TRAF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.57387383
2folic acid-containing compound biosynthetic process (GO:0009396)4.07330364
3DNA unwinding involved in DNA replication (GO:0006268)3.92357924
4proline biosynthetic process (GO:0006561)3.86848718
5regulation of hippo signaling (GO:0035330)3.68537357
6regulation of posttranscriptional gene silencing (GO:0060147)3.61900559
7regulation of gene silencing by miRNA (GO:0060964)3.61900559
8regulation of gene silencing by RNA (GO:0060966)3.61900559
9regulation of mammary gland epithelial cell proliferation (GO:0033599)3.57772244
10COPI coating of Golgi vesicle (GO:0048205)3.57281306
11Golgi transport vesicle coating (GO:0048200)3.57281306
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.54941767
13ribosomal small subunit assembly (GO:0000028)3.52605148
14peptidyl-arginine omega-N-methylation (GO:0035247)3.51777796
15convergent extension (GO:0060026)3.44543069
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40978917
17protein localization to kinetochore (GO:0034501)3.39696353
18adherens junction assembly (GO:0034333)3.36717276
19protein targeting to ER (GO:0045047)3.34218392
20cotranslational protein targeting to membrane (GO:0006613)3.33393558
21pre-miRNA processing (GO:0031054)3.26554187
22negative regulation of RNA splicing (GO:0033119)3.25001908
23cell-substrate adherens junction assembly (GO:0007045)3.22435625
24focal adhesion assembly (GO:0048041)3.22435625
25viral transcription (GO:0019083)3.21916583
26DNA replication-dependent nucleosome organization (GO:0034723)3.21677231
27DNA replication-dependent nucleosome assembly (GO:0006335)3.21677231
28folic acid metabolic process (GO:0046655)3.21602956
29protein complex localization (GO:0031503)3.18842698
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18464026
31activation of Rac GTPase activity (GO:0032863)3.18035859
32semaphorin-plexin signaling pathway (GO:0071526)3.16888755
33establishment of monopolar cell polarity (GO:0061162)3.16513963
34establishment or maintenance of monopolar cell polarity (GO:0061339)3.16513963
35ear development (GO:0043583)3.16335224
36regulation of translational fidelity (GO:0006450)3.15506084
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15156551
38cellular protein complex localization (GO:0034629)3.13809196
39translational termination (GO:0006415)3.13677535
40formation of translation preinitiation complex (GO:0001731)3.10556388
41negative regulation of mRNA processing (GO:0050686)3.08569900
42desmosome organization (GO:0002934)3.08200581
43polarized epithelial cell differentiation (GO:0030859)3.07569795
44mitotic nuclear envelope disassembly (GO:0007077)3.06833344
45glycine metabolic process (GO:0006544)3.02948803
46protein localization to endoplasmic reticulum (GO:0070972)3.02380329
47heterochromatin organization (GO:0070828)3.01092973
48GDP-mannose metabolic process (GO:0019673)3.00466061
49atrioventricular valve morphogenesis (GO:0003181)2.99492344
50regulation of RNA export from nucleus (GO:0046831)2.99313968
51peptidyl-arginine methylation (GO:0018216)2.98558471
52peptidyl-arginine N-methylation (GO:0035246)2.98558471
53translational initiation (GO:0006413)2.98240497
54endothelial cell chemotaxis (GO:0035767)2.96422519
55histone arginine methylation (GO:0034969)2.95277197
56maturation of SSU-rRNA (GO:0030490)2.92446789
57proline metabolic process (GO:0006560)2.88805411
58mitotic metaphase plate congression (GO:0007080)2.88663597
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.88474265
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87807027
61translational elongation (GO:0006414)2.86603960
62regulation of SMAD protein import into nucleus (GO:0060390)2.86596999
63protein localization to chromosome, centromeric region (GO:0071459)2.85440716
64nuclear envelope disassembly (GO:0051081)2.83558576
65membrane disassembly (GO:0030397)2.83558576
66mitotic G1 DNA damage checkpoint (GO:0031571)2.80725626
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.80660612
68ribonucleoprotein complex biogenesis (GO:0022613)2.80518460
69maternal placenta development (GO:0001893)2.79459238
70negative regulation of mRNA metabolic process (GO:1903312)2.77957462
71regulation of NFAT protein import into nucleus (GO:0051532)2.76902473
72regulation of chromatin binding (GO:0035561)2.75949617
73negative regulation of cell fate specification (GO:0009996)2.75346112
74tetrahydrofolate metabolic process (GO:0046653)2.74519367
75establishment of apical/basal cell polarity (GO:0035089)2.74463092
76epithelial cell-cell adhesion (GO:0090136)2.74300314
77branching involved in mammary gland duct morphogenesis (GO:0060444)2.72497201
78intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.72328878
79G1 DNA damage checkpoint (GO:0044783)2.71137410
80Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70784359
81nuclear pore organization (GO:0006999)2.69336098
82planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68467388
83serine family amino acid biosynthetic process (GO:0009070)2.67907994
84ribosomal large subunit biogenesis (GO:0042273)2.67785276
85establishment of integrated proviral latency (GO:0075713)2.67108728
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.66799000
87L-serine metabolic process (GO:0006563)2.66316485
