TPTE2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.30861973
2piRNA metabolic process (GO:0034587)4.95471342
3negative regulation of telomere maintenance (GO:0032205)4.73044707
4male meiosis (GO:0007140)4.02410266
5synapsis (GO:0007129)4.02052511
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.00067375
7NADH dehydrogenase complex assembly (GO:0010257)4.00067375
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.00067375
9L-fucose catabolic process (GO:0042355)3.79322212
10fucose catabolic process (GO:0019317)3.79322212
11L-fucose metabolic process (GO:0042354)3.79322212
12response to pheromone (GO:0019236)3.78540019
13male meiosis I (GO:0007141)3.76271150
14DNA deamination (GO:0045006)3.74716341
15protein complex biogenesis (GO:0070271)3.66283823
16behavioral response to ethanol (GO:0048149)3.63983800
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.61598473
18negative regulation of mast cell activation (GO:0033004)3.53040207
19gamma-aminobutyric acid transport (GO:0015812)3.50581922
20interkinetic nuclear migration (GO:0022027)3.49487636
21regulation of cilium movement (GO:0003352)3.48236695
22regulation of telomere maintenance via telomerase (GO:0032210)3.47342906
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47148000
24regulation of meiosis I (GO:0060631)3.45803001
25DNA methylation involved in gamete generation (GO:0043046)3.44569244
26cell wall macromolecule metabolic process (GO:0044036)3.43195888
27rRNA catabolic process (GO:0016075)3.38707982
28platelet dense granule organization (GO:0060155)3.32111879
29respiratory chain complex IV assembly (GO:0008535)3.30456836
30mitochondrial respiratory chain complex assembly (GO:0033108)3.27186056
31epithelial cilium movement (GO:0003351)3.25955427
32detection of light stimulus involved in visual perception (GO:0050908)3.23400709
33detection of light stimulus involved in sensory perception (GO:0050962)3.23400709
34axoneme assembly (GO:0035082)3.17068040
35regulation of telomere maintenance (GO:0032204)3.16438151
36indole-containing compound catabolic process (GO:0042436)3.13263957
37indolalkylamine catabolic process (GO:0046218)3.13263957
38tryptophan catabolic process (GO:0006569)3.13263957
39protein polyglutamylation (GO:0018095)3.10248388
40negative regulation of telomerase activity (GO:0051974)3.09213133
41cilium or flagellum-dependent cell motility (GO:0001539)3.01667522
42indolalkylamine metabolic process (GO:0006586)2.99082530
43phosphatidylinositol acyl-chain remodeling (GO:0036149)2.97248459
44reciprocal DNA recombination (GO:0035825)2.94147344
45reciprocal meiotic recombination (GO:0007131)2.94147344
46ubiquinone biosynthetic process (GO:0006744)2.89508565
47meiotic chromosome segregation (GO:0045132)2.88920880
48protein-cofactor linkage (GO:0018065)2.87836403
49dopamine transport (GO:0015872)2.87085941
50cilium morphogenesis (GO:0060271)2.85848328
51retinal cone cell development (GO:0046549)2.85717337
52multicellular organism reproduction (GO:0032504)2.85349149
53sperm motility (GO:0030317)2.80587197
54positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79276975
55meiosis I (GO:0007127)2.79260565
56water-soluble vitamin biosynthetic process (GO:0042364)2.77930272
57positive regulation of defense response to virus by host (GO:0002230)2.76418801
58neuronal action potential (GO:0019228)2.76193673
59cytochrome complex assembly (GO:0017004)2.75278840
60phosphatidylserine acyl-chain remodeling (GO:0036150)2.75001927
61cell wall macromolecule catabolic process (GO:0016998)2.71781222
62preassembly of GPI anchor in ER membrane (GO:0016254)2.70939667
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69878335
64sulfation (GO:0051923)2.69364574
65positive regulation of meiosis (GO:0045836)2.68513201
66regulation of rhodopsin mediated signaling pathway (GO:0022400)2.68205811
67cilium movement (GO:0003341)2.67403037
68rhodopsin mediated signaling pathway (GO:0016056)2.66613633
69photoreceptor cell maintenance (GO:0045494)2.64003329
70regulation of microtubule-based movement (GO:0060632)2.61661272
71protein neddylation (GO:0045116)2.59705263
72centriole replication (GO:0007099)2.58328680
