TRAJ39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)8.66557146
2negative T cell selection (GO:0043383)7.45141205
3positive regulation of uterine smooth muscle contraction (GO:0070474)7.44308848
4positive T cell selection (GO:0043368)6.35829355
5T cell migration (GO:0072678)6.23583979
6tachykinin receptor signaling pathway (GO:0007217)6.21224437
7positive regulation of gamma-delta T cell activation (GO:0046645)6.05532664
8negative thymic T cell selection (GO:0045060)5.75661198
9regulation of uterine smooth muscle contraction (GO:0070472)5.73335495
10regulation of gamma-delta T cell differentiation (GO:0045586)5.64680507
11interferon-gamma production (GO:0032609)5.35600681
12positive thymic T cell selection (GO:0045059)5.24535017
13negative regulation of cell killing (GO:0031342)5.16663319
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.16663319
15regulation of B cell receptor signaling pathway (GO:0050855)5.15253461
16regulation of T cell receptor signaling pathway (GO:0050856)5.06139494
17regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.99683622
18T cell receptor signaling pathway (GO:0050852)4.88602243
19positive regulation of T cell differentiation in thymus (GO:0033089)4.81932408
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74398972
21protein K11-linked deubiquitination (GO:0035871)4.73394549
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70357511
23regulation of gamma-delta T cell activation (GO:0046643)4.68799120
24thymic T cell selection (GO:0045061)4.68587451
25negative regulation of T cell apoptotic process (GO:0070233)4.59324676
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42086477
27negative regulation of glycogen biosynthetic process (GO:0045719)4.41687367
28T cell selection (GO:0045058)4.40037624
29Arp2/3 complex-mediated actin nucleation (GO:0034314)4.33066692
30mast cell activation (GO:0045576)4.31899508
31leukocyte aggregation (GO:0070486)4.27449170
32positive regulation of granulocyte differentiation (GO:0030854)4.17289426
33negative regulation of stress fiber assembly (GO:0051497)4.15038844
34cellular response to interleukin-15 (GO:0071350)4.14309819
35regulation of defense response to virus by virus (GO:0050690)4.03560335
36positive regulation of B cell differentiation (GO:0045579)4.03387389
37mitochondrial calcium ion transport (GO:0006851)4.02427738
38antigen processing and presentation of endogenous antigen (GO:0019883)4.00247035
39mast cell activation involved in immune response (GO:0002279)3.98637311
40mast cell degranulation (GO:0043303)3.98637311
41actin nucleation (GO:0045010)3.90109562
42antigen receptor-mediated signaling pathway (GO:0050851)3.83673649
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.83360313
44positive regulation of calcium-mediated signaling (GO:0050850)3.75220741
45positive regulation of T cell cytokine production (GO:0002726)3.73657993
46response to interleukin-15 (GO:0070672)3.61634989
47adenosine metabolic process (GO:0046085)3.52147438
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.52059984
49regulation of energy homeostasis (GO:2000505)3.49978679
50regulation of regulatory T cell differentiation (GO:0045589)3.49758845
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.48008925
52purine-containing compound salvage (GO:0043101)3.47143083
53negative regulation of glycogen metabolic process (GO:0070874)3.44930572
54purine nucleotide salvage (GO:0032261)3.44541716
55regulation of T cell apoptotic process (GO:0070232)3.42628090
56regulation of alpha-beta T cell proliferation (GO:0046640)3.38527404
57positive regulation of smooth muscle contraction (GO:0045987)3.38444898
58negative regulation of execution phase of apoptosis (GO:1900118)3.37170104
59lymphocyte migration (GO:0072676)3.31702107
60antigen processing and presentation via MHC class Ib (GO:0002475)3.30580670
61purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.27429280
62T cell costimulation (GO:0031295)3.27300298
63purine deoxyribonucleotide catabolic process (GO:0009155)3.27139251
64regulation of isotype switching to IgG isotypes (GO:0048302)3.24699471
65lymphocyte costimulation (GO:0031294)3.23280739
66tongue development (GO:0043586)3.20623662
