TRAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.70838984
2antigen processing and presentation of endogenous antigen (GO:0019883)5.99378838
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81037337
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81037337
5positive regulation of gamma-delta T cell activation (GO:0046645)5.79454148
6regulation of vitamin D biosynthetic process (GO:0060556)5.62961424
7regulation of interleukin-12 biosynthetic process (GO:0045075)5.22370702
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.02152021
9negative thymic T cell selection (GO:0045060)4.97455520
10negative T cell selection (GO:0043383)4.93097434
11negative regulation of interleukin-12 production (GO:0032695)4.76913217
12response to muramyl dipeptide (GO:0032495)4.58684575
13regulation of vitamin metabolic process (GO:0030656)4.44136614
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34145221
15negative regulation of cell killing (GO:0031342)4.34145221
16T cell migration (GO:0072678)4.31085228
17regulation of cytokine secretion involved in immune response (GO:0002739)4.27997177
18myeloid dendritic cell differentiation (GO:0043011)4.25137389
19regulation of gamma-delta T cell activation (GO:0046643)4.24966965
20regulation of gamma-delta T cell differentiation (GO:0045586)4.24380216
21tolerance induction (GO:0002507)4.18553337
22regulation of dendritic cell antigen processing and presentation (GO:0002604)4.12748531
23positive regulation of heat generation (GO:0031652)4.08303221
24regulation of fever generation (GO:0031620)4.04434835
25positive regulation of humoral immune response (GO:0002922)4.04150061
26myeloid dendritic cell activation (GO:0001773)4.02583334
27positive thymic T cell selection (GO:0045059)4.01971389
28positive regulation of interleukin-2 production (GO:0032743)4.01803213
29response to interleukin-15 (GO:0070672)4.01085839
30regulation of alpha-beta T cell proliferation (GO:0046640)3.98088544
31response to protozoan (GO:0001562)3.94467865
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94216439
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.94019958
34CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.93641178
35cellular response to interleukin-15 (GO:0071350)3.93274432
36regulation of T cell tolerance induction (GO:0002664)3.90381120
37regulation of podosome assembly (GO:0071801)3.90284606
38T-helper 1 type immune response (GO:0042088)3.89538287
39thymic T cell selection (GO:0045061)3.87663671
40positive regulation of chemokine biosynthetic process (GO:0045080)3.85422713
41positive regulation of antigen processing and presentation (GO:0002579)3.85265175
42positive regulation of interleukin-12 production (GO:0032735)3.83344120
43response to type I interferon (GO:0034340)3.81887915
44cellular response to type I interferon (GO:0071357)3.81539804
45type I interferon signaling pathway (GO:0060337)3.81539804
46regulation of isotype switching to IgG isotypes (GO:0048302)3.81137195
47interferon-gamma-mediated signaling pathway (GO:0060333)3.78870221
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.78609816
49T cell selection (GO:0045058)3.76297444
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74449713
51CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.70349442
52T-helper cell differentiation (GO:0042093)3.70349442
53macrophage activation involved in immune response (GO:0002281)3.69001666
54interferon-gamma production (GO:0032609)3.68937919
55regulation of B cell receptor signaling pathway (GO:0050855)3.67629365
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.66959133
57regulation of interleukin-2 biosynthetic process (GO:0045076)3.65290361
58regulation of chemokine biosynthetic process (GO:0045073)3.61818579
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.60241365
60positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.59767393
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59000636
62negative regulation of cytokine production involved in immune response (GO:0002719)3.56774013
63positive regulation of natural killer cell differentiation (GO:0032825)3.56008212
64positive regulation of type 2 immune response (GO:0002830)3.55980678
65regulation of T-helper 1 cell differentiation (GO:0045625)3.55241331
66regulation of T-helper cell differentiation (GO:0045622)3.54690043
67leukocyte aggregation (GO:0070486)3.50352021
68regulation of chronic inflammatory response (GO:0002676)3.48157973
69regulation of RIG-I signaling pathway (GO:0039535)3.47222476
70positive T cell selection (GO:0043368)3.46815530
71neutrophil activation involved in immune response (GO:0002283)3.45395946
72T cell differentiation involved in immune response (GO:0002292)3.43246511
