TRABD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.96731853
2L-phenylalanine catabolic process (GO:0006559)5.96731853
3COPI coating of Golgi vesicle (GO:0048205)5.86744862
4Golgi transport vesicle coating (GO:0048200)5.86744862
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.83542816
6L-phenylalanine metabolic process (GO:0006558)5.83542816
7positive regulation of gamma-delta T cell activation (GO:0046645)5.27918808
8intestinal cholesterol absorption (GO:0030299)5.16090699
9antigen processing and presentation of endogenous antigen (GO:0019883)5.10261672
10aromatic amino acid family catabolic process (GO:0009074)4.97118347
11negative regulation of cell killing (GO:0031342)4.88883006
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88883006
13negative regulation of erythrocyte differentiation (GO:0045647)4.81687277
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.81140424
15cysteine metabolic process (GO:0006534)4.73929228
16sulfur amino acid catabolic process (GO:0000098)4.64360333
17protein retention in ER lumen (GO:0006621)4.46129790
18valine metabolic process (GO:0006573)4.42313999
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.41269800
20glyoxylate metabolic process (GO:0046487)4.37330749
21kynurenine metabolic process (GO:0070189)4.32665908
22positive thymic T cell selection (GO:0045059)4.32659150
23COPII vesicle coating (GO:0048208)4.30524992
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.27838760
25alpha-linolenic acid metabolic process (GO:0036109)4.25832366
26exocrine pancreas development (GO:0031017)4.20212689
27indole-containing compound catabolic process (GO:0042436)4.18914417
28indolalkylamine catabolic process (GO:0046218)4.18914417
29tryptophan catabolic process (GO:0006569)4.18914417
30detection of bacterium (GO:0016045)4.17683091
31lysine catabolic process (GO:0006554)4.14024641
32lysine metabolic process (GO:0006553)4.14024641
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10662579
34positive regulation by organism of defense response of other organism involved in symbiotic interact4.10662579
35modulation by symbiont of host immune response (GO:0052553)4.10662579
36positive regulation by symbiont of host defense response (GO:0052509)4.10662579
37modulation by symbiont of host defense response (GO:0052031)4.10662579
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10662579
39tryptophan metabolic process (GO:0006568)4.09653223
404-hydroxyproline metabolic process (GO:0019471)4.09375913
41peptidyl-glutamic acid carboxylation (GO:0017187)4.09342516
42protein carboxylation (GO:0018214)4.09342516
43leukocyte aggregation (GO:0070486)4.09104290
44thymic T cell selection (GO:0045061)4.07541888
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05710529
46negative thymic T cell selection (GO:0045060)4.04812830
47detection of other organism (GO:0098543)4.01107306
48response to muramyl dipeptide (GO:0032495)3.99994802
49response to peptidoglycan (GO:0032494)3.99916931
50homocysteine metabolic process (GO:0050667)3.95463884
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.94835557
52bile acid biosynthetic process (GO:0006699)3.92508611
53regulation of gamma-delta T cell activation (GO:0046643)3.92154893
54urea metabolic process (GO:0019627)3.89833077
55urea cycle (GO:0000050)3.89833077
56high-density lipoprotein particle remodeling (GO:0034375)3.89144181
57cellular modified amino acid catabolic process (GO:0042219)3.86280619
58NIK/NF-kappaB signaling (GO:0038061)3.85080124
59complement activation, alternative pathway (GO:0006957)3.80439577
60negative T cell selection (GO:0043383)3.80197373
61activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.80120928
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79791343
63regulation of gamma-delta T cell differentiation (GO:0045586)3.78815771
64negative regulation of fibrinolysis (GO:0051918)3.78374117
65neutrophil activation involved in immune response (GO:0002283)3.76197213
66regulation of cholesterol homeostasis (GO:2000188)3.72835074
67immunoglobulin mediated immune response (GO:0016064)3.72494808
68positive regulation of B cell differentiation (GO:0045579)3.71514911
69T cell selection (GO:0045058)3.70964662
70aromatic amino acid family metabolic process (GO:0009072)3.67333987
71serine family amino acid catabolic process (GO:0009071)3.65966034
72regulation of B cell receptor signaling pathway (GO:0050855)3.65845295
73positive regulation of nuclease activity (GO:0032075)3.64347621
74nitrogen cycle metabolic process (GO:0071941)3.62217780
752-oxoglutarate metabolic process (GO:0006103)3.57690015
76regulation of triglyceride catabolic process (GO:0010896)3.57512502
77regulation of protein activation cascade (GO:2000257)3.56843589
78regulation of fibrinolysis (GO:0051917)3.55200496
79B cell receptor signaling pathway (GO:0050853)3.54263186
80bile acid metabolic process (GO:0008206)3.52404950
81alpha-amino acid catabolic process (GO:1901606)3.51463465
82reverse cholesterol transport (GO:0043691)3.47955080
83glycine metabolic process (GO:0006544)3.46155045
84intestinal absorption (GO:0050892)3.45029315
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43968512
86triglyceride homeostasis (GO:0070328)3.43053621
87acylglycerol homeostasis (GO:0055090)3.43053621
88amino-acid betaine metabolic process (GO:0006577)3.42902062
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.42434347
90negative regulation of sterol transport (GO:0032372)3.42324729
91negative regulation of cholesterol transport (GO:0032375)3.42324729
92tolerance induction (GO:0002507)3.40459537
93cellular amino acid catabolic process (GO:0009063)3.37982399
94tyrosine metabolic process (GO:0006570)3.37573411
95phospholipid efflux (GO:0033700)3.37229888
96positive T cell selection (GO:0043368)3.35511364
97macrophage activation involved in immune response (GO:0002281)3.35481557
98endoplasmic reticulum unfolded protein response (GO:0030968)3.33836210
99coenzyme catabolic process (GO:0009109)3.33708920
100regulation of complement activation (GO:0030449)3.33678437
101signal peptide processing (GO:0006465)3.32747407
102regulation of nuclease activity (GO:0032069)3.32376690
103fatty acid beta-oxidation (GO:0006635)3.31910589
104regulation of dendritic cell antigen processing and presentation (GO:0002604)3.31447340
105serine family amino acid metabolic process (GO:0009069)3.31357887
106bile acid and bile salt transport (GO:0015721)3.31055442
107germinal center formation (GO:0002467)3.29865872
