ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	5.35775862
2	thalamus development (GO:0021794)	4.43902491
3	epithelial cilium movement (GO:0003351)	4.28145155
4	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.96737215
5	DNA deamination (GO:0045006)	3.88393392
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87278853
7	protein complex biogenesis (GO:0070271)	3.84475615
8	cellular biogenic amine catabolic process (GO:0042402)	3.84391656
9	amine catabolic process (GO:0009310)	3.84391656
10	gamma-aminobutyric acid transport (GO:0015812)	3.74537979
11	sulfation (GO:0051923)	3.66238407
12	coenzyme catabolic process (GO:0009109)	3.62418210
13	nonmotile primary cilium assembly (GO:0035058)	3.59364468
14	retinal cone cell development (GO:0046549)	3.55643841
15	behavioral response to nicotine (GO:0035095)	3.46736343
16	dopamine transport (GO:0015872)	3.45335971
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.38666826
18	NADH dehydrogenase complex assembly (GO:0010257)	3.38666826
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.38666826
20	retina layer formation (GO:0010842)	3.38085818
21	cilium movement (GO:0003341)	3.37033107
22	negative regulation of appetite (GO:0032099)	3.32846004
23	negative regulation of response to food (GO:0032096)	3.32846004
24	prenylation (GO:0097354)	3.30852894
25	protein prenylation (GO:0018342)	3.30852894
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18042184
27	transmission of nerve impulse (GO:0019226)	3.15016483
28	cilium organization (GO:0044782)	3.10477824
29	positive regulation of glycolytic process (GO:0045821)	3.08237209
30	cilium morphogenesis (GO:0060271)	3.07407356
31	pancreas development (GO:0031016)	3.06694990
32	otic vesicle formation (GO:0030916)	3.03716786
33	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.00450814
34	cellular ketone body metabolic process (GO:0046950)	2.99123065
35	cell wall macromolecule metabolic process (GO:0044036)	2.97567745
36	inositol phosphate catabolic process (GO:0071545)	2.95159033
37	presynaptic membrane assembly (GO:0097105)	2.94168358
38	cell wall macromolecule catabolic process (GO:0016998)	2.93993486
39	cellular response to leptin stimulus (GO:0044320)	2.93007989
40	cilium assembly (GO:0042384)	2.92261349
41	axonemal dynein complex assembly (GO:0070286)	2.90267137
42	indolalkylamine metabolic process (GO:0006586)	2.89658671
43	photoreceptor cell development (GO:0042461)	2.89149901
44	sperm motility (GO:0030317)	2.87941040
45	presynaptic membrane organization (GO:0097090)	2.85971486
46	nitric oxide mediated signal transduction (GO:0007263)	2.85702266
47	estrogen biosynthetic process (GO:0006703)	2.82668561
48	cytidine deamination (GO:0009972)	2.79565753
49	cytidine metabolic process (GO:0046087)	2.79565753
50	cytidine catabolic process (GO:0006216)	2.79565753
51	eye photoreceptor cell development (GO:0042462)	2.79061765
52	regulation of cilium movement (GO:0003352)	2.78344999
53	endocrine pancreas development (GO:0031018)	2.77145868
54	respiratory chain complex IV assembly (GO:0008535)	2.75184564
55	negative regulation of multicellular organism growth (GO:0040015)	2.70392279
56	intraciliary transport (GO:0042073)	2.68988905
57	behavioral response to ethanol (GO:0048149)	2.67897456
58	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.64196986
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.63033298
60	ketone body metabolic process (GO:1902224)	2.61787313
61	anterograde synaptic vesicle transport (GO:0048490)	2.60498093
62	inner mitochondrial membrane organization (GO:0007007)	2.60431419
63	photoreceptor cell maintenance (GO:0045494)	2.60419733
64	indole-containing compound catabolic process (GO:0042436)	2.59454824
65	indolalkylamine catabolic process (GO:0046218)	2.59454824
66	tryptophan catabolic process (GO:0006569)	2.59454824
67	exocrine pancreas development (GO:0031017)	2.59195546
68	dendritic spine morphogenesis (GO:0060997)	2.58596253
69	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.57765286
70	inositol phosphate dephosphorylation (GO:0046855)	2.56116690
71	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.56116690
72	tryptophan metabolic process (GO:0006568)	2.55934814
73	regulation of dopamine secretion (GO:0014059)	2.55927723
74	cytochrome complex assembly (GO:0017004)	2.55484309