88ribosomal small subunit biogenesis (GO:0042274)2.64080126
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63622457
90regulation of histone H3-K27 methylation (GO:0061085)2.62848444
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61929214
92hippo signaling (GO:0035329)2.61741460
93protein retention in ER lumen (GO:0006621)2.60053577
94mitotic G1/S transition checkpoint (GO:0044819)2.59893354
95positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.59803124
96basement membrane organization (GO:0071711)2.59280641
97activation of MAPKKK activity (GO:0000185)2.59153660
98regulation of spindle organization (GO:0090224)2.59128509
99histone H2A monoubiquitination (GO:0035518)2.57558606
100nuclear envelope reassembly (GO:0031468)2.57364801
101mitotic nuclear envelope reassembly (GO:0007084)2.57364801
102regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57213921
103establishment or maintenance of apical/basal cell polarity (GO:0035088)2.56580313
104establishment or maintenance of bipolar cell polarity (GO:0061245)2.56580313
105DNA strand elongation involved in DNA replication (GO:0006271)2.56543674
106embryonic foregut morphogenesis (GO:0048617)2.56483582
107nucleobase biosynthetic process (GO:0046112)2.56095523
108regulation of nucleobase-containing compound transport (GO:0032239)2.55356755
109folic acid-containing compound metabolic process (GO:0006760)2.53853487
110lens fiber cell development (GO:0070307)2.53037333
111lung morphogenesis (GO:0060425)2.52934645
112regulation of establishment of planar polarity (GO:0090175)2.52661583
113protein targeting to membrane (GO:0006612)2.52488595
114sister chromatid segregation (GO:0000819)2.52366208
115protein complex disassembly (GO:0043241)2.51187395
116nuclear pore complex assembly (GO:0051292)2.50201650
117cell-substrate junction assembly (GO:0007044)2.49222003
118hemidesmosome assembly (GO:0031581)2.48881817
119nuclear-transcribed mRNA catabolic process (GO:0000956)2.48807674
120cellular protein complex disassembly (GO:0043624)2.48450140
121establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48231754
122DNA replication initiation (GO:0006270)2.47665749
123regulation of sister chromatid cohesion (GO:0007063)2.46953970
124mRNA splicing, via spliceosome (GO:0000398)2.46781467
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46781467
126viral life cycle (GO:0019058)2.46566272
127chromosome condensation (GO:0030261)2.46531500
128negative regulation of histone methylation (GO:0031061)2.45231673
129RNA splicing, via transesterification reactions (GO:0000375)2.44282172
130dosage compensation (GO:0007549)2.43210264
131ribosome assembly (GO:0042255)2.42821971
132apoptotic process involved in morphogenesis (GO:0060561)2.42806850
133mitotic sister chromatid segregation (GO:0000070)2.42627444
134notochord development (GO:0030903)2.41882118
135DNA duplex unwinding (GO:0032508)2.41311337
136DNA strand elongation (GO:0022616)2.40379992
137negative regulation of sterol transport (GO:0032372)2.40081234
138negative regulation of cholesterol transport (GO:0032375)2.40081234
139embryonic camera-type eye development (GO:0031076)2.38692323
140protein-DNA complex disassembly (GO:0032986)2.38686875
141nucleosome disassembly (GO:0006337)2.38686875
142spliceosomal snRNP assembly (GO:0000387)2.38611139
143nuclear envelope organization (GO:0006998)2.37792252
144DNA geometric change (GO:0032392)2.36974144
145one-carbon metabolic process (GO:0006730)2.36573925
146lung-associated mesenchyme development (GO:0060484)2.36062048
147regulation of telomere maintenance via telomerase (GO:0032210)2.36020689
148nodal signaling pathway (GO:0038092)2.35642793
149mitotic chromosome condensation (GO:0007076)2.34894908
150chaperone-mediated protein complex assembly (GO:0051131)2.34853800
151protein localization to chromosome (GO:0034502)2.33208972
152serine family amino acid metabolic process (GO:0009069)2.33055399
153collecting duct development (GO:0072044)2.32538840
154mRNA stabilization (GO:0048255)2.32382971
155RNA stabilization (GO:0043489)2.32382971
156regulation of stem cell maintenance (GO:2000036)2.32293464
157metaphase plate congression (GO:0051310)2.32193987
158intracellular estrogen receptor signaling pathway (GO:0030520)2.30880773
159macromolecular complex disassembly (GO:0032984)2.30517617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28810526
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24663223
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.68855542
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33593364
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.90068368
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84920729
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67637131
8* MYC_22102868_ChIP-Seq_BL_Human2.42171694
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.33795231
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33309164
11XRN2_22483619_ChIP-Seq_HELA_Human2.28009495
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25743479
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15037545
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.12344956
15* LXR_22292898_ChIP-Seq_THP-1_Human2.12035088
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04354924
