TRAF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)6.02277637
2regulation of gamma-delta T cell differentiation (GO:0045586)5.87432475
3negative T cell selection (GO:0043383)5.86733250
4negative regulation of cell killing (GO:0031342)5.66400658
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.66400658
6negative thymic T cell selection (GO:0045060)5.65084582
7antigen processing and presentation of endogenous antigen (GO:0019883)5.62571162
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60670626
9regulation of gamma-delta T cell activation (GO:0046643)5.43534926
10positive thymic T cell selection (GO:0045059)5.27058033
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22730580
12positive T cell selection (GO:0043368)5.05596747
13response to interleukin-15 (GO:0070672)4.96614039
14B cell receptor signaling pathway (GO:0050853)4.93584294
15positive regulation of B cell differentiation (GO:0045579)4.87244492
16regulation of B cell differentiation (GO:0045577)4.70242934
17thymic T cell selection (GO:0045061)4.61268153
18T cell selection (GO:0045058)4.52816804
19positive regulation of granulocyte differentiation (GO:0030854)4.26633376
20regulation of alpha-beta T cell proliferation (GO:0046640)4.24801512
21activated T cell proliferation (GO:0050798)4.20271057
22antigen receptor-mediated signaling pathway (GO:0050851)3.99691828
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.93486230
24regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.92188347
25regulation of regulatory T cell differentiation (GO:0045589)3.89794373
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80815626
27regulation of T cell mediated cytotoxicity (GO:0001914)3.76032876
28G-protein coupled receptor internalization (GO:0002031)3.74697343
29positive regulation of alpha-beta T cell proliferation (GO:0046641)3.73550607
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71673651
31T cell receptor signaling pathway (GO:0050852)3.69953031
32positive regulation of cellular amide metabolic process (GO:0034250)3.59277554
33regulation of B cell receptor signaling pathway (GO:0050855)3.58418652
34tolerance induction (GO:0002507)3.57024602
35mast cell activation (GO:0045576)3.53275352
36regulation of natural killer cell mediated immunity (GO:0002715)3.49332694
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.49332694
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48713727
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.45912564
40antigen processing and presentation via MHC class Ib (GO:0002475)3.43971953
41positive regulation of gamma-delta T cell activation (GO:0046645)3.43904974
42response to host immune response (GO:0052572)3.42238555
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42238555
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.39220400
45detection of other organism (GO:0098543)3.38088309
46cytidine metabolic process (GO:0046087)3.38073763
47cytidine catabolic process (GO:0006216)3.38073763
48cytidine deamination (GO:0009972)3.38073763
49T cell costimulation (GO:0031295)3.37587144
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.35984900
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.33849686
52modulation by symbiont of host immune response (GO:0052553)3.33779796
53positive regulation by symbiont of host defense response (GO:0052509)3.33779796
54modulation by symbiont of host defense response (GO:0052031)3.33779796
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33779796
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33779796
57positive regulation by organism of defense response of other organism involved in symbiotic interact3.33779796
58superoxide metabolic process (GO:0006801)3.32817156
59lymphocyte costimulation (GO:0031294)3.32743348
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29838054
61positive regulation of interleukin-1 beta secretion (GO:0050718)3.23653191
62immunoglobulin mediated immune response (GO:0016064)3.23396947
63negative regulation of T-helper cell differentiation (GO:0045623)3.23045294
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23045294
65Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20515028
66detection of bacterium (GO:0016045)3.20226531
67response to type I interferon (GO:0034340)3.19170402
68regulation of T cell receptor signaling pathway (GO:0050856)3.17646178
69regulation of alpha-beta T cell activation (GO:0046634)3.15089643
70regulation of cell killing (GO:0031341)3.14984045
71negative regulation of alpha-beta T cell activation (GO:0046636)3.13993533
72regulation of T cell tolerance induction (GO:0002664)3.13662562
73cellular response to type I interferon (GO:0071357)3.13310480
74type I interferon signaling pathway (GO:0060337)3.13310480
75positive regulation of cell killing (GO:0031343)3.11995426
76regulation of non-canonical Wnt signaling pathway (GO:2000050)3.10930307
77dendritic cell migration (GO:0036336)3.10029957
78dendritic cell chemotaxis (GO:0002407)3.08784435
79negative regulation of leukocyte mediated immunity (GO:0002704)3.07355508
80neutrophil activation (GO:0042119)3.05606173
81interferon-gamma production (GO:0032609)3.05475985
82positive regulation of antigen processing and presentation (GO:0002579)3.05294237
83regulation of granulocyte differentiation (GO:0030852)3.03794906
84mucosal-associated lymphoid tissue development (GO:0048537)3.03167031
85Peyers patch development (GO:0048541)3.03167031
86positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.02522133
87regulation of activation of Janus kinase activity (GO:0010533)3.02499956
88T cell homeostasis (GO:0043029)3.00299060
89interferon-gamma-mediated signaling pathway (GO:0060333)3.00104657
