TRAJ47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.55290555
2negative regulation by host of viral transcription (GO:0043922)9.48842221
3pyrimidine ribonucleoside catabolic process (GO:0046133)8.93230785
4eosinophil migration (GO:0072677)8.60410808
5DNA deamination (GO:0045006)8.49294914
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.84479750
7regulation of lymphocyte chemotaxis (GO:1901623)7.48425508
8monocyte chemotaxis (GO:0002548)7.07318341
9regulation of chronic inflammatory response (GO:0002676)6.82758274
10macrophage chemotaxis (GO:0048246)6.79338684
11regulation of activation of Janus kinase activity (GO:0010533)6.55713231
12regulation of regulatory T cell differentiation (GO:0045589)6.38082607
13regulation of chemokine-mediated signaling pathway (GO:0070099)6.33771109
14positive regulation of T cell apoptotic process (GO:0070234)6.28139840
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.19495046
16positive regulation of natural killer cell mediated immunity (GO:0002717)6.16548066
17negative regulation of T cell apoptotic process (GO:0070233)6.12920018
18regulation of mononuclear cell migration (GO:0071675)6.11448728
19positive regulation of T cell chemotaxis (GO:0010820)6.03357846
20regulation of T cell chemotaxis (GO:0010819)6.03357846
21positive regulation of monocyte chemotaxis (GO:0090026)5.98345341
22positive regulation of interleukin-8 secretion (GO:2000484)5.83987319
23positive regulation of lymphocyte migration (GO:2000403)5.55978448
24regulation of macrophage chemotaxis (GO:0010758)5.50589538
25positive thymic T cell selection (GO:0045059)5.45588780
26modulation by host of symbiont transcription (GO:0052472)5.21024593
27modulation by host of viral transcription (GO:0043921)5.21024593
28negative regulation of viral transcription (GO:0032897)5.11822775
29positive regulation of lymphocyte apoptotic process (GO:0070230)5.09360201
30regulation of natural killer cell mediated immunity (GO:0002715)5.08570877
31regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.08570877
32positive T cell selection (GO:0043368)5.08287195
33regulation of T cell tolerance induction (GO:0002664)5.00716100
34cellular response to interleukin-15 (GO:0071350)4.94917409
35modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.94069609
36response to interleukin-15 (GO:0070672)4.86742352
37positive regulation of tolerance induction (GO:0002645)4.83966495
38positive regulation of translational initiation (GO:0045948)4.82010445
39membrane raft organization (GO:0031579)4.70854817
40positive regulation of calcium-mediated signaling (GO:0050850)4.62850128
41dendritic cell chemotaxis (GO:0002407)4.46526714
42positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.37569733
43negative regulation of B cell proliferation (GO:0030889)4.26222000
44regulation of lymphocyte migration (GO:2000401)4.24448443
45regulation of T cell apoptotic process (GO:0070232)4.24266279
46positive regulation of leukocyte apoptotic process (GO:2000108)4.19583563
47regulation of interleukin-2 biosynthetic process (GO:0045076)4.15684000
48negative regulation of T cell receptor signaling pathway (GO:0050860)4.14950560
49negative regulation of lymphocyte apoptotic process (GO:0070229)4.09063602
50negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.05577269
51regulation of tolerance induction (GO:0002643)4.05330411
52regulation of interleukin-12 biosynthetic process (GO:0045075)4.04669459
53granulocyte activation (GO:0036230)4.03485915
54negative regulation of viral genome replication (GO:0045071)4.01735480
55regulation of monocyte chemotaxis (GO:0090025)4.00014535
56regulation of interleukin-8 secretion (GO:2000482)3.97100205
57localization within membrane (GO:0051668)3.96770714
58positive regulation of cell killing (GO:0031343)3.92315380
59pyrimidine nucleoside catabolic process (GO:0046135)3.89284714
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81336268
61negative regulation of B cell activation (GO:0050869)3.78867493
62positive regulation of gamma-delta T cell activation (GO:0046645)3.72391648
63sarcoplasmic reticulum calcium ion transport (GO:0070296)3.72223696