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02888736
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99182810
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95163858
20AR_21909140_ChIP-Seq_LNCAP_Human1.88468138
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84345673
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.82457077
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81077437
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77267473
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77196511
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.75929383
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70181684
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66998862
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.64375586
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63858612
31ZNF263_19887448_ChIP-Seq_K562_Human1.63782412
32CLOCK_20551151_ChIP-Seq_293T_Human1.63605379
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63120174
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60907900
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60334835
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58806677
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58805887
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58243273
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56116575
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56028097
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55605674
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.54968924
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54360543
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52624727
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.51934716
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51180010
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50720382
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50668054
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.47771598
50* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47563777
51TTF2_22483619_ChIP-Seq_HELA_Human1.46336338
52TCF7_22412390_ChIP-Seq_EML_Mouse1.45230704
53* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44857519
54* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44091399
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42969729
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41981410
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40223322
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39783519
59CIITA_25753668_ChIP-Seq_RAJI_Human1.38784688
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38330815
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38113288
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37690673
63KDM2B_26808549_Chip-Seq_K562_Human1.37398052
64OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37250288
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36994044
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36753473
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.36437752
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36108145
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.35951009
70CREB1_26743006_Chip-Seq_LNCaP_Human1.35942522
71VDR_21846776_ChIP-Seq_THP-1_Human1.34737190
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34650483
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34517872
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34517872
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34517872
76KDM5A_27292631_Chip-Seq_BREAST_Human1.32778121
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32758854
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32449959
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32054144
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30193559
81GABP_19822575_ChIP-Seq_HepG2_Human1.29972658
82* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29587505
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29377026
84* ATF3_27146783_Chip-Seq_COLON_Human1.29136897
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28626351
86P68_20966046_ChIP-Seq_HELA_Human1.27103250
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26532705
88* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25305633
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.25227491
90DCP1A_22483619_ChIP-Seq_HELA_Human1.24522473
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.23735968
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23525679
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23354851
94* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22592264
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20879589
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20772770
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18610680
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18134410
99SMC4_20622854_ChIP-Seq_HELA_Human1.17145012
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14623457
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14008081
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13813395
103TP53_22127205_ChIP-Seq_IMR90_Human1.13564410
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12600192
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11822232
