TRAJ40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)7.06015863
2negative T cell selection (GO:0043383)6.53855757
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.20912484
4positive thymic T cell selection (GO:0045059)6.14874250
5positive regulation of uterine smooth muscle contraction (GO:0070474)5.88873526
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.88172107
7positive regulation of natural killer cell mediated immunity (GO:0002717)5.82027256
8positive regulation of gamma-delta T cell activation (GO:0046645)5.78519337
9T cell migration (GO:0072678)5.58991148
10respiratory burst (GO:0045730)5.00330119
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.91673368
12regulation of natural killer cell mediated immunity (GO:0002715)4.91673368
13positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.88581202
14cellular response to interleukin-15 (GO:0071350)4.86923482
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.81702067
16tachykinin receptor signaling pathway (GO:0007217)4.77464773
17negative thymic T cell selection (GO:0045060)4.68381447
18negative regulation of stress fiber assembly (GO:0051497)4.64251131
19thymic T cell selection (GO:0045061)4.63587557
20positive regulation of cell killing (GO:0031343)4.55434572
21regulation of uterine smooth muscle contraction (GO:0070472)4.55254699
22mast cell activation (GO:0045576)4.48010664
23T cell selection (GO:0045058)4.46940283
24regulation of leukocyte mediated cytotoxicity (GO:0001910)4.35801115
25pyrimidine ribonucleoside catabolic process (GO:0046133)4.26524899
26T cell receptor signaling pathway (GO:0050852)4.24828367
27positive regulation of calcium-mediated signaling (GO:0050850)4.20579325
28positive regulation of hair follicle development (GO:0051798)4.19935986
29positive regulation of hair cycle (GO:0042635)4.19935986
30interferon-gamma production (GO:0032609)4.13970600
31Arp2/3 complex-mediated actin nucleation (GO:0034314)4.07907663
32regulation of cell killing (GO:0031341)4.06095806
33positive regulation of tolerance induction (GO:0002645)4.05948412
34regulation of gamma-delta T cell differentiation (GO:0045586)4.05245717
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03236864
36positive regulation of protein homodimerization activity (GO:0090073)4.01962652
37positive regulation of T cell cytokine production (GO:0002726)3.99320015
38actin nucleation (GO:0045010)3.96786007
39T cell mediated immunity (GO:0002456)3.95620709
40regulation of gamma-delta T cell activation (GO:0046643)3.93879562
41mitochondrial calcium ion transport (GO:0006851)3.92558494
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.85813950
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84377592
44negative regulation of cell killing (GO:0031342)3.84377592
45regulation of regulatory T cell differentiation (GO:0045589)3.82719736
46cytolysis (GO:0019835)3.82252340
47negative regulation of actin filament bundle assembly (GO:0032232)3.80202329
48cytidine deamination (GO:0009972)3.75627104
49cytidine metabolic process (GO:0046087)3.75627104
50cytidine catabolic process (GO:0006216)3.75627104
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74735211
52positive regulation of humoral immune response (GO:0002922)3.65894664
53negative regulation of glial cell proliferation (GO:0060253)3.65642100
54regulation of T cell tolerance induction (GO:0002664)3.64316765
55leukocyte aggregation (GO:0070486)3.61150210
56lymphocyte migration (GO:0072676)3.60714153
57response to interleukin-15 (GO:0070672)3.56209086
58regulation of T cell mediated cytotoxicity (GO:0001914)3.54571565
59regulation of ruffle assembly (GO:1900027)3.54556446
60negative regulation of myeloid cell apoptotic process (GO:0033033)3.53464945
61mast cell degranulation (GO:0043303)3.43907822
62mast cell activation involved in immune response (GO:0002279)3.43907822
63positive regulation of T cell mediated immunity (GO:0002711)3.43012863
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42918445
65regulation of alpha-beta T cell proliferation (GO:0046640)3.40870942
66positive regulation of lymphocyte mediated immunity (GO:0002708)3.40644423
