TRAF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cytokine production involved in inflammatory response (GO:1900015)7.20501625
2positive regulation of gamma-delta T cell activation (GO:0046645)5.57757793
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46772461
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46772461
5antigen processing and presentation of endogenous antigen (GO:0019883)5.23914208
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02843609
7regulation of gamma-delta T cell differentiation (GO:0045586)4.78815014
8NIK/NF-kappaB signaling (GO:0038061)4.61207291
9* positive regulation of osteoclast differentiation (GO:0045672)4.59644595
10regulation of heat generation (GO:0031650)4.44776674
11regulation of gamma-delta T cell activation (GO:0046643)4.40591223
12establishment of protein localization to Golgi (GO:0072600)4.40154650
13protein targeting to Golgi (GO:0000042)4.33355851
14retrograde transport, vesicle recycling within Golgi (GO:0000301)4.18620093
15growth hormone receptor signaling pathway (GO:0060396)4.13075096
16Arp2/3 complex-mediated actin nucleation (GO:0034314)4.09043520
17negative T cell selection (GO:0043383)4.07379555
18* regulation of interleukin-12 biosynthetic process (GO:0045075)4.06102981
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.03141250
20negative thymic T cell selection (GO:0045060)4.01675119
21positive regulation of prostaglandin secretion (GO:0032308)3.94202980
22neural tube formation (GO:0001841)3.91379947
23positive regulation of natural killer cell differentiation (GO:0032825)3.88788280
24regulation of fever generation (GO:0031620)3.86943711
25DNA double-strand break processing (GO:0000729)3.83201851
26regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.81173527
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.78750467
28positive regulation of B cell differentiation (GO:0045579)3.72300140
29positive regulation of granulocyte differentiation (GO:0030854)3.67988492
30positive regulation of heat generation (GO:0031652)3.67622459
31actin nucleation (GO:0045010)3.59987586
32cellular response to growth hormone stimulus (GO:0071378)3.50897721
33negative regulation of thymocyte apoptotic process (GO:0070244)3.49606824
34protein localization to Golgi apparatus (GO:0034067)3.40783501
35regulation of interleukin-8 biosynthetic process (GO:0045414)3.40684257
36protein polyglutamylation (GO:0018095)3.38923966
37alpha-beta T cell differentiation (GO:0046632)3.36763620
38response to interleukin-15 (GO:0070672)3.36055449
39T cell selection (GO:0045058)3.35898200
40regulation of alpha-beta T cell proliferation (GO:0046640)3.33131254
41activated T cell proliferation (GO:0050798)3.31973318
42positive thymic T cell selection (GO:0045059)3.31102042
43* myeloid dendritic cell differentiation (GO:0043011)3.29325935
44regulation of T cell tolerance induction (GO:0002664)3.28612686
45natural killer cell differentiation (GO:0001779)3.28182163
46tyrosine phosphorylation of STAT protein (GO:0007260)3.25695005
47negative regulation of T-helper cell differentiation (GO:0045623)3.24936754
48negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24936754
49thymic T cell selection (GO:0045061)3.23734568
50* regulation of interleukin-6 biosynthetic process (GO:0045408)3.22880831
51regulation of interferon-beta biosynthetic process (GO:0045357)3.17428446
52regulation of cilium movement (GO:0003352)3.16641753
53* myeloid dendritic cell activation (GO:0001773)3.14593934
54positive regulation of interferon-alpha production (GO:0032727)3.13663456
55mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.11308126
56positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.11308126
57regulation of B cell differentiation (GO:0045577)3.11068829
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10382869
59regulation of prostaglandin secretion (GO:0032306)3.10007135
60regulation of interferon-alpha production (GO:0032647)3.09120750
61response to muramyl dipeptide (GO:0032495)3.08915785
62tolerance induction (GO:0002507)3.07979704
63protein-cofactor linkage (GO:0018065)3.07506541
64* positive regulation of interleukin-2 production (GO:0032743)3.03562853
65neutrophil activation involved in immune response (GO:0002283)3.01160919
66regulation of interleukin-2 biosynthetic process (GO:0045076)3.00902443
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97106114
68negative regulation of cell killing (GO:0031342)2.97106114
69* positive regulation of myeloid leukocyte differentiation (GO:0002763)2.95820775
70neutrophil activation (GO:0042119)2.91329000
71positive T cell selection (GO:0043368)2.89096300
72negative regulation of DNA recombination (GO:0045910)2.88539351
73interferon-gamma production (GO:0032609)2.88452416
74regulation of fibroblast apoptotic process (GO:2000269)2.87054948
75negative regulation of T cell mediated immunity (GO:0002710)2.86403518
76thrombin receptor signaling pathway (GO:0070493)2.86011362
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84738783
78adaptation of signaling pathway (GO:0023058)2.84438418
79granulocyte activation (GO:0036230)2.83090680
80positive regulation of histone deacetylation (GO:0031065)2.82795783
81CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.82478614
82T-helper cell differentiation (GO:0042093)2.82478614
83response to lipoprotein particle (GO:0055094)2.82221892
84regulation of natural killer cell differentiation (GO:0032823)2.81510050
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81042695
86positive regulation of humoral immune response (GO:0002922)2.80942659
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80438885
88T cell homeostasis (GO:0043029)2.80185713
89lymph node development (GO:0048535)2.78357817
90hepatocyte apoptotic process (GO:0097284)2.77424355
91somite development (GO:0061053)2.76374927
92B cell receptor signaling pathway (GO:0050853)2.75810651
93protein targeting to lysosome (GO:0006622)2.74778454
94establishment of protein localization to vacuole (GO:0072666)2.74778454
95protein targeting to vacuole (GO:0006623)2.74778454
