TRAJ23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)7.24964002
2positive T cell selection (GO:0043368)7.12366766
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.33978683
4sphingomyelin metabolic process (GO:0006684)6.09158320
5positive thymic T cell selection (GO:0045059)6.08527949
6eosinophil chemotaxis (GO:0048245)5.99763569
7negative T cell selection (GO:0043383)5.95773099
8regulation of antigen receptor-mediated signaling pathway (GO:0050854)5.87245211
9positive regulation of tolerance induction (GO:0002645)5.76200305
10negative regulation of T cell receptor signaling pathway (GO:0050860)5.53133993
11cellular response to interleukin-15 (GO:0071350)5.47034573
12eosinophil migration (GO:0072677)5.39512879
13negative regulation by host of viral transcription (GO:0043922)5.35565486
14regulation of T cell tolerance induction (GO:0002664)5.34355704
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.13543891
16negative thymic T cell selection (GO:0045060)5.06642292
17cytidine deamination (GO:0009972)4.93691884
18cytidine metabolic process (GO:0046087)4.93691884
19cytidine catabolic process (GO:0006216)4.93691884
20macrophage chemotaxis (GO:0048246)4.91285380
21thymic T cell selection (GO:0045061)4.83794823
22T cell selection (GO:0045058)4.81883945
23regulation of lymphocyte chemotaxis (GO:1901623)4.71758110
24auditory receptor cell differentiation (GO:0042491)4.70403779
25regulation of T cell receptor signaling pathway (GO:0050856)4.69958516
26regulation of vitamin D biosynthetic process (GO:0060556)4.66689729
27positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.52247819
28regulation of tolerance induction (GO:0002643)4.48239494
29negative regulation of monooxygenase activity (GO:0032769)4.45516044
30pyrimidine ribonucleoside catabolic process (GO:0046133)4.38715583
31regulation of alpha-beta T cell proliferation (GO:0046640)4.34568850
32regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.29517027
33response to interleukin-15 (GO:0070672)4.28075221
34negative regulation of T cell differentiation in thymus (GO:0033085)4.27849638
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18178427
36DNA deamination (GO:0045006)4.13422740
37positive regulation of gamma-delta T cell activation (GO:0046645)4.10417224
38positive regulation of calcium-mediated signaling (GO:0050850)4.05480595
39positive regulation of macrophage differentiation (GO:0045651)4.00195005
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95174782
41negative regulation of cell fate specification (GO:0009996)3.93993387
42T cell receptor signaling pathway (GO:0050852)3.90974099
43T cell migration (GO:0072678)3.84005042
44positive regulation of T cell apoptotic process (GO:0070234)3.82547149
45positive regulation of fatty acid oxidation (GO:0046321)3.80710916
46regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.80524357
47histone H2A acetylation (GO:0043968)3.75571292
48sulfation (GO:0051923)3.71882247
49negative regulation of oxidoreductase activity (GO:0051354)3.71623966
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.70820075
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.68684168
52mechanosensory behavior (GO:0007638)3.65621886
53deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.65195879
54regulation of vitamin metabolic process (GO:0030656)3.60680107
55negative regulation of cell killing (GO:0031342)3.59742503
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59742503
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59609173
58protein prenylation (GO:0018342)3.54471008
59prenylation (GO:0097354)3.54471008
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51104272
61regulation of natural killer cell mediated immunity (GO:0002715)3.51104272
62GMP metabolic process (GO:0046037)3.50769871
63regulation of gamma-delta T cell differentiation (GO:0045586)3.48254910
64positive regulation of lymphocyte migration (GO:2000403)3.43726790
65necroptotic process (GO:0070266)3.43698683
66mast cell degranulation (GO:0043303)3.37033216
67mast cell activation involved in immune response (GO:0002279)3.37033216
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31482950