67regulation of B cell differentiation (GO:0045577)3.16199437
68positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.14495185
69regulation of natural killer cell mediated immunity (GO:0002715)3.13778704
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.13778704
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.12961277
72positive regulation of natural killer cell mediated immunity (GO:0002717)3.12314056
73G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.12051165
74regulation of T cell differentiation in thymus (GO:0033081)3.10101790
75deoxyribose phosphate biosynthetic process (GO:0046385)3.09256248
762-deoxyribonucleotide biosynthetic process (GO:0009265)3.09256248
77regulation of thymocyte apoptotic process (GO:0070243)3.06205211
78T cell differentiation (GO:0030217)3.05912507
79chemokine-mediated signaling pathway (GO:0070098)3.05706754
80alpha-beta T cell differentiation (GO:0046632)3.04189892
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03968601
82regulation of T cell mediated cytotoxicity (GO:0001914)3.03116852
83positive regulation of humoral immune response (GO:0002922)3.02758403
84cellular response to zinc ion (GO:0071294)3.02260728
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00184519
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99014616
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98039855
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.97320032
89positive regulation of interleukin-2 production (GO:0032743)2.97163114
90positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94349608
91negative regulation of lymphocyte apoptotic process (GO:0070229)2.93262459
92regulation of cell killing (GO:0031341)2.92296606
93negative regulation of actin filament bundle assembly (GO:0032232)2.91395471
94purine deoxyribonucleotide metabolic process (GO:0009151)2.87312584
95positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.85673034
96negative regulation of T cell receptor signaling pathway (GO:0050860)2.80256186
97positive regulation of T cell mediated immunity (GO:0002711)2.78412939
98positive regulation of cell killing (GO:0031343)2.76770393
99deoxyribose phosphate catabolic process (GO:0046386)2.75195418
100negative regulation of thymocyte apoptotic process (GO:0070244)2.70877740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.33438647
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.37196480
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.11139602
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.10173323
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.98413346
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.67918866
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.35790294
8RUNX_20019798_ChIP-Seq_JUKART_Human3.03844853
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.01840899
10MYB_26560356_Chip-Seq_TH2_Human2.72557179
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42435846
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34470511
13GATA3_27048872_Chip-Seq_THYMUS_Human2.21453478
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.15472905
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13485351
16MYB_26560356_Chip-Seq_TH1_Human2.09575094
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05938505
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.05176107
19UTX_26944678_Chip-Seq_JUKART_Human2.02961874
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94556909
21IGF1R_20145208_ChIP-Seq_DFB_Human1.81360574
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80677862
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80395765
24MAF_26560356_Chip-Seq_TH2_Human1.78150856
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72863898
26MAF_26560356_Chip-Seq_TH1_Human1.61396890
27BCAT_22108803_ChIP-Seq_LS180_Human1.59383388
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54620092
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47962108
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.45413798
31GATA3_26560356_Chip-Seq_TH2_Human1.43934280
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36729918
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34645779
