TRAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.74490187
2proteasome assembly (GO:0043248)5.23672659
3mitotic chromosome condensation (GO:0007076)4.77399626
4viral transcription (GO:0019083)4.44034720
5DNA deamination (GO:0045006)4.41013635
6central nervous system myelination (GO:0022010)4.40136992
7axon ensheathment in central nervous system (GO:0032291)4.40136992
8maturation of SSU-rRNA (GO:0030490)4.33567358
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.25526961
10termination of RNA polymerase III transcription (GO:0006386)4.25526961
11DNA unwinding involved in DNA replication (GO:0006268)4.25113111
12ribosomal large subunit biogenesis (GO:0042273)4.24829587
13translational termination (GO:0006415)4.24504444
14ribosomal small subunit assembly (GO:0000028)4.19044605
15spliceosomal tri-snRNP complex assembly (GO:0000244)3.94106990
16rRNA modification (GO:0000154)3.81445691
17cotranslational protein targeting to membrane (GO:0006613)3.77937400
18NIK/NF-kappaB signaling (GO:0038061)3.75395311
19DNA synthesis involved in DNA repair (GO:0000731)3.75336245
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.73678054
21protein targeting to ER (GO:0045047)3.71145524
227-methylguanosine mRNA capping (GO:0006370)3.70987244
23meiotic chromosome segregation (GO:0045132)3.65314871
247-methylguanosine RNA capping (GO:0009452)3.65301053
25RNA capping (GO:0036260)3.65301053
26chaperone-mediated protein transport (GO:0072321)3.60738121
27mitotic sister chromatid segregation (GO:0000070)3.58845839
28protein neddylation (GO:0045116)3.54454935
29synapsis (GO:0007129)3.53714022
30protein localization to endoplasmic reticulum (GO:0070972)3.53295552
31chromosome organization involved in meiosis (GO:0070192)3.53290707
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52724470
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51479542
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49463386
35rRNA transcription (GO:0009303)3.48237552
36translational elongation (GO:0006414)3.45929596
37ribonucleoprotein complex biogenesis (GO:0022613)3.44848840
38transcription elongation from RNA polymerase I promoter (GO:0006362)3.44815517
39telomere maintenance via semi-conservative replication (GO:0032201)3.43235439
40DNA damage response, detection of DNA damage (GO:0042769)3.42845896
41synaptonemal complex assembly (GO:0007130)3.38588429
42viral life cycle (GO:0019058)3.37177051
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37005045
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36483657
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34881809
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.34593771
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32157017
48nuclear pore complex assembly (GO:0051292)3.30856961
49cellular protein complex disassembly (GO:0043624)3.29296812
50translational initiation (GO:0006413)3.28197883
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27610679
52negative regulation of ligase activity (GO:0051352)3.27610679
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27029363
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26010163
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26010163
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26010163
57establishment of integrated proviral latency (GO:0075713)3.25154923
58translation (GO:0006412)3.25046177
59termination of RNA polymerase I transcription (GO:0006363)3.24721316
60ATP synthesis coupled proton transport (GO:0015986)3.23784357
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23784357
62GTP biosynthetic process (GO:0006183)3.23743390
63regulation of cellular amino acid metabolic process (GO:0006521)3.23723267
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21228316
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.20738248
66transcription-coupled nucleotide-excision repair (GO:0006283)3.20311932
67mitotic nuclear envelope disassembly (GO:0007077)3.20251442
68deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.19422189
69rRNA processing (GO:0006364)3.18045485
70RNA destabilization (GO:0050779)3.18026876
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.16682886
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16682886
73transcription from RNA polymerase I promoter (GO:0006360)3.16329701
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16262532
75metallo-sulfur cluster assembly (GO:0031163)3.15060358
76iron-sulfur cluster assembly (GO:0016226)3.15060358
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.14397251
78formation of translation preinitiation complex (GO:0001731)3.14294478
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14209150
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14209150
81rRNA methylation (GO:0031167)3.13948753
82male meiosis I (GO:0007141)3.13891916
83mitotic recombination (GO:0006312)3.13666855
84establishment of viral latency (GO:0019043)3.12778161
85protein localization to chromosome, centromeric region (GO:0071459)3.12411560
86peptidyl-arginine omega-N-methylation (GO:0035247)3.12329386
87DNA strand elongation involved in DNA replication (GO:0006271)3.09753053
88sister chromatid segregation (GO:0000819)3.08275564
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07480884
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05852709
91GDP-mannose metabolic process (GO:0019673)3.05097573
92spliceosomal snRNP assembly (GO:0000387)3.05050798
93rRNA metabolic process (GO:0016072)3.04112114
94pore complex assembly (GO:0046931)3.02689748
95deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.02646148
96telomere maintenance via recombination (GO:0000722)3.02426732
97ribosome assembly (GO:0042255)3.01728391
98meiosis I (GO:0007127)3.01405835
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01155952
