TRAJ30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation by host of viral transcription (GO:0043922)6.40973660
2T cell migration (GO:0072678)6.29917264
3cytolysis (GO:0019835)5.68753532
4Arp2/3 complex-mediated actin nucleation (GO:0034314)5.68626905
5pyrimidine nucleoside catabolic process (GO:0046135)5.68012671
6eosinophil chemotaxis (GO:0048245)5.59943035
7negative regulation of viral genome replication (GO:0045071)5.43128377
8negative regulation of T cell apoptotic process (GO:0070233)5.14139311
9eosinophil migration (GO:0072677)5.05711346
10actin nucleation (GO:0045010)4.99675330
11regulation of activation of Janus kinase activity (GO:0010533)4.97828716
12cellular response to interleukin-15 (GO:0071350)4.92043753
13macrophage chemotaxis (GO:0048246)4.71615335
14positive regulation of monocyte chemotaxis (GO:0090026)4.61039962
15positive T cell selection (GO:0043368)4.55761176
16negative T cell selection (GO:0043383)4.47014544
17lymphocyte chemotaxis (GO:0048247)4.45003057
18regulation of lymphocyte chemotaxis (GO:1901623)4.42295082
19positive regulation of gamma-delta T cell activation (GO:0046645)4.38673561
20positive regulation of calcium-mediated signaling (GO:0050850)4.38673556
21positive regulation of T cell chemotaxis (GO:0010820)4.30415368
22regulation of T cell chemotaxis (GO:0010819)4.30415368
23positive regulation of translational initiation (GO:0045948)4.27329412
24sequestering of actin monomers (GO:0042989)4.25463831
25positive thymic T cell selection (GO:0045059)4.24740452
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.21977781
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.20884051
28negative regulation of stress fiber assembly (GO:0051497)4.18707112
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15169947
30positive regulation of interleukin-8 secretion (GO:2000484)4.08322369
31regulation of T cell tolerance induction (GO:0002664)4.01041194
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.00777755
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98581825
34cellular defense response (GO:0006968)3.91988003
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.91227462
36thymic T cell selection (GO:0045061)3.86533966
37response to interleukin-15 (GO:0070672)3.86010997
38positive regulation of tolerance induction (GO:0002645)3.84770326
39regulation of viral genome replication (GO:0045069)3.76779705
40regulation of regulatory T cell differentiation (GO:0045589)3.72776504
41modulation by host of symbiont transcription (GO:0052472)3.71042833
42modulation by host of viral transcription (GO:0043921)3.71042833
43positive regulation of defense response to virus by host (GO:0002230)3.70593243
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.70071510
45regulation of natural killer cell mediated immunity (GO:0002715)3.70071510
46DNA demethylation (GO:0080111)3.69317826
47regulation of B cell receptor signaling pathway (GO:0050855)3.68809973
48lymphocyte migration (GO:0072676)3.67939756
49regulation of chronic inflammatory response (GO:0002676)3.67107390
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.66348619
51regulation of gamma-delta T cell differentiation (GO:0045586)3.66282977
52negative regulation of lymphocyte apoptotic process (GO:0070229)3.66181026
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.65051260
54negative regulation of viral transcription (GO:0032897)3.61981737
55regulation of mononuclear cell migration (GO:0071675)3.58758751
56positive regulation of lymphocyte migration (GO:2000403)3.56900560
57regulation of B cell differentiation (GO:0045577)3.56101597
58T cell costimulation (GO:0031295)3.53457251
59T cell receptor signaling pathway (GO:0050852)3.50928391
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.49522568
61positive regulation of cell killing (GO:0031343)3.49070991
62lymphocyte costimulation (GO:0031294)3.48954718
63modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.48739932
64negative regulation of viral process (GO:0048525)3.47481842
65positive regulation of B cell differentiation (GO:0045579)3.42828818
66regulation of interleukin-2 biosynthetic process (GO:0045076)3.39234583
