TRAJ20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)7.63658379
2cytidine metabolic process (GO:0046087)7.43835094
3cytidine catabolic process (GO:0006216)7.43835094
4cytidine deamination (GO:0009972)7.43835094
5negative T cell selection (GO:0043383)7.34752231
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.10819048
7positive regulation of gamma-delta T cell activation (GO:0046645)6.89314700
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.84612954
9pyrimidine ribonucleoside catabolic process (GO:0046133)6.67625302
10positive T cell selection (GO:0043368)6.27688631
11regulation of B cell receptor signaling pathway (GO:0050855)6.13006667
12regulation of gamma-delta T cell differentiation (GO:0045586)5.87656611
13DNA deamination (GO:0045006)5.79957264
14negative thymic T cell selection (GO:0045060)5.75842371
15positive regulation of interleukin-8 secretion (GO:2000484)5.64070587
16positive thymic T cell selection (GO:0045059)5.34031479
17regulation of gamma-delta T cell activation (GO:0046643)5.07117263
18cellular response to interleukin-15 (GO:0071350)4.92577490
19T cell receptor signaling pathway (GO:0050852)4.82115280
20regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.81690389
21regulation of T cell receptor signaling pathway (GO:0050856)4.75619612
22interferon-gamma production (GO:0032609)4.74060057
23regulation of interleukin-12 biosynthetic process (GO:0045075)4.63044262
24lymphocyte chemotaxis (GO:0048247)4.60522590
25positive regulation of alpha-beta T cell proliferation (GO:0046641)4.59759667
26regulation of regulatory T cell differentiation (GO:0045589)4.59173493
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.49572794
28positive regulation of calcium-mediated signaling (GO:0050850)4.45410212
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.42193792
30thymic T cell selection (GO:0045061)4.39461509
31chemokine-mediated signaling pathway (GO:0070098)4.39294714
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38067348
33mast cell activation (GO:0045576)4.37831863
34Arp2/3 complex-mediated actin nucleation (GO:0034314)4.34522382
35response to interleukin-15 (GO:0070672)4.32061763
36negative regulation of T cell apoptotic process (GO:0070233)4.31336420
37positive regulation of monocyte chemotaxis (GO:0090026)4.30088015
38T cell selection (GO:0045058)4.27192153
39lymphocyte migration (GO:0072676)4.22354966
40antigen receptor-mediated signaling pathway (GO:0050851)4.21689294
41positive regulation of granulocyte differentiation (GO:0030854)4.18833102
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.11485226
43leukocyte aggregation (GO:0070486)4.11380432
44positive regulation of B cell differentiation (GO:0045579)4.10231431
45regulation of lymphocyte chemotaxis (GO:1901623)4.09292850
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05695510
47negative regulation of cell killing (GO:0031342)4.05695510
48regulation of interleukin-8 secretion (GO:2000482)4.01649132
49regulation of B cell differentiation (GO:0045577)4.01117252
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.99015934
51regulation of natural killer cell mediated immunity (GO:0002715)3.99015934
52regulation of alpha-beta T cell proliferation (GO:0046640)3.96904578
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.93398438
54negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.93207834
55regulation of defense response to virus by virus (GO:0050690)3.82939973
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81187611
57T cell costimulation (GO:0031295)3.76502906
58lymphocyte costimulation (GO:0031294)3.71697934
59actin nucleation (GO:0045010)3.68642264
60positive regulation of lymphocyte migration (GO:2000403)3.58670549
61negative regulation by host of viral transcription (GO:0043922)3.58620419
62positive regulation of cell killing (GO:0031343)3.51298411
63regulation of T cell mediated cytotoxicity (GO:0001914)3.50681817
64eosinophil chemotaxis (GO:0048245)3.46544883
65negative regulation of execution phase of apoptosis (GO:1900118)3.46022461
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46017066
67regulation of cell killing (GO:0031341)3.44447179
