TPTE2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.35775862
2thalamus development (GO:0021794)4.43902491
3epithelial cilium movement (GO:0003351)4.28145155
4regulation of mesenchymal cell apoptotic process (GO:2001053)3.96737215
5DNA deamination (GO:0045006)3.88393392
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87278853
7protein complex biogenesis (GO:0070271)3.84475615
8amine catabolic process (GO:0009310)3.84391656
9cellular biogenic amine catabolic process (GO:0042402)3.84391656
10gamma-aminobutyric acid transport (GO:0015812)3.74537979
11sulfation (GO:0051923)3.66238407
12coenzyme catabolic process (GO:0009109)3.62418210
13nonmotile primary cilium assembly (GO:0035058)3.59364468
14retinal cone cell development (GO:0046549)3.55643841
15behavioral response to nicotine (GO:0035095)3.46736343
16dopamine transport (GO:0015872)3.45335971
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38666826
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.38666826
19NADH dehydrogenase complex assembly (GO:0010257)3.38666826
20retina layer formation (GO:0010842)3.38085818
21cilium movement (GO:0003341)3.37033107
22negative regulation of response to food (GO:0032096)3.32846004
23negative regulation of appetite (GO:0032099)3.32846004
24protein prenylation (GO:0018342)3.30852894
25prenylation (GO:0097354)3.30852894
26mitochondrial respiratory chain complex assembly (GO:0033108)3.18042184
27transmission of nerve impulse (GO:0019226)3.15016483
28cilium organization (GO:0044782)3.10477824
29positive regulation of glycolytic process (GO:0045821)3.08237209
30cilium morphogenesis (GO:0060271)3.07407356
31pancreas development (GO:0031016)3.06694990
32otic vesicle formation (GO:0030916)3.03716786
33negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00450814
34cellular ketone body metabolic process (GO:0046950)2.99123065
35cell wall macromolecule metabolic process (GO:0044036)2.97567745
36inositol phosphate catabolic process (GO:0071545)2.95159033
37presynaptic membrane assembly (GO:0097105)2.94168358
38cell wall macromolecule catabolic process (GO:0016998)2.93993486
39cellular response to leptin stimulus (GO:0044320)2.93007989
40cilium assembly (GO:0042384)2.92261349
41axonemal dynein complex assembly (GO:0070286)2.90267137
42indolalkylamine metabolic process (GO:0006586)2.89658671
43photoreceptor cell development (GO:0042461)2.89149901
44sperm motility (GO:0030317)2.87941040
45presynaptic membrane organization (GO:0097090)2.85971486
46nitric oxide mediated signal transduction (GO:0007263)2.85702266
47estrogen biosynthetic process (GO:0006703)2.82668561
48cytidine metabolic process (GO:0046087)2.79565753
49cytidine catabolic process (GO:0006216)2.79565753
50cytidine deamination (GO:0009972)2.79565753
51eye photoreceptor cell development (GO:0042462)2.79061765
52regulation of cilium movement (GO:0003352)2.78344999
53endocrine pancreas development (GO:0031018)2.77145868
54respiratory chain complex IV assembly (GO:0008535)2.75184564
55negative regulation of multicellular organism growth (GO:0040015)2.70392279
56intraciliary transport (GO:0042073)2.68988905
57behavioral response to ethanol (GO:0048149)2.67897456
58negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.64196986
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63033298
60ketone body metabolic process (GO:1902224)2.61787313
61anterograde synaptic vesicle transport (GO:0048490)2.60498093
62inner mitochondrial membrane organization (GO:0007007)2.60431419
63photoreceptor cell maintenance (GO:0045494)2.60419733
64tryptophan catabolic process (GO:0006569)2.59454824
65indole-containing compound catabolic process (GO:0042436)2.59454824
66indolalkylamine catabolic process (GO:0046218)2.59454824
67exocrine pancreas development (GO:0031017)2.59195546
68dendritic spine morphogenesis (GO:0060997)2.58596253
69negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57765286
70phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56116690
71inositol phosphate dephosphorylation (GO:0046855)2.56116690
72tryptophan metabolic process (GO:0006568)2.55934814
73regulation of dopamine secretion (GO:0014059)2.55927723