73ubiquinone metabolic process (GO:0006743)2.58249264
74positive regulation of fatty acid transport (GO:2000193)2.57084381
75positive regulation of meiotic cell cycle (GO:0051446)2.53396775
76polyol catabolic process (GO:0046174)2.52901276
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.52878822
78cornea development in camera-type eye (GO:0061303)2.52628798
79neural tube formation (GO:0001841)2.50828101
80tryptophan metabolic process (GO:0006568)2.49589158
81cellular biogenic amine catabolic process (GO:0042402)2.48503641
82amine catabolic process (GO:0009310)2.48503641
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48263601
84chromosome organization involved in meiosis (GO:0070192)2.47919514
85protein localization to cilium (GO:0061512)2.47115889
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45842863
87cAMP catabolic process (GO:0006198)2.44841702
88cellular ketone body metabolic process (GO:0046950)2.44002080
89cilium organization (GO:0044782)2.43833833
90regulation of action potential (GO:0098900)2.43046539
91kynurenine metabolic process (GO:0070189)2.42989064
92double-strand break repair via homologous recombination (GO:0000724)2.42338830
93replication fork processing (GO:0031297)2.41296333
94inositol phosphate catabolic process (GO:0071545)2.40964034
95cellular response to ATP (GO:0071318)2.40934520
96recombinational repair (GO:0000725)2.40433208
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40240757
98positive regulation of prostaglandin secretion (GO:0032308)2.40207897
99meiotic nuclear division (GO:0007126)2.39929742
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38962166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.85724593
2VDR_22108803_ChIP-Seq_LS180_Human3.81285884
3GBX2_23144817_ChIP-Seq_PC3_Human3.17664198
4EZH2_22144423_ChIP-Seq_EOC_Human3.02694356
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64363483
6FUS_26573619_Chip-Seq_HEK293_Human2.45920608
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38766316
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36127506
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29639846
10IGF1R_20145208_ChIP-Seq_DFB_Human2.28539216
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25845688
12EWS_26573619_Chip-Seq_HEK293_Human2.18294144
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17422156
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10181385
15P300_19829295_ChIP-Seq_ESCs_Human1.98905296
16TAF15_26573619_Chip-Seq_HEK293_Human1.98641210
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.97310224
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95214211
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95020301
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90860319
21ER_23166858_ChIP-Seq_MCF-7_Human1.85923589
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79321851
23TP53_22573176_ChIP-Seq_HFKS_Human1.66419406
24GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.62673329
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61993774
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60922388
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59541131
28BCAT_22108803_ChIP-Seq_LS180_Human1.58651727
29STAT3_23295773_ChIP-Seq_U87_Human1.57058867
30MYC_18940864_ChIP-ChIP_HL60_Human1.56773875
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55818231
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55076786
33CBP_20019798_ChIP-Seq_JUKART_Human1.55076786
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54765392
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54674637
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54444454
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53339395
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52718740
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51462964
40IRF1_19129219_ChIP-ChIP_H3396_Human1.48533269
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48493973
42TCF4_23295773_ChIP-Seq_U87_Human1.43505962
43SMAD4_21799915_ChIP-Seq_A2780_Human1.42159547
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.40422472