108tricarboxylic acid metabolic process (GO:0072350)3.26886197
109regulation of B cell differentiation (GO:0045577)3.26168034
110mannose metabolic process (GO:0006013)3.26146281
111protein-lipid complex remodeling (GO:0034368)3.24767530
112macromolecular complex remodeling (GO:0034367)3.24767530
113plasma lipoprotein particle remodeling (GO:0034369)3.24767530
114fatty acid oxidation (GO:0019395)3.24439937
115cellular ketone body metabolic process (GO:0046950)3.23891312
116branched-chain amino acid metabolic process (GO:0009081)3.23621323
117cellular response to unfolded protein (GO:0034620)3.22287592
118aspartate family amino acid catabolic process (GO:0009068)3.21076658
119positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20327521
120short-chain fatty acid metabolic process (GO:0046459)3.19298084
121endocrine pancreas development (GO:0031018)3.18748884
122fatty acid catabolic process (GO:0009062)3.18610579
123ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.16658580
124serine family amino acid biosynthetic process (GO:0009070)3.16521858
125negative regulation of interleukin-12 production (GO:0032695)3.16194267
126lipid oxidation (GO:0034440)3.15839413
127oxaloacetate metabolic process (GO:0006107)3.15252625
128antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14083020
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14083020
130ER-nucleus signaling pathway (GO:0006984)3.13779392
131indolalkylamine metabolic process (GO:0006586)3.13475809
132regulation of cholesterol esterification (GO:0010872)3.12055487
133branched-chain amino acid catabolic process (GO:0009083)3.10376049
134organic acid catabolic process (GO:0016054)3.09747941
135carboxylic acid catabolic process (GO:0046395)3.09747941
136ethanol oxidation (GO:0006069)3.09446438
137regulation of mast cell degranulation (GO:0043304)3.09399832
138positive regulation of lipoprotein lipase activity (GO:0051006)3.08678273
139positive regulation of triglyceride lipase activity (GO:0061365)3.08678273
140monocarboxylic acid catabolic process (GO:0072329)3.07243867
141cellular response to topologically incorrect protein (GO:0035967)3.05965854
142Peyers patch development (GO:0048541)3.05578601
143mucosal-associated lymphoid tissue development (GO:0048537)3.05578601
1443-UTR-mediated mRNA stabilization (GO:0070935)3.05206029
145detection of external biotic stimulus (GO:0098581)3.05036842
146plasma lipoprotein particle clearance (GO:0034381)3.04640473
147transcytosis (GO:0045056)3.04075508
148negative regulation of lymphocyte mediated immunity (GO:0002707)3.03067250
149Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03048230
150respiratory burst (GO:0045730)3.00580980
151regulation of interferon-beta biosynthetic process (GO:0045357)2.99407114
152T cell migration (GO:0072678)2.98995141
153negative regulation of phagocytosis (GO:0050765)2.98090014
154response to host immune response (GO:0052572)2.96163743
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96163743
156negative regulation of leukocyte mediated immunity (GO:0002704)2.96149179
157defense response to protozoan (GO:0042832)2.95446778
158cellular response to type I interferon (GO:0071357)2.93910539
159type I interferon signaling pathway (GO:0060337)2.93910539
160response to type I interferon (GO:0034340)2.93504595
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90554161
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89843387
163response to host (GO:0075136)2.89843387
164response to host defenses (GO:0052200)2.89843387
165regulation of leukocyte degranulation (GO:0043300)2.88987099
166cellular extravasation (GO:0045123)2.86731560
167B cell mediated immunity (GO:0019724)2.85391748
168regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84234727
169negative regulation of innate immune response (GO:0045824)2.83283694
170response to interleukin-15 (GO:0070672)2.82280992
171antigen processing and presentation via MHC class Ib (GO:0002475)2.81389056
172response to protozoan (GO:0001562)2.80284126
173mature B cell differentiation involved in immune response (GO:0002313)2.78575141
174negative regulation of T cell mediated immunity (GO:0002710)2.77471890
175detection of biotic stimulus (GO:0009595)2.75495190
176modulation by virus of host process (GO:0019054)2.75004683
177regulation of antigen processing and presentation (GO:0002577)2.74302193
178positive regulation of antigen processing and presentation (GO:0002579)2.72873452
179B cell homeostasis (GO:0001782)2.70112001
180regulation of necroptotic process (GO:0060544)2.69688090
181regulation of mast cell activation involved in immune response (GO:0033006)2.68253287
182regulation of interleukin-2 biosynthetic process (GO:0045076)2.67376416
183regulation of alpha-beta T cell proliferation (GO:0046640)2.67277975
184myeloid cell activation involved in immune response (GO:0002275)2.66372142
185negative regulation of B cell apoptotic process (GO:0002903)2.66314965
186neutrophil activation (GO:0042119)2.62294865
187lymphocyte homeostasis (GO:0002260)2.57535962
188regulation of necrotic cell death (GO:0010939)2.55696251
189regulation of T cell tolerance induction (GO:0002664)2.55519343
190myeloid dendritic cell activation (GO:0001773)2.54172428
191interferon-gamma-mediated signaling pathway (GO:0060333)2.54002033
192positive regulation of Cdc42 GTPase activity (GO:0043089)2.53839449
193lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53781607
194modulation by symbiont of host cellular process (GO:0044068)2.53582620
195antigen receptor-mediated signaling pathway (GO:0050851)2.53241943
196T cell homeostasis (GO:0043029)2.51292771
197regulation of superoxide anion generation (GO:0032928)2.48192170
198myeloid dendritic cell differentiation (GO:0043011)2.47544760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.01695026
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.63451389
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.21359590
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.27979500
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27328877
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.83483034
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.77353454
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.42824967
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98111543
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.78060030
11GATA1_22025678_ChIP-Seq_K562_Human2.55499513
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45517559