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11280587
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11143884
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.10804759
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10642943
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10614236
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10401605
112* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08839450
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08534982
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.08402888
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07611406
116GABP_17652178_ChIP-ChIP_JURKAT_Human1.07351492
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06525254
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06446741
119ESR1_21235772_ChIP-Seq_MCF-7_Human1.06442039
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05183282
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04972439
122POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04968736
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03792348
124* RACK7_27058665_Chip-Seq_MCF-7_Human1.03192760
125CHD1_26751641_Chip-Seq_LNCaP_Human1.03190656
126* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02991229
127SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02855002
128* KDM2B_26808549_Chip-Seq_DND41_Human1.02778578
129* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01422604
130VDR_23849224_ChIP-Seq_CD4+_Human1.01082576
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00520470
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98496853
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98147137
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98104040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.32744407
2MP0000537_abnormal_urethra_morphology3.07209792
3MP0002653_abnormal_ependyma_morphology3.01438560
4MP0003705_abnormal_hypodermis_morpholog2.81985833
5MP0004957_abnormal_blastocyst_morpholog2.73356348
6MP0003693_abnormal_embryo_hatching2.71038674
7MP0003111_abnormal_nucleus_morphology2.56386301
8MP0009053_abnormal_anal_canal2.46775742
9MP0009379_abnormal_foot_pigmentation2.37451492
10MP0003077_abnormal_cell_cycle2.34287842
11MP0010352_gastrointestinal_tract_polyps2.27679899
12MP0002796_impaired_skin_barrier2.10854743
13MP0001730_embryonic_growth_arrest2.07865330
14MP0002139_abnormal_hepatobiliary_system2.04415121
15MP0003119_abnormal_digestive_system2.00532384
16MP0005360_urolithiasis1.95005530
17MP0008932_abnormal_embryonic_tissue1.89375113
18MP0001348_abnormal_lacrimal_gland1.88964639
19MP0010094_abnormal_chromosome_stability1.88883885
20MP0004197_abnormal_fetal_growth/weight/1.86509441
21MP0001849_ear_inflammation1.83738350
22MP0002084_abnormal_developmental_patter1.83064271
23MP0004858_abnormal_nervous_system1.81797095
24MP0001346_abnormal_lacrimal_gland1.81174141
25MP0000350_abnormal_cell_proliferation1.80848203
26MP0003890_abnormal_embryonic-extraembry1.80538786
27MP0005076_abnormal_cell_differentiation1.80115816
28MP0005451_abnormal_body_composition1.77438204
29* MP0002085_abnormal_embryonic_tissue1.77272760
30MP0000579_abnormal_nail_morphology1.76807156
31MP0005380_embryogenesis_phenotype1.73580190
32MP0001672_abnormal_embryogenesis/_devel1.73580190
33MP0008007_abnormal_cellular_replicative1.70835028
34MP0003453_abnormal_keratinocyte_physiol1.64749533
35MP0000678_abnormal_parathyroid_gland1.64488630
36* MP0001697_abnormal_embryo_size1.64183256
37MP0003115_abnormal_respiratory_system1.63282115
38MP0000733_abnormal_muscle_development1.61414742
39MP0003937_abnormal_limbs/digits/tail_de1.60312790
40MP0002088_abnormal_embryonic_growth/wei1.59683493
41MP0003984_embryonic_growth_retardation1.58937639
42MP0002249_abnormal_larynx_morphology1.58346626
43MP0000566_synostosis1.54256217
44MP0002254_reproductive_system_inflammat1.48975251
45MP0003942_abnormal_urinary_system1.48510992
46MP0002086_abnormal_extraembryonic_tissu1.45052081
47MP0004133_heterotaxia1.45002319
48MP0001293_anophthalmia1.42469907
49MP0003123_paternal_imprinting1.42165082
50MP0002092_abnormal_eye_morphology1.41705611
51MP0003806_abnormal_nucleotide_metabolis1.41689167
52MP0010234_abnormal_vibrissa_follicle1.41105774
53MP0002098_abnormal_vibrissa_morphology1.39382928
54* MP0002080_prenatal_lethality1.39072968
55MP0002932_abnormal_joint_morphology1.38900475
56MP0002697_abnormal_eye_size1.37817914
57MP0003567_abnormal_fetal_cardiomyocyte1.33752618
58MP0000428_abnormal_craniofacial_morphol1.32557565
59MP0003315_abnormal_perineum_morphology1.30643725
60MP0009840_abnormal_foam_cell1.27843144
61* MP0002111_abnormal_tail_morphology1.26460472
62MP0005409_darkened_coat_color1.25177935
63MP0001286_abnormal_eye_development1.22492391
64MP0003385_abnormal_body_wall1.22311278
65MP0000003_abnormal_adipose_tissue1.20977718
66MP0005257_abnormal_intraocular_pressure1.19027070
67MP0002102_abnormal_ear_morphology1.18399995
68MP0000534_abnormal_ureter_morphology1.18007018
69MP0000049_abnormal_middle_ear1.15445537
70MP0000490_abnormal_crypts_of1.12799461
71* MP0002089_abnormal_postnatal_growth/wei1.09134631
72* MP0003861_abnormal_nervous_system1.08605811
73MP0010307_abnormal_tumor_latency1.06690271
74MP0001216_abnormal_epidermal_layer1.05607082
