TRAJ42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)8.58863331
2eosinophil chemotaxis (GO:0048245)7.13263792
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.96851648
4negative regulation by host of viral transcription (GO:0043922)6.91956557
5cellular response to interleukin-15 (GO:0071350)6.70478947
6regulation of mononuclear cell migration (GO:0071675)6.49473929
7positive regulation of T cell chemotaxis (GO:0010820)6.44383426
8regulation of T cell chemotaxis (GO:0010819)6.44383426
9eosinophil migration (GO:0072677)6.42274350
10DNA deamination (GO:0045006)6.33801904
11regulation of macrophage chemotaxis (GO:0010758)6.19886572
12positive regulation of monocyte chemotaxis (GO:0090026)6.00813732
13macrophage chemotaxis (GO:0048246)5.96882939
14regulation of chronic inflammatory response (GO:0002676)5.91168738
15T cell migration (GO:0072678)5.72186061
16regulation of lymphocyte chemotaxis (GO:1901623)5.38038775
17positive regulation of alpha-beta T cell proliferation (GO:0046641)5.31540872
18response to interleukin-15 (GO:0070672)5.24016642
19regulation of chemokine-mediated signaling pathway (GO:0070099)5.19647486
20negative regulation of viral genome replication (GO:0045071)4.86741545
21negative T cell selection (GO:0043383)4.85971657
22regulation of alpha-beta T cell proliferation (GO:0046640)4.75754265
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.71819357
24dendritic cell chemotaxis (GO:0002407)4.66080390
25positive regulation of defense response to virus by host (GO:0002230)4.62483602
26pyrimidine nucleoside catabolic process (GO:0046135)4.59441152
27positive regulation of T cell apoptotic process (GO:0070234)4.54773042
28modulation by host of viral transcription (GO:0043921)4.51503330
29modulation by host of symbiont transcription (GO:0052472)4.51503330
30positive T cell selection (GO:0043368)4.43657300
31lymphocyte chemotaxis (GO:0048247)4.39705941
32monocyte chemotaxis (GO:0002548)4.35649568
33negative regulation of T cell apoptotic process (GO:0070233)4.34786647
34modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.31013737
35positive regulation of calcium-mediated signaling (GO:0050850)4.20362438
36regulation of T cell tolerance induction (GO:0002664)4.15649261
37regulation of monocyte chemotaxis (GO:0090025)4.07401982
38positive thymic T cell selection (GO:0045059)4.04690582
39negative regulation of viral transcription (GO:0032897)4.03721443
40positive regulation of lymphocyte migration (GO:2000403)3.99915045
41positive regulation of gamma-delta T cell activation (GO:0046645)3.99245731
42granulocyte activation (GO:0036230)3.98617132
43negative thymic T cell selection (GO:0045060)3.96465662
44positive regulation of translational initiation (GO:0045948)3.87879520
45positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.82687762
46positive regulation of natural killer cell mediated immunity (GO:0002717)3.81564127
47positive regulation of interleukin-8 secretion (GO:2000484)3.81275346
48cellular defense response (GO:0006968)3.78300455
49regulation of viral genome replication (GO:0045069)3.73673662
50regulation of regulatory T cell differentiation (GO:0045589)3.71654629
51thymic T cell selection (GO:0045061)3.71049615
52positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.69684485
53regulation of memory T cell differentiation (GO:0043380)3.68537807
54positive regulation of T cell migration (GO:2000406)3.66468814
55regulation of B cell receptor signaling pathway (GO:0050855)3.64353401
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59791359
57positive regulation of lymphocyte apoptotic process (GO:0070230)3.56927196
58gonadal mesoderm development (GO:0007506)3.55792131
59neutrophil activation (GO:0042119)3.53673859
60T cell costimulation (GO:0031295)3.51471412
61dendritic cell migration (GO:0036336)3.51333341
62regulation of T cell receptor signaling pathway (GO:0050856)3.50398361
63lymphocyte costimulation (GO:0031294)3.46844394
64positive regulation of viral genome replication (GO:0045070)3.46701010
65regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.43392017