96interleukin-6-mediated signaling pathway (GO:0070102)2.73219291
97response to type I interferon (GO:0034340)2.72862478
98positive regulation of defense response to virus by host (GO:0002230)2.72817924
99germ cell migration (GO:0008354)2.70902571
100regulation of germinal center formation (GO:0002634)2.70734359
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70153052
102T cell migration (GO:0072678)2.69854321
103regulation of B cell receptor signaling pathway (GO:0050855)2.69484998
104mature B cell differentiation (GO:0002335)2.67271663
105negative regulation of interleukin-10 production (GO:0032693)2.66569567
106natural killer cell activation (GO:0030101)2.66530143
107T cell costimulation (GO:0031295)2.66248185
108peptidyl-threonine dephosphorylation (GO:0035970)2.65692043
109negative regulation of adaptive immune response (GO:0002820)2.65208186
110type I interferon signaling pathway (GO:0060337)2.64703449
111cellular response to type I interferon (GO:0071357)2.64703449
112cellular response to interleukin-15 (GO:0071350)2.63948820
113negative regulation of alpha-beta T cell differentiation (GO:0046639)2.63649773
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63383364
115DNA deamination (GO:0045006)2.63123424
116antigen processing and presentation via MHC class Ib (GO:0002475)2.62004540
117intra-Golgi vesicle-mediated transport (GO:0006891)2.61971876
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61260997
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.61260997
120modulation by symbiont of host immune response (GO:0052553)2.61260997
121positive regulation by symbiont of host defense response (GO:0052509)2.61260997
122modulation by symbiont of host defense response (GO:0052031)2.61260997
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61260997
124mucosal-associated lymphoid tissue development (GO:0048537)2.60865416
125Peyers patch development (GO:0048541)2.60865416
126lymphocyte costimulation (GO:0031294)2.60278682
127cytoplasmic mRNA processing body assembly (GO:0033962)2.59191927
128negative regulation of T cell apoptotic process (GO:0070233)2.59177710
129regulation of chronic inflammatory response (GO:0002676)2.59128883
130leukocyte aggregation (GO:0070486)2.59006056
131positive regulation of isotype switching (GO:0045830)2.58999184
132response to xenobiotic stimulus (GO:0009410)2.58579350
133regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.58402775
134negative regulation of erythrocyte differentiation (GO:0045647)2.57142626
135* dendritic cell differentiation (GO:0097028)2.56625333
136regulation of hypersensitivity (GO:0002883)2.55822238
137cerebral cortex radially oriented cell migration (GO:0021799)2.55696739
138T cell proliferation (GO:0042098)2.53876439
139DNA demethylation (GO:0080111)2.53604841
140iron-sulfur cluster assembly (GO:0016226)2.53243593
141metallo-sulfur cluster assembly (GO:0031163)2.53243593
142lymphocyte homeostasis (GO:0002260)2.52262201
143regulation of tolerance induction (GO:0002643)2.52026418
144water-soluble vitamin biosynthetic process (GO:0042364)2.51409730
145regulation of necroptotic process (GO:0060544)2.50681001
146protein K11-linked deubiquitination (GO:0035871)2.50561246
147positive regulation of interleukin-1 beta secretion (GO:0050718)2.48844775
148regulation of T-helper 1 cell differentiation (GO:0045625)2.48635930
149positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.48583695
150cytokine biosynthetic process (GO:0042089)2.47064840
151phospholipid homeostasis (GO:0055091)2.46546447
152JAK-STAT cascade (GO:0007259)2.46388583
153* positive regulation of cytokine biosynthetic process (GO:0042108)2.46323445
154regulation of feeding behavior (GO:0060259)2.46229109
155histone H3-K4 trimethylation (GO:0080182)2.46211717
156alpha-beta T cell activation (GO:0046631)2.46138876
157necroptotic process (GO:0070266)2.45934546
158alpha-beta T cell differentiation involved in immune response (GO:0002293)2.44151450
159alpha-beta T cell activation involved in immune response (GO:0002287)2.44151450
160T cell differentiation involved in immune response (GO:0002292)2.44151450
161protein deneddylation (GO:0000338)2.44102522
162regulation of skeletal muscle cell differentiation (GO:2001014)2.44102115
163interferon-gamma-mediated signaling pathway (GO:0060333)2.44063560
164negative regulation of B cell proliferation (GO:0030889)2.43278042
165regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42377600
166positive regulation of icosanoid secretion (GO:0032305)2.42245694
167defense response to protozoan (GO:0042832)2.41338819
168* positive regulation of interleukin-12 production (GO:0032735)2.41093753
169regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40915661
170negative regulation of interleukin-1 beta production (GO:0032691)2.40059246
171positive regulation of bone remodeling (GO:0046852)2.39993501
172positive regulation of bone resorption (GO:0045780)2.39993501
173negative regulation of systemic arterial blood pressure (GO:0003085)2.39723173
174positive regulation of antigen processing and presentation (GO:0002579)2.39426859
175regulation of natural killer cell mediated immunity (GO:0002715)2.39364852
176intracellular lipid transport (GO:0032365)2.39355757
177negative regulation of lymphocyte mediated immunity (GO:0002707)2.38798451
178cullin deneddylation (GO:0010388)2.36391444
179positive regulation of fatty acid transport (GO:2000193)2.34308091
180RNA destabilization (GO:0050779)2.32169765
181regulation of interleukin-1 beta secretion (GO:0050706)2.32117599
182B cell homeostasis (GO:0001782)2.31270698
183regulation of memory T cell differentiation (GO:0043380)2.29900228
184cytidine catabolic process (GO:0006216)2.29230598
185cytidine deamination (GO:0009972)2.29230598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.39890461
2E2F7_22180533_ChIP-Seq_HELA_Human4.83570046
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.49348218
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.23131627
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.18712162
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68532299
