ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.30861973
2	piRNA metabolic process (GO:0034587)	4.95471342
3	negative regulation of telomere maintenance (GO:0032205)	4.73044707
4	male meiosis (GO:0007140)	4.02410266
5	synapsis (GO:0007129)	4.02052511
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.00067375
7	NADH dehydrogenase complex assembly (GO:0010257)	4.00067375
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.00067375
9	L-fucose catabolic process (GO:0042355)	3.79322212
10	fucose catabolic process (GO:0019317)	3.79322212
11	L-fucose metabolic process (GO:0042354)	3.79322212
12	response to pheromone (GO:0019236)	3.78540019
13	male meiosis I (GO:0007141)	3.76271150
14	DNA deamination (GO:0045006)	3.74716341
15	protein complex biogenesis (GO:0070271)	3.66283823
16	behavioral response to ethanol (GO:0048149)	3.63983800
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.61598473
18	negative regulation of mast cell activation (GO:0033004)	3.53040207
19	gamma-aminobutyric acid transport (GO:0015812)	3.50581922
20	interkinetic nuclear migration (GO:0022027)	3.49487636
21	regulation of cilium movement (GO:0003352)	3.48236695
22	regulation of telomere maintenance via telomerase (GO:0032210)	3.47342906
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47148000
24	regulation of meiosis I (GO:0060631)	3.45803001
25	DNA methylation involved in gamete generation (GO:0043046)	3.44569244
26	cell wall macromolecule metabolic process (GO:0044036)	3.43195888
27	rRNA catabolic process (GO:0016075)	3.38707982
28	platelet dense granule organization (GO:0060155)	3.32111879
29	respiratory chain complex IV assembly (GO:0008535)	3.30456836
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.27186056
31	epithelial cilium movement (GO:0003351)	3.25955427
32	detection of light stimulus involved in visual perception (GO:0050908)	3.23400709
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.23400709
34	axoneme assembly (GO:0035082)	3.17068040
35	regulation of telomere maintenance (GO:0032204)	3.16438151
36	indole-containing compound catabolic process (GO:0042436)	3.13263957
37	indolalkylamine catabolic process (GO:0046218)	3.13263957
38	tryptophan catabolic process (GO:0006569)	3.13263957
39	protein polyglutamylation (GO:0018095)	3.10248388
40	negative regulation of telomerase activity (GO:0051974)	3.09213133
41	cilium or flagellum-dependent cell motility (GO:0001539)	3.01667522
42	indolalkylamine metabolic process (GO:0006586)	2.99082530
43	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.97248459
44	reciprocal DNA recombination (GO:0035825)	2.94147344
45	reciprocal meiotic recombination (GO:0007131)	2.94147344
46	ubiquinone biosynthetic process (GO:0006744)	2.89508565
47	meiotic chromosome segregation (GO:0045132)	2.88920880
48	protein-cofactor linkage (GO:0018065)	2.87836403
49	dopamine transport (GO:0015872)	2.87085941
50	cilium morphogenesis (GO:0060271)	2.85848328
51	retinal cone cell development (GO:0046549)	2.85717337
52	multicellular organism reproduction (GO:0032504)	2.85349149
53	sperm motility (GO:0030317)	2.80587197
54	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.79276975
55	meiosis I (GO:0007127)	2.79260565
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.77930272
57	positive regulation of defense response to virus by host (GO:0002230)	2.76418801
58	neuronal action potential (GO:0019228)	2.76193673
59	cytochrome complex assembly (GO:0017004)	2.75278840
60	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.75001927
61	cell wall macromolecule catabolic process (GO:0016998)	2.71781222
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70939667
63	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.69878335
64	sulfation (GO:0051923)	2.69364574
65	positive regulation of meiosis (GO:0045836)	2.68513201
66	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.68205811
67	cilium movement (GO:0003341)	2.67403037
68	rhodopsin mediated signaling pathway (GO:0016056)	2.66613633
69	photoreceptor cell maintenance (GO:0045494)	2.64003329
70	regulation of microtubule-based movement (GO:0060632)	2.61661272
71	protein neddylation (GO:0045116)	2.59705263
72	centriole replication (GO:0007099)	2.58328680
73	ubiquinone metabolic process (GO:0006743)	2.58249264
74	positive regulation of fatty acid transport (GO:2000193)	2.57084381
