TRAC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)9.24896024
2negative thymic T cell selection (GO:0045060)9.21109997
3positive thymic T cell selection (GO:0045059)7.84832430
4regulation of isotype switching to IgG isotypes (GO:0048302)7.77200438
5thymic T cell selection (GO:0045061)7.54483762
6leukocyte aggregation (GO:0070486)7.37632952
7positive regulation of gamma-delta T cell activation (GO:0046645)7.30056584
8cytidine deamination (GO:0009972)7.25397110
9cytidine metabolic process (GO:0046087)7.25397110
10cytidine catabolic process (GO:0006216)7.25397110
11positive T cell selection (GO:0043368)7.00408935
12cellular response to interleukin-15 (GO:0071350)6.76567971
13T cell selection (GO:0045058)6.73046832
14pyrimidine ribonucleoside catabolic process (GO:0046133)6.68162251
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.48109694
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46596160
17response to interleukin-15 (GO:0070672)6.43926934
18regulation of T cell tolerance induction (GO:0002664)6.30897427
19regulation of gamma-delta T cell differentiation (GO:0045586)6.23905137
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.23771310
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.14034233
22negative regulation of cell killing (GO:0031342)6.14034233
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.03329783
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.03329783
25DNA deamination (GO:0045006)5.84479590
26T cell migration (GO:0072678)5.74668976
27* T cell receptor signaling pathway (GO:0050852)5.72375495
28* T cell costimulation (GO:0031295)5.66919967
29* lymphocyte costimulation (GO:0031294)5.63005023
30regulation of gamma-delta T cell activation (GO:0046643)5.57462843
31interferon-gamma production (GO:0032609)5.50864544
32sequestering of actin monomers (GO:0042989)5.37487854
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.28394779
34positive regulation of tolerance induction (GO:0002645)5.15871115
35positive regulation of alpha-beta T cell proliferation (GO:0046641)5.12214579
36regulation of alpha-beta T cell proliferation (GO:0046640)5.04145341
37antigen processing and presentation of endogenous antigen (GO:0019883)4.95769218
38regulation of interleukin-2 biosynthetic process (GO:0045076)4.82576128
39* antigen receptor-mediated signaling pathway (GO:0050851)4.74980117
40regulation of B cell receptor signaling pathway (GO:0050855)4.73697563
41regulation of T cell receptor signaling pathway (GO:0050856)4.66731133
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.63180794
43positive regulation of isotype switching (GO:0045830)4.58517280
44regulation of isotype switching (GO:0045191)4.53337041
45tolerance induction (GO:0002507)4.51083431
46regulation of tolerance induction (GO:0002643)4.46556520
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.33835826
48positive regulation of natural killer cell mediated immunity (GO:0002717)4.29449465
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.29449465
50positive regulation of T cell mediated cytotoxicity (GO:0001916)4.20915663
51positive regulation of lamellipodium assembly (GO:0010592)4.18349968
52negative regulation of T cell apoptotic process (GO:0070233)4.09151644
53regulation of T cell mediated cytotoxicity (GO:0001914)4.08706121
54positive regulation of interleukin-2 production (GO:0032743)4.07951268
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.07176540
56regulation of natural killer cell mediated immunity (GO:0002715)4.07176540
57regulation of immunoglobulin mediated immune response (GO:0002889)4.06111388
58regulation of immunoglobulin production (GO:0002637)3.99378794
59positive regulation of DNA recombination (GO:0045911)3.98325241
60regulation of B cell mediated immunity (GO:0002712)3.90478250
61antigen processing and presentation via MHC class Ib (GO:0002475)3.89284884
62activated T cell proliferation (GO:0050798)3.87016100
63positive regulation of B cell differentiation (GO:0045579)3.86522426
64regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.86257275
65positive regulation of B cell mediated immunity (GO:0002714)3.86017661
66positive regulation of immunoglobulin mediated immune response (GO:0002891)3.86017661
67regulation of response to interferon-gamma (GO:0060330)3.84378700
68regulation of lymphocyte chemotaxis (GO:1901623)3.84185865
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.83993911
70regulation of regulatory T cell differentiation (GO:0045589)3.81094074
71regulation of activation of Janus kinase activity (GO:0010533)3.80004498
72regulation of defense response to virus by virus (GO:0050690)3.79347215
73leukocyte cell-cell adhesion (GO:0007159)3.79061681