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34409527
35EZH2_22144423_ChIP-Seq_EOC_Human1.32084136
36PHF8_20622853_ChIP-Seq_HELA_Human1.25152855
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23483706
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22071294
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18766909
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17954551
41GATA6_21074721_ChIP-Seq_CACO-2_Human1.16341043
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15910036
43TP53_22573176_ChIP-Seq_HFKS_Human1.11559312
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.09737760
45SPI1_20517297_ChIP-Seq_HL60_Human1.08471674
46NFYA_21822215_ChIP-Seq_K562_Human1.08238801
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.07321886
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07285562
49ETV1_20927104_ChIP-Seq_GIST48_Human1.06586438
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06078516
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05838374
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05101983
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04842919
54VDR_22108803_ChIP-Seq_LS180_Human1.04402467
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03552020
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03260096
57VDR_23849224_ChIP-Seq_CD4+_Human1.02657344
58NANOG_20526341_ChIP-Seq_ESCs_Human1.01303242
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00769274
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98740917
61BCL6_27268052_Chip-Seq_Bcells_Human0.98132597
62FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97820961
63FOXA1_25329375_ChIP-Seq_VCAP_Human0.97820961
64HTT_18923047_ChIP-ChIP_STHdh_Human0.97349297
65P300_27268052_Chip-Seq_Bcells_Human0.95962648
66NCOR_22424771_ChIP-Seq_293T_Human0.95188314
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94728545
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94690974
69CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94012744
70RBPJ_21746931_ChIP-Seq_IB4_Human0.93982317
71HNFA_21074721_ChIP-Seq_CACO-2_Human0.93472468
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90862291
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89427263
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89083119
75SPI1_23547873_ChIP-Seq_NB4_Human0.88849793
76BCOR_27268052_Chip-Seq_Bcells_Human0.87613089
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85798328
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85204255
79AR_20517297_ChIP-Seq_VCAP_Human0.85084690
80NFYB_21822215_ChIP-Seq_K562_Human0.84102123
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.83547841
82STAT1_20625510_ChIP-Seq_HELA_Human0.82941058
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82454055
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81509520
85SCL_19346495_ChIP-Seq_HPC-7_Human0.81021337
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.80722247
87PHF8_20622854_ChIP-Seq_HELA_Human0.79743738
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.74214124
89DROSHA_22980978_ChIP-Seq_HELA_Human0.73904298
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.73609427
91E2F1_20622854_ChIP-Seq_HELA_Human0.73531389
92NANOG_19829295_ChIP-Seq_ESCs_Human0.72037184
93SOX2_19829295_ChIP-Seq_ESCs_Human0.72037184
94ETS1_21867929_ChIP-Seq_TH2_Mouse0.71688046
95OCT4_20526341_ChIP-Seq_ESCs_Human0.70753097
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.70683800
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70432291
98CBP_20019798_ChIP-Seq_JUKART_Human0.69414195
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.69414195
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69186970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.45458388
2MP0003763_abnormal_thymus_physiology4.77762765
3MP0003646_muscle_fatigue4.52566985
4MP0003878_abnormal_ear_physiology3.58637133
5MP0005377_hearing/vestibular/ear_phenot3.58637133
6MP0003806_abnormal_nucleotide_metabolis2.89538520
7MP0009785_altered_susceptibility_to2.75028684
8MP0003436_decreased_susceptibility_to2.32399654
9MP0005025_abnormal_response_to2.29549083
10MP0005000_abnormal_immune_tolerance2.26401965