75	positive regulation of meiotic cell cycle (GO:0051446)	2.53396775
76	polyol catabolic process (GO:0046174)	2.52901276
77	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52878822
78	cornea development in camera-type eye (GO:0061303)	2.52628798
79	neural tube formation (GO:0001841)	2.50828101
80	tryptophan metabolic process (GO:0006568)	2.49589158
81	cellular biogenic amine catabolic process (GO:0042402)	2.48503641
82	amine catabolic process (GO:0009310)	2.48503641
83	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.48263601
84	chromosome organization involved in meiosis (GO:0070192)	2.47919514
85	protein localization to cilium (GO:0061512)	2.47115889
86	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.45842863
87	cAMP catabolic process (GO:0006198)	2.44841702
88	cellular ketone body metabolic process (GO:0046950)	2.44002080
89	cilium organization (GO:0044782)	2.43833833
90	regulation of action potential (GO:0098900)	2.43046539
91	kynurenine metabolic process (GO:0070189)	2.42989064
92	double-strand break repair via homologous recombination (GO:0000724)	2.42338830
93	replication fork processing (GO:0031297)	2.41296333
94	inositol phosphate catabolic process (GO:0071545)	2.40964034
95	cellular response to ATP (GO:0071318)	2.40934520
96	recombinational repair (GO:0000725)	2.40433208
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.40240757
98	positive regulation of prostaglandin secretion (GO:0032308)	2.40207897
99	meiotic nuclear division (GO:0007126)	2.39929742
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.38962166

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85724593
2	VDR_22108803_ChIP-Seq_LS180_Human	3.81285884
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.17664198
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.02694356
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64363483
6	FUS_26573619_Chip-Seq_HEK293_Human	2.45920608
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38766316
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36127506
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29639846
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28539216
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25845688
12	EWS_26573619_Chip-Seq_HEK293_Human	2.18294144
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17422156
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10181385
15	P300_19829295_ChIP-Seq_ESCs_Human	1.98905296
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.98641210
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97310224
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95214211
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95020301
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90860319
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.85923589
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79321851
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.66419406
24	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.62673329
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.61993774
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60922388
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59541131
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.58651727
29	STAT3_23295773_ChIP-Seq_U87_Human	1.57058867
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.56773875
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55818231
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55076786
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.55076786
34	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54765392
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.54674637
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.54444454
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53339395
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52718740
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51462964
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48533269
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48493973
42	TCF4_23295773_ChIP-Seq_U87_Human	1.43505962
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42159547
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40422472
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39820761