74regulation of chronic inflammatory response (GO:0002676)3.77939286
75negative regulation of viral genome replication (GO:0045071)3.68414527
76positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67896598
77mast cell activation (GO:0045576)3.67292728
78negative regulation of T cell receptor signaling pathway (GO:0050860)3.66022897
79T cell differentiation (GO:0030217)3.65996946
80regulation of T cell chemotaxis (GO:0010819)3.65183629
81positive regulation of T cell chemotaxis (GO:0010820)3.65183629
82negative regulation by host of viral transcription (GO:0043922)3.62816105
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.60051044
84positive regulation of immunoglobulin production (GO:0002639)3.58494031
85actin nucleation (GO:0045010)3.57707433
86lymphocyte chemotaxis (GO:0048247)3.57341098
87positive regulation of humoral immune response (GO:0002922)3.56363168
88dendritic cell chemotaxis (GO:0002407)3.54369317
89T cell activation (GO:0042110)3.51960501
90negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50602290
91negative regulation of lymphocyte mediated immunity (GO:0002707)3.49037804
92NIK/NF-kappaB signaling (GO:0038061)3.48783406
93positive regulation of lymphocyte migration (GO:2000403)3.48579982
94regulation of immunoglobulin secretion (GO:0051023)3.47796112
95positive regulation of defense response to virus by host (GO:0002230)3.46216371
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.44782827
97positive regulation of interleukin-8 secretion (GO:2000484)3.44436243
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43886415
99positive regulation of granulocyte differentiation (GO:0030854)3.43122580
100regulation of interleukin-12 biosynthetic process (GO:0045075)3.41993926
101natural killer cell activation (GO:0030101)3.41670357
102negative regulation of type 2 immune response (GO:0002829)3.41428138
103positive regulation of cell killing (GO:0031343)3.39629348
104negative regulation of immunoglobulin mediated immune response (GO:0002890)3.38913179
105negative regulation of B cell mediated immunity (GO:0002713)3.38913179
106lymphocyte migration (GO:0072676)3.37589756
107cellular defense response (GO:0006968)3.36022882
108negative regulation of T cell mediated immunity (GO:0002710)3.34649230
109regulation of cell killing (GO:0031341)3.33356610
110B cell receptor signaling pathway (GO:0050853)3.30308018
111positive regulation of lamellipodium organization (GO:1902745)3.29079684
112* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.29013585
113regulation of interleukin-4 production (GO:0032673)3.28367067
114negative regulation of leukocyte mediated immunity (GO:0002704)3.27728905
115positive regulation of calcium-mediated signaling (GO:0050850)3.27063902
116positive regulation of macrophage differentiation (GO:0045651)3.25072366
117positive regulation of interleukin-4 production (GO:0032753)3.24093572
118pyrimidine nucleoside catabolic process (GO:0046135)3.23382606
119* positive regulation of T cell activation (GO:0050870)3.23374570
120alpha-beta T cell differentiation (GO:0046632)3.23282436
121positive regulation of T cell mediated immunity (GO:0002711)3.21296458
122regulation of lymphocyte mediated immunity (GO:0002706)3.18421878
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.18350969
124alpha-beta T cell activation (GO:0046631)3.16866466
125chemokine-mediated signaling pathway (GO:0070098)3.16320243
126regulation of B cell differentiation (GO:0045577)3.14023742
127cellular response to type I interferon (GO:0071357)3.13552327
128type I interferon signaling pathway (GO:0060337)3.13552327
129T cell homeostasis (GO:0043029)3.13223909
130response to type I interferon (GO:0034340)3.10545717
131dendritic cell migration (GO:0036336)3.10293366
132positive regulation of lymphocyte mediated immunity (GO:0002708)3.09578452
133regulation of interleukin-2 production (GO:0032663)3.08214224
134positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.07784742
135regulation of lymphocyte migration (GO:2000401)3.01420689
136regulation of alpha-beta T cell activation (GO:0046634)2.98036155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.79562912
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.08041349
3STAT4_19710469_ChIP-ChIP_TH1__Mouse3.77872363
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.77837676
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.75873062
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.67239948
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.66972737
8RUNX_20019798_ChIP-Seq_JUKART_Human3.55443684
9E2F7_22180533_ChIP-Seq_HELA_Human3.43274882
10MYB_26560356_Chip-Seq_TH2_Human3.28417965
11MYC_22102868_ChIP-Seq_BL_Human3.27233807
