TRAJ16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of uterine smooth muscle contraction (GO:0070474)9.22402432
2tachykinin receptor signaling pathway (GO:0007217)8.12170687
3cytidine deamination (GO:0009972)7.72607875
4cytidine metabolic process (GO:0046087)7.72607875
5cytidine catabolic process (GO:0006216)7.72607875
6regulation of uterine smooth muscle contraction (GO:0070472)7.17757191
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.11263640
8pyrimidine ribonucleoside catabolic process (GO:0046133)6.73683399
9sperm capacitation (GO:0048240)6.68481185
10DNA deamination (GO:0045006)5.95775478
11negative regulation of T cell apoptotic process (GO:0070233)5.77463540
12negative T cell selection (GO:0043383)5.72395550
13protein-chromophore linkage (GO:0018298)5.62764087
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.60740662
15regulation of gamma-delta T cell differentiation (GO:0045586)5.42876768
16positive T cell selection (GO:0043368)5.39390606
17Arp2/3 complex-mediated actin nucleation (GO:0034314)5.39166975
18T cell migration (GO:0072678)5.33770914
19positive regulation of gamma-delta T cell activation (GO:0046645)5.31318300
20negative regulation of stress fiber assembly (GO:0051497)5.14382478
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10051109
22actin nucleation (GO:0045010)4.81934891
23regulation of gonadotropin secretion (GO:0032276)4.74469810
24multicellular organism reproduction (GO:0032504)4.67905325
25response to pheromone (GO:0019236)4.65869308
26regulation of gamma-delta T cell activation (GO:0046643)4.59932890
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.43402212
28positive regulation of natural killer cell mediated immunity (GO:0002717)4.42897522
29negative thymic T cell selection (GO:0045060)4.38732482
30positive thymic T cell selection (GO:0045059)4.37226319
31rhodopsin mediated signaling pathway (GO:0016056)4.34204596
32interferon-gamma production (GO:0032609)4.33984151
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.28400345
34positive regulation of T cell differentiation in thymus (GO:0033089)4.20527378
35negative regulation of actin filament bundle assembly (GO:0032232)4.20328558
36regulation of T cell receptor signaling pathway (GO:0050856)4.15075669
37positive regulation of smooth muscle contraction (GO:0045987)4.09955716
38regulation of natural killer cell mediated immunity (GO:0002715)4.08775015
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.08775015
40positive regulation of interleukin-4 production (GO:0032753)4.01027791
41positive regulation of vascular permeability (GO:0043117)3.99271518
42negative regulation of cell killing (GO:0031342)3.95471775
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95471775
44regulation of T cell apoptotic process (GO:0070232)3.92617628
45signal complex assembly (GO:0007172)3.91600227
46positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.87300272
47thymic T cell selection (GO:0045061)3.84588975
48purine nucleotide salvage (GO:0032261)3.84520436
49T cell receptor signaling pathway (GO:0050852)3.71389212
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70098124
51T cell selection (GO:0045058)3.69796870
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.66227071
53positive regulation of interleukin-17 production (GO:0032740)3.63385189
54regulation of leukocyte mediated cytotoxicity (GO:0001910)3.59505717
55negative regulation of lymphocyte apoptotic process (GO:0070229)3.58305207
56lymphocyte migration (GO:0072676)3.57166860
57positive regulation of protein homodimerization activity (GO:0090073)3.54464278
58histone H3-K36 demethylation (GO:0070544)3.51675947
59positive regulation of cell killing (GO:0031343)3.51167917
60tolerance induction (GO:0002507)3.50239970
61pyrimidine nucleoside catabolic process (GO:0046135)3.45699204
62negative regulation of viral genome replication (GO:0045071)3.43436746
63negative regulation of thymocyte apoptotic process (GO:0070244)3.38572392
64regulation of regulatory T cell differentiation (GO:0045589)3.37005781
65response to interferon-beta (GO:0035456)3.36599107