90response to host (GO:0075136)2.99413065
91response to host defenses (GO:0052200)2.99413065
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99413065
93DNA deamination (GO:0045006)2.99323355
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.99142482
95negative regulation of mast cell activation (GO:0033004)2.98529787
96mature B cell differentiation (GO:0002335)2.98105172
97germinal center formation (GO:0002467)2.96982284
98energy homeostasis (GO:0097009)2.96906866
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.96789286
100positive regulation of natural killer cell mediated immunity (GO:0002717)2.96641351
101polyketide metabolic process (GO:0030638)2.96179533
102doxorubicin metabolic process (GO:0044598)2.96179533
103daunorubicin metabolic process (GO:0044597)2.96179533
104positive regulation of alpha-beta T cell activation (GO:0046635)2.96015061
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95913114
106centriole assembly (GO:0098534)2.95348159
107positive regulation of interleukin-1 secretion (GO:0050716)2.95004434
108negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.94429997
109regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.94086983
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93222231
111regulation of memory T cell differentiation (GO:0043380)2.93051968
112positive regulation of interleukin-2 production (GO:0032743)2.91784601
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.90580649
114regulation of isotype switching to IgG isotypes (GO:0048302)2.89283624
115positive regulation of T cell mediated immunity (GO:0002711)2.88602067
116mesenchymal cell differentiation involved in kidney development (GO:0072161)2.88449272
117mesenchymal cell differentiation involved in renal system development (GO:2001012)2.88449272
118cellular response to interleukin-15 (GO:0071350)2.87506943
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85805819
120actin nucleation (GO:0045010)2.85210230
121regulation of T cell mediated immunity (GO:0002709)2.84956478
122alpha-beta T cell differentiation (GO:0046632)2.84789450
123positive regulation of isotype switching (GO:0045830)2.84650943
124regulation of interleukin-1 beta secretion (GO:0050706)2.83048650
125detection of molecule of bacterial origin (GO:0032490)2.82673908
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.82405375
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79601101
128response to peptidoglycan (GO:0032494)2.77144157
129granulocyte activation (GO:0036230)2.75737120
130negative regulation of granulocyte differentiation (GO:0030853)2.75341691
131meiotic chromosome segregation (GO:0045132)2.74442575
132regulation of antigen processing and presentation (GO:0002577)2.69541861
133B cell proliferation (GO:0042100)2.69311015
134microglial cell activation (GO:0001774)2.64483834
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.63263096
136cellular extravasation (GO:0045123)2.63228125
137regulation of germinal center formation (GO:0002634)2.63100224
138T cell migration (GO:0072678)2.59184925
139response to muramyl dipeptide (GO:0032495)2.58891132
140neutrophil activation involved in immune response (GO:0002283)2.58226103
141cellular response to exogenous dsRNA (GO:0071360)2.56921313
142detection of external biotic stimulus (GO:0098581)2.54892542
143DNA integration (GO:0015074)2.52601853
144mature B cell differentiation involved in immune response (GO:0002313)2.52265164
145positive regulation of smooth muscle cell migration (GO:0014911)2.51992056
146B cell homeostasis (GO:0001782)2.50783475
147histamine secretion (GO:0001821)2.47086818
148positive regulation of heat generation (GO:0031652)2.47068550
149regulation of RIG-I signaling pathway (GO:0039535)2.46474968
150negative regulation of viral genome replication (GO:0045071)2.45670600
151regulation of platelet aggregation (GO:0090330)2.45459398
152myeloid dendritic cell activation (GO:0001773)2.45345539
153histone H3-K36 demethylation (GO:0070544)2.44653386
154regulation of interleukin-8 secretion (GO:2000482)2.43452378
155G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.43059236
156positive regulation of interleukin-1 beta production (GO:0032731)2.42847782
157kinetochore assembly (GO:0051382)2.42387241
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42156930
159lymph node development (GO:0048535)2.41495883
160cellular response to interferon-beta (GO:0035458)2.40275862
161regulation of DNA endoreduplication (GO:0032875)2.39562656
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.36389343
163leukocyte aggregation (GO:0070486)2.34964014
164detection of biotic stimulus (GO:0009595)2.33590195
165regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.32658702
166positive regulation of interferon-alpha production (GO:0032727)2.32319233
167CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31588646
168T-helper cell differentiation (GO:0042093)2.31588646
169regulation of interleukin-1 secretion (GO:0050704)2.31572304
170ganglion development (GO:0061548)2.30889277
171phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.30151284
172macrophage activation involved in immune response (GO:0002281)2.29784031
173mesenchymal cell differentiation (GO:0048762)2.29161863
174positive regulation of defense response to virus by host (GO:0002230)2.29097615
175T cell lineage commitment (GO:0002360)2.27162210
176response to interferon-alpha (GO:0035455)2.26677225
177positive regulation of interleukin-12 production (GO:0032735)2.26068295
178negative regulation of T cell mediated immunity (GO:0002710)2.24466809
179regulation of mast cell activation (GO:0033003)2.24066903
180positive regulation of interleukin-1 production (GO:0032732)2.21439034
181positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.21081375
182positive regulation of interleukin-10 production (GO:0032733)2.21013535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYB_26560356_Chip-Seq_TH2_Human3.50744263
2GBX2_23144817_ChIP-Seq_PC3_Human3.43067521
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25039960
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.10608910
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.84764178
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78102958
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74275288
8MYB_26560356_Chip-Seq_TH1_Human2.71886583
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.67165557
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.60614268
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.58349841
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.55338682
13GATA3_27048872_Chip-Seq_THYMUS_Human2.43806963
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43332978
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38480222
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.37508260
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32496533
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.23448531
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23209692
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.22293193
21* EZH2_27294783_Chip-Seq_NPCs_Mouse2.21568936
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18779041
23MYC_22102868_ChIP-Seq_BL_Human2.14352785
24MAF_26560356_Chip-Seq_TH1_Human2.12896947
25* GATA3_26560356_Chip-Seq_TH2_Human2.12520080
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06708066
27* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.04980680
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04780529
29SPI1_23547873_ChIP-Seq_NB4_Human2.01173846
30* E2F1_18555785_Chip-Seq_ESCs_Mouse2.00297689
31* P53_22387025_ChIP-Seq_ESCs_Mouse2.00088491
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99363920
33* UTX_26944678_Chip-Seq_JUKART_Human1.99279385
34* NANOG_18555785_Chip-Seq_ESCs_Mouse1.99212560
35* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.98798428
36* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.98671044
37* STAT3_18555785_Chip-Seq_ESCs_Mouse1.95869465
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93451305
39* NMYC_18555785_Chip-Seq_ESCs_Mouse1.89006076
40IGF1R_20145208_ChIP-Seq_DFB_Human1.88520360
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88211709
42CIITA_25753668_ChIP-Seq_RAJI_Human1.86274746
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85670599
44* CMYC_18555785_Chip-Seq_ESCs_Mouse1.82153915
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81410362
46* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.81235364
47* P300_18555785_Chip-Seq_ESCs_Mouse1.77521828
48* OCT4_18555785_Chip-Seq_ESCs_Mouse1.74809423
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73794566
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73499042
51* PU1_27457419_Chip-Seq_LIVER_Mouse1.70738689
52* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.70151998
53* SOX2_18555785_Chip-Seq_ESCs_Mouse1.70055383
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68052825
55P300_19829295_ChIP-Seq_ESCs_Human1.65734501
56* ZFX_18555785_Chip-Seq_ESCs_Mouse1.63863396
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.63723351
58* MAF_26560356_Chip-Seq_TH2_Human1.60469331
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58649060
60* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.58403623
61* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.54974470
62* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54247390
63* KLF4_18555785_Chip-Seq_ESCs_Mouse1.53993577
64* CTCF_18555785_Chip-Seq_ESCs_Mouse1.53619219
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53591687
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53361586
67* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52823764
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52061631
69* CRX_20693478_ChIP-Seq_RETINA_Mouse1.52021014
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51510567
71* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.49721190
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.47628427
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47199287
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47194143
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.46568337
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45771881
77* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.44493831
78SPI1_23127762_ChIP-Seq_K562_Human1.44267869
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.41874611
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41551847
81GATA1_22025678_ChIP-Seq_K562_Human1.41168573
82* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40039988
83EWS_26573619_Chip-Seq_HEK293_Human1.39908996
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37867147
85VDR_24763502_ChIP-Seq_THP-1_Human1.36686689
86SMAD4_21799915_ChIP-Seq_A2780_Human1.35334162
87TAF15_26573619_Chip-Seq_HEK293_Human1.35246180
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34543542
89FUS_26573619_Chip-Seq_HEK293_Human1.34381224
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.34023222
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33166607
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31744031
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31619939
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.30432320
95ER_23166858_ChIP-Seq_MCF-7_Human1.29875798
96TP53_18474530_ChIP-ChIP_U2OS_Human1.28881355
97EZH2_22144423_ChIP-Seq_EOC_Human1.27089048
