0005551_abnormal_eye_electrophysiolog1.74648241
19MP0001485_abnormal_pinna_reflex1.73875794
20MP0008995_early_reproductive_senescence1.72032024
21MP0001529_abnormal_vocalization1.68790369
22MP0002139_abnormal_hepatobiliary_system1.62250100
23MP0004147_increased_porphyrin_level1.60474713
24MP0003136_yellow_coat_color1.59132492
25MP0003718_maternal_effect1.55132124
26MP0001968_abnormal_touch/_nociception1.52953811
27MP0005075_abnormal_melanosome_morpholog1.49189776
28MP0003567_abnormal_fetal_cardiomyocyte1.47368987
29MP0005084_abnormal_gallbladder_morpholo1.45995663
30MP0005410_abnormal_fertilization1.44442916
31MP0000516_abnormal_urinary_system1.37434559
32MP0005367_renal/urinary_system_phenotyp1.37434559
33MP0004484_altered_response_of1.37043879
34MP0002572_abnormal_emotion/affect_behav1.34606342
35MP0001984_abnormal_olfaction1.34273913
36MP0008875_abnormal_xenobiotic_pharmacok1.30382485
37MP0008775_abnormal_heart_ventricle1.29751539
38MP0005330_cardiomyopathy1.29629104
39MP0002638_abnormal_pupillary_reflex1.29118189
40MP0002733_abnormal_thermal_nociception1.28043828
41MP0003122_maternal_imprinting1.27109671
42MP0000749_muscle_degeneration1.24351657
43MP0005389_reproductive_system_phenotype1.24002622
44MP0009840_abnormal_foam_cell1.21839302
45MP0003186_abnormal_redox_activity1.21726759
46MP0002102_abnormal_ear_morphology1.21209671
47MP0005409_darkened_coat_color1.20508248
48MP0002876_abnormal_thyroid_physiology1.18191745
49MP0002272_abnormal_nervous_system1.14412861
50MP0005595_abnormal_vascular_smooth1.13399579
51MP0002009_preneoplasia1.10769260
52MP0004085_abnormal_heartbeat1.10549749
53MP0004215_abnormal_myocardial_fiber1.09767171
54MP0000462_abnormal_digestive_system1.09106113
55MP0005647_abnormal_sex_gland1.07678064
56MP0001929_abnormal_gametogenesis1.07536567
57MP0001756_abnormal_urination1.05921447
58MP0000537_abnormal_urethra_morphology1.05444977
59MP0001188_hyperpigmentation1.04577869
60MP0005332_abnormal_amino_acid1.02953385
61MP0000470_abnormal_stomach_morphology1.02236577
62MP0002210_abnormal_sex_determination1.00881226
63MP0001970_abnormal_pain_threshold1.00119831
64MP0005167_abnormal_blood-brain_barrier1.00060670
65MP0005253_abnormal_eye_physiology0.99506660
66MP0002928_abnormal_bile_duct0.98622949
67MP0004133_heterotaxia0.98373793
68MP0001324_abnormal_eye_pigmentation0.96944521
69MP0003698_abnormal_male_reproductive0.94963239
70MP0002163_abnormal_gland_morphology0.94825282
71MP0005620_abnormal_muscle_contractility0.93480236
72MP0000230_abnormal_systemic_arterial0.93435029
73MP0002127_abnormal_cardiovascular_syste0.92026723
74MP0001664_abnormal_digestion0.91766152
75MP0010094_abnormal_chromosome_stability0.91373490
76MP0003137_abnormal_impulse_conducting0.90961550
77MP0000427_abnormal_hair_cycle0.90022339
78MP0003937_abnormal_limbs/digits/tail_de0.89304728
79MP0001486_abnormal_startle_reflex0.87712798
80MP0000653_abnormal_sex_gland0.87401776
81MP0002229_neurodegeneration0.87337293
82MP0004924_abnormal_behavior0.87203897
83MP0005386_behavior/neurological_phenoty0.87203897
84MP0003195_calcinosis0.85291184
85MP0003191_abnormal_cellular_cholesterol0.84235791
86MP0003011_delayed_dark_adaptation0.83736657
87MP0005365_abnormal_bile_salt0.83629956
88MP0001501_abnormal_sleep_pattern0.81909068
89MP0008872_abnormal_physiological_respon0.79921450
90MP0000015_abnormal_ear_pigmentation0.79831290
91MP0001145_abnormal_male_reproductive0.79360115
92MP0005645_abnormal_hypothalamus_physiol0.79062771
93MP0005448_abnormal_energy_balance0.78056819
94MP0005379_endocrine/exocrine_gland_phen0.77144155
95MP0000639_abnormal_adrenal_gland0.77115411
96MP0000358_abnormal_cell_content/0.77067174
97MP0009745_abnormal_behavioral_response0.76829021
98MP0004272_abnormal_basement_membrane0.74075621
99MP0002269_muscular_atrophy0.73536848
100MP0001879_abnormal_lymphatic_vessel0.71420783

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.41744292
2Hyperalaninemia (HP:0003348)4.41744292
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.41744292
4Posterior subcapsular cataract (HP:0007787)4.25225492
