TRAJ28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.74704315
2cytidine metabolic process (GO:0046087)8.74704315
3cytidine catabolic process (GO:0006216)8.74704315
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.58041896
5T cell migration (GO:0072678)7.21876360
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.20413885
7positive T cell selection (GO:0043368)6.79221509
8negative T cell selection (GO:0043383)6.72966166
9negative regulation of T cell apoptotic process (GO:0070233)6.55826601
10negative regulation of stress fiber assembly (GO:0051497)6.52053038
11DNA deamination (GO:0045006)6.33530421
12positive regulation of tolerance induction (GO:0002645)6.03510886
13positive thymic T cell selection (GO:0045059)5.90215191
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87677593
15regulation of T cell tolerance induction (GO:0002664)5.63797500
16regulation of B cell differentiation (GO:0045577)5.57303592
17negative thymic T cell selection (GO:0045060)5.50739257
18thymic T cell selection (GO:0045061)5.46236673
19proteasome assembly (GO:0043248)5.40583013
20negative regulation of actin filament bundle assembly (GO:0032232)5.06975872
21T cell selection (GO:0045058)5.00447735
22positive regulation of B cell differentiation (GO:0045579)5.00056602
23blood vessel maturation (GO:0001955)4.97362178
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.94235610
25positive regulation of calcium-mediated signaling (GO:0050850)4.85919594
26negative regulation of organelle assembly (GO:1902116)4.79463838
27positive regulation of macrophage differentiation (GO:0045651)4.71179068
28regulation of lymphocyte chemotaxis (GO:1901623)4.63559414
29regulation of tolerance induction (GO:0002643)4.62844033
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60999063
31positive regulation of T cell mediated cytotoxicity (GO:0001916)4.60557051
32regulation of T cell apoptotic process (GO:0070232)4.58783716
33signal complex assembly (GO:0007172)4.55953738
34lymphocyte migration (GO:0072676)4.44369104
35negative regulation by host of viral transcription (GO:0043922)4.42504069
36regulation of T cell mediated cytotoxicity (GO:0001914)4.40820307
37negative regulation of lymphocyte apoptotic process (GO:0070229)4.38688710
38cytolysis (GO:0019835)4.38351370
39positive regulation of gamma-delta T cell activation (GO:0046645)4.34882265
40heart trabecula morphogenesis (GO:0061384)4.27694882
41T cell receptor signaling pathway (GO:0050852)4.18807980
42regulation of B cell receptor signaling pathway (GO:0050855)4.12373108
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05802936
44negative regulation of cell killing (GO:0031342)4.05802936
45positive regulation of interleukin-4 production (GO:0032753)4.02523952
46regulation of gamma-delta T cell differentiation (GO:0045586)3.97846941
47regulation of T cell receptor signaling pathway (GO:0050856)3.93734801
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.92562999
49regulation of alpha-beta T cell proliferation (GO:0046640)3.91929874
50positive regulation of lamellipodium assembly (GO:0010592)3.80428517
51regulation of interleukin-2 biosynthetic process (GO:0045076)3.78153773
52positive regulation of lymphocyte migration (GO:2000403)3.77868885
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.76482894
54immunoglobulin mediated immune response (GO:0016064)3.69706873
55lymphocyte chemotaxis (GO:0048247)3.68080818
56eosinophil chemotaxis (GO:0048245)3.61890693
57negative regulation of viral genome replication (GO:0045071)3.60419322
58regulation of calcium-mediated signaling (GO:0050848)3.59372508
59interferon-gamma production (GO:0032609)3.58990824
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58390707
61macrophage chemotaxis (GO:0048246)3.56700358
62leukocyte aggregation (GO:0070486)3.56510413
63positive regulation of cell killing (GO:0031343)3.55207055
64pyrimidine nucleoside catabolic process (GO:0046135)3.54569766
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49464900
66regulation of gamma-delta T cell activation (GO:0046643)3.48039321
67regulation of isotype switching to IgG isotypes (GO:0048302)3.45657873
