ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of gene silencing by RNA (GO:0060966)	4.97958356
2	regulation of posttranscriptional gene silencing (GO:0060147)	4.97958356
3	regulation of gene silencing by miRNA (GO:0060964)	4.97958356
4	DNA replication checkpoint (GO:0000076)	4.79502887
5	synapsis (GO:0007129)	4.18824102
6	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.85294398
7	DNA double-strand break processing (GO:0000729)	3.83243949
8	meiotic chromosome segregation (GO:0045132)	3.82644577
9	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.78021898
10	replication fork processing (GO:0031297)	3.73825734
11	DNA methylation involved in gamete generation (GO:0043046)	3.71339472
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.69178135
13	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.66224752
14	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.66224752
15	regulation of meiosis I (GO:0060631)	3.58647133
16	nucleobase biosynthetic process (GO:0046112)	3.52834574
17	recombinational repair (GO:0000725)	3.49515528
18	double-strand break repair via homologous recombination (GO:0000724)	3.48837631
19	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.45370998
20	regulation of translation, ncRNA-mediated (GO:0045974)	3.45370998
21	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.45370998
22	nuclear pore complex assembly (GO:0051292)	3.42817823
23	regulation of histone H3-K9 methylation (GO:0051570)	3.38269023
24	microtubule polymerization or depolymerization (GO:0031109)	3.35765471
25	monoubiquitinated protein deubiquitination (GO:0035520)	3.34138687
26	intra-S DNA damage checkpoint (GO:0031573)	3.33764112
27	nuclear pore organization (GO:0006999)	3.31085801
28	DNA replication initiation (GO:0006270)	3.30939249
29	resolution of meiotic recombination intermediates (GO:0000712)	3.28360157
30	regulation of centriole replication (GO:0046599)	3.27276963
31	regulation of histone H3-K4 methylation (GO:0051569)	3.25996569
32	reflex (GO:0060004)	3.23636140
33	microtubule depolymerization (GO:0007019)	3.17931547
34	reciprocal DNA recombination (GO:0035825)	3.14417693
35	reciprocal meiotic recombination (GO:0007131)	3.14417693
36	IMP biosynthetic process (GO:0006188)	3.14223836
37	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.11388860
38	male meiosis (GO:0007140)	3.11290983
39	purine nucleobase biosynthetic process (GO:0009113)	3.07801629
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.96100435
41	regulation of mitotic spindle checkpoint (GO:1903504)	2.96100435
42	chromatin remodeling at centromere (GO:0031055)	2.94222565
43	centriole replication (GO:0007099)	2.91350941
44	positive regulation of histone H3-K4 methylation (GO:0051571)	2.91339839
45	indolalkylamine metabolic process (GO:0006586)	2.90686532
46	tryptophan catabolic process (GO:0006569)	2.90001102
47	indole-containing compound catabolic process (GO:0042436)	2.90001102
48	indolalkylamine catabolic process (GO:0046218)	2.90001102
49	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.89135473
50	protein K48-linked deubiquitination (GO:0071108)	2.85634902
51	auditory receptor cell stereocilium organization (GO:0060088)	2.85469409
52	regulation of hippo signaling (GO:0035330)	2.85410946
53	histone exchange (GO:0043486)	2.85350979
54	regulation of gene expression by genetic imprinting (GO:0006349)	2.85248287
55	photoreceptor cell maintenance (GO:0045494)	2.82888095
56	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.78412207
57	CENP-A containing nucleosome assembly (GO:0034080)	2.77417110
58	mitochondrial RNA metabolic process (GO:0000959)	2.74898168
59	amine catabolic process (GO:0009310)	2.74738763
60	cellular biogenic amine catabolic process (GO:0042402)	2.74738763
61	negative regulation of histone methylation (GO:0031061)	2.73510416
62	gene silencing by RNA (GO:0031047)	2.71596191
63	pre-miRNA processing (GO:0031054)	2.71495980
64	methionine biosynthetic process (GO:0009086)	2.71466526
65	DNA strand elongation involved in DNA replication (GO:0006271)	2.70412415
66	folic acid-containing compound biosynthetic process (GO:0009396)	2.69728195
67	regulation of centrosome cycle (GO:0046605)	2.69408232
68	sulfation (GO:0051923)	2.69237532
69	regulation of gene silencing (GO:0060968)	2.69151560
70	IMP metabolic process (GO:0046040)	2.68433430