98STAT3_23295773_ChIP-Seq_U87_Human1.25471169
99RUNX_20019798_ChIP-Seq_JUKART_Human1.23459959
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23110399
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22123702
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22123702
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21855532
104KDM2B_26808549_Chip-Seq_REH_Human1.21682828
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19621786
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19544305
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19360608
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18845716
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.17740799
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.16224025
111RNF2_27304074_Chip-Seq_NSC_Mouse1.15753740
112TCF4_23295773_ChIP-Seq_U87_Human1.14908326
113SMRT_27268052_Chip-Seq_Bcells_Human1.14213353
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13071416
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11136049
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10546927
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10341291
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07849633
119VDR_24787735_ChIP-Seq_THP-1_Human1.07773593
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07399963
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05678327
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05527053
123* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04740920
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03688777
125AR_25329375_ChIP-Seq_VCAP_Human1.03059638
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01847422
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01439919
128* PU_27001747_Chip-Seq_BMDM_Mouse1.01388369
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.01122253
130* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99160846
131GATA3_26560356_Chip-Seq_TH1_Human0.98738157
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.98482161
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98439394
134RUNX2_22187159_ChIP-Seq_PCA_Human0.98088490
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97184100
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96699616
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96437928
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96134959
139TCF7_22412390_ChIP-Seq_EML_Mouse0.96133767
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96080281
141SCL_19346495_ChIP-Seq_HPC-7_Human0.96045646
142EGR1_19374776_ChIP-ChIP_THP-1_Human0.95032924
143ZNF274_21170338_ChIP-Seq_K562_Hela0.93312517
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90454768
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89376427
146VDR_21846776_ChIP-Seq_THP-1_Human0.88955502
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88928575
148VDR_23849224_ChIP-Seq_CD4+_Human0.87355151
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.86432254
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83642945
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83580235
152IRF1_19129219_ChIP-ChIP_H3396_Human0.83181535
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82843763
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82000703
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81392497
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81352386
157TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81082609
158GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79947107
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79551237
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76184518
161P300_27268052_Chip-Seq_Bcells_Human0.74064657
162KDM2B_26808549_Chip-Seq_DND41_Human0.70429556
163GATA1_19941827_ChIP-Seq_MEL_Mouse0.70414633
164FOXP3_21729870_ChIP-Seq_TREG_Human0.69616769
165EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69351067
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66471648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.91017129
2MP0001188_hyperpigmentation3.59112282
3MP0001835_abnormal_antigen_presentation3.44664249
4MP0005671_abnormal_response_to2.55054233
5MP0005387_immune_system_phenotype2.46389304
6MP0001790_abnormal_immune_system2.46389304
7MP0002148_abnormal_hypersensitivity_rea2.45681247
8MP0009785_altered_susceptibility_to2.43086049
9MP0000566_synostosis2.39757777
10MP0000015_abnormal_ear_pigmentation2.33712618
11MP0000703_abnormal_thymus_morphology2.27042909
12MP0002102_abnormal_ear_morphology2.25644906
13MP0006292_abnormal_olfactory_placode2.24045543
14MP0009333_abnormal_splenocyte_physiolog2.19397107
15MP0001986_abnormal_taste_sensitivity2.15071299
16MP0002277_abnormal_respiratory_mucosa2.13897431
17MP0002419_abnormal_innate_immunity2.06051543
18MP0003787_abnormal_imprinting2.04948504
19MP0005409_darkened_coat_color2.03909907
20MP0003136_yellow_coat_color2.03102354
21* MP0001800_abnormal_humoral_immune2.02489402
22MP0005171_absent_coat_pigmentation2.00006475
23* MP0002452_abnormal_antigen_presenting1.97360451
24MP0002876_abnormal_thyroid_physiology1.96678131
25MP0003866_abnormal_defecation1.91224631
26MP0005645_abnormal_hypothalamus_physiol1.89164116
27MP0005000_abnormal_immune_tolerance1.88636742
28* MP0002723_abnormal_immune_serum1.85191078
29MP0005025_abnormal_response_to1.84721597
30MP0003724_increased_susceptibility_to1.84027768
31MP0005174_abnormal_tail_pigmentation1.83071903
32MP0009764_decreased_sensitivity_to1.82783094
33MP0009697_abnormal_copulation1.82488016
34MP0004510_myositis1.74309546
35* MP0001819_abnormal_immune_cell1.67775835
36* MP0002420_abnormal_adaptive_immunity1.66124092
