TRAJ33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.51413230
2negative regulation of B cell proliferation (GO:0030889)8.37610499
3regulation of regulatory T cell differentiation (GO:0045589)7.54453794
4positive regulation of B cell differentiation (GO:0045579)7.16914220
5positive regulation of interleukin-8 secretion (GO:2000484)6.96487248
6negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.82364215
7intestinal epithelial cell development (GO:0060576)6.38755514
8positive T cell selection (GO:0043368)6.26627120
9pyrimidine nucleoside catabolic process (GO:0046135)6.16491606
10positive thymic T cell selection (GO:0045059)5.76438463
11regulation of B cell receptor signaling pathway (GO:0050855)5.58156964
12positive regulation of gamma-delta T cell activation (GO:0046645)5.50358241
13regulation of B cell differentiation (GO:0045577)5.47249879
14negative regulation of B cell activation (GO:0050869)5.35665404
15regulation of interleukin-8 secretion (GO:2000482)5.24689939
16Arp2/3 complex-mediated actin nucleation (GO:0034314)5.18471932
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13315396
18positive regulation of tolerance induction (GO:0002645)4.96531300
19negative T cell selection (GO:0043383)4.93710919
20regulation of T cell tolerance induction (GO:0002664)4.75789663
21negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.64164754
22maternal placenta development (GO:0001893)4.59369732
23actin nucleation (GO:0045010)4.54216247
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.53631273
25DNA demethylation (GO:0080111)4.48042761
26negative regulation of viral genome replication (GO:0045071)4.43748072
27negative regulation of T cell receptor signaling pathway (GO:0050860)4.35996249
28regulation of gamma-delta T cell activation (GO:0046643)4.31304057
29regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.26348785
30regulation of gamma-delta T cell differentiation (GO:0045586)4.08650237
31thymic T cell selection (GO:0045061)4.07017149
32regulation of T cell receptor signaling pathway (GO:0050856)4.05718085
33regulation of tolerance induction (GO:0002643)4.02852842
34T cell selection (GO:0045058)3.97563581
35activated T cell proliferation (GO:0050798)3.96011722
36positive regulation of lymphocyte migration (GO:2000403)3.91056541
37pyrimidine-containing compound catabolic process (GO:0072529)3.91039760
38T cell receptor signaling pathway (GO:0050852)3.89890742
39negative regulation by host of viral transcription (GO:0043922)3.86469989
40positive regulation of defense response to virus by host (GO:0002230)3.74728647
41positive regulation of interleukin-1 beta secretion (GO:0050718)3.63315930
42DNA dealkylation (GO:0035510)3.61051287
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.60658877
44antigen receptor-mediated signaling pathway (GO:0050851)3.60318141
45negative thymic T cell selection (GO:0045060)3.58346815
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57959773
47negative regulation of cell killing (GO:0031342)3.57959773
48T cell costimulation (GO:0031295)3.54287908
49pyrimidine ribonucleoside metabolic process (GO:0046131)3.52295843
50lymphocyte costimulation (GO:0031294)3.49931054
51trophoblast giant cell differentiation (GO:0060707)3.44863403
52regulation of lymphocyte chemotaxis (GO:1901623)3.44851024
53positive regulation of interleukin-1 secretion (GO:0050716)3.43727723
54regulation of interleukin-1 beta secretion (GO:0050706)3.42306340
55eosinophil chemotaxis (GO:0048245)3.39696620
56negative regulation of T cell apoptotic process (GO:0070233)3.28437904
57positive regulation of antigen processing and presentation (GO:0002579)3.27378688
58positive regulation of chemokine secretion (GO:0090197)3.25397708
59positive regulation of calcium-mediated signaling (GO:0050850)3.23694588
60locomotory exploration behavior (GO:0035641)3.19794557
61regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.16158334
62positive regulation of T cell migration (GO:2000406)3.15619862
63antigen processing and presentation via MHC class Ib (GO:0002475)3.15509067
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.15097868
