TRAF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.12242963
2COPI coating of Golgi vesicle (GO:0048205)5.12242963
3proline biosynthetic process (GO:0006561)4.43761038
4DNA unwinding involved in DNA replication (GO:0006268)4.35086047
5protein retention in ER lumen (GO:0006621)4.06947479
6DNA strand elongation involved in DNA replication (GO:0006271)3.97194704
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.96646707
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88413172
9adherens junction assembly (GO:0034333)3.87274945
10protein localization to kinetochore (GO:0034501)3.86867525
11viral transcription (GO:0019083)3.83866466
12regulation of early endosome to late endosome transport (GO:2000641)3.80174221
13maturation of SSU-rRNA (GO:0030490)3.79772013
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.75646991
15DNA replication initiation (GO:0006270)3.75525906
16focal adhesion assembly (GO:0048041)3.75340980
17cell-substrate adherens junction assembly (GO:0007045)3.75340980
18formation of translation preinitiation complex (GO:0001731)3.75321332
19DNA strand elongation (GO:0022616)3.74674290
20regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73378235
21ribosomal small subunit assembly (GO:0000028)3.72220181
22translational termination (GO:0006415)3.71841732
23protein localization to endosome (GO:0036010)3.70040304
24mitotic nuclear envelope disassembly (GO:0007077)3.68883480
25activation of Rac GTPase activity (GO:0032863)3.63457179
26pentose-phosphate shunt (GO:0006098)3.61893318
27telomere maintenance via semi-conservative replication (GO:0032201)3.60256460
28negative regulation of cell size (GO:0045792)3.58422869
29cell-substrate junction assembly (GO:0007044)3.52099037
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50454190
31desmosome organization (GO:0002934)3.48296016
32apoptotic process involved in morphogenesis (GO:0060561)3.44250894
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42236084
34membrane disassembly (GO:0030397)3.41728468
35nuclear envelope disassembly (GO:0051081)3.41728468
36cellular protein complex localization (GO:0034629)3.40596091
37basement membrane organization (GO:0071711)3.40117991
38translational elongation (GO:0006414)3.38939806
39epithelial cell-cell adhesion (GO:0090136)3.38318299
40translational initiation (GO:0006413)3.36149837
41hemidesmosome assembly (GO:0031581)3.35087754
42glucose 6-phosphate metabolic process (GO:0051156)3.34149651
43maternal placenta development (GO:0001893)3.33712957
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32149700
45protein localization to chromosome, centromeric region (GO:0071459)3.31450792
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.27732267
47DNA replication-dependent nucleosome organization (GO:0034723)3.26278899
48DNA replication-dependent nucleosome assembly (GO:0006335)3.26278899
49protein complex localization (GO:0031503)3.25579919
50negative regulation of RNA splicing (GO:0033119)3.24998668
51glucose catabolic process (GO:0006007)3.21157405
52mitotic chromosome condensation (GO:0007076)3.21106985
53positive regulation of Cdc42 GTPase activity (GO:0043089)3.20657692
54semaphorin-plexin signaling pathway (GO:0071526)3.20420278
553-UTR-mediated mRNA stabilization (GO:0070935)3.18636007
56telomere maintenance via recombination (GO:0000722)3.16803927
57regulation of glucose import in response to insulin stimulus (GO:2001273)3.16369238
58NADPH regeneration (GO:0006740)3.14970465
59mitotic metaphase plate congression (GO:0007080)3.14207101
60DNA replication checkpoint (GO:0000076)3.13109283
61mitotic recombination (GO:0006312)3.08862984
62regulation of spindle organization (GO:0090224)3.06904912
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06340206
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05526693
65IMP biosynthetic process (GO:0006188)3.02779400
66telomere maintenance via telomere lengthening (GO:0010833)3.02625722
67pinocytosis (GO:0006907)2.99104318
68proline metabolic process (GO:0006560)2.98867082
69nuclear pore organization (GO:0006999)2.98756322
70RNA stabilization (GO:0043489)2.98431682
71mRNA stabilization (GO:0048255)2.98431682
72DNA duplex unwinding (GO:0032508)2.97958971
73mitotic sister chromatid segregation (GO:0000070)2.97841209
74negative regulation of erythrocyte differentiation (GO:0045647)2.97450006
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97339750
76urea cycle (GO:0000050)2.96729956
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96031588
78viral life cycle (GO:0019058)2.95505034
79barbed-end actin filament capping (GO:0051016)2.95368941
80DNA geometric change (GO:0032392)2.95164926
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95094516
82regulation of mitotic spindle organization (GO:0060236)2.92991943
83ribosomal small subunit biogenesis (GO:0042274)2.91376712
84cellular protein complex disassembly (GO:0043624)2.90153156
85negative regulation of fatty acid transport (GO:2000192)2.89382330
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.88995455
87positive regulation of nuclease activity (GO:0032075)2.88126543
88protein targeting to ER (GO:0045047)2.88085555
89ribosomal large subunit biogenesis (GO:0042273)2.87974536
90folic acid-containing compound biosynthetic process (GO:0009396)2.87756701
91cotranslational protein targeting to membrane (GO:0006613)2.86488878
92kinetochore organization (GO:0051383)2.86458751
93sister chromatid segregation (GO:0000819)2.86337715
94embryonic process involved in female pregnancy (GO:0060136)2.85553371
95branching involved in mammary gland duct morphogenesis (GO:0060444)2.83796224
96epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82892422
97nuclear pore complex assembly (GO:0051292)2.82776012
98nuclear envelope organization (GO:0006998)2.82370715
99dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81847143
100metaphase plate congression (GO:0051310)2.80304590
101nucleobase biosynthetic process (GO:0046112)2.80044555