74cytochrome complex assembly (GO:0017004)2.55484309
75negative regulation of heart rate (GO:0010459)2.54857718
76brain morphogenesis (GO:0048854)2.54769255
77regulation of feeding behavior (GO:0060259)2.54463449
78organelle disassembly (GO:1903008)2.53873389
79negative regulation of telomere maintenance (GO:0032205)2.53432498
80photoreceptor cell differentiation (GO:0046530)2.53378825
81eye photoreceptor cell differentiation (GO:0001754)2.53378825
82cornea development in camera-type eye (GO:0061303)2.53176846
83cilium or flagellum-dependent cell motility (GO:0001539)2.52852412
84relaxation of smooth muscle (GO:0044557)2.52350099
85somite development (GO:0061053)2.51983564
86midbrain development (GO:0030901)2.51760344
87retinal rod cell development (GO:0046548)2.50975520
88cellular response to nicotine (GO:0071316)2.50887527
89smoothened signaling pathway (GO:0007224)2.50523330
90artery smooth muscle contraction (GO:0014824)2.50445913
91seminiferous tubule development (GO:0072520)2.48913734
92hindbrain development (GO:0030902)2.48677459
93neuronal action potential (GO:0019228)2.48415454
94neuron fate determination (GO:0048664)2.47771063
95protein polyglutamylation (GO:0018095)2.47754005
96pituitary gland development (GO:0021983)2.46232416
97water-soluble vitamin biosynthetic process (GO:0042364)2.45189808
98pyrimidine ribonucleoside catabolic process (GO:0046133)2.44826770
99detection of light stimulus involved in visual perception (GO:0050908)2.43989089
100detection of light stimulus involved in sensory perception (GO:0050962)2.43989089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.34866811
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.20340033
3GBX2_23144817_ChIP-Seq_PC3_Human3.52209824
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13590366
5VDR_22108803_ChIP-Seq_LS180_Human2.97992209
6ZNF274_21170338_ChIP-Seq_K562_Hela2.67704425
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57421861
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48635582
9FUS_26573619_Chip-Seq_HEK293_Human2.24884279
10EZH2_22144423_ChIP-Seq_EOC_Human2.22789558
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21425131
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15661030
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.13877145
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12528942
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09229591
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08170504
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.07824535
18P300_19829295_ChIP-Seq_ESCs_Human2.07554929
19TAF15_26573619_Chip-Seq_HEK293_Human2.03582506
20EWS_26573619_Chip-Seq_HEK293_Human1.97133942
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89551473
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89384477
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81867004
24RNF2_27304074_Chip-Seq_NSC_Mouse1.78956999
25ER_23166858_ChIP-Seq_MCF-7_Human1.74416012
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74379870
27CBP_20019798_ChIP-Seq_JUKART_Human1.74379870
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.60350737
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59833109
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54372289
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.54077852
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53221731
33IRF1_19129219_ChIP-ChIP_H3396_Human1.52358179
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51274812
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49018457
36SMAD4_21799915_ChIP-Seq_A2780_Human1.47597503
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44870149
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43838591
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43157386
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42648979
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42189204
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41527548
43AR_25329375_ChIP-Seq_VCAP_Human1.40046576
44STAT3_23295773_ChIP-Seq_U87_Human1.38349681
45BCAT_22108803_ChIP-Seq_LS180_Human1.37928120