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39820761
46AR_25329375_ChIP-Seq_VCAP_Human1.39061016
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37522422
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37265472
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37265472
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.36924921
51NANOG_19829295_ChIP-Seq_ESCs_Human1.34540860
52SOX2_19829295_ChIP-Seq_ESCs_Human1.34540860
53REST_21632747_ChIP-Seq_MESCs_Mouse1.34165437
54AR_20517297_ChIP-Seq_VCAP_Human1.33557456
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32814158
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.32814158
57RUNX2_22187159_ChIP-Seq_PCA_Human1.32023801
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31994218
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.30888712
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28211237
61NCOR_22424771_ChIP-Seq_293T_Human1.28128309
62RNF2_27304074_Chip-Seq_NSC_Mouse1.28035794
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.27160379
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26684969
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25494613
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25016364
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23048514
68TCF4_22108803_ChIP-Seq_LS180_Human1.22128167
69TP53_16413492_ChIP-PET_HCT116_Human1.22061425
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21757753
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.20778882
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.19893095
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.18667747
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17694269
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.17223674
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16824662
77HOXB7_26014856_ChIP-Seq_BT474_Human1.16224143
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.13923315
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.12710126
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.12258224
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.10081891
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09101244
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08787227
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07331785
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.06810102
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05943196
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03285665
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02839661
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01734862
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01017545
91NANOG_20526341_ChIP-Seq_ESCs_Human1.00378117
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.99935874
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99303538
94MYC_19829295_ChIP-Seq_ESCs_Human0.99249503
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.97271197
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.96901443
97CDX2_22108803_ChIP-Seq_LS180_Human0.96729648
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95958294
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95487142
100AR_21572438_ChIP-Seq_LNCaP_Human0.94800675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.43700722
2MP0002102_abnormal_ear_morphology3.17256614
3MP0006292_abnormal_olfactory_placode2.70671797
4MP0005551_abnormal_eye_electrophysiolog2.68899803
5MP0002163_abnormal_gland_morphology2.51970041
6MP0006072_abnormal_retinal_apoptosis2.40680493
7MP0003787_abnormal_imprinting2.24849805
8MP0000372_irregular_coat_pigmentation2.23181017
9MP0003136_yellow_coat_color2.19267762
10MP0004147_increased_porphyrin_level2.13674071
11MP0005646_abnormal_pituitary_gland2.13655074
12MP0004133_heterotaxia2.03224601
13MP0000569_abnormal_digit_pigmentation2.03030543
14MP0002938_white_spotting2.01203329
15MP0001968_abnormal_touch/_nociception2.00733573
16MP0009046_muscle_twitch1.99140367
17MP0008875_abnormal_xenobiotic_pharmacok1.90134644
18MP0003880_abnormal_central_pattern1.89375981
19MP0008872_abnormal_physiological_respon1.87209240