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34574752
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31140714
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.27863887
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26659422
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.20154596
18* KDM2B_26808549_Chip-Seq_DND41_Human2.10501241
19MAF_26560356_Chip-Seq_TH2_Human1.97289459
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97125044
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.91798978
22CLOCK_20551151_ChIP-Seq_293T_Human1.89616820
23RUNX1_22412390_ChIP-Seq_EML_Mouse1.87622623
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85265300
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77666772
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76999604
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.69136903
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66063480
29SPI1_23547873_ChIP-Seq_NB4_Human1.66049859
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60510204
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.60150282
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59232211
33* MYC_22102868_ChIP-Seq_BL_Human1.58085208
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55441674
35LXR_22292898_ChIP-Seq_THP-1_Human1.52939311
36* MYB_26560356_Chip-Seq_TH2_Human1.50423361
37BCL6_27268052_Chip-Seq_Bcells_Human1.48623978
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.47316983
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45867181
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45386757
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45272138
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44834811
43CIITA_25753668_ChIP-Seq_RAJI_Human1.44735024
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42677379
45PU.1_20513432_ChIP-Seq_Bcells_Mouse1.40524784
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40121043
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39447656
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38918317
49* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37096820
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35636997
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34701163
52SPI1_23127762_ChIP-Seq_K562_Human1.33332163
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33002708
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31993502
55* NCOR1_26117541_ChIP-Seq_K562_Human1.30227810
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28957740
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26095241
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25862244
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25499975
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25361631
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24715180
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24488501
63VDR_21846776_ChIP-Seq_THP-1_Human1.24320479
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24036515
65RUNX_20019798_ChIP-Seq_JUKART_Human1.22487784
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.22413187
67GATA4_25053715_ChIP-Seq_YYC3_Human1.21358744
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.17288871
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.15836871
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14811877
71RACK7_27058665_Chip-Seq_MCF-7_Human1.14811722
72CTCF_26484167_Chip-Seq_Bcells_Mouse1.14725527
73SMC4_20622854_ChIP-Seq_HELA_Human1.14514785
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14491637
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13273579
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13016126
77GATA6_25053715_ChIP-Seq_YYC3_Human1.12272336
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11597726
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11460495
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10322031
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10003809
82KDM2B_26808549_Chip-Seq_K562_Human1.08849374
83E2F7_22180533_ChIP-Seq_HELA_Human1.05299701
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03797160
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03410463
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03262132
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02138150
88PHF8_20622854_ChIP-Seq_HELA_Human1.02104414
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01874529
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01778474
91* UTX_26944678_Chip-Seq_JUKART_Human1.01701198
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01210722
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00916308
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00322975
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99736726
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99529370
97ZNF263_19887448_ChIP-Seq_K562_Human0.99447273
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98094488
99HNF4A_19822575_ChIP-Seq_HepG2_Human0.97609442
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97244012
101* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97059304
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97007440
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.96019140
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94818485
105MAF_26560356_Chip-Seq_TH1_Human0.94233836
106* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93641677
107TCF7_22412390_ChIP-Seq_EML_Mouse0.93284736
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92768381
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92286512
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92225060
111ATF3_27146783_Chip-Seq_COLON_Human0.91725754
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91117507
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.90808279
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90598998
115BCOR_27268052_Chip-Seq_Bcells_Human0.90438230
116ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90218063
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89549256
118P68_20966046_ChIP-Seq_HELA_Human0.88795707
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.88449495
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88002148
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87861223
122RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87748413
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87045520
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86136506