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34264079
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33071411
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32622035
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.29218747
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27534764
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27534764
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26527399
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.26415472
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.24425261
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24247607
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23109895
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23086373
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22740412
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22580196
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.22457355
61RUNX2_22187159_ChIP-Seq_PCA_Human1.20811866
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.19786518
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19370134
64MYC_18940864_ChIP-ChIP_HL60_Human1.18375373
65TP53_22573176_ChIP-Seq_HFKS_Human1.18082537
66TCF4_23295773_ChIP-Seq_U87_Human1.18040775
67SOX2_19829295_ChIP-Seq_ESCs_Human1.17252668
68NANOG_19829295_ChIP-Seq_ESCs_Human1.17252668
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.15901496
70CDX2_22108803_ChIP-Seq_LS180_Human1.15502401
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14716299
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14587077
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14474787
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14136269
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13335223
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13234079
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13065932
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.12192946
79TCF4_22108803_ChIP-Seq_LS180_Human1.11623142
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11573702
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09422274
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07941152
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06875341
84REST_21632747_ChIP-Seq_MESCs_Mouse1.05335770
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.03999629
86P53_22387025_ChIP-Seq_ESCs_Mouse1.03825714
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03264127
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02699882
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01936241
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.00844202
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00563773
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.00563773
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.00152347
94AR_21572438_ChIP-Seq_LNCaP_Human0.99616232
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98505175
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.98069739
97AR_20517297_ChIP-Seq_VCAP_Human0.97156305
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96886426
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96760970
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.96429111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.98885249
2MP0005646_abnormal_pituitary_gland2.89144542
3MP0003136_yellow_coat_color2.81906546
4MP0008004_abnormal_stomach_pH2.63483478
5MP0006276_abnormal_autonomic_nervous2.53352511
6MP0000569_abnormal_digit_pigmentation2.47086601
7MP0002736_abnormal_nociception_after2.31352780
8MP0001529_abnormal_vocalization2.30187883
9MP0001968_abnormal_touch/_nociception2.25750438
10MP0001984_abnormal_olfaction2.25247910
11MP0003011_delayed_dark_adaptation2.23176076
12MP0005645_abnormal_hypothalamus_physiol2.19515464
13MP0005085_abnormal_gallbladder_physiolo2.19189565
14MP0002102_abnormal_ear_morphology2.15881998
15MP0001501_abnormal_sleep_pattern2.08888518
16MP0009697_abnormal_copulation2.04223554
17MP0008877_abnormal_DNA_methylation2.02042044
18MP0006072_abnormal_retinal_apoptosis2.00689174
19MP0002837_dystrophic_cardiac_calcinosis1.95000594