20MP0005174_abnormal_tail_pigmentation1.84748717
21MP0003283_abnormal_digestive_organ1.82203162
22MP0002272_abnormal_nervous_system1.79557273
23MP0009745_abnormal_behavioral_response1.78344327
24MP0001986_abnormal_taste_sensitivity1.76839292
25MP0004142_abnormal_muscle_tone1.75795844
26MP0005253_abnormal_eye_physiology1.75599380
27MP0002638_abnormal_pupillary_reflex1.73432259
28MP0001501_abnormal_sleep_pattern1.67334366
29MP0006276_abnormal_autonomic_nervous1.66905369
30MP0005645_abnormal_hypothalamus_physiol1.64157478
31MP0005379_endocrine/exocrine_gland_phen1.63933016
32MP0005084_abnormal_gallbladder_morpholo1.62870332
33MP0002736_abnormal_nociception_after1.58970899
34MP0000631_abnormal_neuroendocrine_gland1.58225127
35MP0008775_abnormal_heart_ventricle1.57631450
36MP0001485_abnormal_pinna_reflex1.54332127
37MP0002837_dystrophic_cardiac_calcinosis1.46750903
38MP0003195_calcinosis1.44651852
39MP0002653_abnormal_ependyma_morphology1.41537246
40MP0002876_abnormal_thyroid_physiology1.41365432
41MP0003011_delayed_dark_adaptation1.38771184
42MP0003646_muscle_fatigue1.37747153
43MP0002160_abnormal_reproductive_system1.36466712
44MP0008058_abnormal_DNA_repair1.36196145
45MP0005410_abnormal_fertilization1.28565284
46MP0004885_abnormal_endolymph1.28423033
47MP0002572_abnormal_emotion/affect_behav1.24462097
48MP0001984_abnormal_olfaction1.22327884
49MP0003698_abnormal_male_reproductive1.18643667
50MP0001486_abnormal_startle_reflex1.16900954
51MP0005389_reproductive_system_phenotype1.14812105
52MP0000427_abnormal_hair_cycle1.14779777
53MP0005671_abnormal_response_to1.10721985
54MP0005195_abnormal_posterior_eye1.10175385
55MP0003635_abnormal_synaptic_transmissio1.10062145
56MP0001929_abnormal_gametogenesis1.08639476
57MP0002064_seizures1.07922707
58MP0002210_abnormal_sex_determination1.07545365
59MP0005075_abnormal_melanosome_morpholog1.05624661
60MP0000230_abnormal_systemic_arterial1.04763786
61MP0002557_abnormal_social/conspecific_i1.02945186
62MP0002138_abnormal_hepatobiliary_system1.02875543
63MP0001188_hyperpigmentation1.02336117
64MP0001905_abnormal_dopamine_level1.01799057
65MP0002733_abnormal_thermal_nociception1.01490049
66MP0002928_abnormal_bile_duct1.00970138
67MP0000015_abnormal_ear_pigmentation1.00746333
68MP0008789_abnormal_olfactory_epithelium1.00570578
69MP0002735_abnormal_chemical_nociception0.99439856
70MP0008995_early_reproductive_senescence0.98967968
71MP0005386_behavior/neurological_phenoty0.97682730
72MP0004924_abnormal_behavior0.97682730
73MP0001970_abnormal_pain_threshold0.97253839
74MP0000383_abnormal_hair_follicle0.96684916
75MP0002751_abnormal_autonomic_nervous0.96379784
76MP0001529_abnormal_vocalization0.95934610
77MP0002063_abnormal_learning/memory/cond0.94444938
78MP0004742_abnormal_vestibular_system0.93913324
79MP0002067_abnormal_sensory_capabilities0.91878300
80MP0002095_abnormal_skin_pigmentation0.89625771
81MP0002734_abnormal_mechanical_nocicepti0.88996902
82MP0003718_maternal_effect0.86739227
83MP0002184_abnormal_innervation0.85403169
84MP0009764_decreased_sensitivity_to0.84748389
85MP0002752_abnormal_somatic_nervous0.82472307
86MP0000653_abnormal_sex_gland0.82368446
87MP0002234_abnormal_pharynx_morphology0.81580922
88MP0001764_abnormal_homeostasis0.81370152
89MP0001145_abnormal_male_reproductive0.80937284
90MP0005332_abnormal_amino_acid0.80907133
91MP0000647_abnormal_sebaceous_gland0.78015669
92MP0003119_abnormal_digestive_system0.77543194
93MP0000566_synostosis0.76230642
94MP0003890_abnormal_embryonic-extraembry0.75979907
95MP0002229_neurodegeneration0.75910776
96MP0003121_genomic_imprinting0.75589352
97MP0010386_abnormal_urinary_bladder0.74978707
98MP0005167_abnormal_blood-brain_barrier0.73886902
99MP0009780_abnormal_chondrocyte_physiolo0.73290223
100MP0000049_abnormal_middle_ear0.73139786

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.26957672
2Abnormality of midbrain morphology (HP:0002418)4.25151791
3Molar tooth sign on MRI (HP:0002419)4.25151791
4Type II lissencephaly (HP:0007260)4.17136962
5Congenital stationary night blindness (HP:0007642)3.98473140
6Pancreatic fibrosis (HP:0100732)3.86420766