102negative regulation of mRNA processing (GO:0050686)2.79028683
103protein complex disassembly (GO:0043241)2.78300648
104regulation of posttranscriptional gene silencing (GO:0060147)2.76435246
105regulation of gene silencing by miRNA (GO:0060964)2.76435246
106regulation of gene silencing by RNA (GO:0060966)2.76435246
107regulation of cholesterol biosynthetic process (GO:0045540)2.75130454
108negative regulation of histone methylation (GO:0031061)2.73842954
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73814932
110mannose metabolic process (GO:0006013)2.73146205
111regulation of translational fidelity (GO:0006450)2.72691098
112heterochromatin organization (GO:0070828)2.71998566
113establishment of chromosome localization (GO:0051303)2.69812738
114skin morphogenesis (GO:0043589)2.69789658
115positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69562075
116establishment of apical/basal cell polarity (GO:0035089)2.68512663
117regulation of NFAT protein import into nucleus (GO:0051532)2.67816875
118stress fiber assembly (GO:0043149)2.67136695
119regulation of cholesterol homeostasis (GO:2000188)2.66607745
120cellular response to epidermal growth factor stimulus (GO:0071364)2.66258439
121DNA replication-independent nucleosome assembly (GO:0006336)2.64613061
122DNA replication-independent nucleosome organization (GO:0034724)2.64613061
123negative regulation of chromosome segregation (GO:0051985)2.64202129
124endoplasmic reticulum unfolded protein response (GO:0030968)2.63627284
125mRNA splicing, via spliceosome (GO:0000398)2.62917461
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62917461
127nuclear-transcribed mRNA catabolic process (GO:0000956)2.62761034
128urea metabolic process (GO:0019627)2.62336725
129protein localization to endoplasmic reticulum (GO:0070972)2.61480958
130mitotic spindle assembly checkpoint (GO:0007094)2.60445206
131intracellular estrogen receptor signaling pathway (GO:0030520)2.60172022
132RNA splicing, via transesterification reactions (GO:0000375)2.59468853
133ribonucleoprotein complex biogenesis (GO:0022613)2.59362738
134positive regulation of chromosome segregation (GO:0051984)2.59326414
135spindle assembly checkpoint (GO:0071173)2.58696893
136kinetochore assembly (GO:0051382)2.58492779
137modulation by virus of host morphology or physiology (GO:0019048)2.58089766
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57811315
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57811315
140negative regulation of sister chromatid segregation (GO:0033046)2.57811315
141negative regulation of mitotic sister chromatid separation (GO:2000816)2.57811315
142ER-nucleus signaling pathway (GO:0006984)2.57576954
143regulation of nuclease activity (GO:0032069)2.57234202
144modulation by symbiont of host cellular process (GO:0044068)2.57055665
145IMP metabolic process (GO:0046040)2.56883484
146macromolecular complex disassembly (GO:0032984)2.56577679
147chromatin assembly or disassembly (GO:0006333)2.55750549
148spliceosomal snRNP assembly (GO:0000387)2.54636996
149glutamine family amino acid biosynthetic process (GO:0009084)2.54612939
150regulation of chromosome segregation (GO:0051983)2.54537208
151positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54070056
152CENP-A containing nucleosome assembly (GO:0034080)2.53308479
153regulation of protein heterodimerization activity (GO:0043497)2.52226739
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51812090
155histone H2A acetylation (GO:0043968)2.51608412
156mRNA catabolic process (GO:0006402)2.50819375
157regulation of histone H3-K9 methylation (GO:0051570)2.50239985
158protein-DNA complex disassembly (GO:0032986)2.50079083
159nucleosome disassembly (GO:0006337)2.50079083
160RNA catabolic process (GO:0006401)2.50043540
161chromatin remodeling at centromere (GO:0031055)2.50038129
162attachment of spindle microtubules to kinetochore (GO:0008608)2.49953908
163response to laminar fluid shear stress (GO:0034616)2.49040439
164DNA conformation change (GO:0071103)2.48620741
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.48148160
166DNA topological change (GO:0006265)2.46877136
167protein localization to chromosome (GO:0034502)2.46604411
168peptidyl-arginine omega-N-methylation (GO:0035247)2.46600192
169spindle checkpoint (GO:0031577)2.46540556
170regulation of extracellular matrix disassembly (GO:0010715)2.46087783
171diaphragm development (GO:0060539)2.45927401
172mitotic spindle checkpoint (GO:0071174)2.45373866
173modulation by virus of host process (GO:0019054)2.43413303
174adenine nucleotide transport (GO:0051503)2.43235081
175protein maturation by protein folding (GO:0022417)2.41485096
176embryonic eye morphogenesis (GO:0048048)2.41331231
177positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.41018774
178positive regulation of keratinocyte differentiation (GO:0045618)2.40411975
179vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39597660
180cellular response to unfolded protein (GO:0034620)2.39175793
181positive regulation of DNA-dependent DNA replication (GO:2000105)2.36341131
182Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.35834608
183convergent extension (GO:0060026)2.33314460
184protein export from nucleus (GO:0006611)2.32383074
185nuclear envelope reassembly (GO:0031468)2.31679115
186mitotic nuclear envelope reassembly (GO:0007084)2.31679115
187atrioventricular valve morphogenesis (GO:0003181)2.31561656
188regulation of histone H3-K27 methylation (GO:0061085)2.31128918
189vesicle coating (GO:0006901)2.30554853
190peptidyl-arginine methylation (GO:0018216)2.28887469
191peptidyl-arginine N-methylation (GO:0035246)2.28887469
192embryo implantation (GO:0007566)2.28824705
193negative regulation of viral release from host cell (GO:1902187)2.28245159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72434303
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53463530
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.62988962