20MP0005551_abnormal_eye_electrophysiolog1.92525730
21MP0005187_abnormal_penis_morphology1.90665600
22MP0004142_abnormal_muscle_tone1.90058953
23MP0008995_early_reproductive_senescence1.79729125
24MP0002822_catalepsy1.71114408
25MP0005084_abnormal_gallbladder_morpholo1.71112985
26MP0005253_abnormal_eye_physiology1.66079777
27MP0001664_abnormal_digestion1.63992517
28MP0009745_abnormal_behavioral_response1.53652481
29MP0002928_abnormal_bile_duct1.51806661
30MP0000631_abnormal_neuroendocrine_gland1.51354861
31MP0003315_abnormal_perineum_morphology1.46343505
32MP0003122_maternal_imprinting1.45862520
33MP0002132_abnormal_respiratory_system1.45150409
34MP0000427_abnormal_hair_cycle1.44492965
35MP0002184_abnormal_innervation1.40997228
36MP0002272_abnormal_nervous_system1.39446828
37MP0001486_abnormal_startle_reflex1.39040834
38MP0005423_abnormal_somatic_nervous1.36920949
39MP0009046_muscle_twitch1.36034030
40MP0003252_abnormal_bile_duct1.35479307
41MP0001986_abnormal_taste_sensitivity1.34061583
42MP0005410_abnormal_fertilization1.32605429
43MP0002572_abnormal_emotion/affect_behav1.29955634
44MP0003787_abnormal_imprinting1.29320292
45MP0001905_abnormal_dopamine_level1.25390851
46MP0008872_abnormal_physiological_respon1.20625205
47MP0001502_abnormal_circadian_rhythm1.18696292
48MP0000383_abnormal_hair_follicle1.18472511
49MP0002638_abnormal_pupillary_reflex1.17308163
50MP0001764_abnormal_homeostasis1.17147621
51MP0002557_abnormal_social/conspecific_i1.15798740
52MP0005367_renal/urinary_system_phenotyp1.14223768
53MP0000516_abnormal_urinary_system1.14223768
54MP0010386_abnormal_urinary_bladder1.13531506
55MP0005174_abnormal_tail_pigmentation1.12092897
56MP0005248_abnormal_Harderian_gland1.09813866
57MP0002160_abnormal_reproductive_system1.08524797
58MP0004484_altered_response_of1.08453543
59MP0002067_abnormal_sensory_capabilities1.07713312
60MP0006292_abnormal_olfactory_placode1.06880549
61MP0004145_abnormal_muscle_electrophysio1.03732971
62MP0001970_abnormal_pain_threshold1.02525899
63MP0003195_calcinosis1.01093278
64MP0003698_abnormal_male_reproductive1.00662258
65MP0002138_abnormal_hepatobiliary_system1.00613234
66MP0004924_abnormal_behavior0.99181920
67MP0005386_behavior/neurological_phenoty0.99181920
68MP0002064_seizures0.98894841
69MP0005167_abnormal_blood-brain_barrier0.98865202
70MP0004858_abnormal_nervous_system0.98500361
71MP0003806_abnormal_nucleotide_metabolis0.98321578
72MP0003718_maternal_effect0.98090714
73MP0005075_abnormal_melanosome_morpholog0.97263664
74MP0000778_abnormal_nervous_system0.96237962
75MP0004084_abnormal_cardiac_muscle0.95842959
76MP0001485_abnormal_pinna_reflex0.94616391
77MP0000013_abnormal_adipose_tissue0.91777603
78MP0002277_abnormal_respiratory_mucosa0.91772000
79MP0000372_irregular_coat_pigmentation0.91605832
80MP0005389_reproductive_system_phenotype0.90415666
81MP0002938_white_spotting0.89193335
82MP0006035_abnormal_mitochondrial_morpho0.89145694
83MP0001440_abnormal_grooming_behavior0.88966915
84MP0000538_abnormal_urinary_bladder0.87774822
85MP0002063_abnormal_learning/memory/cond0.87347511
86MP0008875_abnormal_xenobiotic_pharmacok0.86750126
87MP0002752_abnormal_somatic_nervous0.85834292
88MP0010678_abnormal_skin_adnexa0.85523768
89MP0002127_abnormal_cardiovascular_syste0.85505902
90MP0002733_abnormal_thermal_nociception0.83954630
91MP0000230_abnormal_systemic_arterial0.82881509
92MP0005195_abnormal_posterior_eye0.81346441
93MP0002909_abnormal_adrenal_gland0.81256699
94MP0001929_abnormal_gametogenesis0.80793933
95MP0002735_abnormal_chemical_nociception0.80535909
96MP0000049_abnormal_middle_ear0.79930487
97MP0002090_abnormal_vision0.79152827
98MP0004085_abnormal_heartbeat0.78370471
99MP0002254_reproductive_system_inflammat0.78154095
100MP0002282_abnormal_trachea_morphology0.77906818

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.83623243
2Pancreatic cysts (HP:0001737)4.38011580
3Medial flaring of the eyebrow (HP:0010747)4.33298235
4Pancreatic fibrosis (HP:0100732)3.90302028
5Nephronophthisis (HP:0000090)3.83853956
6Gait imbalance (HP:0002141)3.70222970
7Molar tooth sign on MRI (HP:0002419)3.51979107
8Abnormality of midbrain morphology (HP:0002418)3.51979107