7Nephronophthisis (HP:0000090)3.78319430
8True hermaphroditism (HP:0010459)3.69344391
9Abolished electroretinogram (ERG) (HP:0000550)3.30128104
10Cerebellar dysplasia (HP:0007033)3.28933910
11Inability to walk (HP:0002540)3.18885605
12Abnormality of the renal medulla (HP:0100957)3.12557831
13Hypoplasia of the pons (HP:0012110)3.02808631
14Abnormality of the pons (HP:0007361)2.94654059
15Abnormality of the renal cortex (HP:0011035)2.93439127
16Medial flaring of the eyebrow (HP:0010747)2.90697793
17Progressive inability to walk (HP:0002505)2.83064520
18Chronic hepatic failure (HP:0100626)2.77801153
19Retinal dysplasia (HP:0007973)2.75366236
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.71918848
21Hyperventilation (HP:0002883)2.64885358
22Attenuation of retinal blood vessels (HP:0007843)2.60373649
23Oligodactyly (hands) (HP:0001180)2.56757609
24Cystic liver disease (HP:0006706)2.52166833
25Febrile seizures (HP:0002373)2.49643554
26Bile duct proliferation (HP:0001408)2.40116631
27Abnormal biliary tract physiology (HP:0012439)2.40116631
28Lissencephaly (HP:0001339)2.32169332
29Renal cortical cysts (HP:0000803)2.30003235
30Polydipsia (HP:0001959)2.29508676
31Abnormal drinking behavior (HP:0030082)2.29508676
32Sclerocornea (HP:0000647)2.28173773
33Abnormality of DNA repair (HP:0003254)2.28032582
34Retinal atrophy (HP:0001105)2.27242576
35Gaze-evoked nystagmus (HP:0000640)2.26454555
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.24477696
37Absent/shortened dynein arms (HP:0200106)2.24477696
38Acute necrotizing encephalopathy (HP:0006965)2.23571083
39Gait imbalance (HP:0002141)2.20628240
40Abnormal rod and cone electroretinograms (HP:0008323)2.20340301
41Pachygyria (HP:0001302)2.17680526
42Concave nail (HP:0001598)2.16969208
43Postaxial foot polydactyly (HP:0001830)2.14961609
44Tubular atrophy (HP:0000092)2.13706618
45Esophageal atresia (HP:0002032)2.13289241
46Anencephaly (HP:0002323)2.13171218
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12592843
48Abnormality of alanine metabolism (HP:0010916)2.12592843
49Hyperalaninemia (HP:0003348)2.12592843
50Congenital, generalized hypertrichosis (HP:0004540)2.12407931
51Increased CSF lactate (HP:0002490)2.11792159
52Congenital hepatic fibrosis (HP:0002612)2.10961032
53Congenital primary aphakia (HP:0007707)2.10249397
54Optic disc pallor (HP:0000543)2.09257260
55Progressive macrocephaly (HP:0004481)2.08222893
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.07478044
57Optic nerve hypoplasia (HP:0000609)2.07424809
58Mitochondrial inheritance (HP:0001427)2.05660160
59Male pseudohermaphroditism (HP:0000037)2.04582000
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.04349063
61Abnormal respiratory epithelium morphology (HP:0012253)2.02342800
62Abnormal respiratory motile cilium morphology (HP:0005938)2.02342800
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01995614
64Atonic seizures (HP:0010819)2.01377591
65Severe muscular hypotonia (HP:0006829)2.01127915
66Acute encephalopathy (HP:0006846)2.00688263
673-Methylglutaconic aciduria (HP:0003535)1.98410733
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97916493
69Pendular nystagmus (HP:0012043)1.96235207
70Furrowed tongue (HP:0000221)1.95426917
71Abnormality of the renal collecting system (HP:0004742)1.92035029
72Nephrogenic diabetes insipidus (HP:0009806)1.91173241
73Polyuria (HP:0000103)1.88840451
74Hepatocellular necrosis (HP:0001404)1.86808269
75Decreased central vision (HP:0007663)1.85617742
76Abnormal ciliary motility (HP:0012262)1.82217340
77Focal motor seizures (HP:0011153)1.80110793
78Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79779454
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.79429405
80Aplasia/hypoplasia of the uterus (HP:0008684)1.78678658
81Abnormal mitochondria in muscle tissue (HP:0008316)1.78295126
82Clumsiness (HP:0002312)1.77107977
83Broad-based gait (HP:0002136)1.76974849
84Hypothermia (HP:0002045)1.76568414
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76444425
86Tachypnea (HP:0002789)1.75861196
87Increased corneal curvature (HP:0100692)1.74002458
88Keratoconus (HP:0000563)1.74002458