67negative thymic T cell selection (GO:0045060)3.38676230
68T cell selection (GO:0045058)3.35175041
69regulation of macrophage chemotaxis (GO:0010758)3.32703865
70pyrimidine-containing compound catabolic process (GO:0072529)3.32375744
71regulation of alpha-beta T cell proliferation (GO:0046640)3.26973251
72regulation of calcium-mediated signaling (GO:0050848)3.25841453
73regulation of tolerance induction (GO:0002643)3.21159872
74negative regulation of oxidoreductase activity (GO:0051354)3.20992388
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18970324
76regulation of T cell mediated cytotoxicity (GO:0001914)3.18846005
77positive regulation of interleukin-4 production (GO:0032753)3.17580982
78negative regulation of calcium ion transport into cytosol (GO:0010523)3.15818575
79DNA dealkylation (GO:0035510)3.15064963
80regulation of T cell apoptotic process (GO:0070232)3.14753186
81negative regulation of actin filament bundle assembly (GO:0032232)3.14320589
82regulation of interleukin-12 biosynthetic process (GO:0045075)3.13425960
83dendritic cell chemotaxis (GO:0002407)3.13356687
84regulation of chemokine-mediated signaling pathway (GO:0070099)3.13310886
85chemokine-mediated signaling pathway (GO:0070098)3.13073190
86regulation of cellular amino acid metabolic process (GO:0006521)3.09484484
87regulation of gamma-delta T cell activation (GO:0046643)3.08496370
88regulation of cell killing (GO:0031341)3.07915952
89monocyte chemotaxis (GO:0002548)3.03836725
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02007278
91positive regulation of T cell apoptotic process (GO:0070234)3.01052655
92negative regulation of execution phase of apoptosis (GO:1900118)3.00116256
93antigen receptor-mediated signaling pathway (GO:0050851)2.96605073
94pyrimidine ribonucleoside metabolic process (GO:0046131)2.96542808
95cytidine deamination (GO:0009972)12.9844575
96cytidine metabolic process (GO:0046087)12.9844575
97cytidine catabolic process (GO:0006216)12.9844575
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509112.3868001
99pyrimidine ribonucleoside catabolic process (GO:0046133)11.7984505
100DNA deamination (GO:0045006)10.2295310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.03311013
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.80233672
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.24443696
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.04693339
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88105873
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84521526
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42340069
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32587366
9MYB_26560356_Chip-Seq_TH2_Human3.22007795
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.05581428
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02496215
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.97678208
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89905618
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.58060206
15RUNX_20019798_ChIP-Seq_JUKART_Human2.56798824
16GATA3_27048872_Chip-Seq_THYMUS_Human2.24796003
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21606413
18UTX_26944678_Chip-Seq_JUKART_Human2.15294392
19MYB_26560356_Chip-Seq_TH1_Human2.06071259
20BP1_19119308_ChIP-ChIP_Hs578T_Human10.4630603
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97986084
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90042536
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84121936
24MAF_26560356_Chip-Seq_TH1_Human1.77565600
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74363173
26MAF_26560356_Chip-Seq_TH2_Human1.73515941
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70258812
28GATA3_26560356_Chip-Seq_TH2_Human1.68575421
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65931884
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.52164481
31HTT_18923047_ChIP-ChIP_STHdh_Human1.44402725
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43597891
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39161667
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36130845
35BCL6_27268052_Chip-Seq_Bcells_Human1.35295829
