TRABD2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)5.89341259
2negative regulation of cell killing (GO:0031342)5.69115482
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.69115482
4negative thymic T cell selection (GO:0045060)5.56416687
5activated T cell proliferation (GO:0050798)5.54629010
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.18408491
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.17791489
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16702356
9positive T cell selection (GO:0043368)4.98291798
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81969188
11positive regulation of gamma-delta T cell activation (GO:0046645)4.75368760
12antigen processing and presentation of endogenous antigen (GO:0019883)4.74347322
13cellular response to interleukin-15 (GO:0071350)4.70918421
14response to interleukin-15 (GO:0070672)4.66314741
15regulation of B cell receptor signaling pathway (GO:0050855)4.52957520
16interferon-gamma production (GO:0032609)4.37324912
17tolerance induction (GO:0002507)4.27295826
18regulation of gamma-delta T cell differentiation (GO:0045586)4.23892623
19T cell selection (GO:0045058)4.23106463
20regulation of regulatory T cell differentiation (GO:0045589)4.22638338
21positive thymic T cell selection (GO:0045059)4.11376780
22regulation of alpha-beta T cell proliferation (GO:0046640)4.04364475
23regulation of gamma-delta T cell activation (GO:0046643)3.91701649
24thymic T cell selection (GO:0045061)3.85436338
25negative regulation of T cell mediated immunity (GO:0002710)3.84949675
26positive regulation of granulocyte differentiation (GO:0030854)3.84474132
27positive regulation of alpha-beta T cell proliferation (GO:0046641)3.77974237
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.75091153
29positive regulation of T cell differentiation in thymus (GO:0033089)3.67265570
30alpha-beta T cell differentiation (GO:0046632)3.67189846
31regulation of isotype switching to IgG isotypes (GO:0048302)3.66482386
32negative regulation of cAMP-mediated signaling (GO:0043951)3.58555651
33regulation of T cell mediated cytotoxicity (GO:0001914)3.51770634
34DNA deamination (GO:0045006)3.48554302
35positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41196878
36leukocyte aggregation (GO:0070486)3.38462951
37alpha-beta T cell activation (GO:0046631)3.36810567
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31551862
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27456910
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.27202421
41negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24453882
42mast cell activation (GO:0045576)3.19666555
43mast cell activation involved in immune response (GO:0002279)3.12794052
44mast cell degranulation (GO:0043303)3.12794052
45regulation of natural killer cell mediated immunity (GO:0002715)3.06805452
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06805452
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.05980441
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05036420
49behavioral response to nicotine (GO:0035095)3.04739164
50T cell receptor signaling pathway (GO:0050852)3.03735196
51negative regulation of leukocyte mediated immunity (GO:0002704)2.97215878
52T cell differentiation (GO:0030217)2.96310783
53T cell migration (GO:0072678)2.93651561
54antigen receptor-mediated signaling pathway (GO:0050851)2.93491737
55regulation of T cell tolerance induction (GO:0002664)2.93071079
56negative regulation of adaptive immune response (GO:0002820)2.90820687
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85435214
58cAMP catabolic process (GO:0006198)2.84789852
59adaptation of signaling pathway (GO:0023058)2.84312413
60antigen processing and presentation via MHC class Ib (GO:0002475)2.83059913
61regulation of cell killing (GO:0031341)2.82601056
62regulation of B cell differentiation (GO:0045577)2.80001500
63regulation of MHC class I biosynthetic process (GO:0045343)2.77919881
64negative regulation of B cell mediated immunity (GO:0002713)2.77353085
65negative regulation of immunoglobulin mediated immune response (GO:0002890)2.77353085
66positive regulation of defense response to virus by host (GO:0002230)2.75319175