100piRNA metabolic process (GO:0034587)3.00172392
101pseudouridine synthesis (GO:0001522)2.97191501
102RNA methylation (GO:0001510)2.96785145
103spliceosomal complex assembly (GO:0000245)2.95254243
104DNA strand elongation (GO:0022616)2.94871850
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94521545
106GPI anchor biosynthetic process (GO:0006506)2.94126005
107membrane disassembly (GO:0030397)2.93847468
108nuclear envelope disassembly (GO:0051081)2.93847468
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.93310269
110tRNA methylation (GO:0030488)2.92444607
111DNA replication initiation (GO:0006270)2.91430418
112cellular component biogenesis (GO:0044085)2.90209465
113deoxyribonucleotide biosynthetic process (GO:0009263)2.89190221
114protein maturation by protein folding (GO:0022417)2.88427733
115meiotic nuclear division (GO:0007126)2.87668460
116peptidyl-histidine modification (GO:0018202)2.86894013
117protein localization to kinetochore (GO:0034501)2.84258833
118protein-cofactor linkage (GO:0018065)2.83744990
119DNA replication checkpoint (GO:0000076)2.83163497
120Golgi transport vesicle coating (GO:0048200)2.82792061
121COPI coating of Golgi vesicle (GO:0048205)2.82792061
122chromosome condensation (GO:0030261)2.81187021
123CENP-A containing nucleosome assembly (GO:0034080)2.79250999
124synaptonemal complex organization (GO:0070193)2.78875680
125positive regulation of viral transcription (GO:0050434)2.77120798
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76553280
127positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.75834288
128ncRNA 3-end processing (GO:0043628)2.74209482
129nuclear pore organization (GO:0006999)2.73621761
130protein complex disassembly (GO:0043241)2.73069047
131keratinocyte development (GO:0003334)2.72918306
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72873595
133UTP biosynthetic process (GO:0006228)2.72372316
134regulation of translational termination (GO:0006449)2.71383362
135folic acid metabolic process (GO:0046655)2.70875451
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.69092932
137nucleobase biosynthetic process (GO:0046112)2.68172660
138telomere maintenance via telomere lengthening (GO:0010833)2.67817896
139glycerophospholipid catabolic process (GO:0046475)2.67151214
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66683247
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66552485
142mitotic metaphase plate congression (GO:0007080)2.65490338
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65449092
144regulation of mitochondrial translation (GO:0070129)2.65134304
145base-excision repair (GO:0006284)2.64955197
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64873105
147transcription from mitochondrial promoter (GO:0006390)2.64587907
148ribosome biogenesis (GO:0042254)2.63990600
149protein targeting to mitochondrion (GO:0006626)2.63755355
150DNA methylation involved in gamete generation (GO:0043046)2.59514976
151histone arginine methylation (GO:0034969)2.57992325
152nucleotide salvage (GO:0043173)2.57954822
153negative regulation of DNA-templated transcription, elongation (GO:0032785)2.56938363
154chromosome segregation (GO:0007059)2.55217960
155DNA biosynthetic process (GO:0071897)2.55199365
156purine nucleobase biosynthetic process (GO:0009113)2.54665147
157proline biosynthetic process (GO:0006561)2.52804996
158DNA packaging (GO:0006323)2.52360822
159pentose metabolic process (GO:0019321)2.50921272
160nuclear envelope organization (GO:0006998)2.49424795
161positive regulation of chromosome segregation (GO:0051984)2.49043149
162negative regulation of chromosome segregation (GO:0051985)2.48980992
163viral mRNA export from host cell nucleus (GO:0046784)2.47605371
164nuclear envelope reassembly (GO:0031468)2.46430111
165mitotic nuclear envelope reassembly (GO:0007084)2.46430111
166DNA replication-dependent nucleosome assembly (GO:0006335)2.46251706
167DNA replication-dependent nucleosome organization (GO:0034723)2.46251706
168chromatin assembly (GO:0031497)2.46135641
169heterochromatin organization (GO:0070828)2.45548791
170protein localization to chromosome (GO:0034502)2.44130342
171meiotic cell cycle process (GO:1903046)2.42691678
172mitochondrial RNA metabolic process (GO:0000959)2.42527589
173mitochondrial DNA metabolic process (GO:0032042)2.42463444
174regulation of translational fidelity (GO:0006450)2.42076093
175IMP biosynthetic process (GO:0006188)2.40677258
176regulation of transcription from RNA polymerase I promoter (GO:0006356)2.39884383
177mitotic spindle assembly checkpoint (GO:0007094)2.39181828
178chaperone mediated protein folding requiring cofactor (GO:0051085)2.38658157
179DNA duplex unwinding (GO:0032508)2.38346751
180L-serine metabolic process (GO:0006563)2.37664426
181male meiosis (GO:0007140)2.36882817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.05569965
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60166969
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.12618918
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.12272125
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.08158344
6* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.02800807
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.85868857
8E2F7_22180533_ChIP-Seq_HELA_Human3.70579493
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68784767
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.49234424
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.34840289
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07469680
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.95865793
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74732295
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62324840
16VDR_23849224_ChIP-Seq_CD4+_Human2.62228264
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51825217
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51744242
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.50131730
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49147795
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40739783
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40328359
23MYC_22102868_ChIP-Seq_BL_Human2.31843499
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31410058
25VDR_21846776_ChIP-Seq_THP-1_Human2.29208374
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26090133
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.16402095
28ELK1_19687146_ChIP-ChIP_HELA_Human2.11199170
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.08981765
30FOXP3_21729870_ChIP-Seq_TREG_Human2.05160681
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03061828
32DCP1A_22483619_ChIP-Seq_HELA_Human1.95392476
33XRN2_22483619_ChIP-Seq_HELA_Human1.89045230
34TTF2_22483619_ChIP-Seq_HELA_Human1.87330786
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85859645
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85160094
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76448166
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75512227
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74148305
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73444605
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71026891
42IRF1_19129219_ChIP-ChIP_H3396_Human1.66135920
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.65756274
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63976875
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63836461
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63259957
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60995742
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60880703
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59388667
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57694788
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57693014
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56606973
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.56006819
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54390853
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53643710
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52457365
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51561440
58* KDM5A_27292631_Chip-Seq_BREAST_Human1.49802501
59LXR_22292898_ChIP-Seq_THP-1_Human1.49014116
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45854838
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.44330259
62GABP_19822575_ChIP-Seq_HepG2_Human1.37925675
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.37789374
64MYC_18940864_ChIP-ChIP_HL60_Human1.37656547
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.37501910
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.36476181
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.36175392
68* P68_20966046_ChIP-Seq_HELA_Human1.35782810
69ZNF263_19887448_ChIP-Seq_K562_Human1.35166683
70MAF_26560356_Chip-Seq_TH2_Human1.33878295
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33117238
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32082956
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31991748
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31174604
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30791347
76MAF_26560356_Chip-Seq_TH1_Human1.28459678
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28300957
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.27273758
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25813335
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25610581
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24406845
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23954172
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23749847
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23112633
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22308157
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20140960
87UTX_26944678_Chip-Seq_JUKART_Human1.19978049
88BCL6_27268052_Chip-Seq_Bcells_Human1.18608147
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18388636
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18144234
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17860774
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17732030
93BCOR_27268052_Chip-Seq_Bcells_Human1.17633113
94RACK7_27058665_Chip-Seq_MCF-7_Human1.17484524
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16443891
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15510136
97* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14960971
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13655009
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13307835
100TFEB_21752829_ChIP-Seq_HELA_Human1.12160230
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.10866311
102SPI1_23547873_ChIP-Seq_NB4_Human1.10551372
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10070555
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09600758
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08761206
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.08705087
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07712521
108CIITA_25753668_ChIP-Seq_RAJI_Human1.07335245
109* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05172432
110TAF15_26573619_Chip-Seq_HEK293_Human1.04323345
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02282337
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02089526
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02036997
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01106561
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00088047
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99336143
117KDM2B_26808549_Chip-Seq_DND41_Human0.99056244
118NCOR1_26117541_ChIP-Seq_K562_Human0.97685066
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97264473
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97199034
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96764513
122* SMC4_20622854_ChIP-Seq_HELA_Human0.96334455
123MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95887241
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89869501
125VDR_22108803_ChIP-Seq_LS180_Human0.88670624
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88509530
127FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83392079
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83213773
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.81789442
130KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80820433
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80614785
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.79196459
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78617838
134STAT1_20625510_ChIP-Seq_HELA_Human0.78129011
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76486115
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73756924
137ER_23166858_ChIP-Seq_MCF-7_Human0.73218906
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.72240901
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.71069666
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71069666
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.71069666
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70327044
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69601943
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68572707
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.68213275
146SOX2_16153702_ChIP-ChIP_HESCs_Human0.68172434
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.67008566
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.65666866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.37902914
2MP0008057_abnormal_DNA_replication3.20156360
3MP0004381_abnormal_hair_follicle3.06011736
4MP0006292_abnormal_olfactory_placode2.84843938
5MP0003136_yellow_coat_color2.72412079
6MP0003693_abnormal_embryo_hatching2.71115844
7MP0003718_maternal_effect2.33289652
8MP0005423_abnormal_somatic_nervous2.31816649
9MP0001188_hyperpigmentation2.28510663
10MP0005409_darkened_coat_color2.25715178
11MP0009278_abnormal_bone_marrow2.20265137
12MP0005671_abnormal_response_to2.18403468
13MP0009840_abnormal_foam_cell2.16779134
14MP0003111_abnormal_nucleus_morphology2.16232690
15MP0005058_abnormal_lysosome_morphology2.14890517
16MP0001529_abnormal_vocalization2.13609191
17MP0003806_abnormal_nucleotide_metabolis2.13440878
18MP0001905_abnormal_dopamine_level2.10597701
19MP0009785_altered_susceptibility_to2.08210062
20MP0002277_abnormal_respiratory_mucosa2.07643046
21MP0001873_stomach_inflammation2.02370411
22MP0003724_increased_susceptibility_to2.01892826
23* MP0003763_abnormal_thymus_physiology1.92831662
24MP0003786_premature_aging1.91543578
25MP0008058_abnormal_DNA_repair1.89410591
26MP0005000_abnormal_immune_tolerance1.88800591
27MP0002148_abnormal_hypersensitivity_rea1.87626909
28MP0001986_abnormal_taste_sensitivity1.82017880
29MP0001835_abnormal_antigen_presentation1.80873948
30MP0003077_abnormal_cell_cycle1.77766123
31MP0003880_abnormal_central_pattern1.77437397
32MP0001730_embryonic_growth_arrest1.76726203
33MP0005451_abnormal_body_composition1.74166885
34MP0009333_abnormal_splenocyte_physiolog1.71546928
35MP0008932_abnormal_embryonic_tissue1.71545628
36MP0010094_abnormal_chromosome_stability1.71394772
37MP0004233_abnormal_muscle_weight1.68512624
38MP0000678_abnormal_parathyroid_gland1.67714515
39MP0001800_abnormal_humoral_immune1.67476208
40MP0005171_absent_coat_pigmentation1.64660662
41MP0004808_abnormal_hematopoietic_stem1.62692246
42MP0000490_abnormal_crypts_of1.61924381
43* MP0002723_abnormal_immune_serum1.61023512
44MP0000566_synostosis1.58601252
45MP0004957_abnormal_blastocyst_morpholog1.57616788
46MP0001853_heart_inflammation1.57090507
47MP0002102_abnormal_ear_morphology1.54961610
48MP0005025_abnormal_response_to1.54119544
49MP0005075_abnormal_melanosome_morpholog1.49257581
50MP0002877_abnormal_melanocyte_morpholog1.48925002
51MP0004142_abnormal_muscle_tone1.48921775
52MP0000350_abnormal_cell_proliferation1.48179308
53MP0005387_immune_system_phenotype1.47863002
54MP0001790_abnormal_immune_system1.47863002
55MP0002138_abnormal_hepatobiliary_system1.47141715
56MP0002452_abnormal_antigen_presenting1.46011050
57* MP0002420_abnormal_adaptive_immunity1.45757720
58MP0002019_abnormal_tumor_incidence1.45126528
59MP0000920_abnormal_myelination1.44146083
60* MP0001819_abnormal_immune_cell1.43974948
61MP0008995_early_reproductive_senescence1.43188524
62MP0008260_abnormal_autophagy1.40208404
63MP0006276_abnormal_autonomic_nervous1.40127327
64MP0002396_abnormal_hematopoietic_system1.35326800
65MP0008007_abnormal_cellular_replicative1.34386486
66MP0010307_abnormal_tumor_latency1.34217086
67MP0002163_abnormal_gland_morphology1.32456876
68MP0005076_abnormal_cell_differentiation1.32219651
69MP0003315_abnormal_perineum_morphology1.31271838
70MP0002419_abnormal_innate_immunity1.26737090
71MP0002254_reproductive_system_inflammat1.26676935
72MP0003453_abnormal_keratinocyte_physiol1.25724217
73MP0000372_irregular_coat_pigmentation1.25523841
74MP0003950_abnormal_plasma_membrane1.25470337
75MP0005379_endocrine/exocrine_gland_phen1.25182732
76MP0001545_abnormal_hematopoietic_system1.19037416
77MP0005397_hematopoietic_system_phenotyp1.19037416
78MP0002160_abnormal_reproductive_system1.17019358
79MP0001348_abnormal_lacrimal_gland1.16048852
80* MP0002398_abnormal_bone_marrow1.15547036
81* MP0000716_abnormal_immune_system1.15384217
82MP0006082_CNS_inflammation1.14958789
83MP0004947_skin_inflammation1.13525314
84MP0001929_abnormal_gametogenesis1.13397072
85MP0005501_abnormal_skin_physiology1.12715906
86MP0004185_abnormal_adipocyte_glucose1.10328136
87MP0000685_abnormal_immune_system1.09762892
88MP0005174_abnormal_tail_pigmentation1.09486156
89* MP0002080_prenatal_lethality1.08691504
90MP0006036_abnormal_mitochondrial_physio1.07223924
91MP0002405_respiratory_system_inflammati1.07219270
92MP0005410_abnormal_fertilization1.04469440
93* MP0000689_abnormal_spleen_morphology1.04431867
94MP0000015_abnormal_ear_pigmentation1.04328558
95MP0004742_abnormal_vestibular_system1.03240249
96MP0001697_abnormal_embryo_size1.01515043
97* MP0000703_abnormal_thymus_morphology1.00537364
98* MP0002722_abnormal_immune_system0.98712488
99MP0002132_abnormal_respiratory_system0.98587648
100MP0001145_abnormal_male_reproductive0.98370316
101MP0008877_abnormal_DNA_methylation0.97731989
102MP0005310_abnormal_salivary_gland0.97346223
103MP0001672_abnormal_embryogenesis/_devel0.97288434
104MP0005380_embryogenesis_phenotype0.97288434
105MP0001243_abnormal_dermal_layer0.97121749
106MP0002751_abnormal_autonomic_nervous0.96934046
107MP0003938_abnormal_ear_development0.95188424
108MP0000383_abnormal_hair_follicle0.95085779
109MP0001727_abnormal_embryo_implantation0.93898479
110MP0005389_reproductive_system_phenotype0.93810042
111* MP0002429_abnormal_blood_cell0.93413958
112MP0001216_abnormal_epidermal_layer0.93330873
113MP0003699_abnormal_female_reproductive0.93121072
114MP0001851_eye_inflammation0.91596592
115MP0000358_abnormal_cell_content/0.91010709
116MP0003172_abnormal_lysosome_physiology0.88401254
117MP0001764_abnormal_homeostasis0.87815319
118MP0001849_ear_inflammation0.86199984
119MP0003186_abnormal_redox_activity0.85384493
120MP0000858_altered_metastatic_potential0.84901179
121MP0003303_peritoneal_inflammation0.83548792
122MP0002796_impaired_skin_barrier0.83272857
123MP0000653_abnormal_sex_gland0.83242982
124MP0003984_embryonic_growth_retardation0.82751316
125MP0010030_abnormal_orbit_morphology0.82348259
126MP0001119_abnormal_female_reproductive0.80619439
127MP0003436_decreased_susceptibility_to0.79683517
128MP0002822_catalepsy0.79570587
129MP0005464_abnormal_platelet_physiology0.79235854
130* MP0005621_abnormal_cell_physiology0.78415504
131MP0002088_abnormal_embryonic_growth/wei0.77714927
132MP0002210_abnormal_sex_determination0.73079330
133MP0002933_joint_inflammation0.71994453
134MP0001661_extended_life_span0.71197681
135MP0002638_abnormal_pupillary_reflex0.70865498
136MP0000613_abnormal_salivary_gland0.68561297
137MP0003941_abnormal_skin_development0.67360068
138MP0000026_abnormal_inner_ear0.67091577
139MP0001346_abnormal_lacrimal_gland0.63495152
140MP0003448_altered_tumor_morphology0.63228293
141MP0005395_other_phenotype0.61847388
142* MP0000313_abnormal_cell_death0.61793239
143MP0001845_abnormal_inflammatory_respons0.61766422
144MP0006035_abnormal_mitochondrial_morpho0.61691528
145MP0005377_hearing/vestibular/ear_phenot0.61669971
146MP0003878_abnormal_ear_physiology0.61669971
147MP0002752_abnormal_somatic_nervous0.60966408
148MP0005408_hypopigmentation0.59922509
149MP0002938_white_spotting0.58887483
150MP0006072_abnormal_retinal_apoptosis0.58689729

Predicted human phenotypes

RankGene SetZ-score
1Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.50904238
2Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.08099602
3Reticulocytopenia (HP:0001896)4.07842088
4Ragged-red muscle fibers (HP:0003200)4.01990880
5Duplicated collecting system (HP:0000081)3.92756553
6Progressive muscle weakness (HP:0003323)3.69334918
7Parakeratosis (HP:0001036)3.63326819
8Acute necrotizing encephalopathy (HP:0006965)3.54673951
9Renal Fanconi syndrome (HP:0001994)3.54525795
10Abnormality of cells of the erythroid lineage (HP:0012130)3.53620213
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.44207670
123-Methylglutaconic aciduria (HP:0003535)3.42513373
13Abnormality of the renal collecting system (HP:0004742)3.38627328
14Increased hepatocellular lipid droplets (HP:0006565)3.37341429
15Abnormal number of erythroid precursors (HP:0012131)3.29592774
16Progressive external ophthalmoplegia (HP:0000590)3.29360501
17Mitochondrial inheritance (HP:0001427)3.27169487
18Cerebral hypomyelination (HP:0006808)3.12262381
19Poikiloderma (HP:0001029)3.09768521
20Macrocytic anemia (HP:0001972)3.08543249
21Hypergonadotropic hypogonadism (HP:0000815)3.07598998
22Breast hypoplasia (HP:0003187)3.04880466
23Abnormal gallbladder physiology (HP:0012438)2.98250168
24Cholecystitis (HP:0001082)2.98250168
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92196744
26Broad distal phalanx of finger (HP:0009836)2.91281418
27Abnormal mitochondria in muscle tissue (HP:0008316)2.85024625
28Exertional dyspnea (HP:0002875)2.83041085
29Progressive macrocephaly (HP:0004481)2.82326054
30Pallor (HP:0000980)2.79950833
31Testicular atrophy (HP:0000029)2.74074570
32Birth length less than 3rd percentile (HP:0003561)2.73631149
33Abnormality of secondary sexual hair (HP:0009888)2.72070739
34Abnormality of the axillary hair (HP:0100134)2.72070739
35Lipid accumulation in hepatocytes (HP:0006561)2.71253649
36Squamous cell carcinoma (HP:0002860)2.70875317
37Granulocytopenia (HP:0001913)2.65929789
38Increased CSF lactate (HP:0002490)2.65800781
39Hepatocellular necrosis (HP:0001404)2.64193567
40Entropion (HP:0000621)2.63712896
41Abnormality of DNA repair (HP:0003254)2.56116771
42Abnormality of pyrimidine metabolism (HP:0004353)2.55673861
43Chromsome breakage (HP:0040012)2.54884959
44Congenital ichthyosiform erythroderma (HP:0007431)2.52545260
45Hypertensive crisis (HP:0100735)2.49429346
46Acute encephalopathy (HP:0006846)2.48375887
47Exercise intolerance (HP:0003546)2.42409598
48Amniotic constriction ring (HP:0009775)2.42275810
49Abnormality of placental membranes (HP:0011409)2.42275810
50Abnormal protein glycosylation (HP:0012346)2.36555337
51Abnormal glycosylation (HP:0012345)2.36555337
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36555337
53Abnormal protein N-linked glycosylation (HP:0012347)2.36555337
54Increased serum lactate (HP:0002151)2.33641784
55Stomach cancer (HP:0012126)2.33186036
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33107462
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33107462
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32193239
59Abnormality of renal resorption (HP:0011038)2.31258669
60Optic disc pallor (HP:0000543)2.30909989
61Type 2 muscle fiber atrophy (HP:0003554)2.25723698
62J-shaped sella turcica (HP:0002680)2.25319829
63Increased IgM level (HP:0003496)2.21912151
64Combined immunodeficiency (HP:0005387)2.18850442
65IgM deficiency (HP:0002850)2.18262445
66IgG deficiency (HP:0004315)2.18044128
67Hepatosplenomegaly (HP:0001433)2.17827010
68Abnormal trabecular bone morphology (HP:0100671)2.16810829
69Hepatic necrosis (HP:0002605)2.15341966
70Upper motor neuron abnormality (HP:0002127)2.12694545
71IgA deficiency (HP:0002720)2.12172970
72Premature ovarian failure (HP:0008209)2.12061720
73Facial hemangioma (HP:0000329)2.11432452
74Stomatitis (HP:0010280)2.10828541
75Respiratory difficulties (HP:0002880)2.10498245
76Abnormality of eosinophils (HP:0001879)2.10247055
77Abnormality of reticulocytes (HP:0004312)2.06536767
78Microretrognathia (HP:0000308)2.05706638
79Gastrointestinal stroma tumor (HP:0100723)2.05532068
80Increased intramyocellular lipid droplets (HP:0012240)2.05475473
81Muscle fiber atrophy (HP:0100295)2.05419506
82Chronic obstructive pulmonary disease (HP:0006510)2.05351130
83Obstructive lung disease (HP:0006536)2.05351130
84Aplasia/hypoplasia of the uterus (HP:0008684)2.03029947
85Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02627186
86Prolonged neonatal jaundice (HP:0006579)2.02296463
87Trismus (HP:0000211)2.01816837
88Microvesicular hepatic steatosis (HP:0001414)2.01674378
89Loss of speech (HP:0002371)2.01500655
90Eosinophilia (HP:0001880)2.00798221
91External ophthalmoplegia (HP:0000544)2.00391860
92Conical tooth (HP:0000698)1.98997367
93Long palpebral fissure (HP:0000637)1.98698367
94Dysphonia (HP:0001618)1.98135419
95Increased serum pyruvate (HP:0003542)1.97604876
96Abnormality of glycolysis (HP:0004366)1.97604876
97Multiple enchondromatosis (HP:0005701)1.96755205
98Abnormality of macrophages (HP:0004311)1.96568116
99Carpal bone hypoplasia (HP:0001498)1.96236723
100Shoulder girdle muscle weakness (HP:0003547)1.96155606
101Elevated erythrocyte sedimentation rate (HP:0003565)1.94657972
102Septo-optic dysplasia (HP:0100842)1.92530350
103Triphalangeal thumb (HP:0001199)1.91673257
104Horseshoe kidney (HP:0000085)1.91369519
105Absent radius (HP:0003974)1.90877171
106Erythroderma (HP:0001019)1.88921839
107Aplasia involving forearm bones (HP:0009822)1.88809210
108Absent forearm bone (HP:0003953)1.88809210
109Rough bone trabeculation (HP:0100670)1.88478914
110Proximal placement of thumb (HP:0009623)1.87778643
111Type I transferrin isoform profile (HP:0003642)1.87312050
112Abnormality of the preputium (HP:0100587)1.87294287
11311 pairs of ribs (HP:0000878)1.86796845
114Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86736779
115Flattened epiphyses (HP:0003071)1.86043851
116Impaired proprioception (HP:0010831)1.85962626
117Recurrent viral infections (HP:0004429)1.85595502
118Hyperacusis (HP:0010780)1.84737951
119Leukodystrophy (HP:0002415)1.84428237
120Absent hand (HP:0004050)1.84383772
121Aplasia/Hypoplasia of the patella (HP:0006498)1.84358823
122Respiratory failure (HP:0002878)1.83953551
123Absent thumb (HP:0009777)1.83429901
124Pancytopenia (HP:0001876)1.83136629
125Asplenia (HP:0001746)1.81702683
126Cleft eyelid (HP:0000625)1.81160730
127Ureteral duplication (HP:0000073)1.80904937
128Severe combined immunodeficiency (HP:0004430)1.80677173
129Myelodysplasia (HP:0002863)1.80646960
130Agammaglobulinemia (HP:0004432)1.80590802
131Abnormality of cochlea (HP:0000375)1.79528329
132Abnormality of the septum pellucidum (HP:0007375)1.78871963
133Mediastinal lymphadenopathy (HP:0100721)1.78861188
134Aplasia/Hypoplasia of the thymus (HP:0010515)1.78826982
135Fibular aplasia (HP:0002990)1.75843993
136Selective tooth agenesis (HP:0001592)1.75725851
137Seborrheic dermatitis (HP:0001051)1.75669572
138Abnormal enzyme/coenzyme activity (HP:0012379)1.75607807
139Secondary amenorrhea (HP:0000869)1.75310349
140Aplasia of the musculature (HP:0100854)1.75131354
141Cholelithiasis (HP:0001081)1.74858595
142Gastrointestinal inflammation (HP:0004386)1.74690331
143T lymphocytopenia (HP:0005403)1.74619768
144Distal upper limb amyotrophy (HP:0007149)1.73947078
145Upper limb amyotrophy (HP:0009129)1.73947078
146Abnormality of alkaline phosphatase activity (HP:0004379)1.73804551
147Pancreatic cysts (HP:0001737)1.73756377
148Lymphoma (HP:0002665)1.73507248
149Short thumb (HP:0009778)1.72491427
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.72184126
151Deviation of the thumb (HP:0009603)1.72074272
152Small intestinal stenosis (HP:0012848)1.71969393
153Duodenal stenosis (HP:0100867)1.71969393
154CNS hypomyelination (HP:0003429)1.71882083
155Leukocytosis (HP:0001974)1.71611129
156Lactic acidosis (HP:0003128)1.71567214
157Hypothermia (HP:0002045)1.71497160
158Abnormality of T cell number (HP:0011839)1.70867741
159Lymphopenia (HP:0001888)1.70364193
160Meckel diverticulum (HP:0002245)1.70307055
161Absent septum pellucidum (HP:0001331)1.69971900
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.69796084
163Reticulocytosis (HP:0001923)1.69710124
164Myopathic facies (HP:0002058)1.68415054
165Elevated alkaline phosphatase (HP:0003155)1.66710658
166Cutaneous melanoma (HP:0012056)1.66306055
167Cellulitis (HP:0100658)1.65485136
168Increased muscle lipid content (HP:0009058)1.65205725
169Short nail (HP:0001799)1.64644730
170Basal cell carcinoma (HP:0002671)1.63834996
171Dicarboxylic aciduria (HP:0003215)1.63791536
172Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63791536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.54336851
2BUB14.09830217
3STK163.72398371
4SMG13.45828468
5IRAK43.45268919
6VRK22.72157748
7ERN12.63040533
8IRAK22.59643509
9PBK2.50217645
10IRAK12.50173299
11PLK42.46778471
12ZAK2.35501337
13TLK12.26841111
14TRIB32.18336173
15MST42.13990992
16PNCK2.08258838
17MST1R2.02506974
18SRPK12.00026520
19WEE11.98826060
20NME21.92789570
21TESK11.92032041
22PRPF4B1.89165897
23TESK21.84644013
24CASK1.78355501
25CDK121.77906004
26MARK11.77513420
27BCKDK1.73229381
28MET1.69672387
29TAOK21.65942738
30BLK1.64600028
31EIF2AK31.64148302
32TXK1.58973750
33BMPR1B1.56592655
34ICK1.55392576
35VRK11.53402664
36KDR1.47631362
37NME11.45254641
38EEF2K1.43580776
39NEK11.39614697
40ARAF1.34805373
41TSSK61.31073901
42EIF2AK11.28260465
43BMX1.25583370
44MAP3K111.24276998
45SCYL21.22899106
46STK391.22143947
47MKNK21.20914212
48MAPK111.19561074
49MAP4K11.18601469
50MKNK11.18215811
51MAP3K101.15606106
52CLK11.14762413
53CDK41.14531765
54EIF2AK21.13504661
55MAP3K81.09563246
56PKN11.09045643
57RPS6KA51.07446532
58EPHA21.06144820
59NEK20.99794359
60CHEK10.98840911
61TNIK0.98268034
62MAP3K140.97952687
63SIK20.94879249
64IKBKB0.94209432
65DYRK30.92973887
66MAP2K20.91295528
67CSF1R0.89602267
68DYRK20.86452353
69MAPKAPK50.86371074
70OXSR10.85359304
71RPS6KB20.84828657
72TAOK10.83077057
73GRK70.80493360
74CDK190.77635564
75TTK0.76831259
76PAK40.76092516
77SIK10.75605558
78CCNB10.75026494
79ADRBK20.74641612
80STK100.73993687
81EPHA30.73502110
82CAMK2B0.72479016
83PLK30.72389481
84PIM20.72131649
85IKBKE0.71500218
86FES0.71343970
87TAF10.71297925
88PIM10.71000568
89GRK10.70595666
90BTK0.70158359
91MARK30.70150120
92DAPK10.68719379
93BRSK10.68635960
94TEC0.67584620
95MUSK0.66560567
96PASK0.66273709
97MATK0.66272846
98PLK10.66214793
99LYN0.65499571
100BMPR20.65125872
101LCK0.64507129
102PDK20.64076481
103NLK0.63926508
104BCR0.60718577
105AURKA0.57809441
106YES10.57612151
107ROCK20.57429541
108MTOR0.56237068
109CDK90.55701166
110TNK20.55655707
111NEK60.55073125
112PRKCI0.54503744
113ATR0.53196068
114RAF10.52815583
115TYK20.52409415
116CSNK2A10.50074865
117CAMK2D0.50046917
118JAK30.49559658
119STK40.48473709
120CDK20.48237420
121CSNK2A20.48095591
122ZAP700.47736961
123SYK0.47439794
124KIT0.47249281
125CAMK1G0.46634760
126RIPK40.46392875
127CAMK1D0.46014935
128ABL20.45644160
129GRK60.45385512
130ITK0.43504632
131FGR0.43404736
132CSNK1G30.43035529
133ACVR1B0.42719988
134AURKB0.42294220
135CDK70.42279996
136CAMK2G0.42120911
137TBK10.41582286
138CDK10.40776410
139CDK60.40748790
140FGFR40.40151230
141PTK60.39927461
142SIK30.39908073
143CDC70.39148379
144CHEK20.37648627
145RPS6KA10.37186472
146RPS6KA40.34907405
147PAK10.33272333
148PIK3CG0.32879065
149BRAF0.32793156
150PRKCE0.32630170
151MAPK40.32199544
152PRKCQ0.31774014
153NUAK10.31503451
154CDK80.30938942

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.59651377
2Proteasome_Homo sapiens_hsa030504.25371580
3RNA polymerase_Homo sapiens_hsa030203.64242366
4Oxidative phosphorylation_Homo sapiens_hsa001903.09310269
5DNA replication_Homo sapiens_hsa030302.97535213
6Mismatch repair_Homo sapiens_hsa034302.68017368
7Parkinsons disease_Homo sapiens_hsa050122.42241616
8Spliceosome_Homo sapiens_hsa030402.33123397
9Pyrimidine metabolism_Homo sapiens_hsa002402.31300236
10Homologous recombination_Homo sapiens_hsa034402.27223971
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24749585
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23034536
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17057781
14Nucleotide excision repair_Homo sapiens_hsa034202.07248480
15Fanconi anemia pathway_Homo sapiens_hsa034601.97283402
16Protein export_Homo sapiens_hsa030601.95920812
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.89613964
18Huntingtons disease_Homo sapiens_hsa050161.88851548
19Biosynthesis of amino acids_Homo sapiens_hsa012301.83289524
20Alzheimers disease_Homo sapiens_hsa050101.77822535
21Primary immunodeficiency_Homo sapiens_hsa053401.73763967
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72416973
23Basal transcription factors_Homo sapiens_hsa030221.71627338
24Graft-versus-host disease_Homo sapiens_hsa053321.51818850
25* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46487091
26Fructose and mannose metabolism_Homo sapiens_hsa000511.41758555
27Base excision repair_Homo sapiens_hsa034101.40062946
28Allograft rejection_Homo sapiens_hsa053301.38938791
29Purine metabolism_Homo sapiens_hsa002301.32775222
30Autoimmune thyroid disease_Homo sapiens_hsa053201.31495208
31RNA transport_Homo sapiens_hsa030131.29629423
32Non-homologous end-joining_Homo sapiens_hsa034501.27718888
33RNA degradation_Homo sapiens_hsa030181.22761876
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.20637279
35Arachidonic acid metabolism_Homo sapiens_hsa005901.19983324
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19527571
37Ether lipid metabolism_Homo sapiens_hsa005651.16809250
38Linoleic acid metabolism_Homo sapiens_hsa005911.15906795
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13252209
40Fatty acid elongation_Homo sapiens_hsa000621.13002495
41* NF-kappa B signaling pathway_Homo sapiens_hsa040641.12256501
42N-Glycan biosynthesis_Homo sapiens_hsa005101.10831428
43Carbon metabolism_Homo sapiens_hsa012001.08366568
44* Epstein-Barr virus infection_Homo sapiens_hsa051691.08287681
45Galactose metabolism_Homo sapiens_hsa000521.06420651
46Acute myeloid leukemia_Homo sapiens_hsa052211.04889419