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85929249
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84568323
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84556389
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.84411394
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84379513
130* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84261928
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83951869
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83823140
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.83674370
134GATA1_19941826_ChIP-Seq_K562_Human0.80950593
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80325672
136MYB_26560356_Chip-Seq_TH1_Human0.80274322
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.79964098
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79679179
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79359391
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.78957514
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.78957514
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78596888
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78471281
144VDR_24763502_ChIP-Seq_THP-1_Human0.78192488
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.77757542
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77688107
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77450279
148CREB1_26743006_Chip-Seq_LNCaP_Human0.76914140
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76891145
150SCL_19346495_ChIP-Seq_HPC-7_Human0.76436715
151P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76260501
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75889935
153CTCF_21964334_Chip-Seq_Bcells_Human0.75845242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.22190537
2MP0005365_abnormal_bile_salt5.31629079
3MP0005360_urolithiasis5.00255549
4MP0005085_abnormal_gallbladder_physiolo4.53716015
5MP0005083_abnormal_biliary_tract3.71015826
6MP0001666_abnormal_nutrient_absorption3.57229679
7MP0003252_abnormal_bile_duct3.28710702
8MP0008875_abnormal_xenobiotic_pharmacok3.17920199
9MP0001835_abnormal_antigen_presentation3.14560189
10MP0003763_abnormal_thymus_physiology3.14538054
11MP0003806_abnormal_nucleotide_metabolis2.89731344
12MP0003195_calcinosis2.83217443
13MP0009840_abnormal_foam_cell2.79893271
14MP0005220_abnormal_exocrine_pancreas2.79748105
15MP0009278_abnormal_bone_marrow2.73657720
16MP0001800_abnormal_humoral_immune2.70678583
17MP0005000_abnormal_immune_tolerance2.61915460
18MP0005671_abnormal_response_to2.61592386
19MP0010329_abnormal_lipoprotein_level2.57876555
20MP0009333_abnormal_splenocyte_physiolog2.45301816
21MP0002419_abnormal_innate_immunity2.42776502
22MP0002420_abnormal_adaptive_immunity2.38469776
23MP0002723_abnormal_immune_serum2.36505349
24MP0001819_abnormal_immune_cell2.36166201
25MP0002452_abnormal_antigen_presenting2.31216557
26MP0008260_abnormal_autophagy2.28470762
27MP0003868_abnormal_feces_composition2.25463797
28MP0005332_abnormal_amino_acid2.21930111
29MP0002396_abnormal_hematopoietic_system2.18381778
30MP0002398_abnormal_bone_marrow2.17425497
31MP0003191_abnormal_cellular_cholesterol2.15554621
32MP0009785_altered_susceptibility_to1.99834496
33MP0000716_abnormal_immune_system1.97301381
34MP0000609_abnormal_liver_physiology1.93051121
35MP0002148_abnormal_hypersensitivity_rea1.90589901
36MP0009643_abnormal_urine_homeostasis1.89226245
37MP0002693_abnormal_pancreas_physiology1.88115623
38MP0002118_abnormal_lipid_homeostasis1.85145894
39MP0002405_respiratory_system_inflammati1.85076517
40MP0001944_abnormal_pancreas_morphology1.81874626
41MP0000703_abnormal_thymus_morphology1.81637514
42MP0003300_gastrointestinal_ulcer1.80246394
43MP0002138_abnormal_hepatobiliary_system1.78967495
44MP0002722_abnormal_immune_system1.77414772
45MP0002429_abnormal_blood_cell1.70634408
46MP0000465_gastrointestinal_hemorrhage1.70381333
47MP0000689_abnormal_spleen_morphology1.70352633
48MP0004264_abnormal_extraembryonic_tissu1.66650734
49MP0005397_hematopoietic_system_phenotyp1.65701476
50MP0001545_abnormal_hematopoietic_system1.65701476
51MP0001533_abnormal_skeleton_physiology1.63487240
52MP0000858_altered_metastatic_potential1.61987400
53MP0005319_abnormal_enzyme/_coenzyme1.60124449
54MP0003705_abnormal_hypodermis_morpholog1.53946094
55MP0002132_abnormal_respiratory_system1.51567393
56MP0004043_abnormal_pH_regulation1.50979673
57MP0002078_abnormal_glucose_homeostasis1.46340446
58MP0006082_CNS_inflammation1.46298150
59MP0000490_abnormal_crypts_of1.42897346
60MP0001764_abnormal_homeostasis1.40826939
61MP0002877_abnormal_melanocyte_morpholog1.40004907
62MP0004019_abnormal_vitamin_homeostasis1.38296189
63MP0005058_abnormal_lysosome_morphology1.36825933
64MP0005076_abnormal_cell_differentiation1.34984803
65MP0001853_heart_inflammation1.31238131
66MP0004808_abnormal_hematopoietic_stem1.31128567
67MP0005636_abnormal_mineral_homeostasis1.27798037
68MP0004510_myositis1.25072610
69MP0002933_joint_inflammation1.22259047
70MP0004381_abnormal_hair_follicle1.22055998
71MP0005310_abnormal_salivary_gland1.21024828
72MP0010234_abnormal_vibrissa_follicle1.20218392
73MP0003283_abnormal_digestive_organ1.19979322
74MP0004185_abnormal_adipocyte_glucose1.18695587
75MP0000598_abnormal_liver_morphology1.16949590
76MP0002909_abnormal_adrenal_gland1.15639481
77MP0005584_abnormal_enzyme/coenzyme_acti1.13788276
78MP0001849_ear_inflammation1.13587827
79MP0001851_eye_inflammation1.12707229
80MP0002837_dystrophic_cardiac_calcinosis1.12209440
81MP0003183_abnormal_peptide_metabolism1.10720512
82MP0005084_abnormal_gallbladder_morpholo1.07532695
83MP0004858_abnormal_nervous_system1.06345327
84MP0001756_abnormal_urination1.06294006
85MP0002998_abnormal_bone_remodeling1.05765087
86MP0002928_abnormal_bile_duct1.05000151
87MP0008469_abnormal_protein_level1.01883588
88MP0003453_abnormal_keratinocyte_physiol0.99576503
89MP0003186_abnormal_redox_activity0.99334542
90MP0002019_abnormal_tumor_incidence0.98698891
91MP0009642_abnormal_blood_homeostasis0.98483748
92MP0001765_abnormal_ion_homeostasis0.98337407
93MP0006036_abnormal_mitochondrial_physio0.96053159
94MP0005451_abnormal_body_composition0.95858509
95MP0005670_abnormal_white_adipose0.95209198
96MP0003959_abnormal_lean_body0.95151211
97MP0003828_pulmonary_edema0.94290993
98MP0001663_abnormal_digestive_system0.92061122
99MP0003436_decreased_susceptibility_to0.91563649
100MP0003075_altered_response_to0.90438461
101MP0000013_abnormal_adipose_tissue0.89695348