46	AR_25329375_ChIP-Seq_VCAP_Human	1.39061016
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37522422
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37265472
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37265472
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36924921
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34540860
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34540860
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34165437
54	AR_20517297_ChIP-Seq_VCAP_Human	1.33557456
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32814158
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32814158
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32023801
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31994218
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30888712
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28211237
61	NCOR_22424771_ChIP-Seq_293T_Human	1.28128309
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28035794
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27160379
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26684969
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25494613
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25016364
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23048514
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.22128167
69	TP53_16413492_ChIP-PET_HCT116_Human	1.22061425
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21757753
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20778882
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19893095
73	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.18667747
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17694269
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17223674
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16824662
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16224143
78	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.13923315
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12710126
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12258224
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10081891
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09101244
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08787227
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07331785
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06810102
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05943196
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03285665
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02839661
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01734862
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01017545
91	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00378117
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99935874
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99303538
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.99249503
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97271197
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96901443
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.96729648
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95958294
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95487142
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.94800675

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.43700722
2	MP0002102_abnormal_ear_morphology	3.17256614
3	MP0006292_abnormal_olfactory_placode	2.70671797
4	MP0005551_abnormal_eye_electrophysiolog	2.68899803
5	MP0002163_abnormal_gland_morphology	2.51970041
6	MP0006072_abnormal_retinal_apoptosis	2.40680493
7	MP0003787_abnormal_imprinting	2.24849805
8	MP0000372_irregular_coat_pigmentation	2.23181017
9	MP0003136_yellow_coat_color	2.19267762
10	MP0004147_increased_porphyrin_level	2.13674071
11	MP0005646_abnormal_pituitary_gland	2.13655074
12	MP0004133_heterotaxia	2.03224601
13	MP0000569_abnormal_digit_pigmentation	2.03030543
14	MP0002938_white_spotting	2.01203329
15	MP0001968_abnormal_touch/_nociception	2.00733573
16	MP0009046_muscle_twitch	1.99140367
17	MP0008875_abnormal_xenobiotic_pharmacok	1.90134644
18	MP0003880_abnormal_central_pattern	1.89375981
19	MP0008872_abnormal_physiological_respon	1.87209240