66regulation of natural killer cell mediated immunity (GO:0002715)3.43392017
67T cell receptor signaling pathway (GO:0050852)3.42396782
68positive regulation of cell killing (GO:0031343)3.40898392
69regulation of interleukin-2 biosynthetic process (GO:0045076)3.40189497
70lymphocyte migration (GO:0072676)3.39578305
71negative regulation of B cell proliferation (GO:0030889)3.38269604
72positive regulation of tolerance induction (GO:0002645)3.36709070
73regulation of tolerance induction (GO:0002643)3.35244105
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.35123069
75regulation of T cell migration (GO:2000404)3.35097721
76T cell apoptotic process (GO:0070231)3.34622887
77regulation of leukocyte mediated cytotoxicity (GO:0001910)3.32790978
78DNA demethylation (GO:0080111)3.32399425
79nucleoside diphosphate catabolic process (GO:0009134)3.30036254
80regulation of lymphocyte migration (GO:2000401)3.29330177
81cytolysis (GO:0019835)3.28950990
82chemokine-mediated signaling pathway (GO:0070098)3.28036102
83T cell selection (GO:0045058)3.25023690
84positive regulation of activated T cell proliferation (GO:0042104)3.24306308
85regulation of calcium-mediated signaling (GO:0050848)3.23581902
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21692936
87negative regulation of viral process (GO:0048525)3.20788049
88negative regulation of lymphocyte apoptotic process (GO:0070229)3.20716270
89regulation of granulocyte chemotaxis (GO:0071622)3.20432883
90sequestering of actin monomers (GO:0042989)3.16318660
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16258223
92T cell mediated immunity (GO:0002456)3.15866691
93regulation of T cell mediated cytotoxicity (GO:0001914)3.14250752
94regulation of gamma-delta T cell differentiation (GO:0045586)3.12531383
95regulation of cell killing (GO:0031341)3.11865274
96cellular response to nicotine (GO:0071316)3.07423307
97cytidine catabolic process (GO:0006216)10.5725754
98cytidine deamination (GO:0009972)10.5725754
99cytidine metabolic process (GO:0046087)10.5725754
100pyrimidine ribonucleoside catabolic process (GO:0046133)10.0459233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.04916485
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.03994150
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.37473613
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28185927
5MYB_26560356_Chip-Seq_TH2_Human3.19417640
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92711817
7RUNX_20019798_ChIP-Seq_JUKART_Human2.77006898
8GATA1_22025678_ChIP-Seq_K562_Human2.67072530
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61544883
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57904588
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56350272
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52203732
13GATA3_27048872_Chip-Seq_THYMUS_Human2.26443536
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25539152
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21361830
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.18830796
17MYB_26560356_Chip-Seq_TH1_Human2.10116136
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09476605
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08779323
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02399852
21BP1_19119308_ChIP-ChIP_Hs578T_Human13.5312534
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96550874
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85705169
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84095697
25GATA3_26560356_Chip-Seq_TH2_Human1.82179788
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75340627
27HTT_18923047_ChIP-ChIP_STHdh_Human1.74615195
28UTX_26944678_Chip-Seq_JUKART_Human1.72569433
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67961335
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60365271
31MAF_26560356_Chip-Seq_TH2_Human1.55824712
32MAF_26560356_Chip-Seq_TH1_Human1.53286211
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45459878
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43443723
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41708376
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38957934