67sulfation (GO:0051923)3.40182254
68antigen receptor-mediated signaling pathway (GO:0050851)3.39877059
69antigen processing and presentation via MHC class Ib (GO:0002475)3.29487547
70T cell costimulation (GO:0031295)3.28551139
71regulation of activation of Janus kinase activity (GO:0010533)3.26899327
72lymphocyte costimulation (GO:0031294)3.25133017
73natural killer cell activation (GO:0030101)3.24742618
74erythrocyte maturation (GO:0043249)3.22095420
75regulation of tolerance induction (GO:0002643)3.21653928
76DNA deamination (GO:0045006)3.21181681
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.20928958
78T cell differentiation (GO:0030217)3.20310973
79regulation of T cell receptor signaling pathway (GO:0050856)3.19953651
80purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.17617443
81regulation of calcium-mediated signaling (GO:0050848)3.14798211
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13475905
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12931052
84ribosomal small subunit assembly (GO:0000028)3.11446918
85regulation of T cell mediated immunity (GO:0002709)3.03733750
86T cell activation (GO:0042110)3.00537120
87positive regulation of leukocyte mediated immunity (GO:0002705)2.99069136
88regulation of B cell receptor signaling pathway (GO:0050855)2.98654169
89negative regulation of T cell mediated immunity (GO:0002710)2.95410828
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95243805
91sequestering of actin monomers (GO:0042989)2.90001494
92erythrocyte development (GO:0048821)2.88537851
93regulation of defense response to virus by virus (GO:0050690)2.87929418
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.86256238
95tolerance induction (GO:0002507)2.86016766
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84897433
97positive regulation of interleukin-4 production (GO:0032753)2.84615056
98ATP synthesis coupled proton transport (GO:0015986)2.83518463
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83518463
100positive regulation of fatty acid oxidation (GO:0046321)2.82581130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.25275678
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.47037938
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37548203
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.85882962
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29618048
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.11647048
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.77789850
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65676719
9RUNX_20019798_ChIP-Seq_JUKART_Human3.23595374
10MYB_26560356_Chip-Seq_TH2_Human3.02198413
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88911171
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.88848246
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75587182
14VDR_22108803_ChIP-Seq_LS180_Human2.47544038
15MYB_26560356_Chip-Seq_TH1_Human2.32830836
16GATA3_27048872_Chip-Seq_THYMUS_Human2.20720601
17UTX_26944678_Chip-Seq_JUKART_Human2.20537582
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18922833
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17458940
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13092059
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12387594
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.06669277
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06029341
24GATA3_26560356_Chip-Seq_TH2_Human1.99757316
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89547448
26EZH2_22144423_ChIP-Seq_EOC_Human1.86924352
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80160858
28HTT_18923047_ChIP-ChIP_STHdh_Human1.75238853
29ERG_20517297_ChIP-Seq_VCAP_Human1.54057730
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53573717
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50343432
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48494784
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.44224200
34VDR_23849224_ChIP-Seq_CD4+_Human1.36692767
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27993947
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26041140
37SPI1_23547873_ChIP-Seq_NB4_Human1.25497900