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34938845
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.34487861
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32093064
39VDR_23849224_ChIP-Seq_CD4+_Human1.31427026
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30093841
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.29966736
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29364786
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27822574
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27237862
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24831628
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23545435
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19813407
48VDR_22108803_ChIP-Seq_LS180_Human1.19334986
49SPI1_23547873_ChIP-Seq_NB4_Human1.19065934
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18400425
51TAF2_19829295_ChIP-Seq_ESCs_Human1.17799736
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.16996870
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16609878
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11780458
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08099511
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05795736
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05042205
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.04088238
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03711250
60ERG_20517297_ChIP-Seq_VCAP_Human1.01906668
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99592988
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97849442
63TP53_22573176_ChIP-Seq_HFKS_Human0.96834183
64SRF_21415370_ChIP-Seq_HL-1_Mouse0.94439487
65BCOR_27268052_Chip-Seq_Bcells_Human0.93150750
66CIITA_25753668_ChIP-Seq_RAJI_Human0.91768614
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91705361
68ZNF263_19887448_ChIP-Seq_K562_Human0.90986362
69FOXP3_21729870_ChIP-Seq_TREG_Human0.90421099
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88897564
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88892856
72P300_27268052_Chip-Seq_Bcells_Human0.88436865
73RUNX1_22412390_ChIP-Seq_EML_Mouse0.88411385
74CTCF_20526341_ChIP-Seq_ESCs_Human0.87122393
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86670295
76AR_20517297_ChIP-Seq_VCAP_Human0.86213685
77NANOG_20526341_ChIP-Seq_ESCs_Human0.85870961
78ZNF274_21170338_ChIP-Seq_K562_Hela0.85044837
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83597261
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82656635
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.82547549
82IGF1R_20145208_ChIP-Seq_DFB_Human0.81315990
83GATA3_26560356_Chip-Seq_TH1_Human0.78834933
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.76328188
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76328188
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76267509
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76066229
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.75725733
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74282819
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74131888
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74073836
92RXR_22108803_ChIP-Seq_LS180_Human0.73807538
93SPI1_23127762_ChIP-Seq_K562_Human0.73585610
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.73344698
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.73007541
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71997527
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71945491
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70560927
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70096634
100OCT4_20526341_ChIP-Seq_ESCs_Human0.67736815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.96388620
2MP0009785_altered_susceptibility_to4.42432394
3MP0006082_CNS_inflammation4.16219373
4MP0003763_abnormal_thymus_physiology3.99301151
5MP0009333_abnormal_splenocyte_physiolog3.91847659
6MP0001835_abnormal_antigen_presentation3.49224067
7MP0002166_altered_tumor_susceptibility3.05128229
8MP0003045_fibrosis3.02502467
9MP0005000_abnormal_immune_tolerance2.99735923
10MP0005025_abnormal_response_to2.90675950
11MP0003866_abnormal_defecation2.77215559