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74790690
68indolalkylamine metabolic process (GO:0006586)2.68757605
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.68653549
70regulation of alpha-beta T cell activation (GO:0046634)2.68341437
71positive regulation of DNA recombination (GO:0045911)2.67286976
72negative regulation of interleukin-1 production (GO:0032692)2.66601425
73B cell receptor signaling pathway (GO:0050853)2.66027287
74positive regulation of isotype switching (GO:0045830)2.65617363
75regulation of T cell receptor signaling pathway (GO:0050856)2.65487974
76positive regulation of alpha-beta T cell activation (GO:0046635)2.63727804
77regulation of granulocyte differentiation (GO:0030852)2.63336779
78positive regulation of cell killing (GO:0031343)2.61928757
79positive regulation of CREB transcription factor activity (GO:0032793)2.61926609
80neural tube formation (GO:0001841)2.61877642
81positive regulation of tolerance induction (GO:0002645)2.60905410
82pyrimidine ribonucleoside catabolic process (GO:0046133)2.58678321
83regulation of T cell mediated immunity (GO:0002709)2.57867993
84fucose catabolic process (GO:0019317)2.56396179
85L-fucose metabolic process (GO:0042354)2.56396179
86L-fucose catabolic process (GO:0042355)2.56396179
87negative regulation of interleukin-1 beta production (GO:0032691)2.56322502
88T cell activation (GO:0042110)2.55479846
89cytidine deamination (GO:0009972)2.52344216
90cytidine metabolic process (GO:0046087)2.52344216
91cytidine catabolic process (GO:0006216)2.52344216
92negative regulation of alpha-beta T cell activation (GO:0046636)2.49494982
93kidney morphogenesis (GO:0060993)2.48029848
94interferon-gamma secretion (GO:0072643)2.46952138
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46833470
96negative regulation of T-helper cell differentiation (GO:0045623)2.46833470
97regulation of tolerance induction (GO:0002643)2.46431777
98lymph node development (GO:0048535)2.46369873
99negative regulation of alpha-beta T cell differentiation (GO:0046639)2.46172882
100positive regulation of interleukin-2 production (GO:0032743)2.46132673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.32963566
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.82339539
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.64139135
4RUNX_20019798_ChIP-Seq_JUKART_Human3.31608669
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20423614
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16616740
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62504784
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.45955590
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.40029952
10ZNF274_21170338_ChIP-Seq_K562_Hela2.35498768
11MYB_26560356_Chip-Seq_TH2_Human2.28360362
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.15152306
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13081453
14GATA3_26560356_Chip-Seq_TH2_Human2.06654032
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04262217
16GATA3_27048872_Chip-Seq_THYMUS_Human1.91447213
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87988910
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74843040
19MYB_26560356_Chip-Seq_TH1_Human1.74295381
20VDR_22108803_ChIP-Seq_LS180_Human1.70757266
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67341324
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60357842
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54859356
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51938260
25ER_23166858_ChIP-Seq_MCF-7_Human1.50684671
26SCL_19346495_ChIP-Seq_HPC-7_Human1.46049657
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44733160
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44431950
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38120449
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.38009198
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37519378
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31908400
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29739976
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.28725882
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28013973
36BCAT_22108803_ChIP-Seq_LS180_Human1.27801256