65B cell receptor signaling pathway (GO:0050853)3.14751750
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.10550878
67macrophage chemotaxis (GO:0048246)3.10464516
68natural killer cell differentiation (GO:0001779)3.10272661
69regulation of viral genome replication (GO:0045069)3.10028712
70eosinophil migration (GO:0072677)3.08404695
71regulation of natural killer cell differentiation (GO:0032823)3.06255940
72cellular response to interleukin-15 (GO:0071350)3.04437275
73regulation of interleukin-1 secretion (GO:0050704)3.04431711
74natural killer cell activation (GO:0030101)3.01860338
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.00762623
76regulation of lymphocyte migration (GO:2000401)3.00712370
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99647745
78chemokine-mediated signaling pathway (GO:0070098)2.99506628
79regulation of T cell mediated cytotoxicity (GO:0001914)2.94681137
80regulation of B cell proliferation (GO:0030888)2.93597453
81response to interferon-beta (GO:0035456)2.92249579
82negative regulation of viral process (GO:0048525)2.91154477
83negative regulation of lymphocyte proliferation (GO:0050672)2.90980329
84negative regulation of mononuclear cell proliferation (GO:0032945)2.90980329
85negative regulation of calcium ion transport into cytosol (GO:0010523)2.90058972
86regulation of natural killer cell mediated immunity (GO:0002715)2.88730386
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88730386
88regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87458800
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80870178
90regulation of activation of Janus kinase activity (GO:0010533)2.80749321
91positive regulation of cell killing (GO:0031343)2.79515613
92regulation of T cell migration (GO:2000404)2.78501500
93negative regulation of leukocyte proliferation (GO:0070664)2.74971634
94regulation of chemokine secretion (GO:0090196)2.71995578
95positive regulation of actin filament polymerization (GO:0030838)2.69625478
96cytidine metabolic process (GO:0046087)13.8827825
97cytidine catabolic process (GO:0006216)13.8827825
98cytidine deamination (GO:0009972)13.8827825
99pyrimidine ribonucleoside catabolic process (GO:0046133)13.1346657
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.3295307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.49986194
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.94965391
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.90584151
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.21424346
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.80560640
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.57631069
7SMAD_19615063_ChIP-ChIP_OVARY_Human4.12731952
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.93706200
9RUNX_20019798_ChIP-Seq_JUKART_Human3.62618603
10MYB_26560356_Chip-Seq_TH2_Human2.87573267
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85045758
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.65811476
13GATA1_22025678_ChIP-Seq_K562_Human2.65243573
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47177904
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43737174
16MYB_26560356_Chip-Seq_TH1_Human2.21104680
17GATA3_27048872_Chip-Seq_THYMUS_Human2.20315954
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19356908
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09549886
20VDR_22108803_ChIP-Seq_LS180_Human1.98658711
21GATA3_26560356_Chip-Seq_TH2_Human1.88047286
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.86008219
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73158547
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69059433
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69059433
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69059433
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64460544
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52360168
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.51000840
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39802324
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39484420
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34152751
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27341248