5Concave nail (HP:0001598)4.15970949
6Hepatocellular necrosis (HP:0001404)3.61028813
7Ependymoma (HP:0002888)3.53709944
8Colon cancer (HP:0003003)3.26499713
9Hepatic necrosis (HP:0002605)3.24275866
10Type I diabetes mellitus (HP:0100651)3.19423657
11Hypoplasia of the uterus (HP:0000013)2.95610290
12Methylmalonic acidemia (HP:0002912)2.94302977
13Increased CSF lactate (HP:0002490)2.93612948
14Increased corneal curvature (HP:0100692)2.92167157
15Keratoconus (HP:0000563)2.92167157
16Congenital, generalized hypertrichosis (HP:0004540)2.88374331
17Agnosia (HP:0010524)2.88000904
18Methylmalonic aciduria (HP:0012120)2.83405455
19Increased serum pyruvate (HP:0003542)2.78351306
20Cone-rod dystrophy (HP:0000548)2.74846060
21Mitochondrial inheritance (HP:0001427)2.72940397
22Abnormality of the labia minora (HP:0012880)2.71248440
23Chronic hepatic failure (HP:0100626)2.69533945
24Scotoma (HP:0000575)2.69408292
25Occipital encephalocele (HP:0002085)2.69196890
26Birth length less than 3rd percentile (HP:0003561)2.64805638
27Abnormality of glycolysis (HP:0004366)2.64339406
28Hypothermia (HP:0002045)2.53093848
29Abnormality of serum amino acid levels (HP:0003112)2.52813867
30Increased serum lactate (HP:0002151)2.52145172
31Aplasia/hypoplasia of the uterus (HP:0008684)2.50093201
32Limb dystonia (HP:0002451)2.48429050
33CNS demyelination (HP:0007305)2.48049426
34Abnormality of macular pigmentation (HP:0008002)2.46366199
35Constricted visual fields (HP:0001133)2.44457759
36Retinal atrophy (HP:0001105)2.42859027
37True hermaphroditism (HP:0010459)2.42270916
38Subcapsular cataract (HP:0000523)2.39426108
39Prostate neoplasm (HP:0100787)2.38378133
40Macular degeneration (HP:0000608)2.32796164
41Generalized aminoaciduria (HP:0002909)2.29019642
42Nephronophthisis (HP:0000090)2.28378145
43Anencephaly (HP:0002323)2.27683068
44Dysdiadochokinesis (HP:0002075)2.27176645
45Lactic acidosis (HP:0003128)2.25828695
46Abnormality of midbrain morphology (HP:0002418)2.23124584
47Molar tooth sign on MRI (HP:0002419)2.23124584
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.22598168
49Homocystinuria (HP:0002156)2.22172635
50Abnormality of homocysteine metabolism (HP:0010919)2.22172635
51Short tibia (HP:0005736)2.21599729
52Polyphagia (HP:0002591)2.18363453
53Pancreatic cysts (HP:0001737)2.17991845
54Focal segmental glomerulosclerosis (HP:0000097)2.17605029
55Hyperglycinemia (HP:0002154)2.15647955
56Astrocytoma (HP:0009592)2.15426222
57Abnormality of the astrocytes (HP:0100707)2.15426222
58Abnormal hair whorl (HP:0010721)2.14971010
59Respiratory difficulties (HP:0002880)2.11829224
60Glioma (HP:0009733)2.11429392
61Hyperglycemia (HP:0003074)2.09871085
62Pancreatic fibrosis (HP:0100732)2.06880984
63Septate vagina (HP:0001153)2.06038276
64Glomerulosclerosis (HP:0000096)2.04322010
65Abnormality of the renal medulla (HP:0100957)2.03949116
66Genetic anticipation (HP:0003743)2.01414022
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00215564
68CNS hypomyelination (HP:0003429)1.99448591
69Ulnar claw (HP:0001178)1.98402554
70Facial diplegia (HP:0001349)1.98255069
71Acute necrotizing encephalopathy (HP:0006965)1.97923050
72Anterior segment dysgenesis (HP:0007700)1.95939158
73Acute encephalopathy (HP:0006846)1.94407529
74Emotional lability (HP:0000712)1.94363254
75Central scotoma (HP:0000603)1.90326429
76Attenuation of retinal blood vessels (HP:0007843)1.89220913
77Proximal tubulopathy (HP:0000114)1.86928421
78Abnormality of the ischium (HP:0003174)1.86588068
79Nasal speech (HP:0001611)1.86364228
80Thyroid-stimulating hormone excess (HP:0002925)1.86153631
81Progressive cerebellar ataxia (HP:0002073)1.85104889
82Limb hypertonia (HP:0002509)1.85036179
83Tubulointerstitial nephritis (HP:0001970)1.82022861
84Congenital stationary night blindness (HP:0007642)1.81624765
85Glycosuria (HP:0003076)1.81372011
86Abnormality of urine glucose concentration (HP:0011016)1.81372011
87Hemiparesis (HP:0001269)1.80623397
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.79956855
89Abolished electroretinogram (ERG) (HP:0000550)1.79541658