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.24132754
13MAF_26560356_Chip-Seq_TH1_Human3.02779431
14UTX_26944678_Chip-Seq_JUKART_Human2.81910885
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80520237
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74978507
17MYB_26560356_Chip-Seq_TH1_Human2.73595371
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54837089
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41294533
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37512405
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31766016
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.28635130
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.21447477
24MAF_26560356_Chip-Seq_TH2_Human2.19595207
25GATA3_27048872_Chip-Seq_THYMUS_Human2.01034220
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99098525
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93398222
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92243285
29VDR_21846776_ChIP-Seq_THP-1_Human1.90750131
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.82721309
31SPI1_23547873_ChIP-Seq_NB4_Human1.82676735
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74744164
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74464120
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69695649
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68020806
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67081201
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64002485
38VDR_23849224_ChIP-Seq_CD4+_Human1.60802977
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56742986
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.55974760
41FOXP3_21729870_ChIP-Seq_TREG_Human1.54927230
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.54199685
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.53692359
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51333093
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49862002
46VDR_24763502_ChIP-Seq_THP-1_Human1.46923820
47TCF7_22412390_ChIP-Seq_EML_Mouse1.46859310
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45803802
49CIITA_25753668_ChIP-Seq_RAJI_Human1.41685063
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41670842
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37879735
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.37463283
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33376122
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31054486
55KDM2B_26808549_Chip-Seq_DND41_Human1.29715203
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28935956
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.28806127
58SPI1_23127762_ChIP-Seq_K562_Human1.23779630
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.22841359
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22171169
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.21993177
62GATA3_26560356_Chip-Seq_TH2_Human1.20586147
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18254980
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15967021
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15495519
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14731829
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14357614
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13923416
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12548028
70BCL6_27268052_Chip-Seq_Bcells_Human1.11343959
71SCL_19346495_ChIP-Seq_HPC-7_Human1.11075230
72XRN2_22483619_ChIP-Seq_HELA_Human1.08379039
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07476636
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06274208
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05331079
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04380748
77PU_27001747_Chip-Seq_BMDM_Mouse1.03645123
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02782228
79ELK1_19687146_ChIP-ChIP_HELA_Human1.02006118
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99667687
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98484852
82GATA1_22025678_ChIP-Seq_K562_Human0.96458621
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.95087887
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94177254
85GATA3_26560356_Chip-Seq_TH1_Human0.93500422
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92680315
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92167691
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91449372
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.90880292
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90495010
91FOXM1_23109430_ChIP-Seq_U2OS_Human0.89716759
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89022585
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87805467