34MAF_26560356_Chip-Seq_TH2_Human1.25964122
35PRDM14_20953172_ChIP-Seq_ESCs_Human1.23280896
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20603427
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20282364
38TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20168557
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.19867788
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13753958
41MAF_26560356_Chip-Seq_TH1_Human1.10962172
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.10875691
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09480737
44SPI1_23547873_ChIP-Seq_NB4_Human1.09043258
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.08952774
46ER_23166858_ChIP-Seq_MCF-7_Human1.01973462
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00487778
48NANOG_19829295_ChIP-Seq_ESCs_Human1.00199017
49SOX2_19829295_ChIP-Seq_ESCs_Human1.00199017
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99917671
51GABP_17652178_ChIP-ChIP_JURKAT_Human0.98816715
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96301817
53GATA3_26560356_Chip-Seq_TH1_Human0.96049362
54FLI1_27457419_Chip-Seq_LIVER_Mouse0.95674728
55HTT_18923047_ChIP-ChIP_STHdh_Human0.93876830
56AR_20517297_ChIP-Seq_VCAP_Human0.93860523
57UTX_26944678_Chip-Seq_JUKART_Human0.93633801
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92591442
59FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92075946
60PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92008067
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91309026
62NANOG_20526341_ChIP-Seq_ESCs_Human0.90754762
63CIITA_25753668_ChIP-Seq_RAJI_Human0.88800680
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87551859
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86576440
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86319012
67EST1_17652178_ChIP-ChIP_JURKAT_Human0.85581834
68TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84949287
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84326075
70SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82885006
71SMRT_27268052_Chip-Seq_Bcells_Human0.82770158
72OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82683508
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.82545519
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82184107
75MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81847412
76VDR_24787735_ChIP-Seq_THP-1_Human0.80719415
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80345140
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79814483
79VDR_23849224_ChIP-Seq_CD4+_Human0.78627519
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77977848
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.75036101
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74739672
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.74141571
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73615138
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72844379
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.72756726
87EZH2_22144423_ChIP-Seq_EOC_Human0.71924338
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71012031
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69268241
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.68385501
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.67412334
92P300_18555785_Chip-Seq_ESCs_Mouse0.67320344
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67006387
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.66028340
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65736039
96FOXP3_21729870_ChIP-Seq_TREG_Human0.65219292
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65203666
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64762215
99CEBPB_22108803_ChIP-Seq_LS180_Human0.63429478
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.60609208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.26440578
2MP0001873_stomach_inflammation4.61907356
3MP0003763_abnormal_thymus_physiology3.80100920
4MP0001853_heart_inflammation3.71195398
5MP0009333_abnormal_splenocyte_physiolog3.47575616
6MP0001835_abnormal_antigen_presentation3.28156952