73alpha-beta T cell differentiation involved in immune response (GO:0002293)3.43246511
74alpha-beta T cell activation involved in immune response (GO:0002287)3.43246511
75mature B cell differentiation (GO:0002335)3.39447982
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.38778593
77positive regulation of isotype switching (GO:0045830)3.38515110
78regulation of antigen processing and presentation (GO:0002577)3.38298400
79regulation of interleukin-12 production (GO:0032655)3.38154310
80growth hormone receptor signaling pathway (GO:0060396)3.36536283
81positive regulation of T cell cytokine production (GO:0002726)3.36399362
82positive regulation of interferon-alpha production (GO:0032727)3.35174476
83natural killer cell mediated cytotoxicity (GO:0042267)3.34448030
84natural killer cell mediated immunity (GO:0002228)3.34448030
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.31571873
86positive regulation of NF-kappaB import into nucleus (GO:0042346)3.30489044
87regulation of interferon-beta biosynthetic process (GO:0045357)3.30087921
88positive regulation of T-helper cell differentiation (GO:0045624)3.29315463
89T cell activation involved in immune response (GO:0002286)3.26726705
90regulation of tolerance induction (GO:0002643)3.26590274
91positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.26490575
92regulation of immunoglobulin secretion (GO:0051023)3.25583719
93regulation of interferon-gamma biosynthetic process (GO:0045072)3.25170970
94neutrophil activation (GO:0042119)3.24315987
95regulation of interferon-alpha production (GO:0032647)3.24302216
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23982079
97lymphocyte migration (GO:0072676)3.21567597
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19556590
99granulocyte activation (GO:0036230)3.19474997
100germinal center formation (GO:0002467)3.17165739
101dendritic cell differentiation (GO:0097028)3.14672255
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14635283
103regulation of response to interferon-gamma (GO:0060330)3.14355106
104activation of MAPKKK activity (GO:0000185)3.14051907
105regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.13836209
106cellular response to interferon-gamma (GO:0071346)3.13705039
107response to peptidoglycan (GO:0032494)3.12780160
108negative regulation of T cell mediated immunity (GO:0002710)3.11960566
109regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.11723189
110positive regulation of immunoglobulin mediated immune response (GO:0002891)3.10935445
111positive regulation of B cell mediated immunity (GO:0002714)3.10935445
112immunoglobulin mediated immune response (GO:0016064)3.10280880
113regulation of interleukin-2 production (GO:0032663)3.09995891
114alpha-beta T cell activation (GO:0046631)3.07769975
115negative regulation of viral genome replication (GO:0045071)3.07458294
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07162938
117positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.04877959
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04567337
119regulation of heat generation (GO:0031650)3.04468010
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.03778225
121T cell costimulation (GO:0031295)3.03121149
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02822631
123regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.01749174
124positive regulation of defense response to virus by host (GO:0002230)3.00476694
125natural killer cell activation (GO:0030101)2.99936577
126defense response to protozoan (GO:0042832)2.99843479
127modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98980932
128positive regulation by organism of defense response of other organism involved in symbiotic interact2.98980932
129modulation by symbiont of host immune response (GO:0052553)2.98980932
130positive regulation by symbiont of host defense response (GO:0052509)2.98980932
131modulation by symbiont of host defense response (GO:0052031)2.98980932
132modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98980932
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98852694
134positive regulation of interleukin-17 production (GO:0032740)2.98749306
135positive regulation of T-helper 1 type immune response (GO:0002827)2.98459834
136positive regulation of cytokine biosynthetic process (GO:0042108)2.98379158
137regulation of natural killer cell mediated immunity (GO:0002715)2.97662996
138negative regulation of myeloid cell apoptotic process (GO:0033033)2.97299819
139positive regulation of interleukin-10 production (GO:0032733)2.92419754
140negative regulation of growth of symbiont in host (GO:0044130)2.92085732
141negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.92085732
142modulation of growth of symbiont involved in interaction with host (GO:0044144)2.92085732
143regulation of growth of symbiont in host (GO:0044126)2.92085732
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91263593
145cellular response to lipopolysaccharide (GO:0071222)2.91213061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.94491832
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.44554581
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.25321827
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.18971980
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.82873660
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.75012636
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.96152633
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.53002289
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.52771496
10* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.39914858
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.24106948
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21939854
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.13548546
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09443447
15RUNX_20019798_ChIP-Seq_JUKART_Human3.06918510
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94968714
17* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88087749
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84979218
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80651920
20MYB_26560356_Chip-Seq_TH2_Human2.71274780
21* MAF_26560356_Chip-Seq_TH1_Human2.45894586
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42682089
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34868313
24MYB_26560356_Chip-Seq_TH1_Human2.26084973
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.19768978
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11170555
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08188142
28MYC_22102868_ChIP-Seq_BL_Human1.90067081
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.87933148
30* SPI1_23547873_ChIP-Seq_NB4_Human1.82961997
31GATA3_27048872_Chip-Seq_THYMUS_Human1.77659746
32VDR_24763502_ChIP-Seq_THP-1_Human1.76539655
33VDR_21846776_ChIP-Seq_THP-1_Human1.75998832
34UTX_26944678_Chip-Seq_JUKART_Human1.73786049
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72165796
36VDR_24787735_ChIP-Seq_THP-1_Human1.65002803
37SCL_19346495_ChIP-Seq_HPC-7_Human1.63787121
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.63183595
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62401948
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.60843771
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60144734
42MAF_26560356_Chip-Seq_TH2_Human1.58286018
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56490708
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54385043
45PU_27001747_Chip-Seq_BMDM_Mouse1.53541840
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49289238
47SPI1_23127762_ChIP-Seq_K562_Human1.46944762
48* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46524296
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37399317
50GATA3_26560356_Chip-Seq_TH2_Human1.36574295
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32319876
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30343894
53KDM2B_26808549_Chip-Seq_DND41_Human1.30154274
54* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28207583
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27410236
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.21266925
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20816241
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20109887
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18280252
60* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17780276
61LXR_22292898_ChIP-Seq_THP-1_Human1.17696024
62GATA1_22025678_ChIP-Seq_K562_Human1.10501757
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08625544
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06415032
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.03799844
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01968093
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01943248
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98077064
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97218008
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94338790
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91039458
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89766268
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89183572
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89114642