71	pore complex assembly (GO:0046931)	2.67860339
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.67822853
73	telomere maintenance via telomerase (GO:0007004)	2.66365780
74	mismatch repair (GO:0006298)	2.65967659
75	kynurenine metabolic process (GO:0070189)	2.65520637
76	tryptophan metabolic process (GO:0006568)	2.62632457
77	cilium or flagellum-dependent cell motility (GO:0001539)	2.61917090
78	mitotic G2/M transition checkpoint (GO:0044818)	2.61450386
79	centrosome organization (GO:0051297)	2.59968105
80	DNA catabolic process, exonucleolytic (GO:0000738)	2.58962301
81	response to misfolded protein (GO:0051788)	2.58287487
82	sulfur amino acid biosynthetic process (GO:0000097)	2.57293005
83	double-strand break repair (GO:0006302)	2.54590971
84	DNA methylation (GO:0006306)	2.53697414
85	DNA alkylation (GO:0006305)	2.53697414
86	righting reflex (GO:0060013)	2.53444583
87	sensory perception of smell (GO:0007608)	2.52890943
88	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.52278121
89	negative regulation of sister chromatid segregation (GO:0033046)	2.52278121
90	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.52278121
91	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.52278121
92	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.52278121
93	DNA strand elongation (GO:0022616)	2.51698956
94	fucose catabolic process (GO:0019317)	2.51626667
95	L-fucose metabolic process (GO:0042354)	2.51626667
96	L-fucose catabolic process (GO:0042355)	2.51626667
97	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.51236861
98	negative regulation of chromosome segregation (GO:0051985)	2.50301449
99	protein K11-linked deubiquitination (GO:0035871)	2.49885853
100	protein K63-linked deubiquitination (GO:0070536)	2.49668995

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.24590559
2	VDR_22108803_ChIP-Seq_LS180_Human	4.10751146
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.98770891
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.49989519
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24285037
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.20524762
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.95588660
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77944182
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66862160
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.55355671
11	EWS_26573619_Chip-Seq_HEK293_Human	2.42887126
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17730971
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99165742
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98571702
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95815877
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.91859771
17	FUS_26573619_Chip-Seq_HEK293_Human	1.78958310
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76800018
19	P300_19829295_ChIP-Seq_ESCs_Human	1.75803836
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.75004821
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72676663
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63331303
23	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62557849
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58507928
25	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.56348254
26	SCL_19346495_ChIP-Seq_HPC-7_Human	1.55008954
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.53802427
28	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.51317589
29	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.51317589
30	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.51317589
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51231607
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.50808468
33	STAT3_23295773_ChIP-Seq_U87_Human	1.48688418
34	TCF4_23295773_ChIP-Seq_U87_Human	1.48504277
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48265587
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48265587
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48043140
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46889325
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44240006
40	GATA1_22025678_ChIP-Seq_K562_Human	1.39117002
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38799949
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.36994727
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.35897881