64positive regulation of T cell migration (GO:2000406)3.65866376
65nucleoside diphosphate catabolic process (GO:0009134)3.64045644
66thymic T cell selection (GO:0045061)3.62785415
67dendritic cell migration (GO:0036336)3.61531411
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55870951
69T cell costimulation (GO:0031295)3.55107860
70regulation of cell killing (GO:0031341)3.54309850
71lymphocyte costimulation (GO:0031294)3.50414294
72modification by host of symbiont morphology or physiology (GO:0051851)3.45764203
73negative regulation of T cell differentiation in thymus (GO:0033085)3.43732614
74positive regulation of macrophage differentiation (GO:0045651)3.43385918
75regulation of calcium-mediated signaling (GO:0050848)3.42392889
76regulation of gamma-delta T cell differentiation (GO:0045586)3.41637809
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40089143
78regulation of T cell migration (GO:2000404)3.37393798
79negative regulation of T cell activation (GO:0050868)3.32709929
80regulation of homotypic cell-cell adhesion (GO:0034110)3.30955216
81negative regulation of T cell differentiation (GO:0045581)3.30674322
82regulation of T cell receptor signaling pathway (GO:0050856)3.29423209
83DNA demethylation (GO:0080111)3.24996153
84T cell selection (GO:0045058)3.22910432
85regulation of lymphocyte apoptotic process (GO:0070228)3.21468402
86interaction with symbiont (GO:0051702)3.17539877
87positive regulation of smooth muscle cell migration (GO:0014911)3.13394447
88negative regulation of viral process (GO:0048525)3.13065441
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.12275126
90regulation of B cell receptor signaling pathway (GO:0050855)3.09804078
91T cell migration (GO:0072678)3.08457950
92positive regulation of cell adhesion mediated by integrin (GO:0033630)3.07084897
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02189699
94actin nucleation (GO:0045010)3.02129202
95negative regulation of leukocyte apoptotic process (GO:2000107)2.98735374
96negative regulation of lymphocyte activation (GO:0051250)2.96715087
97histone mRNA catabolic process (GO:0071044)2.94920972
98cytidine catabolic process (GO:0006216)10.1608111
99cytidine deamination (GO:0009972)10.1608111
100cytidine metabolic process (GO:0046087)10.1608111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.54520851
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.73493411
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.31478846
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64049817
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44877094
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09024764
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84914570
8STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73748104
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.63764974
10MYB_26560356_Chip-Seq_TH2_Human2.44609797
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.37822277
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15436891
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13336443
14RUNX_20019798_ChIP-Seq_JUKART_Human2.06249326
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04920444
16GATA3_27048872_Chip-Seq_THYMUS_Human2.00107831
17BP1_19119308_ChIP-ChIP_Hs578T_Human14.3383113
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77890393
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65765960
20MAF_26560356_Chip-Seq_TH2_Human1.63329983
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63039412
22MYB_26560356_Chip-Seq_TH1_Human1.60245095
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56844883
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56093119
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52327272
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51681220
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49293316
28VDR_22108803_ChIP-Seq_LS180_Human1.44641157
29HTT_18923047_ChIP-ChIP_STHdh_Human1.43181623
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41859728
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37273025
32GATA3_26560356_Chip-Seq_TH2_Human1.34219945
33UTX_26944678_Chip-Seq_JUKART_Human1.26302801