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.88543224
76* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87644348
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87169195
78TFEB_21752829_ChIP-Seq_HELA_Human0.83646520
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83076196
80* SMRT_27268052_Chip-Seq_Bcells_Human0.81337314
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81115918
82* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80391868
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79870907
84EGR1_19032775_ChIP-ChIP_M12_Human0.78970140
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76974826
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76221823
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.75961553
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75587602
89STAT1_20625510_ChIP-Seq_HELA_Human0.75387566
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.74433898
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73773811
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72590165
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72466818
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72466818
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.72232071
96* BCOR_27268052_Chip-Seq_Bcells_Human0.70930657
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.70648341
98* BCL6_27268052_Chip-Seq_Bcells_Human0.69882399
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69478190
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68838119
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68654514
102SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68653743
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68204008
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67432727
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66078872
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65798014
107GATA2_19941826_ChIP-Seq_K562_Human0.65326944
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65108007
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61895576
110* NCOR1_26117541_ChIP-Seq_K562_Human0.59017443
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58771332
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56933415
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56643916
114GATA1_19941826_ChIP-Seq_K562_Human0.55006027
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54860730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.63312248
2MP0000685_abnormal_immune_system3.96974319
3MP0005671_abnormal_response_to3.76411001
4MP0004510_myositis3.54344664
5MP0005387_immune_system_phenotype3.52862500
6MP0001790_abnormal_immune_system3.52862500
7MP0009785_altered_susceptibility_to3.43809026
8MP0001800_abnormal_humoral_immune3.26791582
9MP0005000_abnormal_immune_tolerance3.25461816
10MP0002138_abnormal_hepatobiliary_system3.25343163
11MP0003436_decreased_susceptibility_to3.14499219
12MP0002148_abnormal_hypersensitivity_rea3.00503795
13MP0002723_abnormal_immune_serum2.89422320
14MP0002452_abnormal_antigen_presenting2.88081992
15MP0003763_abnormal_thymus_physiology2.87869859
16MP0003303_peritoneal_inflammation2.74980887
17MP0005025_abnormal_response_to2.70943269
18MP0002166_altered_tumor_susceptibility2.66977834
19* MP0001819_abnormal_immune_cell2.63814584
20* MP0002420_abnormal_adaptive_immunity2.62620754
21MP0002419_abnormal_innate_immunity2.51520473
22MP0002006_tumorigenesis2.42685623
23MP0006082_CNS_inflammation2.39765784
24MP0003724_increased_susceptibility_to2.36229272
25MP0004947_skin_inflammation2.27129059
26MP0002405_respiratory_system_inflammati2.25839873
27MP0002254_reproductive_system_inflammat2.21328712
28MP0005451_abnormal_body_composition2.16090232
29* MP0002398_abnormal_bone_marrow2.14640968
30* MP0000716_abnormal_immune_system2.09281349
31MP0001873_stomach_inflammation2.07729848
32MP0010155_abnormal_intestine_physiology2.03200099
33MP0005310_abnormal_salivary_gland2.02243901
34MP0001853_heart_inflammation1.97241749
35MP0009333_abnormal_splenocyte_physiolog1.94585398
36MP0003300_gastrointestinal_ulcer1.86246331
37MP0001845_abnormal_inflammatory_respons1.77864373
38MP0002139_abnormal_hepatobiliary_system1.77576148
39MP0001348_abnormal_lacrimal_gland1.69894034
40MP0000689_abnormal_spleen_morphology1.65652239
41* MP0002429_abnormal_blood_cell1.64480012
42MP0008004_abnormal_stomach_pH1.63247266
43* MP0002722_abnormal_immune_system1.60849660
44MP0009840_abnormal_foam_cell1.57562374
45MP0001533_abnormal_skeleton_physiology1.51598322
46MP0002277_abnormal_respiratory_mucosa1.49823234
47MP0002332_abnormal_exercise_endurance1.49037916
48MP0003448_altered_tumor_morphology1.48864015