7ZNF274_21170338_ChIP-Seq_K562_Hela3.40100751
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17781752
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.12491848
10MYC_22102868_ChIP-Seq_BL_Human3.09499053
11FLI1_27457419_Chip-Seq_LIVER_Mouse3.04807544
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.92741969
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88191798
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.85780653
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84579089
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75375487
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72449848
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68952330
19IGF1R_20145208_ChIP-Seq_DFB_Human2.62169781
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60161857
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55482370
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.53455350
23* RUNX_20019798_ChIP-Seq_JUKART_Human2.49164761
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43862676
25GBX2_23144817_ChIP-Seq_PC3_Human2.43673984
26PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43446010
27TAF15_26573619_Chip-Seq_HEK293_Human2.37699452
28MYB_26560356_Chip-Seq_TH2_Human2.37149743
29MAF_26560356_Chip-Seq_TH1_Human2.32377614
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32084184
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31535196
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30106502
33VDR_21846776_ChIP-Seq_THP-1_Human2.29346358
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22759670
35TP63_17297297_ChIP-ChIP_HaCaT_Human2.21784593
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20612251
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20139082
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14828079
39FOXM1_23109430_ChIP-Seq_U2OS_Human2.10971627
40MYB_26560356_Chip-Seq_TH1_Human2.09099755
41TCF7_22412390_ChIP-Seq_EML_Mouse2.06575203
42SCL_19346495_ChIP-Seq_HPC-7_Human2.03136715
43SALL1_21062744_ChIP-ChIP_HESCs_Human2.03096835
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.99483856
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.98136434
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96940925
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.96483430
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89229119
49UTX_26944678_Chip-Seq_JUKART_Human1.87898401
50VDR_24763502_ChIP-Seq_THP-1_Human1.86449813
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84209392
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83447013
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79577462
54VDR_22108803_ChIP-Seq_LS180_Human1.78163305
55VDR_23849224_ChIP-Seq_CD4+_Human1.78004701
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76413932
57ELK1_19687146_ChIP-ChIP_HELA_Human1.71888600
58ER_23166858_ChIP-Seq_MCF-7_Human1.70837004
59EWS_26573619_Chip-Seq_HEK293_Human1.69331456
60P300_19829295_ChIP-Seq_ESCs_Human1.67216781
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65867457
62GATA1_22025678_ChIP-Seq_K562_Human1.65050222
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.60450735
64SPI1_23547873_ChIP-Seq_NB4_Human1.58293953
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56659326
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56353387
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55539847
68KDM2B_26808549_Chip-Seq_DND41_Human1.53893918
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53585519
70* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52461714
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51385710
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50786530
73* GATA3_27048872_Chip-Seq_THYMUS_Human1.50204260
74EZH2_22144423_ChIP-Seq_EOC_Human1.49340919
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.48185519
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47178620
77CBP_20019798_ChIP-Seq_JUKART_Human1.46934273
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46934273
79IRF1_19129219_ChIP-ChIP_H3396_Human1.46427508
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46398404
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46210792
82PU_27001747_Chip-Seq_BMDM_Mouse1.45644157
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45009072
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44933481
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44785573
86SMAD4_21799915_ChIP-Seq_A2780_Human1.44760840
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.43413558
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42719200
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42441364
90SPI1_23127762_ChIP-Seq_K562_Human1.41465706
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40978586
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40010528
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38316322
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38059600
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37864050
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37695838
97FUS_26573619_Chip-Seq_HEK293_Human1.36544906
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34232508
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34031301
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30773366
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30695415
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30586447
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30299317
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.29888957
105* P53_22387025_ChIP-Seq_ESCs_Mouse1.28965628
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.27900534
107MAF_26560356_Chip-Seq_TH2_Human1.27353191
108* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27191685
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27056573
110STAT3_23295773_ChIP-Seq_U87_Human1.25744118
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25673858
112* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25431265
113CLOCK_20551151_ChIP-Seq_293T_Human1.24959155
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24057658
115* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23603372
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23003855
117* E2F1_18555785_Chip-Seq_ESCs_Mouse1.21782650
118TP53_16413492_ChIP-PET_HCT116_Human1.19700413
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.19029820
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17609453
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16186660
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.15425165
123* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14806230
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14337243
125TP53_22573176_ChIP-Seq_HFKS_Human1.13769268
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12838254
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12830839
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12792078
129* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12656096
130TCF4_23295773_ChIP-Seq_U87_Human1.12546379
131VDR_24787735_ChIP-Seq_THP-1_Human1.12363242
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11916982
133NOTCH1_21737748_ChIP-Seq_TLL_Human1.09897429
134* STAT3_18555785_Chip-Seq_ESCs_Mouse1.09783769
135* P300_18555785_Chip-Seq_ESCs_Mouse1.08823122
136AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08669225
137CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08551154
138* CTCF_18555785_Chip-Seq_ESCs_Mouse1.08410573
139* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06653015
140* OCT4_18555785_Chip-Seq_ESCs_Mouse1.06286660
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.05965060
142* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05769810
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03510213
144* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02524302
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01251794
146NCOR1_26117541_ChIP-Seq_K562_Human1.01119836
147SOX2_19829295_ChIP-Seq_ESCs_Human0.99886951
148NANOG_19829295_ChIP-Seq_ESCs_Human0.99886951
149KDM2B_26808549_Chip-Seq_JURKAT_Human0.99721941
150CIITA_25753668_ChIP-Seq_RAJI_Human0.99593953
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.98932528
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98853322
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97233694
154NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96181543
155GATA3_26560356_Chip-Seq_TH2_Human0.94509025
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93920735
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.93222894
158E2F1_21310950_ChIP-Seq_MCF-7_Human0.90770276
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90287442
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89510666
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89510666
162MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89260046
163TFEB_21752829_ChIP-Seq_HELA_Human0.89114621
164* GATA6_25053715_ChIP-Seq_YYC3_Human0.88818426
165CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87870955
166GATA1_19941826_ChIP-Seq_K562_Human0.87236673
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86594058
168FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85719573
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85570614
170PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84244402
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.83087650
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82513870
173ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80951245
174CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79303607
175LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78991214
176GATA2_21666600_ChIP-Seq_HMVEC_Human0.77859800
177HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76843124
178FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76757566
179UBF1/2_26484160_Chip-Seq_HMECs_Human0.76548998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.57805525
2MP0000685_abnormal_immune_system3.25382408
3MP0002166_altered_tumor_susceptibility3.06478545
4MP0003300_gastrointestinal_ulcer3.05716558
5MP0003436_decreased_susceptibility_to2.74628927
6MP0001790_abnormal_immune_system2.74358860
7MP0005387_immune_system_phenotype2.74358860
8MP0005671_abnormal_response_to2.61791970
9MP0001800_abnormal_humoral_immune2.61192586
10MP0003303_peritoneal_inflammation2.55912349
11MP0002138_abnormal_hepatobiliary_system2.52250077
12MP0003763_abnormal_thymus_physiology2.49175217
13MP0002006_tumorigenesis2.48159150
14MP0005000_abnormal_immune_tolerance2.34303255
15MP0001529_abnormal_vocalization2.31913074
16* MP0002452_abnormal_antigen_presenting2.23901605
17MP0010352_gastrointestinal_tract_polyps2.21347701
18MP0009785_altered_susceptibility_to2.15819357
19* MP0002723_abnormal_immune_serum2.14261248
20MP0002396_abnormal_hematopoietic_system2.11225273
21MP0004947_skin_inflammation2.07360416
22MP0002254_reproductive_system_inflammat2.04744370
23* MP0002420_abnormal_adaptive_immunity2.02911283
24* MP0001819_abnormal_immune_cell2.02461159
25MP0005025_abnormal_response_to1.98573070
26* MP0002398_abnormal_bone_marrow1.98459487
27MP0001984_abnormal_olfaction1.94550211
28MP0002148_abnormal_hypersensitivity_rea1.94239111
29MP0001853_heart_inflammation1.90553325
30MP0004510_myositis1.87735241
31MP0001873_stomach_inflammation1.87294147
32MP0005076_abnormal_cell_differentiation1.87085776
33* MP0002419_abnormal_innate_immunity1.82929218
34MP0003011_delayed_dark_adaptation1.81274912
35MP0010155_abnormal_intestine_physiology1.80592374
36* MP0000716_abnormal_immune_system1.79442162
37MP0004484_altered_response_of1.77909320
38MP0002102_abnormal_ear_morphology1.76846900
39MP0002405_respiratory_system_inflammati1.72742650
40MP0002009_preneoplasia1.69566655
41MP0004808_abnormal_hematopoietic_stem1.68687752
42MP0003195_calcinosis1.66343033
43MP0006082_CNS_inflammation1.65730383
44MP0000427_abnormal_hair_cycle1.65578101
45MP0002877_abnormal_melanocyte_morpholog1.63665469
46MP0005310_abnormal_salivary_gland1.62212265
47* MP0002722_abnormal_immune_system1.60302547
48* MP0000703_abnormal_thymus_morphology1.58948679
49* MP0000689_abnormal_spleen_morphology1.56823304