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25484754
39MAF_26560356_Chip-Seq_TH1_Human1.25248233
40MAF_26560356_Chip-Seq_TH2_Human1.23632983
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21696312
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18247822
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.16664312
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13288271
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11087144
46GBX2_23144817_ChIP-Seq_PC3_Human1.11071232
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06164912
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05964740
49NANOG_20526341_ChIP-Seq_ESCs_Human1.05930987
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05834367
51FOXP3_21729870_ChIP-Seq_TREG_Human1.05751348
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.03610301
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.00497623
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99432611
55BCAT_22108803_ChIP-Seq_LS180_Human0.98532917
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98187289
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94555708
58TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94367964
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94352835
60CRX_20693478_ChIP-Seq_RETINA_Mouse0.94292350
61EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92780166
62ELF1_20517297_ChIP-Seq_JURKAT_Human0.91815668
63CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90644944
64GATA3_21878914_ChIP-Seq_MCF-7_Human0.89409311
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89135894
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87335238
67EGR1_19032775_ChIP-ChIP_M12_Human0.86924942
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85671276
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85410368
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83768831
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83606912
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82196981
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81552052
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.81411269
75NCOR_22424771_ChIP-Seq_293T_Human0.81368741
76P300_27268052_Chip-Seq_Bcells_Human0.81038559
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80144758
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79437785
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78393847
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78363507
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.77564633
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76728789
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76430551
84SPI1_20517297_ChIP-Seq_HL60_Human0.76264831
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75177736
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74880149
87STAT1_20625510_ChIP-Seq_HELA_Human0.73643292
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73200360
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.73200360
90TP53_22573176_ChIP-Seq_HFKS_Human0.72346787
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71926095
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.71612166
93BCL6_27268052_Chip-Seq_Bcells_Human0.71392275
94NANOG_19829295_ChIP-Seq_ESCs_Human0.71120650
95SOX2_19829295_ChIP-Seq_ESCs_Human0.71120650
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70778935
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.69616924
98CTCF_20526341_ChIP-Seq_ESCs_Human0.69592154
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69533031
100PHF8_20622853_ChIP-Seq_HELA_Human0.68381520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.60358137
2MP0005451_abnormal_body_composition5.31680395
3MP0003763_abnormal_thymus_physiology3.39288764
4MP0009785_altered_susceptibility_to3.05269454
5MP0003123_paternal_imprinting3.02940731
6MP0003787_abnormal_imprinting3.02816727
7MP0001800_abnormal_humoral_immune2.59162709
8MP0002822_catalepsy2.58388892
9MP0003724_increased_susceptibility_to2.57475455
10MP0005025_abnormal_response_to2.57419125
11MP0009333_abnormal_splenocyte_physiolog2.56515841