49MP0005464_abnormal_platelet_physiology1.48278569
50MP0000703_abnormal_thymus_morphology1.47744609
51MP0005167_abnormal_blood-brain_barrier1.45165476
52MP0002933_joint_inflammation1.42807334
53MP0002009_preneoplasia1.39337036
54MP0008469_abnormal_protein_level1.35139934
55MP0003866_abnormal_defecation1.32270787
56MP0009764_decreased_sensitivity_to1.28431796
57MP0002163_abnormal_gland_morphology1.26343022
58MP0000569_abnormal_digit_pigmentation1.22755638
59MP0000858_altered_metastatic_potential1.18040723
60MP0002998_abnormal_bone_remodeling1.15708453
61MP0005397_hematopoietic_system_phenotyp1.12510999
62MP0001545_abnormal_hematopoietic_system1.12510999
63MP0002396_abnormal_hematopoietic_system1.11376885
64MP0005076_abnormal_cell_differentiation1.09600140
65MP0003453_abnormal_keratinocyte_physiol1.07695421
66MP0010352_gastrointestinal_tract_polyps1.04944403
67MP0009278_abnormal_bone_marrow1.04406464
68MP0003091_abnormal_cell_migration1.03981629
69MP0003656_abnormal_erythrocyte_physiolo1.00288784
70MP0003690_abnormal_glial_cell0.99838489
71MP0000604_amyloidosis0.97702074
72MP0005058_abnormal_lysosome_morphology0.95245115
73MP0004808_abnormal_hematopoietic_stem0.94186363
74MP0002877_abnormal_melanocyte_morpholog0.93715326
75MP0001851_eye_inflammation0.90923456
76MP0006054_spinal_hemorrhage0.89250387
77MP0003172_abnormal_lysosome_physiology0.86214378
78MP0003195_calcinosis0.85653151
79MP0005174_abnormal_tail_pigmentation0.81810645
80MP0003806_abnormal_nucleotide_metabolis0.79256874
81MP0003045_fibrosis0.77817737
82MP0005164_abnormal_response_to0.75169057
83MP0001501_abnormal_sleep_pattern0.75117879
84MP0003191_abnormal_cellular_cholesterol0.74123298
85MP0008874_decreased_physiological_sensi0.73583870
86MP0008057_abnormal_DNA_replication0.72344172
87MP0009763_increased_sensitivity_to0.72084434
88MP0000490_abnormal_crypts_of0.69858977
89MP0001881_abnormal_mammary_gland0.69679520
90MP0003183_abnormal_peptide_metabolism0.67986247
91MP0000465_gastrointestinal_hemorrhage0.67781933
92MP0000249_abnormal_blood_vessel0.67564565
93MP0000343_altered_response_to0.66614770
94MP0003646_muscle_fatigue0.66448586
95MP0005165_increased_susceptibility_to0.65400587
96MP0003828_pulmonary_edema0.65147797
97MP0002136_abnormal_kidney_physiology0.64772327
98MP0005535_abnormal_body_temperature0.64150115
99MP0001346_abnormal_lacrimal_gland0.63922456
100MP0005390_skeleton_phenotype0.62085630
101MP0010307_abnormal_tumor_latency0.61935287
102MP0009765_abnormal_xenobiotic_induced0.61679908
103MP0000920_abnormal_myelination0.60788755
104MP0003075_altered_response_to0.59210797
105MP0002019_abnormal_tumor_incidence0.58480379
106MP0008260_abnormal_autophagy0.58422730
107MP0001542_abnormal_bone_strength0.58260336
108MP0001243_abnormal_dermal_layer0.57372019
109MP0005647_abnormal_sex_gland0.57297855
110MP0005166_decreased_susceptibility_to0.54505963
111MP0000627_abnormal_mammary_gland0.54240139
112MP0001191_abnormal_skin_condition0.53644059
113MP0000609_abnormal_liver_physiology0.53375030
114MP0000371_diluted_coat_color0.52940839
115MP0001216_abnormal_epidermal_layer0.52191126
116MP0001663_abnormal_digestive_system0.51196917
117MP0003795_abnormal_bone_structure0.50230976
118MP0005379_endocrine/exocrine_gland_phen0.49349798
119MP0004381_abnormal_hair_follicle0.49069987
120MP0000015_abnormal_ear_pigmentation0.47194288
121MP0004782_abnormal_surfactant_physiolog0.45201094
122MP0002693_abnormal_pancreas_physiology0.44521522
123MP0005023_abnormal_wound_healing0.41972838

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.61766299
2Elevated erythrocyte sedimentation rate (HP:0003565)5.60234148
3Stomatitis (HP:0010280)5.57417778
4Retrobulbar optic neuritis (HP:0100654)5.35671338
5Optic neuritis (HP:0100653)5.35671338
6Recurrent abscess formation (HP:0002722)5.13747627
7Myositis (HP:0100614)5.06503278
8Recurrent fungal infections (HP:0002841)4.90984111
9Orchitis (HP:0100796)4.87334011
10Chronic otitis media (HP:0000389)4.87281643
11Abnormality of glycolipid metabolism (HP:0010969)4.77901986
12Abnormality of liposaccharide metabolism (HP:0010968)4.77901986
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.77901986
14Recurrent bacterial skin infections (HP:0005406)4.74902811
15Recurrent viral infections (HP:0004429)4.59631419
16Mediastinal lymphadenopathy (HP:0100721)4.54342561
17Nasal polyposis (HP:0100582)4.40214174
18Increased IgM level (HP:0003496)4.24634767
19Vasculitis (HP:0002633)4.20674558
20Abnormality of T cell number (HP:0011839)4.13692483
21Recurrent bronchitis (HP:0002837)4.06454223
22Pulmonary infiltrates (HP:0002113)3.99475272
23T lymphocytopenia (HP:0005403)3.94084077