47Sphingolipid metabolism_Homo sapiens_hsa006001.03160686
48Steroid biosynthesis_Homo sapiens_hsa001001.01487809
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.00320823
50Hematopoietic cell lineage_Homo sapiens_hsa046400.97310276
51Cell cycle_Homo sapiens_hsa041100.96883528
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96869869
53Bladder cancer_Homo sapiens_hsa052190.96797159
54Asthma_Homo sapiens_hsa053100.96242206
55Rheumatoid arthritis_Homo sapiens_hsa053230.95827783
56Phototransduction_Homo sapiens_hsa047440.94537129
57One carbon pool by folate_Homo sapiens_hsa006700.90742758
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89634994
59p53 signaling pathway_Homo sapiens_hsa041150.88455617
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87723191
61* Apoptosis_Homo sapiens_hsa042100.87705555
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86124330
63Measles_Homo sapiens_hsa051620.81865118
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.80119525
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79093907
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78511154
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77479344
68Chronic myeloid leukemia_Homo sapiens_hsa052200.76396130
69Glutathione metabolism_Homo sapiens_hsa004800.74799399
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74159133
71Hepatitis B_Homo sapiens_hsa051610.73229222
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.72753595
73* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72470790
74Influenza A_Homo sapiens_hsa051640.71944315
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71281565
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70516306
77Collecting duct acid secretion_Homo sapiens_hsa049660.65869542
78Folate biosynthesis_Homo sapiens_hsa007900.65629675
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63864081
80Legionellosis_Homo sapiens_hsa051340.62179411
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62155543
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.61546939
83Antigen processing and presentation_Homo sapiens_hsa046120.60507536
84Oocyte meiosis_Homo sapiens_hsa041140.58775041
85Cardiac muscle contraction_Homo sapiens_hsa042600.58595249
86Systemic lupus erythematosus_Homo sapiens_hsa053220.56563442
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56548667
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54639489
89Sulfur metabolism_Homo sapiens_hsa009200.54051913
90* TNF signaling pathway_Homo sapiens_hsa046680.53325423
91Viral myocarditis_Homo sapiens_hsa054160.52583023
92Malaria_Homo sapiens_hsa051440.52546954
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52412988
94Metabolic pathways_Homo sapiens_hsa011000.51542085
95T cell receptor signaling pathway_Homo sapiens_hsa046600.51200001
96Salmonella infection_Homo sapiens_hsa051320.51123415
97Arginine and proline metabolism_Homo sapiens_hsa003300.50864469
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50257653
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50188296
100Type I diabetes mellitus_Homo sapiens_hsa049400.49761612
101* Herpes simplex infection_Homo sapiens_hsa051680.49691802
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48923072
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48207913
104Histidine metabolism_Homo sapiens_hsa003400.48050948
105Selenocompound metabolism_Homo sapiens_hsa004500.47940227
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47176773
107Thyroid cancer_Homo sapiens_hsa052160.47016954
108Lysosome_Homo sapiens_hsa041420.45977441
109Non-small cell lung cancer_Homo sapiens_hsa052230.45584779
110Lysine degradation_Homo sapiens_hsa003100.44187919
111Pyruvate metabolism_Homo sapiens_hsa006200.43620870
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43090643
113Leishmaniasis_Homo sapiens_hsa051400.42661073
114* Small cell lung cancer_Homo sapiens_hsa052220.41105369
115* Hepatitis C_Homo sapiens_hsa051600.41073490
116Vitamin B6 metabolism_Homo sapiens_hsa007500.40144240
117Other glycan degradation_Homo sapiens_hsa005110.39563532
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39073250
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38567187
120Notch signaling pathway_Homo sapiens_hsa043300.38342509
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37754287
122* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37490586
123African trypanosomiasis_Homo sapiens_hsa051430.37104972
124Pancreatic cancer_Homo sapiens_hsa052120.36819136
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36409035
126Vitamin digestion and absorption_Homo sapiens_hsa049770.36213495
127Serotonergic synapse_Homo sapiens_hsa047260.35304692
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34660057
129Pertussis_Homo sapiens_hsa051330.32999676
130mRNA surveillance pathway_Homo sapiens_hsa030150.30370928
131Shigellosis_Homo sapiens_hsa051310.28729925
132Phagosome_Homo sapiens_hsa041450.27948089
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26454880
134Regulation of autophagy_Homo sapiens_hsa041400.24692014
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24130855
136Vibrio cholerae infection_Homo sapiens_hsa051100.23512576
137Tyrosine metabolism_Homo sapiens_hsa003500.22174680
138* Viral carcinogenesis_Homo sapiens_hsa052030.21013565
139Sulfur relay system_Homo sapiens_hsa041220.19568436
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16796718
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.16729743
142B cell receptor signaling pathway_Homo sapiens_hsa046620.16599312
143HTLV-I infection_Homo sapiens_hsa051660.15249052
144Pentose phosphate pathway_Homo sapiens_hsa000300.14458592
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12791131

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