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24388608
38IRF1_19129219_ChIP-ChIP_H3396_Human1.23704937
39SMRT_27268052_Chip-Seq_Bcells_Human1.23156732
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21820542
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20750462
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20452350
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20258813
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.19455817
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.18177119
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17482438
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17037427
48CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16533754
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15915635
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15478021
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15213922
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14754473
53VDR_23849224_ChIP-Seq_CD4+_Human1.14709173
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14707870
55GATA3_26560356_Chip-Seq_TH1_Human1.12331037
56SPI1_23547873_ChIP-Seq_NB4_Human1.11945806
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.11825696
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11535306
59STAT3_23295773_ChIP-Seq_U87_Human1.08568772
60UTX_26944678_Chip-Seq_JUKART_Human1.07851703
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.06734798
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.05968037
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05655012
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04460451
65RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04255493
66EWS_26573619_Chip-Seq_HEK293_Human1.03855431
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.03047650
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02890254
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.02042041
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02042041
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01510198
72MAF_26560356_Chip-Seq_TH1_Human1.00989567
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00897021
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00321420
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99247929
76TP53_22573176_ChIP-Seq_HFKS_Human0.98723567
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97472930
78FUS_26573619_Chip-Seq_HEK293_Human0.97349088
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96672707
80GBX2_23144817_ChIP-Seq_PC3_Human0.96599934
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.96364511
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95963765
83TCF4_23295773_ChIP-Seq_U87_Human0.95558556
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.95142138
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95139413
86IGF1R_20145208_ChIP-Seq_DFB_Human0.94551744
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94328603
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92696458
89MAF_26560356_Chip-Seq_TH2_Human0.92320803
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92268550
91AR_20517297_ChIP-Seq_VCAP_Human0.91802743
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91467477
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90358014
94VDR_24787735_ChIP-Seq_THP-1_Human0.90099381
95NANOG_20526341_ChIP-Seq_ESCs_Human0.88834713
96P300_19829295_ChIP-Seq_ESCs_Human0.88586802
97TCF4_22108803_ChIP-Seq_LS180_Human0.88429520
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88396876
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86531357
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85526756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.33964135
2MP0003724_increased_susceptibility_to3.41764423
3MP0005671_abnormal_response_to3.36474595
4MP0001800_abnormal_humoral_immune3.04141328
5MP0001835_abnormal_antigen_presentation2.84382502
6MP0002138_abnormal_hepatobiliary_system2.60855520
7MP0003866_abnormal_defecation2.40083572
8MP0003436_decreased_susceptibility_to2.33921319
9MP0001986_abnormal_taste_sensitivity2.31054056
10MP0002723_abnormal_immune_serum2.28882649
11MP0000685_abnormal_immune_system2.28779330