24Recurrent cutaneous fungal infections (HP:0011370)3.89141993
25Chronic mucocutaneous candidiasis (HP:0002728)3.89141993
26Gastrointestinal infarctions (HP:0005244)3.83427167
27Abnormality of the nasal mucosa (HP:0000433)3.78524949
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.72928528
29Recurrent skin infections (HP:0001581)3.64247059
30Loss of speech (HP:0002371)3.62133223
31Arterial thrombosis (HP:0004420)3.49530889
32Abnormality of macrophages (HP:0004311)3.46777859
33Autoimmune thrombocytopenia (HP:0001973)3.42348154
34Vacuolated lymphocytes (HP:0001922)3.38830105
35Abnormality of T cells (HP:0002843)3.35696739
36Leukocytosis (HP:0001974)3.35232747
37Panhypogammaglobulinemia (HP:0003139)3.34426542
38Agammaglobulinemia (HP:0004432)3.34152534
39Systemic lupus erythematosus (HP:0002725)3.34059708
40Keratoconjunctivitis sicca (HP:0001097)3.32011955
41Dysostosis multiplex (HP:0000943)3.28116032
42Meningitis (HP:0001287)3.27603631
43Recurrent gram-negative bacterial infections (HP:0005420)3.21880355
44Colitis (HP:0002583)3.19388936
45Increased IgE level (HP:0003212)3.18331824
46Keratoconjunctivitis (HP:0001096)3.15450571
47Hemoptysis (HP:0002105)3.14523782
48Eosinophilia (HP:0001880)3.13378792
49Obstructive lung disease (HP:0006536)3.13077532
50Chronic obstructive pulmonary disease (HP:0006510)3.13077532
51Disinhibition (HP:0000734)3.12502654
52Inflammation of the large intestine (HP:0002037)3.11859465
53Hypergammaglobulinemia (HP:0010702)3.07562097
54Interstitial pulmonary disease (HP:0006530)3.05883012
55Increased cerebral lipofuscin (HP:0011813)3.03074016
56Gingivitis (HP:0000230)3.01611431
57Chronic diarrhea (HP:0002028)3.00886717
58IgG deficiency (HP:0004315)3.00200946
59Abnormality of eosinophils (HP:0001879)2.95786806
60Chronic sinusitis (HP:0011109)2.92335954
61Gastrointestinal inflammation (HP:0004386)2.90782347
62Pustule (HP:0200039)2.90604919
63IgA deficiency (HP:0002720)2.84935805
64Severe combined immunodeficiency (HP:0004430)2.83444987
65Abnormality of T cell physiology (HP:0011840)2.80932724
66Joint swelling (HP:0001386)2.79139024
67IgM deficiency (HP:0002850)2.78970599
68Fatigue (HP:0012378)2.78301112
69Gastrointestinal stroma tumor (HP:0100723)2.77867097
70Encephalitis (HP:0002383)2.77796101
71Abnormality of the fingertips (HP:0001211)2.74935519
72Lymphopenia (HP:0001888)2.71846365
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.71163754
74Emphysema (HP:0002097)2.71046840
75Granulocytopenia (HP:0001913)2.70588894
76Combined immunodeficiency (HP:0005387)2.64780272
77Hematochezia (HP:0002573)2.63259255
78Periodontitis (HP:0000704)2.62028223
79Autoimmune hemolytic anemia (HP:0001890)2.60890524
80Thyroiditis (HP:0100646)2.54226902
81Abnormality of the pleura (HP:0002103)2.52780487
82Cellulitis (HP:0100658)2.52609424
83Thrombocytosis (HP:0001894)2.51598556
84Recurrent sinusitis (HP:0011108)2.51582554
85Myocardial infarction (HP:0001658)2.45473657
86Polyneuropathy (HP:0001271)2.43788051
87Mutism (HP:0002300)2.43413195
88Parakeratosis (HP:0001036)2.42796160
89Chest pain (HP:0100749)2.42507830
90Nuclear cataract (HP:0100018)2.41765684
91Increased serum ferritin (HP:0003281)2.41235229
92Gingival bleeding (HP:0000225)2.39194035
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.34568694
94Spontaneous hematomas (HP:0007420)2.32998204
95Bronchitis (HP:0012387)2.32406297
96Abnormality of polysaccharide metabolism (HP:0011012)2.31609773
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31609773
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31609773
99Persistence of primary teeth (HP:0006335)2.30201639
100Osteomyelitis (HP:0002754)2.25058452
101B lymphocytopenia (HP:0010976)2.23322577
102Abnormality of B cell number (HP:0010975)2.23322577
103Porencephaly (HP:0002132)2.22395193
104Urinary glycosaminoglycan excretion (HP:0003541)2.20904732
105Mucopolysacchariduria (HP:0008155)2.20904732
106Basal ganglia calcification (HP:0002135)2.17015468
107Arthralgia (HP:0002829)2.16358381
108Glomerulopathy (HP:0100820)2.14977372
109Anorexia (HP:0002039)2.14046642
110Apathy (HP:0000741)2.11819429
111Glomerulonephritis (HP:0000099)2.10609417
112Neurofibrillary tangles (HP:0002185)2.10395575
113Gangrene (HP:0100758)2.10076697
114Pulmonary embolism (HP:0002204)2.08575526
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08133318
116Tetraparesis (HP:0002273)2.05594333
117Premature loss of primary teeth (HP:0006323)2.05526941
118Prostate neoplasm (HP:0100787)2.05431949
119Recurrent pneumonia (HP:0006532)2.04453377
120Neuronal loss in central nervous system (HP:0002529)2.04245856
121Restrictive lung disease (HP:0002091)2.04010026
122Hypertensive crisis (HP:0100735)2.03786855