20	MP0005174_abnormal_tail_pigmentation	1.84748717
21	MP0003283_abnormal_digestive_organ	1.82203162
22	MP0002272_abnormal_nervous_system	1.79557273
23	MP0009745_abnormal_behavioral_response	1.78344327
24	MP0001986_abnormal_taste_sensitivity	1.76839292
25	MP0004142_abnormal_muscle_tone	1.75795844
26	MP0005253_abnormal_eye_physiology	1.75599380
27	MP0002638_abnormal_pupillary_reflex	1.73432259
28	MP0001501_abnormal_sleep_pattern	1.67334366
29	MP0006276_abnormal_autonomic_nervous	1.66905369
30	MP0005645_abnormal_hypothalamus_physiol	1.64157478
31	MP0005379_endocrine/exocrine_gland_phen	1.63933016
32	MP0005084_abnormal_gallbladder_morpholo	1.62870332
33	MP0002736_abnormal_nociception_after	1.58970899
34	MP0000631_abnormal_neuroendocrine_gland	1.58225127
35	MP0008775_abnormal_heart_ventricle	1.57631450
36	MP0001485_abnormal_pinna_reflex	1.54332127
37	MP0002837_dystrophic_cardiac_calcinosis	1.46750903
38	MP0003195_calcinosis	1.44651852
39	MP0002653_abnormal_ependyma_morphology	1.41537246
40	MP0002876_abnormal_thyroid_physiology	1.41365432
41	MP0003011_delayed_dark_adaptation	1.38771184
42	MP0003646_muscle_fatigue	1.37747153
43	MP0002160_abnormal_reproductive_system	1.36466712
44	MP0008058_abnormal_DNA_repair	1.36196145
45	MP0005410_abnormal_fertilization	1.28565284
46	MP0004885_abnormal_endolymph	1.28423033
47	MP0002572_abnormal_emotion/affect_behav	1.24462097
48	MP0001984_abnormal_olfaction	1.22327884
49	MP0003698_abnormal_male_reproductive	1.18643667
50	MP0001486_abnormal_startle_reflex	1.16900954
51	MP0005389_reproductive_system_phenotype	1.14812105
52	MP0000427_abnormal_hair_cycle	1.14779777
53	MP0005671_abnormal_response_to	1.10721985
54	MP0005195_abnormal_posterior_eye	1.10175385
55	MP0003635_abnormal_synaptic_transmissio	1.10062145
56	MP0001929_abnormal_gametogenesis	1.08639476
57	MP0002064_seizures	1.07922707
58	MP0002210_abnormal_sex_determination	1.07545365
59	MP0005075_abnormal_melanosome_morpholog	1.05624661
60	MP0000230_abnormal_systemic_arterial	1.04763786
61	MP0002557_abnormal_social/conspecific_i	1.02945186
62	MP0002138_abnormal_hepatobiliary_system	1.02875543
63	MP0001188_hyperpigmentation	1.02336117
64	MP0001905_abnormal_dopamine_level	1.01799057
65	MP0002733_abnormal_thermal_nociception	1.01490049
66	MP0002928_abnormal_bile_duct	1.00970138
67	MP0000015_abnormal_ear_pigmentation	1.00746333
68	MP0008789_abnormal_olfactory_epithelium	1.00570578
69	MP0002735_abnormal_chemical_nociception	0.99439856
70	MP0008995_early_reproductive_senescence	0.98967968
71	MP0005386_behavior/neurological_phenoty	0.97682730
72	MP0004924_abnormal_behavior	0.97682730
73	MP0001970_abnormal_pain_threshold	0.97253839
74	MP0000383_abnormal_hair_follicle	0.96684916
75	MP0002751_abnormal_autonomic_nervous	0.96379784
76	MP0001529_abnormal_vocalization	0.95934610
77	MP0002063_abnormal_learning/memory/cond	0.94444938
78	MP0004742_abnormal_vestibular_system	0.93913324
79	MP0002067_abnormal_sensory_capabilities	0.91878300
80	MP0002095_abnormal_skin_pigmentation	0.89625771
81	MP0002734_abnormal_mechanical_nocicepti	0.88996902
82	MP0003718_maternal_effect	0.86739227
83	MP0002184_abnormal_innervation	0.85403169
84	MP0009764_decreased_sensitivity_to	0.84748389
85	MP0002752_abnormal_somatic_nervous	0.82472307
86	MP0000653_abnormal_sex_gland	0.82368446
87	MP0002234_abnormal_pharynx_morphology	0.81580922
88	MP0001764_abnormal_homeostasis	0.81370152
89	MP0001145_abnormal_male_reproductive	0.80937284
90	MP0005332_abnormal_amino_acid	0.80907133
91	MP0000647_abnormal_sebaceous_gland	0.78015669
92	MP0003119_abnormal_digestive_system	0.77543194
93	MP0000566_synostosis	0.76230642
94	MP0003890_abnormal_embryonic-extraembry	0.75979907
95	MP0002229_neurodegeneration	0.75910776
96	MP0003121_genomic_imprinting	0.75589352
97	MP0010386_abnormal_urinary_bladder	0.74978707
98	MP0005167_abnormal_blood-brain_barrier	0.73886902
99	MP0009780_abnormal_chondrocyte_physiolo	0.73290223
100	MP0000049_abnormal_middle_ear	0.73139786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.26957672
2	Abnormality of midbrain morphology (HP:0002418)	4.25151791
3	Molar tooth sign on MRI (HP:0002419)	4.25151791
4	Type II lissencephaly (HP:0007260)	4.17136962
5	Congenital stationary night blindness (HP:0007642)	3.98473140
6	Pancreatic fibrosis (HP:0100732)	3.86420766
7	Nephronophthisis (HP:0000090)	3.78319430