50* MP0002429_abnormal_blood_cell1.49099674
51MP0005464_abnormal_platelet_physiology1.48904676
52MP0008789_abnormal_olfactory_epithelium1.46857861
53MP0001845_abnormal_inflammatory_respons1.44464390
54MP0006276_abnormal_autonomic_nervous1.43676370
55MP0003724_increased_susceptibility_to1.42296253
56MP0003880_abnormal_central_pattern1.42263203
57MP0001986_abnormal_taste_sensitivity1.42034869
58MP0009333_abnormal_splenocyte_physiolog1.41319213
59MP0003453_abnormal_keratinocyte_physiol1.34550400
60MP0009278_abnormal_bone_marrow1.33798091
61MP0003866_abnormal_defecation1.33079754
62MP0008875_abnormal_xenobiotic_pharmacok1.32656051
63MP0003705_abnormal_hypodermis_morpholog1.31631519
64MP0005397_hematopoietic_system_phenotyp1.28576297
65MP0001545_abnormal_hematopoietic_system1.28576297
66MP0008057_abnormal_DNA_replication1.27825492
67MP0008877_abnormal_DNA_methylation1.25832530
68MP0001533_abnormal_skeleton_physiology1.25506894
69MP0010307_abnormal_tumor_latency1.24619428
70MP0000465_gastrointestinal_hemorrhage1.22970211
71MP0002933_joint_inflammation1.21131938
72MP0005394_taste/olfaction_phenotype1.19673791
73MP0005499_abnormal_olfactory_system1.19673791
74MP0005253_abnormal_eye_physiology1.18871727
75MP0004782_abnormal_surfactant_physiolog1.18046604
76MP0003448_altered_tumor_morphology1.15514895
77MP0010234_abnormal_vibrissa_follicle1.14099754
78MP0004142_abnormal_muscle_tone1.12754256
79MP0001348_abnormal_lacrimal_gland1.10893538
80MP0000569_abnormal_digit_pigmentation1.09868712
81MP0003566_abnormal_cell_adhesion1.06396471
82MP0008469_abnormal_protein_level1.05256584
83MP0008775_abnormal_heart_ventricle1.05176049
84MP0000490_abnormal_crypts_of1.04308854
85MP0000858_altered_metastatic_potential1.00828148
86MP0009840_abnormal_foam_cell1.00742811
87MP0003221_abnormal_cardiomyocyte_apopto0.99419513
88MP0002332_abnormal_exercise_endurance0.97523059
89MP0006054_spinal_hemorrhage0.95263061
90MP0000383_abnormal_hair_follicle0.92189715
91MP0001764_abnormal_homeostasis0.91926016
92MP0004185_abnormal_adipocyte_glucose0.91610414
93MP0003091_abnormal_cell_migration0.91104944
94MP0009764_decreased_sensitivity_to0.90828124
95MP0000609_abnormal_liver_physiology0.90813613
96MP0010678_abnormal_skin_adnexa0.88170480
97MP0008873_increased_physiological_sensi0.87999125
98MP0009765_abnormal_xenobiotic_induced0.87538650
99MP0002019_abnormal_tumor_incidence0.85605311
100MP0008260_abnormal_autophagy0.84876487
101MP0005390_skeleton_phenotype0.84610401
102MP0008058_abnormal_DNA_repair0.83845033
103MP0001501_abnormal_sleep_pattern0.83398518
104MP0003191_abnormal_cellular_cholesterol0.83064054
105MP0000733_abnormal_muscle_development0.82543404
106MP0001881_abnormal_mammary_gland0.80553213
107MP0004215_abnormal_myocardial_fiber0.79771213
108MP0005248_abnormal_Harderian_gland0.79749125
109MP0001216_abnormal_epidermal_layer0.79485156
110MP0004885_abnormal_endolymph0.79406103
111MP0003172_abnormal_lysosome_physiology0.79297206
112MP0001851_eye_inflammation0.78847621
113* MP0002998_abnormal_bone_remodeling0.78144366
114MP0004924_abnormal_behavior0.78119242
115MP0005386_behavior/neurological_phenoty0.78119242
116MP0003183_abnormal_peptide_metabolism0.77705341
117MP0001502_abnormal_circadian_rhythm0.77549645
118MP0005058_abnormal_lysosome_morphology0.76959445
119* MP0000647_abnormal_sebaceous_gland0.76490457
120MP0006035_abnormal_mitochondrial_morpho0.75034845
121* MP0002095_abnormal_skin_pigmentation0.74666494
122MP0005646_abnormal_pituitary_gland0.73952089
123MP0002928_abnormal_bile_duct0.72806656
124MP0009763_increased_sensitivity_to0.71079195
125MP0000371_diluted_coat_color0.69791310
126MP0005023_abnormal_wound_healing0.69734431
127MP0001849_ear_inflammation0.69133717
128MP0002098_abnormal_vibrissa_morphology0.66400601
129MP0001915_intracranial_hemorrhage0.65674403
130MP0000627_abnormal_mammary_gland0.65473677
131MP0002736_abnormal_nociception_after0.65186088
132MP0000015_abnormal_ear_pigmentation0.65052988
133* MP0000598_abnormal_liver_morphology0.64907251
134MP0003252_abnormal_bile_duct0.64526360
135MP0001191_abnormal_skin_condition0.64056413
136MP0008961_abnormal_basal_metabolism0.63135162
137MP0001879_abnormal_lymphatic_vessel0.62726344
138MP0003077_abnormal_cell_cycle0.62287034
139MP0003828_pulmonary_edema0.61342090
140MP0001346_abnormal_lacrimal_gland0.61280725
141MP0002136_abnormal_kidney_physiology0.60966403
142MP0001243_abnormal_dermal_layer0.60800802
143MP0002277_abnormal_respiratory_mucosa0.60402047
144MP0004147_increased_porphyrin_level0.60202234
145MP0010094_abnormal_chromosome_stability0.59154433
146MP0005084_abnormal_gallbladder_morpholo0.59056721
147MP0001919_abnormal_reproductive_system0.58910514
148MP0002751_abnormal_autonomic_nervous0.56209138
149MP0008007_abnormal_cellular_replicative0.53460645

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)4.67022973
2Recurrent fungal infections (HP:0002841)4.42492377
3T lymphocytopenia (HP:0005403)4.04710933
4Abnormality of T cell number (HP:0011839)4.02978285
5Eczematoid dermatitis (HP:0000976)4.01844315
6Abnormality of the fingertips (HP:0001211)3.55648704
7Chronic otitis media (HP:0000389)3.51406602
8Panhypogammaglobulinemia (HP:0003139)3.47735447
9Methylmalonic acidemia (HP:0002912)3.37788065
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.33469833
11Chronic mucocutaneous candidiasis (HP:0002728)3.27570558
12Recurrent cutaneous fungal infections (HP:0011370)3.27570558
13Medial flaring of the eyebrow (HP:0010747)3.14394105
14Recurrent bacterial skin infections (HP:0005406)3.11942365
15Autoimmune thrombocytopenia (HP:0001973)3.11203811
16Myositis (HP:0100614)3.08278141
17Abnormality of T cells (HP:0002843)3.05797085
18Cellulitis (HP:0100658)3.05147414
19Elevated erythrocyte sedimentation rate (HP:0003565)2.95117955
20Increased IgE level (HP:0003212)2.95027872
21Thyroiditis (HP:0100646)2.94651474
22Agammaglobulinemia (HP:0004432)2.94594412
23Abnormality of B cell number (HP:0010975)2.94578106
24B lymphocytopenia (HP:0010976)2.94578106
25Eosinophilia (HP:0001880)2.91006945
26Lipid accumulation in hepatocytes (HP:0006561)2.90555922