37MP0003303_peritoneal_inflammation1.64113503
38MP0006082_CNS_inflammation1.57097643
39MP0003763_abnormal_thymus_physiology1.55059725
40MP0005451_abnormal_body_composition1.51505108
41MP0005670_abnormal_white_adipose1.51379808
42MP0002396_abnormal_hematopoietic_system1.50945793
43MP0003941_abnormal_skin_development1.50554007
44MP0003045_fibrosis1.50329594
45MP0000685_abnormal_immune_system1.48085802
46MP0004947_skin_inflammation1.48063464
47MP0004381_abnormal_hair_follicle1.46948279
48MP0001533_abnormal_skeleton_physiology1.46217018
49MP0003436_decreased_susceptibility_to1.44656398
50MP0008058_abnormal_DNA_repair1.42519473
51MP0008260_abnormal_autophagy1.42334567
52MP0002138_abnormal_hepatobiliary_system1.40663617
53MP0002163_abnormal_gland_morphology1.40602662
54MP0003300_gastrointestinal_ulcer1.39741743
55MP0005646_abnormal_pituitary_gland1.31919501
56MP0000383_abnormal_hair_follicle1.31315317
57MP0005257_abnormal_intraocular_pressure1.30075970
58MP0000490_abnormal_crypts_of1.26973050
59MP0008057_abnormal_DNA_replication1.26101724
60MP0005075_abnormal_melanosome_morpholog1.26012709
61MP0000465_gastrointestinal_hemorrhage1.25723799
62MP0004782_abnormal_surfactant_physiolog1.25204720
63MP0000372_irregular_coat_pigmentation1.24208683
64MP0001873_stomach_inflammation1.23493718
65MP0002998_abnormal_bone_remodeling1.22038105
66MP0010155_abnormal_intestine_physiology1.21584910
67MP0010386_abnormal_urinary_bladder1.21146649
68MP0002928_abnormal_bile_duct1.18324434
69* MP0000716_abnormal_immune_system1.17286601
70MP0002095_abnormal_skin_pigmentation1.17015088
71MP0002006_tumorigenesis1.15599914
72MP0001346_abnormal_lacrimal_gland1.15371673
73MP0005464_abnormal_platelet_physiology1.13762408
74* MP0002398_abnormal_bone_marrow1.12280547
75MP0002933_joint_inflammation1.11238381
76MP0003279_aneurysm1.09082338
77MP0002132_abnormal_respiratory_system1.06882138
78MP0005310_abnormal_salivary_gland1.05085220
79MP0002735_abnormal_chemical_nociception1.05067194
80MP0001845_abnormal_inflammatory_respons1.04948214
81MP0001853_heart_inflammation1.03414547
82MP0008877_abnormal_DNA_methylation1.03407461
83MP0002405_respiratory_system_inflammati1.02971291
84MP0004808_abnormal_hematopoietic_stem0.97462607
85MP0004742_abnormal_vestibular_system0.96986500
86MP0008004_abnormal_stomach_pH0.96934613
87MP0002019_abnormal_tumor_incidence0.96691779
88MP0002009_preneoplasia0.95132304
89MP0005379_endocrine/exocrine_gland_phen0.92671680
90MP0001186_pigmentation_phenotype0.92080301
91MP0004484_altered_response_of0.91683148
92MP0000689_abnormal_spleen_morphology0.91046134
93MP0001851_eye_inflammation0.89276995
94MP0000681_abnormal_thyroid_gland0.87210586
95MP0002166_altered_tumor_susceptibility0.86677510
96MP0000579_abnormal_nail_morphology0.86668798
97MP0001663_abnormal_digestive_system0.84518898
98MP0005503_abnormal_tendon_morphology0.84055194
99MP0002168_other_aberrant_phenotype0.83207301
100* MP0002429_abnormal_blood_cell0.80481581
101MP0001502_abnormal_circadian_rhythm0.80346311
102MP0002638_abnormal_pupillary_reflex0.79821312
103MP0002722_abnormal_immune_system0.77862664
104MP0003183_abnormal_peptide_metabolism0.77671609
105MP0003172_abnormal_lysosome_physiology0.77595321
106MP0002075_abnormal_coat/hair_pigmentati0.76122914
107MP0005390_skeleton_phenotype0.75550372
108MP0000371_diluted_coat_color0.75235319
109MP0003868_abnormal_feces_composition0.75032253
110MP0002938_white_spotting0.74879196
111MP0008995_early_reproductive_senescence0.74703887
112MP0000858_altered_metastatic_potential0.74695739
113MP0000767_abnormal_smooth_muscle0.73069217
114MP0001545_abnormal_hematopoietic_system0.70938625
115MP0005397_hematopoietic_system_phenotyp0.70938625
116MP0003828_pulmonary_edema0.70814650
117MP0009278_abnormal_bone_marrow0.69981537
118MP0008469_abnormal_protein_level0.69108951
119MP0003448_altered_tumor_morphology0.69071940
120MP0006054_spinal_hemorrhage0.65952467
121MP0001348_abnormal_lacrimal_gland0.64393842
122MP0000249_abnormal_blood_vessel0.62461508
123MP0008961_abnormal_basal_metabolism0.60056780
124MP0009763_increased_sensitivity_to0.59679157
125MP0002136_abnormal_kidney_physiology0.59599665
126MP0002693_abnormal_pancreas_physiology0.59247759
127MP0004883_abnormal_blood_vessel0.58542942
128MP0008872_abnormal_physiological_respon0.58512007
129MP0003795_abnormal_bone_structure0.57822095
130MP0003646_muscle_fatigue0.57600350
131MP0000470_abnormal_stomach_morphology0.56046345
132MP0001958_emphysema0.52157474
133MP0005381_digestive/alimentary_phenotyp0.49953690
134MP0001764_abnormal_homeostasis0.49104233
135MP0002254_reproductive_system_inflammat0.47896329
136MP0003252_abnormal_bile_duct0.46122709
137MP0001919_abnormal_reproductive_system0.45806005
138MP0009115_abnormal_fat_cell0.44844470
139MP0009765_abnormal_xenobiotic_induced0.40451846

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.84622007
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.52591419
3Chromsome breakage (HP:0040012)5.04767261
4Abnormality of T cells (HP:0002843)4.66421574
5Severe combined immunodeficiency (HP:0004430)4.11024977
6Prostate neoplasm (HP:0100787)3.90700501
7Recurrent bronchitis (HP:0002837)3.90448812
8Abnormality of T cell physiology (HP:0011840)3.74923477
9Elevated erythrocyte sedimentation rate (HP:0003565)3.73313513
10Pustule (HP:0200039)3.62359426
11Autoimmune hemolytic anemia (HP:0001890)3.53563883
12IgM deficiency (HP:0002850)3.51385647
13Lymphopenia (HP:0001888)3.49391783
14Recurrent abscess formation (HP:0002722)3.47323466
15Gastrointestinal stroma tumor (HP:0100723)3.34985758
16Abnormality of eosinophils (HP:0001879)3.32919236
17Eczematoid dermatitis (HP:0000976)3.32875273
18Abnormality of cells of the lymphoid lineage (HP:0012140)3.26634441
