TRAJ27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.47675487
2negative regulation of T cell apoptotic process (GO:0070233)5.93804843
3negative T cell selection (GO:0043383)5.76536390
4positive regulation of tolerance induction (GO:0002645)5.66538077
5positive T cell selection (GO:0043368)5.58037833
6regulation of T cell tolerance induction (GO:0002664)5.57514312
7T cell migration (GO:0072678)5.51522357
8pyrimidine nucleoside catabolic process (GO:0046135)5.39414071
9regulation of B cell differentiation (GO:0045577)5.34930756
10regulation of lymphocyte chemotaxis (GO:1901623)5.24732301
11negative regulation by host of viral transcription (GO:0043922)5.19970009
12eosinophil chemotaxis (GO:0048245)5.18656937
13positive regulation of B cell differentiation (GO:0045579)5.13822750
14positive regulation of gamma-delta T cell activation (GO:0046645)5.13352627
15monocyte chemotaxis (GO:0002548)5.10180263
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.81797623
17regulation of B cell receptor signaling pathway (GO:0050855)4.77139507
18negative regulation of viral genome replication (GO:0045071)4.75949634
19positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.71001793
20eosinophil migration (GO:0072677)4.69182969
21regulation of tolerance induction (GO:0002643)4.59382162
22regulation of activation of Janus kinase activity (GO:0010533)4.58087551
23regulation of regulatory T cell differentiation (GO:0045589)4.48376281
24positive regulation of calcium-mediated signaling (GO:0050850)4.44607012
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40766635
26macrophage chemotaxis (GO:0048246)4.36102709
27regulation of T cell chemotaxis (GO:0010819)4.34200973
28positive regulation of T cell chemotaxis (GO:0010820)4.34200973
29cytolysis (GO:0019835)4.33919412
30proteasome assembly (GO:0043248)4.29967586
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.27468579
32T cell selection (GO:0045058)4.24902147
33regulation of gamma-delta T cell differentiation (GO:0045586)4.23841852
34thymic T cell selection (GO:0045061)4.20043443
35positive thymic T cell selection (GO:0045059)4.17851183
36regulation of natural killer cell mediated immunity (GO:0002715)4.16316031
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.16316031
38lymphocyte chemotaxis (GO:0048247)4.15089438
39negative thymic T cell selection (GO:0045060)4.13891475
40regulation of T cell apoptotic process (GO:0070232)4.12017095
41cellular response to interleukin-15 (GO:0071350)4.11388532
42positive regulation of lymphocyte migration (GO:2000403)4.08943205
43Arp2/3 complex-mediated actin nucleation (GO:0034314)4.05513128
44T cell receptor signaling pathway (GO:0050852)4.01010107
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.99560326
46negative regulation of lymphocyte apoptotic process (GO:0070229)3.97778515
47negative regulation of organelle assembly (GO:1902116)3.97214877
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92126590
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87787050
50cellular defense response (GO:0006968)3.81660190
51positive regulation of cell killing (GO:0031343)3.79533802
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.78920748
53regulation of alpha-beta T cell proliferation (GO:0046640)3.75558611
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74572085
55regulation of T cell mediated cytotoxicity (GO:0001914)3.74326781
56regulation of gamma-delta T cell activation (GO:0046643)3.67790639
57positive regulation of macrophage differentiation (GO:0045651)3.63437396
58positive regulation of monocyte chemotaxis (GO:0090026)3.62796207
59immunoglobulin mediated immune response (GO:0016064)3.60418015
60activated T cell proliferation (GO:0050798)3.59733298
61positive regulation of interleukin-4 production (GO:0032753)3.58607622
62regulation of cell killing (GO:0031341)3.54489891
63actin nucleation (GO:0045010)3.53156053
64regulation of lymphocyte migration (GO:2000401)3.51348978
65negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50908657
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46546023
67regulation of isotype switching to IgG isotypes (GO:0048302)3.46113101
68lymphocyte migration (GO:0072676)3.45598516