12MP0009333_abnormal_splenocyte_physiolog2.27660421
13MP0002420_abnormal_adaptive_immunity2.23784008
14MP0001819_abnormal_immune_cell2.21104779
15MP0001873_stomach_inflammation2.20563480
16MP0001790_abnormal_immune_system2.16641247
17MP0005387_immune_system_phenotype2.16641247
18MP0003787_abnormal_imprinting2.11918030
19MP0005000_abnormal_immune_tolerance2.10671954
20MP0002452_abnormal_antigen_presenting2.05503499
21MP0008877_abnormal_DNA_methylation1.93242541
22MP0000703_abnormal_thymus_morphology1.89946810
23MP0004381_abnormal_hair_follicle1.84847461
24MP0002398_abnormal_bone_marrow1.83023744
25MP0010155_abnormal_intestine_physiology1.80427739
26MP0005025_abnormal_response_to1.78734760
27MP0000716_abnormal_immune_system1.78454791
28MP0005075_abnormal_melanosome_morpholog1.77023924
29MP0003646_muscle_fatigue1.76739316
30MP0004130_abnormal_muscle_cell1.75081873
31MP0005310_abnormal_salivary_gland1.74776119
32MP0000689_abnormal_spleen_morphology1.71112016
33MP0009785_altered_susceptibility_to1.68168393
34MP0002405_respiratory_system_inflammati1.61577438
35MP0002277_abnormal_respiratory_mucosa1.55954800
36MP0002148_abnormal_hypersensitivity_rea1.54748212
37MP0002419_abnormal_innate_immunity1.54426165
38MP0000569_abnormal_digit_pigmentation1.49819858
39MP0002722_abnormal_immune_system1.48927682
40MP0008872_abnormal_physiological_respon1.42809319
41MP0003195_calcinosis1.42809063
42MP0002396_abnormal_hematopoietic_system1.37931085
43MP0004147_increased_porphyrin_level1.35326490
44MP0008057_abnormal_DNA_replication1.34103922
45MP0002429_abnormal_blood_cell1.33151868
46MP0000427_abnormal_hair_cycle1.31399595
47MP0001845_abnormal_inflammatory_respons1.30937639
48MP0002876_abnormal_thyroid_physiology1.30322935
49MP0001663_abnormal_digestive_system1.29619912
50MP0005085_abnormal_gallbladder_physiolo1.27868558
51MP0004142_abnormal_muscle_tone1.26173708
52MP0005174_abnormal_tail_pigmentation1.23528930
53MP0002009_preneoplasia1.23187378
54MP0005551_abnormal_eye_electrophysiolog1.21946778
55MP0002928_abnormal_bile_duct1.20136044
56MP0005389_reproductive_system_phenotype1.16133755
57MP0002102_abnormal_ear_morphology1.15865375
58MP0006292_abnormal_olfactory_placode1.15751657
59MP0001851_eye_inflammation1.10258881
60MP0003252_abnormal_bile_duct1.09780593
61MP0001919_abnormal_reproductive_system1.06873659
62MP0000015_abnormal_ear_pigmentation1.03891524
63MP0004043_abnormal_pH_regulation1.03633085
64MP0006082_CNS_inflammation1.02374842
65MP0005360_urolithiasis1.00566573
66MP0001533_abnormal_skeleton_physiology1.00483607
67MP0002163_abnormal_gland_morphology0.99532873
68MP0001501_abnormal_sleep_pattern0.98057720
69MP0002166_altered_tumor_susceptibility0.97989121
70MP0002933_joint_inflammation0.96160551
71MP0008875_abnormal_xenobiotic_pharmacok0.95684824
72MP0008961_abnormal_basal_metabolism0.95669799
73MP0000470_abnormal_stomach_morphology0.94948137
74MP0004947_skin_inflammation0.93954111
75MP0000490_abnormal_crypts_of0.93718104
76MP0001968_abnormal_touch/_nociception0.92338023
77MP0001764_abnormal_homeostasis0.91253510
78MP0001348_abnormal_lacrimal_gland0.90987176
79MP0002132_abnormal_respiratory_system0.90596291
80MP0002837_dystrophic_cardiac_calcinosis0.90412208
81MP0001485_abnormal_pinna_reflex0.87705663
82MP0001765_abnormal_ion_homeostasis0.87624572
83MP0009764_decreased_sensitivity_to0.85751353
84MP0003300_gastrointestinal_ulcer0.84463132
85MP0003786_premature_aging0.82631676
86MP0008469_abnormal_protein_level0.81659339
87MP0000465_gastrointestinal_hemorrhage0.80696722
88MP0002693_abnormal_pancreas_physiology0.80289059
89MP0010329_abnormal_lipoprotein_level0.78592857
90MP0003045_fibrosis0.75286579
91MP0000230_abnormal_systemic_arterial0.73792725
92MP0002160_abnormal_reproductive_system0.72808717
93MP0005381_digestive/alimentary_phenotyp0.71016338
94MP0005365_abnormal_bile_salt0.70871005
95MP0008995_early_reproductive_senescence0.67607699
96MP0008058_abnormal_DNA_repair0.66115261
97MP0002006_tumorigenesis0.60223474
98MP0005266_abnormal_metabolism0.60031072
99MP0002136_abnormal_kidney_physiology0.59352968
100MP0005376_homeostasis/metabolism_phenot0.59001461

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.70735192
2T lymphocytopenia (HP:0005403)4.41560781
