TRABD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.58115143
2sarcomere organization (GO:0045214)5.33984451
3myofibril assembly (GO:0030239)4.83463339
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.37276025
5regulation of actin filament-based movement (GO:1903115)4.35670220
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.24785903
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.21009498
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.15282114
9notochord development (GO:0030903)4.12073220
10regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.96132344
11ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.95703265
12cardiac muscle tissue morphogenesis (GO:0055008)3.94802678
13regulation of relaxation of muscle (GO:1901077)3.94435396
14cardiac muscle contraction (GO:0060048)3.90235775
15tricarboxylic acid cycle (GO:0006099)3.89954642
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.89491222
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.88398276
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.78720235
19cardiac muscle cell development (GO:0055013)3.76012445
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.73580623
21atrioventricular valve morphogenesis (GO:0003181)3.72373700
22glomerular basement membrane development (GO:0032836)3.72301375
23serine family amino acid catabolic process (GO:0009071)3.71705702
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71358812
25muscle filament sliding (GO:0030049)3.68477698
26actin-myosin filament sliding (GO:0033275)3.68477698
27branching involved in salivary gland morphogenesis (GO:0060445)3.66971450
28ventricular cardiac muscle cell action potential (GO:0086005)3.65976368
29adult heart development (GO:0007512)3.59943260
30cardiac cell development (GO:0055006)3.59794968
31muscle tissue morphogenesis (GO:0060415)3.58684801
32negative regulation of protein localization to cell surface (GO:2000009)3.58115097
33heart trabecula formation (GO:0060347)3.57588287
34regulation of cardiac muscle cell contraction (GO:0086004)3.56741580
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51680597
36endothelial cell chemotaxis (GO:0035767)3.51180355
37plasma membrane repair (GO:0001778)3.50519149
38creatine metabolic process (GO:0006600)3.48663907
39actomyosin structure organization (GO:0031032)3.47676332
40carnitine shuttle (GO:0006853)3.43248883
41desmosome organization (GO:0002934)3.42975173
42positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.38389303
43actin-mediated cell contraction (GO:0070252)3.38262176
44regulation of cardioblast differentiation (GO:0051890)3.37281602
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.36019033
46omega-hydroxylase P450 pathway (GO:0097267)3.35987443
47regulation of cell communication by electrical coupling (GO:0010649)3.34469252
48regulation of skeletal muscle contraction (GO:0014819)3.34126359
49cardiac muscle hypertrophy (GO:0003300)3.33704923
50G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.32769057
51paraxial mesoderm development (GO:0048339)3.32003585
52axon extension involved in axon guidance (GO:0048846)3.30455603
53neuron projection extension involved in neuron projection guidance (GO:1902284)3.30455603
54midgut development (GO:0007494)3.30405950
55regulation of striated muscle contraction (GO:0006942)3.29585371
56quaternary ammonium group transport (GO:0015697)3.28226405
57striated muscle hypertrophy (GO:0014897)3.28017133
58regulation of apoptotic process involved in morphogenesis (GO:1902337)3.27359114
59carnitine transport (GO:0015879)3.26219020
60amino-acid betaine transport (GO:0015838)3.26219020
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.25270257
62regulation of sequestering of triglyceride (GO:0010889)3.25233886
63regulation of sarcomere organization (GO:0060297)3.24572318
64respiratory electron transport chain (GO:0022904)3.24411530
65glyoxylate metabolic process (GO:0046487)3.21598243
66response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.17394005
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17015319
68regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.16412132
69fatty acid beta-oxidation (GO:0006635)3.14305647
70epoxygenase P450 pathway (GO:0019373)3.13516013
71aminoglycoside antibiotic metabolic process (GO:0030647)3.12870890
72electron transport chain (GO:0022900)3.12807756
73metanephric tubule development (GO:0072170)3.12503435
74metanephric nephron tubule development (GO:0072234)3.12503435
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08782808
76prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.07337755
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.07174162
78glycine metabolic process (GO:0006544)3.06978604
79regulation of cardiac muscle contraction (GO:0055117)3.06944460
80regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.06804178
81outer ear morphogenesis (GO:0042473)3.06173315
82regulation of the force of heart contraction (GO:0002026)3.03413256
83collecting duct development (GO:0072044)3.01873641
84metanephric epithelium development (GO:0072207)3.00778231
85cellular response to epinephrine stimulus (GO:0071872)2.99272776
86branched-chain amino acid catabolic process (GO:0009083)2.98383240
87response to epinephrine (GO:0071871)2.97929667
88fatty acid transmembrane transport (GO:1902001)2.97651263
89cell communication involved in cardiac conduction (GO:0086065)2.96177092
90branched-chain amino acid metabolic process (GO:0009081)2.95900435
91regulation of stem cell maintenance (GO:2000036)2.94954388
92positive regulation of p38MAPK cascade (GO:1900745)2.94672256
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.94421426
94ATP synthesis coupled proton transport (GO:0015986)2.94266977
95energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94266977
96short-term memory (GO:0007614)2.94007186
97metanephric nephron epithelium development (GO:0072243)2.91887164
98carnitine transmembrane transport (GO:1902603)2.90395266
99glomerular filtration (GO:0003094)2.89586846
100L-ascorbic acid metabolic process (GO:0019852)2.89124590