69regulation of T cell receptor signaling pathway (GO:0050856)3.44843017
70negative regulation of cell killing (GO:0031342)3.43878020
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43878020
72regulation of calcium-mediated signaling (GO:0050848)3.41907238
73negative regulation of B cell proliferation (GO:0030889)3.41597921
74antigen receptor-mediated signaling pathway (GO:0050851)3.40999175
75negative regulation of viral transcription (GO:0032897)3.40095649
76regulation of mononuclear cell migration (GO:0071675)3.34098648
77negative regulation of viral process (GO:0048525)3.33073088
78response to interleukin-15 (GO:0070672)3.32577363
79regulation of macrophage chemotaxis (GO:0010758)3.32488233
80regulation of viral genome replication (GO:0045069)3.28527263
81interferon-gamma production (GO:0032609)3.19603952
82positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18603651
83positive regulation of T cell apoptotic process (GO:0070234)3.17500168
84regulation of defense response to virus by virus (GO:0050690)3.16989644
85negative regulation of stress fiber assembly (GO:0051497)3.14581638
86T cell costimulation (GO:0031295)3.14410961
87pyrimidine-containing compound catabolic process (GO:0072529)3.14288413
88pyrimidine ribonucleoside metabolic process (GO:0046131)3.13089970
89regulation of chronic inflammatory response (GO:0002676)3.12852478
90B cell mediated immunity (GO:0019724)3.11418754
91modulation by host of symbiont transcription (GO:0052472)3.11312359
92modulation by host of viral transcription (GO:0043921)3.11312359
93lymphocyte costimulation (GO:0031294)3.10597555
94positive regulation of interleukin-2 production (GO:0032743)3.09216025
95granulocyte activation (GO:0036230)3.08539547
96cytidine deamination (GO:0009972)13.1510523
97cytidine metabolic process (GO:0046087)13.1510523
98cytidine catabolic process (GO:0006216)13.1510523
99pyrimidine ribonucleoside catabolic process (GO:0046133)11.6713627
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.0563358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.40128745
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.37090936
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.36502456
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.28955761
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.20681434
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.68209499
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51908010
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.13691918
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09962494
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07222082
11MYB_26560356_Chip-Seq_TH2_Human3.01524392
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84032347
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76767206
14RUNX_20019798_ChIP-Seq_JUKART_Human2.72991217
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.72878723
16GATA3_27048872_Chip-Seq_THYMUS_Human2.61011193
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.48186010
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.28066009
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25264797
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12887697
21MYB_26560356_Chip-Seq_TH1_Human2.12253598
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10113802
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99657395
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99373512
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92718278
26RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.90037087
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79722522
28UTX_26944678_Chip-Seq_JUKART_Human1.71454192
29HTT_18923047_ChIP-ChIP_STHdh_Human1.71445962
30PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.65194859
31MAF_26560356_Chip-Seq_TH1_Human1.63482845
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61149712
33GATA3_26560356_Chip-Seq_TH2_Human1.44853563
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.42628076
35MAF_26560356_Chip-Seq_TH2_Human1.41359534
36BCL6_27268052_Chip-Seq_Bcells_Human1.39180148
37SCL_19346495_ChIP-Seq_HPC-7_Human1.37003875