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56245385
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11451811
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96662240
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.84150309
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74295721
9MYC_22102868_ChIP-Seq_BL_Human2.58834575
10* LXR_22292898_ChIP-Seq_THP-1_Human2.50748157
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39037526
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33034509
13RACK7_27058665_Chip-Seq_MCF-7_Human2.28459140
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24593140
15* XRN2_22483619_ChIP-Seq_HELA_Human2.19069532
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09281193
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08041812
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.03283658
19CIITA_25753668_ChIP-Seq_RAJI_Human2.02760558
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01588872
21VDR_21846776_ChIP-Seq_THP-1_Human2.00546303
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99112653
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.95121987
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.93654185
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92461373
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.83456088
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83362478
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79923548
29AR_21909140_ChIP-Seq_LNCAP_Human1.79846202
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.77435506
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76531137
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73529384
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70859709
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70754275
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69789569
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69131161
37CLOCK_20551151_ChIP-Seq_293T_Human1.67854325
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65588072
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65530169
40KDM2B_26808549_Chip-Seq_K562_Human1.63344537
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.61233450
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56372777
43* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55578932
44* TTF2_22483619_ChIP-Seq_HELA_Human1.55272615
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54918687
46VDR_23849224_ChIP-Seq_CD4+_Human1.54050087
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53885791
48* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53770038
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52518067
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52508867
51* GABP_19822575_ChIP-Seq_HepG2_Human1.52273457
52* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51900692
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51486223
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49885062
55DCP1A_22483619_ChIP-Seq_HELA_Human1.48243045
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.48162088
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47529536
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.46939585
59* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45048247
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44636989
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43540568
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43515705
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42233982
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.41882520
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41331929
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38229634
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37863225
68* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36448789
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.35725715
70* P68_20966046_ChIP-Seq_HELA_Human1.35386049
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32191275
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31607266
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31168975
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.29817427
75KDM5A_27292631_Chip-Seq_BREAST_Human1.29181007
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28626795
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28366998
78NCOR1_26117541_ChIP-Seq_K562_Human1.27279154
79* SMC4_20622854_ChIP-Seq_HELA_Human1.26919269
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26192617
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24726853
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24310538
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24303392
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23582345
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23324900
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23026742
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22548311
88CREB1_26743006_Chip-Seq_LNCaP_Human1.22206217
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21506942
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.20457122
91* TFEB_21752829_ChIP-Seq_HELA_Human1.19417463
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.19304701
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18857408
94UTX_26944678_Chip-Seq_JUKART_Human1.18117094
95MAF_26560356_Chip-Seq_TH1_Human1.17732519
96TCF7_22412390_ChIP-Seq_EML_Mouse1.17677530
97* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16244871
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14933524
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14380198
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14236097
101* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13827514
102TP53_22127205_ChIP-Seq_IMR90_Human1.13742604
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12834750
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12359188