3Elevated erythrocyte sedimentation rate (HP:0003565)4.31587395
4Abnormality of T cell number (HP:0011839)4.30259066
5Pustule (HP:0200039)3.88258735
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.79947148
7Congenital stationary night blindness (HP:0007642)3.58864951
8Abnormality of T cells (HP:0002843)3.55929943
9Pancreatic cysts (HP:0001737)3.49121439
10Panhypogammaglobulinemia (HP:0003139)3.44485456
11IgG deficiency (HP:0004315)3.32573749
12Severe combined immunodeficiency (HP:0004430)3.25609516
13Recurrent fungal infections (HP:0002841)3.24630432
14Myositis (HP:0100614)3.15830370
15Pancreatic fibrosis (HP:0100732)2.91328094
16Recurrent cutaneous fungal infections (HP:0011370)2.87298668
17Chronic mucocutaneous candidiasis (HP:0002728)2.87298668
18Retrobulbar optic neuritis (HP:0100654)2.85777126
19Optic neuritis (HP:0100653)2.85777126
20Stomach cancer (HP:0012126)2.85468455
21Genetic anticipation (HP:0003743)2.82654005
22Eczematoid dermatitis (HP:0000976)2.79095996
23Abnormality of the renal cortex (HP:0011035)2.76166484
24Abnormality of T cell physiology (HP:0011840)2.73988487
25Molar tooth sign on MRI (HP:0002419)2.71493711
26Abnormality of midbrain morphology (HP:0002418)2.71493711
27Encephalitis (HP:0002383)2.69180936
28Hypochromic microcytic anemia (HP:0004840)2.67162717
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63986363
30Decreased circulating renin level (HP:0003351)2.62832671
31Abnormality of eosinophils (HP:0001879)2.62353187
32Orchitis (HP:0100796)2.60334814
33True hermaphroditism (HP:0010459)2.58845878
34Recurrent bacterial skin infections (HP:0005406)2.58666617
35Thyroiditis (HP:0100646)2.55647686
36Abnormal rod and cone electroretinograms (HP:0008323)2.54088265
37Hypochromic anemia (HP:0001931)2.46062306
38Attenuation of retinal blood vessels (HP:0007843)2.40193706
39Progressive cerebellar ataxia (HP:0002073)2.34561746
40Recurrent abscess formation (HP:0002722)2.31475032
41Leukocytosis (HP:0001974)2.29312700
42Hypoplasia of the thymus (HP:0000778)2.27787379
43Gastrointestinal infarctions (HP:0005244)2.26730053
44Pendular nystagmus (HP:0012043)2.22343506
45Metabolic alkalosis (HP:0200114)2.19595982
46Abnormality of DNA repair (HP:0003254)2.19547573
47Chronic hepatic failure (HP:0100626)2.18762763
48Eosinophilia (HP:0001880)2.16310141
49Congenital sensorineural hearing impairment (HP:0008527)2.15923117
50Recurrent skin infections (HP:0001581)2.15512819
51Combined immunodeficiency (HP:0005387)2.14934838
52Chronic diarrhea (HP:0002028)2.14766883
53Clumsiness (HP:0002312)2.14141641
54Hyperventilation (HP:0002883)2.13774300
55Cystic liver disease (HP:0006706)2.13401675
56Nephronophthisis (HP:0000090)2.11383487
57Renal cortical cysts (HP:0000803)2.09176398
58Alkalosis (HP:0001948)2.09123730
59Lymphopenia (HP:0001888)2.06027981
60Abnormality of the renal medulla (HP:0100957)2.05472688
61Autoimmune hemolytic anemia (HP:0001890)2.04758607
62Abnormality of the renal collecting system (HP:0004742)2.03689309
63Vasculitis (HP:0002633)2.03499360
64Papilledema (HP:0001085)2.03109563
65Meningitis (HP:0001287)2.01093933
66Hemoptysis (HP:0002105)2.00254924
67Recurrent viral infections (HP:0004429)1.98637862
68IgM deficiency (HP:0002850)1.98412707
69Oligodactyly (hands) (HP:0001180)1.97643171
70Pulmonary infiltrates (HP:0002113)1.97404828
71Mediastinal lymphadenopathy (HP:0100721)1.95878163
72Granulocytopenia (HP:0001913)1.95367956
73Alveolar cell carcinoma (HP:0006519)1.95208615
74Fair hair (HP:0002286)1.94248488
75Abnormality of the nasal septum (HP:0000419)1.92608223
76Keratoconjunctivitis (HP:0001096)1.92419135
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.91772488
78Abnormality of alanine metabolism (HP:0010916)1.91473176
79Hyperalaninemia (HP:0003348)1.91473176
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91473176
81Asplenia (HP:0001746)1.91395559
82Abolished electroretinogram (ERG) (HP:0000550)1.91348127
83Recurrent bronchitis (HP:0002837)1.90085805
84Abnormality of cells of the lymphoid lineage (HP:0012140)1.89021989
85Bile duct proliferation (HP:0001408)1.88996216
86Abnormal biliary tract physiology (HP:0012439)1.88996216
87Congenital, generalized hypertrichosis (HP:0004540)1.88125936