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.34594717
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34188528
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33608113
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31346697
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30149100
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25789960
50	ETV1_20927104_ChIP-Seq_GIST48_Human	1.23206157
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22800064
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20385802
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20385802
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19190807
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17143584
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.17143584
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16422019
58	GATA1_19941826_ChIP-Seq_K562_Human	1.15565855
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15211271
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14316730
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13760300
62	PHF8_20622853_ChIP-Seq_HELA_Human	1.13040385
63	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.12490672
64	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.11938957
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.11573300
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10742345
67	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10214383
68	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09928057
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09500578
70	NFYB_21822215_ChIP-Seq_K562_Human	1.08692949
71	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07007648
72	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.06359142
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.05394916
74	NFYA_21822215_ChIP-Seq_K562_Human	1.05130879
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05017374
76	VDR_23849224_ChIP-Seq_CD4+_Human	1.04964718
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03909041
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03909041
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03849873
80	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.03735323
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02797624
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01644576
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00665091
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00382120
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00227285
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98756749
87	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98087023
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98038330
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97153717
90	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95882494
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95715154
92	TBL1_22424771_ChIP-Seq_293T_Human	0.95547040
93	GATA2_19941826_ChIP-Seq_K562_Human	0.95208252
94	JUN_21703547_ChIP-Seq_K562_Human	0.94888243
95	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.93996605
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93639965
97	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.93504423
98	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91238549
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90784392
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90342358

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.24197072
2	MP0008877_abnormal_DNA_methylation	3.57713479
3	MP0004147_increased_porphyrin_level	3.17131353
4	MP0010094_abnormal_chromosome_stability	3.11134805
5	MP0008058_abnormal_DNA_repair	3.00110347
6	MP0003718_maternal_effect	2.89900704
7	MP0002736_abnormal_nociception_after	2.71795769
8	MP0003646_muscle_fatigue	2.45854391
9	MP0008995_early_reproductive_senescence	2.41989709
10	MP0004957_abnormal_blastocyst_morpholog	2.33853847
11	MP0003111_abnormal_nucleus_morphology	2.32017818
12	MP0003693_abnormal_embryo_hatching	2.31401654
13	MP0003890_abnormal_embryonic-extraembry	2.29494584
14	MP0009697_abnormal_copulation	2.26042804
15	MP0003136_yellow_coat_color	2.22357472
16	MP0001968_abnormal_touch/_nociception	2.14849400
17	MP0003195_calcinosis	1.98197209
18	MP0003941_abnormal_skin_development	1.89996816