75	negative regulation of heart rate (GO:0010459)	2.54857718
76	brain morphogenesis (GO:0048854)	2.54769255
77	regulation of feeding behavior (GO:0060259)	2.54463449
78	organelle disassembly (GO:1903008)	2.53873389
79	negative regulation of telomere maintenance (GO:0032205)	2.53432498
80	eye photoreceptor cell differentiation (GO:0001754)	2.53378825
81	photoreceptor cell differentiation (GO:0046530)	2.53378825
82	cornea development in camera-type eye (GO:0061303)	2.53176846
83	cilium or flagellum-dependent cell motility (GO:0001539)	2.52852412
84	relaxation of smooth muscle (GO:0044557)	2.52350099
85	somite development (GO:0061053)	2.51983564
86	midbrain development (GO:0030901)	2.51760344
87	retinal rod cell development (GO:0046548)	2.50975520
88	cellular response to nicotine (GO:0071316)	2.50887527
89	smoothened signaling pathway (GO:0007224)	2.50523330
90	artery smooth muscle contraction (GO:0014824)	2.50445913
91	seminiferous tubule development (GO:0072520)	2.48913734
92	hindbrain development (GO:0030902)	2.48677459
93	neuronal action potential (GO:0019228)	2.48415454
94	neuron fate determination (GO:0048664)	2.47771063
95	protein polyglutamylation (GO:0018095)	2.47754005
96	pituitary gland development (GO:0021983)	2.46232416
97	water-soluble vitamin biosynthetic process (GO:0042364)	2.45189808
98	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.44826770
99	detection of light stimulus involved in visual perception (GO:0050908)	2.43989089
100	detection of light stimulus involved in sensory perception (GO:0050962)	2.43989089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.34866811
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.20340033
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.52209824
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.13590366
5	VDR_22108803_ChIP-Seq_LS180_Human	2.97992209
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67704425
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57421861
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48635582
9	FUS_26573619_Chip-Seq_HEK293_Human	2.24884279
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.22789558
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21425131
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15661030
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.13877145
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12528942
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09229591
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08170504
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07824535
18	P300_19829295_ChIP-Seq_ESCs_Human	2.07554929
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.03582506
20	EWS_26573619_Chip-Seq_HEK293_Human	1.97133942
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.89551473
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89384477
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81867004
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.78956999
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.74416012
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.74379870
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74379870
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60350737
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59833109
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54372289
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54077852
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53221731
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52358179
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51274812
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49018457
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47597503
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44870149
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43838591
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43157386
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42648979
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42189204
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41527548
43	AR_25329375_ChIP-Seq_VCAP_Human	1.40046576
44	STAT3_23295773_ChIP-Seq_U87_Human	1.38349681
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.37928120
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34264079