90Bile duct proliferation (HP:0001408)1.78320255
91Abnormal biliary tract physiology (HP:0012439)1.78320255
92Hypoalphalipoproteinemia (HP:0003233)1.78231360
93Abnormality of vitamin B metabolism (HP:0004340)1.77712643
94Chorioretinal atrophy (HP:0000533)1.77044147
95Poor suck (HP:0002033)1.75724040
96Amelogenesis imperfecta (HP:0000705)1.74676928
97Respiratory failure (HP:0002878)1.74254678
98Spontaneous abortion (HP:0005268)1.74220204
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.72467398
100Cerebral edema (HP:0002181)1.72113771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.54187486
2MST44.49400355
3TAF14.32681417
4PNCK3.57669833
5MAP4K23.35797391
6TRIM283.14152082
7VRK23.10083104
8TAOK32.52932715
9BCKDK2.52002050
10CDK192.31209014
11WEE12.27911219
12ZAK2.04631041
13GRK11.96130192
14SIK31.94420553
15WNK41.91320385
16KIT1.83543971
17ADRBK21.81313148
18NUAK11.77119888
19MAP3K101.69302020
20STK391.64840699
21ACVR1B1.50939980
22BCR1.42763473
23VRK11.41410837
24WNK31.38697300
25TNIK1.37320104
26DYRK1B1.28761708
27FRK1.24255973
28CAMKK21.21360948
29PINK11.18277313
30PBK1.16860987
31TSSK61.07484728
32PASK1.07019774
33PAK31.05561489
34DAPK21.01920542
35FES0.97743262
36MAPK150.95867572
37STK380.92699887
38MINK10.88074849
39PTK2B0.86998393
40DAPK10.86487606
41INSRR0.85839870
42PLK30.83305375
43CDK30.80279124
44TGFBR10.79758633
45STK160.78309519
46MATK0.78108691
47BMPR1B0.78101966
48CAMK2D0.74857934
49OXSR10.72137376
50MET0.69953539
51PRKCG0.67826970
52GRK50.64853579
53RPS6KB10.62711322
54DYRK20.62376591
55MAP3K120.61939155
56NLK0.61575674
57NEK90.59414870
58BRSK20.58466858
59CAMK2A0.57090087
60PRKCE0.57060532
61DAPK30.56125837
62MAP2K60.55918287
63PHKG20.54811578
64PHKG10.54811578
65PLK40.54106556
66TESK10.52039039
67CCNB10.51288966
68NTRK20.51096713
69PRKG10.49090305
70PLK20.45158626
71MAPK130.44987610
72RIPK40.41929495
73ATR0.41564456
74MAP3K20.40936637
75NEK10.40036442
76GSK3A0.39328170
77MELK0.37447141
78YES10.36164875
79ADRBK10.35990042
80PDGFRB0.34829596
81MYLK0.34354029
82CSF1R0.33746056
83OBSCN0.33501203
84PLK10.33352005
85EIF2AK30.32975297
86MAP3K50.32121293
87CDK70.29614565
88EPHB20.29574392
89FLT30.29507571
90PRKACA0.29025823
91ATM0.28442694
92ERBB40.26847425
93PRKCB0.26248955
94ABL20.26231793
95CSNK1D0.25999153
96CSNK1A10.25808634
97CSNK2A10.25188537
98CSNK1E0.24925053
99MAPK90.24365366
100PRKCA0.24353498

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.31785852
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.11936302
3Fatty acid elongation_Homo sapiens_hsa000622.97093185
4Propanoate metabolism_Homo sapiens_hsa006402.65494676
5Caffeine metabolism_Homo sapiens_hsa002322.60500861
6Protein export_Homo sapiens_hsa030602.20507846
7Non-homologous end-joining_Homo sapiens_hsa034502.18382321
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16669991
9ABC transporters_Homo sapiens_hsa020102.12905671
10Phototransduction_Homo sapiens_hsa047442.11251429
11Basal transcription factors_Homo sapiens_hsa030222.09298298
12Oxidative phosphorylation_Homo sapiens_hsa001901.98344596
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91943674
14Olfactory transduction_Homo sapiens_hsa047401.85266416
15Fanconi anemia pathway_Homo sapiens_hsa034601.83570666
16Mismatch repair_Homo sapiens_hsa034301.83345054
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.75344207
18Linoleic acid metabolism_Homo sapiens_hsa005911.74697667
19Parkinsons disease_Homo sapiens_hsa050121.69659769
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67520439
21Tryptophan metabolism_Homo sapiens_hsa003801.59910715
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59447513
23Fat digestion and absorption_Homo sapiens_hsa049751.56067991
24Circadian entrainment_Homo sapiens_hsa047131.44508398
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.34764742
26Butanoate metabolism_Homo sapiens_hsa006501.31468588
27Homologous recombination_Homo sapiens_hsa034401.30828047
28Pyruvate metabolism_Homo sapiens_hsa006201.27462875
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27440513
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26806698