75MP0000467_abnormal_esophagus_morphology1.04784114
76MP0001915_intracranial_hemorrhage1.03988049
77MP0000432_abnormal_head_morphology1.03963368
78MP0003935_abnormal_craniofacial_develop1.03932634
79MP0000377_abnormal_hair_follicle1.03391285
80MP0003755_abnormal_palate_morphology1.02509200
81* MP0002282_abnormal_trachea_morphology0.99568742
82MP0003941_abnormal_skin_development0.99511348
83MP0003283_abnormal_digestive_organ0.98050332
84MP0002822_catalepsy0.97796723
85MP0003718_maternal_effect0.96978313
86MP0009672_abnormal_birth_weight0.96265789
87MP0002233_abnormal_nose_morphology0.95841081
88MP0005248_abnormal_Harderian_gland0.95239253
89MP0001340_abnormal_eyelid_morphology0.94587830
90MP0005394_taste/olfaction_phenotype0.94528041
91MP0005499_abnormal_olfactory_system0.94528041
92MP0000627_abnormal_mammary_gland0.94412062
93MP0003938_abnormal_ear_development0.92944111
94MP0000462_abnormal_digestive_system0.92624367
95MP0002116_abnormal_craniofacial_bone0.92579259
96MP0005365_abnormal_bile_salt0.92469296
97MP0002938_white_spotting0.91870260
98MP0005623_abnormal_meninges_morphology0.91838998
99MP0008058_abnormal_DNA_repair0.91452491
100MP0005187_abnormal_penis_morphology0.90896683
101MP0009278_abnormal_bone_marrow0.90692136
102MP0000477_abnormal_intestine_morphology0.90604962
103MP0003136_yellow_coat_color0.90429232
104MP0005377_hearing/vestibular/ear_phenot0.89806355
105MP0003878_abnormal_ear_physiology0.89806355
106MP0005501_abnormal_skin_physiology0.89347425
107MP0005023_abnormal_wound_healing0.88936067
108MP0005508_abnormal_skeleton_morphology0.88086394
109MP0005085_abnormal_gallbladder_physiolo0.87873753
110MP0004264_abnormal_extraembryonic_tissu0.85552099
111MP0004233_abnormal_muscle_weight0.83332814
112MP0009703_decreased_birth_body0.82646785
113MP0001873_stomach_inflammation0.82142753
114MP0005083_abnormal_biliary_tract0.81710258
115MP0003566_abnormal_cell_adhesion0.81599617
116MP0005666_abnormal_adipose_tissue0.81323838
117MP0004272_abnormal_basement_membrane0.79434323
118MP0008260_abnormal_autophagy0.78716252
119MP0002060_abnormal_skin_morphology0.78281451
120MP0009384_cardiac_valve_regurgitation0.77970933
121MP0005375_adipose_tissue_phenotype0.77819210
122MP0004185_abnormal_adipocyte_glucose0.77599066
123MP0005220_abnormal_exocrine_pancreas0.76500116
124MP0002751_abnormal_autonomic_nervous0.75727370
125MP0000762_abnormal_tongue_morphology0.75538079
126MP0009250_abnormal_appendicular_skeleto0.74294934
127MP0008789_abnormal_olfactory_epithelium0.73657068
128MP0002019_abnormal_tumor_incidence0.73541690
129MP0003121_genomic_imprinting0.73256458
130MP0000313_abnormal_cell_death0.72656371

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)2.92132369
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92132369
3Flat acetabular roof (HP:0003180)2.86033029
4Protrusio acetabuli (HP:0003179)2.83915023
5Proximal placement of thumb (HP:0009623)2.81948136
6Deviation of the thumb (HP:0009603)2.79518218
7Abnormality of the 4th metacarpal (HP:0010012)2.75676045
8Partial duplication of thumb phalanx (HP:0009944)2.73643463
9Spastic diplegia (HP:0001264)2.72682275
10Bronchomalacia (HP:0002780)2.60571429
11Multiple enchondromatosis (HP:0005701)2.58438856
12Trismus (HP:0000211)2.56887192
13Ependymoma (HP:0002888)2.56702716
14Ulnar bowing (HP:0003031)2.52670734
15Broad face (HP:0000283)2.52418981
16Pseudobulbar signs (HP:0002200)2.47516013
17Abnormal number of erythroid precursors (HP:0012131)2.41604616
18Partial duplication of the phalanx of hand (HP:0009999)2.40919363
19Cortical dysplasia (HP:0002539)2.39808572
20Selective tooth agenesis (HP:0001592)2.38167973
21Overlapping toe (HP:0001845)2.37952719
22High anterior hairline (HP:0009890)2.36885217
23Rib fusion (HP:0000902)2.35493588
24Patellar aplasia (HP:0006443)2.34044303
25Shallow orbits (HP:0000586)2.33471723
26Colon cancer (HP:0003003)2.32487069
27Hyperacusis (HP:0010780)2.31715227
28Thin bony cortex (HP:0002753)2.31517133
29Pterygium (HP:0001059)2.30589274
30Sparse lateral eyebrow (HP:0005338)2.28784898
31Asymmetry of the thorax (HP:0001555)2.26432656
3211 pairs of ribs (HP:0000878)2.25950926
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.24247670
34Aplasia/Hypoplasia of the patella (HP:0006498)2.23540149
35Nasolacrimal duct obstruction (HP:0000579)2.19361375
36Reticulocytopenia (HP:0001896)2.19187513
37Breast hypoplasia (HP:0003187)2.16993530
38Esophageal atresia (HP:0002032)2.15931885
39Abnormality of the lacrimal duct (HP:0011481)2.15473155
40Achilles tendon contracture (HP:0001771)2.14327713
41Turricephaly (HP:0000262)2.14210470
42Thin ribs (HP:0000883)2.14117832
43Septate vagina (HP:0001153)2.13520942
44Short phalanx of the thumb (HP:0009660)2.12758967
45Hemivertebrae (HP:0002937)2.12646246
46Flattened epiphyses (HP:0003071)2.12168607
47Malignant gastrointestinal tract tumors (HP:0006749)2.10758273
48Gastrointestinal carcinoma (HP:0002672)2.10758273
49Renal duplication (HP:0000075)2.10715087
50Back pain (HP:0003418)2.07526373
51Broad distal phalanx of finger (HP:0009836)2.06541564
52Deep venous thrombosis (HP:0002625)2.06152160
53Increased nuchal translucency (HP:0010880)2.05344559
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05276048
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04964398
56Genu recurvatum (HP:0002816)2.04790556