101cell migration involved in gastrulation (GO:0042074)2.88722612
102anterior/posterior axis specification, embryo (GO:0008595)2.87223644
103aspartate family amino acid catabolic process (GO:0009068)2.87125014
104muscle hypertrophy (GO:0014896)2.86436815
105trabecula formation (GO:0060343)2.86172322
106negative regulation of catenin import into nucleus (GO:0035414)2.85372270
107regulation of membrane repolarization (GO:0060306)2.84608876
108hemidesmosome assembly (GO:0031581)2.84507413
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83416973
110peptidyl-glutamic acid carboxylation (GO:0017187)2.81492501
111protein carboxylation (GO:0018214)2.81492501
112L-phenylalanine catabolic process (GO:0006559)2.80694253
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.80694253
114striated muscle contraction (GO:0006941)2.79709303
115positive regulation of mesonephros development (GO:0061213)2.78579582
116relaxation of cardiac muscle (GO:0055119)2.77548314
117exogenous drug catabolic process (GO:0042738)2.76975820
118regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.75275293
119lung-associated mesenchyme development (GO:0060484)2.75263205
120pattern specification involved in kidney development (GO:0061004)2.73581687
121regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72155007
122sarcoplasmic reticulum calcium ion transport (GO:0070296)2.71448300
123drug catabolic process (GO:0042737)2.71425050
124positive regulation of SMAD protein import into nucleus (GO:0060391)2.71375673
125regulation of protein activation cascade (GO:2000257)2.68836440
126regulation of mesonephros development (GO:0061217)2.68809227
127L-serine metabolic process (GO:0006563)2.68458248
128mesenchymal cell proliferation (GO:0010463)2.68424017
129primitive streak formation (GO:0090009)2.67790998
1304-hydroxyproline metabolic process (GO:0019471)2.67123945
131central nervous system myelination (GO:0022010)2.67054827
132axon ensheathment in central nervous system (GO:0032291)2.67054827
133regulation of coenzyme metabolic process (GO:0051196)2.65325102
134regulation of cofactor metabolic process (GO:0051193)2.65325102
135cell differentiation involved in metanephros development (GO:0072202)2.64526222
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64171044
137lysine catabolic process (GO:0006554)2.63861069
138lysine metabolic process (GO:0006553)2.63861069
139atrial septum morphogenesis (GO:0060413)2.62953201
140glomerular visceral epithelial cell development (GO:0072015)2.62888253
1412-oxoglutarate metabolic process (GO:0006103)2.61300494
142short-chain fatty acid metabolic process (GO:0046459)2.61227863
143regulation of complement activation (GO:0030449)2.60590482
144convergent extension (GO:0060026)2.59627108
145positive regulation of metanephros development (GO:0072216)2.58765324
146nephron tubule development (GO:0072080)2.58761344
147embryonic camera-type eye development (GO:0031076)2.58701536
148renal filtration (GO:0097205)2.58562136
149mesenchymal to epithelial transition (GO:0060231)2.58471342
150response to mercury ion (GO:0046689)2.58462907
151embryonic skeletal joint morphogenesis (GO:0060272)2.58049451
152biotin metabolic process (GO:0006768)2.57718379
153negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57069064
154actin filament-based movement (GO:0030048)2.55978879
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.55651212
156embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55315147
157positive regulation of glomerulus development (GO:0090193)2.55305868
158nephron epithelium development (GO:0072009)2.55179469
159regulation of glomerulus development (GO:0090192)2.54801863
160cardiac muscle cell action potential (GO:0086001)2.52973041
161regulation of p38MAPK cascade (GO:1900744)2.52531835
162SMAD protein signal transduction (GO:0060395)2.52436433
163NADH metabolic process (GO:0006734)2.52273914
164fatty acid oxidation (GO:0019395)2.51749215
165ethanol oxidation (GO:0006069)2.51624501
166non-canonical Wnt signaling pathway (GO:0035567)2.51614250
167metanephric mesenchyme development (GO:0072075)2.51358985
168cardiac muscle hypertrophy in response to stress (GO:0014898)2.51350767
169muscle hypertrophy in response to stress (GO:0003299)2.51350767
170cardiac muscle adaptation (GO:0014887)2.51350767
171organ induction (GO:0001759)2.50225475
172mesonephros development (GO:0001823)2.50120130
173mesenchymal cell differentiation (GO:0048762)2.47240845
174mesenchymal cell differentiation involved in kidney development (GO:0072161)2.47030663
175mesenchymal cell differentiation involved in renal system development (GO:2001012)2.47030663
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46467485
177L-phenylalanine metabolic process (GO:0006558)2.46467485
178outflow tract septum morphogenesis (GO:0003148)2.46028632
179cellular glucuronidation (GO:0052695)2.44959801
180Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43742721
181regulation of mesoderm development (GO:2000380)2.40961871
182regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.39425787
183urea metabolic process (GO:0019627)2.37921191
184blood coagulation, intrinsic pathway (GO:0007597)2.37781836
185lateral sprouting from an epithelium (GO:0060601)2.35834846
186regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33592429
187glucuronate metabolic process (GO:0019585)2.33574364
188uronic acid metabolic process (GO:0006063)2.33574364
189complement activation, alternative pathway (GO:0006957)2.32293429
190regulation of catenin import into nucleus (GO:0035412)2.31174046
191axis elongation (GO:0003401)2.31018763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.32992248
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.31855489
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27918057
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.18991353
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59249220
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51191524
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51191524
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51191524
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41067930