11MP0004381_abnormal_hair_follicle2.21663520
12MP0001800_abnormal_humoral_immune2.21613613
13MP0005645_abnormal_hypothalamus_physiol2.21510833
14MP0004043_abnormal_pH_regulation2.18893247
15MP0003786_premature_aging2.16138188
16MP0002102_abnormal_ear_morphology2.05870255
17MP0002723_abnormal_immune_serum2.04397465
18MP0005075_abnormal_melanosome_morpholog2.03900310
19MP0002420_abnormal_adaptive_immunity2.03748314
20MP0001542_abnormal_bone_strength2.02917458
21MP0001819_abnormal_immune_cell1.99745381
22MP0003866_abnormal_defecation1.99568098
23MP0003724_increased_susceptibility_to1.92231097
24MP0003252_abnormal_bile_duct1.87865981
25MP0001835_abnormal_antigen_presentation1.87740506
26MP0002405_respiratory_system_inflammati1.86484832
27MP0005360_urolithiasis1.82971175
28MP0002452_abnormal_antigen_presenting1.82961359
29MP0000703_abnormal_thymus_morphology1.81405295
30MP0005503_abnormal_tendon_morphology1.77586374
31MP0002933_joint_inflammation1.64385031
32MP0005275_abnormal_skin_tensile1.63782045
33MP0000716_abnormal_immune_system1.57110032
34MP0002419_abnormal_innate_immunity1.54807284
35MP0001790_abnormal_immune_system1.53861850
36MP0005387_immune_system_phenotype1.53861850
37MP0002398_abnormal_bone_marrow1.52567447
38MP0003045_fibrosis1.51724427
39MP0002148_abnormal_hypersensitivity_rea1.48284427
40MP0001533_abnormal_skeleton_physiology1.47212477
41MP0006082_CNS_inflammation1.44186331
42MP0000689_abnormal_spleen_morphology1.41161920
43MP0009333_abnormal_splenocyte_physiolog1.40218963
44MP0005410_abnormal_fertilization1.38503700
45MP0001845_abnormal_inflammatory_respons1.37906646
46MP0002722_abnormal_immune_system1.37006501
47MP0000685_abnormal_immune_system1.34142300
48MP0002166_altered_tumor_susceptibility1.33303721
49MP0008438_abnormal_cutaneous_collagen1.32758939
50MP0005551_abnormal_eye_electrophysiolog1.25421648
51MP0010386_abnormal_urinary_bladder1.25158970
52MP0010155_abnormal_intestine_physiology1.25028162
53MP0003011_delayed_dark_adaptation1.18649026
54MP0002396_abnormal_hematopoietic_system1.17396340
55MP0002653_abnormal_ependyma_morphology1.17362186
56MP0001919_abnormal_reproductive_system1.17093454
57MP0002429_abnormal_blood_cell1.13540018
58MP0003638_abnormal_response/metabolism_1.11973211
59MP0005389_reproductive_system_phenotype1.10736181
60MP0003075_altered_response_to1.09639298
61MP0002163_abnormal_gland_morphology1.06361300
62MP0005266_abnormal_metabolism1.06147527
63MP0003448_altered_tumor_morphology1.04654027
64MP0001243_abnormal_dermal_layer1.03739239
65MP0002136_abnormal_kidney_physiology1.02144654
66MP0001765_abnormal_ion_homeostasis0.96744395
67MP0004145_abnormal_muscle_electrophysio0.96424344
68MP0000372_irregular_coat_pigmentation0.94548318
69MP0004130_abnormal_muscle_cell0.94398648
70MP0005166_decreased_susceptibility_to0.93333132
71MP0002277_abnormal_respiratory_mucosa0.91940066
72MP0002693_abnormal_pancreas_physiology0.91856104
73MP0001984_abnormal_olfaction0.91038447
74MP0005464_abnormal_platelet_physiology0.90673955
75MP0003195_calcinosis0.90030898
76MP0009643_abnormal_urine_homeostasis0.87479712
77MP0005451_abnormal_body_composition0.85262408
78MP0001963_abnormal_hearing_physiology0.83330633
79MP0008469_abnormal_protein_level0.82130592
80MP0002006_tumorigenesis0.81452680
81MP0001873_stomach_inflammation0.80215792
82MP0002160_abnormal_reproductive_system0.79774035
83MP0004142_abnormal_muscle_tone0.77385688
84MP0009840_abnormal_foam_cell0.74787487
85MP0003950_abnormal_plasma_membrane0.74371279
86MP0000678_abnormal_parathyroid_gland0.74242723
87MP0001879_abnormal_lymphatic_vessel0.72667304
88MP0001501_abnormal_sleep_pattern0.70923789
89MP0005647_abnormal_sex_gland0.69668179
90MP0003690_abnormal_glial_cell0.68588196
91MP0002272_abnormal_nervous_system0.68544550
92MP0002108_abnormal_muscle_morphology0.68400208
93MP0001485_abnormal_pinna_reflex0.68359275
94MP0009764_decreased_sensitivity_to0.66527193
95MP0001119_abnormal_female_reproductive0.66138254
96MP0005390_skeleton_phenotype0.64083101
97MP0000026_abnormal_inner_ear0.62460555
98MP0000015_abnormal_ear_pigmentation0.62381302
99MP0003633_abnormal_nervous_system0.58360427
100MP0002234_abnormal_pharynx_morphology0.55151005