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33071411
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32622035
49	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29218747
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27534764
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27534764
52	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.26527399
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26415472
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24425261
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.24247607
56	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.23109895
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23086373
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22740412
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22580196
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.22457355
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20811866
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19786518
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19370134
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.18375373
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.18082537
66	TCF4_23295773_ChIP-Seq_U87_Human	1.18040775
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17252668
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17252668
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15901496
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.15502401
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14716299
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14587077
73	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14474787
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14136269
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13335223
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13234079
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13065932
78	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.12192946
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.11623142
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11573702
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09422274
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07941152
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06875341
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05335770
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03999629
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03825714
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03264127
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02699882
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01936241
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00844202
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00563773
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00563773
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00152347
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.99616232
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98505175
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98069739
97	AR_20517297_ChIP-Seq_VCAP_Human	0.97156305
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.96886426
99	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.96760970
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96429111

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.98885249
2	MP0005646_abnormal_pituitary_gland	2.89144542
3	MP0003136_yellow_coat_color	2.81906546
4	MP0008004_abnormal_stomach_pH	2.63483478
5	MP0006276_abnormal_autonomic_nervous	2.53352511
6	MP0000569_abnormal_digit_pigmentation	2.47086601
7	MP0002736_abnormal_nociception_after	2.31352780
8	MP0001529_abnormal_vocalization	2.30187883
9	MP0001968_abnormal_touch/_nociception	2.25750438
10	MP0001984_abnormal_olfaction	2.25247910
11	MP0003011_delayed_dark_adaptation	2.23176076
12	MP0005645_abnormal_hypothalamus_physiol	2.19515464
13	MP0005085_abnormal_gallbladder_physiolo	2.19189565
14	MP0002102_abnormal_ear_morphology	2.15881998
15	MP0001501_abnormal_sleep_pattern	2.08888518
16	MP0009697_abnormal_copulation	2.04223554
17	MP0008877_abnormal_DNA_methylation	2.02042044
18	MP0006072_abnormal_retinal_apoptosis	2.00689174
19	MP0002837_dystrophic_cardiac_calcinosis	1.95000594