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36397871
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34549658
12EZH2_22144423_ChIP-Seq_EOC_Human2.28427401
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25978804
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23950478
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23950478
16GBX2_23144817_ChIP-Seq_PC3_Human2.23851464
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.22282482
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13247973
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12265200
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.09957914
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08764486
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95369925
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92686251
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89356208
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.86763850
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.86763850
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86643313
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82928742
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80557345
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.75795111
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.73911878
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72817222
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71140709
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68717698
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.67431271
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67100342
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.66379378
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.64983078
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63503119
40AR_21572438_ChIP-Seq_LNCaP_Human1.63408915
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61240777
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.58640562
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57852278
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57492724
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.55045164
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.54599719
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52548367
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50690329
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.50404830
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.50316753
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49521546
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47799245
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45933824
54CJUN_26792858_Chip-Seq_BT549_Human1.45672332
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45165900
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.44341748
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43620122
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41538686
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40108895
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40108895
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.39517260
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38286207
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36427689
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34774187
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.34524565
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33950170
67CTCF_27219007_Chip-Seq_Bcells_Human1.33791297
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33226814
69MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30204558
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.28408676
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27032461
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25980718
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25071360
74TP53_18474530_ChIP-ChIP_U2OS_Human1.25012404
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21937534
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21594229
77AHR_22903824_ChIP-Seq_MCF-7_Human1.20247860
78DROSHA_22980978_ChIP-Seq_HELA_Human1.20035049
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.20031755
80VDR_22108803_ChIP-Seq_LS180_Human1.19975010
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19926126
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18476569
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18100110
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.17631227
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17199545
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16518679
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16368436
88KDM2B_26808549_Chip-Seq_K562_Human1.15571184
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14940580
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.13656385
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12994354
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12912197
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12443522
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.11617017
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09504186
96POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09092213
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08607877
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07899412
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07836810
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.07184169
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06797721
102TP53_16413492_ChIP-PET_HCT116_Human1.06071376
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05250177
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05125594
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04605396
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04426915
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.04171219
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04026794
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03844108
110TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02235200
111SMAD4_21799915_ChIP-Seq_A2780_Human1.01680806
112TAF15_26573619_Chip-Seq_HEK293_Human1.01375013
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01355778
114AR_21909140_ChIP-Seq_LNCAP_Human1.00965168
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00741030
116BCAT_22108803_ChIP-Seq_LS180_Human1.00491049
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00144149
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99193281
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98866210
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98724260
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.97796880
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.97337496
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96811823
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96516002
125CLOCK_20551151_ChIP-Seq_293T_Human0.94615515
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94028973
127RACK7_27058665_Chip-Seq_MCF-7_Human0.93973005
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.93764093
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92793339
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92782062
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92741300
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92666060
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92011869
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.91798753
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90709238
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90284243
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89600068
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89300871
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.89057738
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88469337
141ER_23166858_ChIP-Seq_MCF-7_Human0.87757938
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86195020
143P300_19829295_ChIP-Seq_ESCs_Human0.85796842
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85485882
145RNF2_27304074_Chip-Seq_NSC_Mouse0.85091099
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84998548
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84884161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.13788404
2MP0004084_abnormal_cardiac_muscle4.09423533
3MP0010030_abnormal_orbit_morphology3.93347735
4MP0000751_myopathy3.92900680
5MP0003646_muscle_fatigue3.73576556
6MP0004215_abnormal_myocardial_fiber3.71594705
7MP0005330_cardiomyopathy3.07336263
8MP0003283_abnormal_digestive_organ3.03148252
9MP0004036_abnormal_muscle_relaxation3.02057986
10MP0000749_muscle_degeneration2.83335984
11MP0008438_abnormal_cutaneous_collagen2.83143977
12MP0002138_abnormal_hepatobiliary_system2.60875133
13MP0005503_abnormal_tendon_morphology2.59485968
14MP0002972_abnormal_cardiac_muscle2.54926519
15MP0008775_abnormal_heart_ventricle2.53858833
16MP0004484_altered_response_of2.40349967
17MP0009053_abnormal_anal_canal2.38378553
18MP0003137_abnormal_impulse_conducting2.38360029
19MP0002139_abnormal_hepatobiliary_system2.37363894
20MP0005360_urolithiasis2.34531202
21MP0003890_abnormal_embryonic-extraembry2.31547397
22MP0005275_abnormal_skin_tensile2.25543812
23MP0006138_congestive_heart_failure2.24287137
24MP0005620_abnormal_muscle_contractility2.22315201
25MP0004087_abnormal_muscle_fiber2.10037815
26MP0004043_abnormal_pH_regulation2.09883840
27MP0003828_pulmonary_edema2.08485105
28MP0005385_cardiovascular_system_phenoty2.06723422
29MP0001544_abnormal_cardiovascular_syste2.06723422
30MP0004272_abnormal_basement_membrane2.05614012
31MP0003950_abnormal_plasma_membrane2.04316426
32MP0004130_abnormal_muscle_cell2.01676061
33MP0000750_abnormal_muscle_regeneration2.01133965
34MP0003937_abnormal_limbs/digits/tail_de1.89294062
35MP0001958_emphysema1.88836254
36MP0003942_abnormal_urinary_system1.84340849
37MP0005666_abnormal_adipose_tissue1.81573172
38MP0000537_abnormal_urethra_morphology1.81009955
39MP0010630_abnormal_cardiac_muscle1.77842416
40MP0005670_abnormal_white_adipose1.77451955
41MP0002108_abnormal_muscle_morphology1.66267487
42MP0004085_abnormal_heartbeat1.62966973
43MP0002106_abnormal_muscle_physiology1.59727675
44MP0005369_muscle_phenotype1.59205439
45MP0002697_abnormal_eye_size1.58275217
46MP0003119_abnormal_digestive_system1.55603600
47MP0010368_abnormal_lymphatic_system1.55434711
48MP0002233_abnormal_nose_morphology1.55072760
49MP0005623_abnormal_meninges_morphology1.54778682
50MP0005257_abnormal_intraocular_pressure1.52288616
51MP0003279_aneurysm1.51303552
52MP0004858_abnormal_nervous_system1.50912701
53MP0004133_heterotaxia1.49501166
54MP0004145_abnormal_muscle_electrophysio1.49343405
55MP0009384_cardiac_valve_regurgitation1.48283577
56MP0003938_abnormal_ear_development1.43465478
57MP0000759_abnormal_skeletal_muscle1.39712285
58MP0005375_adipose_tissue_phenotype1.38694685
59MP0000747_muscle_weakness1.37574459
60MP0000428_abnormal_craniofacial_morphol1.36207721
61MP0002932_abnormal_joint_morphology1.34813902
62MP0004185_abnormal_adipocyte_glucose1.26873974
63MP0002269_muscular_atrophy1.26142116
64MP0001879_abnormal_lymphatic_vessel1.24108157
65MP0002111_abnormal_tail_morphology1.20168966
66MP0003221_abnormal_cardiomyocyte_apopto1.19673499
67MP0000762_abnormal_tongue_morphology1.19527771
68MP0009250_abnormal_appendicular_skeleto1.18159761
69MP0008875_abnormal_xenobiotic_pharmacok1.15347634
70MP0001849_ear_inflammation1.15259149
71MP0000230_abnormal_systemic_arterial1.14949099
72MP0005187_abnormal_penis_morphology1.12672344
73MP0002092_abnormal_eye_morphology1.12436695
74MP0000343_altered_response_to1.12015224
75MP0002249_abnormal_larynx_morphology1.09850661
76MP0000566_synostosis1.09031026
77MP0003195_calcinosis1.08996751
78MP0001286_abnormal_eye_development1.06173384
79MP0005165_increased_susceptibility_to1.04582607
80MP0002127_abnormal_cardiovascular_syste1.03264891
81MP0000462_abnormal_digestive_system1.01812442
82MP0000678_abnormal_parathyroid_gland1.01410651
83MP0000013_abnormal_adipose_tissue1.01192510
84MP0002116_abnormal_craniofacial_bone1.00366142