68positive regulation of interleukin-2 production (GO:0032743)3.45083132
69negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.45067680
70B cell mediated immunity (GO:0019724)3.40088396
71antigen receptor-mediated signaling pathway (GO:0050851)3.39707533
72regulation of cell killing (GO:0031341)3.39639509
73positive regulation of T cell mediated immunity (GO:0002711)3.38059477
74negative regulation of T cell receptor signaling pathway (GO:0050860)3.37648177
75mucosal-associated lymphoid tissue development (GO:0048537)3.37573075
76Peyers patch development (GO:0048541)3.37573075
77trabecula morphogenesis (GO:0061383)3.37070120
78regulation of defense response to virus by virus (GO:0050690)3.31025035
79regulation of T cell chemotaxis (GO:0010819)3.30445762
80positive regulation of T cell chemotaxis (GO:0010820)3.30445762
81actin nucleation (GO:0045010)3.30234603
82eosinophil migration (GO:0072677)3.29732824
83negative regulation of leukocyte apoptotic process (GO:2000107)3.29518274
84antigen processing and presentation via MHC class Ib (GO:0002475)3.27916507
85axoneme assembly (GO:0035082)3.24363469
86regulation of activation of Janus kinase activity (GO:0010533)3.23320697
87cellular response to interleukin-15 (GO:0071350)3.22512571
88regulation of lymphocyte migration (GO:2000401)3.22055621
89regulation of interleukin-4 production (GO:0032673)3.20102189
90regulation of lymphocyte apoptotic process (GO:0070228)3.19365845
91positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17411799
92positive regulation of granulocyte differentiation (GO:0030854)3.16767679
93positive regulation of natural killer cell mediated immunity (GO:0002717)3.16447631
94regulation of T cell mediated immunity (GO:0002709)3.11644453
95positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.10993601
96regulation of natural killer cell mediated immunity (GO:0002715)3.10061828
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10061828
98dopamine biosynthetic process (GO:0042416)3.08850856
99positive regulation of astrocyte differentiation (GO:0048711)3.03783246
100negative regulation of viral transcription (GO:0032897)3.03433018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.25925839
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.79679486
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.27708391
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90537803
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38507987
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31223528
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10311822
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09794867
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07802416
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02363207
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93849396
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.92503393
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.87658874
14RUNX_20019798_ChIP-Seq_JUKART_Human2.81039037
15MYB_26560356_Chip-Seq_TH2_Human2.76506835
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45027558
17GATA3_27048872_Chip-Seq_THYMUS_Human2.43062708
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.41888566
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12103189
20UTX_26944678_Chip-Seq_JUKART_Human1.98800186
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94664463
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85249071
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.78265809
24MYB_26560356_Chip-Seq_TH1_Human1.73146679
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69233514
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66828674
27HTT_18923047_ChIP-ChIP_STHdh_Human1.66691030
28MAF_26560356_Chip-Seq_TH1_Human1.62673033
29GATA3_26560356_Chip-Seq_TH2_Human1.57271796
30BCL6_27268052_Chip-Seq_Bcells_Human1.52329012
31SCL_19346495_ChIP-Seq_HPC-7_Human1.50332760
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46794797
33MAF_26560356_Chip-Seq_TH2_Human1.45098480
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44656266
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.33676356