31Histidine metabolism_Homo sapiens_hsa003401.23993724
32Amphetamine addiction_Homo sapiens_hsa050311.23688755
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22282451
34RNA degradation_Homo sapiens_hsa030181.22169500
35Taste transduction_Homo sapiens_hsa047421.20165745
36Nitrogen metabolism_Homo sapiens_hsa009101.19572944
37One carbon pool by folate_Homo sapiens_hsa006701.18007347
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15461349
39RNA polymerase_Homo sapiens_hsa030201.12037225
40Cardiac muscle contraction_Homo sapiens_hsa042601.11846287
41Insulin secretion_Homo sapiens_hsa049111.06428971
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05918966
43Purine metabolism_Homo sapiens_hsa002301.05838938
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03058214
45Serotonergic synapse_Homo sapiens_hsa047261.01235277
46Gastric acid secretion_Homo sapiens_hsa049711.00237635
47Peroxisome_Homo sapiens_hsa041460.98099334
48DNA replication_Homo sapiens_hsa030300.97225526
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97109133
50Proteasome_Homo sapiens_hsa030500.92691636
51Calcium signaling pathway_Homo sapiens_hsa040200.91828894
52Huntingtons disease_Homo sapiens_hsa050160.91768786
53Ribosome_Homo sapiens_hsa030100.91178334
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90462587
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90245974
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89265542
57Oocyte meiosis_Homo sapiens_hsa041140.88636528
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84608286
59Salivary secretion_Homo sapiens_hsa049700.84579909
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81458902
61Alzheimers disease_Homo sapiens_hsa050100.81139432
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.80992320
63Regulation of autophagy_Homo sapiens_hsa041400.80593445
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79419589
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77818067
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76085097
67Retinol metabolism_Homo sapiens_hsa008300.74407890
68Starch and sucrose metabolism_Homo sapiens_hsa005000.71647923
69Morphine addiction_Homo sapiens_hsa050320.70774585
70Base excision repair_Homo sapiens_hsa034100.69260815
71Mineral absorption_Homo sapiens_hsa049780.66695406
72Glutathione metabolism_Homo sapiens_hsa004800.66213715
73Glucagon signaling pathway_Homo sapiens_hsa049220.65533951
74Metabolic pathways_Homo sapiens_hsa011000.65193888
75Sulfur relay system_Homo sapiens_hsa041220.64852254
76Chemical carcinogenesis_Homo sapiens_hsa052040.64539128
77Ether lipid metabolism_Homo sapiens_hsa005650.61858517
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60578402
79Arachidonic acid metabolism_Homo sapiens_hsa005900.60300406
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59853886
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58936413
82Fatty acid metabolism_Homo sapiens_hsa012120.57819792
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57819260
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57797273
85Dopaminergic synapse_Homo sapiens_hsa047280.56937493
86RNA transport_Homo sapiens_hsa030130.56892599
87TGF-beta signaling pathway_Homo sapiens_hsa043500.56736603
88Nicotine addiction_Homo sapiens_hsa050330.54008421
89Arginine and proline metabolism_Homo sapiens_hsa003300.51303568
90Folate biosynthesis_Homo sapiens_hsa007900.49915020
91Galactose metabolism_Homo sapiens_hsa000520.49878793
92Cholinergic synapse_Homo sapiens_hsa047250.48882023
93Steroid biosynthesis_Homo sapiens_hsa001000.46192503
94Oxytocin signaling pathway_Homo sapiens_hsa049210.45020045
95Fatty acid degradation_Homo sapiens_hsa000710.44492765
96Pyrimidine metabolism_Homo sapiens_hsa002400.43827572
97Collecting duct acid secretion_Homo sapiens_hsa049660.42289984
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42110984
99HIF-1 signaling pathway_Homo sapiens_hsa040660.40905376
100Cell cycle_Homo sapiens_hsa041100.40472298

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »