TRAF3IP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.89098088
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.44102871
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.44102871
4antigen processing and presentation of endogenous antigen (GO:0019883)6.00075449
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.53988584
6negative T cell selection (GO:0043383)5.36169156
7regulation of gamma-delta T cell differentiation (GO:0045586)5.34397340
8negative thymic T cell selection (GO:0045060)5.18925599
9positive thymic T cell selection (GO:0045059)5.15120888
10regulation of gamma-delta T cell activation (GO:0046643)4.97752354
11negative regulation of cell killing (GO:0031342)4.85952939
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85952939
13regulation of B cell receptor signaling pathway (GO:0050855)4.85083673
14positive T cell selection (GO:0043368)4.69926968
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64091162
16response to interleukin-15 (GO:0070672)4.56988252
17B cell receptor signaling pathway (GO:0050853)4.54377247
18T cell selection (GO:0045058)4.40435914
19cellular response to interleukin-15 (GO:0071350)4.38485404
20leukocyte aggregation (GO:0070486)4.37863117
21thymic T cell selection (GO:0045061)4.36001883
22regulation of B cell differentiation (GO:0045577)4.28156252
23interferon-gamma production (GO:0032609)4.26597018
24T cell migration (GO:0072678)4.26572567
25positive regulation of B cell differentiation (GO:0045579)4.15369782
26ribosomal small subunit assembly (GO:0000028)4.03748699
27antigen receptor-mediated signaling pathway (GO:0050851)4.00858915
28mast cell activation (GO:0045576)3.98519070
29regulation of isotype switching to IgG isotypes (GO:0048302)3.94057754
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.93174617
31T cell receptor signaling pathway (GO:0050852)3.89912357
32detection of bacterium (GO:0016045)3.86643615
33detection of other organism (GO:0098543)3.86203311
34positive regulation by symbiont of host defense response (GO:0052509)3.84983190
35modulation by symbiont of host defense response (GO:0052031)3.84983190
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84983190
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84983190
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.84983190
39modulation by symbiont of host immune response (GO:0052553)3.84983190
40T cell homeostasis (GO:0043029)3.82705814
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.82283145
42regulation of T cell mediated cytotoxicity (GO:0001914)3.78975297
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.76634109
44regulation of natural killer cell mediated immunity (GO:0002715)3.76634109
45regulation of T cell tolerance induction (GO:0002664)3.73740691
46negative regulation of leukocyte mediated immunity (GO:0002704)3.73256751
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.72083352
48regulation of regulatory T cell differentiation (GO:0045589)3.63825399
49regulation of alpha-beta T cell proliferation (GO:0046640)3.62744984
50tolerance induction (GO:0002507)3.59345110
51regulation of T cell receptor signaling pathway (GO:0050856)3.59334086
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.59176604
53T cell costimulation (GO:0031295)3.55746067
54neutrophil activation involved in immune response (GO:0002283)3.55115867
55antigen processing and presentation via MHC class Ib (GO:0002475)3.52590209
56lymphocyte costimulation (GO:0031294)3.51155228
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.42716978
58lymphocyte homeostasis (GO:0002260)3.42559504
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42053101
60negative regulation of phagocytosis (GO:0050765)3.39308698
61negative regulation of interleukin-12 production (GO:0032695)3.38459338
62mast cell degranulation (GO:0043303)3.38366954
63mast cell activation involved in immune response (GO:0002279)3.38366954
64cellular extravasation (GO:0045123)3.33626027
65positive regulation of interleukin-2 production (GO:0032743)3.32018422
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.29054123
67neutrophil activation (GO:0042119)3.28155873
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27483112
69respiratory burst (GO:0045730)3.24931814
70NIK/NF-kappaB signaling (GO:0038061)3.22618481
71positive regulation of tolerance induction (GO:0002645)3.21630137
72positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19102602
73regulation of cell killing (GO:0031341)3.18171032
74positive regulation of granulocyte differentiation (GO:0030854)3.17972790
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16414039
76macrophage activation involved in immune response (GO:0002281)3.16270852
77lymph node development (GO:0048535)3.16018091
78mature B cell differentiation (GO:0002335)3.11253123
79regulation of interleukin-2 biosynthetic process (GO:0045076)3.10644637
80positive regulation of natural killer cell mediated immunity (GO:0002717)3.10411624
81leukocyte homeostasis (GO:0001776)3.10079444
82B cell mediated immunity (GO:0019724)3.09947090
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09749464
84myeloid cell activation involved in immune response (GO:0002275)3.08714955
85viral transcription (GO:0019083)3.08327705
86positive regulation of cell killing (GO:0031343)3.06345437
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04976904
88cytidine deamination (GO:0009972)3.03918407
89cytidine metabolic process (GO:0046087)3.03918407
90cytidine catabolic process (GO:0006216)3.03918407
91regulation of alpha-beta T cell activation (GO:0046634)3.02801300
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02033314
93positive regulation of isotype switching (GO:0045830)3.01054927
94regulation of interferon-beta biosynthetic process (GO:0045357)3.01007081
95detection of external biotic stimulus (GO:0098581)3.00574255
96response to type I interferon (GO:0034340)3.00424324
97defense response to protozoan (GO:0042832)2.99839392
98dendritic cell chemotaxis (GO:0002407)2.99796796
99cellular response to zinc ion (GO:0071294)2.99297192
100regulation of tolerance induction (GO:0002643)2.97877131
101immune response-activating cell surface receptor signaling pathway (GO:0002429)2.97857977
102granulocyte activation (GO:0036230)2.97307149
103leukocyte degranulation (GO:0043299)2.97245420
104response to protozoan (GO:0001562)2.96829337
105negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.96719504
106pyrimidine ribonucleoside catabolic process (GO:0046133)2.95530021
107B cell homeostasis (GO:0001782)2.93884364
108cellular response to type I interferon (GO:0071357)2.93337921
109type I interferon signaling pathway (GO:0060337)2.93337921
110negative regulation of T cell mediated immunity (GO:0002710)2.93090665
111cellular response to interferon-beta (GO:0035458)2.92386416
112dendritic cell migration (GO:0036336)2.91912823
113regulation of antigen processing and presentation (GO:0002577)2.91792125
114translational termination (GO:0006415)2.91789350
115regulation of granulocyte differentiation (GO:0030852)2.91622975
116negative regulation of erythrocyte differentiation (GO:0045647)2.91080325
117negative regulation of innate immune response (GO:0045824)2.90192897
118regulation of isotype switching (GO:0045191)2.89773655
119regulation of T cell mediated immunity (GO:0002709)2.89570120
120B cell proliferation (GO:0042100)2.87123033
121T cell differentiation (GO:0030217)2.86345398
122regulation of response to interferon-gamma (GO:0060330)2.84578710
123V(D)J recombination (GO:0033151)2.83144287
124myeloid dendritic cell activation (GO:0001773)2.82632912
125interferon-gamma-mediated signaling pathway (GO:0060333)2.81793603
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80528743
127natural killer cell activation (GO:0030101)2.80220087
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78287126
129megakaryocyte development (GO:0035855)2.77560282
130immunoglobulin mediated immune response (GO:0016064)2.77499736
131leukocyte cell-cell adhesion (GO:0007159)2.77211285
132mature B cell differentiation involved in immune response (GO:0002313)2.75646659
133negative regulation of lymphocyte mediated immunity (GO:0002707)2.73778650
134regulation of B cell mediated immunity (GO:0002712)2.70768560
135alpha-beta T cell activation (GO:0046631)2.69613476
136positive regulation of DNA recombination (GO:0045911)2.69152633
137T cell proliferation (GO:0042098)2.69029951
138positive regulation of immunoglobulin production (GO:0002639)2.67811162
139activated T cell proliferation (GO:0050798)2.66298193
140natural killer cell differentiation (GO:0001779)2.66072063
141regulation of interleukin-2 production (GO:0032663)2.65442019
142negative regulation of T cell receptor signaling pathway (GO:0050860)2.64611748
143T cell activation (GO:0042110)2.64032921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.20881402
2E2F7_22180533_ChIP-Seq_HELA_Human4.86333451
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.68394230
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26140644
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.02252178
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44150734
7MYC_22102868_ChIP-Seq_BL_Human3.42869017
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.22244984
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.94212602
10SCL_19346495_ChIP-Seq_HPC-7_Human2.91808590
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.79158402
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.77247697
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76150887
14* MYB_26560356_Chip-Seq_TH2_Human2.74383045
15VDR_21846776_ChIP-Seq_THP-1_Human2.73555542
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.72974222
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68229174
18* RUNX_20019798_ChIP-Seq_JUKART_Human2.67838177
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63712279
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.63138644
21MAF_26560356_Chip-Seq_TH1_Human2.47072144
22MYB_26560356_Chip-Seq_TH1_Human2.43904477
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33434607
24* SPI1_23547873_ChIP-Seq_NB4_Human2.30414188
25* UTX_26944678_Chip-Seq_JUKART_Human2.28197943
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.23458938
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17660912
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.15035946
29* IRF8_27001747_Chip-Seq_BMDM_Mouse2.14817098
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14385297
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11103859
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09320831
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01463847
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.01428442
35VDR_24763502_ChIP-Seq_THP-1_Human1.96392469
36CIITA_25753668_ChIP-Seq_RAJI_Human1.91903103
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89248014
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89016632
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.88833329
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86592621
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80421434
42TCF7_22412390_ChIP-Seq_EML_Mouse1.73688373
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71227317
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70204210
45* MAF_26560356_Chip-Seq_TH2_Human1.67978323
46GATA3_27048872_Chip-Seq_THYMUS_Human1.65631407
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.65323233
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64639806
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60056521
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.59368883
51VDR_23849224_ChIP-Seq_CD4+_Human1.56631479
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.53935793
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53045557
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.51089104
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51006612
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50646854
57SPI1_23127762_ChIP-Seq_K562_Human1.48906980
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44817716
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44693244
60VDR_24787735_ChIP-Seq_THP-1_Human1.40000763
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34978428
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34410057
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25838517
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25837642
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25364269
66* PU_27001747_Chip-Seq_BMDM_Mouse1.21429768
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20954788
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.18194387
69GATA1_22025678_ChIP-Seq_K562_Human1.18157712
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17176281
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.16703410
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.16286432
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15100015
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13705070
75* GATA3_26560356_Chip-Seq_TH2_Human1.13176806
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12157466
77BCL6_27268052_Chip-Seq_Bcells_Human1.11052382
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10585989
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09994736
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09571839
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08936569
82* KDM2B_26808549_Chip-Seq_DND41_Human1.08407494
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06533041
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04626456
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04143182
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04112607
87ELK1_19687146_ChIP-ChIP_HELA_Human0.98539407
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97252174
89GATA1_19941826_ChIP-Seq_K562_Human0.97198239
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95715188
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.94819273
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.94708296
93* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94022119
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93409642
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93211329
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92922722
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91802494
98BCOR_27268052_Chip-Seq_Bcells_Human0.91431757
99* XRN2_22483619_ChIP-Seq_HELA_Human0.90523449
100* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90177406
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90169003
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89792309
103MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89069705
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88684586
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.87160234
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87126249
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.87054283
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.86755089
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86520588
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86379652
111P300_27268052_Chip-Seq_Bcells_Human0.86280771
112MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84616747
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84074893
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83752598
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83640104
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83421120
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82183403
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81850435
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81728236
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80648813
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80351196
122SPI1_20517297_ChIP-Seq_HL60_Human0.79677966
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79504590
124* GATA3_26560356_Chip-Seq_TH1_Human0.77925187
125* SMRT_27268052_Chip-Seq_Bcells_Human0.77289408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.28924557
2MP0001835_abnormal_antigen_presentation4.28623513
3MP0005671_abnormal_response_to3.92135356
4MP0000685_abnormal_immune_system3.63980637
5MP0001800_abnormal_humoral_immune3.50327443
6MP0002396_abnormal_hematopoietic_system3.42029801
7MP0005387_immune_system_phenotype3.17318913
8MP0001790_abnormal_immune_system3.17318913
9MP0002420_abnormal_adaptive_immunity2.92277450
10MP0002398_abnormal_bone_marrow2.92079371
11MP0002452_abnormal_antigen_presenting2.91148140
12MP0001819_abnormal_immune_cell2.87734778
13MP0002723_abnormal_immune_serum2.86656019
14MP0005000_abnormal_immune_tolerance2.85318992
15MP0009785_altered_susceptibility_to2.75999921
16MP0002166_altered_tumor_susceptibility2.74733579
17MP0000716_abnormal_immune_system2.56843579
18MP0005025_abnormal_response_to2.55866962
19MP0000689_abnormal_spleen_morphology2.43071875
20MP0002722_abnormal_immune_system2.36632480
21MP0003436_decreased_susceptibility_to2.33456689
22MP0000703_abnormal_thymus_morphology2.33433165
23MP0009333_abnormal_splenocyte_physiolog2.30674093
24MP0001873_stomach_inflammation2.28694201
25MP0002148_abnormal_hypersensitivity_rea2.21014507
26MP0002419_abnormal_innate_immunity2.19547515
27MP0004808_abnormal_hematopoietic_stem2.19536915
28MP0002006_tumorigenesis2.19289661
29MP0002405_respiratory_system_inflammati2.17021026
30MP0002429_abnormal_blood_cell2.16061644
31MP0005464_abnormal_platelet_physiology2.12048108
32MP0010155_abnormal_intestine_physiology2.07329693
33MP0003866_abnormal_defecation1.89849717
34MP0003303_peritoneal_inflammation1.81840345
35MP0001853_heart_inflammation1.71227255
36MP0005397_hematopoietic_system_phenotyp1.70925832
37MP0001545_abnormal_hematopoietic_system1.70925832
38MP0001845_abnormal_inflammatory_respons1.70367478
39MP0003724_increased_susceptibility_to1.68213060
40MP0000465_gastrointestinal_hemorrhage1.64876888
41MP0005174_abnormal_tail_pigmentation1.62562451
42MP0004947_skin_inflammation1.62143959
43MP0005075_abnormal_melanosome_morpholog1.60139606
44MP0006082_CNS_inflammation1.57852651
45MP0000490_abnormal_crypts_of1.56175535
46MP0008057_abnormal_DNA_replication1.55686660
47MP0003300_gastrointestinal_ulcer1.53722364
48MP0002933_joint_inflammation1.52763207
49MP0009278_abnormal_bone_marrow1.38678067
50MP0010094_abnormal_chromosome_stability1.37827166
51MP0003693_abnormal_embryo_hatching1.35600151
52MP0008058_abnormal_DNA_repair1.29653303
53MP0003077_abnormal_cell_cycle1.22230968
54MP0002019_abnormal_tumor_incidence1.21345219
55MP0008260_abnormal_autophagy1.17828059
56MP0004510_myositis1.16813205
57MP0008469_abnormal_protein_level1.13029210
58MP0000858_altered_metastatic_potential1.11974983
59MP0005310_abnormal_salivary_gland1.11023988
60MP0002095_abnormal_skin_pigmentation1.10629611
61MP0000015_abnormal_ear_pigmentation1.05097355
62MP0008007_abnormal_cellular_replicative1.01705464
63MP0004883_abnormal_blood_vessel1.00272908
64MP0003183_abnormal_peptide_metabolism0.99297070
65MP0003045_fibrosis0.98081110
66MP0002138_abnormal_hepatobiliary_system0.97504354
67MP0005451_abnormal_body_composition0.94139012
68MP0002132_abnormal_respiratory_system0.92017631
69MP0001533_abnormal_skeleton_physiology0.90914034
70MP0004381_abnormal_hair_follicle0.90813006
71MP0001986_abnormal_taste_sensitivity0.90121618
72MP0003111_abnormal_nucleus_morphology0.86502339
73MP0005166_decreased_susceptibility_to0.81020995
74MP0003448_altered_tumor_morphology0.80997610
75MP0003172_abnormal_lysosome_physiology0.79930633
76MP0004957_abnormal_blastocyst_morpholog0.78459049
77MP0003690_abnormal_glial_cell0.73896593
78MP0000313_abnormal_cell_death0.73136460
79MP0001851_eye_inflammation0.69826388
80MP0009764_decreased_sensitivity_to0.69785795
81MP0010352_gastrointestinal_tract_polyps0.64632919
82MP0003075_altered_response_to0.64443852
83MP0001663_abnormal_digestive_system0.63921822
84MP0005164_abnormal_response_to0.63671166
85MP0002009_preneoplasia0.63544463
86MP0005390_skeleton_phenotype0.63525330
87MP0004130_abnormal_muscle_cell0.63258357
88MP0009763_increased_sensitivity_to0.62693044
89MP0002693_abnormal_pancreas_physiology0.61607070
90MP0009765_abnormal_xenobiotic_induced0.60074224
91MP0000249_abnormal_blood_vessel0.59897506
92MP0000569_abnormal_digit_pigmentation0.59689253
93MP0006054_spinal_hemorrhage0.58163493
94MP0000477_abnormal_intestine_morphology0.57098417
95MP0010307_abnormal_tumor_latency0.55877116
96MP0000604_amyloidosis0.55732529
97MP0002998_abnormal_bone_remodeling0.55428249
98MP0005058_abnormal_lysosome_morphology0.52312287
99MP0003252_abnormal_bile_duct0.51526261
100MP0008874_decreased_physiological_sensi0.50938085
101MP0001348_abnormal_lacrimal_gland0.50575324
102MP0002928_abnormal_bile_duct0.50485838
103MP0002277_abnormal_respiratory_mucosa0.50019423
104MP0003786_premature_aging0.49710847
105MP0000350_abnormal_cell_proliferation0.49381949
106MP0003191_abnormal_cellular_cholesterol0.49048632
107MP0003943_abnormal_hepatobiliary_system0.48840532
108MP0002136_abnormal_kidney_physiology0.48278557
109MP0003656_abnormal_erythrocyte_physiolo0.48222674
110MP0001765_abnormal_ion_homeostasis0.46370500
111MP0003795_abnormal_bone_structure0.46118218
112MP0005023_abnormal_wound_healing0.46108414
113MP0000371_diluted_coat_color0.45600168
114MP0008961_abnormal_basal_metabolism0.44216073
115MP0003787_abnormal_imprinting0.43842304
116MP0008004_abnormal_stomach_pH0.42619907
117MP0003828_pulmonary_edema0.42230929
118MP0001191_abnormal_skin_condition0.41984074
119MP0008873_increased_physiological_sensi0.41770450
120MP0002083_premature_death0.40044210
121MP0000609_abnormal_liver_physiology0.39148409
122MP0002075_abnormal_coat/hair_pigmentati0.39142120
123MP0005381_digestive/alimentary_phenotyp0.38795813
124MP0005621_abnormal_cell_physiology0.38362778

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.29653335
2Recurrent bronchitis (HP:0002837)5.13411717
3IgM deficiency (HP:0002850)5.08307109
4Abnormality of T cell number (HP:0011839)5.06221855
5Panhypogammaglobulinemia (HP:0003139)4.98044760
6Agammaglobulinemia (HP:0004432)4.83495370
7Recurrent viral infections (HP:0004429)4.79146023
8Chronic otitis media (HP:0000389)4.65606944
9Elevated erythrocyte sedimentation rate (HP:0003565)4.56168920
10B lymphocytopenia (HP:0010976)4.43465538
11Abnormality of B cell number (HP:0010975)4.43465538
12Recurrent fungal infections (HP:0002841)4.42353550
13Abnormality of T cells (HP:0002843)4.40920149
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.23967027
15Severe combined immunodeficiency (HP:0004430)4.13345102
16Thyroiditis (HP:0100646)4.01639971
17Gastrointestinal infarctions (HP:0005244)3.98969822
18IgG deficiency (HP:0004315)3.92526177
19Chronic mucocutaneous candidiasis (HP:0002728)3.90775066
20Recurrent cutaneous fungal infections (HP:0011370)3.90775066
21Recurrent abscess formation (HP:0002722)3.86000952
22Lymphopenia (HP:0001888)3.84906489
23Meningitis (HP:0001287)3.83945731
24Combined immunodeficiency (HP:0005387)3.80785781
25Thrombocytosis (HP:0001894)3.76397452
26Abnormality of cells of the lymphoid lineage (HP:0012140)3.68817855
27Myositis (HP:0100614)3.67671149
28Abnormality of the fingertips (HP:0001211)3.67423253
29Eczematoid dermatitis (HP:0000976)3.61697026
30Abnormality of T cell physiology (HP:0011840)3.52631537
31Recurrent sinusitis (HP:0011108)3.46964001
32Recurrent gram-negative bacterial infections (HP:0005420)3.45659742
33Gastrointestinal stroma tumor (HP:0100723)3.40892676
34Inflammation of the large intestine (HP:0002037)3.39831471
35Nasal polyposis (HP:0100582)3.38439916
36Cellulitis (HP:0100658)3.37427397
37Gastrointestinal inflammation (HP:0004386)3.36914591
38Hypoplasia of the thymus (HP:0000778)3.34183495
39Recurrent bacterial skin infections (HP:0005406)3.29251117
40Keratoconjunctivitis sicca (HP:0001097)3.24785596
41Eosinophilia (HP:0001880)3.24096307
42Chronic diarrhea (HP:0002028)3.21237294
43Abnormality of eosinophils (HP:0001879)3.17429853
44Vasculitis (HP:0002633)3.16248948
45Keratoconjunctivitis (HP:0001096)3.12868424
46Chronic sinusitis (HP:0011109)3.10252630
47Granulocytopenia (HP:0001913)3.06369408
48Pustule (HP:0200039)3.03756390
49Colitis (HP:0002583)3.02688289
50Recurrent skin infections (HP:0001581)3.01391516
51Lymphoma (HP:0002665)2.98409686
52Stomatitis (HP:0010280)2.97832838
53Abnormality of the nasal mucosa (HP:0000433)2.95561396
54Papilloma (HP:0012740)2.94406405
55Verrucae (HP:0200043)2.94406405
56Mediastinal lymphadenopathy (HP:0100721)2.89509904
57Bronchitis (HP:0012387)2.89064682
58IgA deficiency (HP:0002720)2.85430277
59Spontaneous hematomas (HP:0007420)2.84625180
60Prolonged bleeding time (HP:0003010)2.84288245
61Autoimmune thrombocytopenia (HP:0001973)2.78310011
62Leukocytosis (HP:0001974)2.77895287
63Urticaria (HP:0001025)2.77364373
64Autoimmune hemolytic anemia (HP:0001890)2.72958193
65Obstructive lung disease (HP:0006536)2.70700162
66Chronic obstructive pulmonary disease (HP:0006510)2.70700162
67Gingivitis (HP:0000230)2.64986098
68Encephalitis (HP:0002383)2.64979038
69Arterial thrombosis (HP:0004420)2.61064089
70Hypochromic anemia (HP:0001931)2.59102946
71Pulmonary embolism (HP:0002204)2.58859009
72Petechiae (HP:0000967)2.57673949
73Increased IgE level (HP:0003212)2.46719258
74Anorexia (HP:0002039)2.45046326
75Emphysema (HP:0002097)2.44412740
76Gangrene (HP:0100758)2.39960122
77Epistaxis (HP:0000421)2.38399013
78Poikiloderma (HP:0001029)2.36210148
79Abnormality of the pleura (HP:0002103)2.35933443
80Hypochromic microcytic anemia (HP:0004840)2.34951499
81Papilledema (HP:0001085)2.31981728
82Recurrent otitis media (HP:0000403)2.26495531
83Osteomyelitis (HP:0002754)2.25523443
84Basal cell carcinoma (HP:0002671)2.25419796
85Hypergammaglobulinemia (HP:0010702)2.23219724
86Sepsis (HP:0100806)2.22644649
87Recurrent pneumonia (HP:0006532)2.20922708
88Hemoptysis (HP:0002105)2.18449888
89Acute hepatic failure (HP:0006554)2.18040816
90Recurrent lower respiratory tract infections (HP:0002783)2.14679414
91Retrobulbar optic neuritis (HP:0100654)2.14409608
92Optic neuritis (HP:0100653)2.14409608
93Reticulocytopenia (HP:0001896)2.14224247
94Abnormality of cells of the erythroid lineage (HP:0012130)2.12910179
95Leukopenia (HP:0001882)2.12602670
96Hypoproteinemia (HP:0003075)2.09567572
97Periodontitis (HP:0000704)2.09034174
98Pulmonary infiltrates (HP:0002113)2.09005635
99Aplastic anemia (HP:0001915)2.08981175
100Abnormal number of erythroid precursors (HP:0012131)2.08348996
101Glomerulopathy (HP:0100820)2.08156348
102Chest pain (HP:0100749)2.07975695
103Episodic fever (HP:0001954)2.06903980
104Cheilitis (HP:0100825)2.05429511
105Skin ulcer (HP:0200042)2.04844737
106Abnormality of the prostate (HP:0008775)2.04568321
107Microcytic anemia (HP:0001935)2.02280316
108Restrictive lung disease (HP:0002091)2.01816318
109Stomach cancer (HP:0012126)2.01494815
110Neutropenia (HP:0001875)1.99446768
111Aplasia/Hypoplasia of the thymus (HP:0010515)1.98186796
112Orchitis (HP:0100796)1.97672705
113Increased IgM level (HP:0003496)1.96524829
114Gingival bleeding (HP:0000225)1.96449075
115Entropion (HP:0000621)1.94862424
116Keratitis (HP:0000491)1.94553031
117Abnormality of macrophages (HP:0004311)1.94054606
118Skin rash (HP:0000988)1.92414514
119Viral hepatitis (HP:0006562)1.92243819
120Joint swelling (HP:0001386)1.92224610
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91653632
122Interstitial pulmonary disease (HP:0006530)1.91290610
123Polyneuropathy (HP:0001271)1.89064510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.81428741
2TXK3.97797601
3ZAP702.68468375
4JAK32.63647654
5BLK2.42138432
6TYK22.38876151
7BTK2.36206775
8KIT2.28148429
9TEC2.26635453
10GRK62.26083634
11ITK2.24730310
12STK102.14070592
13IKBKE2.11620791
14PRPF4B2.08608586
15SYK2.07462713
16MAP3K101.94872024
17EEF2K1.94005847
18MAP3K131.92814694
19IRAK41.90650136
20CSF1R1.87650683
21MAP3K141.85470154
22SIK21.75518607
23FGFR41.72104920
24LCK1.70587361
25NLK1.62322452
26JAK11.59751985
27TBK11.55004497
28SIK31.44076233
29HCK1.40711009
30FGFR31.35067365
31FES1.30155046
32CLK11.28675404
33RIPK41.28572863
34NME21.26992424
35LYN1.25980131
36LRRK21.24377381
37IKBKB1.23609202
38TGFBR21.22833031
39FGR1.22469723
40FLT31.20680729
41CSK1.20344325
42PIM11.18678708
43BMPR21.13948095
44MAP3K111.09544950
45CAMKK21.04031886
46KDR1.04012497
47MARK31.03977615
48TNK21.02114209
49EPHB11.02073235
50MAP2K30.99885216
51NEK20.94506488
52PRKCQ0.89679969
53STK160.88445297
54CAMKK10.88442308
55TGFBR10.77050330
56CDK40.76819445
57MAP3K30.76583762
58ERN10.74862322
59STK40.74213367
60TAOK30.74087989
61IRAK30.73017221
62RPS6KA40.72362347
63PKN20.70502450
64MAP3K120.67834480
65MST40.67143548
66BRD40.66604407
67MAP3K10.66191759
68PIK3CG0.66171992
69ATR0.65217597
70PRKCH0.64876780
71TLK10.64712942
72MAP3K70.64620558
73RPS6KB20.64441881
74JAK20.63761285
75ACVR1B0.62946537
76CHUK0.61640364
77TAOK10.60325762
78CDK120.59980657
79ADRBK20.59883515
80IRAK10.58796416
81MAP2K20.57050089
82TESK20.56615045
83HIPK20.54955454
84EIF2AK30.54781546
85GRK70.54407542
86PASK0.53650442
87MAPK110.53043881
88CDC42BPA0.49240292
89TNIK0.48471025
90YES10.47283865
91MAPK40.46878752
92PIM20.45038887
93MAPK70.43598462
94MAPK120.43596946
95PDK10.43056948
96MARK20.40401761
97SRPK10.38223004
98CDC70.37196504
99PDPK10.34578810
100DYRK1B0.34524925
101SCYL20.34329758
102PTK60.33982045
103RPS6KA60.33795472
104PTK2B0.32498708
105STK110.31885456
106SIK10.31561709
107TRPM70.30556808
108RPS6KL10.29958582
109RPS6KC10.29958582
110MAPKAPK20.29856416
111TAOK20.29840200
112EPHA30.29393760
113WEE10.28434963
114MAPK30.28312026
115MELK0.28100562
116ABL10.26896151
117CDK190.26794969
118MAP3K50.26212313
119MATK0.26106508
120VRK10.25307316
121EGFR0.24568280
122CDK60.24426205
123FYN0.24224911
124PRKD20.24111924
125RPS6KA50.23702899
126STK380.23271674
127MAP2K60.22986045
128INSR0.22822738
129PRKCD0.22299946
130IGF1R0.20718889

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.55659943
2B cell receptor signaling pathway_Homo sapiens_hsa046622.74127705
3T cell receptor signaling pathway_Homo sapiens_hsa046602.60751935
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.56447148
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.50470307
6Measles_Homo sapiens_hsa051622.38341689
7Hematopoietic cell lineage_Homo sapiens_hsa046402.37073955
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36750883
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26760538
10DNA replication_Homo sapiens_hsa030302.24501896
11Antigen processing and presentation_Homo sapiens_hsa046122.20944185
12Ribosome_Homo sapiens_hsa030102.15498259
13Leishmaniasis_Homo sapiens_hsa051402.06488728
14Non-homologous end-joining_Homo sapiens_hsa034501.96348024
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89188251
16Osteoclast differentiation_Homo sapiens_hsa043801.84387096
17Base excision repair_Homo sapiens_hsa034101.84202030
18Herpes simplex infection_Homo sapiens_hsa051681.81340404
19Mismatch repair_Homo sapiens_hsa034301.77404192
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77339841
21Allograft rejection_Homo sapiens_hsa053301.59852111
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54404649
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.53976445
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38933184
25Homologous recombination_Homo sapiens_hsa034401.35848724
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35156641
27Spliceosome_Homo sapiens_hsa030401.30185858
28Acute myeloid leukemia_Homo sapiens_hsa052211.29855214
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29721610
30Graft-versus-host disease_Homo sapiens_hsa053321.27785181
31Chemokine signaling pathway_Homo sapiens_hsa040621.24099690
32Shigellosis_Homo sapiens_hsa051311.23329821
33Rheumatoid arthritis_Homo sapiens_hsa053231.21467763
34Hepatitis B_Homo sapiens_hsa051611.21168386
35Influenza A_Homo sapiens_hsa051641.18505923
36Viral myocarditis_Homo sapiens_hsa054161.14755216
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.13637909
38Toxoplasmosis_Homo sapiens_hsa051451.13320536
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09897096
40Platelet activation_Homo sapiens_hsa046111.06396965
41Nucleotide excision repair_Homo sapiens_hsa034201.06384850
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05948172
43Apoptosis_Homo sapiens_hsa042101.04316390
44Epstein-Barr virus infection_Homo sapiens_hsa051691.01552491
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96152702
46Tuberculosis_Homo sapiens_hsa051520.95334757
47HTLV-I infection_Homo sapiens_hsa051660.94230045
48Other glycan degradation_Homo sapiens_hsa005110.93768972
49Autoimmune thyroid disease_Homo sapiens_hsa053200.92458931
50Fanconi anemia pathway_Homo sapiens_hsa034600.92395523
51RNA degradation_Homo sapiens_hsa030180.89389380
52Pancreatic cancer_Homo sapiens_hsa052120.89059395
53Chronic myeloid leukemia_Homo sapiens_hsa052200.86877811
54TNF signaling pathway_Homo sapiens_hsa046680.86252976
55Legionellosis_Homo sapiens_hsa051340.85865125
56Viral carcinogenesis_Homo sapiens_hsa052030.84379619
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81801372
58p53 signaling pathway_Homo sapiens_hsa041150.80946251
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80101757
60Phagosome_Homo sapiens_hsa041450.77985843
61Pertussis_Homo sapiens_hsa051330.77474915
62Asthma_Homo sapiens_hsa053100.76034028
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75976287
64Pyrimidine metabolism_Homo sapiens_hsa002400.72017315
65Cell cycle_Homo sapiens_hsa041100.71118309
66Hepatitis C_Homo sapiens_hsa051600.70210003
67Malaria_Homo sapiens_hsa051440.70014490
68Non-small cell lung cancer_Homo sapiens_hsa052230.67896124
69Colorectal cancer_Homo sapiens_hsa052100.65722681
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63346410
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61260264
72Salmonella infection_Homo sapiens_hsa051320.61113150
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61043441
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.60602267
75Systemic lupus erythematosus_Homo sapiens_hsa053220.59199478
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57063566
77mRNA surveillance pathway_Homo sapiens_hsa030150.55826864
78Endocytosis_Homo sapiens_hsa041440.55060948
79Staphylococcus aureus infection_Homo sapiens_hsa051500.54493335
80RNA polymerase_Homo sapiens_hsa030200.53780320
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53385173
82Notch signaling pathway_Homo sapiens_hsa043300.52202148
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51616450
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48646663
85Small cell lung cancer_Homo sapiens_hsa052220.48319894
86Prolactin signaling pathway_Homo sapiens_hsa049170.47483640
87RNA transport_Homo sapiens_hsa030130.46981518
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46344648
89Type I diabetes mellitus_Homo sapiens_hsa049400.44834367
90Pentose phosphate pathway_Homo sapiens_hsa000300.43225927
91Regulation of autophagy_Homo sapiens_hsa041400.43082794
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.42866490
93Caffeine metabolism_Homo sapiens_hsa002320.41826173
94Basal transcription factors_Homo sapiens_hsa030220.41645425
95Inositol phosphate metabolism_Homo sapiens_hsa005620.41448494
96Choline metabolism in cancer_Homo sapiens_hsa052310.40120594
97N-Glycan biosynthesis_Homo sapiens_hsa005100.39497999
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.39346543
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39246599
100FoxO signaling pathway_Homo sapiens_hsa040680.39094600
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37348692
102MAPK signaling pathway_Homo sapiens_hsa040100.37227669
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36908371
104African trypanosomiasis_Homo sapiens_hsa051430.36695563
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.36365452
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35753618
107VEGF signaling pathway_Homo sapiens_hsa043700.35658586
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34046101
109One carbon pool by folate_Homo sapiens_hsa006700.33782913
110Proteasome_Homo sapiens_hsa030500.33103807
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32912775
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32555971
113Dorso-ventral axis formation_Homo sapiens_hsa043200.31488416
114Insulin resistance_Homo sapiens_hsa049310.30382980
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29327528
116Thyroid cancer_Homo sapiens_hsa052160.28041726
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.27968023
118Renal cell carcinoma_Homo sapiens_hsa052110.27397816
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24734184
120Lysosome_Homo sapiens_hsa041420.24428533
121Ras signaling pathway_Homo sapiens_hsa040140.22279370
122mTOR signaling pathway_Homo sapiens_hsa041500.22113232
123Endometrial cancer_Homo sapiens_hsa052130.21768730
124GnRH signaling pathway_Homo sapiens_hsa049120.19685317
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19523515
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19234276
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16775881
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.16632762
129HIF-1 signaling pathway_Homo sapiens_hsa040660.14965056
130Arachidonic acid metabolism_Homo sapiens_hsa005900.14742900
131Long-term potentiation_Homo sapiens_hsa047200.13961764

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