TRAJ34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)7.25445273
2positive regulation of fatty acid oxidation (GO:0046321)7.01220997
3Arp2/3 complex-mediated actin nucleation (GO:0034314)6.89307650
4positive thymic T cell selection (GO:0045059)6.79138413
5positive regulation of tolerance induction (GO:0002645)6.36644460
6actin nucleation (GO:0045010)6.24358926
7regulation of fatty acid beta-oxidation (GO:0031998)6.17270127
8negative T cell selection (GO:0043383)5.87098877
9regulation of T cell tolerance induction (GO:0002664)5.82061826
10cytidine deamination (GO:0009972)5.57509618
11cytidine metabolic process (GO:0046087)5.57509618
12cytidine catabolic process (GO:0006216)5.57509618
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44013457
14positive regulation of natural killer cell differentiation (GO:0032825)5.43277978
15regulation of memory T cell differentiation (GO:0043380)5.26307143
16regulation of tolerance induction (GO:0002643)5.19990480
17thymic T cell selection (GO:0045061)5.18729818
18negative thymic T cell selection (GO:0045060)5.05438600
19protein neddylation (GO:0045116)5.04580370
20T cell selection (GO:0045058)4.88893325
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.88376218
22pyrimidine ribonucleoside catabolic process (GO:0046133)4.76053654
23regulation of activation of Janus kinase activity (GO:0010533)4.46480301
24positive regulation of lipid catabolic process (GO:0050996)4.44399304
25regulation of ruffle assembly (GO:1900027)4.42559925
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.39285056
27positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.37346721
28positive regulation of interleukin-4 production (GO:0032753)4.32842445
29mucosal-associated lymphoid tissue development (GO:0048537)4.31819476
30Peyers patch development (GO:0048541)4.31819476
31positive regulation of natural killer cell mediated immunity (GO:0002717)4.30281159
32regulation of alpha-beta T cell proliferation (GO:0046640)4.30096990
33respiratory burst (GO:0045730)4.26307644
34positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21284272
35negative regulation of stress fiber assembly (GO:0051497)4.03840142
36cytolysis (GO:0019835)4.03650199
37signal complex assembly (GO:0007172)4.00140931
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.98548591
39negative regulation of viral genome replication (GO:0045071)3.97801957
40positive regulation of calcium-mediated signaling (GO:0050850)3.90779483
41regulation of natural killer cell differentiation (GO:0032823)3.87001101
42negative regulation of oxidoreductase activity (GO:0051354)3.81041574
43regulation of natural killer cell mediated immunity (GO:0002715)3.78004495
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.78004495
45positive regulation of cell killing (GO:0031343)3.71314328
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68118345
47positive regulation of B cell differentiation (GO:0045579)3.66184476
48sequestering of actin monomers (GO:0042989)3.63644586
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58459377
50negative regulation of actin filament bundle assembly (GO:0032232)3.58434269
51regulation of leukocyte mediated cytotoxicity (GO:0001910)3.56911359
52regulation of autophagic vacuole assembly (GO:2000785)3.51427165
53negative regulation of T cell apoptotic process (GO:0070233)3.50644746
54dopamine transport (GO:0015872)3.48123985
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41942751
56type I interferon signaling pathway (GO:0060337)3.38841912
57cellular response to type I interferon (GO:0071357)3.38841912
58T cell migration (GO:0072678)3.38723151
59positive regulation of natural killer cell activation (GO:0032816)3.38513926
60response to type I interferon (GO:0034340)3.36023252
61T cell mediated immunity (GO:0002456)3.33811766
62regulation of viral genome replication (GO:0045069)3.33566423
63regulation of MHC class I biosynthetic process (GO:0045343)3.33291362
64positive regulation of T cell mediated immunity (GO:0002711)3.32834818
65regulation of B cell differentiation (GO:0045577)3.31234290
66regulation of cell killing (GO:0031341)3.29154696
67positive regulation of fatty acid metabolic process (GO:0045923)3.27819157