27Recurrent skin infections (HP:0001581)2.87495730
28Recurrent abscess formation (HP:0002722)2.86578872
29Nephrogenic diabetes insipidus (HP:0009806)2.86507759
30Progressive inability to walk (HP:0002505)2.81390497
31Congenital primary aphakia (HP:0007707)2.80911087
32Severe combined immunodeficiency (HP:0004430)2.75779846
33Gait imbalance (HP:0002141)2.74995124
34Hematochezia (HP:0002573)2.74750626
35Meningitis (HP:0001287)2.74686461
36Chronic hepatic failure (HP:0100626)2.73938437
37Arterial thrombosis (HP:0004420)2.72575024
38Retrobulbar optic neuritis (HP:0100654)2.71859271
39Optic neuritis (HP:0100653)2.71859271
40Loss of speech (HP:0002371)2.71390970
41Vasculitis (HP:0002633)2.70877876
42Thrombocytosis (HP:0001894)2.69978334
43Verrucae (HP:0200043)2.69527811
44Papilloma (HP:0012740)2.69527811
45Mediastinal lymphadenopathy (HP:0100721)2.65195351
46Chronic diarrhea (HP:0002028)2.64746069
47Orchitis (HP:0100796)2.64577425
48Spontaneous hematomas (HP:0007420)2.63964284
49Inflammation of the large intestine (HP:0002037)2.63121769
50Pancreatic cysts (HP:0001737)2.62860411
51Lissencephaly (HP:0001339)2.61606613
52Recurrent bronchitis (HP:0002837)2.59599936
53Gastrointestinal inflammation (HP:0004386)2.58441125
54Combined immunodeficiency (HP:0005387)2.58397569
55Gingival bleeding (HP:0000225)2.56493538
56Rimmed vacuoles (HP:0003805)2.54380523
57Leukocytosis (HP:0001974)2.52277439
58Myocardial infarction (HP:0001658)2.50688893
59Increased hepatocellular lipid droplets (HP:0006565)2.49676903
60Postaxial foot polydactyly (HP:0001830)2.46921118
61Granulocytopenia (HP:0001913)2.45635167
62Colitis (HP:0002583)2.44151593
63Osteomyelitis (HP:0002754)2.42621478
64Pulmonary infiltrates (HP:0002113)2.41464849
65Methylmalonic aciduria (HP:0012120)2.40706484
66Abnormality of T cell physiology (HP:0011840)2.40486428
67Amyotrophic lateral sclerosis (HP:0007354)2.39708451
68Fatigue (HP:0012378)2.39460770
69IgM deficiency (HP:0002850)2.37102708
70Stomatitis (HP:0010280)2.35756821
71Abnormality of eosinophils (HP:0001879)2.35117369
72Median cleft lip (HP:0000161)2.33864703
73Interstitial pulmonary disease (HP:0006530)2.31824946
74IgA deficiency (HP:0002720)2.31812813
75Osteolytic defects of the hand bones (HP:0009699)2.30649507
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.30649507
77Nasal polyposis (HP:0100582)2.29871200
78Hypoplasia of the thymus (HP:0000778)2.29320170
79Retinal dysplasia (HP:0007973)2.29086259
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25195172
81Short 4th metacarpal (HP:0010044)2.25195172
82Gastrointestinal infarctions (HP:0005244)2.20810328
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.20711948
84Type II lissencephaly (HP:0007260)2.20476667
85Lymphopenia (HP:0001888)2.20440164
86Abnormality of the renal cortex (HP:0011035)2.18775186
87Absent speech (HP:0001344)2.18196441
88Abnormality of macrophages (HP:0004311)2.16167819
89Recurrent gram-negative bacterial infections (HP:0005420)2.15031408
90Asymmetric septal hypertrophy (HP:0001670)2.14547208
91Attenuation of retinal blood vessels (HP:0007843)2.13985880
92Widely spaced teeth (HP:0000687)2.13706078
93IgG deficiency (HP:0004315)2.13569186
94Hemoptysis (HP:0002105)2.12983169
95Acute myeloid leukemia (HP:0004808)2.10541911
96Long clavicles (HP:0000890)2.09720698
97True hermaphroditism (HP:0010459)2.09520026
98Increased density of long bones (HP:0006392)2.09504415
99Cutis marmorata (HP:0000965)2.09167947
100Hyperventilation (HP:0002883)2.08645645
101Esophageal varix (HP:0002040)2.08267327
102Chest pain (HP:0100749)2.06104934
103Persistence of primary teeth (HP:0006335)2.05907100
104Pancreatic fibrosis (HP:0100732)2.04314013
105* Periodontitis (HP:0000704)2.03743419
106Facial diplegia (HP:0001349)2.03413729
107Keratoconjunctivitis (HP:0001096)2.00862450
108Abolished electroretinogram (ERG) (HP:0000550)2.00768752
109Epistaxis (HP:0000421)1.99753403
1103-Methylglutaconic aciduria (HP:0003535)1.99310826
111Abnormality of the nasal mucosa (HP:0000433)1.99041310
112Drooling (HP:0002307)1.97181511
113Skin ulcer (HP:0200042)1.97177379
114Gastrointestinal stroma tumor (HP:0100723)1.96538852
115Stomach cancer (HP:0012126)1.96346207
116Cone-rod dystrophy (HP:0000548)1.94816369
117Hypochromic microcytic anemia (HP:0004840)1.94405733
118Neutropenia (HP:0001875)1.93987630
119Type 2 muscle fiber atrophy (HP:0003554)1.93640247
120Vaginal atresia (HP:0000148)1.92764536
121Abnormality of the renal medulla (HP:0100957)1.92495449
122Keratoconjunctivitis sicca (HP:0001097)1.91916924
123Genital tract atresia (HP:0001827)1.91278452
124Hypothermia (HP:0002045)1.91096139
125Excessive salivation (HP:0003781)1.90814862
126Volvulus (HP:0002580)1.90630793
127Hypergammaglobulinemia (HP:0010702)1.89565579
128Papillary thyroid carcinoma (HP:0002895)1.89295601
129Joint swelling (HP:0001386)1.88487576
130Abnormal platelet volume (HP:0011876)1.87177361
131Pulmonary embolism (HP:0002204)1.86695385
132Renal Fanconi syndrome (HP:0001994)1.86189980
133Encephalitis (HP:0002383)1.86157904
134Hyperglycinemia (HP:0002154)1.86007512
135Abnormality of midbrain morphology (HP:0002418)1.86005880
136Molar tooth sign on MRI (HP:0002419)1.86005880
137Amaurosis fugax (HP:0100576)1.85077476
138Specific learning disability (HP:0001328)1.84714457
139Pustule (HP:0200039)1.83692922
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82885716
141Abnormality of polysaccharide metabolism (HP:0011012)1.82885716
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82885716
143Abnormality of skull ossification (HP:0002703)1.82878046
144Generalized aminoaciduria (HP:0002909)1.82380097
145Disproportionate short-trunk short stature (HP:0003521)1.81869636
146Postaxial hand polydactyly (HP:0001162)1.81730929
147Macroorchidism (HP:0000053)1.81237297
148Emphysema (HP:0002097)1.81166713
149Abnormal biliary tract physiology (HP:0012439)1.81057956
150Bile duct proliferation (HP:0001408)1.81057956
151Keratitis (HP:0000491)1.80501403
152Portal hypertension (HP:0001409)1.79670792
153Pancreatic islet-cell hyperplasia (HP:0004510)1.79490362
154Urinary glycosaminoglycan excretion (HP:0003541)1.79479781