102MP0005166_decreased_susceptibility_to0.84869163
103MP0003656_abnormal_erythrocyte_physiolo0.84073374
104MP0005408_hypopigmentation0.83578076
105MP0008961_abnormal_basal_metabolism0.83142853
106MP0001845_abnormal_inflammatory_respons0.83055777
107MP0002166_altered_tumor_susceptibility0.82726314
108MP0009763_increased_sensitivity_to0.81588093
109MP0000003_abnormal_adipose_tissue0.79861366
110MP0005390_skeleton_phenotype0.79744243
111MP0004947_skin_inflammation0.78888052
112MP0001348_abnormal_lacrimal_gland0.77845646
113MP0003953_abnormal_hormone_level0.76930977
114MP0005448_abnormal_energy_balance0.76252520
115MP0006054_spinal_hemorrhage0.76104582
116MP0005334_abnormal_fat_pad0.75911339
117MP0004130_abnormal_muscle_cell0.75512010
118MP0002136_abnormal_kidney_physiology0.73853246
119MP0005464_abnormal_platelet_physiology0.72445588
120MP0009764_decreased_sensitivity_to0.71925923
121MP0000313_abnormal_cell_death0.71774520
122MP0005075_abnormal_melanosome_morpholog0.70782749
123MP0002006_tumorigenesis0.70757253
124MP0000678_abnormal_parathyroid_gland0.69986441
125MP0002971_abnormal_brown_adipose0.69313762
126MP0002009_preneoplasia0.68878754
127MP0009931_abnormal_skin_appearance0.68647974
128MP0003172_abnormal_lysosome_physiology0.68495879
129MP0003448_altered_tumor_morphology0.66939441
130MP0002796_impaired_skin_barrier0.66242036
131MP0005621_abnormal_cell_physiology0.65976956
132MP0003091_abnormal_cell_migration0.65936153
133MP0005375_adipose_tissue_phenotype0.65553601
134MP0001873_stomach_inflammation0.65032409
135MP0009765_abnormal_xenobiotic_induced0.64961636
136MP0000604_amyloidosis0.64304486
137MP0005501_abnormal_skin_physiology0.62880161
138MP0003795_abnormal_bone_structure0.62463880
139MP0005381_digestive/alimentary_phenotyp0.61773886
140MP0003303_peritoneal_inflammation0.60494448
141MP0000681_abnormal_thyroid_gland0.60297545
142MP0008874_decreased_physiological_sensi0.60206379
143MP0003866_abnormal_defecation0.60066201
144MP0010386_abnormal_urinary_bladder0.59963697
145MP0003111_abnormal_nucleus_morphology0.59786434
146MP0005666_abnormal_adipose_tissue0.59129683
147MP0005535_abnormal_body_temperature0.58838493
148MP0010155_abnormal_intestine_physiology0.58424118
149MP0005647_abnormal_sex_gland0.58175762
150MP0001661_extended_life_span0.57219752
151MP0003638_abnormal_response/metabolism_0.56918307
152MP0001881_abnormal_mammary_gland0.56702562
153MP0000477_abnormal_intestine_morphology0.56581367
154MP0000613_abnormal_salivary_gland0.56572254
155MP0009780_abnormal_chondrocyte_physiolo0.55144956
156MP0000685_abnormal_immune_system0.54777233
157MP0003724_increased_susceptibility_to0.54760335
158MP0001790_abnormal_immune_system0.54326387
159MP0005387_immune_system_phenotype0.54326387
160MP0004782_abnormal_surfactant_physiolog0.53847818
161MP0002970_abnormal_white_adipose0.53688385
162MP0005025_abnormal_response_to0.52422734
163MP0009672_abnormal_birth_weight0.51500401
164MP0002896_abnormal_bone_mineralization0.50306388
165MP0003566_abnormal_cell_adhesion0.48602752
166MP0005379_endocrine/exocrine_gland_phen0.48418957
167MP0002269_muscular_atrophy0.48378574

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.05883541
2Eczematoid dermatitis (HP:0000976)5.54827015
3Hypoglycemic coma (HP:0001325)5.51282038
4Intrahepatic cholestasis (HP:0001406)4.86081485
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.64601433
6Deep venous thrombosis (HP:0002625)4.59352216
7Ketosis (HP:0001946)4.43736883
8Xanthomatosis (HP:0000991)4.42296105
9Abnormality of the intrinsic pathway (HP:0010989)4.39392897
10Recurrent abscess formation (HP:0002722)4.38267009
11Ketoacidosis (HP:0001993)4.30653545
12Hypoglycemic seizures (HP:0002173)4.30618802
13Recurrent bacterial skin infections (HP:0005406)4.30321173
14Prolonged partial thromboplastin time (HP:0003645)4.25382367
15Hyperinsulinemic hypoglycemia (HP:0000825)4.22273650
16Abnormality of the common coagulation pathway (HP:0010990)4.14011044
17Hypobetalipoproteinemia (HP:0003563)3.94351940
18Cellulitis (HP:0100658)3.88333038
19Abnormality of macrophages (HP:0004311)3.87758615
20Increased IgE level (HP:0003212)3.83020991
21Mediastinal lymphadenopathy (HP:0100721)3.77482214
22Recurrent fungal infections (HP:0002841)3.77189857
23Elevated erythrocyte sedimentation rate (HP:0003565)3.76384062
24Myositis (HP:0100614)3.75506839
25Meningitis (HP:0001287)3.73923542
26Panhypogammaglobulinemia (HP:0003139)3.67783747
27Chronic obstructive pulmonary disease (HP:0006510)3.67379476
28Obstructive lung disease (HP:0006536)3.67379476
29Agammaglobulinemia (HP:0004432)3.62144305
30Late onset (HP:0003584)3.60118558
31Fat malabsorption (HP:0002630)3.56903856
32Hyperlipoproteinemia (HP:0010980)3.52074485
33Symptomatic seizures (HP:0011145)3.46726157
34Colitis (HP:0002583)3.45939167
35Recurrent viral infections (HP:0004429)3.44517580
36Complement deficiency (HP:0004431)3.43956398
37Abnormality of endocrine pancreas physiology (HP:0012093)3.43135032
38Abnormality of the pancreatic islet cells (HP:0006476)3.43135032
39Hyperammonemia (HP:0001987)3.42024578
40Generalized aminoaciduria (HP:0002909)3.41417529
41Gastrointestinal inflammation (HP:0004386)3.36595151
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34805269
43Abnormal delayed hypersensitivity skin test (HP:0002963)3.34534928
44Abnormality of fatty-acid metabolism (HP:0004359)3.29097850
45Abnormality of sulfur amino acid metabolism (HP:0004339)3.19469218
46Conjugated hyperbilirubinemia (HP:0002908)3.15619301
47Gout (HP:0001997)3.14425496
48Joint hemorrhage (HP:0005261)3.13276206
49Pustule (HP:0200039)3.09161489
50Inflammation of the large intestine (HP:0002037)3.08495380
51Hyperglycinemia (HP:0002154)3.07256274
52Hyperglycinuria (HP:0003108)3.01036273
53Hypolipoproteinemia (HP:0010981)2.99782011
54Orchitis (HP:0100796)2.97833771
55Recurrent skin infections (HP:0001581)2.94431979
56Recurrent cutaneous fungal infections (HP:0011370)2.91693773
57Chronic mucocutaneous candidiasis (HP:0002728)2.91693773
58Abnormality of purine metabolism (HP:0004352)2.91514223
59Hyperglycemia (HP:0003074)2.91124337
60Gastrointestinal infarctions (HP:0005244)2.88441756
61Pancreatic islet-cell hyperplasia (HP:0004510)2.86812916
62Abnormality of serine family amino acid metabolism (HP:0010894)2.86778263
63Abnormality of glycine metabolism (HP:0010895)2.86778263
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86436599
65Gastrointestinal stroma tumor (HP:0100723)2.79833194
66Steatorrhea (HP:0002570)2.78342789
67Gingivitis (HP:0000230)2.76601880