66negative regulation of T cell receptor signaling pathway (GO:0050860)3.35042348
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34625745
68mature B cell differentiation involved in immune response (GO:0002313)3.32475749
69antigen processing and presentation via MHC class Ib (GO:0002475)3.29786829
70antigen processing and presentation of endogenous antigen (GO:0019883)3.27422875
71regulation of cell killing (GO:0031341)3.26450585
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24191729
73blood vessel maturation (GO:0001955)3.23965708
74positive regulation of macrophage differentiation (GO:0045651)3.21228369
75positive regulation of muscle contraction (GO:0045933)3.19904385
76reproduction (GO:0000003)3.18438328
77heart trabecula morphogenesis (GO:0061384)3.17922672
78positive regulation of lamellipodium assembly (GO:0010592)3.17684932
79regulation of defense response to virus by virus (GO:0050690)3.14645023
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13357198
81macrophage chemotaxis (GO:0048246)3.13046094
82Peyers patch development (GO:0048541)3.07943342
83mucosal-associated lymphoid tissue development (GO:0048537)3.07943342
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04034486
85T cell costimulation (GO:0031295)3.03599331
86regulation of interleukin-2 biosynthetic process (GO:0045076)3.03459322
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03315090
88regulation of T cell mediated cytotoxicity (GO:0001914)3.01740960
89lymphocyte costimulation (GO:0031294)2.99957782
90hepatocyte apoptotic process (GO:0097284)2.99477317
91regulation of T cell tolerance induction (GO:0002664)2.98973966
92positive regulation of interleukin-8 secretion (GO:2000484)2.98497556
93positive regulation of tolerance induction (GO:0002645)2.97687852
94regulation of thymocyte apoptotic process (GO:0070243)2.97687787
95negative regulation by host of viral transcription (GO:0043922)2.97079124
96positive regulation of T cell cytokine production (GO:0002726)2.96178304
97positive regulation of granulocyte differentiation (GO:0030854)2.94494092
98purine deoxyribonucleotide catabolic process (GO:0009155)2.94325430
99cellular response to interleukin-15 (GO:0071350)2.93728212
100leukocyte aggregation (GO:0070486)2.89281668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.94101342
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.98964467
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.22722546
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.95989538
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.37479509
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69961405
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.30440034
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.24157919
9RUNX_20019798_ChIP-Seq_JUKART_Human3.19557786
10MYB_26560356_Chip-Seq_TH2_Human2.85130252
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74971448
12E2F7_22180533_ChIP-Seq_HELA_Human2.57616911
13GATA3_27048872_Chip-Seq_THYMUS_Human2.47570282
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45316913
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38660307
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38280219
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.34778884
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.15363924
19MYB_26560356_Chip-Seq_TH1_Human2.15198688
20UTX_26944678_Chip-Seq_JUKART_Human2.07866571
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98795691
22GATA3_26560356_Chip-Seq_TH2_Human1.91561337
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83566885
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71462699
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.57945566
26MAF_26560356_Chip-Seq_TH1_Human1.52255412
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48861064
28BCL6_27268052_Chip-Seq_Bcells_Human1.45315053
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43587656
30EGR1_19032775_ChIP-ChIP_M12_Human1.42428225
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41294947
32VDR_22108803_ChIP-Seq_LS180_Human1.34256640
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29187606
34TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23394103
35SCL_19346495_ChIP-Seq_HPC-7_Human1.20545701
36VDR_23849224_ChIP-Seq_CD4+_Human1.15365839
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14671381
38SA1_27219007_Chip-Seq_Bcells_Human1.13925037
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11583722
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10706590
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.10013785
42EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08657904
43AR_20517297_ChIP-Seq_VCAP_Human1.08644484
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08503429
45MAF_26560356_Chip-Seq_TH2_Human1.08243964
46ERG_20517297_ChIP-Seq_VCAP_Human1.04948283
47RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03448929
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03089125
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02197876
50TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01217407
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00166305
52GATA6_21074721_ChIP-Seq_CACO-2_Human0.99913479
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99636316
54SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96032903
55CIITA_25753668_ChIP-Seq_RAJI_Human0.94887422
56CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94003855
57TP63_17297297_ChIP-ChIP_HaCaT_Human0.93973861
58TAF2_19829295_ChIP-Seq_ESCs_Human0.93959837
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93288048
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92849872
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90039053
62NFYB_21822215_ChIP-Seq_K562_Human0.89514498
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89476156
64CTCF_18555785_Chip-Seq_ESCs_Mouse0.88634604
65SPI1_23547873_ChIP-Seq_NB4_Human0.88337999
66TP53_22573176_ChIP-Seq_HFKS_Human0.87954429
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87353300
68PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87295212
69ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86706330
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86480088
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86456814
72RBPJ_21746931_ChIP-Seq_IB4_Human0.86241294
73BCOR_27268052_Chip-Seq_Bcells_Human0.86199228
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.85370679
75HNFA_21074721_ChIP-Seq_CACO-2_Human0.84036607
76RXR_22108803_ChIP-Seq_LS180_Human0.83991484
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.82099256
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.81693469
79NMYC_18555785_Chip-Seq_ESCs_Mouse0.81257129
80PHF8_20622853_ChIP-Seq_HELA_Human0.81253267
81OCT4_18555785_Chip-Seq_ESCs_Mouse0.81172288
82NCOR_22424771_ChIP-Seq_293T_Human0.81141328
83ETV1_20927104_ChIP-Seq_GIST48_Human0.80322506
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79483945
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79323929
86IRF1_19129219_ChIP-ChIP_H3396_Human0.77358428
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76995984
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75745626
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75428951
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.74753578
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74714692
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74581933
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74496748
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.74126838
95RUNX1_27457419_Chip-Seq_LIVER_Mouse0.73882159
96STAT1_20625510_ChIP-Seq_HELA_Human0.73435545
97SPI1_20517297_ChIP-Seq_HL60_Human0.73380771
98NANOG_20526341_ChIP-Seq_ESCs_Human0.72079490
99IRF8_27001747_Chip-Seq_BMDM_Mouse0.71951671
100RAC3_21632823_ChIP-Seq_H3396_Human0.71940905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex6.83176432
2MP0005671_abnormal_response_to4.31477313
3MP0003763_abnormal_thymus_physiology3.45650363
4MP0003806_abnormal_nucleotide_metabolis3.27498910
5MP0001764_abnormal_homeostasis3.24494606
6MP0003950_abnormal_plasma_membrane3.18672628
7MP0000372_irregular_coat_pigmentation3.02109858
8MP0009333_abnormal_splenocyte_physiolog2.85382010
9MP0005083_abnormal_biliary_tract2.74853883