85MP0003567_abnormal_fetal_cardiomyocyte0.99125872
86MP0005451_abnormal_body_composition0.98772025
87MP0004233_abnormal_muscle_weight0.97623184
88MP0006036_abnormal_mitochondrial_physio0.97211422
89MP0000003_abnormal_adipose_tissue0.97031604
90MP0001293_anophthalmia0.96674831
91MP0005076_abnormal_cell_differentiation0.95746323
92MP0002295_abnormal_pulmonary_circulatio0.95738581
93MP0005332_abnormal_amino_acid0.95279188
94MP0006292_abnormal_olfactory_placode0.94621011
95MP0003935_abnormal_craniofacial_develop0.94551680
96MP0001661_extended_life_span0.94429575
97MP0003136_yellow_coat_color0.94256914
98MP0005085_abnormal_gallbladder_physiolo0.93895126
99MP0005508_abnormal_skeleton_morphology0.93805372
100MP0003115_abnormal_respiratory_system0.93701691
101MP0003755_abnormal_palate_morphology0.92501299
102MP0001984_abnormal_olfaction0.91803004
103MP0002234_abnormal_pharynx_morphology0.91770474
104MP0000920_abnormal_myelination0.91623949
105MP0001765_abnormal_ion_homeostasis0.91488477
106MP0004510_myositis0.90854954
107MP0003566_abnormal_cell_adhesion0.90442090
108MP0002896_abnormal_bone_mineralization0.90119402
109MP0005197_abnormal_uvea_morphology0.90024777
110MP0003705_abnormal_hypodermis_morpholog0.89638997
111MP0003011_delayed_dark_adaptation0.86177739
112MP0002084_abnormal_developmental_patter0.85454435
113MP0000266_abnormal_heart_morphology0.83003599
114MP0009643_abnormal_urine_homeostasis0.81429873
115MP0000163_abnormal_cartilage_morphology0.81428609
116MP0005377_hearing/vestibular/ear_phenot0.80143982
117MP0003878_abnormal_ear_physiology0.80143982
118MP0000579_abnormal_nail_morphology0.79687839
119MP0000432_abnormal_head_morphology0.79297895
120MP0000467_abnormal_esophagus_morphology0.79286173
121MP0002085_abnormal_embryonic_tissue0.77973824
122MP0003385_abnormal_body_wall0.75846269
123MP0002133_abnormal_respiratory_system0.75736269
124MP0005388_respiratory_system_phenotype0.75736269
125MP0002282_abnormal_trachea_morphology0.75223889
126MP0005023_abnormal_wound_healing0.75179695
127MP0004147_increased_porphyrin_level0.74993955
128MP0003941_abnormal_skin_development0.74280947
129MP0002114_abnormal_axial_skeleton0.73882050
130MP0002332_abnormal_exercise_endurance0.73386594
131MP0002128_abnormal_blood_circulation0.72987983
132MP0001299_abnormal_eye_distance/0.72892105
133MP0005595_abnormal_vascular_smooth0.72125480
134MP0008872_abnormal_physiological_respon0.71326544
135MP0003252_abnormal_bile_duct0.71012166
136MP0003186_abnormal_redox_activity0.70883583
137MP0008932_abnormal_embryonic_tissue0.70556025
138MP0002060_abnormal_skin_morphology0.70502078
139MP0003936_abnormal_reproductive_system0.70340931
140MP0009780_abnormal_chondrocyte_physiolo0.69487275
141MP0010386_abnormal_urinary_bladder0.69090123
142MP0000049_abnormal_middle_ear0.68986064
143MP0005365_abnormal_bile_salt0.67965489
144MP0001727_abnormal_embryo_implantation0.61574935
145MP0000767_abnormal_smooth_muscle0.61121159
146MP0004134_abnormal_chest_morphology0.60389530
147MP0002115_abnormal_skeleton_extremities0.60169190
148MP0006054_spinal_hemorrhage0.59936953
149MP0004019_abnormal_vitamin_homeostasis0.58385335
150MP0000534_abnormal_ureter_morphology0.56710469
151MP0002971_abnormal_brown_adipose0.56345578
152MP0002933_joint_inflammation0.55079420

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.85304010
2Ventricular tachycardia (HP:0004756)5.29125076
3Muscle fiber splitting (HP:0003555)4.97599259
4Atrial fibrillation (HP:0005110)4.94528241
5Primary atrial arrhythmia (HP:0001692)4.53653803
6Right ventricular cardiomyopathy (HP:0011663)4.45849077
7Calf muscle hypertrophy (HP:0008981)4.42337348
8Supraventricular tachycardia (HP:0004755)4.30567406
9Abnormality of the calf musculature (HP:0001430)4.28814715
10Supraventricular arrhythmia (HP:0005115)4.24211521
11Lipoatrophy (HP:0100578)4.14859573
12Muscle hypertrophy of the lower extremities (HP:0008968)4.12893731
13Preaxial foot polydactyly (HP:0001841)3.58279293
14Syncope (HP:0001279)3.57892619
15Exercise-induced muscle cramps (HP:0003710)3.48685864
16Hyporeflexia of lower limbs (HP:0002600)3.44902568
17Increased connective tissue (HP:0009025)3.41628484
18Dilated cardiomyopathy (HP:0001644)3.37584564
19Prolonged QT interval (HP:0001657)3.22678753
20Exercise-induced myalgia (HP:0003738)3.20782865
21Abnormality of the middle phalanges of the toes (HP:0010183)3.17247448
22Increased circulating renin level (HP:0000848)3.16604440
23Metabolic alkalosis (HP:0200114)3.15810024
24Shawl scrotum (HP:0000049)3.15489988
25Broad metatarsal (HP:0001783)3.04060514
26Premature rupture of membranes (HP:0001788)2.98209726
27Complement deficiency (HP:0004431)2.94790844
28Hypokalemic alkalosis (HP:0001949)2.94141992
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87963380
30Myoglobinuria (HP:0002913)2.87003085
31Abnormal pancreas size (HP:0012094)2.86053311
32Ventricular arrhythmia (HP:0004308)2.84192656
33Partial duplication of thumb phalanx (HP:0009944)2.81380235
34Palpitations (HP:0001962)2.80095365
35Abnormal connection of the cardiac segments (HP:0011545)2.79981638
36Abnormal ventriculo-arterial connection (HP:0011563)2.79981638
37Transposition of the great arteries (HP:0001669)2.79981638
38Short middle phalanx of the 5th finger (HP:0004220)2.79389051
39Hypomagnesemia (HP:0002917)2.78377658
40Abnormality of the left ventricular outflow tract (HP:0011103)2.77214644
41Subaortic stenosis (HP:0001682)2.77214644
42Soft skin (HP:0000977)2.75235455
43Ketoacidosis (HP:0001993)2.72932595
44EMG: myopathic abnormalities (HP:0003458)2.71713650
45Bundle branch block (HP:0011710)2.69219134
46Abnormal umbilical cord blood vessels (HP:0011403)2.67993591
47Single umbilical artery (HP:0001195)2.67993591
48Abnormality of the fetal cardiovascular system (HP:0010948)2.67993591
49Stenosis of the external auditory canal (HP:0000402)2.67772458
50Pulmonary artery stenosis (HP:0004415)2.64577311
51Abnormality of the aortic arch (HP:0012303)2.61352199
52Increased variability in muscle fiber diameter (HP:0003557)2.55212010
53Distal lower limb muscle weakness (HP:0009053)2.54539069
54Polyuria (HP:0000103)2.53862118