7MP0009785_altered_susceptibility_to3.20490131
8MP0005075_abnormal_melanosome_morpholog2.70516079
9MP0005000_abnormal_immune_tolerance2.66362514
10MP0002148_abnormal_hypersensitivity_rea2.65074469
11MP0000372_irregular_coat_pigmentation2.63339469
12MP0001800_abnormal_humoral_immune2.60844143
13MP0001919_abnormal_reproductive_system2.55284952
14MP0002420_abnormal_adaptive_immunity2.47390383
15MP0005025_abnormal_response_to2.43726345
16MP0004381_abnormal_hair_follicle2.40503191
17MP0001819_abnormal_immune_cell2.36199529
18MP0002723_abnormal_immune_serum2.31377019
19MP0002933_joint_inflammation2.26885127
20MP0005310_abnormal_salivary_gland2.26839512
21MP0005387_immune_system_phenotype2.19108630
22MP0001790_abnormal_immune_system2.19108630
23MP0002166_altered_tumor_susceptibility2.11484608
24MP0000703_abnormal_thymus_morphology2.10811218
25MP0002163_abnormal_gland_morphology2.06065025
26MP0003011_delayed_dark_adaptation2.04940954
27MP0000716_abnormal_immune_system2.04134747
28MP0002398_abnormal_bone_marrow2.03100091
29MP0002102_abnormal_ear_morphology2.00753705
30MP0002452_abnormal_antigen_presenting1.97817562
31MP0006054_spinal_hemorrhage1.89753914
32MP0005379_endocrine/exocrine_gland_phen1.76264246
33MP0003866_abnormal_defecation1.75361920
34MP0000689_abnormal_spleen_morphology1.72054715
35MP0002722_abnormal_immune_system1.72036451
36MP0002405_respiratory_system_inflammati1.71499130
37MP0006082_CNS_inflammation1.71161663
38MP0002822_catalepsy1.70704637
39MP0000733_abnormal_muscle_development1.67926799
40MP0009765_abnormal_xenobiotic_induced1.64098920
41MP0005389_reproductive_system_phenotype1.62956623
42MP0000685_abnormal_immune_system1.61566735
43MP0005174_abnormal_tail_pigmentation1.59324153
44MP0002006_tumorigenesis1.53650772
45MP0004947_skin_inflammation1.50581460
46MP0002429_abnormal_blood_cell1.50570220
47MP0002419_abnormal_innate_immunity1.50403827
48MP0001845_abnormal_inflammatory_respons1.45036905
49MP0003448_altered_tumor_morphology1.35222544
50MP0002277_abnormal_respiratory_mucosa1.27875724
51MP0003172_abnormal_lysosome_physiology1.26694261
52MP0010155_abnormal_intestine_physiology1.25719265
53MP0002876_abnormal_thyroid_physiology1.24246916
54MP0000015_abnormal_ear_pigmentation1.22194681
55MP0003724_increased_susceptibility_to1.18280997
56MP0003436_decreased_susceptibility_to1.14153954
57MP0003137_abnormal_impulse_conducting1.13930749
58MP0009764_decreased_sensitivity_to1.13750122
59MP0009763_increased_sensitivity_to1.12497035
60MP0003806_abnormal_nucleotide_metabolis1.06914230
61MP0005464_abnormal_platelet_physiology1.05304593
62MP0003786_premature_aging1.04504828
63MP0008995_early_reproductive_senescence1.03195362
64MP0003880_abnormal_central_pattern1.01741680
65MP0002877_abnormal_melanocyte_morpholog0.98768026
66MP0008469_abnormal_protein_level0.90486641
67MP0010307_abnormal_tumor_latency0.90301879
68MP0002132_abnormal_respiratory_system0.89770770
69MP0009379_abnormal_foot_pigmentation0.86576233
70MP0004130_abnormal_muscle_cell0.82151927
71MP0000604_amyloidosis0.81590246
72MP0002019_abnormal_tumor_incidence0.80755283
73MP0001663_abnormal_digestive_system0.78237258
74MP0001348_abnormal_lacrimal_gland0.77066465
75MP0002095_abnormal_skin_pigmentation0.76624963
76MP0001188_hyperpigmentation0.72754721
77MP0002693_abnormal_pancreas_physiology0.71010148
78MP0008873_increased_physiological_sensi0.69973571
79MP0000613_abnormal_salivary_gland0.67286979
80MP0000371_diluted_coat_color0.66172065
81MP0003567_abnormal_fetal_cardiomyocyte0.65941540
82MP0004185_abnormal_adipocyte_glucose0.60604084
83MP0005253_abnormal_eye_physiology0.60223854
84MP0001533_abnormal_skeleton_physiology0.59926860
85MP0005408_hypopigmentation0.59704329
86MP0004883_abnormal_blood_vessel0.57642328
87MP0003656_abnormal_erythrocyte_physiolo0.57402672
88MP0001984_abnormal_olfaction0.55596431
89MP0000249_abnormal_blood_vessel0.55265406
90MP0002396_abnormal_hematopoietic_system0.53376880
91MP0002136_abnormal_kidney_physiology0.51354470
92MP0008874_decreased_physiological_sensi0.51106715
93MP0003183_abnormal_peptide_metabolism0.50977485
94MP0000858_altered_metastatic_potential0.46732968