8	True hermaphroditism (HP:0010459)	3.69344391
9	Abolished electroretinogram (ERG) (HP:0000550)	3.30128104
10	Cerebellar dysplasia (HP:0007033)	3.28933910
11	Inability to walk (HP:0002540)	3.18885605
12	Abnormality of the renal medulla (HP:0100957)	3.12557831
13	Hypoplasia of the pons (HP:0012110)	3.02808631
14	Abnormality of the pons (HP:0007361)	2.94654059
15	Abnormality of the renal cortex (HP:0011035)	2.93439127
16	Medial flaring of the eyebrow (HP:0010747)	2.90697793
17	Progressive inability to walk (HP:0002505)	2.83064520
18	Chronic hepatic failure (HP:0100626)	2.77801153
19	Retinal dysplasia (HP:0007973)	2.75366236
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.71918848
21	Hyperventilation (HP:0002883)	2.64885358
22	Attenuation of retinal blood vessels (HP:0007843)	2.60373649
23	Oligodactyly (hands) (HP:0001180)	2.56757609
24	Cystic liver disease (HP:0006706)	2.52166833
25	Febrile seizures (HP:0002373)	2.49643554
26	Bile duct proliferation (HP:0001408)	2.40116631
27	Abnormal biliary tract physiology (HP:0012439)	2.40116631
28	Lissencephaly (HP:0001339)	2.32169332
29	Renal cortical cysts (HP:0000803)	2.30003235
30	Polydipsia (HP:0001959)	2.29508676
31	Abnormal drinking behavior (HP:0030082)	2.29508676
32	Sclerocornea (HP:0000647)	2.28173773
33	Abnormality of DNA repair (HP:0003254)	2.28032582
34	Retinal atrophy (HP:0001105)	2.27242576
35	Gaze-evoked nystagmus (HP:0000640)	2.26454555
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24477696
37	Absent/shortened dynein arms (HP:0200106)	2.24477696
38	Acute necrotizing encephalopathy (HP:0006965)	2.23571083
39	Gait imbalance (HP:0002141)	2.20628240
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.20340301
41	Pachygyria (HP:0001302)	2.17680526
42	Concave nail (HP:0001598)	2.16969208
43	Postaxial foot polydactyly (HP:0001830)	2.14961609
44	Tubular atrophy (HP:0000092)	2.13706618
45	Esophageal atresia (HP:0002032)	2.13289241
46	Anencephaly (HP:0002323)	2.13171218
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12592843
48	Abnormality of alanine metabolism (HP:0010916)	2.12592843
49	Hyperalaninemia (HP:0003348)	2.12592843
50	Congenital, generalized hypertrichosis (HP:0004540)	2.12407931
51	Increased CSF lactate (HP:0002490)	2.11792159
52	Congenital hepatic fibrosis (HP:0002612)	2.10961032
53	Congenital primary aphakia (HP:0007707)	2.10249397
54	Optic disc pallor (HP:0000543)	2.09257260
55	Progressive macrocephaly (HP:0004481)	2.08222893
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.07478044
57	Optic nerve hypoplasia (HP:0000609)	2.07424809
58	Mitochondrial inheritance (HP:0001427)	2.05660160
59	Male pseudohermaphroditism (HP:0000037)	2.04582000
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04349063
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.02342800
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02342800
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01995614
64	Atonic seizures (HP:0010819)	2.01377591
65	Severe muscular hypotonia (HP:0006829)	2.01127915
66	Acute encephalopathy (HP:0006846)	2.00688263
67	3-Methylglutaconic aciduria (HP:0003535)	1.98410733
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97916493
69	Pendular nystagmus (HP:0012043)	1.96235207
70	Furrowed tongue (HP:0000221)	1.95426917
71	Abnormality of the renal collecting system (HP:0004742)	1.92035029
72	Nephrogenic diabetes insipidus (HP:0009806)	1.91173241
73	Polyuria (HP:0000103)	1.88840451
74	Hepatocellular necrosis (HP:0001404)	1.86808269
75	Decreased central vision (HP:0007663)	1.85617742
76	Abnormal ciliary motility (HP:0012262)	1.82217340
77	Focal motor seizures (HP:0011153)	1.80110793
78	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.79779454
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79429405
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78678658
81	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78295126
82	Clumsiness (HP:0002312)	1.77107977
83	Broad-based gait (HP:0002136)	1.76974849
84	Hypothermia (HP:0002045)	1.76568414
85	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.76444425
86	Tachypnea (HP:0002789)	1.75861196
87	Increased corneal curvature (HP:0100692)	1.74002458
88	Keratoconus (HP:0000563)	1.74002458
89	Hemiparesis (HP:0001269)	1.72506436
90	Preaxial hand polydactyly (HP:0001177)	1.71723760