155Mucopolysacchariduria (HP:0008155)1.79479781
156Abnormality of the musculature of the pelvis (HP:0001469)1.79145364
157Abnormality of the hip-girdle musculature (HP:0001445)1.79145364
158Exertional dyspnea (HP:0002875)1.78719256
159Cutaneous melanoma (HP:0012056)1.78641355
160Hypokalemic alkalosis (HP:0001949)1.78302760
161Inability to walk (HP:0002540)1.77353609
162Toxemia of pregnancy (HP:0100603)1.77183539
163Autoimmune hemolytic anemia (HP:0001890)1.77160096
164Abnormality of the vitamin B12 metabolism (HP:0004341)1.76805015
165Increased cerebral lipofuscin (HP:0011813)1.76098925
166Lymphoma (HP:0002665)1.76081362
167Sepsis (HP:0100806)1.73769961
168Chronic obstructive pulmonary disease (HP:0006510)1.73234371
169Obstructive lung disease (HP:0006536)1.73234371
170Gingivitis (HP:0000230)1.71025140
171Thrombophlebitis (HP:0004418)1.70687147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.64874530
2TESK23.16417906
3MAP3K143.09894464
4JAK32.93668373
5BCKDK2.75143978
6TXK2.65837311
7MAP3K102.63277222
8TYK22.61388027
9NUAK12.55538427
10FGFR42.50528868
11BCR2.39823845
12ACVR1B2.31856085
13MAP3K42.27119992
14CDK122.24544302
15EEF2K2.15171578
16STK102.12272823
17TBK12.09897813
18FGFR32.06775322
19NEK12.05027963
20TRIB32.04195776
21JAK11.89253823
22IKBKB1.84817166
23CHUK1.84408105
24ERN11.83744353
25ZAP701.82895927
26EPHB11.79700954
27IKBKE1.78876571
28ITK1.76827916
29PKN21.74449737
30WNK31.70816278
31PTK61.67359147
32GRK71.60049935
33BTK1.54076747
34ERBB31.52642898
35TLK11.44083169
36CDC42BPA1.41390865
37LRRK21.40253664
38RPS6KA41.39282286
39FLT31.39029590
40EPHA31.38275570
41IRAK41.36445492
42MAP2K71.36049101
43SIK31.33382052
44MAP3K131.32818734
45SIK11.31447780
46KIT1.29581478
47NLK1.25483977
48GRK61.25370557
49ADRBK21.24173140
50MAP4K21.23326738
51NEK91.23009562
52SGK21.22986924
53SYK1.22834261
54CDK61.21623853
55TAOK31.21613547
56TRIM281.20725362
57CSF1R1.18604549
58CDK81.18287734
59JAK21.15935822
60HCK1.15830730
61TIE11.14047594
62MARK11.13940612
63FGFR21.12878098
64TGFBR21.12147896
65EIF2AK31.11536519
66LCK1.10493108
67CSK1.10272807
68PIM11.08481489
69CAMK1D1.06255338
70TNK21.03623311
71BMPR1B1.02917589
72TEC1.02301361
73AKT31.00073439
74OBSCN0.96293651
75MAPK130.94433744
76CDK40.91411735
77STK40.90720726
78BRD40.87744598
79FER0.87171952
80HIPK20.84622243
81CDK30.84420421
82SRPK10.83622672
83PAK30.82640188
84BLK0.82636941
85ZAK0.81762553
86MAP2K30.81166782
87STK30.80875227
88MAP3K70.78282674
89CSNK1A1L0.78139503
90CDK90.77451416
91PASK0.75576963
92IRAK10.74237836
93IRAK30.72417638
94PIM20.72096546
95PDGFRB0.70072538
96LYN0.69387153
97DYRK30.68753347
98TGFBR10.67746565
99MAP3K80.66472982
100PRKCQ0.65714358
101TTN0.65396670
102MATK0.65282435
103MAPK110.64937350
104CAMK1G0.63891764
105MTOR0.63784886
106ADRBK10.61913417
107TNIK0.61892489
108RET0.61883317
109DYRK1B0.61762902
110NEK20.61711703
111RAF10.61180828
112SGK2230.60800355
113SGK4940.60800355
114ALK0.59741288
115CLK10.57826116
116MELK0.57145216
117MKNK10.56278111
118PRKCH0.56224154
119DMPK0.55180601
120BMX0.55135345
121INSRR0.54456407
122CSNK1G10.54306572
123MAP3K50.54110766
124FRK0.52560588
125MAPKAPK20.52340024
126PLK20.51757807
127CSNK1G30.50217819
128PRKAA20.49819838
129MKNK20.48935451
130MARK30.48723342
131EGFR0.48657907
132TRPM70.47856049
133SGK30.47065641
134RPS6KA50.46932057
135STK240.45945848
136RIPK10.44676320
137FGFR10.44370337
138RPS6KB20.43109809
139CDK190.42707596
140MAP3K30.42059250
141PAK60.41731510
142LATS10.41204825
143KDR0.39296143
144ABL10.39197079
145FGR0.38820710
146FES0.38568186
147ATR0.37201621
148MAPK70.36801301
149MAP2K20.36157219
150MST40.34655132
151SCYL20.34120752
152RPS6KA10.31330589
153IGF1R0.30120519

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.94175524
2* NF-kappa B signaling pathway_Homo sapiens_hsa040642.85903185
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46708388
4Allograft rejection_Homo sapiens_hsa053302.34462214
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.29615113
6* Leishmaniasis_Homo sapiens_hsa051402.29083983
7* Measles_Homo sapiens_hsa051622.27036035
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20048150
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18393531
10B cell receptor signaling pathway_Homo sapiens_hsa046622.16655386
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12796957
12* Osteoclast differentiation_Homo sapiens_hsa043802.08092070
13Antigen processing and presentation_Homo sapiens_hsa046121.98903137
14Rheumatoid arthritis_Homo sapiens_hsa053231.97862143
15Circadian rhythm_Homo sapiens_hsa047101.96895027
16T cell receptor signaling pathway_Homo sapiens_hsa046601.94938449
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.92764585
18* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81143124
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.78435019
20* Toxoplasmosis_Homo sapiens_hsa051451.76111921
21Chronic myeloid leukemia_Homo sapiens_hsa052201.70268827
22Graft-versus-host disease_Homo sapiens_hsa053321.66285302
23TNF signaling pathway_Homo sapiens_hsa046681.62796429
24* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62072525
25* Herpes simplex infection_Homo sapiens_hsa051681.55278806
26Basal transcription factors_Homo sapiens_hsa030221.54384335
27Acute myeloid leukemia_Homo sapiens_hsa052211.53534468
28Staphylococcus aureus infection_Homo sapiens_hsa051501.52943675
29Legionellosis_Homo sapiens_hsa051341.51343221
30* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46875842
31Influenza A_Homo sapiens_hsa051641.46438835
32Protein export_Homo sapiens_hsa030601.44485785
33Hematopoietic cell lineage_Homo sapiens_hsa046401.42127275
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42073879
35Hepatitis B_Homo sapiens_hsa051611.40246397
36Autoimmune thyroid disease_Homo sapiens_hsa053201.39601753
37Apoptosis_Homo sapiens_hsa042101.39385342
38Viral myocarditis_Homo sapiens_hsa054161.39200334
39RNA degradation_Homo sapiens_hsa030181.28849741
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28111611
41* Small cell lung cancer_Homo sapiens_hsa052221.27271301