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87761877
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.87341970
96SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86155496
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85694803
98BCOR_27268052_Chip-Seq_Bcells_Human0.85344822
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85190352
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85115112
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84738038
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83605834
103MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83366222
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82843341
105P300_27268052_Chip-Seq_Bcells_Human0.81934216
106MYC_18358816_ChIP-ChIP_MESCs_Mouse0.79580697
107VDR_24787735_ChIP-Seq_THP-1_Human0.79232532
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78256172
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77874809
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76710505
111GABP_19822575_ChIP-Seq_HepG2_Human0.76692891
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.76407587
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76227537
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76110931
115RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75847179
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75780146
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75185396
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.74370393
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70082753
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69390441
121SPI1_20517297_ChIP-Seq_HL60_Human0.68997525
122SA1_27219007_Chip-Seq_Bcells_Human0.68377902
123TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.65724494
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65099538
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63908603
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.63653559
127SMRT_27268052_Chip-Seq_Bcells_Human0.62441852
128NANOG_20526341_ChIP-Seq_ESCs_Human0.62392387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.25959136
2MP0005671_abnormal_response_to5.28910753
3MP0000685_abnormal_immune_system3.98651570
4MP0001835_abnormal_antigen_presentation3.68464309
5MP0002166_altered_tumor_susceptibility3.43271726
6MP0001800_abnormal_humoral_immune3.14501676
7MP0006082_CNS_inflammation3.07072491
8MP0009333_abnormal_splenocyte_physiolog3.05102753
9MP0005000_abnormal_immune_tolerance3.04085237
10MP0001790_abnormal_immune_system3.02124222
11MP0005387_immune_system_phenotype3.02124222
12MP0009785_altered_susceptibility_to2.98937394
13MP0002398_abnormal_bone_marrow2.91141396
14MP0003724_increased_susceptibility_to2.90548283
15MP0002420_abnormal_adaptive_immunity2.90415850
16MP0001819_abnormal_immune_cell2.85446289
17MP0002723_abnormal_immune_serum2.82856826
18MP0002006_tumorigenesis2.81451155
19MP0002405_respiratory_system_inflammati2.72750149
20MP0000703_abnormal_thymus_morphology2.71369631
21MP0005025_abnormal_response_to2.55024435
22MP0000716_abnormal_immune_system2.50270513
23MP0002452_abnormal_antigen_presenting2.49190843
24MP0003436_decreased_susceptibility_to2.40084612
25MP0002933_joint_inflammation2.38942015
26MP0002722_abnormal_immune_system2.38347143
27MP0003866_abnormal_defecation2.31907319
28MP0000689_abnormal_spleen_morphology2.24238608
29MP0004947_skin_inflammation2.21233193
30MP0002396_abnormal_hematopoietic_system2.20882111
31MP0001873_stomach_inflammation2.04159278
32MP0010155_abnormal_intestine_physiology2.03386242
33MP0002429_abnormal_blood_cell2.02023051
34MP0003300_gastrointestinal_ulcer1.98180081
35MP0002148_abnormal_hypersensitivity_rea1.87452474
36MP0004510_myositis1.67459332
37MP0002419_abnormal_innate_immunity1.66608585
38MP0001853_heart_inflammation1.63327572
39MP0001845_abnormal_inflammatory_respons1.61561927
40MP0000858_altered_metastatic_potential1.53631576
41MP0005310_abnormal_salivary_gland1.51487896
42MP0005464_abnormal_platelet_physiology1.46217082
43MP0004381_abnormal_hair_follicle1.43718752
44MP0002277_abnormal_respiratory_mucosa1.41802542
45MP0003303_peritoneal_inflammation1.23593528
46MP0003448_altered_tumor_morphology1.15463453
47MP0001533_abnormal_skeleton_physiology1.14771624
48MP0008469_abnormal_protein_level1.12793087
49MP0001851_eye_inflammation1.12357140
50MP0010352_gastrointestinal_tract_polyps1.10757840
51MP0002019_abnormal_tumor_incidence1.09152616
52MP0002132_abnormal_respiratory_system1.04972508
53MP0001348_abnormal_lacrimal_gland1.01941626
54MP0002009_preneoplasia1.00085371
55MP0005075_abnormal_melanosome_morpholog0.90395809
56MP0000604_amyloidosis0.89718167
57MP0002822_catalepsy0.89155329