10MP0003880_abnormal_central_pattern2.53451965
11MP0009785_altered_susceptibility_to2.50399455
12MP0003252_abnormal_bile_duct2.46357429
13MP0001835_abnormal_antigen_presentation2.39704850
14MP0003646_muscle_fatigue2.36312658
15MP0005025_abnormal_response_to2.23598709
16MP0003436_decreased_susceptibility_to2.22268736
17MP0005000_abnormal_immune_tolerance2.16398902
18MP0003191_abnormal_cellular_cholesterol2.14847971
19MP0004043_abnormal_pH_regulation2.05781963
20MP0002420_abnormal_adaptive_immunity2.01820219
21MP0001819_abnormal_immune_cell1.99876531
22MP0002822_catalepsy1.95608987
23MP0001800_abnormal_humoral_immune1.95248187
24MP0002723_abnormal_immune_serum1.83402923
25MP0000685_abnormal_immune_system1.81953627
26MP0002398_abnormal_bone_marrow1.79122985
27MP0005451_abnormal_body_composition1.73304544
28MP0000703_abnormal_thymus_morphology1.68619575
29MP0000716_abnormal_immune_system1.67306955
30MP0002876_abnormal_thyroid_physiology1.56989614
31MP0002452_abnormal_antigen_presenting1.55728082
32MP0004185_abnormal_adipocyte_glucose1.53713450
33MP0002163_abnormal_gland_morphology1.52396398
34MP0001790_abnormal_immune_system1.44600258
35MP0005387_immune_system_phenotype1.44600258
36MP0002102_abnormal_ear_morphology1.44469276
37MP0002419_abnormal_innate_immunity1.40668158
38MP0005376_homeostasis/metabolism_phenot1.36857616
39MP0002166_altered_tumor_susceptibility1.35354864
40MP0001661_extended_life_span1.34642228
41MP0009379_abnormal_foot_pigmentation1.34515327
42MP0005253_abnormal_eye_physiology1.33722236
43MP0003866_abnormal_defecation1.32565914
44MP0002148_abnormal_hypersensitivity_rea1.31787942
45MP0002722_abnormal_immune_system1.29204200
46MP0005085_abnormal_gallbladder_physiolo1.27916396
47MP0006082_CNS_inflammation1.27507607
48MP0002429_abnormal_blood_cell1.27228994
49MP0005646_abnormal_pituitary_gland1.27010418
50MP0005379_endocrine/exocrine_gland_phen1.26146557
51MP0000689_abnormal_spleen_morphology1.25925434
52MP0004130_abnormal_muscle_cell1.22718805
53MP0005410_abnormal_fertilization1.20023299
54MP0004134_abnormal_chest_morphology1.19453505
55MP0002933_joint_inflammation1.18504347
56MP0001502_abnormal_circadian_rhythm1.15927996
57MP0000604_amyloidosis1.14420118
58MP0001765_abnormal_ion_homeostasis1.12324661
59MP0008057_abnormal_DNA_replication1.10351411
60MP0005266_abnormal_metabolism1.09490577
61MP0002138_abnormal_hepatobiliary_system1.07956761
62MP0002405_respiratory_system_inflammati1.06715510
63MP0002693_abnormal_pancreas_physiology1.06552793
64MP0005075_abnormal_melanosome_morpholog1.05875340
65MP0002006_tumorigenesis1.02067200
66MP0001346_abnormal_lacrimal_gland1.01100380
67MP0001986_abnormal_taste_sensitivity1.01045121
68MP0001853_heart_inflammation1.00421996
69MP0004381_abnormal_hair_follicle0.97955127
70MP0001501_abnormal_sleep_pattern0.95633927
71MP0001533_abnormal_skeleton_physiology0.93664818
72MP0003448_altered_tumor_morphology0.91975928
73MP0001905_abnormal_dopamine_level0.90899775
74MP0005636_abnormal_mineral_homeostasis0.89728665
75MP0001845_abnormal_inflammatory_respons0.89416233
76MP0004947_skin_inflammation0.88487633
77MP0003724_increased_susceptibility_to0.87987368
78MP0001873_stomach_inflammation0.87908150
79MP0010155_abnormal_intestine_physiology0.86766127
80MP0002837_dystrophic_cardiac_calcinosis0.84986614
81MP0005551_abnormal_eye_electrophysiolog0.84928378
82MP0005310_abnormal_salivary_gland0.84224763
83MP0008874_decreased_physiological_sensi0.83418202
84MP0002928_abnormal_bile_duct0.83316220
85MP0001919_abnormal_reproductive_system0.82787519
86MP0008469_abnormal_protein_level0.77711191
87MP0003633_abnormal_nervous_system0.76942681
88MP0002132_abnormal_respiratory_system0.76771556
89MP0003137_abnormal_impulse_conducting0.74768706
90MP0000639_abnormal_adrenal_gland0.74547273
91MP0009697_abnormal_copulation0.70561913
92MP0009764_decreased_sensitivity_to0.69556943
93MP0002127_abnormal_cardiovascular_syste0.69541036
94MP0003011_delayed_dark_adaptation0.66292185
95MP0003690_abnormal_glial_cell0.66252732
96MP0006054_spinal_hemorrhage0.64864608
97MP0001348_abnormal_lacrimal_gland0.63957694
98MP0004142_abnormal_muscle_tone0.61813529