68cellular defense response (GO:0006968)3.39253229
69negative regulation of T cell receptor signaling pathway (GO:0050860)3.37711654
70negative regulation of viral genome replication (GO:0045071)3.36132328
71regulation of T cell chemotaxis (GO:0010819)3.35425506
72positive regulation of T cell chemotaxis (GO:0010820)3.35425506
73T cell differentiation (GO:0030217)3.35044128
74pyrimidine nucleoside catabolic process (GO:0046135)3.33812835
75positive regulation of humoral immune response (GO:0002922)3.33123985
76negative regulation of viral transcription (GO:0032897)3.29456549
77lymph node development (GO:0048535)3.28563577
78regulation of T cell apoptotic process (GO:0070232)3.28531750
79positive regulation of T cell mediated cytotoxicity (GO:0001916)3.28383849
80regulation of calcium-mediated signaling (GO:0050848)3.27447884
81dendritic cell chemotaxis (GO:0002407)3.20786199
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20572758
83viral genome replication (GO:0019079)3.16464982
84regulation of activation of Janus kinase activity (GO:0010533)3.15373285
85eosinophil migration (GO:0072677)3.13550859
86positive regulation of uterine smooth muscle contraction (GO:0070474)3.08918103
87B cell receptor signaling pathway (GO:0050853)3.08591449
88negative regulation of bone resorption (GO:0045779)3.07239783
89ncRNA 3-end processing (GO:0043628)3.05229612
90antigen processing and presentation of endogenous antigen (GO:0019883)3.03594322
91negative regulation of glycogen biosynthetic process (GO:0045719)3.03001592
92cytolysis (GO:0019835)3.02682302
93positive regulation of T cell differentiation in thymus (GO:0033089)3.02421788
94T cell mediated immunity (GO:0002456)3.01599535
95regulation of isotype switching to IgG isotypes (GO:0048302)2.99413484
96mast cell activation involved in immune response (GO:0002279)2.99132531
97mast cell degranulation (GO:0043303)2.99132531
98negative regulation of lymphocyte apoptotic process (GO:0070229)2.98701427
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94390082
100T cell activation (GO:0042110)2.93135087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.02768885
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.27772147
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.12549016
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.64528790
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.50993350
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.26155197
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64712122
8RUNX_20019798_ChIP-Seq_JUKART_Human3.58915976
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.45998867
10MYB_26560356_Chip-Seq_TH2_Human3.45590031
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44073854
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96617261
13GATA1_22025678_ChIP-Seq_K562_Human2.89920580
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77703067
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76764231
16GATA3_27048872_Chip-Seq_THYMUS_Human2.71954914
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57193285
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56999240
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49376828
20MYB_26560356_Chip-Seq_TH1_Human2.48147226
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30225751
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27551382
23UTX_26944678_Chip-Seq_JUKART_Human2.22518656
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.15320031
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90357242
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89583425
27GATA3_26560356_Chip-Seq_TH2_Human1.89442848
28MAF_26560356_Chip-Seq_TH2_Human1.87790688
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.81408892
30MAF_26560356_Chip-Seq_TH1_Human1.76971200
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.72678874
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71477419
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56543176
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.52314092
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52295070