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27166071
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26816683
44Type I diabetes mellitus_Homo sapiens_hsa049401.26694542
45Regulation of autophagy_Homo sapiens_hsa041401.25541811
46Viral carcinogenesis_Homo sapiens_hsa052031.23368191
47Chemokine signaling pathway_Homo sapiens_hsa040621.23356320
48Fanconi anemia pathway_Homo sapiens_hsa034601.23282100
49Asthma_Homo sapiens_hsa053101.18103113
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17378744
51Pancreatic cancer_Homo sapiens_hsa052121.17366769
52Shigellosis_Homo sapiens_hsa051311.16627328
53Steroid biosynthesis_Homo sapiens_hsa001001.16297326
54Nitrogen metabolism_Homo sapiens_hsa009101.16097124
55Prolactin signaling pathway_Homo sapiens_hsa049171.16020092
56Propanoate metabolism_Homo sapiens_hsa006401.14184705
57Collecting duct acid secretion_Homo sapiens_hsa049661.13104824
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11953746
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11517684
60* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10241165
61Lysine degradation_Homo sapiens_hsa003101.10106294
62* Tuberculosis_Homo sapiens_hsa051521.07790140
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.07759348
64* Pertussis_Homo sapiens_hsa051331.07679887
65Malaria_Homo sapiens_hsa051441.06408553
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05010766
67HTLV-I infection_Homo sapiens_hsa051661.03840736
68Phototransduction_Homo sapiens_hsa047441.03687755
69MicroRNAs in cancer_Homo sapiens_hsa052061.02397697
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00795854
71Insulin resistance_Homo sapiens_hsa049310.98981950
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97040491
73Butanoate metabolism_Homo sapiens_hsa006500.96260216
74Caffeine metabolism_Homo sapiens_hsa002320.95407270
75One carbon pool by folate_Homo sapiens_hsa006700.92465197
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92069519
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91636701
78* Hepatitis C_Homo sapiens_hsa051600.88498391
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86093579
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.85995775
81Non-small cell lung cancer_Homo sapiens_hsa052230.84090704
82* Epstein-Barr virus infection_Homo sapiens_hsa051690.82140960
83Non-homologous end-joining_Homo sapiens_hsa034500.81774752
84Platelet activation_Homo sapiens_hsa046110.81408085
85Prostate cancer_Homo sapiens_hsa052150.80302826
86Tryptophan metabolism_Homo sapiens_hsa003800.79229186
87* Neurotrophin signaling pathway_Homo sapiens_hsa047220.74736929
88Notch signaling pathway_Homo sapiens_hsa043300.73303364
89Peroxisome_Homo sapiens_hsa041460.73245105
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71749742
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70018229
92FoxO signaling pathway_Homo sapiens_hsa040680.68153362
93Systemic lupus erythematosus_Homo sapiens_hsa053220.67365165
94p53 signaling pathway_Homo sapiens_hsa041150.67354033
95* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66993348
96Homologous recombination_Homo sapiens_hsa034400.66835692
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65605379
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.63106613
99Proteoglycans in cancer_Homo sapiens_hsa052050.62319119
100mTOR signaling pathway_Homo sapiens_hsa041500.62118549
101Proteasome_Homo sapiens_hsa030500.60457200
102Salmonella infection_Homo sapiens_hsa051320.60116310
103Colorectal cancer_Homo sapiens_hsa052100.56745354
104Type II diabetes mellitus_Homo sapiens_hsa049300.55249622
105Adherens junction_Homo sapiens_hsa045200.54307982
106mRNA surveillance pathway_Homo sapiens_hsa030150.52904687
107African trypanosomiasis_Homo sapiens_hsa051430.52250480
108HIF-1 signaling pathway_Homo sapiens_hsa040660.51976877
109Thyroid cancer_Homo sapiens_hsa052160.51904692
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50647742
111Selenocompound metabolism_Homo sapiens_hsa004500.50526292
112VEGF signaling pathway_Homo sapiens_hsa043700.49462503
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48667454
114ABC transporters_Homo sapiens_hsa020100.48380726
115Renal cell carcinoma_Homo sapiens_hsa052110.47944555
116Amoebiasis_Homo sapiens_hsa051460.46713401
117Lysosome_Homo sapiens_hsa041420.46457887
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45433074
119Taste transduction_Homo sapiens_hsa047420.43688479
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.42330207
121Endometrial cancer_Homo sapiens_hsa052130.41894217
122Dorso-ventral axis formation_Homo sapiens_hsa043200.41291949
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40891828
124Phagosome_Homo sapiens_hsa041450.40543001
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38823634
126* Pathways in cancer_Homo sapiens_hsa052000.38511850
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.37497631
128Complement and coagulation cascades_Homo sapiens_hsa046100.35186585
129Phenylalanine metabolism_Homo sapiens_hsa003600.35067960
130Fatty acid elongation_Homo sapiens_hsa000620.34587137
131Other glycan degradation_Homo sapiens_hsa005110.31600693
132Linoleic acid metabolism_Homo sapiens_hsa005910.31331159
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30631163
134Sulfur metabolism_Homo sapiens_hsa009200.30603319
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30258505
136Cell cycle_Homo sapiens_hsa041100.30210100
137Ether lipid metabolism_Homo sapiens_hsa005650.29809574
138Focal adhesion_Homo sapiens_hsa045100.28533947
139Olfactory transduction_Homo sapiens_hsa047400.28476462
140Glioma_Homo sapiens_hsa052140.27993916
141Nucleotide excision repair_Homo sapiens_hsa034200.24645268
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24634400
143Mismatch repair_Homo sapiens_hsa034300.24400434
144RNA polymerase_Homo sapiens_hsa030200.24236964
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22172788
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22006838
147Purine metabolism_Homo sapiens_hsa002300.21411205

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