9Congenital primary aphakia (HP:0007707)3.43194506
10Type II lissencephaly (HP:0007260)3.21539162
11Abnormality of the renal medulla (HP:0100957)3.14828463
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.13108609
13Concave nail (HP:0001598)3.07727336
14Nephrogenic diabetes insipidus (HP:0009806)3.03025233
15Abnormality of the renal cortex (HP:0011035)2.94540687
16Abnormal rod and cone electroretinograms (HP:0008323)2.88503979
173-Methylglutaconic aciduria (HP:0003535)2.87355388
18Cystic liver disease (HP:0006706)2.80018865
19Optic nerve hypoplasia (HP:0000609)2.78439350
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.73281249
21Renal cortical cysts (HP:0000803)2.69565028
22Male pseudohermaphroditism (HP:0000037)2.68667217
23Congenital stationary night blindness (HP:0007642)2.67270338
24Poor coordination (HP:0002370)2.62288564
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58713674
26Febrile seizures (HP:0002373)2.54164038
27Hypothermia (HP:0002045)2.53774868
28Sclerocornea (HP:0000647)2.48266842
29Hyperventilation (HP:0002883)2.45389231
30Chronic hepatic failure (HP:0100626)2.43239785
31Short phalanx of the thumb (HP:0009660)2.42862707
32Neoplasm of the heart (HP:0100544)2.42172105
33Pigmentary retinal degeneration (HP:0001146)2.40134146
34Vaginal atresia (HP:0000148)2.39991337
35Hyperinsulinemic hypoglycemia (HP:0000825)2.38425200
36Genital tract atresia (HP:0001827)2.35328724
37Polyphagia (HP:0002591)2.35304059
38Acute necrotizing encephalopathy (HP:0006965)2.33464269
39Abnormal ciliary motility (HP:0012262)2.30637886
40Attenuation of retinal blood vessels (HP:0007843)2.27461280
41Acute encephalopathy (HP:0006846)2.27214378
42Progressive macrocephaly (HP:0004481)2.25474315
43Abnormal mitochondria in muscle tissue (HP:0008316)2.21636579
44Hemiparesis (HP:0001269)2.20958488
45Mitochondrial inheritance (HP:0001427)2.20544150
46Abnormality of the labia minora (HP:0012880)2.20420638
47Aplasia/hypoplasia of the uterus (HP:0008684)2.20059528
48Atonic seizures (HP:0010819)2.18507361
49Congenital hepatic fibrosis (HP:0002612)2.18061210
50Hypoplasia of the uterus (HP:0000013)2.16535690
51Abnormal drinking behavior (HP:0030082)2.16336019
52Polydipsia (HP:0001959)2.16336019
53Thyroid-stimulating hormone excess (HP:0002925)2.14043305
54Tubulointerstitial nephritis (HP:0001970)2.13962793
55Specific learning disability (HP:0001328)2.13892837
56Abnormal respiratory motile cilium physiology (HP:0012261)2.13693924
57Postaxial foot polydactyly (HP:0001830)2.11502990
58Tubular atrophy (HP:0000092)2.11158755
59Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.07738727
60Occipital encephalocele (HP:0002085)2.07268789
61Furrowed tongue (HP:0000221)2.07132453
62Gaze-evoked nystagmus (HP:0000640)2.05474509
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04453874
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04453874
65Increased CSF lactate (HP:0002490)2.02752254
66Cerebellar dysplasia (HP:0007033)1.99216910
67Calf muscle hypertrophy (HP:0008981)1.98155325
68Postaxial hand polydactyly (HP:0001162)1.98015941
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95262721
70Decreased central vision (HP:0007663)1.92965755
71Chorioretinal atrophy (HP:0000533)1.92824163
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.92531020
73Absent/shortened dynein arms (HP:0200106)1.92531020
74Hepatic necrosis (HP:0002605)1.90410828
75Retinal dysplasia (HP:0007973)1.90006183
76Thyroiditis (HP:0100646)1.88091406
77Hepatocellular necrosis (HP:0001404)1.87566498
78Progressive cerebellar ataxia (HP:0002073)1.87402640
79Anencephaly (HP:0002323)1.86234630
80Type I diabetes mellitus (HP:0100651)1.86165071
81Short 1st metacarpal (HP:0010034)1.85983763
82Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85983763
83Abnormal biliary tract physiology (HP:0012439)1.85690055
84Bile duct proliferation (HP:0001408)1.85690055
85Intestinal atresia (HP:0011100)1.84173991
86Abnormal respiratory motile cilium morphology (HP:0005938)1.81982125
87Abnormal respiratory epithelium morphology (HP:0012253)1.81982125
88Tongue fasciculations (HP:0001308)1.81398178