20	MP0005551_abnormal_eye_electrophysiolog	1.92525730
21	MP0005187_abnormal_penis_morphology	1.90665600
22	MP0004142_abnormal_muscle_tone	1.90058953
23	MP0008995_early_reproductive_senescence	1.79729125
24	MP0002822_catalepsy	1.71114408
25	MP0005084_abnormal_gallbladder_morpholo	1.71112985
26	MP0005253_abnormal_eye_physiology	1.66079777
27	MP0001664_abnormal_digestion	1.63992517
28	MP0009745_abnormal_behavioral_response	1.53652481
29	MP0002928_abnormal_bile_duct	1.51806661
30	MP0000631_abnormal_neuroendocrine_gland	1.51354861
31	MP0003315_abnormal_perineum_morphology	1.46343505
32	MP0003122_maternal_imprinting	1.45862520
33	MP0002132_abnormal_respiratory_system	1.45150409
34	MP0000427_abnormal_hair_cycle	1.44492965
35	MP0002184_abnormal_innervation	1.40997228
36	MP0002272_abnormal_nervous_system	1.39446828
37	MP0001486_abnormal_startle_reflex	1.39040834
38	MP0005423_abnormal_somatic_nervous	1.36920949
39	MP0009046_muscle_twitch	1.36034030
40	MP0003252_abnormal_bile_duct	1.35479307
41	MP0001986_abnormal_taste_sensitivity	1.34061583
42	MP0005410_abnormal_fertilization	1.32605429
43	MP0002572_abnormal_emotion/affect_behav	1.29955634
44	MP0003787_abnormal_imprinting	1.29320292
45	MP0001905_abnormal_dopamine_level	1.25390851
46	MP0008872_abnormal_physiological_respon	1.20625205
47	MP0001502_abnormal_circadian_rhythm	1.18696292
48	MP0000383_abnormal_hair_follicle	1.18472511
49	MP0002638_abnormal_pupillary_reflex	1.17308163
50	MP0001764_abnormal_homeostasis	1.17147621
51	MP0002557_abnormal_social/conspecific_i	1.15798740
52	MP0000516_abnormal_urinary_system	1.14223768
53	MP0005367_renal/urinary_system_phenotyp	1.14223768
54	MP0010386_abnormal_urinary_bladder	1.13531506
55	MP0005174_abnormal_tail_pigmentation	1.12092897
56	MP0005248_abnormal_Harderian_gland	1.09813866
57	MP0002160_abnormal_reproductive_system	1.08524797
58	MP0004484_altered_response_of	1.08453543
59	MP0002067_abnormal_sensory_capabilities	1.07713312
60	MP0006292_abnormal_olfactory_placode	1.06880549
61	MP0004145_abnormal_muscle_electrophysio	1.03732971
62	MP0001970_abnormal_pain_threshold	1.02525899
63	MP0003195_calcinosis	1.01093278
64	MP0003698_abnormal_male_reproductive	1.00662258
65	MP0002138_abnormal_hepatobiliary_system	1.00613234
66	MP0005386_behavior/neurological_phenoty	0.99181920
67	MP0004924_abnormal_behavior	0.99181920
68	MP0002064_seizures	0.98894841
69	MP0005167_abnormal_blood-brain_barrier	0.98865202
70	MP0004858_abnormal_nervous_system	0.98500361
71	MP0003806_abnormal_nucleotide_metabolis	0.98321578
72	MP0003718_maternal_effect	0.98090714
73	MP0005075_abnormal_melanosome_morpholog	0.97263664
74	MP0000778_abnormal_nervous_system	0.96237962
75	MP0004084_abnormal_cardiac_muscle	0.95842959
76	MP0001485_abnormal_pinna_reflex	0.94616391
77	MP0000013_abnormal_adipose_tissue	0.91777603
78	MP0002277_abnormal_respiratory_mucosa	0.91772000
79	MP0000372_irregular_coat_pigmentation	0.91605832
80	MP0005389_reproductive_system_phenotype	0.90415666
81	MP0002938_white_spotting	0.89193335
82	MP0006035_abnormal_mitochondrial_morpho	0.89145694
83	MP0001440_abnormal_grooming_behavior	0.88966915
84	MP0000538_abnormal_urinary_bladder	0.87774822
85	MP0002063_abnormal_learning/memory/cond	0.87347511
86	MP0008875_abnormal_xenobiotic_pharmacok	0.86750126
87	MP0002752_abnormal_somatic_nervous	0.85834292
88	MP0010678_abnormal_skin_adnexa	0.85523768
89	MP0002127_abnormal_cardiovascular_syste	0.85505902
90	MP0002733_abnormal_thermal_nociception	0.83954630
91	MP0000230_abnormal_systemic_arterial	0.82881509
92	MP0005195_abnormal_posterior_eye	0.81346441
93	MP0002909_abnormal_adrenal_gland	0.81256699
94	MP0001929_abnormal_gametogenesis	0.80793933
95	MP0002735_abnormal_chemical_nociception	0.80535909
96	MP0000049_abnormal_middle_ear	0.79930487
97	MP0002090_abnormal_vision	0.79152827
98	MP0004085_abnormal_heartbeat	0.78370471
99	MP0002254_reproductive_system_inflammat	0.78154095
100	MP0002282_abnormal_trachea_morphology	0.77906818

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.83623243
2	Pancreatic cysts (HP:0001737)	4.38011580
3	Medial flaring of the eyebrow (HP:0010747)	4.33298235
4	Pancreatic fibrosis (HP:0100732)	3.90302028
5	Nephronophthisis (HP:0000090)	3.83853956
6	Gait imbalance (HP:0002141)	3.70222970
7	Abnormality of midbrain morphology (HP:0002418)	3.51979107
8	Molar tooth sign on MRI (HP:0002419)	3.51979107