55Abnormal atrioventricular conduction (HP:0005150)2.51422050
56Partial duplication of the phalanx of hand (HP:0009999)2.49929820
57Cutaneous finger syndactyly (HP:0010554)2.48457119
58Turricephaly (HP:0000262)2.47227712
59Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.46671977
60Proximal tubulopathy (HP:0000114)2.46596048
61Heart block (HP:0012722)2.46201149
62Acute necrotizing encephalopathy (HP:0006965)2.46159928
63Facial shape deformation (HP:0011334)2.45549353
64Potter facies (HP:0002009)2.45549353
65Atrioventricular block (HP:0001678)2.45452445
66Generalized aminoaciduria (HP:0002909)2.44252160
67Hypoplastic ischia (HP:0003175)2.41859882
68Hypoplasia of the iris (HP:0007676)2.41797479
69Short hallux (HP:0010109)2.41606266
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.37070697
71Polydipsia (HP:0001959)2.35804395
72Abnormal drinking behavior (HP:0030082)2.35804395
73Acute encephalopathy (HP:0006846)2.34783049
74Shallow orbits (HP:0000586)2.34662201
75Abnormal mitochondria in muscle tissue (HP:0008316)2.33680504
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32230376
77Dicarboxylic aciduria (HP:0003215)2.32230376
78Abnormal urine output (HP:0012590)2.32044490
79Cutaneous syndactyly (HP:0012725)2.30006241
80Aplasia involving bones of the extremities (HP:0009825)2.29350027
81Aplasia involving bones of the upper limbs (HP:0009823)2.29350027
82Hepatic necrosis (HP:0002605)2.28392690
83Abnormality of complement system (HP:0005339)2.28379517
84Hyperglycinuria (HP:0003108)2.28340173
85Difficulty running (HP:0009046)2.27547786
86Bicornuate uterus (HP:0000813)2.26790159
87Ventricular fibrillation (HP:0001663)2.25357686
88Abnormality of renal excretion (HP:0011036)2.24259688
89Abnormality of fatty-acid metabolism (HP:0004359)2.22173365
90Tracheal stenosis (HP:0002777)2.22002840
91Prolonged partial thromboplastin time (HP:0003645)2.21968069
92Abnormality of chloride homeostasis (HP:0011422)2.19872404
93Myotonia (HP:0002486)2.19571530
94Abnormality of the labia minora (HP:0012880)2.14801630
95Vitreoretinal degeneration (HP:0000655)2.13932417
96Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13570636
97Asymmetric septal hypertrophy (HP:0001670)2.12592785
98Abnormality of renin-angiotensin system (HP:0000847)2.12085280
99Hip contracture (HP:0003273)2.11429327
100Hypoplastic left heart (HP:0004383)2.10773970
101Abnormality of the phalanges of the hallux (HP:0010057)2.10678677
102Abnormality of the ischium (HP:0003174)2.10400828
103Gout (HP:0001997)2.10247316
104Maternal diabetes (HP:0009800)2.09431601
105Hyperactive renin-angiotensin system (HP:0000841)2.08640325
106Broad distal phalanx of finger (HP:0009836)2.06578967
107Fused cervical vertebrae (HP:0002949)2.05504927
108Limited hip movement (HP:0008800)2.05051478
109Coronal craniosynostosis (HP:0004440)2.04747221
110Abnormality of the phalanges of the 5th finger (HP:0004213)2.04280575
111Progressive macrocephaly (HP:0004481)2.04186569
112Abnormality of magnesium homeostasis (HP:0004921)2.04134585
113Ketosis (HP:0001946)2.04042110
114Spinal rigidity (HP:0003306)2.03305495
115Neonatal short-limb short stature (HP:0008921)2.02921395
116Aplasia/Hypoplasia of the hallux (HP:0008362)2.01921130
117Abnormality of glycine metabolism (HP:0010895)2.01689243
118Abnormality of serine family amino acid metabolism (HP:0010894)2.01689243
119Abnormal EKG (HP:0003115)1.99849319
120Absent radius (HP:0003974)1.99794979
121Abnormality of skeletal muscle fiber size (HP:0012084)1.98613981
122Hyperuricemia (HP:0002149)1.97213010
123Increased purine levels (HP:0004368)1.97213010
124Patent foramen ovale (HP:0001655)1.96541952
125Periauricular skin pits (HP:0100277)1.96326002
126Preauricular pit (HP:0004467)1.96326002
127Enlarged kidneys (HP:0000105)1.95425267
128Palmoplantar keratoderma (HP:0000982)1.94952315
129Hyperaldosteronism (HP:0000859)1.94858595
130Diaphragmatic weakness (HP:0009113)1.94472845
131Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.92895539
132Esophageal atresia (HP:0002032)1.92106659
133Hepatocellular necrosis (HP:0001404)1.91878354
134Choanal stenosis (HP:0000452)1.91808315
135Carpal synostosis (HP:0009702)1.90693120
136Aplasia involving forearm bones (HP:0009822)1.89509215
137Absent forearm bone (HP:0003953)1.89509215
138Cerebral edema (HP:0002181)1.88493123
139Broad thumb (HP:0011304)1.87980459
140Abnormality of the distal phalanges of the toes (HP:0010182)1.87596958
141Myelomeningocele (HP:0002475)1.87121544
142Foot dorsiflexor weakness (HP:0009027)1.86823852
143Rhabdomyolysis (HP:0003201)1.85952227
144Scapular winging (HP:0003691)1.85443696
145Wrist flexion contracture (HP:0001239)1.84772328
146Deep venous thrombosis (HP:0002625)1.84684643
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.84554753
148Abnormality of the umbilical cord (HP:0010881)1.84496919
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83637761
150Ulnar bowing (HP:0003031)1.83544170
151Glycosuria (HP:0003076)1.83477583
152Abnormality of urine glucose concentration (HP:0011016)1.83477583
153Bifid tongue (HP:0010297)1.82927498
154Synostosis of carpal bones (HP:0005048)1.82791501
155Mitochondrial inheritance (HP:0001427)1.81955714
156Bilateral microphthalmos (HP:0007633)1.79327235
157Protrusio acetabuli (HP:0003179)1.79325665
158Left ventricular hypertrophy (HP:0001712)1.79120159
159Abnormality of glycolysis (HP:0004366)1.79017976
160Increased serum pyruvate (HP:0003542)1.79017976
161Bifid scrotum (HP:0000048)1.78970153
162Hyperglycinemia (HP:0002154)1.78775988
163Abnormality of the foot musculature (HP:0001436)1.78685184
164Aortic dissection (HP:0002647)1.77794069
165Cardiovascular calcification (HP:0011915)1.77686358
166Fragile skin (HP:0001030)1.77084142
167Ectopia lentis (HP:0001083)1.76228138
168Oligomenorrhea (HP:0000876)1.76061604
169Short 5th finger (HP:0009237)1.75324471
170Type 1 muscle fiber predominance (HP:0003803)1.75203145
171Labial hypoplasia (HP:0000066)1.74956223
172Absent toe (HP:0010760)1.74833306
173Increased muscle lipid content (HP:0009058)1.74700417
174Aplasia of the phalanges of the hand (HP:0009802)1.74016772