68Vasculitis (HP:0002633)2.75954977
69Granulocytopenia (HP:0001913)2.75072485
70Stomatitis (HP:0010280)2.73003871
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71152989
72Epidermoid cyst (HP:0200040)2.71106398
73Encephalitis (HP:0002383)2.67665971
74Abnormality of nucleobase metabolism (HP:0010932)2.67592095
75Dicarboxylic aciduria (HP:0003215)2.66505016
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66505016
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66293018
78Hypoalphalipoproteinemia (HP:0003233)2.64254905
79Abnormality of methionine metabolism (HP:0010901)2.61360070
80Urticaria (HP:0001025)2.60472215
81Abnormality of complement system (HP:0005339)2.60231822
82Hyperbilirubinemia (HP:0002904)2.60111477
83Prolonged bleeding time (HP:0003010)2.58965040
84Verrucae (HP:0200043)2.56406703
85Papilloma (HP:0012740)2.56406703
86Mucopolysacchariduria (HP:0008155)2.54880730
87Urinary glycosaminoglycan excretion (HP:0003541)2.54880730
88Pancreatitis (HP:0001733)2.50766097
89Petechiae (HP:0000967)2.50642181
90Lymphopenia (HP:0001888)2.48992842
91Osteomyelitis (HP:0002754)2.44327627
92Retrobulbar optic neuritis (HP:0100654)2.42796194
93Optic neuritis (HP:0100653)2.42796194
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.42582447
95Hypertensive crisis (HP:0100735)2.41503643
96Increased IgM level (HP:0003496)2.39848953
97Chest pain (HP:0100749)2.39837131
98Myoglobinuria (HP:0002913)2.39499175
99Abnormality of T cell physiology (HP:0011840)2.38528117
100Abnormality of T cells (HP:0002843)2.36483658
101Myocardial infarction (HP:0001658)2.34333933
102Dysostosis multiplex (HP:0000943)2.34219950
103Insulin resistance (HP:0000855)2.31709458
104Metabolic acidosis (HP:0001942)2.31109128
105Vacuolated lymphocytes (HP:0001922)2.30709604
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29530942
107Abnormality of polysaccharide metabolism (HP:0011012)2.29530942
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29530942
109Skin nodule (HP:0200036)2.29361673
110Spontaneous hematomas (HP:0007420)2.29307240
111Sepsis (HP:0100806)2.29069937
112Increased serum ferritin (HP:0003281)2.28205798
113Epistaxis (HP:0000421)2.24267069
114Ragged-red muscle fibers (HP:0003200)2.24062834
115Increased cerebral lipofuscin (HP:0011813)2.23093812
116Polygenic inheritance (HP:0010982)2.20638624
117Abnormality of pyrimidine metabolism (HP:0004353)2.19747840
118Insulin-resistant diabetes mellitus (HP:0000831)2.17863886
119Menorrhagia (HP:0000132)2.17349735
120Hypergammaglobulinemia (HP:0010702)2.17286805
121Hepatosplenomegaly (HP:0001433)2.17233654
122Abnormality of the fingertips (HP:0001211)2.17172366
123Emphysema (HP:0002097)2.16900517
124Large for gestational age (HP:0001520)2.16722253
125Thoracic kyphosis (HP:0002942)2.14956719
126IgM deficiency (HP:0002850)2.14266623
127Broad face (HP:0000283)2.13796437
128Seborrheic dermatitis (HP:0001051)2.13347466
129Hepatocellular carcinoma (HP:0001402)2.12821631
130Hypercholesterolemia (HP:0003124)2.09413170
131Increased neuronal autofluorescent lipopigment (HP:0002074)2.07107918
132Skin ulcer (HP:0200042)2.06541601
133Purpura (HP:0000979)2.05526122
134Pulmonary infiltrates (HP:0002113)2.04243991
135Aplasia/Hypoplasia of the thymus (HP:0010515)2.04194327
136Loss of speech (HP:0002371)2.03775388
137Viral hepatitis (HP:0006562)2.01786775
138Protuberant abdomen (HP:0001538)2.01470776
139Severe combined immunodeficiency (HP:0004430)1.99867132
140Abnormal enzyme/coenzyme activity (HP:0012379)1.99810379
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99130593
142Hypochromic anemia (HP:0001931)1.98866140
143Autoimmune hemolytic anemia (HP:0001890)1.98016195
144Leukocytosis (HP:0001974)1.97743874
145Abdominal distention (HP:0003270)1.97664604
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97124544
147Acute hepatic failure (HP:0006554)1.96930360
148Premature loss of primary teeth (HP:0006323)1.96692197
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.95997244
150Hypertriglyceridemia (HP:0002155)1.95670488
151Abnormality of serum amino acid levels (HP:0003112)1.94360354
152T lymphocytopenia (HP:0005403)1.94256596
153Elevated alkaline phosphatase (HP:0003155)1.93590061
154Mitral stenosis (HP:0001718)1.92901083
155Irritability (HP:0000737)1.92316997
156Easy fatigability (HP:0003388)1.91856721
157Restrictive lung disease (HP:0002091)1.91668065
158Skin rash (HP:0000988)1.91645791
159Fatigue (HP:0012378)1.91576740
160Lethargy (HP:0001254)1.91557276
161Abnormality of the thoracic spine (HP:0100711)1.91422384
162Death in childhood (HP:0003819)1.91003378
163Hemoptysis (HP:0002105)1.89745452
164Abnormal gallbladder morphology (HP:0012437)1.88422192
165Abnormality of alkaline phosphatase activity (HP:0004379)1.88296822
166Obstructive sleep apnea (HP:0002870)1.87687085
167Recurrent lower respiratory tract infections (HP:0002783)1.86707100
168Limb hypertonia (HP:0002509)1.86392445
169Hemorrhage of the eye (HP:0011885)1.86336566
170Nasal polyposis (HP:0100582)1.85716234
171Delayed CNS myelination (HP:0002188)1.85119172
172Vascular calcification (HP:0004934)1.84634919
173Slow saccadic eye movements (HP:0000514)1.84572107
174Esophageal varix (HP:0002040)1.84522089
175Proximal tubulopathy (HP:0000114)1.83675929
176Abnormality of urine glucose concentration (HP:0011016)1.83653295
177Glycosuria (HP:0003076)1.83653295
178Malnutrition (HP:0004395)1.83204198
179Systemic lupus erythematosus (HP:0002725)1.82401828
180Spastic diplegia (HP:0001264)1.81738173
181Brushfield spots (HP:0001088)1.81660838
182Keratoconjunctivitis sicca (HP:0001097)1.81403057
183Recurrent gram-negative bacterial infections (HP:0005420)1.81321810
184Abnormality of transition element cation homeostasis (HP:0011030)1.81274022
185Interstitial pulmonary disease (HP:0006530)1.81044048
186Episodic fever (HP:0001954)1.81031392
187Abnormal tarsal ossification (HP:0008369)1.80723924
188Hyperuricemia (HP:0002149)1.80658870
189Increased purine levels (HP:0004368)1.80658870
190Stridor (HP:0010307)1.80563957
191Abnormality of T cell number (HP:0011839)1.80362217
192Abnormal cartilage morphology (HP:0002763)1.78276647
193Abnormality of the nasal mucosa (HP:0000433)1.77636195
194Exocrine pancreatic insufficiency (HP:0001738)1.77124719
195Reduced antithrombin III activity (HP:0001976)1.76972814
196Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76199707
197Thin bony cortex (HP:0002753)1.75280531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.79985179
2BCKDK5.02263768
3INSRR3.69155211