9	Congenital primary aphakia (HP:0007707)	3.43194506
10	Type II lissencephaly (HP:0007260)	3.21539162
11	Abnormality of the renal medulla (HP:0100957)	3.14828463
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.13108609
13	Concave nail (HP:0001598)	3.07727336
14	Nephrogenic diabetes insipidus (HP:0009806)	3.03025233
15	Abnormality of the renal cortex (HP:0011035)	2.94540687
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.88503979
17	3-Methylglutaconic aciduria (HP:0003535)	2.87355388
18	Cystic liver disease (HP:0006706)	2.80018865
19	Optic nerve hypoplasia (HP:0000609)	2.78439350
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.73281249
21	Renal cortical cysts (HP:0000803)	2.69565028
22	Male pseudohermaphroditism (HP:0000037)	2.68667217
23	Congenital stationary night blindness (HP:0007642)	2.67270338
24	Poor coordination (HP:0002370)	2.62288564
25	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.58713674
26	Febrile seizures (HP:0002373)	2.54164038
27	Hypothermia (HP:0002045)	2.53774868
28	Sclerocornea (HP:0000647)	2.48266842
29	Hyperventilation (HP:0002883)	2.45389231
30	Chronic hepatic failure (HP:0100626)	2.43239785
31	Short phalanx of the thumb (HP:0009660)	2.42862707
32	Neoplasm of the heart (HP:0100544)	2.42172105
33	Pigmentary retinal degeneration (HP:0001146)	2.40134146
34	Vaginal atresia (HP:0000148)	2.39991337
35	Hyperinsulinemic hypoglycemia (HP:0000825)	2.38425200
36	Genital tract atresia (HP:0001827)	2.35328724
37	Polyphagia (HP:0002591)	2.35304059
38	Acute necrotizing encephalopathy (HP:0006965)	2.33464269
39	Abnormal ciliary motility (HP:0012262)	2.30637886
40	Attenuation of retinal blood vessels (HP:0007843)	2.27461280
41	Acute encephalopathy (HP:0006846)	2.27214378
42	Progressive macrocephaly (HP:0004481)	2.25474315
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21636579
44	Hemiparesis (HP:0001269)	2.20958488
45	Mitochondrial inheritance (HP:0001427)	2.20544150
46	Abnormality of the labia minora (HP:0012880)	2.20420638
47	Aplasia/hypoplasia of the uterus (HP:0008684)	2.20059528
48	Atonic seizures (HP:0010819)	2.18507361
49	Congenital hepatic fibrosis (HP:0002612)	2.18061210
50	Hypoplasia of the uterus (HP:0000013)	2.16535690
51	Polydipsia (HP:0001959)	2.16336019
52	Abnormal drinking behavior (HP:0030082)	2.16336019
53	Thyroid-stimulating hormone excess (HP:0002925)	2.14043305
54	Tubulointerstitial nephritis (HP:0001970)	2.13962793
55	Specific learning disability (HP:0001328)	2.13892837
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13693924
57	Postaxial foot polydactyly (HP:0001830)	2.11502990
58	Tubular atrophy (HP:0000092)	2.11158755
59	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.07738727
60	Occipital encephalocele (HP:0002085)	2.07268789
61	Furrowed tongue (HP:0000221)	2.07132453
62	Gaze-evoked nystagmus (HP:0000640)	2.05474509
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.04453874
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.04453874
65	Increased CSF lactate (HP:0002490)	2.02752254
66	Cerebellar dysplasia (HP:0007033)	1.99216910
67	Calf muscle hypertrophy (HP:0008981)	1.98155325
68	Postaxial hand polydactyly (HP:0001162)	1.98015941
69	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.95262721
70	Decreased central vision (HP:0007663)	1.92965755
71	Chorioretinal atrophy (HP:0000533)	1.92824163
72	Absent/shortened dynein arms (HP:0200106)	1.92531020
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92531020
74	Hepatic necrosis (HP:0002605)	1.90410828
75	Retinal dysplasia (HP:0007973)	1.90006183
76	Thyroiditis (HP:0100646)	1.88091406
77	Hepatocellular necrosis (HP:0001404)	1.87566498
78	Progressive cerebellar ataxia (HP:0002073)	1.87402640
79	Anencephaly (HP:0002323)	1.86234630
80	Type I diabetes mellitus (HP:0100651)	1.86165071
81	Short 1st metacarpal (HP:0010034)	1.85983763
82	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.85983763
83	Bile duct proliferation (HP:0001408)	1.85690055
84	Abnormal biliary tract physiology (HP:0012439)	1.85690055
85	Intestinal atresia (HP:0011100)	1.84173991
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.81982125
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.81982125
88	Tongue fasciculations (HP:0001308)	1.81398178
89	Failure to thrive in infancy (HP:0001531)	1.79295793
90	Short chin (HP:0000331)	1.78153627