68regulation of interleukin-2 biosynthetic process (GO:0045076)3.22756398
69regulation of T cell mediated cytotoxicity (GO:0001914)3.18317281
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17317744
71negative regulation of cell killing (GO:0031342)3.17317744
72regulation of fatty acid oxidation (GO:0046320)3.14776981
73negative regulation of nitric-oxide synthase activity (GO:0051001)3.13897189
74regulation of vacuole organization (GO:0044088)3.13177723
75ATP synthesis coupled proton transport (GO:0015986)3.12759774
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12759774
77negative regulation by host of viral transcription (GO:0043922)3.12430594
78peptidyl-arginine omega-N-methylation (GO:0035247)3.10475712
79negative regulation of monooxygenase activity (GO:0032769)3.09885741
80positive regulation of gamma-delta T cell activation (GO:0046645)3.04555976
81interferon-gamma production (GO:0032609)3.04512127
82T cell receptor signaling pathway (GO:0050852)3.03418758
83response to interferon-beta (GO:0035456)3.03173792
84regulation of interleukin-13 production (GO:0032656)3.03050594
85purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.02327077
86regulation of interleukin-4 production (GO:0032673)3.01067975
87cellular ketone body metabolic process (GO:0046950)2.97335188
88cellular response to reactive nitrogen species (GO:1902170)2.96090656
89positive regulation of lymphocyte mediated immunity (GO:0002708)2.94374151
90regulation of calcium-mediated signaling (GO:0050848)2.87530128
91centrosome localization (GO:0051642)2.86222314
92metallo-sulfur cluster assembly (GO:0031163)2.84418071
93iron-sulfur cluster assembly (GO:0016226)2.84418071
94positive regulation of actin filament polymerization (GO:0030838)2.82570455
95cellular response to interleukin-15 (GO:0071350)2.82073355
96T cell costimulation (GO:0031295)2.79734186
97response to interleukin-15 (GO:0070672)2.78357108
98lymphocyte costimulation (GO:0031294)2.76756128
99positive regulation of interleukin-17 production (GO:0032740)2.76574600
100positive regulation of fatty acid beta-oxidation (GO:0032000)10.5223374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.38810368
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.96028883
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89423374
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.68483156
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.61739922
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.63179522
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21719718
8MYB_26560356_Chip-Seq_TH2_Human3.17229654
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06260027
10RUNX_20019798_ChIP-Seq_JUKART_Human2.89538526
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88629677
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83449303
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83435915
14MYB_26560356_Chip-Seq_TH1_Human2.50116907
15GATA3_27048872_Chip-Seq_THYMUS_Human2.45345299
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42131376
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39332074
18HTT_18923047_ChIP-ChIP_STHdh_Human2.29714900
19GATA3_26560356_Chip-Seq_TH2_Human2.19097876
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16589397
21UTX_26944678_Chip-Seq_JUKART_Human2.16268705
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14491965
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02587012
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96680627
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94271827
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72402944
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.71058325
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70735241
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62785458
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57483935
31GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.55037666
32VDR_22108803_ChIP-Seq_LS180_Human1.53459828
33IGF1R_20145208_ChIP-Seq_DFB_Human1.49659239
34SPI1_23547873_ChIP-Seq_NB4_Human1.47323567
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.45531034