12MP0002148_abnormal_hypersensitivity_rea2.69591964
13MP0002420_abnormal_adaptive_immunity2.67323404
14MP0001800_abnormal_humoral_immune2.61388251
15MP0003448_altered_tumor_morphology2.60877649
16MP0001819_abnormal_immune_cell2.56895086
17MP0002723_abnormal_immune_serum2.55253026
18MP0001790_abnormal_immune_system2.36423495
19MP0005387_immune_system_phenotype2.36423495
20MP0002006_tumorigenesis2.31417452
21MP0002405_respiratory_system_inflammati2.10815223
22MP0002398_abnormal_bone_marrow2.04210010
23MP0003436_decreased_susceptibility_to2.01307532
24MP0002452_abnormal_antigen_presenting1.98049127
25MP0000716_abnormal_immune_system1.97810081
26MP0010155_abnormal_intestine_physiology1.89261757
27MP0000703_abnormal_thymus_morphology1.85855208
28MP0002419_abnormal_innate_immunity1.68288699
29MP0001845_abnormal_inflammatory_respons1.67882071
30MP0002722_abnormal_immune_system1.62564444
31MP0000685_abnormal_immune_system1.62354257
32MP0001919_abnormal_reproductive_system1.51709368
33MP0002429_abnormal_blood_cell1.51476712
34MP0009763_increased_sensitivity_to1.47559063
35MP0000689_abnormal_spleen_morphology1.42052046
36MP0005377_hearing/vestibular/ear_phenot1.38758076
37MP0003878_abnormal_ear_physiology1.38758076
38MP0002877_abnormal_melanocyte_morpholog1.35565108
39MP0005464_abnormal_platelet_physiology1.33695777
40MP0001873_stomach_inflammation1.31386064
41MP0000569_abnormal_digit_pigmentation1.29995892
42MP0002876_abnormal_thyroid_physiology1.27523995
43MP0002102_abnormal_ear_morphology1.21890814
44MP0002277_abnormal_respiratory_mucosa1.20931523
45MP0001905_abnormal_dopamine_level1.20684473
46MP0008877_abnormal_DNA_methylation1.19988207
47MP0008469_abnormal_protein_level1.19802235
48MP0005310_abnormal_salivary_gland1.17963011
49MP0004947_skin_inflammation1.17528071
50MP0001485_abnormal_pinna_reflex1.17226138
51MP0002168_other_aberrant_phenotype1.14872441
52MP0003786_premature_aging1.13510382
53MP0005166_decreased_susceptibility_to1.11896082
54MP0002909_abnormal_adrenal_gland1.03282084
55MP0004145_abnormal_muscle_electrophysio0.98599577
56MP0005645_abnormal_hypothalamus_physiol0.93262465
57MP0000372_irregular_coat_pigmentation0.91606876
58MP0008873_increased_physiological_sensi0.88358838
59MP0002019_abnormal_tumor_incidence0.88157420
60MP0004130_abnormal_muscle_cell0.87730861
61MP0010307_abnormal_tumor_latency0.87122232
62MP0002095_abnormal_skin_pigmentation0.85419056
63MP0004742_abnormal_vestibular_system0.85339226
64MP0005389_reproductive_system_phenotype0.84771171
65MP0001529_abnormal_vocalization0.84550658
66MP0001661_extended_life_span0.83610487
67MP0009765_abnormal_xenobiotic_induced0.83052059
68MP0001533_abnormal_skeleton_physiology0.81459195
69MP0000858_altered_metastatic_potential0.80984844
70MP0002933_joint_inflammation0.78077345
71MP0003724_increased_susceptibility_to0.68649964
72MP0002254_reproductive_system_inflammat0.68558313
73MP0003075_altered_response_to0.68388876
74MP0004147_increased_porphyrin_level0.68353864
75MP0000639_abnormal_adrenal_gland0.68331552
76MP0002132_abnormal_respiratory_system0.68203125
77MP0002693_abnormal_pancreas_physiology0.67411752
78MP0000604_amyloidosis0.65754330
79MP0001542_abnormal_bone_strength0.65740924
80MP0004134_abnormal_chest_morphology0.65481575
81MP0001666_abnormal_nutrient_absorption0.65121742
82MP0000920_abnormal_myelination0.64738797
83MP0001853_heart_inflammation0.60302754
84MP0008872_abnormal_physiological_respon0.60248346
85MP0009643_abnormal_urine_homeostasis0.59518300
86MP0008995_early_reproductive_senescence0.58636251
87MP0005623_abnormal_meninges_morphology0.57349263
88MP0002136_abnormal_kidney_physiology0.56939955
89MP0002138_abnormal_hepatobiliary_system0.56146062
90MP0001727_abnormal_embryo_implantation0.55182422
91MP0001968_abnormal_touch/_nociception0.54955031
92MP0004381_abnormal_hair_follicle0.54824173
93MP0006072_abnormal_retinal_apoptosis0.54056529
94MP0005075_abnormal_melanosome_morpholog0.52724071
95MP0002163_abnormal_gland_morphology0.52492896
96MP0002736_abnormal_nociception_after0.51752117
97MP0003137_abnormal_impulse_conducting0.50892630
98MP0005584_abnormal_enzyme/coenzyme_acti0.49767159
99MP0009764_decreased_sensitivity_to0.49351206