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12282420
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12240687
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12240616
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11972002
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10917312
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10814337
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10184535
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10053414
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09406235
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08351116
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07794699
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07448551
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07434593
118* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07316281
119KDM2B_26808549_Chip-Seq_DND41_Human1.07015975
120ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06474146
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06457902
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05373526
123* ELK1_19687146_ChIP-ChIP_HELA_Human1.05371456
124* SPI1_23547873_ChIP-Seq_NB4_Human1.04432441
125ATF3_27146783_Chip-Seq_COLON_Human1.03990322
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03114321
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01004787
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00558328
129* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99248349
130* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98863018
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98443665
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.98060702
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.98013416
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97932233
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96948438
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96321276
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96249070
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95825371
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.94641220
140VDR_24763502_ChIP-Seq_THP-1_Human0.94351961
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93992902
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.93896797
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92878697
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92534308
145ZNF263_19887448_ChIP-Seq_K562_Human0.92181109
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91579609
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91436947
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90426864
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90293271
150SCL_19346495_ChIP-Seq_HPC-7_Human0.88889700
151HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88089259
152HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87800245
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87250033
154* NANOG_21062744_ChIP-ChIP_HESCs_Human0.87110760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.55084342
2MP0003111_abnormal_nucleus_morphology3.34912156
3MP0004957_abnormal_blastocyst_morpholog3.03895670
4MP0003077_abnormal_cell_cycle2.98195878
5MP0010094_abnormal_chromosome_stability2.77854190
6MP0002877_abnormal_melanocyte_morpholog2.76396986
7MP0010352_gastrointestinal_tract_polyps2.62125803
8MP0004858_abnormal_nervous_system2.60991909
9MP0005451_abnormal_body_composition2.58809784
10MP0006054_spinal_hemorrhage2.47465586
11MP0008007_abnormal_cellular_replicative2.45353674
12MP0002796_impaired_skin_barrier2.44252818
13MP0000566_synostosis2.25861598
14MP0004233_abnormal_muscle_weight2.24748255
15MP0005058_abnormal_lysosome_morphology2.17470207
16MP0008057_abnormal_DNA_replication2.15774685
17MP0002396_abnormal_hematopoietic_system2.13052077
18MP0005409_darkened_coat_color2.09722992
19MP0005257_abnormal_intraocular_pressure2.04512730
20MP0003705_abnormal_hypodermis_morpholog1.97606333
21MP0004185_abnormal_adipocyte_glucose1.92706681
22MP0001730_embryonic_growth_arrest1.92699950
23MP0000350_abnormal_cell_proliferation1.90114187
24MP0010030_abnormal_orbit_morphology1.89817555
25MP0008932_abnormal_embryonic_tissue1.87445817
26MP0003453_abnormal_keratinocyte_physiol1.84828995
27MP0004808_abnormal_hematopoietic_stem1.80122470
28MP0008438_abnormal_cutaneous_collagen1.79022263
29MP0004264_abnormal_extraembryonic_tissu1.76069934
30MP0000678_abnormal_parathyroid_gland1.71515300
31MP0008260_abnormal_autophagy1.71148629
32MP0003567_abnormal_fetal_cardiomyocyte1.68604833
33MP0003566_abnormal_cell_adhesion1.68515811
34MP0009278_abnormal_bone_marrow1.65653488
35MP0005076_abnormal_cell_differentiation1.63722721
36MP0008058_abnormal_DNA_repair1.59226640
37MP0009840_abnormal_foam_cell1.57909493
38MP0000490_abnormal_crypts_of1.57394478
39MP0001672_abnormal_embryogenesis/_devel1.53983639
40MP0005380_embryogenesis_phenotype1.53983639
41MP0010307_abnormal_tumor_latency1.53301306
42MP0001697_abnormal_embryo_size1.53251781
43MP0003984_embryonic_growth_retardation1.47997341
44MP0002088_abnormal_embryonic_growth/wei1.45855893
45MP0002085_abnormal_embryonic_tissue1.45752402
46MP0000467_abnormal_esophagus_morphology1.43707974
47MP0002080_prenatal_lethality1.40645978
48MP0000537_abnormal_urethra_morphology1.38870986
49MP0003123_paternal_imprinting1.38682535
50MP0002084_abnormal_developmental_patter1.38542044
51MP0001545_abnormal_hematopoietic_system1.36160409
52MP0005397_hematopoietic_system_phenotyp1.36160409
53MP0002086_abnormal_extraembryonic_tissu1.33449336
54MP0003279_aneurysm1.31449226
55MP0004197_abnormal_fetal_growth/weight/1.31290815
56MP0005023_abnormal_wound_healing1.31087251
57MP0003763_abnormal_thymus_physiology1.31078113
58MP0009672_abnormal_birth_weight1.28984751
59MP0000579_abnormal_nail_morphology1.26161541
60MP0000733_abnormal_muscle_development1.24578104
61MP0003191_abnormal_cellular_cholesterol1.23481381