37IGF1R_20145208_ChIP-Seq_DFB_Human1.35206616
38VDR_23849224_ChIP-Seq_CD4+_Human1.31806721
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26698447
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.25175901
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23771647
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21395215
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21360750
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18335501
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.11651509
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11414125
47BCL6_27268052_Chip-Seq_Bcells_Human1.06965991
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05126409
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03192424
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00641536
51TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99278600
52SPI1_23547873_ChIP-Seq_NB4_Human0.97167011
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95444469
54GATA3_26560356_Chip-Seq_TH1_Human0.95423558
55ZNF274_21170338_ChIP-Seq_K562_Hela0.93594510
56FOXP3_21729870_ChIP-Seq_TREG_Human0.92804045
57SRF_21415370_ChIP-Seq_HL-1_Mouse0.92518242
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89767934
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89447037
60CTCF_20526341_ChIP-Seq_ESCs_Human0.88234447
61NOTCH1_21737748_ChIP-Seq_TLL_Human0.86899448
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85697283
63NANOG_20526341_ChIP-Seq_ESCs_Human0.85294196
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85081674
65GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82937706
66TP53_22573176_ChIP-Seq_HFKS_Human0.81350017
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81252491
68RXR_22108803_ChIP-Seq_LS180_Human0.80622194
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78286005
70TAF2_19829295_ChIP-Seq_ESCs_Human0.77720935
71P300_27268052_Chip-Seq_Bcells_Human0.77097563
72BCOR_27268052_Chip-Seq_Bcells_Human0.76972549
73GABP_17652178_ChIP-ChIP_JURKAT_Human0.76593335
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74799154
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74458544
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74049956
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.74041854
78FOXH1_21741376_ChIP-Seq_ESCs_Human0.73824174
79BCAT_22108803_ChIP-Seq_LS180_Human0.73642143
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.73314438
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.72439175
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72061975
83SA1_27219007_Chip-Seq_Bcells_Human0.69492583
84MYC_19829295_ChIP-Seq_ESCs_Human0.68340388
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.66297537
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.66178958
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66106366
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.66066770
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.64866879
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64215984
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.63398273
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62495839
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.61879404
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.61801976
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61301639
96OCT4_20526341_ChIP-Seq_ESCs_Human0.60865358
97NANOG_19829295_ChIP-Seq_ESCs_Human0.60387634
98SOX2_19829295_ChIP-Seq_ESCs_Human0.60387634
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.59037959
100AR_21572438_ChIP-Seq_LNCaP_Human0.58865175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.56814027
2MP0003763_abnormal_thymus_physiology4.10555040
3MP0006082_CNS_inflammation3.93913146
4MP0000372_irregular_coat_pigmentation3.30757347
5MP0009785_altered_susceptibility_to3.24815655
6MP0002148_abnormal_hypersensitivity_rea3.24715171
7MP0001835_abnormal_antigen_presentation3.20262366
8MP0005000_abnormal_immune_tolerance2.95106445
9MP0001800_abnormal_humoral_immune2.90528109
10MP0002723_abnormal_immune_serum2.79460657
11MP0002277_abnormal_respiratory_mucosa2.60816618