19Febrile seizures (HP:0002373)3.25737665
20Colitis (HP:0002583)3.21200119
21Inflammation of the large intestine (HP:0002037)3.20795520
22Combined immunodeficiency (HP:0005387)3.17432901
23Optic neuritis (HP:0100653)3.16656522
24Retrobulbar optic neuritis (HP:0100654)3.16656522
25Mesomelia (HP:0003027)3.14690695
26Gastrointestinal infarctions (HP:0005244)3.13085119
27Granulocytopenia (HP:0001913)3.09090864
28Stomach cancer (HP:0012126)3.08173712
29Gastrointestinal inflammation (HP:0004386)3.02177153
30Recurrent cutaneous fungal infections (HP:0011370)2.97092995
31Chronic mucocutaneous candidiasis (HP:0002728)2.97092995
32Recurrent bacterial skin infections (HP:0005406)2.96992186
33Abnormality of B cell number (HP:0010975)2.93454601
34Leukocytosis (HP:0001974)2.91425572
35Duplicated collecting system (HP:0000081)2.88507362
36Abnormality of the prostate (HP:0008775)2.84857900
37Spontaneous hematomas (HP:0007420)2.82245934
38Abnormality of the renal collecting system (HP:0004742)2.81933058
39Recurrent fungal infections (HP:0002841)2.80499750
40Recurrent pneumonia (HP:0006532)2.73832108
41IgA deficiency (HP:0002720)2.69522165
42Hypoplasia of the thymus (HP:0000778)2.69284229
43Papilloma (HP:0012740)2.67117844
44Verrucae (HP:0200043)2.67117844
45Clubbing of toes (HP:0100760)2.64616835
46Chronic diarrhea (HP:0002028)2.64513626
47Myositis (HP:0100614)2.61622648
48Renal cortical cysts (HP:0000803)2.58244801
49Hemoptysis (HP:0002105)2.58058326
50Chronic obstructive pulmonary disease (HP:0006510)2.57882245
51Obstructive lung disease (HP:0006536)2.57882245
52Hypoproteinemia (HP:0003075)2.57847742
53Alveolar cell carcinoma (HP:0006519)2.57081978
54Upper limb muscle weakness (HP:0003484)2.52310385
55Lymphoma (HP:0002665)2.51896858
56Mediastinal lymphadenopathy (HP:0100721)2.50536064
57Chronic hepatic failure (HP:0100626)2.48943208
58Chest pain (HP:0100749)2.47487709
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.45772569
60Meningitis (HP:0001287)2.40600097
61Abnormality of the preputium (HP:0100587)2.40579175
62Agammaglobulinemia (HP:0004432)2.38633178
63Abnormality of DNA repair (HP:0003254)2.38517847
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.36521621
65Orchitis (HP:0100796)2.36434321
66Congenital sensorineural hearing impairment (HP:0008527)2.35429341
67Chronic otitis media (HP:0000389)2.34913790
68Abnormality of incisor morphology (HP:0011063)2.32815793
69Viral hepatitis (HP:0006562)2.32523878
70White forelock (HP:0002211)2.31975435
71Gingivitis (HP:0000230)2.30832321
72Recurrent lower respiratory tract infections (HP:0002783)2.28870273
73Recurrent gram-negative bacterial infections (HP:0005420)2.28826321
74Lip pit (HP:0100267)2.28746243
75B lymphocytopenia (HP:0010976)2.28670000
76Vasculitis (HP:0002633)2.27564603
77Cellulitis (HP:0100658)2.27192880
78Patchy hypopigmentation of hair (HP:0011365)2.26984460
79Tubulointerstitial nephritis (HP:0001970)2.25421162
80Bronchitis (HP:0012387)2.25047238
81Septo-optic dysplasia (HP:0100842)2.24873818
82Recurrent skin infections (HP:0001581)2.23750340
83Neoplasm of the tracheobronchial system (HP:0100552)2.23177116
84Thyroiditis (HP:0100646)2.22743150
85Basal cell carcinoma (HP:0002671)2.20373067
86Abnormality of chromosome stability (HP:0003220)2.19703827
87Reduced antithrombin III activity (HP:0001976)2.19127348
88Panhypogammaglobulinemia (HP:0003139)2.16629783
89Aplasia cutis congenita (HP:0001057)2.15500056
90Increased IgE level (HP:0003212)2.14906752
91Emphysema (HP:0002097)2.14004135
92Meckel diverticulum (HP:0002245)2.13677689
93Abnormality of the pleura (HP:0002103)2.13538843
94Ectopic kidney (HP:0000086)2.10506081
95Fair hair (HP:0002286)2.10418355
96Hypothermia (HP:0002045)2.08604523
97Increased IgM level (HP:0003496)2.08017038
98Median cleft lip (HP:0000161)2.07463213
99Congenital stationary night blindness (HP:0007642)2.07128786
100Papilledema (HP:0001085)2.06963319
101Basal ganglia calcification (HP:0002135)2.06804692
102Osteomyelitis (HP:0002754)2.06692462
103Abnormality of the nasal septum (HP:0000419)2.06620552
104Abnormality of the ileum (HP:0001549)2.03890638
105Prolonged bleeding time (HP:0003010)2.03772455
106Decreased central vision (HP:0007663)2.02416530
107Hypochromic anemia (HP:0001931)1.99286705
108Eosinophilia (HP:0001880)1.98006824
109Recurrent viral infections (HP:0004429)1.94177708
110Restrictive lung disease (HP:0002091)1.94095146
111Distal lower limb muscle weakness (HP:0009053)1.93294391
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92473733
113Absent frontal sinuses (HP:0002688)1.92337704
114Autoimmune thrombocytopenia (HP:0001973)1.92078130
115Premature loss of primary teeth (HP:0006323)1.92057687
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.91758679
117Hypoplasia of the fovea (HP:0007750)1.91758679
118Pulmonary embolism (HP:0002204)1.89933801
119Recurrent sinusitis (HP:0011108)1.89771916
120Tetany (HP:0001281)1.89186216
121Encephalitis (HP:0002383)1.88461678
122Sepsis (HP:0100806)1.88016408
123Arterial thrombosis (HP:0004420)1.87951528
124Spondylolisthesis (HP:0003302)1.85780664
125Hypergammaglobulinemia (HP:0010702)1.85722359
126Hypergonadotropic hypogonadism (HP:0000815)1.85391809
127Abnormality of the renal cortex (HP:0011035)1.83764483
128Abnormality of the peritoneum (HP:0002585)1.83210507
129Conical tooth (HP:0000698)1.83024934
130Protruding tongue (HP:0010808)1.82959274
131Generalized hypopigmentation of hair (HP:0011358)1.82448363
132Attenuation of retinal blood vessels (HP:0007843)1.82130044
133Hematochezia (HP:0002573)1.81923068
134Abnormal ciliary motility (HP:0012262)1.81126547
135Pulmonary infiltrates (HP:0002113)1.81005739