57Atresia of the external auditory canal (HP:0000413)2.03918641
58Vertebral clefting (HP:0008428)2.03435387
59Vertebral fusion (HP:0002948)2.03347923
60Overriding aorta (HP:0002623)2.02551891
61Squamous cell carcinoma (HP:0002860)2.00378097
62Abnormal number of incisors (HP:0011064)1.99018424
63Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97236499
64Short 1st metacarpal (HP:0010034)1.97236499
65Progressive muscle weakness (HP:0003323)1.96152082
66Abnormality of the astrocytes (HP:0100707)1.95615985
67Astrocytoma (HP:0009592)1.95615985
68Abnormality of the Achilles tendon (HP:0005109)1.94285205
69Angiofibromas (HP:0010615)1.94098657
70Adenoma sebaceum (HP:0009720)1.94098657
71Missing ribs (HP:0000921)1.93156520
72Increased density of long bones (HP:0006392)1.92207168
73Duplication of thumb phalanx (HP:0009942)1.91632301
74Medulloblastoma (HP:0002885)1.91371552
75Skull defect (HP:0001362)1.91091821
76Abnormal cartilage morphology (HP:0002763)1.89232479
77Abnormality of the salivary glands (HP:0010286)1.88706106
78Premature rupture of membranes (HP:0001788)1.87950172
79Abdominal situs inversus (HP:0003363)1.87343734
80Abnormality of abdominal situs (HP:0011620)1.87343734
81Arnold-Chiari malformation (HP:0002308)1.86440140
82Abnormality of the 1st metacarpal (HP:0010009)1.86405403
83Ankyloglossia (HP:0010296)1.85799693
84Disproportionate tall stature (HP:0001519)1.85710628
85Distal lower limb amyotrophy (HP:0008944)1.85437424
86Neoplasm of the pancreas (HP:0002894)1.85374630
87Skin tags (HP:0010609)1.85323896
88Abnormality of the calcaneus (HP:0008364)1.84447606
89Anal stenosis (HP:0002025)1.84249694
90Hypobetalipoproteinemia (HP:0003563)1.83249049
91Short nail (HP:0001799)1.83199455
92Preauricular skin tag (HP:0000384)1.82938912
93Oligodactyly (HP:0012165)1.82178811
94Abnormality of pyrimidine metabolism (HP:0004353)1.81994394
95Choanal stenosis (HP:0000452)1.81878601
96Aplasia involving forearm bones (HP:0009822)1.81860228
97Absent forearm bone (HP:0003953)1.81860228
98Advanced eruption of teeth (HP:0006288)1.81733579
99Absent radius (HP:0003974)1.79997617
100Spinal cord compression (HP:0002176)1.79939328
101Insomnia (HP:0100785)1.78990285
102Neoplasm of striated muscle (HP:0009728)1.78953823
103Progressive external ophthalmoplegia (HP:0000590)1.78861664
104Obstructive sleep apnea (HP:0002870)1.77911619
105Germ cell neoplasia (HP:0100728)1.76396160
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76195846
107Abnormality of the nasolacrimal system (HP:0000614)1.76054582
108Pelvic girdle muscle weakness (HP:0003749)1.75538962
109Self-mutilation (HP:0000742)1.75086503
110Deviation of the hallux (HP:0010051)1.74933098
111Elfin facies (HP:0004428)1.74089274
112Abnormality of the intervertebral disk (HP:0005108)1.73488400
113Wrist flexion contracture (HP:0001239)1.72841885
114Aplasia/hypoplasia of the humerus (HP:0006507)1.71972079
115Abnormal vertebral ossification (HP:0100569)1.71137950
116Spina bifida occulta (HP:0003298)1.71113782
117Down-sloping shoulders (HP:0200021)1.70761633
118Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70656549
119Shawl scrotum (HP:0000049)1.70647688
120Abnormality of reticulocytes (HP:0004312)1.70447592
121Abnormal tarsal ossification (HP:0008369)1.70107900
122Abnormal ossification of hand bones (HP:0005921)1.69210311
123Esophageal varix (HP:0002040)1.69208274
124Rhabdomyosarcoma (HP:0002859)1.69101454
125Ankle contracture (HP:0006466)1.69088173
126Fragile nails (HP:0001808)1.69083976
127Facial cleft (HP:0002006)1.68912158
128Abnormality of the gastric mucosa (HP:0004295)1.68426110
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68176220
130Broad metatarsal (HP:0001783)1.67988717
131Lymphangioma (HP:0100764)1.67305943
132Long eyelashes (HP:0000527)1.66289615
133Biconcave vertebral bodies (HP:0004586)1.66141455
134Abnormality of the anterior horn cell (HP:0006802)1.65956255
135Degeneration of anterior horn cells (HP:0002398)1.65956255
136Pili torti (HP:0003777)1.65158167
137Fibroma (HP:0010614)1.64445321
138Short 5th finger (HP:0009237)1.64404875
139Synostosis of carpal bones (HP:0005048)1.64282064
140Deep palmar crease (HP:0006191)1.62776350
141Hallux valgus (HP:0001822)1.62728850
142Progressive sensorineural hearing impairment (HP:0000408)1.62281233
143Macrocytic anemia (HP:0001972)1.61637406
144Uterine neoplasm (HP:0010784)1.61491699
145Coronal craniosynostosis (HP:0004440)1.61461479
146Lip pit (HP:0100267)1.60749448
147Milia (HP:0001056)1.60335482
148Natal tooth (HP:0000695)1.60321442
149Vertebral arch anomaly (HP:0008438)1.59368190
150Testicular atrophy (HP:0000029)1.58838680
151Large earlobe (HP:0009748)1.58779861
152Megalocornea (HP:0000485)1.58584402
153Gout (HP:0001997)1.58100533
154Abnormality of cells of the erythroid lineage (HP:0012130)1.58069959
155Carpal synostosis (HP:0009702)1.57775479
156Trigonocephaly (HP:0000243)1.57477520
157Rough bone trabeculation (HP:0100670)1.57458491
158Renovascular hypertension (HP:0100817)1.56901134
159Abnormality of the distal phalanges of the toes (HP:0010182)1.56683317
160Calcaneovalgus deformity (HP:0001848)1.55755991
161Abnormality of the thoracic spine (HP:0100711)1.55702025
162Generalized hypotonia (HP:0001290)1.55648350
163Glossoptosis (HP:0000162)1.55542122
164Broad thumb (HP:0011304)1.55286391