12MP0005000_abnormal_immune_tolerance2.54266855
13MP0005646_abnormal_pituitary_gland2.50249845
14MP0001835_abnormal_antigen_presentation2.47253425
15MP0002420_abnormal_adaptive_immunity2.44197020
16MP0001819_abnormal_immune_cell2.42231511
17MP0000685_abnormal_immune_system2.39006257
18MP0002723_abnormal_immune_serum2.27638761
19MP0004947_skin_inflammation2.17217849
20MP0000372_irregular_coat_pigmentation2.10601090
21MP0002452_abnormal_antigen_presenting2.01636034
22MP0005387_immune_system_phenotype2.01596337
23MP0001790_abnormal_immune_system2.01596337
24MP0008995_early_reproductive_senescence1.98726452
25MP0000716_abnormal_immune_system1.94573752
26MP0002419_abnormal_innate_immunity1.91942926
27MP0005075_abnormal_melanosome_morpholog1.90863073
28MP0010155_abnormal_intestine_physiology1.85402728
29MP0002398_abnormal_bone_marrow1.77575111
30MP0003436_decreased_susceptibility_to1.72474998
31MP0002166_altered_tumor_susceptibility1.69376553
32MP0003880_abnormal_central_pattern1.66088678
33MP0008961_abnormal_basal_metabolism1.63597005
34MP0000703_abnormal_thymus_morphology1.61265305
35MP0008260_abnormal_autophagy1.60966211
36MP0003646_muscle_fatigue1.59097964
37MP0002148_abnormal_hypersensitivity_rea1.50802825
38MP0009764_decreased_sensitivity_to1.47713482
39MP0001845_abnormal_inflammatory_respons1.47192798
40MP0002405_respiratory_system_inflammati1.43172568
41MP0003866_abnormal_defecation1.41959774
42MP0002722_abnormal_immune_system1.36916555
43MP0002429_abnormal_blood_cell1.36675296
44MP0000689_abnormal_spleen_morphology1.32791115
45MP0002102_abnormal_ear_morphology1.31231246
46MP0005410_abnormal_fertilization1.28907610
47MP0005503_abnormal_tendon_morphology1.28389155
48MP0005645_abnormal_hypothalamus_physiol1.27827557
49MP0004510_myositis1.26044493
50MP0001873_stomach_inflammation1.25450406
51MP0004381_abnormal_hair_follicle1.22217824
52MP0002006_tumorigenesis1.20104914
53MP0002933_joint_inflammation1.16929618
54MP0001984_abnormal_olfaction1.16121990
55MP0008469_abnormal_protein_level1.15614567
56MP0001533_abnormal_skeleton_physiology1.14344245
57MP0008789_abnormal_olfactory_epithelium1.12752014
58MP0001919_abnormal_reproductive_system1.11045564
59MP0002132_abnormal_respiratory_system1.09463772
60MP0001765_abnormal_ion_homeostasis1.06247377
61MP0005171_absent_coat_pigmentation1.04258064
62MP0009763_increased_sensitivity_to1.03950824
63MP0000631_abnormal_neuroendocrine_gland0.98675500
64MP0000490_abnormal_crypts_of0.96495061
65MP0006072_abnormal_retinal_apoptosis0.95159566
66MP0008872_abnormal_physiological_respon0.94359001
67MP0003045_fibrosis0.92812305
68MP0003806_abnormal_nucleotide_metabolis0.92170456
69MP0009840_abnormal_foam_cell0.89239134
70MP0000639_abnormal_adrenal_gland0.88787168
71MP0008875_abnormal_xenobiotic_pharmacok0.85257712
72MP0005636_abnormal_mineral_homeostasis0.84026957
73MP0003448_altered_tumor_morphology0.81265500
74MP0002736_abnormal_nociception_after0.80651347
75MP0009765_abnormal_xenobiotic_induced0.79671341
76MP0003075_altered_response_to0.78286044
77MP0005464_abnormal_platelet_physiology0.77866887
78MP0005389_reproductive_system_phenotype0.76935140
79MP0001905_abnormal_dopamine_level0.76102118
80MP0000858_altered_metastatic_potential0.72559713
81MP0005499_abnormal_olfactory_system0.72507004
82MP0005394_taste/olfaction_phenotype0.72507004
83MP0004043_abnormal_pH_regulation0.71265759
84MP0002234_abnormal_pharynx_morphology0.71139836
85MP0000604_amyloidosis0.70183652
86MP0003690_abnormal_glial_cell0.67179120
87MP0002019_abnormal_tumor_incidence0.66955266
88MP0002837_dystrophic_cardiac_calcinosis0.66884656
89MP0002735_abnormal_chemical_nociception0.66620815
90MP0003950_abnormal_plasma_membrane0.66081336
91MP0002693_abnormal_pancreas_physiology0.64764839
92MP0002638_abnormal_pupillary_reflex0.63001896
93MP0006276_abnormal_autonomic_nervous0.59290311
94MP0005390_skeleton_phenotype0.54683314
95MP0010329_abnormal_lipoprotein_level0.51695865
96MP0002998_abnormal_bone_remodeling0.51439953
97MP0005166_decreased_susceptibility_to0.50343893
98MP0003279_aneurysm0.49588847
99MP0009697_abnormal_copulation0.48901356
100MP0001968_abnormal_touch/_nociception0.48457827