89Failure to thrive in infancy (HP:0001531)1.79295793
90Short chin (HP:0000331)1.78153627
91Poor suck (HP:0002033)1.77757919
92Central scotoma (HP:0000603)1.76573397
93Reduced antithrombin III activity (HP:0001976)1.76518129
94Gonadal dysgenesis (HP:0000133)1.76036782
95Rimmed vacuoles (HP:0003805)1.74257587
96Large for gestational age (HP:0001520)1.73966755
97Aplasia/Hypoplasia of the lens (HP:0008063)1.73468333
98Hypoglycemic coma (HP:0001325)1.71861287
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.71540997
100Muscle hypertrophy of the lower extremities (HP:0008968)1.70910407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.59934333
2FRK4.29385760
3BCKDK2.92340334
4MAP2K72.61531786
5MAPK132.46567240
6ZAK2.24598226
7TAOK32.24283618
8TRIM282.21022825
9PHKG12.14122683
10PHKG22.14122683
11MAP3K42.07550358
12VRK11.97618409
13CASK1.97172532
14TNIK1.91853580
15WNK31.90654643
16ADRBK21.77068006
17MAP4K21.74799377
18CSNK1G31.63963025
19GRK11.62383543
20BMPR1B1.58953357
21TLK11.56963694
22CSNK1G11.52924686
23CDK191.52584739
24CSNK1A1L1.46500339
25VRK21.43252069
26AKT31.42073814
27CSNK1G21.41588422
28OBSCN1.40813917
29DYRK21.38539240
30MAPK151.37963024
31NLK1.34752601
32GRK51.17139447
33CAMKK21.13839469
34KIT1.07676719
35BRSK21.07408865
36DYRK31.06005892
37PLK21.02426640
38NME11.02088382
39ARAF0.96670044
40MARK10.95376659
41PTK2B0.93464364
42MAP2K40.90198987
43TIE10.89647055
44WEE10.88679378
45MAP3K60.88103062
46NUAK10.86033549
47PRKCE0.84242809
48ADRBK10.84048046
49OXSR10.83832725
50TESK20.82896001
51GRK60.82603554
52PAK30.81809718
53STK38L0.80359782
54PNCK0.75362896
55PRKCQ0.73456084
56TNK20.71575986
57PKN10.70475202
58EPHA40.70188611
59MAPKAPK30.69785238
60MAPKAPK50.68706364
61PLK30.68586391
62EIF2AK30.67971340
63INSRR0.67196892
64PRKCG0.66421373
65MARK30.61492803
66KDR0.60485740
67BCR0.60103996
68TEC0.60000517
69SGK20.56564786
70PRKG20.52360447
71ERBB30.51961226
72PIM20.51319817
73FGFR20.50720574
74TXK0.48932735
75CAMK10.47613975
76LMTK20.47058324
77DYRK1A0.46966814
78FLT30.45843137
79CDK30.45261730
80NTRK30.45237950
81RPS6KA50.44432426
82NTRK20.44372113
83STK240.43294185
84EIF2AK20.42287528
85PRKACA0.41633470
86PRKCI0.38547566
87DAPK20.38175506
88GRK70.36896393
89BLK0.36743333
90CSNK1A10.34448023
91SGK2230.32184874
92SGK4940.32184874
93MYLK0.31878748
94TGFBR10.31591455
95MAP2K60.31518332
96SRPK10.30176752
97RAF10.29545130
98CAMK2A0.29486271
99PIK3CG0.29034790
100CSNK1D0.27763333

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.01424749
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97159313
3Nitrogen metabolism_Homo sapiens_hsa009102.89993492
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.86716610
5Oxidative phosphorylation_Homo sapiens_hsa001902.79478696
6Parkinsons disease_Homo sapiens_hsa050122.49129682
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.31083432
8Phototransduction_Homo sapiens_hsa047442.21419497
9Nicotine addiction_Homo sapiens_hsa050332.06913029
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91740448
11Circadian rhythm_Homo sapiens_hsa047101.88812688
12Chemical carcinogenesis_Homo sapiens_hsa052041.87624264
13Protein export_Homo sapiens_hsa030601.84962038
14Propanoate metabolism_Homo sapiens_hsa006401.70926568
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68424855
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61539775
17Olfactory transduction_Homo sapiens_hsa047401.60641117
18Alzheimers disease_Homo sapiens_hsa050101.60401517
19Regulation of autophagy_Homo sapiens_hsa041401.53828130
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.50711613
21ABC transporters_Homo sapiens_hsa020101.50327540
22Cardiac muscle contraction_Homo sapiens_hsa042601.47846839
23Circadian entrainment_Homo sapiens_hsa047131.47533676
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47229591
25Taste transduction_Homo sapiens_hsa047421.46786639
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45584340
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45515546
28Fatty acid elongation_Homo sapiens_hsa000621.40985859
29Huntingtons disease_Homo sapiens_hsa050161.40887741