175Thickened helices (HP:0000391)1.73884864
176Hypoplastic female external genitalia (HP:0012815)1.70173590
177Osteomalacia (HP:0002749)1.69617614
178Absent epiphyses (HP:0010577)1.69173636
179Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69173636
180Renal dysplasia (HP:0000110)1.68315551
181Congenital malformation of the right heart (HP:0011723)1.67903453
182Double outlet right ventricle (HP:0001719)1.67903453
183Duplication of thumb phalanx (HP:0009942)1.67510967
184Intrahepatic cholestasis (HP:0001406)1.67378216
185Pterygium (HP:0001059)1.66106365
186Anal stenosis (HP:0002025)1.65019850
187Abnormality of the nasal septum (HP:0000419)1.64255250
188Triphalangeal thumb (HP:0001199)1.64182679
189Mixed hearing impairment (HP:0000410)1.63824614
190Atrophic scars (HP:0001075)1.63558225
191Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62704305
192Broad finger (HP:0001500)1.62287106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.84496526
2STK394.12627396
3TTN3.78751210
4MYLK3.33106337
5OXSR13.30741186
6MAP3K122.63036213
7OBSCN2.62786893
8PIK3CA2.50627355
9LMTK22.43091104
10STK38L2.42295159
11PDK42.39167277
12PDK32.39167277
13DMPK2.35762621
14BCKDK2.34635957
15PHKG12.33772158
16PHKG22.33772158
17EPHB22.26375707
18RIPK12.07546033
19WNK11.94378724
20TIE11.93608315
21EEF2K1.90508426
22PBK1.88002100
23MUSK1.73263528
24PAK31.70299001
25WNK31.69999093
26PDK21.67674831
27MAP3K91.64718846
28ERBB41.61112731
29EPHA21.58681306
30ARAF1.56816609
31INSRR1.50619604
32TTK1.48024853
33EPHB11.44989867
34PKN11.44928879
35MAP4K21.40063363
36TRIB31.39082229
37GRK71.35967445
38PRKD11.35479728
39CDC71.35203220
40TGFBR11.33023152
41MET1.28874003
42STK241.23011353
43EPHA31.21523002
44CAMK2D1.20165041
45PINK11.19532075
46MTOR1.18433101
47DDR21.11400786
48LATS11.10747293
49FER1.09650239
50TRPM71.08460841
51PLK41.07988437
52ROCK11.05144545
53PTK2B1.03567763
54ROCK21.02709677
55NEK21.01931756
56PRKCE0.98535178
57PRKAA20.94737729
58MKNK20.94299942
59DYRK20.93166298
60FGFR20.89482271
61PAK40.82855496
62STK380.82714765
63SMG10.82706753
64ERN10.82292175
65MST1R0.82256724
66PDGFRA0.79947708
67AURKB0.79250160
68MAPK150.79085562
69GRK10.78814416
70LATS20.78585843
71CASK0.78502694
72MKNK10.78362021
73AKT20.76984628
74CAMK2A0.76657976
75LRRK20.74991440
76NME10.74100837
77TGFBR20.71679851
78BUB10.70139922
79RPS6KA60.69871925
80MAPK120.69849996
81ILK0.69377503
82PIM20.68919280
83PRKD20.68912068
84ZAK0.68665464
85NEK10.68593258
86MAP3K30.66431025
87FLT30.66387323
88CAMK1G0.65911593
89BRSK20.62770274
90PRKCG0.61505783
91MELK0.61263418
92BCR0.60618956
93CSNK1G10.60098308
94MAPK70.59965490
95MAP3K110.58469043
96PASK0.57001399
97CAMK1D0.56953141
98MAP3K70.56935565
99PRKCH0.56796988
100PKN20.56591986
101DYRK30.56588541
102SGK4940.55651238
103SGK2230.55651238
104CDC42BPA0.54308751
105BMPR1B0.53355394
106PRKAA10.53053809
107FGFR40.51867247
108VRK20.51348125
109PRKACA0.51208389
110MAP2K20.50131221
111TAF10.48961752
112AURKA0.48758056
113RPS6KA10.47941749
114WEE10.47893586
115CAMK2G0.47377289
116MAPK10.46944333
117PDPK10.46451674
118PRKDC0.46325115
119PRKG20.45593226
120SIK10.45191214
121MAP3K10.43917359
122PRKACB0.43593330
123MARK30.43361350
124STK40.43354464
125ERBB20.43084975
126ACVR1B0.42774207
127CAMK10.42413501
128RPS6KA20.41806774
129IRAK10.41695830
130PDGFRB0.41231436
131MAP2K10.41049379
132NEK60.38664127
133CAMK2B0.37730932
134PAK20.37700127
135DAPK30.37449740
136MAPKAPK50.36955500
137GSK3A0.36303708
138SGK10.35928364
139CAMK40.34633058
140STK30.34518061
141ADRBK10.34440876
142PRKG10.33808130
143PRKACG0.32981663
144BMX0.32599297
145NME20.32500183
146NTRK10.30569984
147NUAK10.30489622
148PAK60.30231877
149IRAK20.29664611
150PTK20.28394664
151PRKD30.25071368
152ICK0.23166901
153RPS6KL10.22155309
154RPS6KC10.22155309
155TNIK0.21456941
156FGFR10.21290291

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.89284134
2Propanoate metabolism_Homo sapiens_hsa006403.67751604
3Cardiac muscle contraction_Homo sapiens_hsa042603.16500053
4Dilated cardiomyopathy_Homo sapiens_hsa054142.93393665
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89904471
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.89864927
7Oxidative phosphorylation_Homo sapiens_hsa001902.87035956
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81861080
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77745898
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76972770
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.58767526
12Retinol metabolism_Homo sapiens_hsa008302.52191424
13Parkinsons disease_Homo sapiens_hsa050122.47007607
14Fatty acid degradation_Homo sapiens_hsa000712.41043752
15Butanoate metabolism_Homo sapiens_hsa006502.29750242
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23981423
17Fatty acid metabolism_Homo sapiens_hsa012122.20608079
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.20602087
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17460630
20Complement and coagulation cascades_Homo sapiens_hsa046102.17060755
21Fatty acid elongation_Homo sapiens_hsa000622.16734450
22Alzheimers disease_Homo sapiens_hsa050102.07096758
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04377258
24Chemical carcinogenesis_Homo sapiens_hsa052042.00976751
25Arginine biosynthesis_Homo sapiens_hsa002201.98379107
26ECM-receptor interaction_Homo sapiens_hsa045121.91937544
27Pyruvate metabolism_Homo sapiens_hsa006201.85005566
28Nitrogen metabolism_Homo sapiens_hsa009101.81762340
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79072061
30Caffeine metabolism_Homo sapiens_hsa002321.78947957
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.78263676
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69264056
33Tyrosine metabolism_Homo sapiens_hsa003501.61305761
34Histidine metabolism_Homo sapiens_hsa003401.58019425
35Carbon metabolism_Homo sapiens_hsa012001.53860420
36Protein digestion and absorption_Homo sapiens_hsa049741.50452698
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49276864
38Bile secretion_Homo sapiens_hsa049761.47536001
39Huntingtons disease_Homo sapiens_hsa050161.45044548