69cytolysis (GO:0019835)3.30788209
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28233543
71regulation of B cell differentiation (GO:0045577)3.28075644
72antigen receptor-mediated signaling pathway (GO:0050851)3.21601124
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20729591
74cellular defense response (GO:0006968)3.10829738
75negative regulation of T cell apoptotic process (GO:0070233)3.09762581
76regulation of T cell chemotaxis (GO:0010819)3.09366908
77positive regulation of T cell chemotaxis (GO:0010820)3.09366908
78granulocyte activation (GO:0036230)3.08581443
79leukocyte degranulation (GO:0043299)3.05186885
80respiratory burst (GO:0045730)3.03359227
81N-glycan processing (GO:0006491)3.02892127
82Peyers patch development (GO:0048541)3.01707377
83mucosal-associated lymphoid tissue development (GO:0048537)3.01707377
84positive regulation of cell fate commitment (GO:0010455)2.99302034
85negative regulation of viral transcription (GO:0032897)2.99098863
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.98252471
87deoxyribose phosphate biosynthetic process (GO:0046385)2.98252471
88positive regulation of cell killing (GO:0031343)2.93077412
89actin nucleation (GO:0045010)2.92795437
90regulation of leukocyte mediated cytotoxicity (GO:0001910)2.92285563
91modulation by host of symbiont transcription (GO:0052472)2.89816407
92modulation by host of viral transcription (GO:0043921)2.89816407
93positive regulation of lymphocyte apoptotic process (GO:0070230)2.89705284
94regulation of gamma-delta T cell activation (GO:0046643)2.88675108
95dopamine biosynthetic process (GO:0042416)2.88292223
96cytoplasmic sequestering of transcription factor (GO:0042994)2.86809031
97regulation of isotype switching to IgG isotypes (GO:0048302)2.86592081
98positive regulation of interleukin-8 secretion (GO:2000484)2.85805826
99C21-steroid hormone biosynthetic process (GO:0006700)2.85540268
100regulation of B cell receptor signaling pathway (GO:0050855)10.8903916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.96038740
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.51935140
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.36302381
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.01585524
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.92650349
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29989083
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29598856
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29207377
9MYB_26560356_Chip-Seq_TH2_Human2.89946470
10RUNX_20019798_ChIP-Seq_JUKART_Human2.83534627
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78248941
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.77966640
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63760364
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.59135273
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57594366
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40765383
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.32276603
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29407851
19GATA3_27048872_Chip-Seq_THYMUS_Human2.12097205
20RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.10676698
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07155958
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.92556269
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90345414
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85134555
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77275165
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77018760
27GATA3_26560356_Chip-Seq_TH2_Human1.74564156
28SCL_19346495_ChIP-Seq_HPC-7_Human1.68579149
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68088485
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68081712
31HTT_18923047_ChIP-ChIP_STHdh_Human1.65436505
32AR_21572438_ChIP-Seq_LNCaP_Human1.63460700
33MYB_26560356_Chip-Seq_TH1_Human1.63190620
34ER_23166858_ChIP-Seq_MCF-7_Human1.55767628
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.53832210
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.50579596
37TAF15_26573619_Chip-Seq_HEK293_Human1.43377999
38TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42814820
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.42742904
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40350340
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36041452
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34019378
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31706437
44VDR_24787735_ChIP-Seq_THP-1_Human1.31372059
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28137344
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24693360
47MAF_26560356_Chip-Seq_TH1_Human1.23986096
48TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21930304
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17331997
50OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12972361
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10904132
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10899580
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10388423
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.08058362
55GATA3_26560356_Chip-Seq_TH1_Human1.08011237
56SMRT_27268052_Chip-Seq_Bcells_Human1.07930861
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07234359
58SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03861636
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01200609
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00590314
61IGF1R_20145208_ChIP-Seq_DFB_Human1.00334097
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99595119
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99358845
64PRDM14_20953172_ChIP-Seq_ESCs_Human0.99258093
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99221123
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98849164
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98150275
68EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96041370
69P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95911543
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95106072
71WDR5_24793694_ChIP-Seq_LNCAP_Human0.94615962
72VDR_22108803_ChIP-Seq_LS180_Human0.94613897
73FOXH1_21741376_ChIP-Seq_EPCs_Human0.94316396
74PU1_27457419_Chip-Seq_LIVER_Mouse0.93526536
75SPI1_23547873_ChIP-Seq_NB4_Human0.93298967
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93075245
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92887220
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91334707
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90555024
80CEBPB_22108803_ChIP-Seq_LS180_Human0.88879958
81SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87612641
82TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86458056
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86229932
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85921021
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85117969
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84883325
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83234622
88MAF_26560356_Chip-Seq_TH2_Human0.83103342
89GABP_17652178_ChIP-ChIP_JURKAT_Human0.82622833
90IRF1_19129219_ChIP-ChIP_H3396_Human0.82068746
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81402711
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81031115
93VDR_23849224_ChIP-Seq_CD4+_Human0.80896449
94ESRRB_18555785_Chip-Seq_ESCs_Mouse0.80044714
95UTX_26944678_Chip-Seq_JUKART_Human0.79580055
96ETV1_20927104_ChIP-Seq_GIST48_Human0.79391244
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79337488
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.79193737
99PU_27001747_Chip-Seq_BMDM_Mouse0.78926276
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.78268984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.85391183
2MP0003763_abnormal_thymus_physiology5.85575717
3MP0005671_abnormal_response_to4.09570133
4MP0001873_stomach_inflammation4.02849474
5MP0008260_abnormal_autophagy3.64612946
6MP0000569_abnormal_digit_pigmentation3.00951795
7MP0006082_CNS_inflammation2.71787858
8MP0005387_immune_system_phenotype2.67715291
9MP0001790_abnormal_immune_system2.67715291
10MP0009333_abnormal_splenocyte_physiolog2.54063544
11MP0001835_abnormal_antigen_presentation2.42045027