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)6.81211260
2T lymphocytopenia (HP:0005403)6.19115018
3Increased IgM level (HP:0003496)5.67216988
4Abnormality of T cell number (HP:0011839)5.21471928
5Severe combined immunodeficiency (HP:0004430)5.07380782
6Elevated erythrocyte sedimentation rate (HP:0003565)4.36609031
7Combined immunodeficiency (HP:0005387)4.02124038
8Abnormality of T cells (HP:0002843)3.90481865
9Chronic diarrhea (HP:0002028)3.79465404
10Thyroiditis (HP:0100646)3.76408623
11Diastasis recti (HP:0001540)3.53900208
12Acute hepatic failure (HP:0006554)3.45262393
13Abnormality of eosinophils (HP:0001879)3.44623452
14Autoimmune hemolytic anemia (HP:0001890)3.33011425
15Encephalitis (HP:0002383)3.31481333
16Increased intramyocellular lipid droplets (HP:0012240)3.21077732
17IgM deficiency (HP:0002850)3.16870949
18Increased hepatocellular lipid droplets (HP:0006565)3.13880482
19Lipid accumulation in hepatocytes (HP:0006561)3.01888372
20Recurrent bronchitis (HP:0002837)3.00897910
21Thick nail (HP:0001805)2.93745004
22Congenital stationary night blindness (HP:0007642)2.90654423
23Hypoproteinemia (HP:0003075)2.83621659
24Increased muscle lipid content (HP:0009058)2.81620862
25Stenosis of the external auditory canal (HP:0000402)2.73609750
26Hypergammaglobulinemia (HP:0010702)2.72866650
27Pancytopenia (HP:0001876)2.72693699
28Abnormality of macrophages (HP:0004311)2.72246614
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71216345
30Hypoplasia of the uterus (HP:0000013)2.71107188
31Eosinophilia (HP:0001880)2.67765430
32Pustule (HP:0200039)2.62933544
33Hyperlipoproteinemia (HP:0010980)2.62204681
343-Methylglutaconic aciduria (HP:0003535)2.61064230
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59839834
36Chronic otitis media (HP:0000389)2.58479375
37Erythema (HP:0010783)2.53749824
38Exertional dyspnea (HP:0002875)2.46347355
39Leukocytosis (HP:0001974)2.41534625
40Cellular immunodeficiency (HP:0005374)2.41126639
41Granulocytopenia (HP:0001913)2.41117442
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40903195
43Optic neuritis (HP:0100653)2.39087905
44Retrobulbar optic neuritis (HP:0100654)2.39087905
45Bronchiectasis (HP:0002110)2.38444861
46Brushfield spots (HP:0001088)2.37871925
47B lymphocytopenia (HP:0010976)2.36579969
48Renal Fanconi syndrome (HP:0001994)2.35992195
49Constricted visual fields (HP:0001133)2.33049167
50Widely patent fontanelles and sutures (HP:0004492)2.32906249
51Amyotrophic lateral sclerosis (HP:0007354)2.31095324
52Eczematoid dermatitis (HP:0000976)2.29756641
53Myositis (HP:0100614)2.27369481
54Hyperglycinuria (HP:0003108)2.24764272
55Aplastic anemia (HP:0001915)2.24551284
56Abnormality of pyrimidine metabolism (HP:0004353)2.23736123
57Abnormal rod and cone electroretinograms (HP:0008323)2.23353278
58Lymphopenia (HP:0001888)2.21244476
59Septate vagina (HP:0001153)2.17572468
60Recurrent otitis media (HP:0000403)2.14690104
61Abnormality of B cell number (HP:0010975)2.13406203
62Renal cortical cysts (HP:0000803)2.09803938
63Hypoplasia of the thymus (HP:0000778)2.06158477
64Abnormality of the renal cortex (HP:0011035)2.06149556
65Orchitis (HP:0100796)2.01159304
66Bronchitis (HP:0012387)1.99997115
67Meningitis (HP:0001287)1.98922397
68Lymphoma (HP:0002665)1.97535562
69Aplasia/hypoplasia of the uterus (HP:0008684)1.97324450
70Attenuation of retinal blood vessels (HP:0007843)1.96850839
71Recurrent fungal infections (HP:0002841)1.92870771
72Abnormality of T cell physiology (HP:0011840)1.89558329
73Radial bowing (HP:0002986)1.89213684
74Redundant skin (HP:0001582)1.88216999
75Mediastinal lymphadenopathy (HP:0100721)1.87208037
76Abnormality of cells of the lymphoid lineage (HP:0012140)1.85312093
77IgA deficiency (HP:0002720)1.85062823
78Abnormality of fatty-acid metabolism (HP:0004359)1.84232505
79Agammaglobulinemia (HP:0004432)1.83703543
80Alkalosis (HP:0001948)1.82843613
81Female pseudohermaphroditism (HP:0010458)1.80407129
82Recurrent cutaneous fungal infections (HP:0011370)1.80401151
83Chronic mucocutaneous candidiasis (HP:0002728)1.80401151
84Cortical visual impairment (HP:0100704)1.79597471
85Spontaneous hematomas (HP:0007420)1.78958907