40Biosynthesis of amino acids_Homo sapiens_hsa012301.44206579
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.42554357
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37116608
43PPAR signaling pathway_Homo sapiens_hsa033201.36078179
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.36070373
45Ribosome_Homo sapiens_hsa030101.26080162
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25956433
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22205933
48Focal adhesion_Homo sapiens_hsa045101.20768442
49Peroxisome_Homo sapiens_hsa041461.20024956
50Arginine and proline metabolism_Homo sapiens_hsa003301.19249163
51Circadian rhythm_Homo sapiens_hsa047101.18840733
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15032773
53beta-Alanine metabolism_Homo sapiens_hsa004101.12389695
54Pentose phosphate pathway_Homo sapiens_hsa000301.00778347
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00630434
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99530547
57Sulfur relay system_Homo sapiens_hsa041220.96010127
58Lysine degradation_Homo sapiens_hsa003100.95702787
59One carbon pool by folate_Homo sapiens_hsa006700.91967272
60Tryptophan metabolism_Homo sapiens_hsa003800.90603763
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90447011
62Wnt signaling pathway_Homo sapiens_hsa043100.90200092
63Viral myocarditis_Homo sapiens_hsa054160.89181530
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88611776
65Galactose metabolism_Homo sapiens_hsa000520.83545932
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83343985
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82866494
68Prion diseases_Homo sapiens_hsa050200.81576561
69Gastric acid secretion_Homo sapiens_hsa049710.79781115
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78445049
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.77106142
72Axon guidance_Homo sapiens_hsa043600.73719925
73Renin secretion_Homo sapiens_hsa049240.71563511
74Tight junction_Homo sapiens_hsa045300.70892884
75Starch and sucrose metabolism_Homo sapiens_hsa005000.70516200
76Sulfur metabolism_Homo sapiens_hsa009200.69464703
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68522362
78Calcium signaling pathway_Homo sapiens_hsa040200.65343373
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.64714675
80Basal cell carcinoma_Homo sapiens_hsa052170.64181709
81Arachidonic acid metabolism_Homo sapiens_hsa005900.64133093
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.62625979
83cAMP signaling pathway_Homo sapiens_hsa040240.60625239
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60598997
85Fructose and mannose metabolism_Homo sapiens_hsa000510.60445665
86Insulin resistance_Homo sapiens_hsa049310.58754986
87Amoebiasis_Homo sapiens_hsa051460.58332092
88Glutathione metabolism_Homo sapiens_hsa004800.58046936
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55879600
90Collecting duct acid secretion_Homo sapiens_hsa049660.55525835
91AMPK signaling pathway_Homo sapiens_hsa041520.53462105
92Glycerolipid metabolism_Homo sapiens_hsa005610.53179599
93Phenylalanine metabolism_Homo sapiens_hsa003600.52183031
94Proteoglycans in cancer_Homo sapiens_hsa052050.51336003
95Thyroid cancer_Homo sapiens_hsa052160.49905396
96Hedgehog signaling pathway_Homo sapiens_hsa043400.49128605
97Mineral absorption_Homo sapiens_hsa049780.48835831
98Fat digestion and absorption_Homo sapiens_hsa049750.48421007
99Oxytocin signaling pathway_Homo sapiens_hsa049210.47745017
100Sphingolipid metabolism_Homo sapiens_hsa006000.46533260
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46152432
102Melanoma_Homo sapiens_hsa052180.44067750
103Salivary secretion_Homo sapiens_hsa049700.43678281
104Ovarian steroidogenesis_Homo sapiens_hsa049130.43017837
105Adherens junction_Homo sapiens_hsa045200.42249271
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41961700
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41541009
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40962400
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40845401
110Ether lipid metabolism_Homo sapiens_hsa005650.39884133
111Vitamin B6 metabolism_Homo sapiens_hsa007500.39271524
112Fatty acid biosynthesis_Homo sapiens_hsa000610.39239268
113Glucagon signaling pathway_Homo sapiens_hsa049220.38695860
114Metabolic pathways_Homo sapiens_hsa011000.37304098
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36718231
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35743865
117Circadian entrainment_Homo sapiens_hsa047130.35292618
118Folate biosynthesis_Homo sapiens_hsa007900.35057278
119Taste transduction_Homo sapiens_hsa047420.33742888
120Ras signaling pathway_Homo sapiens_hsa040140.33621151
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.33561497
122Rap1 signaling pathway_Homo sapiens_hsa040150.33087084
123Hippo signaling pathway_Homo sapiens_hsa043900.32025205
124Notch signaling pathway_Homo sapiens_hsa043300.31710421
125Vitamin digestion and absorption_Homo sapiens_hsa049770.31651277
126Insulin signaling pathway_Homo sapiens_hsa049100.31113091
127Melanogenesis_Homo sapiens_hsa049160.29813272
128Other glycan degradation_Homo sapiens_hsa005110.29480891
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.28938003
130TGF-beta signaling pathway_Homo sapiens_hsa043500.28906012
131Gap junction_Homo sapiens_hsa045400.28370449
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28299480
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27836237
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27575458
135Renal cell carcinoma_Homo sapiens_hsa052110.27368358
136Thyroid hormone synthesis_Homo sapiens_hsa049180.27196777
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25559292
138Linoleic acid metabolism_Homo sapiens_hsa005910.24371106
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24183837
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.24168262
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24151599
142Basal transcription factors_Homo sapiens_hsa030220.23834185
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22345487

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