12MP0005000_abnormal_immune_tolerance2.41058155
13MP0003283_abnormal_digestive_organ2.41052852
14MP0005503_abnormal_tendon_morphology2.27952096
15MP0001800_abnormal_humoral_immune2.21593734
16MP0005275_abnormal_skin_tensile2.16259851
17MP0002933_joint_inflammation2.05881143
18MP0003436_decreased_susceptibility_to1.99170673
19MP0002420_abnormal_adaptive_immunity1.98310772
20MP0001819_abnormal_immune_cell1.94512548
21MP0002723_abnormal_immune_serum1.94468205
22MP0000703_abnormal_thymus_morphology1.88411833
23MP0004742_abnormal_vestibular_system1.80472545
24MP0000685_abnormal_immune_system1.78164172
25MP0002166_altered_tumor_susceptibility1.74301794
26MP0002405_respiratory_system_inflammati1.70000735
27MP0009785_altered_susceptibility_to1.68688691
28MP0003866_abnormal_defecation1.67136424
29MP0000716_abnormal_immune_system1.63499514
30MP0002452_abnormal_antigen_presenting1.63211621
31MP0001485_abnormal_pinna_reflex1.62627580
32MP0002398_abnormal_bone_marrow1.59819077
33MP0003183_abnormal_peptide_metabolism1.59384568
34MP0005025_abnormal_response_to1.53858577
35MP0010386_abnormal_urinary_bladder1.53048698
36MP0010155_abnormal_intestine_physiology1.51489232
37MP0001542_abnormal_bone_strength1.44229282
38MP0001845_abnormal_inflammatory_respons1.42188855
39MP0002148_abnormal_hypersensitivity_rea1.41272108
40MP0002876_abnormal_thyroid_physiology1.38939546
41MP0002722_abnormal_immune_system1.37251671
42MP0000689_abnormal_spleen_morphology1.31750027
43MP0003786_premature_aging1.30095181
44MP0001666_abnormal_nutrient_absorption1.28394153
45MP0003938_abnormal_ear_development1.26997157
46MP0003448_altered_tumor_morphology1.25950123
47MP0005075_abnormal_melanosome_morpholog1.24719711
48MP0002277_abnormal_respiratory_mucosa1.22336856
49MP0001533_abnormal_skeleton_physiology1.21230117
50MP0001188_hyperpigmentation1.20112572
51MP0002419_abnormal_innate_immunity1.18448894
52MP0005389_reproductive_system_phenotype1.18317613
53MP0001919_abnormal_reproductive_system1.16295648
54MP0000681_abnormal_thyroid_gland1.14118396
55MP0002006_tumorigenesis1.14082008
56MP0002429_abnormal_blood_cell1.11542993
57MP0000604_amyloidosis1.03288620
58MP0005408_hypopigmentation1.01861107
59MP0003195_calcinosis1.01494310
60MP0004381_abnormal_hair_follicle1.00246080
61MP0006072_abnormal_retinal_apoptosis0.98559337
62MP0004883_abnormal_blood_vessel0.98200519
63MP0002282_abnormal_trachea_morphology0.97519007
64MP0001243_abnormal_dermal_layer0.96948966
65MP0004947_skin_inflammation0.96363609
66MP0008438_abnormal_cutaneous_collagen0.91088504
67MP0005551_abnormal_eye_electrophysiolog0.89088550
68MP0008007_abnormal_cellular_replicative0.85250715
69MP0005464_abnormal_platelet_physiology0.84900955
70MP0001905_abnormal_dopamine_level0.84174004
71MP0002998_abnormal_bone_remodeling0.81523524
72MP0002160_abnormal_reproductive_system0.81174958
73MP0000013_abnormal_adipose_tissue0.79981959
74MP0000858_altered_metastatic_potential0.79155368
75MP0003252_abnormal_bile_duct0.78890870
76MP0002108_abnormal_muscle_morphology0.75341840
77MP0001984_abnormal_olfaction0.72665473
78MP0005645_abnormal_hypothalamus_physiol0.71473074
79MP0003567_abnormal_fetal_cardiomyocyte0.70927301
80MP0008569_lethality_at_weaning0.69670962
81MP0003724_increased_susceptibility_to0.69310149
82MP0005023_abnormal_wound_healing0.67816287
83MP0005390_skeleton_phenotype0.66326634
84MP0002019_abnormal_tumor_incidence0.66058187
85MP0001986_abnormal_taste_sensitivity0.65559737
86MP0001663_abnormal_digestive_system0.64285657
87MP0005058_abnormal_lysosome_morphology0.60373966
88MP0005253_abnormal_eye_physiology0.59550924
89MP0001191_abnormal_skin_condition0.58971689
90MP0001765_abnormal_ion_homeostasis0.58777735
91MP0005164_abnormal_response_to0.58774884
92MP0000371_diluted_coat_color0.57401417
93MP0009115_abnormal_fat_cell0.56974913
94MP0002136_abnormal_kidney_physiology0.55320553
95MP0002132_abnormal_respiratory_system0.54264973
96MP0001270_distended_abdomen0.52535197
97MP0009763_increased_sensitivity_to0.52112209
98MP0001958_emphysema0.48769086
99MP0003690_abnormal_glial_cell0.45673293
100MP0001502_abnormal_circadian_rhythm0.43994269