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49335794
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48790291
38SPI1_23547873_ChIP-Seq_NB4_Human1.43447656
39TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.38993797
40CIITA_25753668_ChIP-Seq_RAJI_Human1.35820441
41VDR_23849224_ChIP-Seq_CD4+_Human1.28172178
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21125986
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19460737
44RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17830116
45BCL6_27268052_Chip-Seq_Bcells_Human1.15165116
46P300_27268052_Chip-Seq_Bcells_Human1.13296157
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13086449
48SCL_19346495_ChIP-Seq_HPC-7_Human1.12927482
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11301480
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10403698
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07779098
52TAF15_26573619_Chip-Seq_HEK293_Human1.02487525
53FOXP3_21729870_ChIP-Seq_TREG_Human1.02375007
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.02148606
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01187490
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01164358
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00853510
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00430632
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00399838
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99699536
61FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98360897
62FOXA1_25329375_ChIP-Seq_VCAP_Human0.98360897
63STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96408009
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93699306
65FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91784828
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91494535
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90423499
68GATA6_21074721_ChIP-Seq_CACO-2_Human0.89981420
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88782046
70HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88075833
71SPI1_23127762_ChIP-Seq_K562_Human0.87618827
72GATA3_26560356_Chip-Seq_TH1_Human0.87069490
73HTT_18923047_ChIP-ChIP_STHdh_Human0.83302518
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82821827
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82806310
76NANOG_20526341_ChIP-Seq_ESCs_Human0.81441837
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81426030
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81344077
79NCOR_22424771_ChIP-Seq_293T_Human0.79971418
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.79456369
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79084310
82TP53_22573176_ChIP-Seq_HFKS_Human0.78000411
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77890287
84SMRT_27268052_Chip-Seq_Bcells_Human0.77509943
85VDR_24787735_ChIP-Seq_THP-1_Human0.75654662
86RBPJ_21746931_ChIP-Seq_IB4_Human0.75050255
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74359434
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73174323
89AR_20517297_ChIP-Seq_VCAP_Human0.71482332
90CEBPB_22108803_ChIP-Seq_LS180_Human0.70570024
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70234802
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.69487088
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.68352909
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.66774032
95CBX2_22325352_ChIP-Seq_293T-Rex_Human0.66728928
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66469801
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65897484
98CTCF_20526341_ChIP-Seq_ESCs_Human0.65710408
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65512436
100BCOR_27268052_Chip-Seq_Bcells_Human0.65238282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.14146279
2MP0003763_abnormal_thymus_physiology5.17876234
3MP0009785_altered_susceptibility_to4.11642101
4MP0003866_abnormal_defecation3.29485884
5MP0009333_abnormal_splenocyte_physiolog3.10569101
6MP0005000_abnormal_immune_tolerance2.94411715
7MP0001800_abnormal_humoral_immune2.94098535
8MP0001835_abnormal_antigen_presentation2.89528812
9MP0005025_abnormal_response_to2.71486019