58MP0004808_abnormal_hematopoietic_stem0.88688954
59MP0005023_abnormal_wound_healing0.87787981
60MP0000490_abnormal_crypts_of0.86119163
61MP0003045_fibrosis0.81693282
62MP0009763_increased_sensitivity_to0.79999838
63MP0003077_abnormal_cell_cycle0.79180177
64MP0000465_gastrointestinal_hemorrhage0.77864160
65MP0004957_abnormal_blastocyst_morpholog0.77224681
66MP0008057_abnormal_DNA_replication0.75801823
67MP0001919_abnormal_reproductive_system0.75477055
68MP0001243_abnormal_dermal_layer0.70246373
69MP0002998_abnormal_bone_remodeling0.69854641
70MP0003786_premature_aging0.69643320
71MP0003693_abnormal_embryo_hatching0.68827397
72MP0002138_abnormal_hepatobiliary_system0.67594583
73MP0009765_abnormal_xenobiotic_induced0.67144421
74MP0003183_abnormal_peptide_metabolism0.65427459
75MP0003329_amyloid_beta_deposits0.65109003
76MP0003878_abnormal_ear_physiology0.64262906
77MP0005377_hearing/vestibular/ear_phenot0.64262906
78MP0009764_decreased_sensitivity_to0.61999836
79MP0008007_abnormal_cellular_replicative0.61007912
80MP0010094_abnormal_chromosome_stability0.58559210
81MP0001765_abnormal_ion_homeostasis0.58401816
82MP0000477_abnormal_intestine_morphology0.57012808
83MP0003795_abnormal_bone_structure0.56184155
84MP0000372_irregular_coat_pigmentation0.55121178
85MP0002163_abnormal_gland_morphology0.53750284
86MP0003075_altered_response_to0.53280572
87MP0005379_endocrine/exocrine_gland_phen0.52581091
88MP0000609_abnormal_liver_physiology0.52446199
89MP0001191_abnormal_skin_condition0.52083321
90MP0003453_abnormal_keratinocyte_physiol0.50731444
91MP0005390_skeleton_phenotype0.49589232
92MP0005076_abnormal_cell_differentiation0.49314156
93MP0003806_abnormal_nucleotide_metabolis0.49209160
94MP0002693_abnormal_pancreas_physiology0.47562025
95MP0000920_abnormal_myelination0.47047137
96MP0002877_abnormal_melanocyte_morpholog0.46721561
97MP0002168_other_aberrant_phenotype0.46502442
98MP0003172_abnormal_lysosome_physiology0.45916841
99MP0008961_abnormal_basal_metabolism0.45468644
100MP0010234_abnormal_vibrissa_follicle0.45140923
101MP0001881_abnormal_mammary_gland0.44708680
102MP0002095_abnormal_skin_pigmentation0.44624367
103MP0009643_abnormal_urine_homeostasis0.44540052
104MP0002136_abnormal_kidney_physiology0.43882239
105MP0001501_abnormal_sleep_pattern0.43334939
106MP0000313_abnormal_cell_death0.43214837
107MP0005397_hematopoietic_system_phenotyp0.41757761
108MP0001545_abnormal_hematopoietic_system0.41757761
109MP0008058_abnormal_DNA_repair0.40585979
110MP0001216_abnormal_epidermal_layer0.40500269
111MP0002909_abnormal_adrenal_gland0.40242577
112MP0000015_abnormal_ear_pigmentation0.40108683
113MP0001663_abnormal_digestive_system0.38950282
114MP0005166_decreased_susceptibility_to0.38637741
115MP0002876_abnormal_thyroid_physiology0.38331458
116MP0000249_abnormal_blood_vessel0.37801709
117MP0003252_abnormal_bile_duct0.37490304
118MP0005584_abnormal_enzyme/coenzyme_acti0.37413366
119MP0008872_abnormal_physiological_respon0.36982861
120MP0002083_premature_death0.36706248
121MP0008873_increased_physiological_sensi0.36629600
122MP0004130_abnormal_muscle_cell0.35990507
123MP0005451_abnormal_body_composition0.35532209
124MP0004883_abnormal_blood_vessel0.34989568
125MP0003111_abnormal_nucleus_morphology0.34847273
126MP0001542_abnormal_bone_strength0.34497999
127MP0001986_abnormal_taste_sensitivity0.34003783
128MP0004145_abnormal_muscle_electrophysio0.33002060
129MP0005645_abnormal_hypothalamus_physiol0.32816905

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.92387067
2Abnormality of T cell number (HP:0011839)7.68099832
3Severe combined immunodeficiency (HP:0004430)7.58609800
4Combined immunodeficiency (HP:0005387)6.93537001
5Stomatitis (HP:0010280)6.78170337
6Increased IgM level (HP:0003496)6.39386854
7Elevated erythrocyte sedimentation rate (HP:0003565)6.20350248
8Abnormality of T cells (HP:0002843)5.95638255
9IgG deficiency (HP:0004315)5.71611946
10Recurrent bronchitis (HP:0002837)5.49445744
11Eczematoid dermatitis (HP:0000976)5.38087010
12Recurrent fungal infections (HP:0002841)4.60174737
13Autoimmune hemolytic anemia (HP:0001890)4.58369000
14Chronic diarrhea (HP:0002028)4.50186945
15Panhypogammaglobulinemia (HP:0003139)4.49950756
16IgM deficiency (HP:0002850)4.41780039
17Nasal polyposis (HP:0100582)4.32081241
18Abnormality of eosinophils (HP:0001879)4.20965613
19Recurrent cutaneous fungal infections (HP:0011370)4.17700841
20Chronic mucocutaneous candidiasis (HP:0002728)4.17700841
21Abnormality of T cell physiology (HP:0011840)4.15395885
22Chronic otitis media (HP:0000389)3.93039198
23Lymphopenia (HP:0001888)3.91988003
24Thyroiditis (HP:0100646)3.89092651
25Abnormality of cells of the lymphoid lineage (HP:0012140)3.80184769