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)6.74513736
2B lymphocytopenia (HP:0010976)6.66306449
3T lymphocytopenia (HP:0005403)6.31132888
4Abnormality of B cell number (HP:0010975)5.93619171
5Abnormality of T cell number (HP:0011839)5.79692093
6Thyroiditis (HP:0100646)4.75836761
7Autoimmune hemolytic anemia (HP:0001890)4.67266982
8Aortic dissection (HP:0002647)4.57168911
9IgG deficiency (HP:0004315)4.21270772
10Diplopia (HP:0000651)4.19987860
11Abnormality of binocular vision (HP:0011514)4.19987860
12Severe combined immunodeficiency (HP:0004430)4.16255755
13Increased IgM level (HP:0003496)3.97566812
14Hypoplasia of the thymus (HP:0000778)3.87157610
15Abnormality of the prostate (HP:0008775)3.85086082
16Combined immunodeficiency (HP:0005387)3.74874447
17Mediastinal lymphadenopathy (HP:0100721)3.53059954
18Stomatitis (HP:0010280)3.50521899
19Lymphopenia (HP:0001888)3.49282179
20Increased corneal curvature (HP:0100692)3.47608477
21Keratoconus (HP:0000563)3.47608477
22Spondylolisthesis (HP:0003302)3.45441992
23Elevated erythrocyte sedimentation rate (HP:0003565)3.41442297
24Interstitial pulmonary disease (HP:0006530)3.35556647
25Abnormality of eosinophils (HP:0001879)3.34187219
26Ureteral stenosis (HP:0000071)3.33936721
27Ureteral obstruction (HP:0006000)3.26026197
28Chronic diarrhea (HP:0002028)3.25836031
29Chest pain (HP:0100749)3.25589201
30Abnormality of T cells (HP:0002843)3.25395993
31Amaurosis fugax (HP:0100576)3.24561196
32Recurrent bronchitis (HP:0002837)3.24460502
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.17480422
34Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03525078
35Decreased central vision (HP:0007663)2.98392139
36Hypoproteinemia (HP:0003075)2.98022121
37Obstructive lung disease (HP:0006536)2.91061309
38Chronic obstructive pulmonary disease (HP:0006510)2.91061309
39Arterial thrombosis (HP:0004420)2.86566918
40Chronic mucocutaneous candidiasis (HP:0002728)2.82812509
41Recurrent cutaneous fungal infections (HP:0011370)2.82812509
42Attenuation of retinal blood vessels (HP:0007843)2.82440405
43Encephalitis (HP:0002383)2.80781650
44Hemoptysis (HP:0002105)2.77109213
45Hemiplegia (HP:0002301)2.73032993
46Gangrene (HP:0100758)2.71870393
47Meningitis (HP:0001287)2.68953463
48Leukocytosis (HP:0001974)2.68109621
49Pulmonary infiltrates (HP:0002113)2.63501753
50Alveolar cell carcinoma (HP:0006519)2.61168341
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60035160
52Abnormality of alanine metabolism (HP:0010916)2.60035160
53Hyperalaninemia (HP:0003348)2.60035160
54Subacute progressive viral hepatitis (HP:0006572)2.59716174
55Abnormal rod and cone electroretinograms (HP:0008323)2.54121191
56Eosinophilia (HP:0001880)2.43130863
57Neoplasm of the tracheobronchial system (HP:0100552)2.40699835
58Vasculitis (HP:0002633)2.38480155
59Pancytopenia (HP:0001876)2.37795043
60Joint swelling (HP:0001386)2.34737950
61Hepatitis (HP:0012115)2.34514408
62Bronchitis (HP:0012387)2.33605970
63Recurrent fungal infections (HP:0002841)2.30690688
64IgM deficiency (HP:0002850)2.30218981
65Acute hepatic failure (HP:0006554)2.27479274
66Abnormality of macrophages (HP:0004311)2.24856240
67Recurrent sinusitis (HP:0011108)2.23291925
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22680416
69Macular degeneration (HP:0000608)2.21881091
70Conjugated hyperbilirubinemia (HP:0002908)2.21073259
71Myositis (HP:0100614)2.20581597
72Severe visual impairment (HP:0001141)2.19654736
73Abnormality of incisor morphology (HP:0011063)2.16904691
74Abnormality of male internal genitalia (HP:0000022)2.11215543
75Abnormality of the pleura (HP:0002103)2.10577965
76Premature graying of hair (HP:0002216)2.07056680
77Recurrent otitis media (HP:0000403)2.05860932
78Nephrogenic diabetes insipidus (HP:0009806)2.04996661
79Anorexia (HP:0002039)2.04541672
80Amyotrophic lateral sclerosis (HP:0007354)2.04527810
81Dilatation of the ascending aorta (HP:0005111)2.04424359
82Pulmonary embolism (HP:0002204)2.03502139
83Agammaglobulinemia (HP:0004432)1.99942044
84Retinal dysplasia (HP:0007973)1.99394476
85Pigmentary retinal degeneration (HP:0001146)1.96680847
86Skin rash (HP:0000988)1.95841354