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29051019
39SPI1_23547873_ChIP-Seq_NB4_Human1.26497771
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22906925
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18322148
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10948209
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07802726
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06950688
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06336775
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04862839
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.04616222
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03613604
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.03392774
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03069485
51VDR_23849224_ChIP-Seq_CD4+_Human1.01984008
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00488268
53PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97626423
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97345674
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93714556
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93240942
57EST1_17652178_ChIP-ChIP_JURKAT_Human0.92947805
58CTCF_20526341_ChIP-Seq_ESCs_Human0.92665112
59HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92320233
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90041733
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86931207
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84910870
63RUNX1_22412390_ChIP-Seq_EML_Mouse0.84759369
64GATA3_26560356_Chip-Seq_TH1_Human0.84550657
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83701810
66SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83594737
67NANOG_20526341_ChIP-Seq_ESCs_Human0.81953386
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81058047
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79595312
70FOXP3_21729870_ChIP-Seq_TREG_Human0.79378654
71P300_27268052_Chip-Seq_Bcells_Human0.78482619
72TAF2_19829295_ChIP-Seq_ESCs_Human0.78414996
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77348267
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76126720
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.74067243
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73963033
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73343322
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.72303284
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.72292691
80VDR_24787735_ChIP-Seq_THP-1_Human0.72270504
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71052568
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70966326
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70666450
84MYC_19829295_ChIP-Seq_ESCs_Human0.70203306
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.70074820
86TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69034976
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.68879658
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68836538
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68738451
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67901725
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.67104914
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.67030589
93BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66608628
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66210000
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66108882
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65623303
97VDR_24763502_ChIP-Seq_THP-1_Human0.64376303
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.64319675
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.64319675
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.64198814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.66633934
2MP0003763_abnormal_thymus_physiology5.78656487
3MP0009333_abnormal_splenocyte_physiolog3.66735417
4MP0006082_CNS_inflammation3.51687979
5MP0001873_stomach_inflammation3.32726563
6MP0009785_altered_susceptibility_to3.27067102
7MP0005000_abnormal_immune_tolerance3.02801723
8MP0001835_abnormal_antigen_presentation2.88715251
9MP0002723_abnormal_immune_serum2.61133562
10MP0001800_abnormal_humoral_immune2.61123544