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45201453
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44504573
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40052854
39TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.39990285
40MAF_26560356_Chip-Seq_TH1_Human1.37190218
41RXR_22108803_ChIP-Seq_LS180_Human1.32738997
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29347110
43VDR_24787735_ChIP-Seq_THP-1_Human1.23488015
44VDR_23849224_ChIP-Seq_CD4+_Human1.21519487
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20563747
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17328230
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16641193
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.15462575
49CBP_20019798_ChIP-Seq_JUKART_Human1.14610688
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14610688
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12496496
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11430804
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09796596
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07796036
55NANOG_20526341_ChIP-Seq_ESCs_Human1.04360838
56TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04267865
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.02884153
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01145573
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.01145573
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99324307
61BP1_19119308_ChIP-ChIP_Hs578T_Human0.98424225
62NANOG_19829295_ChIP-Seq_ESCs_Human0.98253459
63SOX2_19829295_ChIP-Seq_ESCs_Human0.98253459
64CRX_20693478_ChIP-Seq_RETINA_Mouse0.98038540
65OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96446122
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96374235
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96207635
68PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95142836
69FOXH1_21741376_ChIP-Seq_EPCs_Human0.94635017
70MYC_19829295_ChIP-Seq_ESCs_Human0.92578298
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90965198
72POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90936186
73ERG_20517297_ChIP-Seq_VCAP_Human0.90918239
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89840595
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88540889
76ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88444916
77SPI1_23127762_ChIP-Seq_K562_Human0.86901441
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.86831735
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86339954
80SMAD3_21741376_ChIP-Seq_EPCs_Human0.86246203
81NCOR_22424771_ChIP-Seq_293T_Human0.85181661
82CBX2_27304074_Chip-Seq_ESCs_Mouse0.85085044
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84898239
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84146112
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83459279
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81508522
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78860634
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78218578
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78160046
90STAT1_20625510_ChIP-Seq_HELA_Human0.77897048
91MAF_26560356_Chip-Seq_TH2_Human0.77567288
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77440810
93EGR1_19032775_ChIP-ChIP_M12_Human0.77242563
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76882157
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75717634
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75605075
97TP53_22573176_ChIP-Seq_HFKS_Human0.75599050
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75067521
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74282825
100AR_20517297_ChIP-Seq_VCAP_Human0.74273121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.20021601
2MP0009333_abnormal_splenocyte_physiolog3.60499588
3MP0000569_abnormal_digit_pigmentation3.59553387
4MP0005645_abnormal_hypothalamus_physiol3.52984179
5MP0009785_altered_susceptibility_to3.47497914
6MP0003646_muscle_fatigue3.45011589
7MP0002166_altered_tumor_susceptibility2.85184373
8MP0001835_abnormal_antigen_presentation2.80235937
9MP0001800_abnormal_humoral_immune2.79912059
10MP0005000_abnormal_immune_tolerance2.74060905