62MP0005623_abnormal_meninges_morphology1.22849168
63MP0003300_gastrointestinal_ulcer1.19998715
64MP0002249_abnormal_larynx_morphology1.18041248
65MP0002019_abnormal_tumor_incidence1.17729457
66MP0000703_abnormal_thymus_morphology1.15712666
67MP0010368_abnormal_lymphatic_system1.15338586
68MP0003941_abnormal_skin_development1.14730050
69MP0000313_abnormal_cell_death1.14458439
70MP0009333_abnormal_splenocyte_physiolog1.14275338
71MP0001958_emphysema1.14172770
72MP0003786_premature_aging1.14145377
73MP0002098_abnormal_vibrissa_morphology1.13202667
74MP0000685_abnormal_immune_system1.12486165
75MP0001216_abnormal_epidermal_layer1.12235648
76MP0000428_abnormal_craniofacial_morphol1.12055730
77MP0009053_abnormal_anal_canal1.10926548
78MP0002398_abnormal_bone_marrow1.08849311
79MP0000003_abnormal_adipose_tissue1.06247589
80MP0000858_altered_metastatic_potential1.05170709
81MP0005666_abnormal_adipose_tissue1.05108942
82MP0001915_intracranial_hemorrhage1.04525878
83MP0005275_abnormal_skin_tensile1.03768306
84MP0004947_skin_inflammation1.01780887
85MP0004272_abnormal_basement_membrane1.00952225
86MP0000762_abnormal_tongue_morphology1.00712099
87MP0003115_abnormal_respiratory_system1.00214959
88MP0002722_abnormal_immune_system0.98862782
89MP0002925_abnormal_cardiovascular_devel0.97083988
90MP0001293_anophthalmia0.96313275
91MP0003172_abnormal_lysosome_physiology0.95755896
92MP0009931_abnormal_skin_appearance0.95569559
93MP0010234_abnormal_vibrissa_follicle0.93731050
94MP0002254_reproductive_system_inflammat0.92472662
95MP0005375_adipose_tissue_phenotype0.92336078
96MP0003091_abnormal_cell_migration0.91149019
97MP0005503_abnormal_tendon_morphology0.90322561
98MP0003119_abnormal_digestive_system0.90202194
99MP0002896_abnormal_bone_mineralization0.89941441
100MP0001849_ear_inflammation0.89759536
101MP0000689_abnormal_spleen_morphology0.87436807
102MP0000767_abnormal_smooth_muscle0.86421872
103MP0004782_abnormal_surfactant_physiolog0.85934078
104MP0000377_abnormal_hair_follicle0.84336267
105MP0010771_integument_phenotype0.84297426
106MP0000462_abnormal_digestive_system0.82035385
107MP0002932_abnormal_joint_morphology0.81757848
108MP0003942_abnormal_urinary_system0.81749370
109MP0003283_abnormal_digestive_organ0.80723267
110MP0002429_abnormal_blood_cell0.80434431
111MP0003448_altered_tumor_morphology0.79578604
112MP0009384_cardiac_valve_regurgitation0.79320331
113MP0001879_abnormal_lymphatic_vessel0.78665691
114MP0001873_stomach_inflammation0.78362147
115MP0001661_extended_life_span0.78338530
116MP0002111_abnormal_tail_morphology0.78253924
117MP0000534_abnormal_ureter_morphology0.77374885
118MP0005360_urolithiasis0.76296578
119MP0000750_abnormal_muscle_regeneration0.75815240
120MP0001881_abnormal_mammary_gland0.75467954
121MP0001348_abnormal_lacrimal_gland0.74871972
122MP0000465_gastrointestinal_hemorrhage0.74623991
123MP0009379_abnormal_foot_pigmentation0.74555639
124MP0003935_abnormal_craniofacial_develop0.73877085
125MP0005621_abnormal_cell_physiology0.73741043
126MP0000477_abnormal_intestine_morphology0.73672058
127MP0005508_abnormal_skeleton_morphology0.73670425
128MP0003121_genomic_imprinting0.72804073
129MP0002405_respiratory_system_inflammati0.72165659
130MP0002089_abnormal_postnatal_growth/wei0.70893842
131MP0003329_amyloid_beta_deposits0.70864301
132MP0000266_abnormal_heart_morphology0.70483106
133MP0006138_congestive_heart_failure0.70446332
134MP0000627_abnormal_mammary_gland0.70438144
135MP0010630_abnormal_cardiac_muscle0.70412461
136MP0005384_cellular_phenotype0.70390014
137MP0002092_abnormal_eye_morphology0.70249158
138MP0003385_abnormal_body_wall0.69962892
139MP0003828_pulmonary_edema0.69756640
140MP0001175_abnormal_lung_morphology0.69730048
141MP0003315_abnormal_perineum_morphology0.69660094
142MP0000716_abnormal_immune_system0.69523856
143MP0000049_abnormal_middle_ear0.69448964
144MP0001614_abnormal_blood_vessel0.69191479
145MP0002060_abnormal_skin_morphology0.69070219
146MP0003937_abnormal_limbs/digits/tail_de0.68759094
147MP0005501_abnormal_skin_physiology0.68269329
148MP0004133_heterotaxia0.67521704
149MP0002166_altered_tumor_susceptibility0.67055787

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)3.63514648
2Protrusio acetabuli (HP:0003179)3.47807144
3Reticulocytopenia (HP:0001896)3.33756257
4Vertebral compression fractures (HP:0002953)2.93204655
5Birth length less than 3rd percentile (HP:0003561)2.89537013
6Asymmetry of the thorax (HP:0001555)2.88555021
7Ankle contracture (HP:0006466)2.84500458
8Abnormality of cells of the erythroid lineage (HP:0012130)2.83423323
9Distal lower limb amyotrophy (HP:0008944)2.71621799
10Disproportionate tall stature (HP:0001519)2.71445310
11Achilles tendon contracture (HP:0001771)2.70233683
12Broad face (HP:0000283)2.70070744
13Long palpebral fissure (HP:0000637)2.67922152
14Flat acetabular roof (HP:0003180)2.67508175
15Thin bony cortex (HP:0002753)2.65933151
16Upper limb amyotrophy (HP:0009129)2.62939067
17Distal upper limb amyotrophy (HP:0007149)2.62939067
18Abnormal number of erythroid precursors (HP:0012131)2.61177355
19Ependymoma (HP:0002888)2.59269794
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58760988
21Short 4th metacarpal (HP:0010044)2.58760988
22Breast hypoplasia (HP:0003187)2.50252388
23Colon cancer (HP:0003003)2.50147846
24Fragile skin (HP:0001030)2.48456424
25Premature rupture of membranes (HP:0001788)2.45684684
26Abnormality of the Achilles tendon (HP:0005109)2.44873064
27Insomnia (HP:0100785)2.41350506
28Trismus (HP:0000211)2.40454253
29Abnormal number of incisors (HP:0011064)2.36881809
30Abnormality of the calcaneus (HP:0008364)2.34850244
31Patellar aplasia (HP:0006443)2.33356906
32Ankyloglossia (HP:0010296)2.30385543
33Cerebral aneurysm (HP:0004944)2.28305010
34Shallow orbits (HP:0000586)2.27825088
35Distal lower limb muscle weakness (HP:0009053)2.26000417
36Spinal rigidity (HP:0003306)2.24159441
37Blue sclerae (HP:0000592)2.23214333
38Natal tooth (HP:0000695)2.21057779
39Increased nuchal translucency (HP:0010880)2.20891980
40Aplasia/Hypoplasia of the patella (HP:0006498)2.19897104
41Abnormality of the distal phalanges of the toes (HP:0010182)2.19660384
42Deviation of the thumb (HP:0009603)2.19626125
43Abnormal gallbladder physiology (HP:0012438)2.15610160
44Cholecystitis (HP:0001082)2.15610160
45Atrophic scars (HP:0001075)2.15533499
46High pitched voice (HP:0001620)2.14860482
47Advanced eruption of teeth (HP:0006288)2.14162862
48Abnormality of oral frenula (HP:0000190)2.13614919
49Increased density of long bones (HP:0006392)2.12059285
50Proximal placement of thumb (HP:0009623)2.10905542
51Slender long bone (HP:0003100)2.10515832
52Hyperacusis (HP:0010780)2.09724558
53Thrombocytosis (HP:0001894)2.08391344
54Centrally nucleated skeletal muscle fibers (HP:0003687)2.07260650
55Biconcave vertebral bodies (HP:0004586)2.05600485
56Mildly elevated creatine phosphokinase (HP:0008180)2.03448107
57Degeneration of anterior horn cells (HP:0002398)2.02816371
58Abnormality of the anterior horn cell (HP:0006802)2.02816371
59Wrist flexion contracture (HP:0001239)2.02490306
60Short nail (HP:0001799)2.01442367
61Neoplasm of the pancreas (HP:0002894)2.01358074
62Atresia of the external auditory canal (HP:0000413)2.00733828
63Hemorrhage of the eye (HP:0011885)2.00593189
64Obstructive sleep apnea (HP:0002870)2.00176805
65Aortic aneurysm (HP:0004942)1.99524033
6611 pairs of ribs (HP:0000878)1.98082588
67Back pain (HP:0003418)1.97381459
68Reticulocytosis (HP:0001923)1.97021006
69Hand muscle atrophy (HP:0009130)1.94370797
70Premature skin wrinkling (HP:0100678)1.93976178
71Wormian bones (HP:0002645)1.93473262
72Renal duplication (HP:0000075)1.93173741
73Myelodysplasia (HP:0002863)1.91829754
74Oral leukoplakia (HP:0002745)1.91038895
75Bicuspid aortic valve (HP:0001647)1.90872234
76Pallor (HP:0000980)1.90661345
77Mitral regurgitation (HP:0001653)1.90511355
78Abnormality of the thoracic spine (HP:0100711)1.90389954
79Elbow flexion contracture (HP:0002987)1.90260894
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.89769316
81Bowel diverticulosis (HP:0005222)1.88939713
82Lower limb amyotrophy (HP:0007210)1.87310455
83Hyperparathyroidism (HP:0000843)1.87268616
84Basal cell carcinoma (HP:0002671)1.86845227
85Missing ribs (HP:0000921)1.86295574
86Bladder diverticulum (HP:0000015)1.86119895
87Genu recurvatum (HP:0002816)1.84023834
88Aplastic anemia (HP:0001915)1.83237171
89Deep venous thrombosis (HP:0002625)1.82904096
90Rough bone trabeculation (HP:0100670)1.82365513
91Mesangial abnormality (HP:0001966)1.82086358
92Multiple enchondromatosis (HP:0005701)1.81796249
93Astrocytoma (HP:0009592)1.79958391
94Abnormality of the astrocytes (HP:0100707)1.79958391
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.79721412
96Osteolytic defects of the hand bones (HP:0009699)1.79721412
97Pterygium (HP:0001059)1.79267857
98Absent thumb (HP:0009777)1.78239407
99Soft skin (HP:0000977)1.78017741
100Cervical subluxation (HP:0003308)1.77375016
101Gastrointestinal carcinoma (HP:0002672)1.77278118
102Malignant gastrointestinal tract tumors (HP:0006749)1.77278118
103Stridor (HP:0010307)1.76805515
104Patellar dislocation (HP:0002999)1.76282658
105J-shaped sella turcica (HP:0002680)1.76190283
106Abnormality of the 4th metacarpal (HP:0010012)1.75676894
107Absent radius (HP:0003974)1.75346686
108Calcaneovalgus deformity (HP:0001848)1.74265947
109Prominent nose (HP:0000448)1.74008433
110Pointed chin (HP:0000307)1.73357777
111Short middle phalanx of the 5th finger (HP:0004220)1.72596429
112Arnold-Chiari malformation (HP:0002308)1.72116462
113Medulloblastoma (HP:0002885)1.72020636
114Abnormality of the peritoneum (HP:0002585)1.70920880
115Polygenic inheritance (HP:0010982)1.70703879
116Aortic dissection (HP:0002647)1.70678178
117Difficulty climbing stairs (HP:0003551)1.70540582
118Spinal cord compression (HP:0002176)1.70474430
119Generalized amyotrophy (HP:0003700)1.70269264
120Abnormality of the acetabulum (HP:0003170)1.70226920
121Turricephaly (HP:0000262)1.69267737
122Increased variability in muscle fiber diameter (HP:0003557)1.69128356
123Skin tags (HP:0010609)1.68497376
124Neonatal death (HP:0003811)1.66624618
125Dilatation of the ascending aorta (HP:0005111)1.66394822
126Abnormality of dentin (HP:0010299)1.65964402
127Duodenal stenosis (HP:0100867)1.65838016
128Small intestinal stenosis (HP:0012848)1.65838016
129Cutaneous melanoma (HP:0012056)1.65756395
130Abnormal ossification of hand bones (HP:0005921)1.65494450
131Thin ribs (HP:0000883)1.65352778
132Aplasia involving forearm bones (HP:0009822)1.65041266
133Absent forearm bone (HP:0003953)1.65041266
134Preauricular skin tag (HP:0000384)1.64861100
135Dysmetric saccades (HP:0000641)1.64832171
136Long eyelashes (HP:0000527)1.64813941
137Macrocytic anemia (HP:0001972)1.64425722
138Squamous cell carcinoma (HP:0002860)1.64007051
139Rectal prolapse (HP:0002035)1.63878710
140Short 5th finger (HP:0009237)1.63343520
141Syringomyelia (HP:0003396)1.62550783
142Spinal cord lesions (HP:0100561)1.62550783
143Tracheoesophageal fistula (HP:0002575)1.62332993
144Aneurysm (HP:0002617)1.61374659
145Meckel diverticulum (HP:0002245)1.59412849
146Nonimmune hydrops fetalis (HP:0001790)1.59255099
147Arterial tortuosity (HP:0005116)1.59159587
148Ectopic kidney (HP:0000086)1.58711731
149Ulnar bowing (HP:0003031)1.58093384
150Chromsome breakage (HP:0040012)1.57528607
151Mitral valve prolapse (HP:0001634)1.57332537
152Abnormality of nail color (HP:0100643)1.57040208
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56491377
154Trigonocephaly (HP:0000243)1.56189987
155Congenital glaucoma (HP:0001087)1.55698290
156Elfin facies (HP:0004428)1.55412040
157Optic nerve coloboma (HP:0000588)1.55398343
158Overriding aorta (HP:0002623)1.55314613
159Abnormality of carpal bone ossification (HP:0006257)1.55147820
160Abnormality of the umbilical cord (HP:0010881)1.54883942
161Coxa vara (HP:0002812)1.54634543
162Deformed tarsal bones (HP:0008119)1.54512010