11MP0002405_respiratory_system_inflammati2.60829280
12MP0002420_abnormal_adaptive_immunity2.60739460
13MP0001790_abnormal_immune_system2.57146564
14MP0005387_immune_system_phenotype2.57146564
15MP0002148_abnormal_hypersensitivity_rea2.52239695
16MP0003045_fibrosis2.48947253
17MP0001819_abnormal_immune_cell2.47725533
18MP0000703_abnormal_thymus_morphology2.41795943
19MP0003866_abnormal_defecation2.41578776
20MP0003786_premature_aging2.40933251
21MP0005025_abnormal_response_to2.38841511
22MP0002398_abnormal_bone_marrow2.15538397
23MP0000716_abnormal_immune_system2.13385452
24MP0003448_altered_tumor_morphology2.11543527
25MP0001188_hyperpigmentation2.00813297
26MP0002452_abnormal_antigen_presenting1.87012476
27MP0002722_abnormal_immune_system1.80529058
28MP0002277_abnormal_respiratory_mucosa1.77164766
29MP0004947_skin_inflammation1.75462772
30MP0000689_abnormal_spleen_morphology1.71175993
31MP0010155_abnormal_intestine_physiology1.70407441
32MP0002166_altered_tumor_susceptibility1.69432890
33MP0000685_abnormal_immune_system1.68999451
34MP0001905_abnormal_dopamine_level1.63455250
35MP0005464_abnormal_platelet_physiology1.62862516
36MP0001919_abnormal_reproductive_system1.58291828
37MP0001845_abnormal_inflammatory_respons1.54275323
38MP0002429_abnormal_blood_cell1.54014641
39MP0002102_abnormal_ear_morphology1.44285272
40MP0002933_joint_inflammation1.42614518
41MP0002419_abnormal_innate_immunity1.41959079
42MP0009763_increased_sensitivity_to1.40104874
43MP0008007_abnormal_cellular_replicative1.36417705
44MP0001984_abnormal_olfaction1.29235159
45MP0000569_abnormal_digit_pigmentation1.27162859
46MP0002006_tumorigenesis1.23489886
47MP0001853_heart_inflammation1.16077690
48MP0004381_abnormal_hair_follicle1.14863217
49MP0005377_hearing/vestibular/ear_phenot1.01036119
50MP0003878_abnormal_ear_physiology1.01036119
51MP0008469_abnormal_protein_level0.99748866
52MP0008873_increased_physiological_sensi0.98852100
53MP0006072_abnormal_retinal_apoptosis0.98114664
54MP0000858_altered_metastatic_potential0.96016906
55MP0000920_abnormal_myelination0.94310580
56MP0003724_increased_susceptibility_to0.90300270
57MP0003567_abnormal_fetal_cardiomyocyte0.88779462
58MP0002019_abnormal_tumor_incidence0.86975991
59MP0010307_abnormal_tumor_latency0.85541212
60MP0009643_abnormal_urine_homeostasis0.83320614
61MP0004742_abnormal_vestibular_system0.83236798
62MP0002138_abnormal_hepatobiliary_system0.83236189
63MP0005389_reproductive_system_phenotype0.82082626
64MP0002653_abnormal_ependyma_morphology0.81557423
65MP0003436_decreased_susceptibility_to0.81090509
66MP0001243_abnormal_dermal_layer0.80125875
67MP0005075_abnormal_melanosome_morpholog0.78160167
68MP0002136_abnormal_kidney_physiology0.77617162
69MP0003646_muscle_fatigue0.76824884
70MP0009765_abnormal_xenobiotic_induced0.76409073
71MP0001542_abnormal_bone_strength0.75218281
72MP0002998_abnormal_bone_remodeling0.74707280
73MP0004142_abnormal_muscle_tone0.74446496
74MP0004145_abnormal_muscle_electrophysio0.74181316
75MP0003183_abnormal_peptide_metabolism0.71563696
76MP0005410_abnormal_fertilization0.70822357
77MP0008995_early_reproductive_senescence0.67774003
78MP0005645_abnormal_hypothalamus_physiol0.66663110
79MP0002168_other_aberrant_phenotype0.66593123
80MP0003137_abnormal_impulse_conducting0.65927921
81MP0005166_decreased_susceptibility_to0.64287693
82MP0005253_abnormal_eye_physiology0.62745502
83MP0005409_darkened_coat_color0.60129789
84MP0003011_delayed_dark_adaptation0.59167344
85MP0002877_abnormal_melanocyte_morpholog0.58920386
86MP0000647_abnormal_sebaceous_gland0.57666640
87MP0001765_abnormal_ion_homeostasis0.56803890
88MP0000639_abnormal_adrenal_gland0.56226427
89MP0003795_abnormal_bone_structure0.54872458
90MP0002638_abnormal_pupillary_reflex0.51357039
91MP0002909_abnormal_adrenal_gland0.50450536
92MP0002163_abnormal_gland_morphology0.48402314
93MP0001502_abnormal_circadian_rhythm0.46018637
94MP0002132_abnormal_respiratory_system0.45744223
95MP0002693_abnormal_pancreas_physiology0.42612106
96MP0001663_abnormal_digestive_system0.41560311
97MP0001968_abnormal_touch/_nociception0.40911545
98MP0002090_abnormal_vision0.40071995
99MP0001119_abnormal_female_reproductive0.39974445
100MP0001191_abnormal_skin_condition0.38486340

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)9.78620780
2T lymphocytopenia (HP:0005403)8.59414029
3Abnormality of T cell number (HP:0011839)7.64846552
4IgG deficiency (HP:0004315)4.89902400
5Hypoplasia of the thymus (HP:0000778)4.85826412
6IgM deficiency (HP:0002850)4.72700071
7Autoimmune hemolytic anemia (HP:0001890)4.66503473
8Abnormality of T cells (HP:0002843)4.62602505
9Cutaneous melanoma (HP:0012056)4.25319881
10Severe combined immunodeficiency (HP:0004430)4.22502775
11Abnormality of macrophages (HP:0004311)4.20909155
12Elevated erythrocyte sedimentation rate (HP:0003565)4.17820210
13Hypoproteinemia (HP:0003075)4.14952963
14Abnormality of eosinophils (HP:0001879)4.11426969
15Thyroiditis (HP:0100646)3.64763722
16Combined immunodeficiency (HP:0005387)3.53641249
17Rib fusion (HP:0000902)3.51122177
18Stomatitis (HP:0010280)3.49549427
19Eosinophilia (HP:0001880)3.43901295
20Lymphopenia (HP:0001888)3.35768566
21Recurrent bronchitis (HP:0002837)3.25549357
22Leukocytosis (HP:0001974)3.13567472
23Pancytopenia (HP:0001876)3.13314608
24Recurrent cutaneous fungal infections (HP:0011370)3.09127390
25Chronic mucocutaneous candidiasis (HP:0002728)3.09127390
26Abnormality of cells of the lymphoid lineage (HP:0012140)3.06068159
27Amyotrophic lateral sclerosis (HP:0007354)3.05893958
28Anomalous pulmonary venous return (HP:0010772)3.02885248
29Chronic diarrhea (HP:0002028)3.01698242
30Abnormality of the prostate (HP:0008775)3.00365117
31Joint swelling (HP:0001386)2.92566251
32Hemiplegia (HP:0002301)2.89513518
33Menstrual irregularities (HP:0000858)2.86219644
34Increased IgM level (HP:0003496)2.83081683
35Lymphoma (HP:0002665)2.82672272
36Granulocytopenia (HP:0001913)2.80683323
37Encephalitis (HP:0002383)2.78028952
38Abnormality of the pulmonary veins (HP:0011718)2.68445143
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.61909564
40Recurrent viral infections (HP:0004429)2.60229644
41Malignant hyperthermia (HP:0002047)2.59201340
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.58824716
43Gastrointestinal infarctions (HP:0005244)2.54273479
44Obstructive lung disease (HP:0006536)2.44683926
45Chronic obstructive pulmonary disease (HP:0006510)2.44683926
46Vasculitis (HP:0002633)2.42291289
47Bronchitis (HP:0012387)2.42281781
48Abnormal drinking behavior (HP:0030082)2.40793504
49Polydipsia (HP:0001959)2.40793504
50Purpura (HP:0000979)2.32109113
51Agammaglobulinemia (HP:0004432)2.31005159
52Meningitis (HP:0001287)2.30978119
53Abnormal albumin level (HP:0012116)2.30366659
54Hypoalbuminemia (HP:0003073)2.30366659
55Confusion (HP:0001289)2.28227906
56Recurrent bacterial skin infections (HP:0005406)2.26913562
57Recurrent skin infections (HP:0001581)2.26328685
58Increased cerebral lipofuscin (HP:0011813)2.24986812
59Chest pain (HP:0100749)2.24070670
60Ureteral stenosis (HP:0000071)2.17094244
61Aplasia/Hypoplasia of the thymus (HP:0010515)2.16525954
62Aplasia/hypoplasia of the uterus (HP:0008684)2.13701722
63Polyuria (HP:0000103)2.10342091
64Acute hepatic failure (HP:0006554)2.10194553
65Fused cervical vertebrae (HP:0002949)2.08874433
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07764395
67Ureteral obstruction (HP:0006000)2.07009071
68Generalized aminoaciduria (HP:0002909)2.02538314
69Abnormality of binocular vision (HP:0011514)2.00862761
70Diplopia (HP:0000651)2.00862761
71Oligomenorrhea (HP:0000876)2.00659056
72Autoimmune thrombocytopenia (HP:0001973)1.98913345
73Amniotic constriction ring (HP:0009775)1.93496957
74Abnormality of placental membranes (HP:0011409)1.93496957
75Recurrent fungal infections (HP:0002841)1.92744807
76Symphalangism affecting the phalanges of the hand (HP:0009773)1.91710435
77Spontaneous hematomas (HP:0007420)1.91016967
78Alveolar cell carcinoma (HP:0006519)1.90832992
79Recurrent otitis media (HP:0000403)1.89523358
80Failure to thrive in infancy (HP:0001531)1.88549164
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85093462
82Hyponatremia (HP:0002902)1.84199915
83Glucose intolerance (HP:0000833)1.84144390
84Periodontitis (HP:0000704)1.83945361
85Gangrene (HP:0100758)1.83664027
86Methylmalonic aciduria (HP:0012120)1.83387987
87Type I diabetes mellitus (HP:0100651)1.83333814
88Respiratory distress (HP:0002098)1.81456597
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81026236
90Abnormality of alanine metabolism (HP:0010916)1.81026236
91Hyperalaninemia (HP:0003348)1.81026236
92Aplasia of the musculature (HP:0100854)1.80312167
93Pustule (HP:0200039)1.78997199
94Popliteal pterygium (HP:0009756)1.78729324
95Hypergammaglobulinemia (HP:0010702)1.78554712
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77538422
97Abnormal urine output (HP:0012590)1.76076388
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74593339
99Recurrent abscess formation (HP:0002722)1.74268711
100Hypokalemia (HP:0002900)1.73865339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.12905204
2KDR5.78132327
3MAP4K15.11800347
4ITK3.53022666
5TESK23.32454625
6CSK2.80697908
7SCYL22.77028636
8BUB12.63967663
9FES2.63211843
10TNK22.60673594
11TYRO32.49555555
12TAOK32.37710939
13ZAP702.24951976
14MAPKAPK32.19719150
15SYK1.77690339
16MAP2K71.73872901
17PRKCQ1.73563314
18MAP3K111.71939447
19TEC1.60879772
20BTK1.58159457
21LCK1.57982418
22MST41.52187359
23TESK11.51954828
24GRK61.37435770
25STK38L1.35609272
26IKBKE1.31502635
27FGFR11.30683393
28PDGFRB1.29321365
29ADRBK21.21611733
30STK381.09329100
31JAK31.07243374
32BCKDK1.04982951
33IKBKB1.03833620
34TBK11.02452176
35RIPK40.99533300
36LIMK10.95060244
37LYN0.86743128
38CSF1R0.86319727
39ACVR1B0.86136882
40AKT30.82396057
41HCK0.80507001
42PIK3CA0.75420195
43FYN0.72635446
44FGFR20.71328323
45FRK0.67136271
46INSR0.66971257
47NEK60.60576729
48ATR0.59401847
49AURKA0.56449112
50PIK3CG0.55602251
51CAMKK20.52557808
52STK240.49252160
53FGR0.47920722
54IGF1R0.47851178
55VRK10.46581175
56ROCK10.46371278
57PLK20.44881926
58OBSCN0.43994728
59MAPK70.40409006
60VRK20.40387377
61RPS6KB10.39002362
62MAPK120.38225140
63ERBB30.37143189
64PIM10.36022592
65INSRR0.35920769
66MAP3K140.34627650
67CHUK0.34475453
68PRKCA0.33668495
69DAPK10.32164962
70CAMK2A0.31819474
71MAPK110.31418433
72WNK40.31141383
73BMPR20.30703146
74PRKCI0.30332349
75ADRBK10.29880871
76PRKCH0.29334454
77MAPK30.25324417
78TYK20.24069445
79PASK0.23961009
80GRK70.23948471
81PAK10.23698692
82MARK30.23662770
83PRKACA0.23016406
84MAPK90.22872678
85JAK10.21961639
86MAP3K50.21953514
87GRK10.21167196
88KIT0.21061515
89MUSK0.20944508
90SRC0.20263754
91PDK10.18546950
92BCR0.18291655
93NTRK20.18047110
94PRKCB0.17830833
95MAP4K20.17338835
96MAP2K60.16706019
97STK100.16699827
98MAPKAPK20.16698262
99PRKACG0.16589003
100CSNK1A10.16551208

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.82029120
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.04933171
3T cell receptor signaling pathway_Homo sapiens_hsa046603.98353176
4Antigen processing and presentation_Homo sapiens_hsa046123.85766246
5Graft-versus-host disease_Homo sapiens_hsa053323.13559972
6Hematopoietic cell lineage_Homo sapiens_hsa046402.91915979
7Autoimmune thyroid disease_Homo sapiens_hsa053202.85166342
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59916746
9Allograft rejection_Homo sapiens_hsa053302.52351774
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40600474
11Measles_Homo sapiens_hsa051622.30325812
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.24413608
13Proteasome_Homo sapiens_hsa030502.24330817
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.06479069
15Type I diabetes mellitus_Homo sapiens_hsa049402.05297132
16Salmonella infection_Homo sapiens_hsa051322.02064018
17Rheumatoid arthritis_Homo sapiens_hsa053231.96243065
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89483844
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75302545
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.69545692
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32832640
22Malaria_Homo sapiens_hsa051441.26035608
23Chemokine signaling pathway_Homo sapiens_hsa040621.25497037
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24024436
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20702800
26Shigellosis_Homo sapiens_hsa051311.16756751
27Osteoclast differentiation_Homo sapiens_hsa043801.12032211
28Viral myocarditis_Homo sapiens_hsa054161.09578122