123Amaurosis fugax (HP:0100576)2.03556076
124Abnormality of the pericardium (HP:0001697)2.01656530
125Skin ulcer (HP:0200042)2.01458713
126Diminished motivation (HP:0000745)2.00900493
127Urticaria (HP:0001025)2.00767602
128Abnormality of the prostate (HP:0008775)1.98792841
129Recurrent lower respiratory tract infections (HP:0002783)1.95023442
130Peritonitis (HP:0002586)1.93177279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.32118707
2MAP4K13.97380642
3TYK23.71974824
4JAK33.63236787
5TXK3.59890207
6PRPF4B3.42475056
7TBK13.41355771
8MAP3K133.33126775
9IKBKE3.30234035
10IKBKB3.07708364
11JAK12.79284998
12TAOK22.66277825
13GRK72.52171964
14IRAK32.46426908
15IRAK42.41664064
16CHUK2.37089464
17BLK2.33761310
18FGFR42.28090484
19DDR22.23794735
20MATK2.21823802
21EPHB12.08963603
22RIPK41.94079491
23ITK1.87916969
24ZAP701.86294736
25EPHA31.78298635
26RIPK11.74718195
27TAOK11.67238390
28FGFR31.66118424
29KIT1.63427262
30MAP3K111.54469775
31CSK1.53276407
32STK101.50708009
33CDC42BPA1.50319758
34LCK1.45284822
35SYK1.42546715
36NLK1.38247754
37MOS1.35962248
38MST41.34455719
39TAOK31.28171759
40HCK1.26262960
41BTK1.23898877
42TEC1.23888600
43IRAK11.18735553
44PIM11.12758020
45JAK21.12682984
46GRK61.11828787
47RPS6KA41.11738103
48TYRO31.11368160
49CSF1R1.11293037
50SIK21.03313560
51SIK30.99995487
52PRKCQ0.96499023
53MARK30.93149131
54MAP3K100.82674812
55FES0.82187104
56PIM20.80670199
57LYN0.79820507
58ADRBK20.78926890
59FGR0.77697073
60NEK90.75726124
61LRRK20.71350396
62BMPR20.65239143
63CDK120.65105642
64PTK60.64865126
65SMG10.55302070
66EIF2AK20.52454690
67TRIB30.52306855
68PRKAA20.51275430
69RPS6KA50.50691302
70MAPK40.49946612
71MAP2K30.49070875
72MAPKAPK20.47865884
73MAPK70.46420161
74MAPK110.45262711
75ALK0.43112685
76STK40.42679801
77PDGFRA0.42535098
78FLT30.42252801
79EGFR0.41879104
80TNK20.41870303
81ABL10.41788504
82TGFBR20.41377545
83BMX0.40489340
84HIPK20.39708330
85CLK10.39622597
86PRKCD0.39264650
87ICK0.39189859
88MELK0.39009065
89IRAK20.38685954
90MAP3K70.37324159
91MAP2K60.35879752
92PDGFRB0.35829391
93ARAF0.35519638
94NUAK10.35079587
95INSR0.33315160
96PRKCH0.33260121
97RPS6KA10.33102251
98ERN10.31743296
99CAMKK20.27614793
100STK240.27229776
101RPS6KL10.26195908
102RPS6KC10.26195908
103FYN0.24774224
104TTN0.23809584
105RET0.23599486
106MARK20.22868893
107GSK3A0.22318361
108PDPK10.21568998
109MAP3K10.21474616
110SGK10.21244783
111MAP3K30.21056401
112PDK10.20698967
113PBK0.20561620
114CAMKK10.20549344
115IGF1R0.20471942
116MAP3K50.20380159
117TESK20.20024040
118NME20.19512006
119SIK10.19149178
120MAPK30.19120381
121PASK0.18398059
122RAF10.17479814
123CDK40.17218019
124BRD40.14964620
125TRPM70.13405993
126CDK90.13260259
127TGFBR10.13059556
128MAP3K80.13052145
129CDK60.12975354
130STK110.12965094

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.44675845
2Graft-versus-host disease_Homo sapiens_hsa053323.39861759
3* NF-kappa B signaling pathway_Homo sapiens_hsa040643.22394705
4Primary immunodeficiency_Homo sapiens_hsa053403.02118942
5Leishmaniasis_Homo sapiens_hsa051402.86304724
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.80694414
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.71772387
8Measles_Homo sapiens_hsa051622.70531162
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.45658531
10Osteoclast differentiation_Homo sapiens_hsa043802.44241966
11T cell receptor signaling pathway_Homo sapiens_hsa046602.28371210
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23036289
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23009758
14Autoimmune thyroid disease_Homo sapiens_hsa053202.13250074
15Antigen processing and presentation_Homo sapiens_hsa046122.11375175
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05457152
17B cell receptor signaling pathway_Homo sapiens_hsa046622.02929648
18* TNF signaling pathway_Homo sapiens_hsa046682.00797290
19Type I diabetes mellitus_Homo sapiens_hsa049401.97844552
20Toxoplasmosis_Homo sapiens_hsa051451.90959630
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.86051165
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84379105
23Influenza A_Homo sapiens_hsa051641.75425714
24Other glycan degradation_Homo sapiens_hsa005111.74638194
25Legionellosis_Homo sapiens_hsa051341.73743323
26* Herpes simplex infection_Homo sapiens_hsa051681.64174538
27Chemokine signaling pathway_Homo sapiens_hsa040621.60754545
28Asthma_Homo sapiens_hsa053101.58413589
29Malaria_Homo sapiens_hsa051441.57387691
30Hematopoietic cell lineage_Homo sapiens_hsa046401.54615109
31Viral myocarditis_Homo sapiens_hsa054161.49292818
32Tuberculosis_Homo sapiens_hsa051521.49292338
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45851760
34Pertussis_Homo sapiens_hsa051331.40951361