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)6.05639210
2Autoimmune hemolytic anemia (HP:0001890)5.85802962
3Elevated erythrocyte sedimentation rate (HP:0003565)5.64445942
4T lymphocytopenia (HP:0005403)5.56164283
5Abnormality of T cell number (HP:0011839)5.27502701
6Autoimmune thrombocytopenia (HP:0001973)5.01596376
7Aplastic anemia (HP:0001915)4.92027141
8Abnormality of T cells (HP:0002843)4.86224248
9Combined immunodeficiency (HP:0005387)4.76069797
10Thyroiditis (HP:0100646)4.68079520
11Pigmentary retinal degeneration (HP:0001146)4.30527740
12Gastrointestinal infarctions (HP:0005244)4.30316921
13IgG deficiency (HP:0004315)4.30082377
14Chronic diarrhea (HP:0002028)4.17252781
15IgM deficiency (HP:0002850)4.10161021
16Stomatitis (HP:0010280)4.09272229
17Abnormality of B cell number (HP:0010975)4.07234108
18Abnormality of T cell physiology (HP:0011840)4.00717289
19B lymphocytopenia (HP:0010976)3.80800567
20Hyperlipoproteinemia (HP:0010980)3.47814604
21Increased circulating renin level (HP:0000848)3.19670610
22Abnormality of macrophages (HP:0004311)3.19657075
233-Methylglutaconic aciduria (HP:0003535)3.12704078
24Hypoproteinemia (HP:0003075)2.92760402
25Type I transferrin isoform profile (HP:0003642)2.91812367
26Eczematoid dermatitis (HP:0000976)2.85328210
27Panhypogammaglobulinemia (HP:0003139)2.79598802
28Tetany (HP:0001281)2.78454304
29Lymphopenia (HP:0001888)2.76954957
30Hypomagnesemia (HP:0002917)2.74574774
31Abnormality of eosinophils (HP:0001879)2.74425259
32Lymphoma (HP:0002665)2.71834084
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.70138095
34Spondylolisthesis (HP:0003302)2.61066792
35Abnormality of cells of the lymphoid lineage (HP:0012140)2.59087580
36Abnormal drinking behavior (HP:0030082)2.52886706
37Polydipsia (HP:0001959)2.52886706
38Vasculitis (HP:0002633)2.44502919
39Large eyes (HP:0001090)2.40926269
40Recurrent bronchitis (HP:0002837)2.39757979
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39672896
42Abnormal protein N-linked glycosylation (HP:0012347)2.39672896
43Abnormal protein glycosylation (HP:0012346)2.39672896
44Abnormal glycosylation (HP:0012345)2.39672896
45Mesangial abnormality (HP:0001966)2.38457474
46Wrist flexion contracture (HP:0001239)2.38159326
47Obstructive lung disease (HP:0006536)2.36993406
48Chronic obstructive pulmonary disease (HP:0006510)2.36993406
49Abnormality of magnesium homeostasis (HP:0004921)2.35850099
50Micronodular cirrhosis (HP:0001413)2.33273108
51Nonimmune hydrops fetalis (HP:0001790)2.23633708
52Hyperactive renin-angiotensin system (HP:0000841)2.18330057
53Reduced antithrombin III activity (HP:0001976)2.17226378
54Abnormal rod and cone electroretinograms (HP:0008323)2.12444183
55Recurrent sinusitis (HP:0011108)2.08917725
56Eosinophilia (HP:0001880)2.06972189
57Leukocytosis (HP:0001974)2.05867889
58Polyuria (HP:0000103)2.05355473
59Abnormality of the renal collecting system (HP:0004742)2.03889958
60Alkalosis (HP:0001948)2.03572001
61Genetic anticipation (HP:0003743)2.01862085
62Dysphonia (HP:0001618)2.01637643
63Hypokalemic alkalosis (HP:0001949)2.01240882
64Pancytopenia (HP:0001876)2.00958419
65Congenital stationary night blindness (HP:0007642)2.00851173
66Recurrent fungal infections (HP:0002841)2.00301024
67Abnormality of renin-angiotensin system (HP:0000847)1.97437524
68Large for gestational age (HP:0001520)1.95601338
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93859364
70Chest pain (HP:0100749)1.92923811
71Metaphyseal dysplasia (HP:0100255)1.90721627
72Subacute progressive viral hepatitis (HP:0006572)1.90265273
73Abnormality of chloride homeostasis (HP:0011422)1.88169272
74Increased corneal curvature (HP:0100692)1.87178467
75Keratoconus (HP:0000563)1.87178467
76Hepatocellular necrosis (HP:0001404)1.86069285
77Abnormality of the aortic arch (HP:0012303)1.86034256
78Recurrent viral infections (HP:0004429)1.85253464
79Abnormal spermatogenesis (HP:0008669)1.85127922
80Mitochondrial inheritance (HP:0001427)1.83718282
81Stomach cancer (HP:0012126)1.82894628
82Abnormal urine output (HP:0012590)1.81352744
83Metabolic alkalosis (HP:0200114)1.79451445
84Gangrene (HP:0100758)1.76886578
85Hypokalemia (HP:0002900)1.76132444