88Hematochezia (HP:0002573)1.88024318
89Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86370473
90Neoplasm of the tracheobronchial system (HP:0100552)1.85795326
91Spontaneous hematomas (HP:0007420)1.84858235
92Gaze-evoked nystagmus (HP:0000640)1.82960855
93Inflammation of the large intestine (HP:0002037)1.79806416
94Abnormality of renin-angiotensin system (HP:0000847)1.77722425
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77475024
96Severe visual impairment (HP:0001141)1.76804903
97Cheilitis (HP:0100825)1.75639694
98Abnormality of B cell number (HP:0010975)1.75355821
99Keratoconjunctivitis sicca (HP:0001097)1.74046932
100Progressive inability to walk (HP:0002505)1.72545727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.38440233
2FRK4.55280506
3MAP4K14.16922344
4ACVR1B3.78485394
5TAOK32.85947049
6CAMKK22.85118392
7BMPR1B2.69015887
8ITK2.28497564
9GRK62.06548994
10NLK1.94551804
11TEC1.86867038
12ADRBK21.77696925
13RIPK41.65995214
14BTK1.58556208
15FES1.56697242
16TNK21.52916265
17SYK1.48522908
18TYK21.45782379
19WNK41.45579086
20IKBKE1.41627202
21LCK1.39875097
22NUAK11.38467094
23ZAP701.34158014
24CSK1.32864314
25GRK11.26359588
26CAMKK11.24225800
27HCK1.24203851
28OXSR11.23296792
29STK391.21048316
30MARK31.20137127
31JAK31.18645206
32TLK11.17633057
33PRKCQ1.13607530
34IKBKB1.11845221
35BLK1.10493387
36TGFBR11.08938338
37JAK11.08485523
38LYN1.07693695
39IRAK41.06784671
40ADRBK11.05984404
41SIK21.04805876
42ZAK0.88381194
43MAPK130.88095355
44PIM10.87823937
45MELK0.87082890
46GRK70.86982089
47GRK50.85778664
48STK100.84960100
49MAP2K20.84943344
50PTK2B0.82960450
51STK110.80826177
52PASK0.80068817
53PIK3CA0.79458671
54PDK10.78455278
55MAP4K20.77103293
56PDK20.74346719
57EPHB10.74109587
58STK380.73087084
59MAP3K70.72820642
60PRPF4B0.71693536
61INSRR0.70744548
62PIK3CG0.65903716
63HIPK20.63324533
64TGFBR20.62270960
65JAK20.59996129
66SIK30.57253661
67MAP2K60.56881441
68MAP3K140.56177423
69MAPK110.55917017
70PINK10.53858234
71SGK20.53127948
72WNK30.52831971
73CAMK40.51820813
74PRKCH0.50654334
75CSF1R0.49943694
76IRAK10.49507054
77RPS6KA60.49088590
78KIT0.47855732
79DAPK20.46610400
80TNIK0.45573789
81WNK10.44814670
82PAK30.43115080
83YES10.42806888
84FGFR30.42621963
85PRKD20.41479921
86TYRO30.41034680
87CASK0.40970652
88CAMK10.39312220
89FGFR20.38289399
90BMPR20.37089219
91MAPK120.36883819
92CHUK0.34456960
93MAP2K30.33451210
94MAP3K130.33133307
95MST40.31323409
96PRKAA20.30809596
97FYN0.30520261
98CDK40.30046818
99MAP3K100.29589917
100IGF1R0.28408647

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.12392609
2Graft-versus-host disease_Homo sapiens_hsa053322.70569495
3Allograft rejection_Homo sapiens_hsa053302.52744623
4Autoimmune thyroid disease_Homo sapiens_hsa053202.51501901
5Nitrogen metabolism_Homo sapiens_hsa009102.45669618
6T cell receptor signaling pathway_Homo sapiens_hsa046602.42638605
7Linoleic acid metabolism_Homo sapiens_hsa005912.40372679
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34608378
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.25378193
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18959651
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92407920
12Hematopoietic cell lineage_Homo sapiens_hsa046401.82809309
13Type I diabetes mellitus_Homo sapiens_hsa049401.82055804
14Phototransduction_Homo sapiens_hsa047441.72257783
15Caffeine metabolism_Homo sapiens_hsa002321.69181604
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.62289075
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60861929
18Antigen processing and presentation_Homo sapiens_hsa046121.57769842
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49674502
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47975304
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47442252
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.41708647
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39184794
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36999532
25Measles_Homo sapiens_hsa051621.36304587
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32006092
27Glycerolipid metabolism_Homo sapiens_hsa005611.25306655
28Osteoclast differentiation_Homo sapiens_hsa043801.23158761
29Ether lipid metabolism_Homo sapiens_hsa005651.21561652