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30650838
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26108936
38VDR_23849224_ChIP-Seq_CD4+_Human1.25942107
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25340562
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.24641793
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.22561634
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21047740
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20870336
44RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17656409
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14755236
46SPI1_23547873_ChIP-Seq_NB4_Human1.10459901
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10104893
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09102452
49CTCF_20526341_ChIP-Seq_ESCs_Human1.06806101
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03199465
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00221528
52IRF1_19129219_ChIP-ChIP_H3396_Human1.00160862
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97472181
54BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96284715
55VDR_22108803_ChIP-Seq_LS180_Human0.95911680
56TP53_22573176_ChIP-Seq_HFKS_Human0.95848999
57IRF8_27001747_Chip-Seq_BMDM_Mouse0.95610124
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95603666
59PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94490489
60P300_27268052_Chip-Seq_Bcells_Human0.92302025
61YY1_22570637_ChIP-Seq_MALME-3M_Human0.91991834
62GATA3_21878914_ChIP-Seq_MCF-7_Human0.89527668
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88945297
64MYC_19829295_ChIP-Seq_ESCs_Human0.88609831
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87633410
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87365180
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82245749
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81638992
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80696240
70TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78374372
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78363972
72PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78358512
73FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78276222
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78266597
75VDR_24787735_ChIP-Seq_THP-1_Human0.77121498
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75721350
77TAF2_19829295_ChIP-Seq_ESCs_Human0.75080465
78JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74971840
79SA1_27219007_Chip-Seq_Bcells_Human0.73421398
80RXR_22108803_ChIP-Seq_LS180_Human0.72444037
81GATA3_26560356_Chip-Seq_TH1_Human0.71750172
82NANOG_20526341_ChIP-Seq_ESCs_Human0.70142051
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69969616
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69872142
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69576546
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69018476
87EST1_17652178_ChIP-ChIP_JURKAT_Human0.68141702
88AR_20517297_ChIP-Seq_VCAP_Human0.68019751
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67505134
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.66719271
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.66081829
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66043583
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.65482274
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64969091
95ERA_21632823_ChIP-Seq_H3396_Human0.64966436
96FOXP3_21729870_ChIP-Seq_TREG_Human0.64666224
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64552149
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.63723026
99CEBPB_22108803_ChIP-Seq_LS180_Human0.63598686
100ER_23166858_ChIP-Seq_MCF-7_Human0.63527007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.53718143
2MP0003763_abnormal_thymus_physiology4.77467085
3MP0009333_abnormal_splenocyte_physiolog3.55411382
4MP0005000_abnormal_immune_tolerance3.02950283
5MP0009785_altered_susceptibility_to2.91259369
6MP0006082_CNS_inflammation2.62575958
7MP0001873_stomach_inflammation2.57507068
8MP0001835_abnormal_antigen_presentation2.55299887
9MP0002420_abnormal_adaptive_immunity2.44932977
10MP0002405_respiratory_system_inflammati2.35021003
11MP0001790_abnormal_immune_system2.33267297
12MP0005387_immune_system_phenotype2.33267297
13MP0001800_abnormal_humoral_immune2.32682129
14MP0001819_abnormal_immune_cell2.32576038
15MP0003866_abnormal_defecation2.32468696
16MP0002933_joint_inflammation2.23597362
17MP0002723_abnormal_immune_serum2.23491340
18MP0005025_abnormal_response_to2.22079515
19MP0000716_abnormal_immune_system1.99153862
20MP0002148_abnormal_hypersensitivity_rea1.93066575
21MP0002398_abnormal_bone_marrow1.91862477
22MP0000703_abnormal_thymus_morphology1.89143398
23MP0004947_skin_inflammation1.86700662
24MP0002277_abnormal_respiratory_mucosa1.86478517
25MP0005464_abnormal_platelet_physiology1.79083431
26MP0000685_abnormal_immune_system1.78063621
27MP0003787_abnormal_imprinting1.76318254
28MP0002452_abnormal_antigen_presenting1.73653627
29MP0003880_abnormal_central_pattern1.67460147
30MP0002102_abnormal_ear_morphology1.66513643
31MP0002837_dystrophic_cardiac_calcinosis1.66357786
32MP0003448_altered_tumor_morphology1.66211604
33MP0005646_abnormal_pituitary_gland1.65974008
34MP0003724_increased_susceptibility_to1.60976021
35MP0001661_extended_life_span1.60437871
36MP0010155_abnormal_intestine_physiology1.54391331
37MP0002722_abnormal_immune_system1.53601735
38MP0001919_abnormal_reproductive_system1.49465832
39MP0002166_altered_tumor_susceptibility1.48505764
40MP0003436_decreased_susceptibility_to1.44376861
41MP0005083_abnormal_biliary_tract1.42063911
42MP0002419_abnormal_innate_immunity1.40729014
43MP0002138_abnormal_hepatobiliary_system1.40593827
44MP0002429_abnormal_blood_cell1.39100840
45MP0003878_abnormal_ear_physiology1.39087626
46MP0005377_hearing/vestibular/ear_phenot1.39087626
47MP0000689_abnormal_spleen_morphology1.38632725
48MP0009379_abnormal_foot_pigmentation1.37281916
49MP0001764_abnormal_homeostasis1.35565991
50MP0003646_muscle_fatigue1.35083151
51MP0004147_increased_porphyrin_level1.34418570
52MP0003786_premature_aging1.32624746
53MP0003045_fibrosis1.32039359
54MP0004185_abnormal_adipocyte_glucose1.27294661
55MP0001765_abnormal_ion_homeostasis1.25587061
56MP0001905_abnormal_dopamine_level1.23601872
57MP0001188_hyperpigmentation1.22919424
58MP0001845_abnormal_inflammatory_respons1.20618497
59MP0006054_spinal_hemorrhage1.18560369
60MP0002876_abnormal_thyroid_physiology1.18520880
61MP0003195_calcinosis1.16216179
62MP0003567_abnormal_fetal_cardiomyocyte1.15820300
63MP0001348_abnormal_lacrimal_gland1.13233465
64MP0004381_abnormal_hair_follicle1.12113073
65MP0005075_abnormal_melanosome_morpholog1.11280610
66MP0001243_abnormal_dermal_layer1.08665973
67MP0004742_abnormal_vestibular_system1.06057253
68MP0001984_abnormal_olfaction1.05562024
69MP0006072_abnormal_retinal_apoptosis1.05519227
70MP0003137_abnormal_impulse_conducting1.05080131
71MP0009763_increased_sensitivity_to1.04473297
72MP0002006_tumorigenesis0.98416504
73MP0001853_heart_inflammation0.97157498
74MP0005389_reproductive_system_phenotype0.97006212
75MP0010386_abnormal_urinary_bladder0.96774073
76MP0009643_abnormal_urine_homeostasis0.94213120
77MP0002127_abnormal_cardiovascular_syste0.93329970
78MP0005410_abnormal_fertilization0.90126980
79MP0008469_abnormal_protein_level0.87201659
80MP0005645_abnormal_hypothalamus_physiol0.84802134
81MP0005310_abnormal_salivary_gland0.81388706
82MP0004134_abnormal_chest_morphology0.80527366
83MP0005379_endocrine/exocrine_gland_phen0.77851640
84MP0005636_abnormal_mineral_homeostasis0.77353134
85MP0003690_abnormal_glial_cell0.76148173
86MP0002019_abnormal_tumor_incidence0.73183852
87MP0004264_abnormal_extraembryonic_tissu0.72162172
88MP0002163_abnormal_gland_morphology0.71399775
89MP0002998_abnormal_bone_remodeling0.69801806
90MP0001542_abnormal_bone_strength0.69022365
91MP0008995_early_reproductive_senescence0.66405316
92MP0000920_abnormal_myelination0.66147147
93MP0003879_abnormal_hair_cell0.64553019
94MP0002693_abnormal_pancreas_physiology0.62740183
95MP0002136_abnormal_kidney_physiology0.62277518
96MP0002928_abnormal_bile_duct0.61760172
97MP0005253_abnormal_eye_physiology0.61268865
98MP0003252_abnormal_bile_duct0.61183705
99MP0005551_abnormal_eye_electrophysiolog0.59700350
100MP0001346_abnormal_lacrimal_gland0.59458814

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)8.55632974
2T lymphocytopenia (HP:0005403)5.30463447
3Abnormality of T cell number (HP:0011839)5.13524554
4Elevated erythrocyte sedimentation rate (HP:0003565)4.68629739
5Severe combined immunodeficiency (HP:0004430)4.56919959
6Hypoplasia of the thymus (HP:0000778)4.51520290
7Abnormality of macrophages (HP:0004311)4.37793001
8Hypoproteinemia (HP:0003075)4.26146990
9IgM deficiency (HP:0002850)4.24094111
10Autoimmune hemolytic anemia (HP:0001890)4.07941437
11IgG deficiency (HP:0004315)3.96200513
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.82467988
13Rib fusion (HP:0000902)3.63152846
14Abnormality of eosinophils (HP:0001879)3.62594655
15Combined immunodeficiency (HP:0005387)3.58747552
16Abnormality of T cells (HP:0002843)3.54044700
17Eosinophilia (HP:0001880)3.42307947
18Lymphopenia (HP:0001888)3.38589467
19Anomalous pulmonary venous return (HP:0010772)3.30868598
20Abnormality of cells of the lymphoid lineage (HP:0012140)3.19126071
21Thyroiditis (HP:0100646)3.17585248
22Gastrointestinal infarctions (HP:0005244)3.14686552
23Stomatitis (HP:0010280)3.12821286
24Congenital stationary night blindness (HP:0007642)3.04650369
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.00690590
26Confusion (HP:0001289)3.00544306
27Abnormality of the pulmonary veins (HP:0011718)2.95030445
28Amyotrophic lateral sclerosis (HP:0007354)2.94622676
29Radial bowing (HP:0002986)2.80442297
30Encephalitis (HP:0002383)2.77332111
31Leukocytosis (HP:0001974)2.74757047
32Abnormal rod and cone electroretinograms (HP:0008323)2.69426815
33Recurrent cutaneous fungal infections (HP:0011370)2.65760393
34Chronic mucocutaneous candidiasis (HP:0002728)2.65760393
35Abnormality of alanine metabolism (HP:0010916)2.64104927
36Hyperalaninemia (HP:0003348)2.64104927
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64104927
38Recurrent bacterial skin infections (HP:0005406)2.63581549
39Granulocytopenia (HP:0001913)2.61759490
40Alveolar cell carcinoma (HP:0006519)2.58860647
41Pancytopenia (HP:0001876)2.54165773
42Cutaneous melanoma (HP:0012056)2.53503620
43Methylmalonic aciduria (HP:0012120)2.43773478
44Increased IgM level (HP:0003496)2.42307110
45Panhypogammaglobulinemia (HP:0003139)2.41540169
46Malignant hyperthermia (HP:0002047)2.40643116
47Respiratory distress (HP:0002098)2.39339513
48Gonadal dysgenesis (HP:0000133)2.38890221
49Generalized aminoaciduria (HP:0002909)2.35156990
50Methylmalonic acidemia (HP:0002912)2.34116064
51Hemiplegia (HP:0002301)2.30728831
52Recurrent fungal infections (HP:0002841)2.29514558
53Polydipsia (HP:0001959)2.29413534
54Abnormal drinking behavior (HP:0030082)2.29413534
55Recurrent skin infections (HP:0001581)2.25409559
56Joint swelling (HP:0001386)2.24942600
57Ketosis (HP:0001946)2.24226273
58Lymphoma (HP:0002665)2.23514445
59Recurrent abscess formation (HP:0002722)2.22779792
60Chest pain (HP:0100749)2.22636790
61Abnormal mitochondria in muscle tissue (HP:0008316)2.21996309
62Neoplasm of the tracheobronchial system (HP:0100552)2.20527292
63Acute necrotizing encephalopathy (HP:0006965)2.16960422
64Agammaglobulinemia (HP:0004432)2.16263201
65Fused cervical vertebrae (HP:0002949)2.15962891
66Mitochondrial inheritance (HP:0001427)2.15727046
67Autoimmune thrombocytopenia (HP:0001973)2.11443095
68Attenuation of retinal blood vessels (HP:0007843)2.09829499
69Polyuria (HP:0000103)2.09123117
70Occipital encephalocele (HP:0002085)2.04283285
71Amniotic constriction ring (HP:0009775)2.02322667
72Abnormality of placental membranes (HP:0011409)2.02322667
73Hyperammonemia (HP:0001987)2.01576473
74Popliteal pterygium (HP:0009756)2.00413225
75Spontaneous hematomas (HP:0007420)1.98014380
76Flat occiput (HP:0005469)1.94651638
77Vasculitis (HP:0002633)1.94388162
78Constricted visual fields (HP:0001133)1.94340235
79Hypergammaglobulinemia (HP:0010702)1.93158821
80Meningitis (HP:0001287)1.92816707
81Long clavicles (HP:0000890)1.91677227
82Chronic diarrhea (HP:0002028)1.90848627
83Pustule (HP:0200039)1.90030652
84Mesangial abnormality (HP:0001966)1.88601179
85Cerebellar dysplasia (HP:0007033)1.87240981
86Aplasia of the musculature (HP:0100854)1.86426380