89Hemiparesis (HP:0001269)1.72506436
90Preaxial hand polydactyly (HP:0001177)1.71723760
91Gastrointestinal atresia (HP:0002589)1.70719175
92Genital tract atresia (HP:0001827)1.70580893
93Protruding tongue (HP:0010808)1.70578571
94Hepatic necrosis (HP:0002605)1.70154317
95Absent thumb (HP:0009777)1.69576961
96Meckel diverticulum (HP:0002245)1.69484062
97Abnormality of the ileum (HP:0001549)1.68950309
98Postaxial hand polydactyly (HP:0001162)1.68746279
99Hypoplasia of the fovea (HP:0007750)1.68542811
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.68542811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.55700691
2TLK13.70432334
3MAP4K23.31673051
4ADRBK22.97772008
5PINK12.96767509
6ZAK2.72396928
7GRK12.59105196
8WNK32.31135886
9TAOK32.27402302
10BMPR1B2.14576497
11TAOK22.11537775
12NUAK12.02111953
13TXK2.01595361
14TIE11.93476795
15MAPK131.92800745
16WNK41.84492344
17OXSR11.81284524
18MAP3K41.74047331
19MAPKAPK31.72628131
20MAP2K61.68825570
21MARK31.64650291
22ACVR1B1.47247446
23STK391.44188811
24NEK21.41900391
25CDK191.30736785
26INSRR1.30662384
27MST41.28608620
28PTK2B1.24286029
29NME11.16348051
30SIK21.15347901
31PLK41.13775161
32ADRBK11.13731352
33CASK1.11586309
34NEK11.03599338
35PLK21.01865379
36MUSK1.00839338
37TNIK1.00555720
38TEC0.94761713
39STK38L0.94716287
40DYRK20.93774067
41CSNK1G20.90634955
42BCKDK0.90627781
43PRKCG0.84334917
44MAPKAPK50.83502450
45MAP2K70.81802822
46MAP3K50.81453116
47PRKCQ0.81297312
48PRKCE0.80409063
49CSNK1G30.79988033
50CAMKK20.78627433
51STK30.77483970
52MARK10.72846202
53DAPK20.72735247
54CSNK1G10.71814060
55PNCK0.68076490
56PAK30.67976244
57KIT0.67335333
58PIK3CA0.66449888
59EIF2AK30.66173422
60NTRK20.63619804
61STK110.62347783
62IKBKB0.59322162
63FGFR20.58773280
64CSNK1A1L0.57599081
65PHKG20.56436464
66PHKG10.56436464
67RPS6KA50.55827210
68FLT30.55427900
69TNK20.47271526
70CAMK2A0.46630285
71CSNK1A10.46105638
72NTRK30.43945421
73TGFBR10.43781612
74PKN10.43289079
75VRK10.40464239
76TRIM280.38920561
77IGF1R0.38860834
78DYRK30.38807243
79BRSK20.38629950
80GRK50.38390942
81STK100.38113909
82IRAK10.37181903
83TRPM70.36700354
84PRKACA0.35831342
85PRKCA0.34767756
86FER0.34501617
87CCNB10.34476087
88MAP2K20.32384700
89OBSCN0.32059946
90SYK0.32053639
91CSNK1D0.31488610
92DYRK1A0.31115489
93CSF1R0.30290414
94PRKG10.30012413
95PLK30.29726174
96ITK0.28961356
97CDK30.27881811
98ATR0.27410443
99CAMK10.27307347
100PLK10.26465983

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.07636854
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87549021
3Linoleic acid metabolism_Homo sapiens_hsa005912.86930767
4Nitrogen metabolism_Homo sapiens_hsa009102.67957293
5Butanoate metabolism_Homo sapiens_hsa006502.13920107
6Nicotine addiction_Homo sapiens_hsa050332.13465752
7Selenocompound metabolism_Homo sapiens_hsa004502.10308937
8Homologous recombination_Homo sapiens_hsa034402.07875656
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.97781821
10Asthma_Homo sapiens_hsa053101.93098832
11Regulation of autophagy_Homo sapiens_hsa041401.85773818
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84343650
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83183305
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82144832
15Fanconi anemia pathway_Homo sapiens_hsa034601.82106475
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81533481
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80462587
18Oxidative phosphorylation_Homo sapiens_hsa001901.78440169
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78317666
20Ether lipid metabolism_Homo sapiens_hsa005651.78120559
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76037047
22Basal transcription factors_Homo sapiens_hsa030221.73214086
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58504189
24Parkinsons disease_Homo sapiens_hsa050121.49837701
25Olfactory transduction_Homo sapiens_hsa047401.49832836
26Allograft rejection_Homo sapiens_hsa053301.48631096
27Graft-versus-host disease_Homo sapiens_hsa053321.42931871
28Type I diabetes mellitus_Homo sapiens_hsa049401.41553897
29Arachidonic acid metabolism_Homo sapiens_hsa005901.32461588
30Taste transduction_Homo sapiens_hsa047421.31284292