26Hypoplasia of the thymus (HP:0000778)3.80122753
27Abnormality of macrophages (HP:0004311)3.78114186
28Myositis (HP:0100614)3.74474788
29Hypoproteinemia (HP:0003075)3.73377709
30Joint swelling (HP:0001386)3.66230782
31Leukocytosis (HP:0001974)3.64158522
32Abnormality of the nasal mucosa (HP:0000433)3.58350136
33Hypergammaglobulinemia (HP:0010702)3.49999763
34Recurrent viral infections (HP:0004429)3.48064316
35IgA deficiency (HP:0002720)3.43156794
36Gastrointestinal infarctions (HP:0005244)3.43038933
37Eosinophilia (HP:0001880)3.34941238
38B lymphocytopenia (HP:0010976)3.26374065
39Abnormality of B cell number (HP:0010975)3.26374065
40Recurrent bacterial skin infections (HP:0005406)3.18353932
41Bronchitis (HP:0012387)3.10883523
42Abnormality of the fingertips (HP:0001211)3.07481537
43Pustule (HP:0200039)3.04488148
44Granulocytopenia (HP:0001913)2.93525624
45Recurrent sinusitis (HP:0011108)2.88223184
46Lymphoma (HP:0002665)2.87341744
47Pulmonary infiltrates (HP:0002113)2.81277039
48Vasculitis (HP:0002633)2.79775692
49Optic neuritis (HP:0100653)2.78548097
50Retrobulbar optic neuritis (HP:0100654)2.78548097
51Hemoptysis (HP:0002105)2.72487513
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.59040557
53Orchitis (HP:0100796)2.54906095
54Abnormality of the pleura (HP:0002103)2.52637662
55Recurrent otitis media (HP:0000403)2.51703236
56Increased density of long bones (HP:0006392)2.50760645
57Meningitis (HP:0001287)2.50656791
58Acute hepatic failure (HP:0006554)2.46211865
59Amyotrophic lateral sclerosis (HP:0007354)2.46183592
60Thrombocytosis (HP:0001894)2.42938731
61Mediastinal lymphadenopathy (HP:0100721)2.41570824
62Recurrent skin infections (HP:0001581)2.39682233
63Chronic obstructive pulmonary disease (HP:0006510)2.39584799
64Obstructive lung disease (HP:0006536)2.39584799
65Gingivitis (HP:0000230)2.37840922
66Recurrent abscess formation (HP:0002722)2.33638273
67Encephalitis (HP:0002383)2.33611484
68Hemiplegia (HP:0002301)2.30909124
69Agammaglobulinemia (HP:0004432)2.26324783
70Hepatitis (HP:0012115)2.26094676
71Hypochromic anemia (HP:0001931)2.21682776
72Basal cell carcinoma (HP:0002671)2.19714580
73Reduced subcutaneous adipose tissue (HP:0003758)2.19305066
74Pulmonary fibrosis (HP:0002206)2.18708688
75Ureteral obstruction (HP:0006000)2.16646546
76Inflammation of the large intestine (HP:0002037)2.15934319
77Skin rash (HP:0000988)2.13583795
78Keratoconjunctivitis sicca (HP:0001097)2.11223530
79Glomerulopathy (HP:0100820)2.11014525
80Arterial thrombosis (HP:0004420)2.04983579
81Autoimmune thrombocytopenia (HP:0001973)2.01561613
82Gangrene (HP:0100758)2.01469932
83Chest pain (HP:0100749)2.01357187
84Gastrointestinal inflammation (HP:0004386)2.01299215
85Recurrent gram-negative bacterial infections (HP:0005420)2.01190267
86Urticaria (HP:0001025)2.01144294
87Abnormality of the pericardium (HP:0001697)2.00032990
88Abnormality of the prostate (HP:0008775)1.99932171
89Amaurosis fugax (HP:0100576)1.99008635
90Chronic sinusitis (HP:0011109)1.98243595
91Frequent falls (HP:0002359)1.97100700
92Aplasia/Hypoplasia of the thymus (HP:0010515)1.93078742
93Anorexia (HP:0002039)1.92374603
94Keratitis (HP:0000491)1.91816771
95Hypoalbuminemia (HP:0003073)1.90815015
96Abnormal albumin level (HP:0012116)1.90815015
97Increased IgE level (HP:0003212)1.90697882
98Spontaneous hematomas (HP:0007420)1.90070692
99Pulmonary embolism (HP:0002204)1.89827161
100Keratoconjunctivitis (HP:0001096)1.88708740
1013-Methylglutaconic aciduria (HP:0003535)1.87213090
102Ureteral stenosis (HP:0000071)1.86449343
103Epistaxis (HP:0000421)1.82920930
104Gastrointestinal stroma tumor (HP:0100723)1.79383115
105Abnormality of male internal genitalia (HP:0000022)1.78290351
106Arthralgia (HP:0002829)1.77852551
107Cheilitis (HP:0100825)1.76169317
108Skin ulcer (HP:0200042)1.75748374
109Acrocyanosis (HP:0001063)1.75597146
110Alveolar cell carcinoma (HP:0006519)1.74898523
111Papilloma (HP:0012740)1.73630025
112Verrucae (HP:0200043)1.73630025
113Microcytic anemia (HP:0001935)1.73518477
114Abnormality of binocular vision (HP:0011514)1.73114146
115Diplopia (HP:0000651)1.73114146
116Emphysema (HP:0002097)1.72915928
117Bronchiectasis (HP:0002110)1.70954761
118Sepsis (HP:0100806)1.70662387
119Persistence of primary teeth (HP:0006335)1.70662272
120Pancytopenia (HP:0001876)1.69389474
121Cellular immunodeficiency (HP:0005374)1.67681382
122Premature graying of hair (HP:0002216)1.67593832
123Aplastic anemia (HP:0001915)1.66455662
124Restrictive lung disease (HP:0002091)1.64893358
125Oral leukoplakia (HP:0002745)1.64824292
126Polyneuropathy (HP:0001271)1.64637320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.81901197
2MAP4K15.89995171
3ZAP704.11394573
4TESK23.70995946
5KDR3.38241208
6ITK3.13722518