95MP0004134_abnormal_chest_morphology0.46184173
96MP0005623_abnormal_meninges_morphology0.43963371
97MP0003329_amyloid_beta_deposits0.43692025
98MP0002736_abnormal_nociception_after0.42484609
99MP0001905_abnormal_dopamine_level0.42263223
100MP0009643_abnormal_urine_homeostasis0.41841011

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)5.76490501
2Aplastic anemia (HP:0001915)5.74443842
3T lymphocytopenia (HP:0005403)5.54252910
4Ureteral stenosis (HP:0000071)5.51851043
5Abnormality of the prostate (HP:0008775)5.50798589
6Abnormality of T cell number (HP:0011839)5.45277056
7Ureteral obstruction (HP:0006000)5.29987193
8Increased IgM level (HP:0003496)4.85198175
9Chest pain (HP:0100749)4.73583671
10Pulmonary infiltrates (HP:0002113)4.66854617
11Gangrene (HP:0100758)4.50963793
12Pulmonary fibrosis (HP:0002206)4.46035659
13Oral leukoplakia (HP:0002745)4.41003796
14Chronic obstructive pulmonary disease (HP:0006510)4.18693742
15Obstructive lung disease (HP:0006536)4.18693742
16Hemoptysis (HP:0002105)4.03408394
17IgG deficiency (HP:0004315)3.98604720
18Elevated erythrocyte sedimentation rate (HP:0003565)3.88691005
19Pulmonary embolism (HP:0002204)3.78530458
20Meningitis (HP:0001287)3.72937249
21Gastrointestinal infarctions (HP:0005244)3.70497812
22Hypoproteinemia (HP:0003075)3.65329236
23Abnormality of male internal genitalia (HP:0000022)3.58862179
24Optic neuritis (HP:0100653)3.50280613
25Retrobulbar optic neuritis (HP:0100654)3.50280613
26Abnormality of the pleura (HP:0002103)3.50125851
27Vasculitis (HP:0002633)3.44669098
28Abnormality of T cells (HP:0002843)3.28376283
29Arterial thrombosis (HP:0004420)3.28020091
30Abnormality of the pericardium (HP:0001697)3.22990428
31Seborrheic dermatitis (HP:0001051)3.09457669
32Abnormality of eosinophils (HP:0001879)3.08361195
33Thrombophlebitis (HP:0004418)3.01378686
34Recurrent skin infections (HP:0001581)3.01204229
35Eosinophilia (HP:0001880)2.94902995
36Severe combined immunodeficiency (HP:0004430)2.94480530
37Glomerulopathy (HP:0100820)2.90695260
38Orchitis (HP:0100796)2.89418016
39Skin rash (HP:0000988)2.85774467
40Abnormality of macrophages (HP:0004311)2.84585571
41Premature graying of hair (HP:0002216)2.84148140
42Thyroiditis (HP:0100646)2.82045200
43Encephalitis (HP:0002383)2.79543039
44Polyneuropathy (HP:0001271)2.78088629
45Epistaxis (HP:0000421)2.77548883
46Myositis (HP:0100614)2.73931092
47Ketoacidosis (HP:0001993)2.69864869
48Restrictive lung disease (HP:0002091)2.68143202
49Mediastinal lymphadenopathy (HP:0100721)2.63202698
50Hematochezia (HP:0002573)2.62609689
51Chronic diarrhea (HP:0002028)2.61037809
52Amaurosis fugax (HP:0100576)2.56748140
53Hypoalbuminemia (HP:0003073)2.52541245
54Abnormal albumin level (HP:0012116)2.52541245
55Amyotrophic lateral sclerosis (HP:0007354)2.52153216
56Recurrent bronchitis (HP:0002837)2.50529198
57Hypoplasia of the thymus (HP:0000778)2.48511478
58Progressive external ophthalmoplegia (HP:0000590)2.47870027
59Leukocytosis (HP:0001974)2.46918988
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.43886555
61Severe visual impairment (HP:0001141)2.42391754
62Keratoconjunctivitis sicca (HP:0001097)2.37929970
63Joint swelling (HP:0001386)2.37361291
64Granulocytopenia (HP:0001913)2.36535297
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.34823963
66Absent hand (HP:0004050)2.34636853
67Lymphopenia (HP:0001888)2.34420001
68Abnormal hair whorl (HP:0010721)2.33873778
69Pancreatitis (HP:0001733)2.31819084
70Recurrent bacterial skin infections (HP:0005406)2.29669527
71Pustule (HP:0200039)2.29070956
72Abnormality of the fingertips (HP:0001211)2.26833587
73Supernumerary bones of the axial skeleton (HP:0009144)2.23145343
74Combined immunodeficiency (HP:0005387)2.22170864
75Gingival bleeding (HP:0000225)2.21560022
76Abnormality of binocular vision (HP:0011514)2.21558432
77Diplopia (HP:0000651)2.21558432
78Paresthesia (HP:0003401)2.20893149
79Keratoconjunctivitis (HP:0001096)2.18942113
80Facial edema (HP:0000282)2.18259291
81Periorbital edema (HP:0100539)2.18212871
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16639830
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16639830
84Hypergammaglobulinemia (HP:0010702)2.15480126