12MP0002420_abnormal_adaptive_immunity2.59610276
13MP0001819_abnormal_immune_cell2.51576764
14MP0003045_fibrosis2.51282770
15MP0009333_abnormal_splenocyte_physiolog2.44743564
16MP0005025_abnormal_response_to2.27978930
17MP0002398_abnormal_bone_marrow2.27553126
18MP0003866_abnormal_defecation2.19103595
19MP0001790_abnormal_immune_system2.17981942
20MP0005387_immune_system_phenotype2.17981942
21MP0002452_abnormal_antigen_presenting2.15876865
22MP0010307_abnormal_tumor_latency2.15805664
23MP0010155_abnormal_intestine_physiology2.15796871
24MP0001873_stomach_inflammation2.14395613
25MP0002166_altered_tumor_susceptibility2.08578197
26MP0000716_abnormal_immune_system2.00013163
27MP0005451_abnormal_body_composition1.86769424
28MP0003448_altered_tumor_morphology1.86733702
29MP0002163_abnormal_gland_morphology1.80013999
30MP0003436_decreased_susceptibility_to1.79974700
31MP0002006_tumorigenesis1.67229249
32MP0000685_abnormal_immune_system1.66828747
33MP0000703_abnormal_thymus_morphology1.66030221
34MP0001919_abnormal_reproductive_system1.62913761
35MP0002405_respiratory_system_inflammati1.60592765
36MP0005310_abnormal_salivary_gland1.59341548
37MP0002419_abnormal_innate_immunity1.58137638
38MP0002429_abnormal_blood_cell1.57039158
39MP0002722_abnormal_immune_system1.53902431
40MP0003786_premature_aging1.53694855
41MP0000689_abnormal_spleen_morphology1.48018705
42MP0002877_abnormal_melanocyte_morpholog1.47473500
43MP0000465_gastrointestinal_hemorrhage1.47371439
44MP0002933_joint_inflammation1.44018745
45MP0004145_abnormal_muscle_electrophysio1.41728180
46MP0002876_abnormal_thyroid_physiology1.41264403
47MP0001845_abnormal_inflammatory_respons1.39419906
48MP0009763_increased_sensitivity_to1.34021302
49MP0005623_abnormal_meninges_morphology1.27939252
50MP0008469_abnormal_protein_level1.22913503
51MP0001853_heart_inflammation1.22263295
52MP0009765_abnormal_xenobiotic_induced1.21070024
53MP0001188_hyperpigmentation1.17106506
54MP0003646_muscle_fatigue1.15198629
55MP0004381_abnormal_hair_follicle1.12539428
56MP0005360_urolithiasis1.11874796
57MP0005389_reproductive_system_phenotype1.10453515
58MP0005464_abnormal_platelet_physiology1.08639865
59MP0000920_abnormal_myelination1.06517147
60MP0002168_other_aberrant_phenotype1.05293270
61MP0005166_decreased_susceptibility_to0.99224698
62MP0002019_abnormal_tumor_incidence0.98413619
63MP0003724_increased_susceptibility_to0.95724405
64MP0001542_abnormal_bone_strength0.92014543
65MP0005379_endocrine/exocrine_gland_phen0.91634840
66MP0008872_abnormal_physiological_respon0.91295121
67MP0002009_preneoplasia0.88059857
68MP0001533_abnormal_skeleton_physiology0.83277794
69MP0008877_abnormal_DNA_methylation0.82812592
70MP0004947_skin_inflammation0.81857714
71MP0000343_altered_response_to0.80789304
72MP0002095_abnormal_skin_pigmentation0.78858269
73MP0003806_abnormal_nucleotide_metabolis0.77088691
74MP0009643_abnormal_urine_homeostasis0.75452708
75MP0001346_abnormal_lacrimal_gland0.74328372
76MP0002693_abnormal_pancreas_physiology0.71999075
77MP0001666_abnormal_nutrient_absorption0.71743251
78MP0003693_abnormal_embryo_hatching0.71737708
79MP0006276_abnormal_autonomic_nervous0.70859676
80MP0003075_altered_response_to0.68851582
81MP0001727_abnormal_embryo_implantation0.65274490
82MP0001765_abnormal_ion_homeostasis0.64997777
83MP0005584_abnormal_enzyme/coenzyme_acti0.59943106
84MP0004147_increased_porphyrin_level0.59261972
85MP0000604_amyloidosis0.58382952
86MP0009745_abnormal_behavioral_response0.57791932
87MP0008873_increased_physiological_sensi0.57621887
88MP0003329_amyloid_beta_deposits0.56849065
89MP0005410_abnormal_fertilization0.56705524
90MP0006072_abnormal_retinal_apoptosis0.55652994
91MP0009379_abnormal_foot_pigmentation0.54704274
92MP0003300_gastrointestinal_ulcer0.52406831
93MP0002909_abnormal_adrenal_gland0.51722586
94MP0005075_abnormal_melanosome_morpholog0.51468582
95MP0001191_abnormal_skin_condition0.51123669
96MP0000858_altered_metastatic_potential0.48998855
97MP0005332_abnormal_amino_acid0.47488211
98MP0005636_abnormal_mineral_homeostasis0.46194412
99MP0005319_abnormal_enzyme/_coenzyme0.45134585