10MP0006082_CNS_inflammation2.69883211
11MP0003646_muscle_fatigue2.64477962
12MP0002723_abnormal_immune_serum2.60255255
13MP0002420_abnormal_adaptive_immunity2.57980586
14MP0004381_abnormal_hair_follicle2.53676206
15MP0002148_abnormal_hypersensitivity_rea2.52158010
16MP0001819_abnormal_immune_cell2.50649869
17MP0000703_abnormal_thymus_morphology2.28663452
18MP0003436_decreased_susceptibility_to2.25276910
19MP0003878_abnormal_ear_physiology2.19462307
20MP0005377_hearing/vestibular/ear_phenot2.19462307
21MP0005075_abnormal_melanosome_morpholog2.16848022
22MP0002452_abnormal_antigen_presenting2.12071546
23MP0003045_fibrosis2.08135487
24MP0000685_abnormal_immune_system2.06185110
25MP0010155_abnormal_intestine_physiology2.01019717
26MP0002405_respiratory_system_inflammati2.00930733
27MP0002398_abnormal_bone_marrow1.97431645
28MP0000716_abnormal_immune_system1.93771542
29MP0003724_increased_susceptibility_to1.91535371
30MP0003787_abnormal_imprinting1.84601849
31MP0000689_abnormal_spleen_morphology1.81332886
32MP0002166_altered_tumor_susceptibility1.79717090
33MP0002722_abnormal_immune_system1.79463877
34MP0002419_abnormal_innate_immunity1.78382829
35MP0001790_abnormal_immune_system1.74363767
36MP0005387_immune_system_phenotype1.74363767
37MP0001845_abnormal_inflammatory_respons1.61577848
38MP0003172_abnormal_lysosome_physiology1.55229982
39MP0005166_decreased_susceptibility_to1.51629603
40MP0005645_abnormal_hypothalamus_physiol1.50423461
41MP0002102_abnormal_ear_morphology1.49299764
42MP0005464_abnormal_platelet_physiology1.47337008
43MP0003448_altered_tumor_morphology1.44845826
44MP0009764_decreased_sensitivity_to1.42053049
45MP0002429_abnormal_blood_cell1.40814398
46MP0004145_abnormal_muscle_electrophysio1.35475440
47MP0002006_tumorigenesis1.26036427
48MP0002693_abnormal_pancreas_physiology1.21625837
49MP0008469_abnormal_protein_level1.20462875
50MP0002933_joint_inflammation1.18228402
51MP0000569_abnormal_digit_pigmentation1.16551324
52MP0009763_increased_sensitivity_to1.13869440
53MP0002163_abnormal_gland_morphology1.13452712
54MP0008260_abnormal_autophagy1.06595451
55MP0004947_skin_inflammation1.02996737
56MP0001919_abnormal_reproductive_system1.01647163
57MP0003195_calcinosis0.98004866
58MP0001542_abnormal_bone_strength0.97790202
59MP0001533_abnormal_skeleton_physiology0.90072758
60MP0005360_urolithiasis0.88250294
61MP0009643_abnormal_urine_homeostasis0.87051591
62MP0009765_abnormal_xenobiotic_induced0.85445738
63MP0004883_abnormal_blood_vessel0.83653460
64MP0000015_abnormal_ear_pigmentation0.83241298
65MP0003690_abnormal_glial_cell0.82664046
66MP0002136_abnormal_kidney_physiology0.80358504
67MP0001764_abnormal_homeostasis0.78257874
68MP0002019_abnormal_tumor_incidence0.76234869
69MP0000372_irregular_coat_pigmentation0.72925023
70MP0001984_abnormal_olfaction0.72903156
71MP0005389_reproductive_system_phenotype0.72830274
72MP0002095_abnormal_skin_pigmentation0.72239019
73MP0003075_altered_response_to0.71728444
74MP0000858_altered_metastatic_potential0.70266089
75MP0003880_abnormal_central_pattern0.69609190
76MP0002277_abnormal_respiratory_mucosa0.66726701
77MP0001485_abnormal_pinna_reflex0.66089207
78MP0002168_other_aberrant_phenotype0.64057777
79MP0000490_abnormal_crypts_of0.63819474
80MP0000604_amyloidosis0.63716831
81MP0001765_abnormal_ion_homeostasis0.63491637
82MP0003011_delayed_dark_adaptation0.63207050
83MP0005310_abnormal_salivary_gland0.62639145
84MP0005551_abnormal_eye_electrophysiolog0.58872571
85MP0000920_abnormal_myelination0.58247245
86MP0005058_abnormal_lysosome_morphology0.57135747
87MP0002998_abnormal_bone_remodeling0.57119525
88MP0003137_abnormal_impulse_conducting0.56441870
89MP0000477_abnormal_intestine_morphology0.56350004
90MP0003786_premature_aging0.55420525
91MP0008873_increased_physiological_sensi0.53930518
92MP0001243_abnormal_dermal_layer0.53795631
93MP0005332_abnormal_amino_acid0.51666332
94MP0001905_abnormal_dopamine_level0.51630119
95MP0005266_abnormal_metabolism0.50829849
96MP0010386_abnormal_urinary_bladder0.49436110
97MP0003693_abnormal_embryo_hatching0.49302581
98MP0002876_abnormal_thyroid_physiology0.49148827
99MP0005379_endocrine/exocrine_gland_phen0.47364071