85Alveolar cell carcinoma (HP:0006519)2.10502995
86Vertigo (HP:0002321)2.03694645
87Anorexia (HP:0002039)2.03526838
88Supernumerary ribs (HP:0005815)1.98247980
89IgA deficiency (HP:0002720)1.96778376
90Neoplasm of the tracheobronchial system (HP:0100552)1.95796912
91Recurrent abscess formation (HP:0002722)1.95032942
92Gaze-evoked nystagmus (HP:0000640)1.93094171
93Abnormality of incisor morphology (HP:0011063)1.89768301
94Pigmentary retinal degeneration (HP:0001146)1.89259381
95Retinopathy (HP:0000488)1.89206579
96Diastasis recti (HP:0001540)1.85912145
97Keratitis (HP:0000491)1.85430964
98Lymphoma (HP:0002665)1.84816383
99IgM deficiency (HP:0002850)1.79740665
100Tachypnea (HP:0002789)1.74490878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.67222478
2MST43.13321013
3BMPR1B3.11381435
4RIPK42.52639306
5FES2.48293982
6MAP4K12.27082475
7CSK2.20438759
8TXK12.0964033
9MAP3K131.94788762
10ITK1.82729725
11TLK11.82403925
12TYRO31.73898975
13MAP2K61.48831978
14GRK71.46391155
15CAMKK21.44904821
16SYK1.42502792
17ADRBK21.42302792
18IKBKB1.41717148
19TAOK31.35099867
20LCK1.31344419
21BMPR21.31170585
22GRK61.28004075
23NEK61.16957435
24MATK1.16098307
25PINK11.10897986
26FRK1.07035077
27JAK21.05969813
28PRKCQ0.97292396
29FYN0.95215235
30TESK20.92233558
31IKBKE0.79470164
32LYN0.77253658
33CAMKK10.70028003
34IRAK40.69398913
35OXSR10.67304484
36IGF1R0.66166685
37NUAK10.64677641
38ACVR1B0.64107098
39ERBB20.61382109
40WNK40.60555973
41FGR0.58081156
42MELK0.58015433
43GRK50.54606328
44BTK0.54160397
45TEC0.54067306
46PTK2B0.53973788
47EGFR0.53544005
48NTRK10.48656068
49CSF1R0.46251590
50GRK10.45808349
51DYRK1A0.45644602
52BLK0.44520685
53JAK10.43631890
54HCK0.42854835
55CDK60.42789772
56WNK10.42623303
57JAK30.42450794
58PDGFRB0.41913350
59OBSCN0.41698308
60CHUK0.41355958
61PIM10.40933511
62MAP3K140.40818493
63PASK0.39864212
64TRPM70.39080206
65MAP2K70.37698945
66STK110.36000219
67PIK3CG0.35765824
68MAPKAPK30.34431075
69PAK30.33907081
70STK390.33649185
71CAMK2A0.33335745
72ROCK10.33275848
73VRK10.33077881
74CDK40.30556610
75MAP3K10.30358447
76ZAK0.29367276
77MAP3K70.28929817
78INSR0.26110902
79INSRR0.25712040
80PDK10.24338274
81ABL10.22431770
82PRKACA0.20474239
83KIT0.19038129
84BCKDK0.18636830
85PRKCA0.18634600
86RPS6KA50.17896065
87TIE10.16656799
88PRKCD0.16621644
89PRKACB0.16092766
90MARK30.16083872
91ERBB30.16011547
92MYLK0.15877976
93TAOK10.15515196
94CDK180.14542040
95CDK150.14393141
96TYK20.13999048
97PAK10.13392011
98TBK10.13250400
99MUSK0.13193012
100PLK20.12341553

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.49307167
2Autoimmune thyroid disease_Homo sapiens_hsa053204.28698716
3Graft-versus-host disease_Homo sapiens_hsa053323.77969287
4T cell receptor signaling pathway_Homo sapiens_hsa046603.55063450
5Proteasome_Homo sapiens_hsa030503.54960913
6Hematopoietic cell lineage_Homo sapiens_hsa046403.21663241
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.19378058
8Allograft rejection_Homo sapiens_hsa053302.86575362
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.63879751
10Antigen processing and presentation_Homo sapiens_hsa046122.41036667
11Type I diabetes mellitus_Homo sapiens_hsa049402.26175613
12Rheumatoid arthritis_Homo sapiens_hsa053232.21274694
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.06057047
14Measles_Homo sapiens_hsa051622.01716893
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90876152
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72857374
17Salmonella infection_Homo sapiens_hsa051321.68842594
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67783637
19Shigellosis_Homo sapiens_hsa051311.61135011
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57928202
21Vitamin digestion and absorption_Homo sapiens_hsa049771.55236232
22Chemokine signaling pathway_Homo sapiens_hsa040621.42292949
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39299799
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39203925
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30321063
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26122777
27Oxidative phosphorylation_Homo sapiens_hsa001901.23769239