30Homologous recombination_Homo sapiens_hsa034401.40469314
31Morphine addiction_Homo sapiens_hsa050321.40109593
32GABAergic synapse_Homo sapiens_hsa047271.39999262
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36985781
34Peroxisome_Homo sapiens_hsa041461.34223547
35Hedgehog signaling pathway_Homo sapiens_hsa043401.31031582
36Caffeine metabolism_Homo sapiens_hsa002321.30368585
37beta-Alanine metabolism_Homo sapiens_hsa004101.29990395
38Tryptophan metabolism_Homo sapiens_hsa003801.28289224
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26655998
40RNA polymerase_Homo sapiens_hsa030201.21560282
41Basal transcription factors_Homo sapiens_hsa030221.19946047
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19853657
43Linoleic acid metabolism_Homo sapiens_hsa005911.15717601
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06320314
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05527975
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03744522
47Basal cell carcinoma_Homo sapiens_hsa052171.01439655
48Serotonergic synapse_Homo sapiens_hsa047260.98126557
49Insulin secretion_Homo sapiens_hsa049110.95468945
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92978311
51Purine metabolism_Homo sapiens_hsa002300.92706043
52Salivary secretion_Homo sapiens_hsa049700.89757100
53Arachidonic acid metabolism_Homo sapiens_hsa005900.88857756
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.87379672
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86422123
56Collecting duct acid secretion_Homo sapiens_hsa049660.86356538
57Proteasome_Homo sapiens_hsa030500.86172272
58Fatty acid metabolism_Homo sapiens_hsa012120.83212734
59Alcoholism_Homo sapiens_hsa050340.83117264
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79233088
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77740857
62Fanconi anemia pathway_Homo sapiens_hsa034600.76953587
63Retinol metabolism_Homo sapiens_hsa008300.75879850
64Systemic lupus erythematosus_Homo sapiens_hsa053220.74546367
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74207055
66Ribosome_Homo sapiens_hsa030100.72562803
67Glycerolipid metabolism_Homo sapiens_hsa005610.72485393
68Renin secretion_Homo sapiens_hsa049240.70769030
69Glutathione metabolism_Homo sapiens_hsa004800.69065744
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68066752
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66128557
72RNA degradation_Homo sapiens_hsa030180.64735981
73Selenocompound metabolism_Homo sapiens_hsa004500.64550868
74Oxytocin signaling pathway_Homo sapiens_hsa049210.64546299
75Arginine and proline metabolism_Homo sapiens_hsa003300.63833912
76Fatty acid degradation_Homo sapiens_hsa000710.62680237
77Metabolic pathways_Homo sapiens_hsa011000.58367187
78Starch and sucrose metabolism_Homo sapiens_hsa005000.57272221
79Long-term depression_Homo sapiens_hsa047300.56341239
80Pyrimidine metabolism_Homo sapiens_hsa002400.56150893
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54809987
82Glutamatergic synapse_Homo sapiens_hsa047240.52548951
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50876541
84Fatty acid biosynthesis_Homo sapiens_hsa000610.49148665
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48848542
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.48827304
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47363844
88Gap junction_Homo sapiens_hsa045400.47186521
89Gastric acid secretion_Homo sapiens_hsa049710.46454726
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46415783
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44313107
92Calcium signaling pathway_Homo sapiens_hsa040200.44226006
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42994550
94Dopaminergic synapse_Homo sapiens_hsa047280.42562938
95Dorso-ventral axis formation_Homo sapiens_hsa043200.42357142
96Mineral absorption_Homo sapiens_hsa049780.37832799
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37216890
98Ovarian steroidogenesis_Homo sapiens_hsa049130.36509393
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35868910
100Bile secretion_Homo sapiens_hsa049760.34112334

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