7JAK33.07138421
8FGFR43.03143287
9IKBKE2.59965124
10STK102.22891663
11LCK2.17993747
12MAP3K122.15968592
13TYK22.15467267
14RIPK42.10443837
15TAOK32.08461549
16MAP3K141.96976658
17NLK1.88385651
18JAK11.86106083
19NME21.79430695
20TESK11.65764652
21TEC1.57933155
22GRK61.57757690
23FGFR31.56822155
24TBK11.53669419
25BLK1.46662285
26CSK1.44380448
27SYK1.37613782
28PRKCQ1.35834065
29CAMKK21.34717099
30HCK1.22883550
31MST41.15927659
32BTK1.15705440
33EIF2AK11.13884136
34PRKCH1.07112198
35CAMKK11.02331497
36CLK10.99659735
37GRK70.96322489
38ADRBK20.91513896
39LYN0.89646283
40LRRK20.89518674
41IKBKB0.88880316
42TSSK60.88694802
43BCKDK0.86970606
44FGFR10.84418257
45SIK30.82600682
46KIT0.77940770
47LIMK10.76465342
48IRAK40.73571931
49SIK20.73515268
50EPHA30.70951725
51JAK20.70180823
52CHUK0.68294706
53MARK30.67171397
54RPS6KA40.66414435
55MAPKAPK30.65964911
56BUB10.65457182
57TNK20.61653082
58MAP3K130.60974036
59PRPF4B0.60764621
60SCYL20.58880065
61EEF2K0.58785263
62FYN0.58398208
63INSR0.57807656
64MAP3K100.56589244
65PIK3CG0.55834089
66MAP2K60.54375989
67TLK10.52702927
68MAP3K70.51165208
69PIM10.49160044
70ERN10.48986339
71MYLK0.48752073
72PIM20.48589969
73FES0.48335564
74MAP3K30.47409832
75MAPKAPK20.45649055
76TRIB30.44877440
77ALK0.44743024
78MATK0.44679658
79MAP3K110.43119858
80PKN20.43115807
81SIK10.42940584
82EIF2AK30.42694251
83MUSK0.42098603
84IGF1R0.41502659
85SRPK10.39348970
86PDGFRB0.39129278
87CSF1R0.38912960
88RAF10.38790134
89MAPK120.38180342
90PASK0.37255210
91TGFBR20.37061543
92ZAK0.36263668
93TAOK20.36077876
94NUAK10.34447288
95TYRO30.34269337
96VRK10.33879992
97BMPR20.33733739
98ILK0.33244043
99EPHB10.32280191
100PDK10.32267644
101CDC70.32185048
102MAP3K10.32059581
103IRAK10.31969017
104PIK3CA0.31583052
105MARK20.31503127
106FGR0.31481450
107MAP2K30.30250455
108NEK60.29476603
109TAOK10.28825728
110CDK40.25739823
111MAPK110.23968437
112DAPK10.23637729
113MAP3K80.22755097
114SRC0.20991386
115ABL10.20967925
116HIPK20.20804598
117STK40.19397445
118MAPK30.18638122
119PRKCD0.18520999
120TTN0.18167954
121VRK20.17734493
122PRKD20.15681962
123RPS6KA50.15584948
124ROCK20.14379084
125EGFR0.12778049
126AURKB0.12081728
127TGFBR10.11139761
128CDK120.10378369

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.79365341
2T cell receptor signaling pathway_Homo sapiens_hsa046604.24634838
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.48905513
4Allograft rejection_Homo sapiens_hsa053303.47122528
5Graft-versus-host disease_Homo sapiens_hsa053323.27085045
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.03747416
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.02341739
8Antigen processing and presentation_Homo sapiens_hsa046122.94063774
9Measles_Homo sapiens_hsa051622.92496995
10Autoimmune thyroid disease_Homo sapiens_hsa053202.63212404
11Viral myocarditis_Homo sapiens_hsa054162.54941143
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.52163541
13Hematopoietic cell lineage_Homo sapiens_hsa046402.32016850
14Leishmaniasis_Homo sapiens_hsa051401.70272824
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69913768
16Asthma_Homo sapiens_hsa053101.64191426
17Ribosome_Homo sapiens_hsa030101.55052634
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51597621
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.49529627
20Osteoclast differentiation_Homo sapiens_hsa043801.47958940
21Proteasome_Homo sapiens_hsa030501.46023037
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42278455
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39640804
24Herpes simplex infection_Homo sapiens_hsa051681.38556552
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32655488
26Type I diabetes mellitus_Homo sapiens_hsa049401.30006723
27B cell receptor signaling pathway_Homo sapiens_hsa046621.25664492
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25464370
29Shigellosis_Homo sapiens_hsa051311.23412151
30Spliceosome_Homo sapiens_hsa030401.19212707
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17145640
32Toxoplasmosis_Homo sapiens_hsa051451.13366085
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.12063995
34HTLV-I infection_Homo sapiens_hsa051661.10986832
35Chemokine signaling pathway_Homo sapiens_hsa040621.10551539
36Hepatitis B_Homo sapiens_hsa051611.02120922
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00431596
38DNA replication_Homo sapiens_hsa030300.95255352
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95203780
40Legionellosis_Homo sapiens_hsa051340.93516389
41Malaria_Homo sapiens_hsa051440.90731669
42Apoptosis_Homo sapiens_hsa042100.83784211
43Acute myeloid leukemia_Homo sapiens_hsa052210.81196127
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79628840