4TAOK33.56811214
5TRIB33.48424156
6PRPF4B3.39645869
7PKN22.97714497
8SMG12.83101899
9FLT32.69451258
10SIK12.67889935
11RIPK42.67123071
12FGFR42.57165347
13PASK2.51485808
14MAPK152.04915440
15PTK61.87836131
16TNK21.82807084
17MAP3K131.80707592
18EEF2K1.75701214
19FRK1.75448789
20IRAK31.74779035
21FES1.65381275
22MAP4K11.58228422
23MAP2K21.56698729
24MAP3K141.56045928
25ZAP701.52454606
26SIK31.51071669
27TYK21.50369622
28MAP3K101.49818288
29CDK121.47819505
30PIK3CG1.34591678
31HIPK21.33273487
32TAOK21.24959317
33EIF2AK31.24125285
34ICK1.23729067
35SIK21.21244890
36TBK11.20141865
37MAP2K31.19763602
38TAOK11.16413605
39KDR1.16180918
40EPHB11.16180216
41JAK31.15883328
42MAP3K21.10224730
43MAP3K31.09709525
44JAK11.09567370
45HCK1.07476200
46SCYL21.04808515
47MAPK111.03225842
48LRRK21.02226259
49CDK41.00401646
50EPHA30.99785231
51MARK20.99680900
52IKBKB0.99253628
53MAPKAPK30.99238093
54JAK20.97988527
55TXK0.96749752
56TTN0.96749636
57RIPK10.95920600
58BTK0.95493139
59NME20.93957875
60WNK40.92960652
61MAP3K10.88960939
62LYN0.88309727
63PTK20.87075059
64DYRK1B0.83171131
65MAP3K60.83009945
66BLK0.82586369
67IRAK20.80417874
68IRAK40.80060447
69PDGFRA0.76763081
70MAPK120.76186572
71ITK0.75113940
72LATS10.71880747
73TGFBR20.71748491
74MARK30.71689940
75IRAK10.70855189
76MST1R0.68484941
77PDK10.66082833
78RPS6KA40.66069907
79EPHA20.65844853
80CSK0.64951289
81IKBKE0.64690115
82GRK60.63902068
83MTOR0.62731937
84CAMKK10.61867238
85MATK0.60611324
86ARAF0.59321154
87RET0.59220673
88FGR0.57199108
89MAPK70.55202372
90PRKCH0.54892563
91NLK0.54015458
92MAP3K110.52553731
93MAP3K70.52115054
94MET0.51298936
95KSR20.51258532
96BMX0.50304286
97RPS6KB20.48438619
98PIM10.47941312
99PIM20.47487503
100RPS6KA20.47179035
101PRKAA20.46556391
102TESK10.46069625
103PAK20.45803513
104MAPKAPK20.44414214
105GSK3A0.41581115
106MYLK0.40992105
107CDK70.40806795
108PRKAA10.39286020
109MAP2K10.39126951
110TESK20.38697136
111FGFR30.37265775
112KIT0.36699314
113MAPK40.36686570
114PRKD10.36497996
115NEK90.36104730
116TEC0.35669030
117PDPK10.35640891
118CDK90.34447331
119ERBB40.34111080
120PRKCI0.33708100
121MAP3K80.33572266
122RPS6KA10.32992844
123FYN0.32205704
124CDC42BPA0.31856970
125SYK0.31764879
126CSF1R0.31133119
127RPS6KA60.29591693
128MAP2K60.29539449
129RPS6KL10.29025532
130RPS6KC10.29025532
131PRKD20.28999544
132STK100.28771140
133BRSK20.26528736
134CHUK0.25836500
135CAMK1D0.25408989
136PRKACG0.23954972
137FER0.23454884
138ILK0.23247032
139LCK0.22480748

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.06942031
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.36379490
3Primary immunodeficiency_Homo sapiens_hsa053403.01176058
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77643057
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64180601
6B cell receptor signaling pathway_Homo sapiens_hsa046622.64113247
7Tryptophan metabolism_Homo sapiens_hsa003802.61713458
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58132931
9Fatty acid degradation_Homo sapiens_hsa000712.54576911
10Leishmaniasis_Homo sapiens_hsa051402.49257310
11Osteoclast differentiation_Homo sapiens_hsa043802.37370510
12Allograft rejection_Homo sapiens_hsa053302.36734361
13Arginine biosynthesis_Homo sapiens_hsa002202.28999207
14Protein export_Homo sapiens_hsa030602.28727201
15Selenocompound metabolism_Homo sapiens_hsa004502.26385354
16Sulfur metabolism_Homo sapiens_hsa009202.24967947
17Graft-versus-host disease_Homo sapiens_hsa053322.22199293
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20373737
19Autoimmune thyroid disease_Homo sapiens_hsa053202.20294216
20Nitrogen metabolism_Homo sapiens_hsa009102.19765278
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14109808
22Fat digestion and absorption_Homo sapiens_hsa049751.99509532
23Folate biosynthesis_Homo sapiens_hsa007901.95690708
24Complement and coagulation cascades_Homo sapiens_hsa046101.90822655
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.88950977
26Propanoate metabolism_Homo sapiens_hsa006401.88069743
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86329509
28Peroxisome_Homo sapiens_hsa041461.85028937
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84768037
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80074975
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.77568495
32Butanoate metabolism_Homo sapiens_hsa006501.77294633
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73512165
34Herpes simplex infection_Homo sapiens_hsa051681.71065323
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70198194
36T cell receptor signaling pathway_Homo sapiens_hsa046601.68635035
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66625001
38Caffeine metabolism_Homo sapiens_hsa002321.66191654
39Viral myocarditis_Homo sapiens_hsa054161.65300390
40Fatty acid metabolism_Homo sapiens_hsa012121.64611925
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63909953
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63875515
43Histidine metabolism_Homo sapiens_hsa003401.63496375
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62550843
45Tuberculosis_Homo sapiens_hsa051521.61112863
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58763671
47Non-small cell lung cancer_Homo sapiens_hsa052231.58470663
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57929559
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.53243129
50Type I diabetes mellitus_Homo sapiens_hsa049401.51175172
51Chronic myeloid leukemia_Homo sapiens_hsa052201.51028899
52Influenza A_Homo sapiens_hsa051641.50585152
53Measles_Homo sapiens_hsa051621.50294326
54beta-Alanine metabolism_Homo sapiens_hsa004101.49895891
55Starch and sucrose metabolism_Homo sapiens_hsa005001.49270233
56Asthma_Homo sapiens_hsa053101.48930346
57Toxoplasmosis_Homo sapiens_hsa051451.48062319
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46813684
59PPAR signaling pathway_Homo sapiens_hsa033201.44357563
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.41240146
61ABC transporters_Homo sapiens_hsa020101.41199109
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39669939
63Notch signaling pathway_Homo sapiens_hsa043301.39109166
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38797535
65Hematopoietic cell lineage_Homo sapiens_hsa046401.35189357
66Pancreatic cancer_Homo sapiens_hsa052121.34340210
67Phenylalanine metabolism_Homo sapiens_hsa003601.33152575
68TNF signaling pathway_Homo sapiens_hsa046681.30709072
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29415992