86Amelogenesis imperfecta (HP:0000705)1.75192758
87Neutropenia (HP:0001875)1.74836797
88Bronchiectasis (HP:0002110)1.74464773
89Sensory axonal neuropathy (HP:0003390)1.73375938
90Myositis (HP:0100614)1.71371271
91Renal salt wasting (HP:0000127)1.68619372
92Abnormality of the prostate (HP:0008775)1.68419016
93Increased IgE level (HP:0003212)1.67666048
94Progressive cerebellar ataxia (HP:0002073)1.67528331
95Optic neuritis (HP:0100653)1.66984286
96Retrobulbar optic neuritis (HP:0100654)1.66984286
97Poor head control (HP:0002421)1.66200527
98Acute necrotizing encephalopathy (HP:0006965)1.65939424
99Recurrent otitis media (HP:0000403)1.63086163
100Abnormality of pyrimidine metabolism (HP:0004353)1.61465789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.19112982
2TXK5.88840579
3SCYL25.23576654
4PASK4.96900790
5MAP3K123.61661905
6TAOK33.58050230
7KDR3.12239352
8ZAP702.96596834
9MAP4K12.91829796
10TESK12.55846652
11ITK2.49780806
12MAP3K112.41017935
13CAMKK12.19378784
14CSK1.89089134
15TEC1.87423100
16LIMK11.73511908
17FES1.71243167
18NLK1.56727180
19ZAK1.47404767
20WNK41.46097488
21SYK1.39449904
22RPS6KA41.39001851
23BTK1.38462493
24JAK31.33921424
25CLK11.23060831
26ADRBK21.20109633
27IKBKE1.17438876
28LCK1.13064660
29RIPK41.05814238
30TAOK21.04559555
31MAPK151.04333599
32TNK20.97623300
33MST40.95623511
34LYN0.86021644
35BLK0.84672896
36RPS6KA50.79939639
37OXSR10.79053977
38GRK60.74558590
39NEK10.71237496
40PRKCQ0.70318514
41CSF1R0.67200997
42TLK10.66888516
43STK390.62830548
44TBK10.60822977
45MAP3K30.60515236
46HCK0.59996781
47MAP3K130.59778670
48PIM10.56486687
49MAP3K50.53627681
50CAMK10.47876058
51FYN0.47116926
52JAK10.46936474
53GRK10.46567663
54IGF1R0.46537485
55IRAK40.46276531
56MYLK0.44305082
57CDK30.42150169
58FRK0.42020049
59MAP2K30.39231574
60SGK20.38587854
61SGK30.37335798
62CAMKK20.36478022
63MAPK130.36234994
64GRK50.35096232
65TYK20.34865862
66SGK2230.32529825
67SGK4940.32529825
68MAP3K70.32183757
69WNK10.32075953
70GRK70.30649412
71PDGFRB0.29985431
72INSR0.29043593
73INSRR0.28746110
74NUAK10.28693807
75FGR0.24803695
76SGK10.24414113
77OBSCN0.23741238
78PRKCA0.20681224
79IKBKB0.20480948
80MAP2K40.19418355
81STK110.19285167
82TIE10.19258534
83ADRBK10.18786270
84AKT30.17434438
85RIPK10.16245867
86ROCK10.15847992
87PRKCB0.15368045
88PRKACA0.12921994
89PTK2B0.12884927
90MAP2K60.11448260
91DYRK1B0.11020748
92MAPKAPK20.10765108
93PIK3CG0.10422680
94DYRK30.10137190
95CDK190.09919017
96LRRK20.09064321
97PIM20.07964324
98PRKCI0.07952773
99PRKCZ0.07375840
100CAMK2G0.07242991

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.47692553
2T cell receptor signaling pathway_Homo sapiens_hsa046603.63853710
3Antigen processing and presentation_Homo sapiens_hsa046123.04580717
4Proteasome_Homo sapiens_hsa030502.98736313
5Hematopoietic cell lineage_Homo sapiens_hsa046402.70570666
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.66874189
7Malaria_Homo sapiens_hsa051442.41433000
8Graft-versus-host disease_Homo sapiens_hsa053322.08267365
9Allograft rejection_Homo sapiens_hsa053301.95844439
10Autoimmune thyroid disease_Homo sapiens_hsa053201.93686304
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.89605851
12Phototransduction_Homo sapiens_hsa047441.89423880
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66387250
14Ribosome_Homo sapiens_hsa030101.64546671
15Type I diabetes mellitus_Homo sapiens_hsa049401.62482370
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.61812199
17Measles_Homo sapiens_hsa051621.55652381
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53239590
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51295465
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47521245
21Retinol metabolism_Homo sapiens_hsa008301.37619177
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36259057
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35705790
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.32441558
25Oxidative phosphorylation_Homo sapiens_hsa001901.27816802
26Viral myocarditis_Homo sapiens_hsa054161.20814235
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20041946
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06517542