99MP0010386_abnormal_urinary_bladder0.60616306
100MP0005377_hearing/vestibular/ear_phenot0.60021734

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.34156064
2Severe combined immunodeficiency (HP:0004430)5.80968391
3IgG deficiency (HP:0004315)5.78866006
4B lymphocytopenia (HP:0010976)5.76529198
5Autoimmune hemolytic anemia (HP:0001890)5.63722083
6Abnormality of B cell number (HP:0010975)5.58453165
7Bilateral sensorineural hearing impairment (HP:0008619)5.48291504
8IgM deficiency (HP:0002850)5.35999016
9T lymphocytopenia (HP:0005403)5.00205769
10Abnormality of T cell number (HP:0011839)4.90316036
11Thyroiditis (HP:0100646)4.66315872
12Abnormality of T cells (HP:0002843)4.60419226
13Combined immunodeficiency (HP:0005387)4.59901725
14Stomatitis (HP:0010280)4.54171775
15Absent rod-and cone-mediated responses on ERG (HP:0007688)4.53818491
16Tinnitus (HP:0000360)4.39873415
17Abnormality of dentin (HP:0010299)4.35256298
18Autoimmune thrombocytopenia (HP:0001973)4.29729828
19Increased IgM level (HP:0003496)4.13535466
20Abnormality of T cell physiology (HP:0011840)4.00502657
21Abnormal rod and cone electroretinograms (HP:0008323)3.83808525
22Hyperlipoproteinemia (HP:0010980)3.53954605
23Abnormality of eosinophils (HP:0001879)3.38383946
24Eosinophilia (HP:0001880)3.34741196
25Acute hepatic failure (HP:0006554)3.30392943
26Recurrent fungal infections (HP:0002841)3.12877174
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.10004497
28Increased IgE level (HP:0003212)3.01470760
29Lymphopenia (HP:0001888)2.96925085
30Encephalitis (HP:0002383)2.87073955
31Mesangial abnormality (HP:0001966)2.83077111
32Abnormality of cells of the lymphoid lineage (HP:0012140)2.82613385
33Hypergammaglobulinemia (HP:0010702)2.79882937
34Constricted visual fields (HP:0001133)2.79357216
353-Methylglutaconic aciduria (HP:0003535)2.79092805
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74592030
37Dyschromatopsia (HP:0007641)2.70315597
38Spontaneous hematomas (HP:0007420)2.67430507
39Recurrent bronchitis (HP:0002837)2.61588649
40Recurrent cutaneous fungal infections (HP:0011370)2.60045088
41Chronic mucocutaneous candidiasis (HP:0002728)2.60045088
42Leukocytosis (HP:0001974)2.59830580
43Granulocytopenia (HP:0001913)2.56325336
44Renal cortical cysts (HP:0000803)2.54590481
45Abnormality of the dental pulp (HP:0006479)2.51510928
46Bronchitis (HP:0012387)2.51046712
47Hypoproteinemia (HP:0003075)2.47280283
48Meningitis (HP:0001287)2.45278207
49Decreased circulating renin level (HP:0003351)2.44749746
50Limb dystonia (HP:0002451)2.42331866
51Congenital stationary night blindness (HP:0007642)2.40406138
52Panhypogammaglobulinemia (HP:0003139)2.37489887
53Hypoplasia of the thymus (HP:0000778)2.36676275
54Gaze-evoked nystagmus (HP:0000640)2.36359755
55Chronic bronchitis (HP:0004469)2.35712984
56Recurrent viral infections (HP:0004429)2.32591971
57Lymphoma (HP:0002665)2.30908068
58Radial bowing (HP:0002986)2.29983050
59Pustule (HP:0200039)2.29081537
60Myositis (HP:0100614)2.24926285
61Hyperactive renin-angiotensin system (HP:0000841)2.18583257
62Abnormality of macrophages (HP:0004311)2.18401010
63Vasculitis (HP:0002633)2.15472312
64Methylmalonic acidemia (HP:0002912)2.15365116
65Attenuation of retinal blood vessels (HP:0007843)2.10419956
66Recurrent skin infections (HP:0001581)2.09151381
67Pancytopenia (HP:0001876)2.08871625
68Recurrent bacterial skin infections (HP:0005406)2.07487295
69Recurrent abscess formation (HP:0002722)2.07046924
70Eczematoid dermatitis (HP:0000976)2.04602521
71Onycholysis (HP:0001806)2.00519027
72Acute necrotizing encephalopathy (HP:0006965)1.99789988
73Chronic obstructive pulmonary disease (HP:0006510)1.97186016
74Obstructive lung disease (HP:0006536)1.97186016
75Orchitis (HP:0100796)1.94937019
76Dysphonia (HP:0001618)1.93982087
77IgA deficiency (HP:0002720)1.93647111
78Bronchiectasis (HP:0002110)1.93455692
79Conical tooth (HP:0000698)1.88969407
80Cerebral edema (HP:0002181)1.86991405
81Optic neuritis (HP:0100653)1.86777431
82Retrobulbar optic neuritis (HP:0100654)1.86777431
83Tetraplegia (HP:0002445)1.85436432
84Cellular immunodeficiency (HP:0005374)1.84880269