28Viral myocarditis_Homo sapiens_hsa054161.19240398
29Parkinsons disease_Homo sapiens_hsa050121.13477703
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10212026
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.02580286
32Linoleic acid metabolism_Homo sapiens_hsa005911.01045941
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00800987
34Non-homologous end-joining_Homo sapiens_hsa034500.97220795
35Systemic lupus erythematosus_Homo sapiens_hsa053220.95998473
36Osteoclast differentiation_Homo sapiens_hsa043800.91819050
37Ether lipid metabolism_Homo sapiens_hsa005650.84496330
38Leishmaniasis_Homo sapiens_hsa051400.83206870
39Collecting duct acid secretion_Homo sapiens_hsa049660.82222996
40Legionellosis_Homo sapiens_hsa051340.82060674
41Alzheimers disease_Homo sapiens_hsa050100.81346900
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79766941
43Asthma_Homo sapiens_hsa053100.76697288
44Homologous recombination_Homo sapiens_hsa034400.75134157
45Prion diseases_Homo sapiens_hsa050200.72177191
46Pertussis_Homo sapiens_hsa051330.71643541
47Staphylococcus aureus infection_Homo sapiens_hsa051500.70017693
48Protein export_Homo sapiens_hsa030600.68953490
49Apoptosis_Homo sapiens_hsa042100.67682059
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65367485
51Malaria_Homo sapiens_hsa051440.64719451
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64029448
53TNF signaling pathway_Homo sapiens_hsa046680.61025435
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60297525
55African trypanosomiasis_Homo sapiens_hsa051430.60224131
56Nitrogen metabolism_Homo sapiens_hsa009100.59859778
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59464046
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54587349
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.54360163
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52545153
61Tuberculosis_Homo sapiens_hsa051520.52372817
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.48760701
63B cell receptor signaling pathway_Homo sapiens_hsa046620.48216963
64Phototransduction_Homo sapiens_hsa047440.45787313
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44513738
66Platelet activation_Homo sapiens_hsa046110.43870865
67Olfactory transduction_Homo sapiens_hsa047400.43340389
68Influenza A_Homo sapiens_hsa051640.42315540
69Ras signaling pathway_Homo sapiens_hsa040140.40497139
70Herpes simplex infection_Homo sapiens_hsa051680.38858393
71Peroxisome_Homo sapiens_hsa041460.37506003
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36248352
73VEGF signaling pathway_Homo sapiens_hsa043700.35615951
74Endocytosis_Homo sapiens_hsa041440.35501651
75Serotonergic synapse_Homo sapiens_hsa047260.33262917
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.32896360
77RNA polymerase_Homo sapiens_hsa030200.31825029
78HTLV-I infection_Homo sapiens_hsa051660.31602748
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29995630
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.29068002
81Non-small cell lung cancer_Homo sapiens_hsa052230.28036351
82MAPK signaling pathway_Homo sapiens_hsa040100.27779280
83p53 signaling pathway_Homo sapiens_hsa041150.27620251
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.27573275
85Cardiac muscle contraction_Homo sapiens_hsa042600.25900107
86Huntingtons disease_Homo sapiens_hsa050160.25029423
87Epstein-Barr virus infection_Homo sapiens_hsa051690.24688957
88Toxoplasmosis_Homo sapiens_hsa051450.24362039
89Arachidonic acid metabolism_Homo sapiens_hsa005900.23719275
90Viral carcinogenesis_Homo sapiens_hsa052030.23302852
91Morphine addiction_Homo sapiens_hsa050320.22824744
92Gastric acid secretion_Homo sapiens_hsa049710.19189133
93Hedgehog signaling pathway_Homo sapiens_hsa043400.19021008
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.17531980
95Circadian rhythm_Homo sapiens_hsa047100.17499757
96Retinol metabolism_Homo sapiens_hsa008300.17280808
97Steroid biosynthesis_Homo sapiens_hsa001000.15503663
98Alcoholism_Homo sapiens_hsa050340.15202326
99Chemical carcinogenesis_Homo sapiens_hsa052040.11526177
100MicroRNAs in cancer_Homo sapiens_hsa052060.10639831

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