19	MP0004145_abnormal_muscle_electrophysio	1.87783952
20	MP0008872_abnormal_physiological_respon	1.86826363
21	MP0009046_muscle_twitch	1.83749358
22	MP0008932_abnormal_embryonic_tissue	1.82111614
23	MP0008007_abnormal_cellular_replicative	1.81577071
24	MP0002254_reproductive_system_inflammat	1.70805718
25	MP0005646_abnormal_pituitary_gland	1.63339034
26	MP0003077_abnormal_cell_cycle	1.58407694
27	MP0000678_abnormal_parathyroid_gland	1.58190766
28	MP0004084_abnormal_cardiac_muscle	1.53151140
29	MP0005410_abnormal_fertilization	1.52895690
30	MP0005083_abnormal_biliary_tract	1.45152991
31	MP0008775_abnormal_heart_ventricle	1.44762436
32	MP0001929_abnormal_gametogenesis	1.42994590
33	MP0003119_abnormal_digestive_system	1.41519522
34	MP0006292_abnormal_olfactory_placode	1.40919037
35	MP0003806_abnormal_nucleotide_metabolis	1.37567523
36	MP0005551_abnormal_eye_electrophysiolog	1.37129925
37	MP0005451_abnormal_body_composition	1.34627131
38	MP0003786_premature_aging	1.33545062
39	MP0002210_abnormal_sex_determination	1.32696097
40	MP0003698_abnormal_male_reproductive	1.30603041
41	MP0000569_abnormal_digit_pigmentation	1.29420711
42	MP0004215_abnormal_myocardial_fiber	1.27595089
43	MP0003787_abnormal_imprinting	1.26266814
44	MP0002102_abnormal_ear_morphology	1.24727182
45	MP0006035_abnormal_mitochondrial_morpho	1.24397375
46	MP0005464_abnormal_platelet_physiology	1.19515054
47	MP0001486_abnormal_startle_reflex	1.18299694
48	MP0006276_abnormal_autonomic_nervous	1.17098609
49	MP0006036_abnormal_mitochondrial_physio	1.14184107
50	MP0004043_abnormal_pH_regulation	1.13377509
51	MP0002733_abnormal_thermal_nociception	1.12414581
52	MP0005395_other_phenotype	1.08070159
53	MP0003937_abnormal_limbs/digits/tail_de	1.07872963
54	MP0005253_abnormal_eye_physiology	1.07634160
55	MP0001145_abnormal_male_reproductive	1.06916657
56	MP0004133_heterotaxia	1.06117475
57	MP0002735_abnormal_chemical_nociception	1.05594797
58	MP0006072_abnormal_retinal_apoptosis	1.02558176
59	MP0000653_abnormal_sex_gland	1.02526906
60	MP0001485_abnormal_pinna_reflex	1.01902815
61	MP0003567_abnormal_fetal_cardiomyocyte	1.01761215
62	MP0005397_hematopoietic_system_phenotyp	0.98786403
63	MP0001545_abnormal_hematopoietic_system	0.98786403
64	MP0004036_abnormal_muscle_relaxation	0.96845232
65	MP0005174_abnormal_tail_pigmentation	0.94666017
66	MP0008770_decreased_survivor_rate	0.94011463
67	MP0000230_abnormal_systemic_arterial	0.92553408
68	MP0002837_dystrophic_cardiac_calcinosis	0.88900506
69	MP0000631_abnormal_neuroendocrine_gland	0.87481906
70	MP0003656_abnormal_erythrocyte_physiolo	0.87455432
71	MP0002084_abnormal_developmental_patter	0.86275152
72	MP0001529_abnormal_vocalization	0.86132630
73	MP0000372_irregular_coat_pigmentation	0.85744049
74	MP0001697_abnormal_embryo_size	0.85537159
75	MP0003186_abnormal_redox_activity	0.83298766
76	MP0010307_abnormal_tumor_latency	0.81363145
77	MP0005266_abnormal_metabolism	0.81130937
78	MP0005380_embryogenesis_phenotype	0.80336927
79	MP0001672_abnormal_embryogenesis/_devel	0.80336927
80	MP0002132_abnormal_respiratory_system	0.79917774
81	MP0003950_abnormal_plasma_membrane	0.78982570
82	MP0001970_abnormal_pain_threshold	0.78722499
83	MP0009745_abnormal_behavioral_response	0.78535506
84	MP0002067_abnormal_sensory_capabilities	0.77794753
85	MP0005647_abnormal_sex_gland	0.76517740
86	MP0001661_extended_life_span	0.76217825
87	MP0001501_abnormal_sleep_pattern	0.75091217
88	MP0005171_absent_coat_pigmentation	0.74598851
89	MP0005645_abnormal_hypothalamus_physiol	0.74567923
90	MP0009703_decreased_birth_body	0.74099860
91	MP0001730_embryonic_growth_arrest	0.73433238
92	MP0005167_abnormal_blood-brain_barrier	0.73134693
93	MP0003137_abnormal_impulse_conducting	0.72566594
94	MP0009672_abnormal_birth_weight	0.72075740
95	MP0004197_abnormal_fetal_growth/weight/	0.71650440
96	MP0000647_abnormal_sebaceous_gland	0.70469497
97	MP0002088_abnormal_embryonic_growth/wei	0.69497019
98	MP0003984_embryonic_growth_retardation	0.69443956
99	MP0002161_abnormal_fertility/fecundity	0.66855586
100	MP0004130_abnormal_muscle_cell	0.66669100

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	4.60820735
2	Abnormality of the labia minora (HP:0012880)	3.63021308
3	Clumsiness (HP:0002312)	3.42603141
4	Chromsome breakage (HP:0040012)	3.29118218
5	Pancreatic cysts (HP:0001737)	3.26890528