30Dorso-ventral axis formation_Homo sapiens_hsa043201.20144371
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17985681
32B cell receptor signaling pathway_Homo sapiens_hsa046621.13185802
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12519768
34Asthma_Homo sapiens_hsa053101.04636752
35Morphine addiction_Homo sapiens_hsa050321.04383413
36Homologous recombination_Homo sapiens_hsa034401.02308853
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02082075
38ABC transporters_Homo sapiens_hsa020101.01827572
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.01659703
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99333622
41Chemokine signaling pathway_Homo sapiens_hsa040620.98802663
42Leishmaniasis_Homo sapiens_hsa051400.98075365
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96108697
44Arachidonic acid metabolism_Homo sapiens_hsa005900.95020984
45Regulation of autophagy_Homo sapiens_hsa041400.93400724
46Retinol metabolism_Homo sapiens_hsa008300.91547097
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91498146
48Chemical carcinogenesis_Homo sapiens_hsa052040.89491852
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88264588
50Tryptophan metabolism_Homo sapiens_hsa003800.87010112
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.85204253
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84588459
53Viral myocarditis_Homo sapiens_hsa054160.82645868
54Staphylococcus aureus infection_Homo sapiens_hsa051500.82074356
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79136134
56Ovarian steroidogenesis_Homo sapiens_hsa049130.77907828
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76875360
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.74966178
59Herpes simplex infection_Homo sapiens_hsa051680.71984514
60Sulfur metabolism_Homo sapiens_hsa009200.71765152
61African trypanosomiasis_Homo sapiens_hsa051430.71539256
62Fanconi anemia pathway_Homo sapiens_hsa034600.67132339
63Fat digestion and absorption_Homo sapiens_hsa049750.66794497
64Platelet activation_Homo sapiens_hsa046110.66671736
65RNA polymerase_Homo sapiens_hsa030200.66149568
66Tuberculosis_Homo sapiens_hsa051520.66148019
67FoxO signaling pathway_Homo sapiens_hsa040680.61864711
68Butanoate metabolism_Homo sapiens_hsa006500.60739727
69Sulfur relay system_Homo sapiens_hsa041220.60361788
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59824068
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59666799
72Selenocompound metabolism_Homo sapiens_hsa004500.59538304
73RNA degradation_Homo sapiens_hsa030180.59478514
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58826093
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58473635
76TNF signaling pathway_Homo sapiens_hsa046680.57124307
77Olfactory transduction_Homo sapiens_hsa047400.57092821
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52421600
79Toxoplasmosis_Homo sapiens_hsa051450.49855565
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48298357
81Serotonergic synapse_Homo sapiens_hsa047260.48128983
82Basal transcription factors_Homo sapiens_hsa030220.47255506
83Peroxisome_Homo sapiens_hsa041460.47157234
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.46837350
85Vitamin digestion and absorption_Homo sapiens_hsa049770.46590940
86Taste transduction_Homo sapiens_hsa047420.46500342
87Acute myeloid leukemia_Homo sapiens_hsa052210.45809088
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44629351
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44370095
90Ribosome_Homo sapiens_hsa030100.43482033
91Non-homologous end-joining_Homo sapiens_hsa034500.42424079
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41590192
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.40494635
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.38518151
95Cholinergic synapse_Homo sapiens_hsa047250.38466430
96Calcium signaling pathway_Homo sapiens_hsa040200.38042932
97Influenza A_Homo sapiens_hsa051640.36689937
98MAPK signaling pathway_Homo sapiens_hsa040100.35935073
99Non-small cell lung cancer_Homo sapiens_hsa052230.34195967
100Choline metabolism in cancer_Homo sapiens_hsa052310.33371172

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