35* Apoptosis_Homo sapiens_hsa042101.39817644
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34590846
37Shigellosis_Homo sapiens_hsa051311.31551020
38Rheumatoid arthritis_Homo sapiens_hsa053231.31380475
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26171125
40Hepatitis B_Homo sapiens_hsa051611.25008480
41Acute myeloid leukemia_Homo sapiens_hsa052211.23865299
42African trypanosomiasis_Homo sapiens_hsa051431.22095748
43Staphylococcus aureus infection_Homo sapiens_hsa051501.21950346
44Hepatitis C_Homo sapiens_hsa051601.15028878
45Salmonella infection_Homo sapiens_hsa051321.12034126
46Prolactin signaling pathway_Homo sapiens_hsa049171.11703112
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03488998
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00903937
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.96023794
50Prion diseases_Homo sapiens_hsa050200.95797292
51* Epstein-Barr virus infection_Homo sapiens_hsa051690.95721600
52Chronic myeloid leukemia_Homo sapiens_hsa052200.92283371
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89418050
54Pancreatic cancer_Homo sapiens_hsa052120.83163614
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77135379
56HTLV-I infection_Homo sapiens_hsa051660.75780513
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.75570685
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.75191184
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.72741371
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71349992
61* Small cell lung cancer_Homo sapiens_hsa052220.69034988
62* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68076858
63Bladder cancer_Homo sapiens_hsa052190.66390932
64* Viral carcinogenesis_Homo sapiens_hsa052030.63159055
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60181497
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60113618
67VEGF signaling pathway_Homo sapiens_hsa043700.57973278
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57581380
69MAPK signaling pathway_Homo sapiens_hsa040100.57224385
70Platelet activation_Homo sapiens_hsa046110.55928429
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55027660
72Systemic lupus erythematosus_Homo sapiens_hsa053220.51914012
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49871353
74Amoebiasis_Homo sapiens_hsa051460.49654814
75p53 signaling pathway_Homo sapiens_hsa041150.48849982
76Type II diabetes mellitus_Homo sapiens_hsa049300.45064543
77Insulin resistance_Homo sapiens_hsa049310.44048993
78HIF-1 signaling pathway_Homo sapiens_hsa040660.41142198
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.41124592
80MicroRNAs in cancer_Homo sapiens_hsa052060.40263593
81Notch signaling pathway_Homo sapiens_hsa043300.39095933
82Phagosome_Homo sapiens_hsa041450.38517900
83FoxO signaling pathway_Homo sapiens_hsa040680.38260030
84Lysosome_Homo sapiens_hsa041420.37442296
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35871374
86Endocytosis_Homo sapiens_hsa041440.33119068
87Dorso-ventral axis formation_Homo sapiens_hsa043200.30984449
88Colorectal cancer_Homo sapiens_hsa052100.30290896
89Prostate cancer_Homo sapiens_hsa052150.30183538
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28970793
91Sphingolipid metabolism_Homo sapiens_hsa006000.28600735
92Renal cell carcinoma_Homo sapiens_hsa052110.28427876
93Non-small cell lung cancer_Homo sapiens_hsa052230.26112259
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24256917
95Inositol phosphate metabolism_Homo sapiens_hsa005620.23400790
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22231552
97Proteoglycans in cancer_Homo sapiens_hsa052050.21467732
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19305655
99* Pathways in cancer_Homo sapiens_hsa052000.19266499
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19167223
101mTOR signaling pathway_Homo sapiens_hsa041500.19081143
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17773921
103Complement and coagulation cascades_Homo sapiens_hsa046100.15466228
104Ras signaling pathway_Homo sapiens_hsa040140.13514876
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13406248
106GnRH signaling pathway_Homo sapiens_hsa049120.12972438
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.12360732
108Choline metabolism in cancer_Homo sapiens_hsa052310.10747498
109ErbB signaling pathway_Homo sapiens_hsa040120.10639105
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09282901
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07935664
112Collecting duct acid secretion_Homo sapiens_hsa049660.05226929
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04876158

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