31Tryptophan metabolism_Homo sapiens_hsa003801.29806458
32Autoimmune thyroid disease_Homo sapiens_hsa053201.24627921
33Propanoate metabolism_Homo sapiens_hsa006401.22990544
34Chemical carcinogenesis_Homo sapiens_hsa052041.22035193
35Morphine addiction_Homo sapiens_hsa050321.21297080
36RNA polymerase_Homo sapiens_hsa030201.16963304
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13215032
38Caffeine metabolism_Homo sapiens_hsa002321.11432339
39One carbon pool by folate_Homo sapiens_hsa006701.07895710
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05216647
41Peroxisome_Homo sapiens_hsa041461.05129570
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.04121026
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.98885675
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98380133
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97001281
46Cardiac muscle contraction_Homo sapiens_hsa042600.96859271
47Circadian entrainment_Homo sapiens_hsa047130.95013086
48RNA degradation_Homo sapiens_hsa030180.94902239
49Fat digestion and absorption_Homo sapiens_hsa049750.92544588
50Protein export_Homo sapiens_hsa030600.91906207
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91301782
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91178785
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90547070
54Retinol metabolism_Homo sapiens_hsa008300.89372193
55Huntingtons disease_Homo sapiens_hsa050160.88985007
56GABAergic synapse_Homo sapiens_hsa047270.87832453
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87815340
58beta-Alanine metabolism_Homo sapiens_hsa004100.86656009
59Salivary secretion_Homo sapiens_hsa049700.84594526
60Serotonergic synapse_Homo sapiens_hsa047260.82667473
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80977247
62Purine metabolism_Homo sapiens_hsa002300.80932394
63Glutamatergic synapse_Homo sapiens_hsa047240.79691743
64Alzheimers disease_Homo sapiens_hsa050100.78446420
65Calcium signaling pathway_Homo sapiens_hsa040200.74772902
66Rheumatoid arthritis_Homo sapiens_hsa053230.73582794
67Collecting duct acid secretion_Homo sapiens_hsa049660.71590216
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70366656
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68498200
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.67654306
71Fatty acid biosynthesis_Homo sapiens_hsa000610.65960548
72Insulin secretion_Homo sapiens_hsa049110.65731863
73Pyrimidine metabolism_Homo sapiens_hsa002400.65167089
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65085892
75ABC transporters_Homo sapiens_hsa020100.64306842
76Ovarian steroidogenesis_Homo sapiens_hsa049130.64141828
77Steroid biosynthesis_Homo sapiens_hsa001000.62287390
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.62177435
79Glycerolipid metabolism_Homo sapiens_hsa005610.61566165
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60432354
81Ribosome_Homo sapiens_hsa030100.59319559
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.57602462
83Dorso-ventral axis formation_Homo sapiens_hsa043200.53546881
84Primary immunodeficiency_Homo sapiens_hsa053400.52922226
85Antigen processing and presentation_Homo sapiens_hsa046120.52827007
86Long-term depression_Homo sapiens_hsa047300.52539705
87Fatty acid elongation_Homo sapiens_hsa000620.50145056
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47396805
89Metabolic pathways_Homo sapiens_hsa011000.46565246
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46429703
91Cocaine addiction_Homo sapiens_hsa050300.44928942
92Fatty acid degradation_Homo sapiens_hsa000710.44509872
93Fatty acid metabolism_Homo sapiens_hsa012120.43943701
94Nucleotide excision repair_Homo sapiens_hsa034200.41638313
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40857935
96Gastric acid secretion_Homo sapiens_hsa049710.40085657
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39734865
98Oxytocin signaling pathway_Homo sapiens_hsa049210.38893704
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37940165
100Sulfur metabolism_Homo sapiens_hsa009200.37462981

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