91	Gastrointestinal atresia (HP:0002589)	1.70719175
92	Genital tract atresia (HP:0001827)	1.70580893
93	Protruding tongue (HP:0010808)	1.70578571
94	Hepatic necrosis (HP:0002605)	1.70154317
95	Absent thumb (HP:0009777)	1.69576961
96	Meckel diverticulum (HP:0002245)	1.69484062
97	Abnormality of the ileum (HP:0001549)	1.68950309
98	Postaxial hand polydactyly (HP:0001162)	1.68746279
99	Hypoplasia of the fovea (HP:0007750)	1.68542811
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.68542811

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.55700691
2	TLK1	3.70432334
3	MAP4K2	3.31673051
4	ADRBK2	2.97772008
5	PINK1	2.96767509
6	ZAK	2.72396928
7	GRK1	2.59105196
8	WNK3	2.31135886
9	TAOK3	2.27402302
10	BMPR1B	2.14576497
11	TAOK2	2.11537775
12	NUAK1	2.02111953
13	TXK	2.01595361
14	TIE1	1.93476795
15	MAPK13	1.92800745
16	WNK4	1.84492344
17	OXSR1	1.81284524
18	MAP3K4	1.74047331
19	MAPKAPK3	1.72628131
20	MAP2K6	1.68825570
21	MARK3	1.64650291
22	ACVR1B	1.47247446
23	STK39	1.44188811
24	NEK2	1.41900391
25	CDK19	1.30736785
26	INSRR	1.30662384
27	MST4	1.28608620
28	PTK2B	1.24286029
29	NME1	1.16348051
30	SIK2	1.15347901
31	PLK4	1.13775161
32	ADRBK1	1.13731352
33	CASK	1.11586309
34	NEK1	1.03599338
35	PLK2	1.01865379
36	MUSK	1.00839338
37	TNIK	1.00555720
38	TEC	0.94761713
39	STK38L	0.94716287
40	DYRK2	0.93774067
41	CSNK1G2	0.90634955
42	BCKDK	0.90627781
43	PRKCG	0.84334917
44	MAPKAPK5	0.83502450
45	MAP2K7	0.81802822
46	MAP3K5	0.81453116
47	PRKCQ	0.81297312
48	PRKCE	0.80409063
49	CSNK1G3	0.79988033
50	CAMKK2	0.78627433
51	STK3	0.77483970
52	MARK1	0.72846202
53	DAPK2	0.72735247
54	CSNK1G1	0.71814060
55	PNCK	0.68076490
56	PAK3	0.67976244
57	KIT	0.67335333
58	PIK3CA	0.66449888
59	EIF2AK3	0.66173422
60	NTRK2	0.63619804
61	STK11	0.62347783
62	IKBKB	0.59322162
63	FGFR2	0.58773280
64	CSNK1A1L	0.57599081
65	PHKG2	0.56436464
66	PHKG1	0.56436464
67	RPS6KA5	0.55827210
68	FLT3	0.55427900
69	TNK2	0.47271526
70	CAMK2A	0.46630285
71	CSNK1A1	0.46105638
72	NTRK3	0.43945421
73	TGFBR1	0.43781612
74	PKN1	0.43289079
75	VRK1	0.40464239
76	TRIM28	0.38920561
77	IGF1R	0.38860834
78	DYRK3	0.38807243
79	BRSK2	0.38629950
80	GRK5	0.38390942
81	STK10	0.38113909
82	IRAK1	0.37181903
83	TRPM7	0.36700354
84	PRKACA	0.35831342
85	PRKCA	0.34767756
86	FER	0.34501617
87	CCNB1	0.34476087
88	MAP2K2	0.32384700
89	OBSCN	0.32059946
90	SYK	0.32053639
91	CSNK1D	0.31488610
92	DYRK1A	0.31115489
93	CSF1R	0.30290414
94	PRKG1	0.30012413
95	PLK3	0.29726174
96	ITK	0.28961356
97	CDK3	0.27881811
98	ATR	0.27410443
99	CAMK1	0.27307347
100	PLK1	0.26465983

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.07636854
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.87549021
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.86930767
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.67957293
5	Butanoate metabolism_Homo sapiens_hsa00650	2.13920107
6	Nicotine addiction_Homo sapiens_hsa05033	2.13465752
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.10308937
8	Homologous recombination_Homo sapiens_hsa03440	2.07875656
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.97781821
10	Asthma_Homo sapiens_hsa05310	1.93098832
11	Regulation of autophagy_Homo sapiens_hsa04140	1.85773818
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84343650
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83183305
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.82144832
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82106475
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81533481
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80462587
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.78440169
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78317666
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.78120559
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76037047
22	Basal transcription factors_Homo sapiens_hsa03022	1.73214086
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58504189
24	Parkinsons disease_Homo sapiens_hsa05012	1.49837701
25	Olfactory transduction_Homo sapiens_hsa04740	1.49832836
26	Allograft rejection_Homo sapiens_hsa05330	1.48631096
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.42931871
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.41553897
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32461588
30	Taste transduction_Homo sapiens_hsa04742	1.31284292