6	Protruding tongue (HP:0010808)	3.18915919
7	Pancreatic fibrosis (HP:0100732)	3.13649655
8	Truncus arteriosus (HP:0001660)	3.07349415
9	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.06817825
10	Genetic anticipation (HP:0003743)	2.87230141
11	Gaze-evoked nystagmus (HP:0000640)	2.78582601
12	True hermaphroditism (HP:0010459)	2.74195217
13	Abnormality of homocysteine metabolism (HP:0010919)	2.73644612
14	Homocystinuria (HP:0002156)	2.73644612
15	Abnormality of alanine metabolism (HP:0010916)	2.59480008
16	Hyperalaninemia (HP:0003348)	2.59480008
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59480008
18	Poikilocytosis (HP:0004447)	2.52556907
19	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.52286011
20	Ileus (HP:0002595)	2.49336741
21	Hyperventilation (HP:0002883)	2.42143912
22	Abnormality of midbrain morphology (HP:0002418)	2.40418389
23	Molar tooth sign on MRI (HP:0002419)	2.40418389
24	Abolished electroretinogram (ERG) (HP:0000550)	2.39738455
25	Abnormality of chromosome stability (HP:0003220)	2.39496869
26	Central scotoma (HP:0000603)	2.38174479
27	Sloping forehead (HP:0000340)	2.29528435
28	Progressive cerebellar ataxia (HP:0002073)	2.28791721
29	Congenital stationary night blindness (HP:0007642)	2.28479870
30	Acanthocytosis (HP:0001927)	2.24998012
31	Duplicated collecting system (HP:0000081)	2.24577906
32	Attenuation of retinal blood vessels (HP:0007843)	2.23244121
33	Meckel diverticulum (HP:0002245)	2.22726108
34	Hypoplasia of the pons (HP:0012110)	2.22660399
35	Colon cancer (HP:0003003)	2.22081785
36	Abnormality of cochlea (HP:0000375)	2.21736384
37	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.18025121
38	Abnormality of the pons (HP:0007361)	2.17094292
39	Abnormality of the ileum (HP:0001549)	2.16893140
40	Abnormality of the renal collecting system (HP:0004742)	2.16295709
41	Hypoplastic labia majora (HP:0000059)	2.15951706
42	Absent/shortened dynein arms (HP:0200106)	2.14682514
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.14682514
44	Small hand (HP:0200055)	2.13652426
45	Inability to walk (HP:0002540)	2.12305740
46	Broad-based gait (HP:0002136)	2.06828319
47	Prolonged bleeding time (HP:0003010)	2.05593971
48	Bowel incontinence (HP:0002607)	2.05282592
49	Small intestinal stenosis (HP:0012848)	2.05183518
50	Duodenal stenosis (HP:0100867)	2.05183518
51	Abnormality of the preputium (HP:0100587)	2.03724969
52	Hyperthyroidism (HP:0000836)	2.03545582
53	Acute myeloid leukemia (HP:0004808)	2.01154741
54	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.99108266
55	Abnormal large intestine physiology (HP:0012700)	1.99017767
56	Dysmetric saccades (HP:0000641)	1.98708378
57	Nephronophthisis (HP:0000090)	1.97074867
58	Abnormality of the labia majora (HP:0012881)	1.95921910
59	Ectopic kidney (HP:0000086)	1.95773621
60	Cystic liver disease (HP:0006706)	1.94947033
61	Patellar aplasia (HP:0006443)	1.93553189
62	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.93315835
63	Cholecystitis (HP:0001082)	1.92121877
64	Abnormal gallbladder physiology (HP:0012438)	1.92121877
65	Abnormal lung lobation (HP:0002101)	1.91312328
66	Congenital sensorineural hearing impairment (HP:0008527)	1.90092810
67	Sclerocornea (HP:0000647)	1.89370192
68	Anencephaly (HP:0002323)	1.88654824
69	Acute lymphatic leukemia (HP:0006721)	1.88460614
70	Absent radius (HP:0003974)	1.84016143
71	Fair hair (HP:0002286)	1.83665075
72	Morphological abnormality of the inner ear (HP:0011390)	1.81733638
73	Ependymoma (HP:0002888)	1.81681699
74	Furrowed tongue (HP:0000221)	1.80967850
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79773484
76	Cupped ear (HP:0000378)	1.79148628
77	Abnormality of the duodenum (HP:0002246)	1.78047843
78	Pancreatic islet-cell hyperplasia (HP:0004510)	1.76599277
79	Pendular nystagmus (HP:0012043)	1.75750460
80	Neoplasm of the small intestine (HP:0100833)	1.73445466
81	Scotoma (HP:0000575)	1.72689252
82	Absent forearm bone (HP:0003953)	1.71497181
83	Aplasia involving forearm bones (HP:0009822)	1.71497181
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71424348
85	Nephroblastoma (Wilms tumor) (HP:0002667)	1.71364756
86	Abnormality of the renal medulla (HP:0100957)	1.71241641
87	Myelodysplasia (HP:0002863)	1.70235538
88	Biliary tract neoplasm (HP:0100574)	1.70132629
89	Areflexia of lower limbs (HP:0002522)	1.69141360