29Fatty acid biosynthesis_Homo sapiens_hsa000611.05893959
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05123169
31Olfactory transduction_Homo sapiens_hsa047401.04113489
32Osteoclast differentiation_Homo sapiens_hsa043801.02101827
33One carbon pool by folate_Homo sapiens_hsa006700.98760741
34TNF signaling pathway_Homo sapiens_hsa046680.98138346
35Parkinsons disease_Homo sapiens_hsa050120.95656099
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95132960
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94781628
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94512919
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94334375
40Starch and sucrose metabolism_Homo sapiens_hsa005000.91990370
41Mineral absorption_Homo sapiens_hsa049780.88005620
42Other glycan degradation_Homo sapiens_hsa005110.83540973
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.81252507
44Legionellosis_Homo sapiens_hsa051340.80516499
45Alzheimers disease_Homo sapiens_hsa050100.78489480
46Staphylococcus aureus infection_Homo sapiens_hsa051500.78262499
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.76511063
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76178462
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73823483
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73465566
51Chemokine signaling pathway_Homo sapiens_hsa040620.70438887
52ABC transporters_Homo sapiens_hsa020100.70333972
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69076590
54Morphine addiction_Homo sapiens_hsa050320.66487173
55Nicotine addiction_Homo sapiens_hsa050330.64376061
56Shigellosis_Homo sapiens_hsa051310.62691286
57Cardiac muscle contraction_Homo sapiens_hsa042600.62440509
58Renin secretion_Homo sapiens_hsa049240.62017597
59Linoleic acid metabolism_Homo sapiens_hsa005910.60391341
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60236877
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58958844
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58289996
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57924180
64Herpes simplex infection_Homo sapiens_hsa051680.56498656
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.54128917
66Pertussis_Homo sapiens_hsa051330.53465294
67MAPK signaling pathway_Homo sapiens_hsa040100.52275540
68Nitrogen metabolism_Homo sapiens_hsa009100.51095256
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.50143975
70Chemical carcinogenesis_Homo sapiens_hsa052040.48627531
71Calcium signaling pathway_Homo sapiens_hsa040200.48427780
72Ras signaling pathway_Homo sapiens_hsa040140.47433247
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47388163
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.44264451
75Rheumatoid arthritis_Homo sapiens_hsa053230.44211840
76Bile secretion_Homo sapiens_hsa049760.44009321
77Fanconi anemia pathway_Homo sapiens_hsa034600.40353836
78Tuberculosis_Homo sapiens_hsa051520.40033198
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37670146
80Peroxisome_Homo sapiens_hsa041460.37475870
81HTLV-I infection_Homo sapiens_hsa051660.35932849
82Complement and coagulation cascades_Homo sapiens_hsa046100.34436231
83Epstein-Barr virus infection_Homo sapiens_hsa051690.33127212
84Endocytosis_Homo sapiens_hsa041440.31030562
85B cell receptor signaling pathway_Homo sapiens_hsa046620.30881645
86Systemic lupus erythematosus_Homo sapiens_hsa053220.30041158
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29166856
88Apoptosis_Homo sapiens_hsa042100.28517753
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27963954
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27457177
91Huntingtons disease_Homo sapiens_hsa050160.26532698
92Purine metabolism_Homo sapiens_hsa002300.26249596
93Ovarian steroidogenesis_Homo sapiens_hsa049130.26115109
94Salivary secretion_Homo sapiens_hsa049700.24723888
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24305716
96Taste transduction_Homo sapiens_hsa047420.24072396
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23637566
98RNA polymerase_Homo sapiens_hsa030200.21415827
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20404476
100Asthma_Homo sapiens_hsa053100.19841347

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