87Cellular immunodeficiency (HP:0005374)1.92817499
88Infantile muscular hypotonia (HP:0008947)1.88360364
89Granulocytopenia (HP:0001913)1.86361552
90Prominent nose (HP:0000448)1.84961511
91Recurrent skin infections (HP:0001581)1.82551039
92Lymphoma (HP:0002665)1.81084719
93Spastic diplegia (HP:0001264)1.77472623
94Renal tubular acidosis (HP:0001947)1.76983021
95Absent frontal sinuses (HP:0002688)1.76683383
96Autoimmune thrombocytopenia (HP:0001973)1.76456286
97Hypergammaglobulinemia (HP:0010702)1.74681324
98Recurrent bacterial skin infections (HP:0005406)1.74427508
99Abnormality of the pericardium (HP:0001697)1.73685933
100Glomerulopathy (HP:0100820)1.73046029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.58889240
2MAP4K14.35684994
3ITK3.76675098
4TXK3.66157180
5TEC2.75972749
6MAP3K112.72826462
7CDK82.46571973
8TAOK32.43150636
9AKT32.31107171
10TESK22.29417314
11CSK2.26484398
12FRK2.15538766
13GRK62.09204602
14SYK1.99645296
15BTK1.96613144
16TBK11.91868368
17PRKCH1.86533765
18PRKCQ1.53671349
19IKBKE1.50581016
20TNK21.43294086
21PRKD21.43221425
22IRAK11.40122908
23ZAP701.39309427
24CDK41.39071913
25GRK51.35785900
26MAP3K71.35703297
27BUB11.29934462
28CSF1R1.29760889
29PIK3CG1.27191117
30MAP3K141.26167994
31JAK31.24186561
32DYRK1B1.19338138
33LCK1.18999797
34MAP2K61.18233223
35LYN1.13436234
36NUAK11.12260669
37BLK1.07490173
38MARK31.07005370
39MAP2K71.04795157
40FGFR10.97443350
41MELK0.96053065
42GRK10.93964156
43CDK90.92693461
44PLK20.91834542
45DYRK1A0.91546201
46MAP3K10.90975216
47IRAK40.90434698
48CAMKK20.88738069
49NLK0.87182610
50PRKD30.86838859
51SGK20.86781993
52ZAK0.79907240
53FES0.77663277
54IKBKB0.77395130
55STK40.76036875
56STK380.73387006
57VRK10.73282599
58BCR0.68634772
59ADRBK20.68473233
60IRAK20.63235338
61BRSK20.62254099
62SGK30.61306329
63AURKA0.59054923
64PKN10.58146725
65FYN0.51475241
66MARK20.50391706
67IGF1R0.49879087
68ACVR1B0.49638323
69ERBB30.48756796
70SGK2230.48539621
71SGK4940.48539621
72TRPM70.48107378
73PRKCE0.47693555
74PTK2B0.46066017
75ERN10.44648484
76RPS6KA50.44474487
77HCK0.44018895
78BMPR1B0.42319407
79PAK20.42096559
80PDGFRB0.38784645
81FGFR30.38706173
82PRKCA0.38469872
83TGFBR20.37618945
84FGFR20.36768486
85OBSCN0.36131549
86PRKCZ0.35805695
87ERBB20.35526257
88EGFR0.30645430
89TAF10.30430751
90GSK3A0.29510681
91INSR0.29269059
92PRKACA0.29148110
93INSRR0.29096824
94CAMKK10.28462079
95MAPKAPK20.28274758
96PRKCD0.28064872
97WNK40.27617023
98WNK10.27446507
99CAMK40.26474931
100LATS10.25932474

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.76586042
2T cell receptor signaling pathway_Homo sapiens_hsa046603.89995363
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.94785582
4Antigen processing and presentation_Homo sapiens_hsa046122.89311124
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.88648485
6Hematopoietic cell lineage_Homo sapiens_hsa046402.87499026
7Graft-versus-host disease_Homo sapiens_hsa053322.40429223
8Measles_Homo sapiens_hsa051622.37962462
9Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.19469755
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10790573
11Proteasome_Homo sapiens_hsa030502.02434427
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93883934
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.85367984
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83596111
15Autoimmune thyroid disease_Homo sapiens_hsa053201.81355697
16Salmonella infection_Homo sapiens_hsa051321.80669578
17Osteoclast differentiation_Homo sapiens_hsa043801.58979083
18Allograft rejection_Homo sapiens_hsa053301.54141116
19Type I diabetes mellitus_Homo sapiens_hsa049401.53184110
20Homologous recombination_Homo sapiens_hsa034401.51326606
21Ether lipid metabolism_Homo sapiens_hsa005651.50912690
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33084462
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31888824
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22032037
25Rheumatoid arthritis_Homo sapiens_hsa053231.16883885
26TNF signaling pathway_Homo sapiens_hsa046681.14694937
27Olfactory transduction_Homo sapiens_hsa047401.10372981
28Taste transduction_Homo sapiens_hsa047421.04774874