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.29806458
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.24627921
33	Propanoate metabolism_Homo sapiens_hsa00640	1.22990544
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22035193
35	Morphine addiction_Homo sapiens_hsa05032	1.21297080
36	RNA polymerase_Homo sapiens_hsa03020	1.16963304
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13215032
38	Caffeine metabolism_Homo sapiens_hsa00232	1.11432339
39	One carbon pool by folate_Homo sapiens_hsa00670	1.07895710
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05216647
41	Peroxisome_Homo sapiens_hsa04146	1.05129570
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04121026
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98885675
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98380133
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97001281
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96859271
47	Circadian entrainment_Homo sapiens_hsa04713	0.95013086
48	RNA degradation_Homo sapiens_hsa03018	0.94902239
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.92544588
50	Protein export_Homo sapiens_hsa03060	0.91906207
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91301782
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91178785
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90547070
54	Retinol metabolism_Homo sapiens_hsa00830	0.89372193
55	Huntingtons disease_Homo sapiens_hsa05016	0.88985007
56	GABAergic synapse_Homo sapiens_hsa04727	0.87832453
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87815340
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86656009
59	Salivary secretion_Homo sapiens_hsa04970	0.84594526
60	Serotonergic synapse_Homo sapiens_hsa04726	0.82667473
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80977247
62	Purine metabolism_Homo sapiens_hsa00230	0.80932394
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.79691743
64	Alzheimers disease_Homo sapiens_hsa05010	0.78446420
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.74772902
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73582794
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71590216
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70366656
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68498200
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67654306
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65960548
72	Insulin secretion_Homo sapiens_hsa04911	0.65731863
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65167089
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65085892
75	ABC transporters_Homo sapiens_hsa02010	0.64306842
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64141828
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.62287390
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62177435
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61566165
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60432354
81	Ribosome_Homo sapiens_hsa03010	0.59319559
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57602462
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.53546881
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.52922226
85	Antigen processing and presentation_Homo sapiens_hsa04612	0.52827007
86	Long-term depression_Homo sapiens_hsa04730	0.52539705
87	Fatty acid elongation_Homo sapiens_hsa00062	0.50145056
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47396805
89	Metabolic pathways_Homo sapiens_hsa01100	0.46565246
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46429703
91	Cocaine addiction_Homo sapiens_hsa05030	0.44928942
92	Fatty acid degradation_Homo sapiens_hsa00071	0.44509872
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.43943701
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.41638313
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40857935
96	Gastric acid secretion_Homo sapiens_hsa04971	0.40085657
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39734865
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38893704
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37940165
100	Sulfur metabolism_Homo sapiens_hsa00920	0.37462981

TPTE2P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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