86Reticulocytopenia (HP:0001896)1.78819088
87Dyschromatopsia (HP:0007641)1.78784783
88Abnormality of serine family amino acid metabolism (HP:0010894)1.78100505
89Abnormality of glycine metabolism (HP:0010895)1.78100505
90Hyperphosphaturia (HP:0003109)1.77230046
91Conical tooth (HP:0000698)1.75097328
92Hypothermia (HP:0002045)1.74369706
93Vacuolated lymphocytes (HP:0001922)1.73495127
94Stomatitis (HP:0010280)1.72567344
95Rectal fistula (HP:0100590)1.72404900
96Rectovaginal fistula (HP:0000143)1.72404900
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71966157
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69092054
99Dicarboxylic aciduria (HP:0003215)1.69092054
100Abnormal number of erythroid precursors (HP:0012131)1.68574014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.61761657
2ZAK5.49955673
3KDR4.88466069
4TESK24.63097208
5SCYL24.36338667
6TXK3.14897776
7TNK23.13187472
8MAP4K12.48261594
9TESK12.47895901
10VRK12.35914173
11PASK2.30591296
12MAP3K102.01584124
13GRK61.98011549
14VRK21.92815550
15PIK3CG1.90163846
16ZAP701.76432898
17LIMK11.69111778
18ITK1.60310935
19TNIK1.58145597
20TAOK31.42068598
21TEC1.36630727
22FES1.36076854
23SYK1.32867427
24CAMKK11.26281486
25NEK61.26008052
26ADRBK21.25649059
27LRRK21.24366187
28CSK1.19246510
29GRK71.13664119
30BTK1.11619428
31NEK90.98564922
32PIM10.94575336
33CAMKK20.91561152
34MAP3K120.87306149
35MYLK0.85660983
36KIT0.84256502
37LYN0.80230009
38LCK0.79476738
39ROCK10.79291455
40BLK0.78968314
41IKBKE0.77268417
42TAOK20.73442532
43CSF1R0.68760726
44MAPKAPK30.68400670
45HCK0.67255041
46TRPM70.60973959
47PKN10.58640773
48PRKCQ0.57862364
49RPS6KA50.57172267
50MAPK110.53400029
51MAP3K110.51077789
52IKBKB0.50774695
53GRK10.50470394
54FRK0.48289981
55JAK30.47865967
56INSRR0.47522049
57OBSCN0.47259788
58MST40.47194846
59FYN0.46164053
60PINK10.44266653
61ERBB20.44049482
62INSR0.42239007
63ADRBK10.42073509
64CDK80.40796756
65JAK10.37712908
66IGF1R0.35422965
67TYRO30.33991787
68CDK60.33777484
69WNK40.33000813
70RPS6KA40.31320824
71PRKCA0.30456036
72PRKD10.28478916
73EIF2AK10.28069013
74ACVR1B0.28027067
75ILK0.27729338
76MUSK0.27283494
77PDGFRB0.26401945
78JAK20.26360001
79CDK40.25874253
80TBK10.24379060
81FGFR20.23612504
82MELK0.23431445
83NME10.23306330
84NTRK20.21900184
85EGFR0.20339620
86MAP4K20.20033174
87MAP3K130.17933837
88PAK60.17457370
89PRKACA0.16075960
90PAK10.15282862
91PTK2B0.15168879
92ABL10.14973121
93CLK10.14662339
94MAP3K70.14407341
95PRKCD0.14196770
96MAPK150.13380680
97CSNK1G30.12545693
98SRC0.10631993
99PRKCB0.10372154
100RIPK40.09192110

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.20079908
2Antigen processing and presentation_Homo sapiens_hsa046123.51054890
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.31789451
4T cell receptor signaling pathway_Homo sapiens_hsa046603.03816992
5Hematopoietic cell lineage_Homo sapiens_hsa046402.95055134
6Ribosome_Homo sapiens_hsa030102.84424206
7Proteasome_Homo sapiens_hsa030502.54860109
8Malaria_Homo sapiens_hsa051442.51261899
9Oxidative phosphorylation_Homo sapiens_hsa001902.35145248
10Graft-versus-host disease_Homo sapiens_hsa053322.09638109
11Parkinsons disease_Homo sapiens_hsa050122.07956244
12Measles_Homo sapiens_hsa051621.88806272
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82759087
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75443835
15Shigellosis_Homo sapiens_hsa051311.68243845
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61335291
17Allograft rejection_Homo sapiens_hsa053301.49159998
18Nitrogen metabolism_Homo sapiens_hsa009101.48791753
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47157270
20Autoimmune thyroid disease_Homo sapiens_hsa053201.46626051
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.44387169
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42504911
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.41658345
24Alzheimers disease_Homo sapiens_hsa050101.37130696
25Peroxisome_Homo sapiens_hsa041461.36163493
26Phototransduction_Homo sapiens_hsa047441.34035340
27Type I diabetes mellitus_Homo sapiens_hsa049401.29661191
28Homologous recombination_Homo sapiens_hsa034401.25107978
29Cardiac muscle contraction_Homo sapiens_hsa042601.21913793