70Sulfur relay system_Homo sapiens_hsa041221.28787677
71VEGF signaling pathway_Homo sapiens_hsa043701.28220388
72Hepatitis B_Homo sapiens_hsa051611.25421409
73NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24559639
74Pyruvate metabolism_Homo sapiens_hsa006201.23074175
75Chemical carcinogenesis_Homo sapiens_hsa052041.22091588
76Staphylococcus aureus infection_Homo sapiens_hsa051501.18301704
77Carbon metabolism_Homo sapiens_hsa012001.15524188
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15200649
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15119013
80Apoptosis_Homo sapiens_hsa042101.14807383
81Epstein-Barr virus infection_Homo sapiens_hsa051691.14398671
82Biosynthesis of amino acids_Homo sapiens_hsa012301.13193814
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10009062
84Shigellosis_Homo sapiens_hsa051311.09798680
85Chemokine signaling pathway_Homo sapiens_hsa040621.09190380
86HTLV-I infection_Homo sapiens_hsa051661.07594480
87Bile secretion_Homo sapiens_hsa049761.07257231
88Hepatitis C_Homo sapiens_hsa051601.07097829
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04110488
90Tyrosine metabolism_Homo sapiens_hsa003501.03898936
91Leukocyte transendothelial migration_Homo sapiens_hsa046701.02707300
92Viral carcinogenesis_Homo sapiens_hsa052031.02459472
93Base excision repair_Homo sapiens_hsa034101.01923948
94N-Glycan biosynthesis_Homo sapiens_hsa005101.01022953
95Lysine degradation_Homo sapiens_hsa003101.00095929
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99652413
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.99535683
98Arginine and proline metabolism_Homo sapiens_hsa003300.98961307
99Malaria_Homo sapiens_hsa051440.98440305
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.97443743
101Other glycan degradation_Homo sapiens_hsa005110.96999939
102Fatty acid elongation_Homo sapiens_hsa000620.93928496
103Retinol metabolism_Homo sapiens_hsa008300.93569864
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.92952824
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.88956993
106Glycerolipid metabolism_Homo sapiens_hsa005610.88518516
107Pertussis_Homo sapiens_hsa051330.87145291
108One carbon pool by folate_Homo sapiens_hsa006700.80153660
109Platelet activation_Homo sapiens_hsa046110.79878047
110mTOR signaling pathway_Homo sapiens_hsa041500.79075476
111Galactose metabolism_Homo sapiens_hsa000520.79070521
112Pancreatic secretion_Homo sapiens_hsa049720.78144127
113Insulin resistance_Homo sapiens_hsa049310.78091694
114Vitamin digestion and absorption_Homo sapiens_hsa049770.77620591
115DNA replication_Homo sapiens_hsa030300.77603251
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77167697
117Salmonella infection_Homo sapiens_hsa051320.76653889
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76224230
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73525734
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72768751
121Colorectal cancer_Homo sapiens_hsa052100.72604346
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71060494
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.69910890
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.68978165
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67196407
126Pentose phosphate pathway_Homo sapiens_hsa000300.67138404
127Fructose and mannose metabolism_Homo sapiens_hsa000510.66610797
128Phagosome_Homo sapiens_hsa041450.65853543
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65750612
130Endocytosis_Homo sapiens_hsa041440.64102896
131Choline metabolism in cancer_Homo sapiens_hsa052310.62236436
132Endometrial cancer_Homo sapiens_hsa052130.61689054
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.61396691
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60622667
135Protein digestion and absorption_Homo sapiens_hsa049740.60222574
136Rheumatoid arthritis_Homo sapiens_hsa053230.60209058
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.59540836
138Inositol phosphate metabolism_Homo sapiens_hsa005620.59036170
139Ribosome_Homo sapiens_hsa030100.58995558
140Steroid biosynthesis_Homo sapiens_hsa001000.57334248
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57111694
142African trypanosomiasis_Homo sapiens_hsa051430.56554556
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54926268
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54658653
145Lysosome_Homo sapiens_hsa041420.54222284
146Renal cell carcinoma_Homo sapiens_hsa052110.54140557
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53858471
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53403663
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51695933
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50665583
151Glutathione metabolism_Homo sapiens_hsa004800.50139237
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49791051
153Small cell lung cancer_Homo sapiens_hsa052220.46084104
154Metabolic pathways_Homo sapiens_hsa011000.45429307
155Thyroid cancer_Homo sapiens_hsa052160.45400547
156HIF-1 signaling pathway_Homo sapiens_hsa040660.45201598
157GnRH signaling pathway_Homo sapiens_hsa049120.44338252
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.42866112
159FoxO signaling pathway_Homo sapiens_hsa040680.42543751
160Renin-angiotensin system_Homo sapiens_hsa046140.40851289
161ErbB signaling pathway_Homo sapiens_hsa040120.40772785
162Glioma_Homo sapiens_hsa052140.39824306
163alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37719561
164Type II diabetes mellitus_Homo sapiens_hsa049300.33564539
165Prion diseases_Homo sapiens_hsa050200.33127290
166Glucagon signaling pathway_Homo sapiens_hsa049220.32283802
167Linoleic acid metabolism_Homo sapiens_hsa005910.29611426
168Antigen processing and presentation_Homo sapiens_hsa046120.28618621
169Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22485683
170Insulin signaling pathway_Homo sapiens_hsa049100.19771538
171AMPK signaling pathway_Homo sapiens_hsa041520.16766952
172Legionellosis_Homo sapiens_hsa051340.14898484
173Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14786071
174Bladder cancer_Homo sapiens_hsa052190.13498057
175Vitamin B6 metabolism_Homo sapiens_hsa007500.13422615
176Prolactin signaling pathway_Homo sapiens_hsa049170.12554493
177Insulin secretion_Homo sapiens_hsa049110.11035323
178Regulation of autophagy_Homo sapiens_hsa041400.09014579
179Glycerophospholipid metabolism_Homo sapiens_hsa005640.08487115
180Acute myeloid leukemia_Homo sapiens_hsa052210.07466148

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