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07949609
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06317486
31Arginine biosynthesis_Homo sapiens_hsa002200.99011821
32Oxidative phosphorylation_Homo sapiens_hsa001900.96930910
33Parkinsons disease_Homo sapiens_hsa050120.91761465
34Herpes simplex infection_Homo sapiens_hsa051680.89508107
35Systemic lupus erythematosus_Homo sapiens_hsa053220.88066625
36Prion diseases_Homo sapiens_hsa050200.80370428
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79569730
38Selenocompound metabolism_Homo sapiens_hsa004500.78935470
39Staphylococcus aureus infection_Homo sapiens_hsa051500.77961692
40Sulfur metabolism_Homo sapiens_hsa009200.72581995
41Regulation of autophagy_Homo sapiens_hsa041400.71611002
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71485162
43Leishmaniasis_Homo sapiens_hsa051400.69014247
44Alzheimers disease_Homo sapiens_hsa050100.64350025
45Fatty acid elongation_Homo sapiens_hsa000620.62860337
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.61603620
47TNF signaling pathway_Homo sapiens_hsa046680.61111311
48Apoptosis_Homo sapiens_hsa042100.60439633
49Basal transcription factors_Homo sapiens_hsa030220.58734279
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.57753663
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57740815
52Biosynthesis of amino acids_Homo sapiens_hsa012300.56814884
53Caffeine metabolism_Homo sapiens_hsa002320.56687180
54Platelet activation_Homo sapiens_hsa046110.56570746
55African trypanosomiasis_Homo sapiens_hsa051430.54417202
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53354501
57RNA polymerase_Homo sapiens_hsa030200.53153403
58Protein export_Homo sapiens_hsa030600.52657498
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48243028
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48072603
61Nitrogen metabolism_Homo sapiens_hsa009100.47251147
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46791097
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46719949
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44248210
65B cell receptor signaling pathway_Homo sapiens_hsa046620.43469426
66Fanconi anemia pathway_Homo sapiens_hsa034600.40371837
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38032704
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35981608
69Amphetamine addiction_Homo sapiens_hsa050310.34831351
70HTLV-I infection_Homo sapiens_hsa051660.34748520
71Homologous recombination_Homo sapiens_hsa034400.33904597
72Renin-angiotensin system_Homo sapiens_hsa046140.32976167
73Pertussis_Homo sapiens_hsa051330.32937407
74Alcoholism_Homo sapiens_hsa050340.32807619
75Legionellosis_Homo sapiens_hsa051340.29607857
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27362911
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27362610
78Epstein-Barr virus infection_Homo sapiens_hsa051690.26638579
79Cardiac muscle contraction_Homo sapiens_hsa042600.26558755
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26378373
81Linoleic acid metabolism_Homo sapiens_hsa005910.25706381
82Chemical carcinogenesis_Homo sapiens_hsa052040.25095288
83Olfactory transduction_Homo sapiens_hsa047400.24921659
84Influenza A_Homo sapiens_hsa051640.24513685
85Huntingtons disease_Homo sapiens_hsa050160.23564438
86Asthma_Homo sapiens_hsa053100.20460998
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.19718352
88Pentose phosphate pathway_Homo sapiens_hsa000300.17527784
89Endocytosis_Homo sapiens_hsa041440.17286950
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17110097
91Lysosome_Homo sapiens_hsa041420.17017340
92MAPK signaling pathway_Homo sapiens_hsa040100.15397474
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14989278
94Collecting duct acid secretion_Homo sapiens_hsa049660.11970227
95Nucleotide excision repair_Homo sapiens_hsa034200.10837565
96Ovarian steroidogenesis_Homo sapiens_hsa049130.10201794
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10032421
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09812588
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08927253
100Retinol metabolism_Homo sapiens_hsa008300.07752812

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