163Abnormality of skeletal muscle fiber size (HP:0012084)1.54161270
164Abnormality of the ileum (HP:0001549)1.54011345
165Microretrognathia (HP:0000308)1.53638376
166Increased connective tissue (HP:0009025)1.53484474
167Vascular tortuosity (HP:0004948)1.53035561
168Hematochezia (HP:0002573)1.53001772
169Abnormality of the fingertips (HP:0001211)1.52455422
170Cellulitis (HP:0100658)1.51165068
171Joint laxity (HP:0001388)1.50612697
172Abdominal distention (HP:0003270)1.49951282
173Sparse lateral eyebrow (HP:0005338)1.49106102
174Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.49029115
175Premature graying of hair (HP:0002216)1.48523417
176Esophageal varix (HP:0002040)1.47713805
177Renal cell carcinoma (HP:0005584)1.47518172
178Hallux valgus (HP:0001822)1.47385258
179Glossoptosis (HP:0000162)1.46969071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41947158
2SMG13.53285538
3CDC73.37899379
4EEF2K3.10702534
5SIK13.09698496
6IRAK32.96350625
7WEE12.84866610
8PRPF4B2.82652866
9NEK22.74542352
10TRIB32.64347463
11PKN22.52689687
12MAP3K102.48973591
13MST1R2.11425412
14CDK122.03070230
15TGFBR12.02196638
16RPS6KA41.98653473
17FGFR41.94381490
18RIPK11.85554211
19PAK41.78502770
20STK101.76112804
21EPHA21.72931498
22TTN1.71381834
23TESK21.70650608
24TTK1.67218305
25CDK71.63815722
26SCYL21.62225418
27RPS6KB21.60306476
28EIF2AK11.60166354
29LRRK21.55603320
30MAP4K11.52688043
31TLK11.50826289
32MAP3K81.49610765
33PASK1.48256480
34ATR1.35334687
35CDK41.33673110
36PLK11.33635382
37NME21.31998226
38AURKB1.31401078
39NEK11.28739302
40DYRK31.28117051
41MET1.26067025
42NTRK11.25326308
43KDR1.22408981
44KSR21.20724927
45SRPK11.20660088
46BRSK21.19970704
47ARAF1.16110102
48FLT31.13545528
49ERN11.12323824
50TSSK61.10139828
51MAP3K31.06800479
52JAK31.05387736
53PDGFRA1.04248277
54TESK10.99626879
55PTK60.96970599
56CHEK10.96610423
57AURKA0.95320035
58BTK0.95256329
59LMTK20.95057117
60MKNK10.94763257
61MAPKAPK30.94591762
62CHEK20.93949241
63ACVR1B0.92695348
64BRD40.91364346
65ILK0.91238339
66EPHB10.88969882
67PRKD30.88622670
68RPS6KA20.87862578
69MAP3K130.85809406
70MTOR0.84718289
71BRSK10.84305685
72PAK20.82103731
73CDK80.81938162
74PRKD20.81341010
75ZAP700.81202206
76MAP2K20.81147066
77CDK60.80486934
78PIM10.79261054
79PAK10.78380277
80MAP3K90.76280802
81STK40.74820937
82PDPK10.74702893
83TGFBR20.73722514
84PRKG20.73146338
85BRAF0.73096404
86PIM20.72169967
87IRAK20.71834374
88ALK0.71082113
89MAP2K30.70136927
90CDK20.70061761
91MAP3K20.69910014
92CDC42BPA0.69200517
93STK240.68455258
94PRKCI0.68203421
95MAP3K10.67855348
96LATS20.67387822
97MARK20.66790499
98RPS6KC10.66636835
99RPS6KL10.66636835
100DYRK1B0.61743054
101ATM0.61505505
102GRK60.60994230
103PLK30.60159860
104RET0.57128904
105TYRO30.56297276
106BLK0.55907335
107FGFR10.55896489
108EIF2AK30.54392329
109BMX0.54388965
110TAOK10.54296794
111MKNK20.53346384
112EPHB20.52738618
113AKT20.52092523
114MELK0.50254095
115MAP3K110.49576891
116IRAK40.49035348
117LIMK10.49020735
118TIE10.48191281
119PLK40.46345240
120TYK20.44075812
121CDK90.43132325
122CDK10.42907905
123MAP3K60.42701243
124CLK10.42536906
125KIT0.42270968
126MAPKAPK20.41645299
127DDR20.40619579
128MARK30.40089097
129RPS6KA60.39774830
130STK30.39543493
131TAOK20.38414914
132ICK0.38337829
133HIPK20.35932588
134CHUK0.35429860
135PDGFRB0.32811976
136TBK10.32780914
137MAPK110.31805233
138VRK10.31662275
139PTK20.31554122
140CAMK1D0.31359685
141CSNK2A20.30467787
142CDK11A0.29844064
143LATS10.29278636
144MOS0.27956408
145SIK30.27586801
146CDK150.26625317
147MAP2K10.24666335
148RPS6KA10.24145065

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94207788
2Mismatch repair_Homo sapiens_hsa034303.38363088
3Spliceosome_Homo sapiens_hsa030402.76097672
4Ribosome_Homo sapiens_hsa030102.68257440
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.66358146
6Base excision repair_Homo sapiens_hsa034102.63667746
7Cell cycle_Homo sapiens_hsa041102.50103745
8RNA transport_Homo sapiens_hsa030132.49551673
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34516157
10Homologous recombination_Homo sapiens_hsa034402.25037661
11Nucleotide excision repair_Homo sapiens_hsa034202.20030617
12Other glycan degradation_Homo sapiens_hsa005112.19200476
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94224557
14Biosynthesis of amino acids_Homo sapiens_hsa012301.85841775
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.81527755
16One carbon pool by folate_Homo sapiens_hsa006701.78778018
17RNA polymerase_Homo sapiens_hsa030201.78145723
18Fructose and mannose metabolism_Homo sapiens_hsa000511.77101959
19p53 signaling pathway_Homo sapiens_hsa041151.75146410
20mRNA surveillance pathway_Homo sapiens_hsa030151.74674273
21Galactose metabolism_Homo sapiens_hsa000521.72549848
22Proteasome_Homo sapiens_hsa030501.60544180
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48381941
24Fanconi anemia pathway_Homo sapiens_hsa034601.48124177
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47265560
26Prion diseases_Homo sapiens_hsa050201.46004213
27Pyrimidine metabolism_Homo sapiens_hsa002401.45540501
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41422652
29Small cell lung cancer_Homo sapiens_hsa052221.41133608
30RNA degradation_Homo sapiens_hsa030181.39858256
31Non-homologous end-joining_Homo sapiens_hsa034501.35663960
32Arginine biosynthesis_Homo sapiens_hsa002201.34839049
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26310007
34HTLV-I infection_Homo sapiens_hsa051661.26306366
35Chronic myeloid leukemia_Homo sapiens_hsa052201.23619948
36Insulin signaling pathway_Homo sapiens_hsa049101.22986427
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.22843736
38MicroRNAs in cancer_Homo sapiens_hsa052061.22583763
39ErbB signaling pathway_Homo sapiens_hsa040121.19983653
40Viral carcinogenesis_Homo sapiens_hsa052031.18851363
41Herpes simplex infection_Homo sapiens_hsa051681.18760461
42Epstein-Barr virus infection_Homo sapiens_hsa051691.18649148
43Antigen processing and presentation_Homo sapiens_hsa046121.14673348
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13622737
45Notch signaling pathway_Homo sapiens_hsa043301.09788901
46AMPK signaling pathway_Homo sapiens_hsa041521.08461833
47Sulfur relay system_Homo sapiens_hsa041221.08111204
48Viral myocarditis_Homo sapiens_hsa054161.06205827
49Bladder cancer_Homo sapiens_hsa052191.06037573
50Basal cell carcinoma_Homo sapiens_hsa052171.05257060
51Carbon metabolism_Homo sapiens_hsa012001.05224260
52Basal transcription factors_Homo sapiens_hsa030221.05095410
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04770304
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01520080
55Hippo signaling pathway_Homo sapiens_hsa043901.01223351
56Primary immunodeficiency_Homo sapiens_hsa053400.98136276
57Apoptosis_Homo sapiens_hsa042100.97515927
58Shigellosis_Homo sapiens_hsa051310.97354776
59Amoebiasis_Homo sapiens_hsa051460.94184917
60Thyroid cancer_Homo sapiens_hsa052160.92790702
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92343444
62Oocyte meiosis_Homo sapiens_hsa041140.91843029
63Adherens junction_Homo sapiens_hsa045200.90692840
64Proteoglycans in cancer_Homo sapiens_hsa052050.89676953
65Colorectal cancer_Homo sapiens_hsa052100.89595678
66Acute myeloid leukemia_Homo sapiens_hsa052210.89020083
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88307400
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.87798783
69Lysine degradation_Homo sapiens_hsa003100.84680983
70Estrogen signaling pathway_Homo sapiens_hsa049150.84279430
71Hepatitis C_Homo sapiens_hsa051600.83883589
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83045473
73Focal adhesion_Homo sapiens_hsa045100.82749447
74TGF-beta signaling pathway_Homo sapiens_hsa043500.80717485
75B cell receptor signaling pathway_Homo sapiens_hsa046620.80572718
76Vitamin B6 metabolism_Homo sapiens_hsa007500.79557676
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79389663
78Hepatitis B_Homo sapiens_hsa051610.79266079
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77938052
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77932306
81Measles_Homo sapiens_hsa051620.76408486
82Vibrio cholerae infection_Homo sapiens_hsa051100.76055630
83Prolactin signaling pathway_Homo sapiens_hsa049170.75979238
84GnRH signaling pathway_Homo sapiens_hsa049120.75054840
85Endocytosis_Homo sapiens_hsa041440.74967602
86Choline metabolism in cancer_Homo sapiens_hsa052310.74624340
87Pancreatic cancer_Homo sapiens_hsa052120.74570821
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.74358804
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.73954742
90Legionellosis_Homo sapiens_hsa051340.73717864
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.73699571
92Pathways in cancer_Homo sapiens_hsa052000.73646139
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73305184
94ECM-receptor interaction_Homo sapiens_hsa045120.71582392
95Systemic lupus erythematosus_Homo sapiens_hsa053220.71274729
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.70661733
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69807872
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69217677
99HIF-1 signaling pathway_Homo sapiens_hsa040660.69151110
100Hedgehog signaling pathway_Homo sapiens_hsa043400.68515310
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68298780
102Toxoplasmosis_Homo sapiens_hsa051450.67621617
103Leishmaniasis_Homo sapiens_hsa051400.67575711
104Inositol phosphate metabolism_Homo sapiens_hsa005620.66987409
105Purine metabolism_Homo sapiens_hsa002300.65915543
106Non-small cell lung cancer_Homo sapiens_hsa052230.63677512
107Endometrial cancer_Homo sapiens_hsa052130.62370801
108Insulin resistance_Homo sapiens_hsa049310.62361951
109mTOR signaling pathway_Homo sapiens_hsa041500.61940053
110Influenza A_Homo sapiens_hsa051640.61840409
111VEGF signaling pathway_Homo sapiens_hsa043700.60194144
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58945594
113Hematopoietic cell lineage_Homo sapiens_hsa046400.57714474
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57690597
115Prostate cancer_Homo sapiens_hsa052150.57220602
116Platelet activation_Homo sapiens_hsa046110.56705485
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54144534
118Salmonella infection_Homo sapiens_hsa051320.54125641
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53393925
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.52941480
121Tight junction_Homo sapiens_hsa045300.52927868
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52782538
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.52692075
124Lysosome_Homo sapiens_hsa041420.51726102
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50997029
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.49910485
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48987890
128Rap1 signaling pathway_Homo sapiens_hsa040150.48891280
129N-Glycan biosynthesis_Homo sapiens_hsa005100.48593903
130Melanogenesis_Homo sapiens_hsa049160.48342127
131Phenylalanine metabolism_Homo sapiens_hsa003600.48333431
132TNF signaling pathway_Homo sapiens_hsa046680.48221983
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46890094
134T cell receptor signaling pathway_Homo sapiens_hsa046600.44330763
135Pentose phosphate pathway_Homo sapiens_hsa000300.44039121
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43738938
137Glucagon signaling pathway_Homo sapiens_hsa049220.43327823
138Axon guidance_Homo sapiens_hsa043600.42797830
139Wnt signaling pathway_Homo sapiens_hsa043100.42446136
140Osteoclast differentiation_Homo sapiens_hsa043800.41569527
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41467745
142Melanoma_Homo sapiens_hsa052180.40500244
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39973306
144Glioma_Homo sapiens_hsa052140.39894970
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39106842
146Renal cell carcinoma_Homo sapiens_hsa052110.37612768

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