91	Poor suck (HP:0002033)	1.77757919
92	Central scotoma (HP:0000603)	1.76573397
93	Reduced antithrombin III activity (HP:0001976)	1.76518129
94	Gonadal dysgenesis (HP:0000133)	1.76036782
95	Rimmed vacuoles (HP:0003805)	1.74257587
96	Large for gestational age (HP:0001520)	1.73966755
97	Aplasia/Hypoplasia of the lens (HP:0008063)	1.73468333
98	Hypoglycemic coma (HP:0001325)	1.71861287
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.71540997
100	Muscle hypertrophy of the lower extremities (HP:0008968)	1.70910407

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.59934333
2	FRK	4.29385760
3	BCKDK	2.92340334
4	MAP2K7	2.61531786
5	MAPK13	2.46567240
6	ZAK	2.24598226
7	TAOK3	2.24283618
8	TRIM28	2.21022825
9	PHKG1	2.14122683
10	PHKG2	2.14122683
11	MAP3K4	2.07550358
12	VRK1	1.97618409
13	CASK	1.97172532
14	TNIK	1.91853580
15	WNK3	1.90654643
16	ADRBK2	1.77068006
17	MAP4K2	1.74799377
18	CSNK1G3	1.63963025
19	GRK1	1.62383543
20	BMPR1B	1.58953357
21	TLK1	1.56963694
22	CSNK1G1	1.52924686
23	CDK19	1.52584739
24	CSNK1A1L	1.46500339
25	VRK2	1.43252069
26	AKT3	1.42073814
27	CSNK1G2	1.41588422
28	OBSCN	1.40813917
29	DYRK2	1.38539240
30	MAPK15	1.37963024
31	NLK	1.34752601
32	GRK5	1.17139447
33	CAMKK2	1.13839469
34	KIT	1.07676719
35	BRSK2	1.07408865
36	DYRK3	1.06005892
37	PLK2	1.02426640
38	NME1	1.02088382
39	ARAF	0.96670044
40	MARK1	0.95376659
41	PTK2B	0.93464364
42	MAP2K4	0.90198987
43	TIE1	0.89647055
44	WEE1	0.88679378
45	MAP3K6	0.88103062
46	NUAK1	0.86033549
47	PRKCE	0.84242809
48	ADRBK1	0.84048046
49	OXSR1	0.83832725
50	TESK2	0.82896001
51	GRK6	0.82603554
52	PAK3	0.81809718
53	STK38L	0.80359782
54	PNCK	0.75362896
55	PRKCQ	0.73456084
56	TNK2	0.71575986
57	PKN1	0.70475202
58	EPHA4	0.70188611
59	MAPKAPK3	0.69785238
60	MAPKAPK5	0.68706364
61	PLK3	0.68586391
62	EIF2AK3	0.67971340
63	INSRR	0.67196892
64	PRKCG	0.66421373
65	MARK3	0.61492803
66	KDR	0.60485740
67	BCR	0.60103996
68	TEC	0.60000517
69	SGK2	0.56564786
70	PRKG2	0.52360447
71	ERBB3	0.51961226
72	PIM2	0.51319817
73	FGFR2	0.50720574
74	TXK	0.48932735
75	CAMK1	0.47613975
76	LMTK2	0.47058324
77	DYRK1A	0.46966814
78	FLT3	0.45843137
79	CDK3	0.45261730
80	NTRK3	0.45237950
81	RPS6KA5	0.44432426
82	NTRK2	0.44372113
83	STK24	0.43294185
84	EIF2AK2	0.42287528
85	PRKACA	0.41633470
86	PRKCI	0.38547566
87	DAPK2	0.38175506
88	GRK7	0.36896393
89	BLK	0.36743333
90	CSNK1A1	0.34448023
91	SGK223	0.32184874
92	SGK494	0.32184874
93	MYLK	0.31878748
94	TGFBR1	0.31591455
95	MAP2K6	0.31518332
96	SRPK1	0.30176752
97	RAF1	0.29545130
98	CAMK2A	0.29486271
99	PIK3CG	0.29034790
100	CSNK1D	0.27763333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.01424749
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.97159313
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.89993492
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.86716610
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79478696
6	Parkinsons disease_Homo sapiens_hsa05012	2.49129682
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.31083432
8	Phototransduction_Homo sapiens_hsa04744	2.21419497
9	Nicotine addiction_Homo sapiens_hsa05033	2.06913029
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91740448
11	Circadian rhythm_Homo sapiens_hsa04710	1.88812688
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.87624264
13	Protein export_Homo sapiens_hsa03060	1.84962038
14	Propanoate metabolism_Homo sapiens_hsa00640	1.70926568
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.68424855
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61539775
17	Olfactory transduction_Homo sapiens_hsa04740	1.60641117
18	Alzheimers disease_Homo sapiens_hsa05010	1.60401517
19	Regulation of autophagy_Homo sapiens_hsa04140	1.53828130
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50711613
21	ABC transporters_Homo sapiens_hsa02010	1.50327540
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47846839
23	Circadian entrainment_Homo sapiens_hsa04713	1.47533676
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47229591
25	Taste transduction_Homo sapiens_hsa04742	1.46786639
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.45584340
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45515546
28	Fatty acid elongation_Homo sapiens_hsa00062	1.40985859
29	Huntingtons disease_Homo sapiens_hsa05016	1.40887741