11MP0003763_abnormal_thymus_physiology2.72339476
12MP0005174_abnormal_tail_pigmentation2.58766104
13MP0005025_abnormal_response_to2.47134203
14MP0002420_abnormal_adaptive_immunity2.34776425
15MP0001819_abnormal_immune_cell2.28464995
16MP0009764_decreased_sensitivity_to2.21241692
17MP0005387_immune_system_phenotype2.20098342
18MP0001790_abnormal_immune_system2.20098342
19MP0002723_abnormal_immune_serum2.19133241
20MP0001188_hyperpigmentation2.07794425
21MP0005083_abnormal_biliary_tract2.07586610
22MP0004947_skin_inflammation2.04556560
23MP0005075_abnormal_melanosome_morpholog2.03052784
24MP0003045_fibrosis1.94743787
25MP0002452_abnormal_antigen_presenting1.92108050
26MP0002006_tumorigenesis1.91759128
27MP0005084_abnormal_gallbladder_morpholo1.90011661
28MP0003724_increased_susceptibility_to1.85849643
29MP0000716_abnormal_immune_system1.80674699
30MP0000685_abnormal_immune_system1.77347010
31MP0001873_stomach_inflammation1.71487371
32MP0005166_decreased_susceptibility_to1.70566608
33MP0000015_abnormal_ear_pigmentation1.70269322
34MP0000703_abnormal_thymus_morphology1.69550856
35MP0002398_abnormal_bone_marrow1.66559201
36MP0010155_abnormal_intestine_physiology1.64837452
37MP0003136_yellow_coat_color1.64653188
38MP0002933_joint_inflammation1.60256065
39MP0002148_abnormal_hypersensitivity_rea1.59690162
40MP0009379_abnormal_foot_pigmentation1.59176553
41MP0004883_abnormal_blood_vessel1.59037263
42MP0001919_abnormal_reproductive_system1.54720036
43MP0000858_altered_metastatic_potential1.54364216
44MP0004130_abnormal_muscle_cell1.51393288
45MP0004381_abnormal_hair_follicle1.49108661
46MP0002419_abnormal_innate_immunity1.49062254
47MP0005389_reproductive_system_phenotype1.46160977
48MP0001905_abnormal_dopamine_level1.42965307
49MP0003448_altered_tumor_morphology1.41283962
50MP0002722_abnormal_immune_system1.40480968
51MP0002102_abnormal_ear_morphology1.36000148
52MP0006082_CNS_inflammation1.34278000
53MP0000372_irregular_coat_pigmentation1.33271661
54MP0001986_abnormal_taste_sensitivity1.32161510
55MP0002429_abnormal_blood_cell1.29983778
56MP0005464_abnormal_platelet_physiology1.29005365
57MP0009763_increased_sensitivity_to1.28775727
58MP0003436_decreased_susceptibility_to1.26695653
59MP0001845_abnormal_inflammatory_respons1.26308293
60MP0002837_dystrophic_cardiac_calcinosis1.26223185
61MP0003866_abnormal_defecation1.21599054
62MP0000689_abnormal_spleen_morphology1.21395691
63MP0002638_abnormal_pupillary_reflex1.17627277
64MP0002160_abnormal_reproductive_system1.16280025
65MP0002132_abnormal_respiratory_system1.16272512
66MP0005646_abnormal_pituitary_gland1.14680589
67MP0003075_altered_response_to1.10212499
68MP0002019_abnormal_tumor_incidence1.06839467
69MP0001968_abnormal_touch/_nociception1.04713512
70MP0004484_altered_response_of1.03844773
71MP0008995_early_reproductive_senescence1.02867481
72MP0002095_abnormal_skin_pigmentation1.00140310
73MP0002405_respiratory_system_inflammati1.00070133
74MP0008872_abnormal_physiological_respon1.00030055
75MP0000537_abnormal_urethra_morphology0.99921852
76MP0005670_abnormal_white_adipose0.97403025
77MP0003938_abnormal_ear_development0.93847615
78MP0002168_other_aberrant_phenotype0.86862176
79MP0008469_abnormal_protein_level0.85872411
80MP0002138_abnormal_hepatobiliary_system0.85776122
81MP0005423_abnormal_somatic_nervous0.85228111
82MP0004043_abnormal_pH_regulation0.79225179
83MP0004134_abnormal_chest_morphology0.78609837
84MP0009765_abnormal_xenobiotic_induced0.77970898
85MP0001533_abnormal_skeleton_physiology0.74973612
86MP0002736_abnormal_nociception_after0.74144454
87MP0003880_abnormal_central_pattern0.71074768
88MP0003950_abnormal_plasma_membrane0.70767010
89MP0000470_abnormal_stomach_morphology0.64088328
90MP0003633_abnormal_nervous_system0.63624281
91MP0002272_abnormal_nervous_system0.63279862
92MP0000538_abnormal_urinary_bladder0.61775649
93MP0002693_abnormal_pancreas_physiology0.58770063
94MP0008873_increased_physiological_sensi0.57866137
95MP0008877_abnormal_DNA_methylation0.57144549
96MP0008961_abnormal_basal_metabolism0.55871642
97MP0003172_abnormal_lysosome_physiology0.52942398
98MP0000249_abnormal_blood_vessel0.50157449