87Abnormality of T cell physiology (HP:0011840)1.86127097
88Pancreatic cysts (HP:0001737)1.84580400
89Recurrent bronchitis (HP:0002837)1.82005771
90Abnormal urine output (HP:0012590)1.81223490
91Recurrent corneal erosions (HP:0000495)1.80866414
92Cerebral edema (HP:0002181)1.80729972
93Hyponatremia (HP:0002902)1.79904708
94Hypophosphatemic rickets (HP:0004912)1.77908016
95Progressive macrocephaly (HP:0004481)1.77518492
96Abnormal number of erythroid precursors (HP:0012131)1.75578260
97Renal Fanconi syndrome (HP:0001994)1.74516174
98Periodontitis (HP:0000704)1.74029911
99Abnormality of the prostate (HP:0008775)1.73929611
100Recurrent viral infections (HP:0004429)1.71977287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.33493998
2TNK24.66771239
3TESK24.47853463
4MAP4K14.29399071
5TXK3.65882863
6BCKDK3.36086514
7ITK3.06547949
8SCYL23.04593580
9CSK2.53528727
10ZAP702.21796033
11FES2.20521700
12TESK12.15050177
13MAP3K112.09532787
14TEC2.03373361
15PRKCQ1.77635372
16MAP2K71.76752745
17VRK21.65261547
18SYK1.63985993
19STK38L1.62441121
20TAOK31.59703914
21GRK61.57228625
22BTK1.55400861
23LCK1.38560732
24MELK1.27142920
25LIMK11.26861654
26BUB11.24187883
27TAOK21.11606748
28BMX1.10697760
29CDK191.10160675
30ADRBK21.09270026
31CSF1R1.06097001
32TYRO30.96444126
33BCR0.96337013
34IRAK40.92456959
35STK240.87341665
36FGR0.87007439
37LYN0.85499541
38AKT30.85137731
39HCK0.84868213
40ERBB30.80998419
41IKBKE0.76977372
42RPS6KA40.76344707
43INSR0.75438185
44PDGFRB0.72312904
45FGFR10.72087292
46PLK40.72031442
47STK380.69887920
48RIPK40.68120035
49AURKA0.66186461
50IKBKB0.65970691
51BRSK10.63047002
52JAK30.60668356
53GRK10.59450935
54VRK10.58677472
55IGF1R0.55512064
56MST40.54606512
57MAPK110.53032664
58FYN0.51446084
59FGFR20.50441486
60OBSCN0.48855795
61CSNK1A10.47231858
62NUAK10.45502406
63CDK30.45050639
64TBK10.42443702
65INSRR0.40412759
66CDC42BPA0.39229762
67ROCK10.39216628
68ADRBK10.37895754
69ATR0.37064678
70PLK20.37028792
71ABL10.36985778
72FRK0.35645598
73PRKCA0.31429444
74MARK30.31023336
75PAK30.30923644
76NTRK20.30667003
77CAMK2A0.30338515
78MAP3K10.28744261
79MAPK150.28058950
80MAPK30.26457970
81MUSK0.26345813
82PINK10.26194785
83MYLK0.25841874
84RPS6KA50.25205528
85IRAK20.24693407
86LRRK20.24623732
87MAPKAPK30.24608787
88CHUK0.23586370
89TIE10.23454747
90GRK70.23414988
91CAMK10.22776726
92PIM10.22668887
93MAP3K30.22501982
94PTK2B0.22440931
95PAK10.22079352
96TAOK10.21958749
97SRC0.21464517
98MAP4K20.20114684
99PRKACA0.20106466
100PRKACG0.19762902

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.26725420
2T cell receptor signaling pathway_Homo sapiens_hsa046604.17507194
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.70846061
4Antigen processing and presentation_Homo sapiens_hsa046123.20841894
5Graft-versus-host disease_Homo sapiens_hsa053323.02896240
6Hematopoietic cell lineage_Homo sapiens_hsa046402.65962509
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45798346
8Autoimmune thyroid disease_Homo sapiens_hsa053202.27951820
9Allograft rejection_Homo sapiens_hsa053302.19733186
10Measles_Homo sapiens_hsa051622.10687219
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.07240648
12Oxidative phosphorylation_Homo sapiens_hsa001902.05639651
13Type I diabetes mellitus_Homo sapiens_hsa049401.77196452
14Salmonella infection_Homo sapiens_hsa051321.61586280
15Proteasome_Homo sapiens_hsa030501.59597899
16Parkinsons disease_Homo sapiens_hsa050121.55270561
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51904268
18Sulfur metabolism_Homo sapiens_hsa009201.51500159
19Malaria_Homo sapiens_hsa051441.46073069
20Rheumatoid arthritis_Homo sapiens_hsa053231.45935618
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45597023
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44618608
23Alzheimers disease_Homo sapiens_hsa050101.40017936
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32357610
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29097155
26Basal transcription factors_Homo sapiens_hsa030221.27241761
27Ribosome_Homo sapiens_hsa030101.22267319
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21546034
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21080034