136Congenital hepatic fibrosis (HP:0002612)1.80639580
137Syringomyelia (HP:0003396)1.79290339
138Spinal cord lesions (HP:0100561)1.79290339
139Keratoconjunctivitis sicca (HP:0001097)1.79277050
140Stomatitis (HP:0010280)1.79093250
141Cheilitis (HP:0100825)1.77386258
142Epistaxis (HP:0000421)1.77191891
143Abnormality of T cell number (HP:0011839)1.75228882
144Leukopenia (HP:0001882)1.75157543
145Ectropion (HP:0000656)1.74431303
146Abnormality of the fingertips (HP:0001211)1.74303287
147Neonatal hypoglycemia (HP:0001998)1.74263709
148Chronic sinusitis (HP:0011109)1.73361958
149Abnormality of male internal genitalia (HP:0000022)1.72924752
150Abnormal hair whorl (HP:0010721)1.72746809
151Abnormality of macrophages (HP:0004311)1.70007380
152Keratoconjunctivitis (HP:0001096)1.69842706
153Periodontitis (HP:0000704)1.69775106
154Postaxial foot polydactyly (HP:0001830)1.69685906
155True hermaphroditism (HP:0010459)1.69138295
156Abnormality of the carotid arteries (HP:0005344)1.68900097
157IgG deficiency (HP:0004315)1.68762691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.45784297
2IRAK33.23994060
3CASK3.18086082
4TXK3.17463471
5IRAK42.70301914
6EIF2AK22.60912709
7ZAK2.49957115
8TNIK2.43424548
9INSRR2.08417168
10SIK32.06091505
11GRK62.02952050
12ZAP702.00570118
13TEC1.78234551
14IKBKE1.72004926
15YES11.69689487
16RIPK41.66739895
17IKBKB1.62434670
18ADRBK21.59378355
19JAK11.56884727
20GRK11.52422381
21JAK31.50551359
22NUAK11.49526676
23MKNK21.48345653
24PRPF4B1.47490267
25TGFBR21.47246188
26BMPR21.44084001
27STK161.43920751
28FRK1.35365291
29IRAK11.35010515
30NLK1.31836606
31BLK1.31637387
32GRK71.27453435
33MAP3K101.23564063
34MUSK1.22832456
35BRD41.21642648
36CDK31.20445764
37TBK11.18556286
38MAP4K11.17438419
39KIT1.17242746
40MAP2K71.12477266
41CLK11.11729471
42EPHA31.10963826
43PIK3CG1.08536723
44CHUK1.04741448
45SGK21.04648260
46ERN11.04467937
47TLK11.04427869
48PASK1.02221261
49ACVR1B1.00882344
50TNK20.99782513
51LYN0.95663250
52FGFR40.94900209
53MELK0.93459348
54SYK0.93362653
55BTK0.90364916
56NEK60.89184947
57STK38L0.88979201
58BMPR1B0.88727231
59TRPM70.87674094
60MAP3K130.86726239
61TYK20.85633123
62CSF1R0.84878455
63TAOK30.84083447
64MAPK110.83809577
65MAP3K70.83089538
66MAP4K20.79550430
67CDK40.78441804
68KDR0.76862888
69CAMK1D0.76432039
70MKNK10.75151769
71HCK0.74949071
72CDC42BPA0.74850123
73CAMKK20.74359695
74STK240.73434031
75LCK0.73166351
76CDK80.72987097
77ITK0.72936411
78ERBB30.71596793
79MAPK70.70447769
80STK40.69894137
81OBSCN0.69403869
82MAPK130.69100951
83MAP2K20.68545016
84AKT30.66314356
85PIM10.65675063
86TAOK20.65490940
87JAK20.65251541
88IRAK20.65207771
89RPS6KA40.65202485
90EIF2AK30.65043969
91PLK40.65024481
92STK30.64067362
93SRPK10.64037209
94ATR0.62971695
95HIPK20.62670628
96PBK0.60989810
97STK100.60683651
98PIK3CA0.58995624
99PDK10.58747763
100CSK0.58242214
101FGFR30.57387999
102MAPKAPK30.56504312
103PRKCE0.56134592
104MAP2K30.55241343
105SIK20.55075681
106NME20.54952474
107CAMKK10.54183017
108MAP2K60.53337365
109PRKCQ0.52238276
110OXSR10.50666188
111PKN10.50643194
112CDK190.50384061
113SGK30.48695060
114SGK10.47047291
115PRKCH0.46983394
116PRKAA20.46577123
117CDK90.46454695
118VRK10.45615545
119FYN0.44737947
120NEK90.44632300
121CDK120.43753914
122PRKD20.43150736
123ABL10.42788227
124IGF1R0.42623664
125WNK40.41656748
126MARK30.41288177
127NTRK30.41073208
128TIE10.41056781
129MATK0.39121828
130WNK10.39035864
131PRKCD0.38491788
132FES0.38324589
133STK390.38232962
134PLK20.37638714
135FGR0.37016531
136MAP3K50.36645282
137INSR0.35120706
138ADRBK10.34651773
139MAPK30.34081628
140MAPK120.34030568
141EGFR0.33862390
142MAPKAPK20.33148605
143EPHB10.32328190
144RPS6KA60.31417247
145FLT30.30996904
146CDK60.30760978
147PTK2B0.29934968

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.47699858
2Graft-versus-host disease_Homo sapiens_hsa053322.44977693
3Primary immunodeficiency_Homo sapiens_hsa053402.43831870
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39418901
5* NF-kappa B signaling pathway_Homo sapiens_hsa040642.35847575
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35560990
7Allograft rejection_Homo sapiens_hsa053302.17496981
8Hematopoietic cell lineage_Homo sapiens_hsa046402.14106153
9Fanconi anemia pathway_Homo sapiens_hsa034602.06129410
10Measles_Homo sapiens_hsa051621.99362121
11Autoimmune thyroid disease_Homo sapiens_hsa053201.97583867
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93297821
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90382804
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.87740067
15Leishmaniasis_Homo sapiens_hsa051401.83412535
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81479344
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73037530
18Osteoclast differentiation_Homo sapiens_hsa043801.61611896
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56877460
20Malaria_Homo sapiens_hsa051441.56648785
21Rheumatoid arthritis_Homo sapiens_hsa053231.55013426
22Non-homologous end-joining_Homo sapiens_hsa034501.52482077
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39450600
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.36187059
25Asthma_Homo sapiens_hsa053101.36117279
26Homologous recombination_Homo sapiens_hsa034401.35123169
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34279766
28* Herpes simplex infection_Homo sapiens_hsa051681.33962902
29Influenza A_Homo sapiens_hsa051641.30570083
30* TNF signaling pathway_Homo sapiens_hsa046681.28378848
31African trypanosomiasis_Homo sapiens_hsa051431.23517958
32B cell receptor signaling pathway_Homo sapiens_hsa046621.20916849
33Staphylococcus aureus infection_Homo sapiens_hsa051501.14931762
34Chemokine signaling pathway_Homo sapiens_hsa040621.14737641