99MP0003195_calcinosis0.48557411
100MP0003806_abnormal_nucleotide_metabolis0.47988109

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.49339307
2Autoimmune hemolytic anemia (HP:0001890)5.17672789
3T lymphocytopenia (HP:0005403)5.06249548
4Increased IgM level (HP:0003496)5.04087927
5Elevated erythrocyte sedimentation rate (HP:0003565)4.60284622
6Recurrent gram-negative bacterial infections (HP:0005420)4.51254193
7Severe visual impairment (HP:0001141)4.46686321
8Abnormality of T cell number (HP:0011839)4.41034419
9Severe combined immunodeficiency (HP:0004430)4.37898637
10Decreased central vision (HP:0007663)4.31565380
11Increased intramyocellular lipid droplets (HP:0012240)4.16211980
12Respiratory difficulties (HP:0002880)4.01922704
13Recurrent bronchitis (HP:0002837)3.90950731
14Hyperglycinemia (HP:0002154)3.68020311
15Increased hepatocellular lipid droplets (HP:0006565)3.64803488
16Increased muscle lipid content (HP:0009058)3.59850995
17Thyroiditis (HP:0100646)3.57448799
18Congenital stationary night blindness (HP:0007642)3.54941094
19Combined immunodeficiency (HP:0005387)3.47201690
20Renal Fanconi syndrome (HP:0001994)3.40977192
21Lipid accumulation in hepatocytes (HP:0006561)3.40846052
22B lymphocytopenia (HP:0010976)3.38893889
23Eosinophilia (HP:0001880)3.29326830
24Hematochezia (HP:0002573)3.29223047
25Abnormality of B cell number (HP:0010975)3.27210221
26Abnormality of eosinophils (HP:0001879)3.19293962
27Acute hepatic failure (HP:0006554)3.16266058
28Chronic sinusitis (HP:0011109)3.03461346
29Exertional dyspnea (HP:0002875)2.99045725
30Hypergammaglobulinemia (HP:0010702)2.96859631
31Encephalitis (HP:0002383)2.92878487
32Hypoproteinemia (HP:0003075)2.80921756
33Conical tooth (HP:0000698)2.73964967
34Lymphopenia (HP:0001888)2.73726494
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65733601
36Abnormality of DNA repair (HP:0003254)2.54506318
37Leukocytosis (HP:0001974)2.53340870
38Amyotrophic lateral sclerosis (HP:0007354)2.50327135
39Nemaline bodies (HP:0003798)2.50063201
40Granulocytopenia (HP:0001913)2.45842472
41Thick nail (HP:0001805)2.45837750
42Erythema (HP:0010783)2.45819802
43Reduced subcutaneous adipose tissue (HP:0003758)2.45231322
44Abnormal rod and cone electroretinograms (HP:0008323)2.42665068
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.40537039
46Eczematoid dermatitis (HP:0000976)2.36633370
47Mesangial abnormality (HP:0001966)2.34815839
48Recurrent otitis media (HP:0000403)2.34667095
49Rhabdomyolysis (HP:0003201)2.32340119
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31197940
51Dicarboxylic aciduria (HP:0003215)2.31197940
52Abnormality of T cells (HP:0002843)2.29572501
53Recurrent bacterial skin infections (HP:0005406)2.28769795
54Gingival bleeding (HP:0000225)2.27818000
55Abnormality of the columella (HP:0009929)2.24624816
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22454281
57Palpebral edema (HP:0100540)2.17146958
58Inflammation of the large intestine (HP:0002037)2.16383723
59Hyperalaninemia (HP:0003348)2.15427796
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15427796
61Abnormality of alanine metabolism (HP:0010916)2.15427796
62Bronchitis (HP:0012387)2.14144917
63Mitochondrial inheritance (HP:0001427)2.12986393
64Supernumerary bones of the axial skeleton (HP:0009144)2.10399926
65Prostate neoplasm (HP:0100787)2.09187649
66Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08844373
67Nasal polyposis (HP:0100582)2.08691583
68Limb hypertonia (HP:0002509)2.08488390
69Atrioventricular block (HP:0001678)2.07554475
70Abnormality of the fingertips (HP:0001211)2.06200482
71Spontaneous hematomas (HP:0007420)2.04364533
72IgA deficiency (HP:0002720)2.02658815
73Hyperglycinuria (HP:0003108)2.02177096
74Abnormality of renal resorption (HP:0011038)2.01385583
75Facial diplegia (HP:0001349)2.01220284
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98843348
77Recurrent abscess formation (HP:0002722)1.98246994
78Abnormality of serum amino acid levels (HP:0003112)1.97735550
79Hyperphosphaturia (HP:0003109)1.97327633
80Pancytopenia (HP:0001876)1.94511713
81Stomatitis (HP:0010280)1.93826782
82Acute encephalopathy (HP:0006846)1.91843423
83Hyperammonemia (HP:0001987)1.91573707
84Alveolar cell carcinoma (HP:0006519)1.90662055
85Gastrointestinal inflammation (HP:0004386)1.89898826
86Ventricular tachycardia (HP:0004756)1.89896164
87Recurrent fungal infections (HP:0002841)1.88982472
88Meningitis (HP:0001287)1.85892257
89Long nose (HP:0003189)1.84826120
90Muscle fiber inclusion bodies (HP:0100299)1.84823951
91Increased CSF lactate (HP:0002490)1.84765123
92Hepatocellular necrosis (HP:0001404)1.83238835
93Clubbing of toes (HP:0100760)1.82557704
94IgM deficiency (HP:0002850)1.81595843
95Chronic diarrhea (HP:0002028)1.80240073
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79775578
97Glucose intolerance (HP:0000833)1.79732980
98Verrucae (HP:0200043)1.78357136
99Papilloma (HP:0012740)1.78357136
100Hepatic necrosis (HP:0002605)1.78088295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.97586559
2MAP3K104.69987675
3TESK24.05977607
4TXK3.81370062
5VRK23.33529882
6MAP4K12.97385765
7PIK3CA2.33964180
8ADRBK21.98315506
9LRRK21.84903799
10ITK1.78779067
11RIPK41.78546498
12BCKDK1.77862267
13AKT31.63475607
14VRK11.60723950
15TESK11.59763002
16GRK11.53661731
17ZAK1.48762023
18PIM11.43189999
19BTK1.42962513
20IKBKE1.42339414
21GRK61.40963951
22GRK71.40684840
23FRK1.35238396
24TYK21.31114146
25MAP3K51.28845595
26PDK21.28594451
27PRKCQ1.27189692
28PINK11.24433878
29TLK11.23124159
30CAMKK21.23114246
31SYK1.18201730
32RPS6KA51.17502900
33MAP3K121.17102530
34CSK1.16430151
35BUB11.12820312
36ROCK11.11991793
37NLK1.09547168
38ZAP701.08762128
39IKBKB1.07133600
40PIM21.06480127
41JAK11.06068076
42JAK31.04624969
43TEC1.00816727
44NEK91.00538126
45BLK0.93352833
46LYN0.90676556
47EPHB20.90483773
48RPS6KA40.89627043
49NEK60.87033713
50CSF1R0.84047170
51ARAF0.80888682
52LCK0.79580818
53MYLK0.78199478
54KIT0.77076228
55PDK10.76107488
56BMPR20.76039710
57ILK0.71358819
58ERBB20.70605344
59LIMK10.69762869
60SCYL20.68055811
61BRAF0.65388696
62FES0.63328838
63PRPF4B0.62845543
64SGK20.61324965
65TRIB30.61298389
66TBK10.61058771
67TIE10.60490767
68PKN20.58601320
69HCK0.53870437
70MAP3K110.51749677
71ICK0.51584361
72OBSCN0.51267180
73ADRBK10.50588863
74STK100.50396471
75INSRR0.49709112
76FYN0.48067677
77NUAK10.47064472
78GRK50.47005225
79MAPK130.45065844
80JAK20.44652439
81PAK10.42749622
82IGF1R0.38708016
83PRKD10.36654026
84SGK30.35327268
85PTK2B0.32176572
86CAMK2G0.31115681
87CAMKK10.30726189
88MELK0.29732027
89CDK30.28056422
90CSNK1D0.27965183
91INSR0.27593791
92LATS10.26762722
93PIK3CG0.26668745
94ABL10.25572997
95PRKCA0.25392822
96CAMK10.25301186
97MUSK0.24549417
98EGFR0.23020180
99MAP4K20.22723415
100PLK10.22689680

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.60353220
2Proteasome_Homo sapiens_hsa030503.70791111
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.04223959
4Parkinsons disease_Homo sapiens_hsa050122.78785006
5Malaria_Homo sapiens_hsa051442.78161521
6Oxidative phosphorylation_Homo sapiens_hsa001902.74753731
7Hematopoietic cell lineage_Homo sapiens_hsa046402.73033554
8T cell receptor signaling pathway_Homo sapiens_hsa046602.55687846
9ABC transporters_Homo sapiens_hsa020102.45632225
10Antigen processing and presentation_Homo sapiens_hsa046122.34135658
11Graft-versus-host disease_Homo sapiens_hsa053322.16402733
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07161605
13Measles_Homo sapiens_hsa051622.05957886
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83157875
15Ribosome_Homo sapiens_hsa030101.79541621
16Alzheimers disease_Homo sapiens_hsa050101.76757587
17Allograft rejection_Homo sapiens_hsa053301.73450970
18Autoimmune thyroid disease_Homo sapiens_hsa053201.71519101
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68944559
20Peroxisome_Homo sapiens_hsa041461.66615399
21Type I diabetes mellitus_Homo sapiens_hsa049401.57328921
22Shigellosis_Homo sapiens_hsa051311.51798850
23Butanoate metabolism_Homo sapiens_hsa006501.42829827
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39596877
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32735200
26Cardiac muscle contraction_Homo sapiens_hsa042601.32679684
27Huntingtons disease_Homo sapiens_hsa050161.30789288
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28710961