100MP0002083_premature_death0.46264973

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.90342416
2Abnormality of T cell number (HP:0011839)8.19444422
3Severe combined immunodeficiency (HP:0004430)6.91576805
4Abnormality of T cells (HP:0002843)6.27212459
5Combined immunodeficiency (HP:0005387)5.65597063
6Aplastic anemia (HP:0001915)5.59444162
7Stomatitis (HP:0010280)5.05332714
8Autoimmune hemolytic anemia (HP:0001890)5.05155514
9IgG deficiency (HP:0004315)5.02108347
10Thyroiditis (HP:0100646)4.52586019
11Chronic diarrhea (HP:0002028)4.35244818
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.17480027
13Gastrointestinal infarctions (HP:0005244)4.17449719
14Panhypogammaglobulinemia (HP:0003139)4.08335045
15Recurrent cutaneous fungal infections (HP:0011370)3.97575950
16Chronic mucocutaneous candidiasis (HP:0002728)3.97575950
17Recurrent bronchitis (HP:0002837)3.97241127
18Abnormality of T cell physiology (HP:0011840)3.92857643
19IgM deficiency (HP:0002850)3.77490182
20Abnormality of eosinophils (HP:0001879)3.76517877
21Hypoproteinemia (HP:0003075)3.65915292
22Autoimmune thrombocytopenia (HP:0001973)3.52752681
23Elevated erythrocyte sedimentation rate (HP:0003565)3.49641401
24Hypoplasia of the thymus (HP:0000778)3.39361542
25Abnormality of macrophages (HP:0004311)3.36987682
26Eczematoid dermatitis (HP:0000976)3.34349981
27Recurrent fungal infections (HP:0002841)3.34184209
28Recurrent viral infections (HP:0004429)3.16957474
29Lymphopenia (HP:0001888)3.10341201
30Leukocytosis (HP:0001974)2.97866247
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.95974940
32Abnormality of B cell number (HP:0010975)2.91707039
33Agammaglobulinemia (HP:0004432)2.90976264
34Recurrent skin infections (HP:0001581)2.89460578
35B lymphocytopenia (HP:0010976)2.75956278
36Congenital stationary night blindness (HP:0007642)2.74492747
37Eosinophilia (HP:0001880)2.69794817
38Meningitis (HP:0001287)2.69731441
39Vasculitis (HP:0002633)2.69239221
40Lymphoma (HP:0002665)2.68988501
41Obstructive lung disease (HP:0006536)2.65430255
42Chronic obstructive pulmonary disease (HP:0006510)2.65430255
43Recurrent bacterial skin infections (HP:0005406)2.60638050
44Pigmentary retinal degeneration (HP:0001146)2.60417679
45Bronchitis (HP:0012387)2.54959264
46Acute hepatic failure (HP:0006554)2.51463885
47Abnormality of the prostate (HP:0008775)2.49686034
48Encephalitis (HP:0002383)2.36603739
49Mediastinal lymphadenopathy (HP:0100721)2.35654386
50Joint swelling (HP:0001386)2.35402375
51Hemiplegia (HP:0002301)2.34242750
52Tetany (HP:0001281)2.31166047
53Recurrent abscess formation (HP:0002722)2.22148273
54Gangrene (HP:0100758)2.21460356
55Hyperlipoproteinemia (HP:0010980)2.17352713
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15950087
57Carpal bone hypoplasia (HP:0001498)2.14907378
58Increased circulating renin level (HP:0000848)2.14536615
59Abnormal albumin level (HP:0012116)2.13607261
60Hypoalbuminemia (HP:0003073)2.13607261
61Chest pain (HP:0100749)2.12239399
62Mitochondrial inheritance (HP:0001427)2.11752974
63Diplopia (HP:0000651)2.10203364
64Abnormality of binocular vision (HP:0011514)2.10203364
65Genetic anticipation (HP:0003743)2.09990208
66Abnormality of the alveolar ridges (HP:0006477)2.09415077
67Amaurosis fugax (HP:0100576)2.07650349
68Stomach cancer (HP:0012126)2.07147765
69Granulocytopenia (HP:0001913)2.05874035
70Hemoptysis (HP:0002105)1.98765645
71Pulmonary infiltrates (HP:0002113)1.96884109
72Premature graying of hair (HP:0002216)1.90817295
73Retrobulbar optic neuritis (HP:0100654)1.89381514
74Optic neuritis (HP:0100653)1.89381514
75Ureteral stenosis (HP:0000071)1.89028626
76Hepatocellular necrosis (HP:0001404)1.87927403
77Recurrent otitis media (HP:0000403)1.86994057
78Pancytopenia (HP:0001876)1.84891149
79Vacuolated lymphocytes (HP:0001922)1.84745427
80Anorexia (HP:0002039)1.82897227
81Renal cortical cysts (HP:0000803)1.81483069
82Pustule (HP:0200039)1.78822688
83Bronchiectasis (HP:0002110)1.75546546
84Ureteral obstruction (HP:0006000)1.73736497
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.73495883
86Aplasia/Hypoplasia of the thymus (HP:0010515)1.73357758