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23136311
35MAF_26560356_Chip-Seq_TH1_Human1.22732970
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21403311
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.20029956
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16566480
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15372841
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13816841
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.09534530
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.08085964
43GATA3_26560356_Chip-Seq_TH1_Human1.07274237
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05526008
45TAF2_19829295_ChIP-Seq_ESCs_Human1.04899655
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04853309
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02260083
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01070543
49GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00188414
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97470268
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96895924
52BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95385778
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91995795
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91787777
55TAF15_26573619_Chip-Seq_HEK293_Human0.88550183
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.87486114
57FOXP3_21729870_ChIP-Seq_TREG_Human0.87067576
58TP53_22573176_ChIP-Seq_HFKS_Human0.86214905
59VDR_23849224_ChIP-Seq_CD4+_Human0.85738236
60ELF1_20517297_ChIP-Seq_JURKAT_Human0.84360801
61SPI1_23547873_ChIP-Seq_NB4_Human0.82596156
62FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82034926
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80510135
64SOX2_19829295_ChIP-Seq_ESCs_Human0.80074689
65NANOG_19829295_ChIP-Seq_ESCs_Human0.80074689
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78628457
67RBPJ_21746931_ChIP-Seq_IB4_Human0.78384915
68FOXH1_21741376_ChIP-Seq_EPCs_Human0.77192782
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75288922
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75253036
71BCAT_22108803_ChIP-Seq_LS180_Human0.74489581
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73835494
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.73300336
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71742652
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71703314
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71401275
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69824700
78TP53_16413492_ChIP-PET_HCT116_Human0.68943686
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68764732
80P300_27268052_Chip-Seq_Bcells_Human0.67482251
81TP53_18474530_ChIP-ChIP_U2OS_Human0.66503948
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.66305946
83HNFA_21074721_ChIP-Seq_CACO-2_Human0.66279216
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.66196306
85CTCF_18555785_Chip-Seq_ESCs_Mouse0.65562180
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.64812797
87CEBPB_22108803_ChIP-Seq_LS180_Human0.64597055
88PHF8_20622853_ChIP-Seq_HELA_Human0.63823572
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63614832
90SA1_27219007_Chip-Seq_Bcells_Human0.61752796
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.61408860
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.61315303
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.60082457
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.59758664
95NANOG_20526341_ChIP-Seq_ESCs_Human0.58551432
96STAT1_20625510_ChIP-Seq_HELA_Human0.58188913
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.56944083
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.56898344
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56863450
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.56752422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.38415728
2MP0006082_CNS_inflammation4.56231996
3MP0003763_abnormal_thymus_physiology3.93164698
4MP0001873_stomach_inflammation3.60473856
5MP0009333_abnormal_splenocyte_physiolog3.34700980
6MP0002148_abnormal_hypersensitivity_rea2.89202948
7MP0001188_hyperpigmentation2.75328129
8MP0009785_altered_susceptibility_to2.65992202
9MP0005000_abnormal_immune_tolerance2.56644165
10MP0001800_abnormal_humoral_immune2.48011808
11MP0002723_abnormal_immune_serum2.43125697
12MP0004145_abnormal_muscle_electrophysio2.42817845
13MP0003866_abnormal_defecation2.37685932
14MP0010307_abnormal_tumor_latency2.31718114
15MP0002163_abnormal_gland_morphology2.24700138
16MP0001835_abnormal_antigen_presentation2.20377240
17MP0002405_respiratory_system_inflammati2.19650909
18MP0001790_abnormal_immune_system2.17739288
19MP0005387_immune_system_phenotype2.17739288
20MP0002420_abnormal_adaptive_immunity2.17304229
21MP0010155_abnormal_intestine_physiology2.16054828
22MP0003786_premature_aging2.13778626
23MP0001819_abnormal_immune_cell2.12204391
24MP0000569_abnormal_digit_pigmentation2.10067662
25MP0002398_abnormal_bone_marrow1.94165859
26MP0005025_abnormal_response_to1.91572561
27MP0002877_abnormal_melanocyte_morpholog1.90570745
28MP0002933_joint_inflammation1.90045896
29MP0000716_abnormal_immune_system1.83330278
30MP0003045_fibrosis1.78699808
31MP0002452_abnormal_antigen_presenting1.71249676
32MP0001853_heart_inflammation1.67746225
33MP0002722_abnormal_immune_system1.66912741
34MP0002138_abnormal_hepatobiliary_system1.65684625
35MP0008007_abnormal_cellular_replicative1.61865047
36MP0000703_abnormal_thymus_morphology1.61766674
37MP0005670_abnormal_white_adipose1.61577016
38MP0005464_abnormal_platelet_physiology1.61013837
39MP0000689_abnormal_spleen_morphology1.58299902
40MP0003075_altered_response_to1.54334122
41MP0005310_abnormal_salivary_gland1.50465831
42MP0001984_abnormal_olfaction1.49220713
43MP0001845_abnormal_inflammatory_respons1.47789948
44MP0002638_abnormal_pupillary_reflex1.44794454
45MP0005379_endocrine/exocrine_gland_phen1.42487587
46MP0002429_abnormal_blood_cell1.39878287
47MP0001502_abnormal_circadian_rhythm1.37417158
48MP0001905_abnormal_dopamine_level1.35121658
49MP0003878_abnormal_ear_physiology1.32149698
50MP0005377_hearing/vestibular/ear_phenot1.32149698
51MP0003448_altered_tumor_morphology1.27131798
52MP0005075_abnormal_melanosome_morpholog1.25006128
53MP0001661_extended_life_span1.22122907
54MP0000920_abnormal_myelination1.18992729
55MP0002419_abnormal_innate_immunity1.15697191
56MP0005174_abnormal_tail_pigmentation1.15339018
57MP0003183_abnormal_peptide_metabolism1.12737002
58MP0008873_increased_physiological_sensi1.02394986
59MP0008469_abnormal_protein_level1.01038672
60MP0002277_abnormal_respiratory_mucosa0.98876736
61MP0000685_abnormal_immune_system0.92949408
62MP0004381_abnormal_hair_follicle0.90319628
63MP0002909_abnormal_adrenal_gland0.87965575
64MP0002234_abnormal_pharynx_morphology0.84392512
65MP0004947_skin_inflammation0.81202545
66MP0004147_increased_porphyrin_level0.78746643
67MP0009763_increased_sensitivity_to0.78542569
68MP0004043_abnormal_pH_regulation0.76899324
69MP0009765_abnormal_xenobiotic_induced0.74845761
70MP0005645_abnormal_hypothalamus_physiol0.74583015
71MP0000372_irregular_coat_pigmentation0.71804278
72MP0001485_abnormal_pinna_reflex0.71188104
73MP0003137_abnormal_impulse_conducting0.68529570
74MP0003567_abnormal_fetal_cardiomyocyte0.67133552
75MP0002693_abnormal_pancreas_physiology0.65410087
76MP0005165_increased_susceptibility_to0.63565849
77MP0000343_altered_response_to0.63048917
78MP0000516_abnormal_urinary_system0.62525666
79MP0005367_renal/urinary_system_phenotyp0.62525666
80MP0009764_decreased_sensitivity_to0.61462837
81MP0003172_abnormal_lysosome_physiology0.60686902
82MP0006035_abnormal_mitochondrial_morpho0.60465862
83MP0009643_abnormal_urine_homeostasis0.59968050
84MP0000858_altered_metastatic_potential0.59735112
85MP0002396_abnormal_hematopoietic_system0.59608490
86MP0008770_decreased_survivor_rate0.59193716
87MP0002733_abnormal_thermal_nociception0.58790370
88MP0001542_abnormal_bone_strength0.58469902
89MP0000371_diluted_coat_color0.57407321
90MP0003436_decreased_susceptibility_to0.56378401
91MP0003011_delayed_dark_adaptation0.55410705
92MP0004134_abnormal_chest_morphology0.54759697
93MP0002019_abnormal_tumor_incidence0.53336819
94MP0001881_abnormal_mammary_gland0.52027249
95MP0001243_abnormal_dermal_layer0.49628138
96MP0002998_abnormal_bone_remodeling0.48571985
97MP0001765_abnormal_ion_homeostasis0.48389364
98MP0005319_abnormal_enzyme/_coenzyme0.48370220
99MP0002136_abnormal_kidney_physiology0.48327869
100MP0002837_dystrophic_cardiac_calcinosis0.46310874

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)7.59905455
2T lymphocytopenia (HP:0005403)7.28201377
3Hypoproteinemia (HP:0003075)5.59770785
4Autoimmune hemolytic anemia (HP:0001890)5.56443374
5Abnormal delayed hypersensitivity skin test (HP:0002963)5.02051634
6Abnormality of the prostate (HP:0008775)4.90511797
7Increased IgM level (HP:0003496)4.70236218
8Abnormality of T cells (HP:0002843)4.63546161
9Ureteral stenosis (HP:0000071)4.51407806
10IgG deficiency (HP:0004315)4.29936504
11Ureteral obstruction (HP:0006000)4.21281008
12Hemiplegia (HP:0002301)4.06764849
13Abnormality of eosinophils (HP:0001879)4.01321879
14Recurrent bronchitis (HP:0002837)3.90079974
15Chronic diarrhea (HP:0002028)3.89930332
16Obstructive lung disease (HP:0006536)3.84457874
17Chronic obstructive pulmonary disease (HP:0006510)3.84457874
18Severe combined immunodeficiency (HP:0004430)3.81692258
19Gangrene (HP:0100758)3.72830692
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69331790
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69331790
22Chest pain (HP:0100749)3.63459440
23Meningitis (HP:0001287)3.60050170
24Hemoptysis (HP:0002105)3.53242263
25Hypoplasia of the thymus (HP:0000778)3.43689076
26Thyroiditis (HP:0100646)3.39971605
27Recurrent cutaneous fungal infections (HP:0011370)3.39762411
28Chronic mucocutaneous candidiasis (HP:0002728)3.39762411
29Vasculitis (HP:0002633)3.23663144
30Autoimmune thrombocytopenia (HP:0001973)3.13772542
31Eosinophilia (HP:0001880)3.12705292
32Gastrointestinal infarctions (HP:0005244)3.09872821
33Pulmonary infiltrates (HP:0002113)3.05571645
34Hypoalbuminemia (HP:0003073)3.01497866
35Abnormal albumin level (HP:0012116)3.01497866
36Combined immunodeficiency (HP:0005387)2.96152435
37Abnormality of male internal genitalia (HP:0000022)2.95179854
38Zonular cataract (HP:0010920)2.93196514
39Leukocytosis (HP:0001974)2.91231001
40Granulocytopenia (HP:0001913)2.85059444
41Encephalitis (HP:0002383)2.84586123
42Abnormality of the pleura (HP:0002103)2.80222350
43Tetraplegia (HP:0002445)2.80061915
443-Methylglutaconic aciduria (HP:0003535)2.66824414
45Focal motor seizures (HP:0011153)2.65325369
46Abnormality of the alveolar ridges (HP:0006477)2.63012213
47Visual hallucinations (HP:0002367)2.62076394
48Abnormality of T cell physiology (HP:0011840)2.61632890
49Pulmonary fibrosis (HP:0002206)2.61209991
50Carpal bone hypoplasia (HP:0001498)2.60712157
51Pulmonary embolism (HP:0002204)2.58708268
52J-shaped sella turcica (HP:0002680)2.53492623
53Amaurosis fugax (HP:0100576)2.52805180
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.50487535
55Agammaglobulinemia (HP:0004432)2.49205675
56Abnormality of the pericardium (HP:0001697)2.40584039
57Abnormality of macrophages (HP:0004311)2.39178022
58Recurrent skin infections (HP:0001581)2.36854305
59Albinism (HP:0001022)2.36765245
60Bronchitis (HP:0012387)2.35033286
61Abnormality of binocular vision (HP:0011514)2.34343400
62Diplopia (HP:0000651)2.34343400
63Recurrent otitis media (HP:0000403)2.30971731
64Aplastic anemia (HP:0001915)2.30383904
65Pustule (HP:0200039)2.29425427
66Abnormality of midbrain morphology (HP:0002418)2.23447571
67Molar tooth sign on MRI (HP:0002419)2.23447571
68Elevated erythrocyte sedimentation rate (HP:0003565)2.22974002
69Stomatitis (HP:0010280)2.20472029
70Periorbital edema (HP:0100539)2.19437391
71Recurrent fungal infections (HP:0002841)2.19410801
72Acute necrotizing encephalopathy (HP:0006965)2.18011278
73Facial edema (HP:0000282)2.15187382
74Lymphopenia (HP:0001888)2.13910280
75Joint swelling (HP:0001386)2.12060045
76Glomerulopathy (HP:0100820)2.08385609
77Polyneuropathy (HP:0001271)2.02497123
78Pancreatitis (HP:0001733)2.01257541
79Skin rash (HP:0000988)1.98536313
80Lymphoma (HP:0002665)1.98159724
81Periodontitis (HP:0000704)1.96410714
82Abnormal mitochondria in muscle tissue (HP:0008316)1.94534694
83Abnormality of the astrocytes (HP:0100707)1.93840912
84Astrocytoma (HP:0009592)1.93840912
85Melanoma (HP:0002861)1.93347397
86Retinopathy (HP:0000488)1.93078683
87Myositis (HP:0100614)1.91661192
88Recurrent viral infections (HP:0004429)1.90475735
89Recurrent bacterial skin infections (HP:0005406)1.89695907
90Alveolar cell carcinoma (HP:0006519)1.89126461
91Amyotrophic lateral sclerosis (HP:0007354)1.87688380
92Bifid tongue (HP:0010297)1.87295908
93Pancreatic cysts (HP:0001737)1.86108481
94Thrombophlebitis (HP:0004418)1.84674244
95Panhypogammaglobulinemia (HP:0003139)1.84653202
96Stomach cancer (HP:0012126)1.83040947
97Progressive macrocephaly (HP:0004481)1.82434514
98Abnormality of B cell number (HP:0010975)1.80159003
99Glioma (HP:0009733)1.79433207
100Recurrent abscess formation (HP:0002722)1.79186545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.82089398
2BUB14.29242269
3ITK2.98656026
4MAP4K12.62949112
5GRK72.58739059
6PRKCQ2.31369847
7TRIM282.14503377
8ADRBK22.10732482
9FES2.07876930
10TXK10.7066666
11ZAK1.98614446
12JAK31.94668009
13CSK1.89054531
14BCKDK1.71298552
15TYRO31.58025653
16LCK1.53097507
17TBK11.35977340
18SYK1.34674071
19ZAP701.33452404
20MAP3K121.32907163
21PIK3CA1.22804062
22MAPKAPK31.20531851
23IKBKE1.19356599
24WNK41.08707193
25PIK3CG1.07101367
26BCR1.05602161
27MST41.04935939
28TESK21.01224562
29MYLK0.99526818
30SRPK10.90442249
31PDGFRB0.86705433
32FGFR10.85931268
33TEC0.84923217
34JAK20.81040727
35TIE10.80487130
36IKBKB0.79175334
37LYN0.79019612
38FYN0.78861346
39DAPK10.78725257
40BTK0.75573206
41CSF1R0.75138134
42AKT30.70878252
43GRK10.68223840
44RIPK40.63022847
45TNK20.60550994
46NTRK10.59584548
47NUAK10.59342233
48TGFBR20.58568190
49INSR0.55551961
50MAP2K60.55220783
51VRK20.54284793
52IGF1R0.53313328
53FRK0.49319062
54MAP2K70.47404818
55STK160.46610110
56MATK0.46037805
57CAMK2A0.44411442
58MAP3K50.44297544
59BMPR1B0.42865019
60VRK10.41919748
61ROCK10.38964947
62PIM10.38855206
63PRKCA0.35307267
64CAMK2D0.34799476
65CSNK1A10.34293046
66PIM20.33877836
67MAPKAPK20.33641840
68BLK0.32890526
69INSRR0.32324697
70PRKCH0.31544359
71PNCK0.31459299
72NEK10.31209888
73OBSCN0.30750279
74TAOK30.29493500
75PRKACA0.28420708
76IRAK40.26538887
77ADRBK10.26386920
78MAPK30.26093878
79JAK10.25980589
80LIMK10.25971047
81PDK10.25035651
82CAMK2G0.24976259
83ATR0.24360277
84MAP3K110.23912256
85AURKA0.23854161
86EIF2AK30.23246065
87CHUK0.22272159
88STK100.21217499
89CLK10.20607316
90DYRK1B0.19994690
91EIF2AK20.19648546
92MELK0.18340261
93PRKACG0.18139244
94MUSK0.17476609
95PRKCE0.16274662
96CSNK2A10.15282159
97GRK50.15099205
98BMPR20.13651437
99MAPK120.13647555
100PAK10.12893983

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.33771107
2Autoimmune thyroid disease_Homo sapiens_hsa053204.49227299
3Graft-versus-host disease_Homo sapiens_hsa053324.32027970
4Allograft rejection_Homo sapiens_hsa053303.85961385
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.78555808
6Rheumatoid arthritis_Homo sapiens_hsa053233.75663974
7Type I diabetes mellitus_Homo sapiens_hsa049403.15302427
8T cell receptor signaling pathway_Homo sapiens_hsa046603.05612029
9Antigen processing and presentation_Homo sapiens_hsa046122.97433451
10Hematopoietic cell lineage_Homo sapiens_hsa046402.80973114
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.80258682
12Salmonella infection_Homo sapiens_hsa051322.67283783
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62355643
14Proteasome_Homo sapiens_hsa030502.59684074
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.35145245
16Measles_Homo sapiens_hsa051622.09161875
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.05284633
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86445299
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.86102579
20Viral myocarditis_Homo sapiens_hsa054161.61082271
21Chemokine signaling pathway_Homo sapiens_hsa040621.60495476
22Prion diseases_Homo sapiens_hsa050201.59215597
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.51511052
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51154422
25Asthma_Homo sapiens_hsa053101.49430237
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.30638145
27Oxidative phosphorylation_Homo sapiens_hsa001901.14820951
28Staphylococcus aureus infection_Homo sapiens_hsa051501.04387832
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03123354
30Parkinsons disease_Homo sapiens_hsa050121.01291596
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97020519
32Protein export_Homo sapiens_hsa030600.95620459
33TNF signaling pathway_Homo sapiens_hsa046680.90823842
34Herpes simplex infection_Homo sapiens_hsa051680.90084417
35Leishmaniasis_Homo sapiens_hsa051400.88350989
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78224765
37HTLV-I infection_Homo sapiens_hsa051660.77438348
38Apoptosis_Homo sapiens_hsa042100.76170450
39Osteoclast differentiation_Homo sapiens_hsa043800.72587849
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68229096
41Shigellosis_Homo sapiens_hsa051310.68094290
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62866277
43Epstein-Barr virus infection_Homo sapiens_hsa051690.61138331
44Malaria_Homo sapiens_hsa051440.60519271
45Systemic lupus erythematosus_Homo sapiens_hsa053220.57544563
46Alzheimers disease_Homo sapiens_hsa050100.56658538
47Influenza A_Homo sapiens_hsa051640.54912759
48African trypanosomiasis_Homo sapiens_hsa051430.54121592
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.53618636
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52460459
51Linoleic acid metabolism_Homo sapiens_hsa005910.46764181
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45245546
53Collecting duct acid secretion_Homo sapiens_hsa049660.44312248
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41598673
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39863337
56RNA polymerase_Homo sapiens_hsa030200.38034777
57Nucleotide excision repair_Homo sapiens_hsa034200.32448829
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31372205
59Caffeine metabolism_Homo sapiens_hsa002320.30265921
60Cardiac muscle contraction_Homo sapiens_hsa042600.27947948
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.26829630
62Huntingtons disease_Homo sapiens_hsa050160.26531571
63p53 signaling pathway_Homo sapiens_hsa041150.26192960
64Nitrogen metabolism_Homo sapiens_hsa009100.24988670
65Peroxisome_Homo sapiens_hsa041460.21000394
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20161205
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19471138
68Retinol metabolism_Homo sapiens_hsa008300.19132950
69Lysosome_Homo sapiens_hsa041420.18115609
70Endocytosis_Homo sapiens_hsa041440.16584254
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16320489
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16251118
73Tryptophan metabolism_Homo sapiens_hsa003800.15279942
74Toxoplasmosis_Homo sapiens_hsa051450.15208600
75Tuberculosis_Homo sapiens_hsa051520.14968557
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14799580
77Phototransduction_Homo sapiens_hsa047440.14380426
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13515638
79Phagosome_Homo sapiens_hsa041450.13053750
80Legionellosis_Homo sapiens_hsa051340.12787663
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11643999
82Butanoate metabolism_Homo sapiens_hsa006500.10459829
83Mismatch repair_Homo sapiens_hsa034300.10227571
84N-Glycan biosynthesis_Homo sapiens_hsa005100.07465065
85Alcoholism_Homo sapiens_hsa050340.06217736
86Dorso-ventral axis formation_Homo sapiens_hsa043200.05824630
87Homologous recombination_Homo sapiens_hsa034400.03423915
88Viral carcinogenesis_Homo sapiens_hsa052030.02812477
89RNA degradation_Homo sapiens_hsa03018-0.0767417
90B cell receptor signaling pathway_Homo sapiens_hsa04662-0.0766865
91Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0679589
92Sulfur metabolism_Homo sapiens_hsa00920-0.0512101
93Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0477240
94Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0389080
95Ras signaling pathway_Homo sapiens_hsa04014-0.0369042
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0237638
97Ether lipid metabolism_Homo sapiens_hsa00565-0.0231204
98Basal transcription factors_Homo sapiens_hsa03022-0.0208257
99Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0113777
100Olfactory transduction_Homo sapiens_hsa04740-0.0074852

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