29Caffeine metabolism_Homo sapiens_hsa002321.24332774
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.11450575
31Salmonella infection_Homo sapiens_hsa051321.10275997
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.09189292
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.07263494
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06383982
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03713092
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03626739
37RNA degradation_Homo sapiens_hsa030181.03203948
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02978292
39Phototransduction_Homo sapiens_hsa047441.02610474
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00963517
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98021880
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97855270
43Homologous recombination_Homo sapiens_hsa034400.96109039
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94808090
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93764692
46Nitrogen metabolism_Homo sapiens_hsa009100.90896787
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89754336
48Retinol metabolism_Homo sapiens_hsa008300.88757004
49Pertussis_Homo sapiens_hsa051330.85868660
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85608265
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85595654
52Rheumatoid arthritis_Homo sapiens_hsa053230.83968663
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81297685
54B cell receptor signaling pathway_Homo sapiens_hsa046620.78141084
55Legionellosis_Homo sapiens_hsa051340.76681776
56Leishmaniasis_Homo sapiens_hsa051400.76443931
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.74699749
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69506882
59Propanoate metabolism_Homo sapiens_hsa006400.69200450
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.65348107
61Sulfur relay system_Homo sapiens_hsa041220.64527662
62Staphylococcus aureus infection_Homo sapiens_hsa051500.62674490
63Olfactory transduction_Homo sapiens_hsa047400.61777423
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60858459
65Starch and sucrose metabolism_Homo sapiens_hsa005000.57433898
66Systemic lupus erythematosus_Homo sapiens_hsa053220.57317459
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55726419
68Taste transduction_Homo sapiens_hsa047420.55399001
69Platelet activation_Homo sapiens_hsa046110.54577363
70Asthma_Homo sapiens_hsa053100.50548153
71Viral myocarditis_Homo sapiens_hsa054160.50106458
72Chemokine signaling pathway_Homo sapiens_hsa040620.48083898
73Influenza A_Homo sapiens_hsa051640.41050916
74Herpes simplex infection_Homo sapiens_hsa051680.40597339
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.38988518
76Osteoclast differentiation_Homo sapiens_hsa043800.37033566
77Endocytosis_Homo sapiens_hsa041440.36313050
78HTLV-I infection_Homo sapiens_hsa051660.34599904
79Ras signaling pathway_Homo sapiens_hsa040140.31115562
80Renin-angiotensin system_Homo sapiens_hsa046140.30329102
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.30247379
82Fanconi anemia pathway_Homo sapiens_hsa034600.30064793
83Nucleotide excision repair_Homo sapiens_hsa034200.29657586
84Apoptosis_Homo sapiens_hsa042100.29187724
85Viral carcinogenesis_Homo sapiens_hsa052030.29127166
86Acute myeloid leukemia_Homo sapiens_hsa052210.28529393
87Tuberculosis_Homo sapiens_hsa051520.26825971
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24510883
89TNF signaling pathway_Homo sapiens_hsa046680.23521825
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23303044
91Nicotine addiction_Homo sapiens_hsa050330.23066026
92Toxoplasmosis_Homo sapiens_hsa051450.20451136
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19876136
94Calcium signaling pathway_Homo sapiens_hsa040200.18651095
95Phagosome_Homo sapiens_hsa041450.16692047
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14709287
97Amphetamine addiction_Homo sapiens_hsa050310.13042015
98Epstein-Barr virus infection_Homo sapiens_hsa051690.12738503
99Chemical carcinogenesis_Homo sapiens_hsa052040.12543347
100Phenylalanine metabolism_Homo sapiens_hsa003600.11889720

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