100MP0005410_abnormal_fertilization0.47664991

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.20536038
2Abnormality of T cell number (HP:0011839)8.32464406
3Aplastic anemia (HP:0001915)7.79917933
4Abnormality of T cells (HP:0002843)5.34942943
5Hypoproteinemia (HP:0003075)5.07506855
6IgG deficiency (HP:0004315)4.84235981
7Chronic diarrhea (HP:0002028)4.80005221
8Autoimmune hemolytic anemia (HP:0001890)4.68561528
9Severe combined immunodeficiency (HP:0004430)4.41089358
10Increased IgM level (HP:0003496)4.30783239
11Elevated erythrocyte sedimentation rate (HP:0003565)4.12807836
12Recurrent viral infections (HP:0004429)4.09654961
13Abnormality of macrophages (HP:0004311)4.07313696
14Abnormality of eosinophils (HP:0001879)3.69865141
15Thyroiditis (HP:0100646)3.63215418
16Combined immunodeficiency (HP:0005387)3.62332908
17Hypoalbuminemia (HP:0003073)3.58762443
18Abnormal albumin level (HP:0012116)3.58762443
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.57440194
20Encephalitis (HP:0002383)3.51424399
21B lymphocytopenia (HP:0010976)3.41908107
22Chronic mucocutaneous candidiasis (HP:0002728)3.39735879
23Recurrent cutaneous fungal infections (HP:0011370)3.39735879
24Stomatitis (HP:0010280)3.39097130
25Abnormality of B cell number (HP:0010975)3.30808371
26Eosinophilia (HP:0001880)3.30556313
27Lymphopenia (HP:0001888)3.25093157
28Recurrent fungal infections (HP:0002841)3.16176494
29Joint swelling (HP:0001386)3.12537259
30IgM deficiency (HP:0002850)3.05832052
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03790760
32Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03790760
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.03406945
34Leukocytosis (HP:0001974)3.02867310
35Meningitis (HP:0001287)3.02643087
36Hemiplegia (HP:0002301)2.98721226
37Type I transferrin isoform profile (HP:0003642)2.96465450
383-Methylglutaconic aciduria (HP:0003535)2.93962774
39Hepatocellular necrosis (HP:0001404)2.86678434
40Autoimmune thrombocytopenia (HP:0001973)2.86442051
41Increased intramyocellular lipid droplets (HP:0012240)2.72778996
42Acute hepatic failure (HP:0006554)2.71034607
43Amyotrophic lateral sclerosis (HP:0007354)2.71004911
44Mitochondrial inheritance (HP:0001427)2.70086680
45Pustule (HP:0200039)2.69658584
46Granulocytopenia (HP:0001913)2.62889363
47Recurrent bronchitis (HP:0002837)2.58987136
48Lymphoma (HP:0002665)2.57862186
49Pancytopenia (HP:0001876)2.56168406
50Abnormality of the prostate (HP:0008775)2.54763204
51Hypoplasia of the thymus (HP:0000778)2.50989054
52IgA deficiency (HP:0002720)2.50274298
53Renal Fanconi syndrome (HP:0001994)2.43608857
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42868029
55Hepatic necrosis (HP:0002605)2.35199315
56Recurrent abscess formation (HP:0002722)2.33157861
57Abnormality of T cell physiology (HP:0011840)2.31199660
58Myositis (HP:0100614)2.30576927
59Pulmonary infiltrates (HP:0002113)2.20026853
60Hypergammaglobulinemia (HP:0010702)2.19816564
61Increased muscle lipid content (HP:0009058)2.19520586
62Obstructive lung disease (HP:0006536)2.18219296
63Chronic obstructive pulmonary disease (HP:0006510)2.18219296
64Agammaglobulinemia (HP:0004432)2.18061428
65Oral leukoplakia (HP:0002745)2.17775565
66Reduced antithrombin III activity (HP:0001976)2.16636231
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14629821
68Generalized aminoaciduria (HP:0002909)2.14064028
69Tetraplegia (HP:0002445)2.13678512
70Cerebral palsy (HP:0100021)2.12118782
71Abnormal mitochondria in muscle tissue (HP:0008316)2.11079004
72Gastrointestinal infarctions (HP:0005244)2.06845247
73Recurrent skin infections (HP:0001581)2.05506428
74Keratoconjunctivitis (HP:0001096)2.05397792
75Abnormal protein N-linked glycosylation (HP:0012347)2.01038909
76Abnormal protein glycosylation (HP:0012346)2.01038909
77Abnormal glycosylation (HP:0012345)2.01038909
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01038909
79Bronchitis (HP:0012387)1.98063234
80Increased CSF lactate (HP:0002490)1.97226945
81Mediastinal lymphadenopathy (HP:0100721)1.96476909
82Agitation (HP:0000713)1.95128337
83Retrobulbar optic neuritis (HP:0100654)1.94553474
84Optic neuritis (HP:0100653)1.94553474