165Short humerus (HP:0005792)1.55193270
166Gastrointestinal stroma tumor (HP:0100723)1.55070153
167Poikiloderma (HP:0001029)1.54873361
168Midface retrusion (HP:0011800)1.54830592
169Progressive hearing impairment (HP:0001730)1.53990712
170Fibrous tissue neoplasm (HP:0012316)1.53572428
171Hyperparathyroidism (HP:0000843)1.53063966
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.53039645
173Long palpebral fissure (HP:0000637)1.52624077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.87456981
2EEF2K3.51257840
3MAP3K103.23484458
4EPHA23.21995123
5BUB13.13492331
6TRIB32.85569286
7CDK122.56438029
8PKN22.47331508
9TESK22.32185654
10PRPF4B2.19657593
11MST1R2.10160871
12ICK2.09370563
13TYRO32.05003383
14NEK22.04743357
15NME11.95835304
16CDC71.90484502
17RPS6KB21.89349787
18LATS11.84968062
19DYRK31.83675624
20LATS21.74144575
21WEE11.72132441
22PDGFRA1.67545484
23SIK11.58676790
24VRK21.55106083
25PAK41.55018309
26EPHB21.53887339
27TTK1.51901253
28CDK71.50338638
29PASK1.46206701
30IRAK31.45366294
31FGFR41.39097707
32MAPK151.37336669
33TGFBR11.37001425
34MAP3K81.35143838
35DYRK21.34959018
36PTK61.34874847
37CDK41.32519910
38NEK11.28798777
39PRKD31.27115572
40MTOR1.26827633
41STK101.24192882
42ERBB41.21973229
43RIPK11.17664868
44DYRK1B1.15517006
45TESK11.15303221
46LRRK21.12884597
47KSR11.12128494
48MAP2K21.07784372
49FGFR11.07358894
50AURKB1.06981038
51PLK11.06955114
52RPS6KA41.06502590
53TSSK61.05192986
54TLK11.03365162
55AURKA1.01674858
56SCYL21.01113981
57LIMK10.97862653
58CDK60.97853375
59PAK20.97027743
60TAF10.95627520
61MAP3K90.95379206
62BRD40.93099902
63PTK20.91698019
64CHEK20.91401672
65ERBB20.90516574
66SRPK10.90154110
67PBK0.84852934
68CHEK10.84739321
69ARAF0.84693110
70STK38L0.83595996
71EIF2AK10.83495555
72ILK0.82227130
73BMX0.80998200
74DDR20.80630152
75PRKCI0.78676559
76MKNK10.78337499
77MAPKAPK30.77125398
78BCKDK0.76979956
79NME20.75311373
80SIK20.74518133
81AKT20.74166123
82ERN10.73713082
83MELK0.72946235
84GRK60.72497193
85NTRK10.72387427
86RPS6KA20.72311488
87CDK80.71779078
88ATR0.69373979
89ACVR1B0.68894604
90MARK20.68139983
91LMTK20.66700624
92PRKD20.66631185
93MAPK110.65214209
94PAK10.63602820
95MET0.61239063
96CDK20.60219574
97PDGFRB0.59807894
98BRAF0.59252550
99STK30.59059589
100TAOK20.58652661
101CDK90.58553821
102STK160.57592876
103IRAK20.57555579
104TAOK10.57241547
105MAP3K70.56626920
106ALK0.55788034
107CDC42BPA0.54496737
108KDR0.52826050
109PIM10.52653541
110FGFR20.52492940
111RPS6KA10.50613628
112RPS6KC10.49176130
113RPS6KL10.49176130
114PLK30.49022009
115TTN0.48627286
116CAMK1G0.46618995
117CSNK1E0.45401986
118CDK10.43212549
119MKNK20.41969560
120CAMK1D0.41596240
121MATK0.38779344
122PIM20.38068682
123ATM0.36721119
124MAP3K110.36090263
125PLK40.35984672
126STK240.35950501
127PAK30.34983061
128MAP3K130.34654256
129* CHUK0.34147872
130EPHB10.33947496
131KSR20.33698421
132FLT30.32988295
133PRKG20.32809109
134SIK30.29967306
135RPS6KA60.29611053
136RET0.28702964
137HIPK20.28466155

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.67116418
2One carbon pool by folate_Homo sapiens_hsa006702.61253790
3DNA replication_Homo sapiens_hsa030302.51914187
4RNA transport_Homo sapiens_hsa030132.39168264
5Cell cycle_Homo sapiens_hsa041102.18779441
6Ribosome_Homo sapiens_hsa030102.16697616
7Mismatch repair_Homo sapiens_hsa034302.02507415
8Basal cell carcinoma_Homo sapiens_hsa052171.99133969
9Fructose and mannose metabolism_Homo sapiens_hsa000511.92506467
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91892217
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90200509
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84379645
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73958898
14Bladder cancer_Homo sapiens_hsa052191.68376009
15Base excision repair_Homo sapiens_hsa034101.68109288
16Hippo signaling pathway_Homo sapiens_hsa043901.66426069
17mRNA surveillance pathway_Homo sapiens_hsa030151.64288381
18p53 signaling pathway_Homo sapiens_hsa041151.63324989
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62525755
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61028050
21Selenocompound metabolism_Homo sapiens_hsa004501.60086310
22Biosynthesis of amino acids_Homo sapiens_hsa012301.57164698
23Nucleotide excision repair_Homo sapiens_hsa034201.57110443
24Notch signaling pathway_Homo sapiens_hsa043301.50847833
25Hedgehog signaling pathway_Homo sapiens_hsa043401.50605363
26RNA polymerase_Homo sapiens_hsa030201.49502467
27MicroRNAs in cancer_Homo sapiens_hsa052061.48830180
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45223825
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.42957773
30Vitamin digestion and absorption_Homo sapiens_hsa049771.40509175
31Lysine degradation_Homo sapiens_hsa003101.29309329
32Sulfur relay system_Homo sapiens_hsa041221.28968975
33Chronic myeloid leukemia_Homo sapiens_hsa052201.24352980
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23175188
35Pyrimidine metabolism_Homo sapiens_hsa002401.23059666
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.21062375
37Phenylalanine metabolism_Homo sapiens_hsa003601.19400103
38Proteasome_Homo sapiens_hsa030501.18421065
39ErbB signaling pathway_Homo sapiens_hsa040121.16474418
40Carbon metabolism_Homo sapiens_hsa012001.15934574