90	Clubbing of toes (HP:0100760)	1.68566519
91	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.68553153
92	Labial hypoplasia (HP:0000066)	1.67402967
93	Progressive inability to walk (HP:0002505)	1.67054786
94	Type II lissencephaly (HP:0007260)	1.66945507
95	Tinnitus (HP:0000360)	1.66556786
96	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.66541083
97	Male pseudohermaphroditism (HP:0000037)	1.65777541
98	Stomach cancer (HP:0012126)	1.64603534
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.64127971
100	Embryonal renal neoplasm (HP:0011794)	1.63224232

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.34310608
2	ACVR1B	2.71731632
3	BMPR1B	2.66572551
4	TNIK	2.65020224
5	ZAK	2.56495384
6	NUAK1	2.51862795
7	NTRK3	2.34860976
8	TTK	2.28957834
9	MKNK2	2.28952571
10	PLK4	2.26021960
11	CDC7	2.24630725
12	PINK1	2.08256530
13	MST4	2.02312304
14	PBK	2.00904348
15	ADRBK2	1.95917874
16	EIF2AK1	1.92583036
17	BRSK2	1.84150526
18	MKNK1	1.72216947
19	WNK3	1.60167999
20	STK3	1.52218062
21	RIPK4	1.52186362
22	GRK1	1.49510808
23	MAPK13	1.46933784
24	PLK3	1.42335093
25	NME1	1.38825983
26	BMX	1.37503586
27	RAF1	1.32052065
28	NEK2	1.30017501
29	TEC	1.28580654
30	WEE1	1.27330671
31	INSRR	1.19113603
32	MAP4K2	1.18896107
33	BUB1	1.18271581
34	EIF2AK3	1.16233568
35	MAP3K2	1.12379022
36	CLK1	1.07542784
37	CHEK2	1.07096420
38	KSR2	1.06786758
39	SRPK1	1.04265885
40	MARK3	1.02442862
41	NEK1	1.00370867
42	ATR	0.97219842
43	PTK2B	0.95516564
44	TSSK6	0.94322627
45	WNK4	0.93118142
46	PLK1	0.90724596
47	OXSR1	0.89557918
48	MAP3K4	0.88610373
49	TGFBR1	0.88314980
50	PIK3CG	0.87412782
51	TAOK3	0.85501297
52	NLK	0.83029357
53	PLK2	0.81572176
54	ATM	0.80295176
55	OBSCN	0.77864976
56	VRK1	0.75495155
57	STK38L	0.75163107
58	STK4	0.68683441
59	TLK1	0.67568636
60	WNK1	0.66383834
61	KSR1	0.65516477
62	LATS1	0.64803784
63	EEF2K	0.64374615
64	PKN1	0.64272417
65	TAF1	0.59647886
66	MAPKAPK5	0.58835663
67	PDK2	0.58218613
68	DYRK2	0.54849133
69	TNK2	0.54268638
70	BMPR2	0.53907619
71	PNCK	0.51061088
72	CDK1	0.50086494
73	CHEK1	0.49605721
74	MAP2K1	0.48363411
75	TIE1	0.48189618
76	BTK	0.47627380
77	ADRBK1	0.46360362
78	CSNK1G1	0.46358705
79	TRIM28	0.44845678
80	RPS6KB2	0.42666943
81	PAK1	0.39705059
82	CDK3	0.39159331
83	ALK	0.38547564
84	CSNK1E	0.38236393
85	VRK2	0.37699152
86	PRKCG	0.36421576
87	MAP3K8	0.35956337
88	CCNB1	0.33717288
89	CDK2	0.32977805
90	DYRK3	0.32790436
91	TRPM7	0.31814525
92	PAK3	0.30966228
93	CAMK1G	0.30830368
94	RPS6KA5	0.30388623
95	PRKDC	0.29460907
96	PIM1	0.29368974
97	MAP3K7	0.29005712
98	EIF2AK2	0.28962580
99	CSNK1A1L	0.28667974
100	PRKCB	0.28079430

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.09610284
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.33472952
3	One carbon pool by folate_Homo sapiens_hsa00670	3.18094421
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.06664346
5	Mismatch repair_Homo sapiens_hsa03430	3.02217536
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.83196302
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.47090501
8	DNA replication_Homo sapiens_hsa03030	2.38850260
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.32983711
10	RNA polymerase_Homo sapiens_hsa03020	2.32211687
11	Basal transcription factors_Homo sapiens_hsa03022	2.24984263
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.21614206
13	Olfactory transduction_Homo sapiens_hsa04740	2.13423630
14	Phototransduction_Homo sapiens_hsa04744	2.13077282
15	Butanoate metabolism_Homo sapiens_hsa00650	2.00245377
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.93249840
17	RNA transport_Homo sapiens_hsa03013	1.86942649
18	Propanoate metabolism_Homo sapiens_hsa00640	1.82047001
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81733146
20	RNA degradation_Homo sapiens_hsa03018	1.76483141
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.75572921
22	Cell cycle_Homo sapiens_hsa04110	1.57791367
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56163823
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51869950
25	Purine metabolism_Homo sapiens_hsa00230	1.48609694
26	Nicotine addiction_Homo sapiens_hsa05033	1.44510719
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44463897
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39060144
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.33942143