87Centrally nucleated skeletal muscle fibers (HP:0003687)1.69988030
88Recurrent sinusitis (HP:0011108)1.69673467
89Hypomagnesemia (HP:0002917)1.68050905
90Increased IgM level (HP:0003496)1.66448275
91Abolished electroretinogram (ERG) (HP:0000550)1.66109597
92Acute necrotizing encephalopathy (HP:0006965)1.65680161
93Pulmonary embolism (HP:0002204)1.63691939
94Arterial thrombosis (HP:0004420)1.63361500
95Hepatic necrosis (HP:0002605)1.62196673
96Reduced antithrombin III activity (HP:0001976)1.62149435
97Severe global developmental delay (HP:0011344)1.61476150
98Abnormal drinking behavior (HP:0030082)1.60996696
99Polydipsia (HP:0001959)1.60996696
100Cerebral hypomyelination (HP:0006808)1.58940683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.64434903
2TESK26.05853767
3KDR3.80806516
4MAP4K13.69380138
5ITK3.34549341
6PASK3.20934259
7MAP3K122.47708652
8ZAP702.37771351
9TESK12.30788775
10FES2.26401921
11TEC2.18460255
12CSK1.87762240
13SYK1.86720125
14TAOK31.83415577
15MAP3K111.79472177
16BTK1.72186280
17SCYL21.63735017
18EIF2AK31.56482527
19JAK31.56011118
20BCKDK1.54006882
21MST41.50267850
22LIMK11.47716439
23RPS6KA41.45208853
24GRK61.42766916
25CAMKK11.42362722
26NLK1.37581468
27LCK1.34994671
28MAPKAPK31.31580169
29PRKCQ1.30703896
30LYN1.27477922
31ADRBK21.19923631
32RIPK41.07714843
33HCK1.03293483
34TNK21.02356260
35CLK10.95293802
36IRAK40.94924757
37FRK0.82478464
38CSF1R0.78941168
39FYN0.77367678
40NUAK10.76127523
41IKBKE0.73881636
42BMX0.67985166
43ZAK0.65249733
44BUB10.65119583
45RPS6KA50.64907000
46IGF1R0.62051038
47PRKCH0.61243421
48NEK60.60498770
49GRK70.60119036
50TYRO30.59380544
51PIK3CG0.54160962
52SGK2230.54003199
53SGK4940.54003199
54MAP3K100.53711003
55TAOK20.52884383
56JAK10.49789310
57INSR0.47180787
58PIM10.46624209
59GRK10.42835629
60STK380.42776770
61MYLK0.41361861
62DAPK10.39876725
63KIT0.38766356
64CAMK10.37684976
65SGK20.36701259
66PDK10.36232159
67OBSCN0.36206742
68PTK2B0.35065450
69LRRK20.34276282
70BLK0.32719058
71PIM20.30887728
72CAMKK20.30562449
73PRKCA0.30098691
74VRK20.29331737
75PLK40.29052303
76CDK30.29014064
77INSRR0.27499932
78GRK50.26849045
79PRKCB0.26780559
80PIK3CA0.25879499
81SGK10.25460331
82ABL10.23954768
83PRKCD0.23605350
84MAP3K30.23014942
85MELK0.22887184
86MAPKAPK20.22846273
87MAP2K60.22015618
88MAPK130.21180892
89PRKD20.19418637
90TIE10.19318300
91ADRBK10.18539341
92TAOK10.18464616
93PRKACA0.18157613
94IKBKB0.17601252
95PRKD10.17355677
96MAP3K50.16524424
97STK390.16508839
98MAP2K30.15451491
99FGR0.15442871
100PDGFRB0.15379428

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053408.00830886
2T cell receptor signaling pathway_Homo sapiens_hsa046603.82356934
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.72985958
4Antigen processing and presentation_Homo sapiens_hsa046123.21595514
5Hematopoietic cell lineage_Homo sapiens_hsa046403.01743107
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00484947
7Graft-versus-host disease_Homo sapiens_hsa053322.86046927
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.43206019
9Allograft rejection_Homo sapiens_hsa053302.41736834
10Autoimmune thyroid disease_Homo sapiens_hsa053202.38500226
11Type I diabetes mellitus_Homo sapiens_hsa049401.97124209
12RNA polymerase_Homo sapiens_hsa030201.94283728
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.87129818
14Proteasome_Homo sapiens_hsa030501.84573697
15Measles_Homo sapiens_hsa051621.72509523
16Malaria_Homo sapiens_hsa051441.66421946
17Salmonella infection_Homo sapiens_hsa051321.62764574
18Rheumatoid arthritis_Homo sapiens_hsa053231.57162173
19Chemokine signaling pathway_Homo sapiens_hsa040621.51668080
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43715970
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42092585
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36981696
23Oxidative phosphorylation_Homo sapiens_hsa001901.21726827
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20587062
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13518829
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12049350
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06040928
28Viral myocarditis_Homo sapiens_hsa054161.02959862