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01103205
30Oxidative phosphorylation_Homo sapiens_hsa001900.98165822
31Chemokine signaling pathway_Homo sapiens_hsa040620.97746891
32Sphingolipid metabolism_Homo sapiens_hsa006000.95817108
33Malaria_Homo sapiens_hsa051440.95673945
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93741098
35Linoleic acid metabolism_Homo sapiens_hsa005910.93251794
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92742988
37Shigellosis_Homo sapiens_hsa051310.91512575
38Nucleotide excision repair_Homo sapiens_hsa034200.88886277
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88869004
40Parkinsons disease_Homo sapiens_hsa050120.87577166
41Fanconi anemia pathway_Homo sapiens_hsa034600.83427096
42Systemic lupus erythematosus_Homo sapiens_hsa053220.83204154
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80595465
44Mismatch repair_Homo sapiens_hsa034300.77976221
45African trypanosomiasis_Homo sapiens_hsa051430.72495598
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72252321
47Renin secretion_Homo sapiens_hsa049240.71967858
48Phototransduction_Homo sapiens_hsa047440.70083652
49Colorectal cancer_Homo sapiens_hsa052100.69184597
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.66681637
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62865222
52Butanoate metabolism_Homo sapiens_hsa006500.60267835
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59509297
54Melanoma_Homo sapiens_hsa052180.58072230
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56893052
56Alzheimers disease_Homo sapiens_hsa050100.56086687
57Long-term potentiation_Homo sapiens_hsa047200.55838747
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54906975
59Protein export_Homo sapiens_hsa030600.54288223
60HTLV-I infection_Homo sapiens_hsa051660.54263574
61Staphylococcus aureus infection_Homo sapiens_hsa051500.53392387
62Renal cell carcinoma_Homo sapiens_hsa052110.52364606
63Leishmaniasis_Homo sapiens_hsa051400.52304693
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52101986
65Alcoholism_Homo sapiens_hsa050340.51147882
66Apoptosis_Homo sapiens_hsa042100.49931546
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49903591
68Platelet activation_Homo sapiens_hsa046110.49493908
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.49461156
70p53 signaling pathway_Homo sapiens_hsa041150.47880526
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46705124
72Amphetamine addiction_Homo sapiens_hsa050310.45085692
73Pancreatic cancer_Homo sapiens_hsa052120.44571006
74Herpes simplex infection_Homo sapiens_hsa051680.44325581
75Non-small cell lung cancer_Homo sapiens_hsa052230.40894625
76Chronic myeloid leukemia_Homo sapiens_hsa052200.40550227
77Regulation of autophagy_Homo sapiens_hsa041400.39888348
78ErbB signaling pathway_Homo sapiens_hsa040120.39423585
79Endocytosis_Homo sapiens_hsa041440.38983961
80Ras signaling pathway_Homo sapiens_hsa040140.38296486
81MAPK signaling pathway_Homo sapiens_hsa040100.38049339
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36174663
83Hepatitis B_Homo sapiens_hsa051610.35459788
84B cell receptor signaling pathway_Homo sapiens_hsa046620.34474750
85Glioma_Homo sapiens_hsa052140.34106267
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33442717
87Cholinergic synapse_Homo sapiens_hsa047250.31235959
88FoxO signaling pathway_Homo sapiens_hsa040680.30302596
89Viral myocarditis_Homo sapiens_hsa054160.28684214
90TGF-beta signaling pathway_Homo sapiens_hsa043500.27126180
91Arachidonic acid metabolism_Homo sapiens_hsa005900.26064024
92Epstein-Barr virus infection_Homo sapiens_hsa051690.25932143
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.25094646
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25006113
95Huntingtons disease_Homo sapiens_hsa050160.23220260
96Pertussis_Homo sapiens_hsa051330.23124473
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22875025
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22861038
99Legionellosis_Homo sapiens_hsa051340.21904346
100RNA degradation_Homo sapiens_hsa030180.21136902

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