45Pancreatic cancer_Homo sapiens_hsa052120.79206707
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78835987
47Epstein-Barr virus infection_Homo sapiens_hsa051690.77712466
48VEGF signaling pathway_Homo sapiens_hsa043700.77096732
49Influenza A_Homo sapiens_hsa051640.75884810
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74147905
51p53 signaling pathway_Homo sapiens_hsa041150.72448578
52Colorectal cancer_Homo sapiens_hsa052100.72246174
53Mismatch repair_Homo sapiens_hsa034300.71044479
54Viral carcinogenesis_Homo sapiens_hsa052030.68417138
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66889814
56RNA degradation_Homo sapiens_hsa030180.66435533
57TNF signaling pathway_Homo sapiens_hsa046680.65140511
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63965638
59Salmonella infection_Homo sapiens_hsa051320.63877499
60African trypanosomiasis_Homo sapiens_hsa051430.63188533
61Staphylococcus aureus infection_Homo sapiens_hsa051500.57748795
62Nucleotide excision repair_Homo sapiens_hsa034200.57102239
63Prolactin signaling pathway_Homo sapiens_hsa049170.54761617
64Base excision repair_Homo sapiens_hsa034100.52813247
65Platelet activation_Homo sapiens_hsa046110.49748452
66Non-homologous end-joining_Homo sapiens_hsa034500.49163464
67Hepatitis C_Homo sapiens_hsa051600.48655843
68Tuberculosis_Homo sapiens_hsa051520.47716658
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43454082
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43208182
71RNA transport_Homo sapiens_hsa030130.41831425
72Endocytosis_Homo sapiens_hsa041440.40185760
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39971178
74Pertussis_Homo sapiens_hsa051330.37238908
75mRNA surveillance pathway_Homo sapiens_hsa030150.36442419
76Chronic myeloid leukemia_Homo sapiens_hsa052200.35746788
77RNA polymerase_Homo sapiens_hsa030200.35718398
78Pentose phosphate pathway_Homo sapiens_hsa000300.35355640
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35046989
80Regulation of autophagy_Homo sapiens_hsa041400.34706083
81Oxidative phosphorylation_Homo sapiens_hsa001900.34070174
82Phagosome_Homo sapiens_hsa041450.31523928
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30579454
84Rheumatoid arthritis_Homo sapiens_hsa053230.29645344
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28856446
86Homologous recombination_Homo sapiens_hsa034400.28504931
87Protein export_Homo sapiens_hsa030600.26440051
88Thyroid cancer_Homo sapiens_hsa052160.25931539
89Prion diseases_Homo sapiens_hsa050200.25863237
90Adherens junction_Homo sapiens_hsa045200.25843925
91Phototransduction_Homo sapiens_hsa047440.25684302
92Parkinsons disease_Homo sapiens_hsa050120.25419746
93Pyrimidine metabolism_Homo sapiens_hsa002400.24805899
94Linoleic acid metabolism_Homo sapiens_hsa005910.24690457
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24410675
96Rap1 signaling pathway_Homo sapiens_hsa040150.22148308
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19085997
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.18379062
99Cell cycle_Homo sapiens_hsa041100.18088301
100MAPK signaling pathway_Homo sapiens_hsa040100.16011899
101One carbon pool by folate_Homo sapiens_hsa006700.15598970
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.14811065
103Small cell lung cancer_Homo sapiens_hsa052220.14274736
104Ras signaling pathway_Homo sapiens_hsa040140.13870799
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13652511
106Collecting duct acid secretion_Homo sapiens_hsa049660.12752496
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.11697515
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10887071
109Basal transcription factors_Homo sapiens_hsa030220.09639285
110Nitrogen metabolism_Homo sapiens_hsa009100.09234251
111Caffeine metabolism_Homo sapiens_hsa002320.08891593
112Alzheimers disease_Homo sapiens_hsa050100.08066603
113Insulin resistance_Homo sapiens_hsa049310.05665054
114Systemic lupus erythematosus_Homo sapiens_hsa053220.05467907
115Pathways in cancer_Homo sapiens_hsa052000.04240232
116Olfactory transduction_Homo sapiens_hsa047400.04205677
117Other glycan degradation_Homo sapiens_hsa005110.04075558
118Notch signaling pathway_Homo sapiens_hsa043300.03221041
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03011164
120FoxO signaling pathway_Homo sapiens_hsa040680.02535105
121Non-small cell lung cancer_Homo sapiens_hsa052230.02513161
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02269528
123Sulfur relay system_Homo sapiens_hsa041220.01038265
124Lysosome_Homo sapiens_hsa041420.00336365
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.00305920
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0132340

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