30	Homologous recombination_Homo sapiens_hsa03440	1.40469314
31	Morphine addiction_Homo sapiens_hsa05032	1.40109593
32	GABAergic synapse_Homo sapiens_hsa04727	1.39999262
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.36985781
34	Peroxisome_Homo sapiens_hsa04146	1.34223547
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.31031582
36	Caffeine metabolism_Homo sapiens_hsa00232	1.30368585
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.29990395
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.28289224
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26655998
40	RNA polymerase_Homo sapiens_hsa03020	1.21560282
41	Basal transcription factors_Homo sapiens_hsa03022	1.19946047
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.19853657
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15717601
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.06320314
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.05527975
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03744522
47	Basal cell carcinoma_Homo sapiens_hsa05217	1.01439655
48	Serotonergic synapse_Homo sapiens_hsa04726	0.98126557
49	Insulin secretion_Homo sapiens_hsa04911	0.95468945
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92978311
51	Purine metabolism_Homo sapiens_hsa00230	0.92706043
52	Salivary secretion_Homo sapiens_hsa04970	0.89757100
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88857756
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87379672
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86422123
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86356538
57	Proteasome_Homo sapiens_hsa03050	0.86172272
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.83212734
59	Alcoholism_Homo sapiens_hsa05034	0.83117264
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79233088
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77740857
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76953587
63	Retinol metabolism_Homo sapiens_hsa00830	0.75879850
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74546367
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74207055
66	Ribosome_Homo sapiens_hsa03010	0.72562803
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72485393
68	Renin secretion_Homo sapiens_hsa04924	0.70769030
69	Glutathione metabolism_Homo sapiens_hsa00480	0.69065744
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68066752
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66128557
72	RNA degradation_Homo sapiens_hsa03018	0.64735981
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.64550868
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64546299
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63833912
76	Fatty acid degradation_Homo sapiens_hsa00071	0.62680237
77	Metabolic pathways_Homo sapiens_hsa01100	0.58367187
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.57272221
79	Long-term depression_Homo sapiens_hsa04730	0.56341239
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56150893
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54809987
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.52548951
83	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.50876541
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49148665
85	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.48848542
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48827304
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47363844
88	Gap junction_Homo sapiens_hsa04540	0.47186521
89	Gastric acid secretion_Homo sapiens_hsa04971	0.46454726
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46415783
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.44313107
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.44226006
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.42994550
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.42562938
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42357142
96	Mineral absorption_Homo sapiens_hsa04978	0.37832799
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37216890
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36509393
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35868910
100	Bile secretion_Homo sapiens_hsa04976	0.34112334

TPTE2P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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