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14498968
42* Small cell lung cancer_Homo sapiens_hsa052221.08191640
43Adherens junction_Homo sapiens_hsa045201.07038483
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.05751384
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04856653
46Colorectal cancer_Homo sapiens_hsa052101.04284797
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.02708291
48N-Glycan biosynthesis_Homo sapiens_hsa005101.01377304
49TGF-beta signaling pathway_Homo sapiens_hsa043501.01022942
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00875511
51VEGF signaling pathway_Homo sapiens_hsa043701.00084213
52Galactose metabolism_Homo sapiens_hsa000520.99680054
53Arginine biosynthesis_Homo sapiens_hsa002200.97545316
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.97481509
55HTLV-I infection_Homo sapiens_hsa051660.94245798
56Insulin signaling pathway_Homo sapiens_hsa049100.90608793
57Fat digestion and absorption_Homo sapiens_hsa049750.90254331
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89960351
59Nitrogen metabolism_Homo sapiens_hsa009100.89569454
60Viral carcinogenesis_Homo sapiens_hsa052030.88536049
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87220087
62Thyroid cancer_Homo sapiens_hsa052160.86735015
63Tryptophan metabolism_Homo sapiens_hsa003800.85894967
64Systemic lupus erythematosus_Homo sapiens_hsa053220.84330013
65Hepatitis C_Homo sapiens_hsa051600.83851216
66Folate biosynthesis_Homo sapiens_hsa007900.83762063
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83429425
68Endometrial cancer_Homo sapiens_hsa052130.83236787
69Homologous recombination_Homo sapiens_hsa034400.82330855
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81958157
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81531448
72Pentose phosphate pathway_Homo sapiens_hsa000300.80052787
73Tight junction_Homo sapiens_hsa045300.78682522
74Butanoate metabolism_Homo sapiens_hsa006500.77903123
75RNA degradation_Homo sapiens_hsa030180.77634057
76mTOR signaling pathway_Homo sapiens_hsa041500.76880285
77Proteoglycans in cancer_Homo sapiens_hsa052050.76761641
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.75022001
79Axon guidance_Homo sapiens_hsa043600.73365825
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72750851
81Epstein-Barr virus infection_Homo sapiens_hsa051690.72565995
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72292455
83Fatty acid degradation_Homo sapiens_hsa000710.71338339
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69877004
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68410772
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67624789
87Vitamin B6 metabolism_Homo sapiens_hsa007500.67491342
88Glioma_Homo sapiens_hsa052140.66736458
89B cell receptor signaling pathway_Homo sapiens_hsa046620.66524100
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65774612
91Arginine and proline metabolism_Homo sapiens_hsa003300.65718066
92Hepatitis B_Homo sapiens_hsa051610.64520286
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62895823
94Glutathione metabolism_Homo sapiens_hsa004800.62858106
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62522157
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62365351
97AMPK signaling pathway_Homo sapiens_hsa041520.62099563
98Viral myocarditis_Homo sapiens_hsa054160.60934364
99Non-small cell lung cancer_Homo sapiens_hsa052230.60842064
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60687272
101Basal transcription factors_Homo sapiens_hsa030220.60109462
102Fatty acid metabolism_Homo sapiens_hsa012120.59305035
103Pyruvate metabolism_Homo sapiens_hsa006200.58668288
104Pancreatic cancer_Homo sapiens_hsa052120.58628677
105Prolactin signaling pathway_Homo sapiens_hsa049170.58592109
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58376364
107Wnt signaling pathway_Homo sapiens_hsa043100.56806564
108Prostate cancer_Homo sapiens_hsa052150.55989701
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54565929
110Melanogenesis_Homo sapiens_hsa049160.54474605
111* Pathways in cancer_Homo sapiens_hsa052000.54204409
112Choline metabolism in cancer_Homo sapiens_hsa052310.53683996
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53117121
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52827614
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52069078
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51606269
117Melanoma_Homo sapiens_hsa052180.51320545
118Renal cell carcinoma_Homo sapiens_hsa052110.51197160
119ECM-receptor interaction_Homo sapiens_hsa045120.47815170
120Other glycan degradation_Homo sapiens_hsa005110.47736997
121Fanconi anemia pathway_Homo sapiens_hsa034600.46498195
122Tyrosine metabolism_Homo sapiens_hsa003500.46489576
123Focal adhesion_Homo sapiens_hsa045100.46172108
124Steroid biosynthesis_Homo sapiens_hsa001000.44065726
125Acute myeloid leukemia_Homo sapiens_hsa052210.43557538
126Prion diseases_Homo sapiens_hsa050200.43536275
127PPAR signaling pathway_Homo sapiens_hsa033200.43130345
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42205449
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40717790
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39750379
131Apoptosis_Homo sapiens_hsa042100.37499134

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