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21812142
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20146642
32ABC transporters_Homo sapiens_hsa020101.16709591
33Linoleic acid metabolism_Homo sapiens_hsa005911.15291929
34Systemic lupus erythematosus_Homo sapiens_hsa053221.12069370
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08493860
36Caffeine metabolism_Homo sapiens_hsa002321.02517872
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.97474398
38Osteoclast differentiation_Homo sapiens_hsa043800.96312933
39Viral myocarditis_Homo sapiens_hsa054160.86792387
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.86081156
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82903518
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81331477
43Retinol metabolism_Homo sapiens_hsa008300.80275096
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79560049
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.79366441
46Rheumatoid arthritis_Homo sapiens_hsa053230.77349062
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75044855
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72630879
49Staphylococcus aureus infection_Homo sapiens_hsa051500.71955148
50Huntingtons disease_Homo sapiens_hsa050160.70057826
51Chemokine signaling pathway_Homo sapiens_hsa040620.69490503
52TNF signaling pathway_Homo sapiens_hsa046680.68155872
53Legionellosis_Homo sapiens_hsa051340.67594099
54RNA polymerase_Homo sapiens_hsa030200.66525025
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63222841
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60908847
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60872720
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60676483
59Olfactory transduction_Homo sapiens_hsa047400.58118436
60Mismatch repair_Homo sapiens_hsa034300.56305426
61Type II diabetes mellitus_Homo sapiens_hsa049300.54367091
62Chemical carcinogenesis_Homo sapiens_hsa052040.53935018
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53160121
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51838606
65Collecting duct acid secretion_Homo sapiens_hsa049660.51644709
66Salmonella infection_Homo sapiens_hsa051320.49466141
67Asthma_Homo sapiens_hsa053100.49136724
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.47965363
69Tuberculosis_Homo sapiens_hsa051520.47506938
70Platelet activation_Homo sapiens_hsa046110.47217810
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46157358
72Taste transduction_Homo sapiens_hsa047420.45465377
73B cell receptor signaling pathway_Homo sapiens_hsa046620.44884716
74Apoptosis_Homo sapiens_hsa042100.44778084
75Ras signaling pathway_Homo sapiens_hsa040140.44377143
76Toxoplasmosis_Homo sapiens_hsa051450.44365622
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41989690
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41906237
79Leishmaniasis_Homo sapiens_hsa051400.41631677
80Renin secretion_Homo sapiens_hsa049240.40283507
81Ovarian steroidogenesis_Homo sapiens_hsa049130.37568688
82Epstein-Barr virus infection_Homo sapiens_hsa051690.37460787
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36604694
84Protein export_Homo sapiens_hsa030600.36340952
85Herpes simplex infection_Homo sapiens_hsa051680.35966589
86Arachidonic acid metabolism_Homo sapiens_hsa005900.33891028
87Pertussis_Homo sapiens_hsa051330.33885769
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33475496
89Calcium signaling pathway_Homo sapiens_hsa040200.32105995
90Butanoate metabolism_Homo sapiens_hsa006500.30475345
91Fanconi anemia pathway_Homo sapiens_hsa034600.30467188
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.30261920
93Viral carcinogenesis_Homo sapiens_hsa052030.30183647
94Hepatitis C_Homo sapiens_hsa051600.29744154
95Endocytosis_Homo sapiens_hsa041440.27249337
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25612231
97HTLV-I infection_Homo sapiens_hsa051660.24202365
98Nicotine addiction_Homo sapiens_hsa050330.23183538
99Serotonergic synapse_Homo sapiens_hsa047260.22496521
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21790273

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