29Phototransduction_Homo sapiens_hsa047440.99658297
30Intestinal immune network for IgA production_Homo sapiens_hsa046720.99500201
31Parkinsons disease_Homo sapiens_hsa050120.98559005
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97400145
33Sulfur metabolism_Homo sapiens_hsa009200.97159956
34Protein export_Homo sapiens_hsa030600.93761068
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92205069
36Systemic lupus erythematosus_Homo sapiens_hsa053220.83656973
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81328666
38B cell receptor signaling pathway_Homo sapiens_hsa046620.79064514
39Osteoclast differentiation_Homo sapiens_hsa043800.75192262
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74414836
41TNF signaling pathway_Homo sapiens_hsa046680.73220173
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72473370
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71930135
44Alzheimers disease_Homo sapiens_hsa050100.71278365
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.70983491
46Shigellosis_Homo sapiens_hsa051310.70827481
47Staphylococcus aureus infection_Homo sapiens_hsa051500.70489493
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69077168
49Nitrogen metabolism_Homo sapiens_hsa009100.68939991
50Herpes simplex infection_Homo sapiens_hsa051680.68232162
51Epstein-Barr virus infection_Homo sapiens_hsa051690.66277170
52Retinol metabolism_Homo sapiens_hsa008300.65051137
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62030406
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.60482717
55Olfactory transduction_Homo sapiens_hsa047400.59573611
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58711568
57Caffeine metabolism_Homo sapiens_hsa002320.58467942
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56949926
59Tuberculosis_Homo sapiens_hsa051520.49843587
60HTLV-I infection_Homo sapiens_hsa051660.49564020
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45688247
62Purine metabolism_Homo sapiens_hsa002300.44924199
63Legionellosis_Homo sapiens_hsa051340.44700516
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44636701
65Ribosome_Homo sapiens_hsa030100.44503806
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.44443133
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43774132
68Platelet activation_Homo sapiens_hsa046110.42144664
69Huntingtons disease_Homo sapiens_hsa050160.41386574
70Cardiac muscle contraction_Homo sapiens_hsa042600.41249617
71Endocytosis_Homo sapiens_hsa041440.41045242
72Apoptosis_Homo sapiens_hsa042100.40916622
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38909359
74Pyrimidine metabolism_Homo sapiens_hsa002400.37233560
75Homologous recombination_Homo sapiens_hsa034400.36432411
76Calcium signaling pathway_Homo sapiens_hsa040200.36111320
77Collecting duct acid secretion_Homo sapiens_hsa049660.35829992
78Leishmaniasis_Homo sapiens_hsa051400.34524141
79Influenza A_Homo sapiens_hsa051640.33754150
80Prion diseases_Homo sapiens_hsa050200.30928924
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29316998
82Pertussis_Homo sapiens_hsa051330.29174564
83Amphetamine addiction_Homo sapiens_hsa050310.28451536
84Phagosome_Homo sapiens_hsa041450.23661079
85Morphine addiction_Homo sapiens_hsa050320.23455319
86Asthma_Homo sapiens_hsa053100.22745881
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22384515
88Alcoholism_Homo sapiens_hsa050340.22380830
89Mineral absorption_Homo sapiens_hsa049780.22050940
90Ras signaling pathway_Homo sapiens_hsa040140.21583501
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.21472419
92Tyrosine metabolism_Homo sapiens_hsa003500.21327141
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21033749
94Regulation of autophagy_Homo sapiens_hsa041400.20048454
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19417727
96Pancreatic secretion_Homo sapiens_hsa049720.19353693
97Peroxisome_Homo sapiens_hsa041460.19295954
98Viral carcinogenesis_Homo sapiens_hsa052030.18302216
99Butanoate metabolism_Homo sapiens_hsa006500.17148296
100Fatty acid biosynthesis_Homo sapiens_hsa000610.17112643

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