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20298471
31Viral myocarditis_Homo sapiens_hsa054161.13199261
32Shigellosis_Homo sapiens_hsa051311.10071055
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06776745
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06402592
35Nitrogen metabolism_Homo sapiens_hsa009101.01280094
36Arginine biosynthesis_Homo sapiens_hsa002200.98088496
37Collecting duct acid secretion_Homo sapiens_hsa049660.95151513
38Osteoclast differentiation_Homo sapiens_hsa043800.90724182
39Phototransduction_Homo sapiens_hsa047440.88847728
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88830898
41Chemokine signaling pathway_Homo sapiens_hsa040620.87900042
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86176995
43Huntingtons disease_Homo sapiens_hsa050160.85550789
44Herpes simplex infection_Homo sapiens_hsa051680.81142255
45B cell receptor signaling pathway_Homo sapiens_hsa046620.75915187
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75128042
47Systemic lupus erythematosus_Homo sapiens_hsa053220.73819126
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73073434
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71111729
50Staphylococcus aureus infection_Homo sapiens_hsa051500.70977819
51Protein export_Homo sapiens_hsa030600.68752199
52African trypanosomiasis_Homo sapiens_hsa051430.68654700
53Cardiac muscle contraction_Homo sapiens_hsa042600.67027559
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64444771
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.59846520
56Leishmaniasis_Homo sapiens_hsa051400.57653460
57Butanoate metabolism_Homo sapiens_hsa006500.56601342
58Tryptophan metabolism_Homo sapiens_hsa003800.55726848
59Olfactory transduction_Homo sapiens_hsa047400.55713581
60TNF signaling pathway_Homo sapiens_hsa046680.55697486
61Phenylalanine metabolism_Homo sapiens_hsa003600.53934996
62Caffeine metabolism_Homo sapiens_hsa002320.52315160
63Steroid biosynthesis_Homo sapiens_hsa001000.50128206
64HTLV-I infection_Homo sapiens_hsa051660.49700258
65Apoptosis_Homo sapiens_hsa042100.49273667
66Tyrosine metabolism_Homo sapiens_hsa003500.48950525
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47895137
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.46088664
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43006192
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.41406116
71Amphetamine addiction_Homo sapiens_hsa050310.40423449
72Taste transduction_Homo sapiens_hsa047420.40139151
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.37533384
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36757294
75Propanoate metabolism_Homo sapiens_hsa006400.36588447
76Platelet activation_Homo sapiens_hsa046110.36042659
77Homologous recombination_Homo sapiens_hsa034400.33541806
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32299604
79Alcoholism_Homo sapiens_hsa050340.31396159
80VEGF signaling pathway_Homo sapiens_hsa043700.30205349
81FoxO signaling pathway_Homo sapiens_hsa040680.29461672
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29249175
83Renin secretion_Homo sapiens_hsa049240.29207865
84Chemical carcinogenesis_Homo sapiens_hsa052040.27778932
85Rap1 signaling pathway_Homo sapiens_hsa040150.27045814
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26838793
87Renin-angiotensin system_Homo sapiens_hsa046140.26477257
88MAPK signaling pathway_Homo sapiens_hsa040100.25909830
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24505029
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23869351
91Cholinergic synapse_Homo sapiens_hsa047250.21872710
92Ovarian steroidogenesis_Homo sapiens_hsa049130.18388797
93Phagosome_Homo sapiens_hsa041450.17807806
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17770518
95cAMP signaling pathway_Homo sapiens_hsa040240.17348254
96Selenocompound metabolism_Homo sapiens_hsa004500.17091365
97Pertussis_Homo sapiens_hsa051330.16981650
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16629665
99beta-Alanine metabolism_Homo sapiens_hsa004100.16213525
100Endocytosis_Homo sapiens_hsa041440.15914516

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