85Recurrent otitis media (HP:0000403)1.81069392
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80738214
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.78385599
88Mediastinal lymphadenopathy (HP:0100721)1.77457657
89Ketosis (HP:0001946)1.76633907
90Severe visual impairment (HP:0001141)1.76148423
91Joint swelling (HP:0001386)1.72104032
92Urticaria (HP:0001025)1.70483859
93Neutropenia (HP:0001875)1.66465717
94Chest pain (HP:0100749)1.66227147
95Increased CSF protein (HP:0002922)1.65382958
96Acute encephalopathy (HP:0006846)1.64724490
97Squamous cell carcinoma (HP:0002860)1.63987844
98Sepsis (HP:0100806)1.62540587
99Progressive macrocephaly (HP:0004481)1.61969572
100Pancreatitis (HP:0001733)1.59164483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.16005314
2SIK34.11160944
3SCYL23.98664842
4TXK3.48208790
5TNK23.43084605
6KDR3.21724118
7ITK2.86281782
8SIK22.85399741
9SIK12.70096774
10CDK192.69176118
11ZAK2.53968058
12TESK12.50593058
13BCKDK2.50549954
14TEC2.41541311
15MAP3K112.14767241
16MAP3K122.11573173
17PASK2.10482470
18TLK11.99355066
19FES1.94115741
20BTK1.83012977
21LIMK11.77392971
22CSK1.66795361
23ERN11.56701212
24JAK31.53940696
25FGR1.39530310
26BLK1.38608351
27LCK1.36493824
28PRKCQ1.33868748
29MARK31.31283566
30MAP4K11.29000671
31ADRBK21.23527351
32PAK61.21745417
33IKBKE1.20030800
34MAPKAPK31.19598317
35SYK1.17883464
36NEK11.12556902
37MELK1.12116167
38TAOK21.10398326
39ZAP701.03068051
40WNK41.01500314
41PRPF4B0.99947186
42RPS6KA40.93048172
43PINK10.92775272
44LYN0.90908607
45WNK10.90489806
46MAP2K70.79304947
47GRK10.75531721
48VRK10.74430393
49KIT0.65178893
50RPS6KA50.61710842
51GRK60.60333605
52BMPR1B0.56774351
53PAK30.53116727
54FYN0.51675564
55HCK0.50354043
56FRK0.50304699
57TAOK10.49413296
58NLK0.47497445
59PIK3CG0.46154913
60MAPK110.45631875
61NUAK10.44953901
62RAF10.41887218
63TYK20.41196042
64JAK10.40028966
65TRPM70.39625077
66PRKAA10.38754840
67IGF1R0.38483292
68CAMKK10.37258750
69MYLK0.33703880
70TAOK30.33239134
71MARK20.33009792
72NEK60.31889041
73CAMK10.30738798
74IKBKB0.30661282
75OBSCN0.30485462
76CDK30.29532696
77INSR0.29267479
78BCR0.28886295
79RIPK40.27746053
80CSNK1A10.26860858
81INSRR0.26377032
82EGFR0.26348700
83MAPK150.25903071
84MST40.25411630
85PRKACA0.24660318
86CSF1R0.23604887
87IRAK30.23467201
88PIM10.23197043
89ABL10.23016869
90ERBB30.22520619
91PKN10.21409205
92WNK30.20857031
93KSR20.19190341
94MAPKAPK20.19143421
95JAK20.18927401
96PRKG20.18762981
97PRKCA0.18426150
98AURKA0.17792381
99DAPK10.17468930
100ADRBK10.16982252

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.93710550
2Graft-versus-host disease_Homo sapiens_hsa053323.80192666
3T cell receptor signaling pathway_Homo sapiens_hsa046603.52693963
4Antigen processing and presentation_Homo sapiens_hsa046123.43833379
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.31613961
6Proteasome_Homo sapiens_hsa030502.66057214
7Hematopoietic cell lineage_Homo sapiens_hsa046402.42531528
8Phototransduction_Homo sapiens_hsa047442.31928954
9Caffeine metabolism_Homo sapiens_hsa002322.20830711
10Allograft rejection_Homo sapiens_hsa053302.12305516
11Autoimmune thyroid disease_Homo sapiens_hsa053202.01473444
12Folate biosynthesis_Homo sapiens_hsa007901.94339558
13Measles_Homo sapiens_hsa051621.93328060
14Oxidative phosphorylation_Homo sapiens_hsa001901.91240682
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.85877799
16One carbon pool by folate_Homo sapiens_hsa006701.79717969
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.61890197
18Ribosome_Homo sapiens_hsa030101.61325921
19Malaria_Homo sapiens_hsa051441.51978206
20Type I diabetes mellitus_Homo sapiens_hsa049401.51486045
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45994277
22Parkinsons disease_Homo sapiens_hsa050121.44050492
23Olfactory transduction_Homo sapiens_hsa047401.43227882
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33253404
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29089353
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25673269
27Retinol metabolism_Homo sapiens_hsa008301.18439559
28Alzheimers disease_Homo sapiens_hsa050101.17035698
29Shigellosis_Homo sapiens_hsa051311.12575723