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13314577
36Vitamin digestion and absorption_Homo sapiens_hsa049771.13165202
37Sphingolipid metabolism_Homo sapiens_hsa006001.11646377
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10770380
39Type I diabetes mellitus_Homo sapiens_hsa049401.09728967
40Tuberculosis_Homo sapiens_hsa051521.08864379
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08156649
42Other glycan degradation_Homo sapiens_hsa005111.06307379
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02976381
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99778730
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95115728
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.94835516
47Phagosome_Homo sapiens_hsa041450.91429513
48Legionellosis_Homo sapiens_hsa051340.90624075
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90587969
50Nicotine addiction_Homo sapiens_hsa050330.89747066
51T cell receptor signaling pathway_Homo sapiens_hsa046600.88918913
52Arachidonic acid metabolism_Homo sapiens_hsa005900.87712200
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85573951
54ABC transporters_Homo sapiens_hsa020100.85568561
55Phototransduction_Homo sapiens_hsa047440.85451569
56* Epstein-Barr virus infection_Homo sapiens_hsa051690.84655400
57Inositol phosphate metabolism_Homo sapiens_hsa005620.84085309
58Pertussis_Homo sapiens_hsa051330.81242637
59Morphine addiction_Homo sapiens_hsa050320.80868825
60Toxoplasmosis_Homo sapiens_hsa051450.80704899
61Hepatitis B_Homo sapiens_hsa051610.78867070
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75785904
63Apoptosis_Homo sapiens_hsa042100.73290021
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73003870
65Hepatitis C_Homo sapiens_hsa051600.72864783
66Non-small cell lung cancer_Homo sapiens_hsa052230.72034642
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70833142
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69935407
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68632070
70Linoleic acid metabolism_Homo sapiens_hsa005910.65985334
71Taste transduction_Homo sapiens_hsa047420.65058365
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.63737618
73Dorso-ventral axis formation_Homo sapiens_hsa043200.62736109
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61066640
75Basal transcription factors_Homo sapiens_hsa030220.58796260
76Regulation of autophagy_Homo sapiens_hsa041400.56023354
77Calcium signaling pathway_Homo sapiens_hsa040200.55688342
78Shigellosis_Homo sapiens_hsa051310.55531250
79Salmonella infection_Homo sapiens_hsa051320.55247812
80Ether lipid metabolism_Homo sapiens_hsa005650.53875294
81Ovarian steroidogenesis_Homo sapiens_hsa049130.53392953
82p53 signaling pathway_Homo sapiens_hsa041150.51651746
83ECM-receptor interaction_Homo sapiens_hsa045120.51192700
84Pancreatic cancer_Homo sapiens_hsa052120.49995942
85* Viral carcinogenesis_Homo sapiens_hsa052030.49651477
86Base excision repair_Homo sapiens_hsa034100.48563830
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46361650
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.45790912
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.44388134
90Antigen processing and presentation_Homo sapiens_hsa046120.43824632
91FoxO signaling pathway_Homo sapiens_hsa040680.43076242
92Choline metabolism in cancer_Homo sapiens_hsa052310.42649325
93RNA degradation_Homo sapiens_hsa030180.42423105
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.41550722
95Retinol metabolism_Homo sapiens_hsa008300.41304376
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41134768
97Platelet activation_Homo sapiens_hsa046110.40801541
98Chronic myeloid leukemia_Homo sapiens_hsa052200.40644945
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40128196
100Melanoma_Homo sapiens_hsa052180.38974380
101Protein digestion and absorption_Homo sapiens_hsa049740.38758258
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38693488
103HTLV-I infection_Homo sapiens_hsa051660.38601130
104Viral myocarditis_Homo sapiens_hsa054160.37999552
105Insulin resistance_Homo sapiens_hsa049310.36273440
106Acute myeloid leukemia_Homo sapiens_hsa052210.34860002
107MAPK signaling pathway_Homo sapiens_hsa040100.34413736
108Caffeine metabolism_Homo sapiens_hsa002320.32326381
109Olfactory transduction_Homo sapiens_hsa047400.32134367
110Prostate cancer_Homo sapiens_hsa052150.31520220
111Circadian rhythm_Homo sapiens_hsa047100.31410030
112Systemic lupus erythematosus_Homo sapiens_hsa053220.31150126
113Prolactin signaling pathway_Homo sapiens_hsa049170.30808182
114Ras signaling pathway_Homo sapiens_hsa040140.30574694
115Serotonergic synapse_Homo sapiens_hsa047260.29870781
116Glycerolipid metabolism_Homo sapiens_hsa005610.29379344
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29078927
118VEGF signaling pathway_Homo sapiens_hsa043700.28581717
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28523292
120cAMP signaling pathway_Homo sapiens_hsa040240.28500219
121* Small cell lung cancer_Homo sapiens_hsa052220.28254587
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27994319
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.27994082
124Colorectal cancer_Homo sapiens_hsa052100.27647420
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.26075903
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25896540
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.23582896
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21591799
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.21261264
130mTOR signaling pathway_Homo sapiens_hsa041500.18664204
131Endocytosis_Homo sapiens_hsa041440.17087395

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