85Oligomenorrhea (HP:0000876)1.94100923
86Chest pain (HP:0100749)1.93087669
87Hyponatremia (HP:0002902)1.89041883
88Recurrent otitis media (HP:0000403)1.88840677
89Recurrent bacterial skin infections (HP:0005406)1.85734261
90Increased serum ferritin (HP:0003281)1.85554900
91Acute necrotizing encephalopathy (HP:0006965)1.85278322
92Increased CSF protein (HP:0002922)1.85201865
93Gangrene (HP:0100758)1.84939044
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83915177
95Cellular immunodeficiency (HP:0005374)1.83852719
96Panhypogammaglobulinemia (HP:0003139)1.81762007
97Abnormality of the pleura (HP:0002103)1.81347996
98Orchitis (HP:0100796)1.81156110
99Keratoconjunctivitis sicca (HP:0001097)1.76352467
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72907105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.85087169
2TESK26.64534617
3TXK4.69478949
4BCKDK4.36446927
5TESK13.64926680
6MAP4K13.33614964
7ITK3.31873718
8LIMK12.49961352
9GRK62.33055629
10TAOK31.74526865
11PIK3CA1.71342977
12FES1.69313707
13ADRBK21.64003642
14PRKCQ1.63068878
15MAP3K111.62153671
16CSK1.58571416
17SYK1.53940817
18MAPKAPK31.48960653
19BUB11.45432730
20VRK21.45255085
21LCK1.44315396
22MAP4K21.41396121
23TEC1.40939666
24TLK11.39965934
25VRK11.22458990
26IKBKE1.22279718
27GRK71.20920712
28BTK1.13783258
29MAP3K121.12727957
30CAMKK21.11162929
31ZAP701.10276304
32NME11.02319053
33SCYL21.01794278
34BLK0.89084628
35LYN0.87860750
36ZAK0.81515042
37DAPK10.78811780
38GRK10.77750240
39NUAK10.77348116
40DAPK20.77079332
41CLK10.74473899
42IKBKB0.73851355
43TYRO30.70911923
44WNK40.70594807
45FYN0.65387055
46PIK3CG0.63268932
47MAP2K60.60036771
48MAPK110.59797653
49EIF2AK30.56083241
50ROCK10.52974953
51JAK30.51749216
52TBK10.50572873
53MST40.50368555
54MYLK0.49455499
55STK160.48472078
56MAP2K70.48318416
57AURKA0.47161634
58FRK0.43883217
59RPS6KA50.41486464
60CSF1R0.41437229
61LMTK20.39973824
62ACVR1B0.39885030
63MATK0.39256404
64BMPR20.38722286
65PIM10.37636318
66INSR0.37519588
67TIE10.37371620
68CSNK1G30.36757335
69CAMKK10.36434853
70OBSCN0.35883507
71TNK20.32840396
72MAPKAPK20.32351967
73INSRR0.31607500
74IGF1R0.29360367
75STK100.29358164
76MAPK130.28789345
77PRKCA0.28552025
78BRSK20.27614080
79PDK10.27425305
80PRKCB0.26576006
81JAK20.24464727
82GRK50.22370561
83CSNK1A10.21579343
84LRRK20.21544734
85CAMK2A0.20780354
86PAK10.20733963
87CSNK1A1L0.18853967
88PRKACA0.18838802
89NTRK20.18695961
90HCK0.18503879
91ARAF0.18182498
92NTRK10.17879603
93SRC0.17076896
94FGFR10.16983355
95KIT0.15369322
96ATR0.13787861
97AURKB0.13727634
98BRSK10.13269204
99MUSK0.13058517
100RIPK40.12735254

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.11693499
2Proteasome_Homo sapiens_hsa030504.64910171
3Antigen processing and presentation_Homo sapiens_hsa046124.19107872
4Graft-versus-host disease_Homo sapiens_hsa053324.15238866
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.52531939
6Autoimmune thyroid disease_Homo sapiens_hsa053203.41969118
7Allograft rejection_Homo sapiens_hsa053303.31413050
8Hematopoietic cell lineage_Homo sapiens_hsa046402.86815229
9T cell receptor signaling pathway_Homo sapiens_hsa046602.82355800
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63270150
11Type I diabetes mellitus_Homo sapiens_hsa049402.61593941
12Oxidative phosphorylation_Homo sapiens_hsa001902.18157870
13Parkinsons disease_Homo sapiens_hsa050122.05035201
14Rheumatoid arthritis_Homo sapiens_hsa053231.80396100
15Measles_Homo sapiens_hsa051621.75007911
16RNA polymerase_Homo sapiens_hsa030201.73050506
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68593128
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.57432775
19Viral myocarditis_Homo sapiens_hsa054161.55253798
20Salmonella infection_Homo sapiens_hsa051321.50447682
21Shigellosis_Homo sapiens_hsa051311.48322440
22Protein export_Homo sapiens_hsa030601.46484959
23Alzheimers disease_Homo sapiens_hsa050101.44453855
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31695180
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28399526
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23399670
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20158655