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10458365
31Morphine addiction_Homo sapiens_hsa050321.05091298
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03428939
33ABC transporters_Homo sapiens_hsa020101.01108691
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99243871
35Chemokine signaling pathway_Homo sapiens_hsa040620.97935431
36Linoleic acid metabolism_Homo sapiens_hsa005910.96313767
37Viral myocarditis_Homo sapiens_hsa054160.95062029
38Systemic lupus erythematosus_Homo sapiens_hsa053220.93391264
39Herpes simplex infection_Homo sapiens_hsa051680.89599212
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86151040
41Osteoclast differentiation_Homo sapiens_hsa043800.85358498
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85144648
43Propanoate metabolism_Homo sapiens_hsa006400.84045734
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83395407
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.81922114
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80845656
47Peroxisome_Homo sapiens_hsa041460.79256741
48Taste transduction_Homo sapiens_hsa047420.78119710
49Rheumatoid arthritis_Homo sapiens_hsa053230.77935527
50Tryptophan metabolism_Homo sapiens_hsa003800.76845876
51TNF signaling pathway_Homo sapiens_hsa046680.74574626
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.63756027
53Huntingtons disease_Homo sapiens_hsa050160.63732769
54Cardiac muscle contraction_Homo sapiens_hsa042600.62009576
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60028594
56Asthma_Homo sapiens_hsa053100.58189998
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54495855
58Alcoholism_Homo sapiens_hsa050340.54428197
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54264269
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.53419874
61Leishmaniasis_Homo sapiens_hsa051400.50748306
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.49674641
63Apoptosis_Homo sapiens_hsa042100.48944081
64GABAergic synapse_Homo sapiens_hsa047270.48165322
65Circadian entrainment_Homo sapiens_hsa047130.47198904
66HTLV-I infection_Homo sapiens_hsa051660.46028187
67Legionellosis_Homo sapiens_hsa051340.45630962
68Endocytosis_Homo sapiens_hsa041440.42464552
69Salmonella infection_Homo sapiens_hsa051320.41088896
70African trypanosomiasis_Homo sapiens_hsa051430.40818111
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.39476887
72Staphylococcus aureus infection_Homo sapiens_hsa051500.37238110
73Mineral absorption_Homo sapiens_hsa049780.36774144
74Cholinergic synapse_Homo sapiens_hsa047250.35818885
75Butanoate metabolism_Homo sapiens_hsa006500.34707855
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34677670
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34260738
78Calcium signaling pathway_Homo sapiens_hsa040200.32235188
79Renin secretion_Homo sapiens_hsa049240.32022303
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32006069
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30739126
82Small cell lung cancer_Homo sapiens_hsa052220.29810711
83Viral carcinogenesis_Homo sapiens_hsa052030.29414718
84Fanconi anemia pathway_Homo sapiens_hsa034600.27852724
85Tuberculosis_Homo sapiens_hsa051520.27470214
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27435295
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26385236
88Nitrogen metabolism_Homo sapiens_hsa009100.26171376
89Ras signaling pathway_Homo sapiens_hsa040140.25858451
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25439919
91Chemical carcinogenesis_Homo sapiens_hsa052040.24609014
92Base excision repair_Homo sapiens_hsa034100.23918462
93Regulation of autophagy_Homo sapiens_hsa041400.22892179
94Serotonergic synapse_Homo sapiens_hsa047260.21738843
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.20305252
96B cell receptor signaling pathway_Homo sapiens_hsa046620.19298660
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.19219640
98cAMP signaling pathway_Homo sapiens_hsa040240.17743093
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17073887
100Ether lipid metabolism_Homo sapiens_hsa005650.16980269

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