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30084220
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.23721860
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.23110552
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.21253381
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.20146823
35	Taste transduction_Homo sapiens_hsa04742	1.18778861
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15208179
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13088446
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11422992
39	Spliceosome_Homo sapiens_hsa03040	1.10934228
40	mRNA surveillance pathway_Homo sapiens_hsa03015	1.06732962
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.06168989
42	ABC transporters_Homo sapiens_hsa02010	1.03362362
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.00976777
44	Base excision repair_Homo sapiens_hsa03410	1.00280876
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.89789975
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88151917
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87183451
48	Serotonergic synapse_Homo sapiens_hsa04726	0.85602071
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85369913
50	Oocyte meiosis_Homo sapiens_hsa04114	0.85117670
51	Lysine degradation_Homo sapiens_hsa00310	0.81335271
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80114154
53	Morphine addiction_Homo sapiens_hsa05032	0.78371307
54	Platelet activation_Homo sapiens_hsa04611	0.77840876
55	Retinol metabolism_Homo sapiens_hsa00830	0.77589910
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.77142328
57	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.76135242
58	Glutathione metabolism_Homo sapiens_hsa00480	0.72926386
59	Proteasome_Homo sapiens_hsa03050	0.67786488
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67238716
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66716543
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65865170
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62149546
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60041740
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59750518
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.59368241
67	Metabolic pathways_Homo sapiens_hsa01100	0.57672686
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57442477
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56177991
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.54813456
71	Circadian entrainment_Homo sapiens_hsa04713	0.54101660
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53828904
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52986968
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52655253
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52129102
76	GABAergic synapse_Homo sapiens_hsa04727	0.51616998
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50346730
78	Peroxisome_Homo sapiens_hsa04146	0.47128140
79	Long-term depression_Homo sapiens_hsa04730	0.44691290
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.44291817
81	Caffeine metabolism_Homo sapiens_hsa00232	0.43961543
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43680762
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43443983
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42918996
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42851307
86	Huntingtons disease_Homo sapiens_hsa05016	0.40457981
87	Regulation of autophagy_Homo sapiens_hsa04140	0.40030955
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37628485
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33668301
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33207937
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31734897
92	Parkinsons disease_Homo sapiens_hsa05012	0.31373098
93	Melanoma_Homo sapiens_hsa05218	0.29441388
94	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.29146759
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.28398012
96	Salivary secretion_Homo sapiens_hsa04970	0.26486896
97	p53 signaling pathway_Homo sapiens_hsa04115	0.22850268
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22295047
99	Insulin secretion_Homo sapiens_hsa04911	0.18493019
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.18456642

TPTEP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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