100MP0004043_abnormal_pH_regulation0.44450095

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)9.37639234
2Hypoproteinemia (HP:0003075)6.00919694
3Chronic diarrhea (HP:0002028)5.48233547
4Abnormality of T cells (HP:0002843)5.44248404
5IgG deficiency (HP:0004315)5.40359886
6Stomatitis (HP:0010280)5.17545008
7Recurrent viral infections (HP:0004429)4.38563229
8Severe combined immunodeficiency (HP:0004430)4.37412976
9Cutaneous melanoma (HP:0012056)4.26153090
10IgA deficiency (HP:0002720)3.99970124
11Aplastic anemia (HP:0001915)3.97698546
12Abnormality of eosinophils (HP:0001879)3.94898187
13Recurrent cutaneous fungal infections (HP:0011370)3.74345658
14Chronic mucocutaneous candidiasis (HP:0002728)3.74345658
15Recurrent fungal infections (HP:0002841)3.62101281
16Autoimmune hemolytic anemia (HP:0001890)3.50846874
17Hypoplasia of the thymus (HP:0000778)3.45925100
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.41818497
19Combined immunodeficiency (HP:0005387)3.40066374
20Increased IgM level (HP:0003496)3.36809245
21Hemiplegia (HP:0002301)3.36507903
22Hypoalbuminemia (HP:0003073)3.31352748
23Abnormal albumin level (HP:0012116)3.31352748
24Thyroiditis (HP:0100646)3.26208938
25Squamous cell carcinoma (HP:0002860)3.24855161
26Eosinophilia (HP:0001880)3.23901933
27Elevated erythrocyte sedimentation rate (HP:0003565)3.21219988
28Abnormality of the prostate (HP:0008775)3.18621778
29Pustule (HP:0200039)3.14723174
30Encephalitis (HP:0002383)3.12426835
31Leukocytosis (HP:0001974)3.10668669
32Entropion (HP:0000621)3.09492825
33Meningitis (HP:0001287)3.08325671
34Ureteral stenosis (HP:0000071)3.05255592
35Agammaglobulinemia (HP:0004432)2.95891311
36Joint swelling (HP:0001386)2.90549190
37IgM deficiency (HP:0002850)2.87537728
38Ureteral obstruction (HP:0006000)2.86753749
39Recurrent corneal erosions (HP:0000495)2.86264254
40Abnormality of macrophages (HP:0004311)2.85514899
41Oral leukoplakia (HP:0002745)2.84756445
42Granulocytopenia (HP:0001913)2.80155836
43Recurrent bronchitis (HP:0002837)2.79610371
44Keratitis (HP:0000491)2.68519516
45Tetraplegia (HP:0002445)2.66425473
46Chronic obstructive pulmonary disease (HP:0006510)2.58672501
47Obstructive lung disease (HP:0006536)2.58672501
48Renal cortical cysts (HP:0000803)2.52178186
49Increased CSF protein (HP:0002922)2.51181930
50Increased intramyocellular lipid droplets (HP:0012240)2.47883225
51Pulmonary infiltrates (HP:0002113)2.40801818
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39687644
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37426424
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37426424
55Arthropathy (HP:0003040)2.34095982
56Poikiloderma (HP:0001029)2.31501675
57Fetal akinesia sequence (HP:0001989)2.29289271
58Gastrointestinal infarctions (HP:0005244)2.28787315
59Gangrene (HP:0100758)2.26602612
60Basal cell carcinoma (HP:0002671)2.25385711
61Hemoptysis (HP:0002105)2.23208057
62Melanoma (HP:0002861)2.21401470
63Episodic fever (HP:0001954)2.17653268
64Amniotic constriction ring (HP:0009775)2.13245970
65Abnormality of placental membranes (HP:0011409)2.13245970
66Abnormality of T cell physiology (HP:0011840)2.12705911
67Abnormality of oral frenula (HP:0000190)2.10137188
68Chest pain (HP:0100749)2.09868679
69Increased serum ferritin (HP:0003281)2.09237797
70Acute hepatic failure (HP:0006554)2.09050301
71Panhypogammaglobulinemia (HP:0003139)2.05775806
72Increased muscle lipid content (HP:0009058)2.04352492
73Recurrent skin infections (HP:0001581)2.03201978
74Progressive inability to walk (HP:0002505)2.02270566
75Autoimmune thrombocytopenia (HP:0001973)2.01820688
763-Methylglutaconic aciduria (HP:0003535)2.00257498
77Hepatosplenomegaly (HP:0001433)2.00140342
78Abnormality of dental color (HP:0011073)2.00057355
79T lymphocytopenia (HP:0005403)10.1741509
80Renal Fanconi syndrome (HP:0001994)1.98315888
81Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96923454
82Autoamputation (HP:0001218)1.96713552
83Neonatal respiratory distress (HP:0002643)1.93794741
84Abnormality of the pleura (HP:0002103)1.92865443
85Radial bowing (HP:0002986)1.91920094
86Anhidrosis (HP:0000970)1.91202946
87Abnormality of DNA repair (HP:0003254)1.89842238
88Skin rash (HP:0000988)1.87870455
89Pulmonary fibrosis (HP:0002206)1.87337832
90Abnormal spermatogenesis (HP:0008669)1.86598369
91Lymphoma (HP:0002665)1.86040329
92Testicular atrophy (HP:0000029)1.85884235
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.82079630
94Mediastinal lymphadenopathy (HP:0100721)1.79574621
95Erythroderma (HP:0001019)1.78880095
96Sensory axonal neuropathy (HP:0003390)1.78092525
97J-shaped sella turcica (HP:0002680)1.77847863
98Abnormality of male internal genitalia (HP:0000022)1.74945448
99Eczematoid dermatitis (HP:0000976)1.70945108
100Pancytopenia (HP:0001876)1.70329276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.18242960
2KDR4.04353420
3ITK3.56814455
4NTRK13.13924743
5MATK2.98690100
6DAPK22.89133475
7CAMKK22.59154411
8MAP3K112.53475127
9BCKDK2.46504380
10MAP4K12.12145748
11MAP4K22.07510111
12TEC2.06845589
13GRK62.04895469
14WNK42.04688955
15NME11.97207354
16TESK21.96481279
17BMPR21.84029334
18LCK1.83109554
19PRKCQ1.76507199
20CSK1.70064640
21GRK71.64382609
22ADRBK21.60546272
23SYK1.59503700
24RIPK41.48743376
25PIM11.48138511
26PIM21.42642755
27MAPK111.41410097
28BCR1.33583772
29BTK1.32406132
30PIK3CA1.24512830
31CAMKK11.17402236
32FES1.11871681
33MAP3K71.08869963
34MAP3K141.07894111
35ZAP701.04108726
36MARK31.02753826
37IKBKB1.01607687
38FGFR11.00183122
39MAPKAPK30.97799069
40IKBKE0.96810557
41STK100.91197954
42MAP3K60.89172496
43NUAK10.86080232
44ARAF0.83460534
45STK390.81873275
46BRSK10.81371304
47TLK10.80565670
48ERBB20.78359386
49BUB10.78002132
50PIK3CG0.75175401
51MAPK130.74780182
52GRK10.70859269
53TYRO30.68290728
54LYN0.67440237
55FYN0.67434176
56JAK20.60401424
57PLK20.52753939
58INSR0.49328453
59TAOK30.47635196
60SRPK10.46877839
61PDK20.46142202
62MAPKAPK20.45865748
63LIMK10.44116479
64AURKA0.43548566
65VRK10.41369891
66ZAK0.41330791
67BLK0.41127165
68TESK10.41119328
69PRKCE0.39767346
70CLK10.36331809
71PINK10.35808991
72PRKCA0.35672182
73OXSR10.32607913
74PRKCD0.30612761
75CCNB10.30373497
76TBK10.29882678
77CAMK2G0.29057885
78OBSCN0.28980077
79RPS6KA50.28092683
80TYK20.28018026
81CAMK2A0.25859273
82PRKACA0.25605732
83TRPM70.25410639
84FRK0.24676942
85GRK50.24023836
86INSRR0.23927731
87PRKCB0.22777024
88TGFBR20.21816617
89HCK0.20971843
90CAMK2D0.20947531
91JAK30.20790296
92CSNK1A10.20695936
93TTK0.20358199
94ATR0.19655700
95MAP3K130.19254847
96CSNK1A1L0.18759002
97STK160.18159240
98IGF1R0.17700421
99SCYL20.17660446
100TAOK20.17564640

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.60920876
2Autoimmune thyroid disease_Homo sapiens_hsa053204.33355339
3Graft-versus-host disease_Homo sapiens_hsa053323.96145184
4Allograft rejection_Homo sapiens_hsa053303.92926910
5Antigen processing and presentation_Homo sapiens_hsa046123.71819038
6Proteasome_Homo sapiens_hsa030503.27594442
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.24973043
8Type I diabetes mellitus_Homo sapiens_hsa049402.96730591
9T cell receptor signaling pathway_Homo sapiens_hsa046602.95792861
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.94537859
11Hematopoietic cell lineage_Homo sapiens_hsa046402.80677669
12Rheumatoid arthritis_Homo sapiens_hsa053232.40232054
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21750720
14Measles_Homo sapiens_hsa051622.14241234
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85604246
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80903784
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.63511721
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43639282
19Viral myocarditis_Homo sapiens_hsa054161.37339280
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35632520
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29340154
22Oxidative phosphorylation_Homo sapiens_hsa001901.21009881
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16681365
24Prion diseases_Homo sapiens_hsa050201.14977209
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.12569861
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09031791
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.08903995
28Salmonella infection_Homo sapiens_hsa051321.03049446
29Staphylococcus aureus infection_Homo sapiens_hsa051501.00337591
30Parkinsons disease_Homo sapiens_hsa050120.93540385
31Chemokine signaling pathway_Homo sapiens_hsa040620.87600662
32Linoleic acid metabolism_Homo sapiens_hsa005910.87489502
33RNA polymerase_Homo sapiens_hsa030200.83330271
34Asthma_Homo sapiens_hsa053100.81666100
35Protein export_Homo sapiens_hsa030600.80637788
36N-Glycan biosynthesis_Homo sapiens_hsa005100.80095679
37Apoptosis_Homo sapiens_hsa042100.79912738
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76099299
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75951868
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75484860
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74327558
42Homologous recombination_Homo sapiens_hsa034400.73237231
43Shigellosis_Homo sapiens_hsa051310.72240754
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70780171
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63014037
46Pyrimidine metabolism_Homo sapiens_hsa002400.62304214
47Herpes simplex infection_Homo sapiens_hsa051680.60629359
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56518560
49Nucleotide excision repair_Homo sapiens_hsa034200.55631920
50Alzheimers disease_Homo sapiens_hsa050100.52105030
51Influenza A_Homo sapiens_hsa051640.51086201
52Systemic lupus erythematosus_Homo sapiens_hsa053220.49613749
53Phototransduction_Homo sapiens_hsa047440.49454211
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49400061
55Endocytosis_Homo sapiens_hsa041440.49072564
56Folate biosynthesis_Homo sapiens_hsa007900.48033168
57African trypanosomiasis_Homo sapiens_hsa051430.47565605
58Fanconi anemia pathway_Homo sapiens_hsa034600.47252182
59Ether lipid metabolism_Homo sapiens_hsa005650.45027635
60TNF signaling pathway_Homo sapiens_hsa046680.43109468
61p53 signaling pathway_Homo sapiens_hsa041150.41859447
62Caffeine metabolism_Homo sapiens_hsa002320.40182247
63Leishmaniasis_Homo sapiens_hsa051400.39982315
64Osteoclast differentiation_Homo sapiens_hsa043800.39560057
65HTLV-I infection_Homo sapiens_hsa051660.38650351
66Sulfur metabolism_Homo sapiens_hsa009200.38622590
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38585246
68Lysosome_Homo sapiens_hsa041420.37063095
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36035160
70Tuberculosis_Homo sapiens_hsa051520.34011033
71Chemical carcinogenesis_Homo sapiens_hsa052040.33752456
72DNA replication_Homo sapiens_hsa030300.32748686
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32743248
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.31602991
75Nitrogen metabolism_Homo sapiens_hsa009100.28857233
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27933364
77Malaria_Homo sapiens_hsa051440.27658504
78Peroxisome_Homo sapiens_hsa041460.27294025
79Fatty acid biosynthesis_Homo sapiens_hsa000610.26496205
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25591590
81Huntingtons disease_Homo sapiens_hsa050160.24690956
82Epstein-Barr virus infection_Homo sapiens_hsa051690.24385243
83Purine metabolism_Homo sapiens_hsa002300.21982439
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21926856
85One carbon pool by folate_Homo sapiens_hsa006700.21790167
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.21252295
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20191837
88Olfactory transduction_Homo sapiens_hsa047400.19435205
89Arachidonic acid metabolism_Homo sapiens_hsa005900.15457347
90Selenocompound metabolism_Homo sapiens_hsa004500.15116802
91Cardiac muscle contraction_Homo sapiens_hsa042600.14293526
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.13749063
93Propanoate metabolism_Homo sapiens_hsa006400.13560517
94Mismatch repair_Homo sapiens_hsa034300.11284519
95VEGF signaling pathway_Homo sapiens_hsa043700.11183194
96Toxoplasmosis_Homo sapiens_hsa051450.10407437
97Collecting duct acid secretion_Homo sapiens_hsa049660.10241193
98Viral carcinogenesis_Homo sapiens_hsa052030.09981358
99Amphetamine addiction_Homo sapiens_hsa050310.07394772
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.07374021

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