28Systemic lupus erythematosus_Homo sapiens_hsa053221.18847592
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11695785
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09293723
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08768611
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08160927
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03266094
34Huntingtons disease_Homo sapiens_hsa050161.00526410
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92422819
36Cardiac muscle contraction_Homo sapiens_hsa042600.89259207
37Prion diseases_Homo sapiens_hsa050200.88228512
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82325168
39Malaria_Homo sapiens_hsa051440.79097128
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77072949
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76531663
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.76041696
43Asthma_Homo sapiens_hsa053100.67522123
44Staphylococcus aureus infection_Homo sapiens_hsa051500.65187067
45Chemokine signaling pathway_Homo sapiens_hsa040620.62773822
46Apoptosis_Homo sapiens_hsa042100.62616146
47Pyrimidine metabolism_Homo sapiens_hsa002400.61619759
48N-Glycan biosynthesis_Homo sapiens_hsa005100.61172699
49Herpes simplex infection_Homo sapiens_hsa051680.60569200
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58264328
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55960460
52Sulfur metabolism_Homo sapiens_hsa009200.53644711
53Epstein-Barr virus infection_Homo sapiens_hsa051690.52415012
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51319719
55Phototransduction_Homo sapiens_hsa047440.50270561
56Leishmaniasis_Homo sapiens_hsa051400.48523840
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.47170745
58Alcoholism_Homo sapiens_hsa050340.45897699
59Pertussis_Homo sapiens_hsa051330.43899092
60Nitrogen metabolism_Homo sapiens_hsa009100.42908950
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.42900542
62Influenza A_Homo sapiens_hsa051640.40247457
63Endocytosis_Homo sapiens_hsa041440.37281762
64Osteoclast differentiation_Homo sapiens_hsa043800.36152712
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32952203
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32383955
67Legionellosis_Homo sapiens_hsa051340.31850446
68Purine metabolism_Homo sapiens_hsa002300.31434300
69Lysosome_Homo sapiens_hsa041420.30762231
70Peroxisome_Homo sapiens_hsa041460.29959901
71TNF signaling pathway_Homo sapiens_hsa046680.29177199
72HTLV-I infection_Homo sapiens_hsa051660.27865778
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27176294
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25814571
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24107030
76Linoleic acid metabolism_Homo sapiens_hsa005910.23691275
77Regulation of autophagy_Homo sapiens_hsa041400.22152743
78African trypanosomiasis_Homo sapiens_hsa051430.21480286
79Retinol metabolism_Homo sapiens_hsa008300.19692436
80Chemical carcinogenesis_Homo sapiens_hsa052040.17423506
81Ribosome_Homo sapiens_hsa030100.16608753
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16514059
83Fanconi anemia pathway_Homo sapiens_hsa034600.16015427
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.15786192
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14521320
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13197259
87Amphetamine addiction_Homo sapiens_hsa050310.13123075
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13046830
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11154269
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10055669
91Viral carcinogenesis_Homo sapiens_hsa052030.09614752
92Propanoate metabolism_Homo sapiens_hsa006400.09130001
93Tuberculosis_Homo sapiens_hsa051520.09105868
94Olfactory transduction_Homo sapiens_hsa047400.07912611
95Steroid biosynthesis_Homo sapiens_hsa001000.07211942
96Selenocompound metabolism_Homo sapiens_hsa004500.06684981
97Collecting duct acid secretion_Homo sapiens_hsa049660.06201201
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06088538
99Phagosome_Homo sapiens_hsa041450.05928342
100Metabolic pathways_Homo sapiens_hsa011000.04731404

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »