TRAJ49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 secretion (GO:2000484)8.47975906
2negative regulation of B cell proliferation (GO:0030889)8.18088690
3regulation of regulatory T cell differentiation (GO:0045589)7.79542961
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)7.52551112
5intestinal epithelial cell development (GO:0060576)7.29916651
6positive regulation of B cell differentiation (GO:0045579)7.20837955
7pyrimidine nucleoside catabolic process (GO:0046135)6.10450763
8regulation of interleukin-8 secretion (GO:2000482)5.96967832
9eosinophil chemotaxis (GO:0048245)5.93957231
10negative regulation by host of viral transcription (GO:0043922)5.51862843
11negative regulation of B cell activation (GO:0050869)5.43599081
12eosinophil migration (GO:0072677)5.37553499
13regulation of B cell differentiation (GO:0045577)5.20563174
14maternal placenta development (GO:0001893)5.20360310
15positive T cell selection (GO:0043368)5.15944032
16positive thymic T cell selection (GO:0045059)5.09526719
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.99580354
18DNA demethylation (GO:0080111)4.84956293
19negative regulation of viral genome replication (GO:0045071)4.84538139
20positive regulation of lymphocyte migration (GO:2000403)4.76030555
21regulation of lymphocyte chemotaxis (GO:1901623)4.47237432
22macrophage chemotaxis (GO:0048246)4.43362930
23regulation of activation of Janus kinase activity (GO:0010533)4.38566442
24regulation of chronic inflammatory response (GO:0002676)4.35329849
25actin nucleation (GO:0045010)4.29572275
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10440731
27negative regulation of T cell apoptotic process (GO:0070233)4.05938312
28positive regulation of T cell migration (GO:2000406)3.99866549
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94944889
30pyrimidine-containing compound catabolic process (GO:0072529)3.93703372
31trophoblast giant cell differentiation (GO:0060707)3.85418138
32regulation of chemokine-mediated signaling pathway (GO:0070099)3.82994166
33DNA dealkylation (GO:0035510)3.80868064
34regulation of T cell chemotaxis (GO:0010819)3.77467287
35positive regulation of T cell chemotaxis (GO:0010820)3.77467287
36regulation of T cell tolerance induction (GO:0002664)3.77054744
37regulation of B cell receptor signaling pathway (GO:0050855)3.76987989
38positive regulation of tolerance induction (GO:0002645)3.71587141
39positive regulation of defense response to virus by host (GO:0002230)3.64852330
40positive regulation of monocyte chemotaxis (GO:0090026)3.63156032
41T cell costimulation (GO:0031295)3.59164877
42positive regulation of gamma-delta T cell activation (GO:0046645)3.58298718
43positive regulation of interleukin-1 beta secretion (GO:0050718)3.57646669
44diterpenoid biosynthetic process (GO:0016102)3.57511540
45negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.55644146
46lymphocyte costimulation (GO:0031294)3.54783628
47pyrimidine ribonucleoside metabolic process (GO:0046131)3.52587573
48regulation of lymphocyte migration (GO:2000401)3.48224646
49negative regulation of T cell receptor signaling pathway (GO:0050860)3.46479771
50regulation of T cell migration (GO:2000404)3.44734711
51regulation of mononuclear cell migration (GO:0071675)3.42299488
52positive regulation of chemokine secretion (GO:0090197)3.42139148
53positive regulation of interleukin-1 secretion (GO:0050716)3.38740383
54dendritic cell chemotaxis (GO:0002407)3.37762529
55regulation of viral genome replication (GO:0045069)3.36012031
56regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.33977308
57T cell migration (GO:0072678)3.31906859
58thymic T cell selection (GO:0045061)3.29940480
59positive regulation of calcium-mediated signaling (GO:0050850)3.24032604
60regulation of interleukin-1 beta secretion (GO:0050706)3.23978964
61monocyte chemotaxis (GO:0002548)3.22985761
62negative regulation of viral transcription (GO:0032897)3.22210071
63cellular response to interleukin-15 (GO:0071350)3.17050590
64negative regulation of viral process (GO:0048525)3.15971985
65regulation of gamma-delta T cell differentiation (GO:0045586)3.13303829
66negative T cell selection (GO:0043383)3.12920752
67regulation of tolerance induction (GO:0002643)3.05857840
68regulation of macrophage chemotaxis (GO:0010758)3.02855652
69positive regulation of interleukin-8 production (GO:0032757)3.02466654
70negative regulation of lymphocyte apoptotic process (GO:0070229)3.01182074
71negative regulation of macroautophagy (GO:0016242)2.99811021
72regulation of gamma-delta T cell activation (GO:0046643)2.98471696
73T cell selection (GO:0045058)2.97952489
74regulation of chemokine secretion (GO:0090196)2.96521369
75T cell receptor signaling pathway (GO:0050852)2.93243557
76chemokine-mediated signaling pathway (GO:0070098)2.89735468
77regulation of interleukin-1 secretion (GO:0050704)2.89073417
78negative regulation of response to biotic stimulus (GO:0002832)2.85781540
79cellular response to interferon-beta (GO:0035458)2.85726062
80negative regulation of lymphocyte proliferation (GO:0050672)2.85711752
81negative regulation of mononuclear cell proliferation (GO:0032945)2.85711752
82lymphocyte chemotaxis (GO:0048247)2.84401761
83regulation of T cell receptor signaling pathway (GO:0050856)2.84209951
84locomotory exploration behavior (GO:0035641)2.83944700
85cytolysis (GO:0019835)2.83280779
86activated T cell proliferation (GO:0050798)2.82258767
87positive regulation of T cell apoptotic process (GO:0070234)2.80725917
88positive regulation of macrophage differentiation (GO:0045651)2.80502021
89antigen receptor-mediated signaling pathway (GO:0050851)2.79867145
90negative regulation of lymphocyte differentiation (GO:0045620)2.76911095
91regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76702140
92response to interferon-beta (GO:0035456)2.76105521
93antigen processing and presentation via MHC class Ib (GO:0002475)2.73407205
94biotin metabolic process (GO:0006768)2.73029818
95cytidine deamination (GO:0009972)15.0417325
96cytidine metabolic process (GO:0046087)15.0417325
97cytidine catabolic process (GO:0006216)15.0417325
98pyrimidine ribonucleoside catabolic process (GO:0046133)13.2639924
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.7493755
100DNA deamination (GO:0045006)10.3386908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.41825665
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.26653913
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.01316934
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83287027
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.66565650
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.37437570
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17119379
8RUNX_20019798_ChIP-Seq_JUKART_Human2.88383329
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75206233
10GATA1_22025678_ChIP-Seq_K562_Human2.60006991
11MYB_26560356_Chip-Seq_TH2_Human2.45912476
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43363500
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41175118
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.39350280
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21121138
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02583407
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02583407
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02583407
19GATA3_27048872_Chip-Seq_THYMUS_Human2.01365974
20BP1_19119308_ChIP-ChIP_Hs578T_Human10.8411515
21MYB_26560356_Chip-Seq_TH1_Human1.95579914
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78991873
23GATA3_26560356_Chip-Seq_TH2_Human1.77668884
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76787285
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76747066
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65954194
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55771845
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54258214
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47545883
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39524322
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38919181
32HTT_18923047_ChIP-ChIP_STHdh_Human1.36285390
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35163502
34MAF_26560356_Chip-Seq_TH2_Human1.32664794
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.32368220
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31076790
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.26910559
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.19736714
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.18596929
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18298473
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16491144
42GATA3_26560356_Chip-Seq_TH1_Human1.16444745
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14998431
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14895085
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13269100
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10330081
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.10221470
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.05086616
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.04934169
50EZH2_22144423_ChIP-Seq_EOC_Human1.03584168
51MAF_26560356_Chip-Seq_TH1_Human1.03496904
52STAT1_20625510_ChIP-Seq_HELA_Human1.03479972
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.00951143
54SOX2_19829295_ChIP-Seq_ESCs_Human1.00433654
55NANOG_19829295_ChIP-Seq_ESCs_Human1.00433654
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00315697
57AR_20517297_ChIP-Seq_VCAP_Human0.99984799
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99649909
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99044011
60CIITA_25753668_ChIP-Seq_RAJI_Human0.98182743
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96880697
62NANOG_20526341_ChIP-Seq_ESCs_Human0.95534952
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93171625
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91912252
65UTX_26944678_Chip-Seq_JUKART_Human0.91692672
66PRDM14_20953172_ChIP-Seq_ESCs_Human0.90944326
67BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90435955
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89012319
69GATA6_21074721_ChIP-Seq_CACO-2_Human0.88061955
70POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85774897
71GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85634379
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84718949
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84194691
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82151325
75CTCF_20526341_ChIP-Seq_ESCs_Human0.82091103
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81919801
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80218420
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79991678
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78249607
80SPI1_23547873_ChIP-Seq_NB4_Human0.77524021
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.77481429
82VDR_23849224_ChIP-Seq_CD4+_Human0.76898631
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.76872893
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75849625
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75414332
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75413134
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.73284160
88NCOR_22424771_ChIP-Seq_293T_Human0.73261717
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72901329
90TAF2_19829295_ChIP-Seq_ESCs_Human0.72382699
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71745380
92RBPJ_21746931_ChIP-Seq_IB4_Human0.71428206
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71367636
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70612969
95P53_21459846_ChIP-Seq_SAOS-2_Human0.70439977
96BCL6_27268052_Chip-Seq_Bcells_Human0.70073866
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.69822531
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69145732
99VDR_22108803_ChIP-Seq_LS180_Human0.67558159
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.67493294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.51953756
2MP0001873_stomach_inflammation5.18857569
3MP0001853_heart_inflammation3.84909155
4MP0009333_abnormal_splenocyte_physiolog3.49763556
5MP0009785_altered_susceptibility_to3.47150238
6MP0003763_abnormal_thymus_physiology3.00613177
7MP0002148_abnormal_hypersensitivity_rea2.81041094
8MP0001919_abnormal_reproductive_system2.65768826
9MP0000372_irregular_coat_pigmentation2.61241074
10MP0001835_abnormal_antigen_presentation2.58713571
11MP0003011_delayed_dark_adaptation2.54274513
12MP0002877_abnormal_melanocyte_morpholog2.53563684
13MP0002163_abnormal_gland_morphology2.44796664
14MP0006082_CNS_inflammation2.36914533
15MP0005000_abnormal_immune_tolerance2.32078521
16MP0005025_abnormal_response_to2.21555593
17MP0005310_abnormal_salivary_gland2.20744794
18MP0001800_abnormal_humoral_immune2.19583832
19MP0002420_abnormal_adaptive_immunity2.12004591
20MP0002933_joint_inflammation2.06424241
21MP0001188_hyperpigmentation2.04873137
22MP0001819_abnormal_immune_cell2.03139494
23MP0002723_abnormal_immune_serum2.01559399
24MP0003866_abnormal_defecation1.99534752
25MP0003183_abnormal_peptide_metabolism1.88200090
26MP0000716_abnormal_immune_system1.86375164
27MP0002405_respiratory_system_inflammati1.79006457
28MP0003448_altered_tumor_morphology1.76398466
29MP0000733_abnormal_muscle_development1.74541253
30MP0005389_reproductive_system_phenotype1.74104938
31MP0002452_abnormal_antigen_presenting1.71494441
32MP0002398_abnormal_bone_marrow1.70611102
33MP0000703_abnormal_thymus_morphology1.66248794
34MP0002876_abnormal_thyroid_physiology1.63612283
35MP0009379_abnormal_foot_pigmentation1.60423546
36MP0003806_abnormal_nucleotide_metabolis1.60101870
37MP0005075_abnormal_melanosome_morpholog1.46981645
38MP0010155_abnormal_intestine_physiology1.45771024
39MP0002722_abnormal_immune_system1.45595553
40MP0006054_spinal_hemorrhage1.44716077
41MP0001790_abnormal_immune_system1.41119209
42MP0005387_immune_system_phenotype1.41119209
43MP0010307_abnormal_tumor_latency1.39627406
44MP0002429_abnormal_blood_cell1.38903725
45MP0005174_abnormal_tail_pigmentation1.38729433
46MP0000689_abnormal_spleen_morphology1.37797962
47MP0005379_endocrine/exocrine_gland_phen1.37306280
48MP0001845_abnormal_inflammatory_respons1.29373320
49MP0009765_abnormal_xenobiotic_induced1.25931000
50MP0004381_abnormal_hair_follicle1.17886667
51MP0002419_abnormal_innate_immunity1.14659494
52MP0003137_abnormal_impulse_conducting1.14488358
53MP0002102_abnormal_ear_morphology1.10030967
54MP0003172_abnormal_lysosome_physiology1.06888648
55MP0002166_altered_tumor_susceptibility1.06763978
56MP0003567_abnormal_fetal_cardiomyocyte1.05505271
57MP0004947_skin_inflammation0.99443184
58MP0009763_increased_sensitivity_to0.97685863
59MP0000613_abnormal_salivary_gland0.96638500
60MP0003786_premature_aging0.94780396
61MP0002006_tumorigenesis0.94768121
62MP0001984_abnormal_olfaction0.93853643
63MP0005623_abnormal_meninges_morphology0.93440800
64MP0003045_fibrosis0.93138319
65MP0008789_abnormal_olfactory_epithelium0.92909296
66MP0008469_abnormal_protein_level0.90177000
67MP0005464_abnormal_platelet_physiology0.87282624
68MP0001485_abnormal_pinna_reflex0.85918542
69MP0005410_abnormal_fertilization0.85422886
70MP0003878_abnormal_ear_physiology0.84650799
71MP0005377_hearing/vestibular/ear_phenot0.84650799
72MP0002234_abnormal_pharynx_morphology0.83369541
73MP0009764_decreased_sensitivity_to0.83240051
74MP0003436_decreased_susceptibility_to0.82680281
75MP0008873_increased_physiological_sensi0.82283060
76MP0004134_abnormal_chest_morphology0.76422734
77MP0002095_abnormal_skin_pigmentation0.74443541
78MP0000015_abnormal_ear_pigmentation0.73658571
79MP0002693_abnormal_pancreas_physiology0.73450542
80MP0002019_abnormal_tumor_incidence0.69534493
81MP0002277_abnormal_respiratory_mucosa0.68748507
82MP0000371_diluted_coat_color0.65732075
83MP0003075_altered_response_to0.65154683
84MP0004036_abnormal_muscle_relaxation0.62152835
85MP0008995_early_reproductive_senescence0.61932378
86MP0009643_abnormal_urine_homeostasis0.60852306
87MP0002396_abnormal_hematopoietic_system0.59349884
88MP0004145_abnormal_muscle_electrophysio0.59219114
89MP0003724_increased_susceptibility_to0.57601848
90MP0001663_abnormal_digestive_system0.56702738
91MP0002138_abnormal_hepatobiliary_system0.55958218
92MP0000920_abnormal_myelination0.55556989
93MP0004185_abnormal_adipocyte_glucose0.54334333
94MP0005408_hypopigmentation0.53950351
95MP0010386_abnormal_urinary_bladder0.53379643
96MP0005499_abnormal_olfactory_system0.52698348
97MP0005394_taste/olfaction_phenotype0.52698348
98MP0004130_abnormal_muscle_cell0.50849664
99MP0000685_abnormal_immune_system0.50285455
100MP0008007_abnormal_cellular_replicative0.47859234

Predicted human phenotypes

RankGene SetZ-score
1Ureteral stenosis (HP:0000071)6.10863280
2Abnormality of the prostate (HP:0008775)6.07289879
3Aplastic anemia (HP:0001915)5.73158382
4Ureteral obstruction (HP:0006000)5.69627730
5Abnormality of T cell number (HP:0011839)5.38580653
6Autoimmune hemolytic anemia (HP:0001890)5.36003629
7T lymphocytopenia (HP:0005403)5.20188524
8Pulmonary fibrosis (HP:0002206)4.70817736
9Chest pain (HP:0100749)4.65969127
10Gangrene (HP:0100758)4.51383827
11Hypoproteinemia (HP:0003075)4.47203467
12Pulmonary infiltrates (HP:0002113)4.46926358
13Obstructive lung disease (HP:0006536)4.21004417
14Chronic obstructive pulmonary disease (HP:0006510)4.21004417
15Oral leukoplakia (HP:0002745)4.03958497
16Hemoptysis (HP:0002105)4.00728056
17Abnormality of male internal genitalia (HP:0000022)3.99492686
18Pulmonary embolism (HP:0002204)3.69669121
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.63403277
203-Methylglutaconic aciduria (HP:0003535)3.57398010
21Abnormality of the pleura (HP:0002103)3.53697424
22Meningitis (HP:0001287)3.48732621
23Abnormality of the pericardium (HP:0001697)3.43660016
24Abnormality of T cells (HP:0002843)3.32037906
25Abnormal albumin level (HP:0012116)3.26816619
26Hypoalbuminemia (HP:0003073)3.26816619
27Elevated erythrocyte sedimentation rate (HP:0003565)3.26428071
28Seborrheic dermatitis (HP:0001051)3.25523493
29Carpal bone hypoplasia (HP:0001498)3.24392288
30Vasculitis (HP:0002633)3.23374285
31Severe visual impairment (HP:0001141)3.12386886
32Ketoacidosis (HP:0001993)3.03105105
33Chronic diarrhea (HP:0002028)2.99689101
34Thrombophlebitis (HP:0004418)2.94467019
35Restrictive lung disease (HP:0002091)2.82636143
36J-shaped sella turcica (HP:0002680)2.77415366
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74673962
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74673962
39Retrobulbar optic neuritis (HP:0100654)2.74616461
40Optic neuritis (HP:0100653)2.74616461
41Polyneuropathy (HP:0001271)2.73982159
42Glomerulopathy (HP:0100820)2.71816770
43Arterial thrombosis (HP:0004420)2.66506220
44Gastrointestinal infarctions (HP:0005244)2.66331958
45Skin rash (HP:0000988)2.64742513
46Abnormality of the parietal bone (HP:0002696)2.56788291
47Increased intramyocellular lipid droplets (HP:0012240)2.56558236
48Periorbital edema (HP:0100539)2.56345601
49Facial edema (HP:0000282)2.56043846
50Recurrent skin infections (HP:0001581)2.55144092
51Tachypnea (HP:0002789)2.51195046
52IgG deficiency (HP:0004315)2.47934435
53Alveolar cell carcinoma (HP:0006519)2.43757514
54Epistaxis (HP:0000421)2.42000505
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41850517
56Hematochezia (HP:0002573)2.38306147
57Amaurosis fugax (HP:0100576)2.37699499
58Progressive external ophthalmoplegia (HP:0000590)2.34877720
59Recurrent bronchitis (HP:0002837)2.34421436
60Retinopathy (HP:0000488)2.31178922
61Premature graying of hair (HP:0002216)2.31112229
62Increased muscle lipid content (HP:0009058)2.29972781
63Paresthesia (HP:0003401)2.29374544
64Abnormal mitochondria in muscle tissue (HP:0008316)2.27584021
65Pancreatitis (HP:0001733)2.26701955
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.26691162
67Joint swelling (HP:0001386)2.26330106
68Abnormality of binocular vision (HP:0011514)2.22844184
69Diplopia (HP:0000651)2.22844184
70Acute necrotizing encephalopathy (HP:0006965)2.22611895
71Orchitis (HP:0100796)2.22310499
72Abnormal tarsal ossification (HP:0008369)2.21382715
73Abnormality of macrophages (HP:0004311)2.21256917
74Increased IgM level (HP:0003496)2.17982961
75Severe combined immunodeficiency (HP:0004430)2.14151325
76Abnormality of eosinophils (HP:0001879)2.13226792
77Lymphopenia (HP:0001888)2.12404412
78Dysautonomia (HP:0002459)2.08918472
79Absent hand (HP:0004050)2.06015948
80Neoplasm of the tracheobronchial system (HP:0100552)2.03186995
81Myositis (HP:0100614)1.99424455
82Supernumerary bones of the axial skeleton (HP:0009144)1.97787688
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.96682360
84Abnormality of glycolipid metabolism (HP:0010969)1.96682360
85Abnormality of liposaccharide metabolism (HP:0010968)1.96682360
86Recurrent otitis media (HP:0000403)1.95144078
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93161180
88Pigmentary retinal degeneration (HP:0001146)1.92808835
89Eosinophilia (HP:0001880)1.91302962
90Thyroiditis (HP:0100646)1.90977357
91Amyotrophic lateral sclerosis (HP:0007354)1.90668791
92Progressive macrocephaly (HP:0004481)1.82593418
93Mitochondrial inheritance (HP:0001427)1.81889143
94Hypoplasia of the thymus (HP:0000778)1.80267306
95Abnormality of T cell physiology (HP:0011840)1.80162307
96Mediastinal lymphadenopathy (HP:0100721)1.80113700
97Keratoconjunctivitis sicca (HP:0001097)1.73513836
98Hemiplegia (HP:0002301)1.72936779
99Anhidrosis (HP:0000970)1.72283608
100Flat capital femoral epiphysis (HP:0003370)1.71658005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.81004716
2MST43.31191884
3BMPR1B3.07865588
4FES2.13070469
5ITK2.03575213
6TXK12.8567774
7MAP2K61.83119260
8MAP4K11.82321703
9RIPK41.82105814
10NTRK11.79750190
11PIK3CG1.71254296
12SCYL21.65674552
13CSK1.58042045
14MATK1.55640511
15TYRO31.52914140
16GRK71.42068655
17MAP3K131.35642381
18ADRBK21.31811484
19TRIM281.24508936
20IKBKB1.23444992
21LCK1.18025728
22SYK1.13311648
23PRKCQ1.10192472
24WNK41.00575279
25EIF2AK30.99796232
26BMPR20.94583330
27JAK20.87017924
28GRK10.86864874
29OXSR10.83719861
30FYN0.83467361
31BUB10.80893258
32TAOK30.80847582
33PIM20.79470584
34TIE10.72621379
35CSF1R0.72406535
36IGF1R0.71475446
37ZAK0.70904434
38STK390.65093624
39LYN0.63573157
40TESK20.62083793
41FRK0.62055222
42MAP2K70.61976027
43ZAP700.61147276
44CAMKK20.57450214
45MYLK0.53421803
46JAK30.51380485
47TBK10.47456058
48BTK0.46675725
49OBSCN0.44692780
50IKBKE0.43169305
51PINK10.42639397
52INSRR0.42200293
53CHUK0.41173469
54INSR0.40564676
55PDGFRB0.39337645
56CAMK2A0.38562030
57ARAF0.36410093
58NEK60.35906356
59BLK0.34836142
60ERBB20.34547923
61TEC0.32257767
62MUSK0.31773054
63ROCK10.31293414
64MAP3K90.31132575
65PDK10.30726279
66SRPK10.30712248
67PIK3CA0.29522679
68TGFBR20.28609419
69IRAK40.28344356
70PRKCA0.27068142
71GRK50.26314081
72EGFR0.26284810
73PIM10.25868556
74PRKACA0.24586942
75GRK60.23718721
76CAMK2D0.22991097
77VRK20.22939057
78STK110.22003162
79MAP4K20.20822588
80BCR0.20292557
81MAPKAPK50.17662299
82TNK20.17304917
83ATR0.16507914
84PAK10.16379402
85PRKCG0.16078391
86DAPK30.16026370
87MAPK30.15935499
88AURKA0.15668769
89DYRK1A0.15408305
90NUAK10.15204770
91ABL10.14699519
92PAK30.14685556
93FGR0.13949119
94MAPKAPK20.13710100
95CAMK2G0.13371772
96PRKCD0.12988904
97MAPK90.12628940
98PRKACB0.12209415
99MOS0.12101054
100NEK10.11830852

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.02318431
2Autoimmune thyroid disease_Homo sapiens_hsa053204.85701993
3Graft-versus-host disease_Homo sapiens_hsa053324.30947041
4Proteasome_Homo sapiens_hsa030504.20796857
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.64483654
6Allograft rejection_Homo sapiens_hsa053303.42769839
7Hematopoietic cell lineage_Homo sapiens_hsa046403.10833031
8Rheumatoid arthritis_Homo sapiens_hsa053233.08985390
9T cell receptor signaling pathway_Homo sapiens_hsa046602.92776039
10Type I diabetes mellitus_Homo sapiens_hsa049402.80481770
11Antigen processing and presentation_Homo sapiens_hsa046122.55701890
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.49659809
13Salmonella infection_Homo sapiens_hsa051322.21799402
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.88085757
15Oxidative phosphorylation_Homo sapiens_hsa001901.83606639
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79070215
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.62428142
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58619426
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57164517
20Vitamin digestion and absorption_Homo sapiens_hsa049771.54017005
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53976183
22Measles_Homo sapiens_hsa051621.49852427
23Parkinsons disease_Homo sapiens_hsa050121.41642252
24Viral myocarditis_Homo sapiens_hsa054161.30987447
25Protein export_Homo sapiens_hsa030601.21008500
26RNA polymerase_Homo sapiens_hsa030201.20977957
27Prion diseases_Homo sapiens_hsa050201.20016708
28Shigellosis_Homo sapiens_hsa051311.17283385
29Non-homologous end-joining_Homo sapiens_hsa034501.14761945
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14559716
31Chemokine signaling pathway_Homo sapiens_hsa040621.12720252
32Collecting duct acid secretion_Homo sapiens_hsa049661.07533625
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03921472
34Asthma_Homo sapiens_hsa053100.98178685
35Alzheimers disease_Homo sapiens_hsa050100.95475293
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85142668
37Peroxisome_Homo sapiens_hsa041460.78015455
38Retinol metabolism_Homo sapiens_hsa008300.74338090
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70005087
40African trypanosomiasis_Homo sapiens_hsa051430.66852406
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64926446
42Systemic lupus erythematosus_Homo sapiens_hsa053220.64859330
43Cardiac muscle contraction_Homo sapiens_hsa042600.64620543
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63631000
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63473283
46Nitrogen metabolism_Homo sapiens_hsa009100.62907107
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.62513474
48Linoleic acid metabolism_Homo sapiens_hsa005910.61186389
49Steroid biosynthesis_Homo sapiens_hsa001000.59654361
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59198933
51Phototransduction_Homo sapiens_hsa047440.57764473
52Legionellosis_Homo sapiens_hsa051340.56714573
53Huntingtons disease_Homo sapiens_hsa050160.52414848
54Apoptosis_Homo sapiens_hsa042100.52171316
55TNF signaling pathway_Homo sapiens_hsa046680.48147742
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47999863
57Influenza A_Homo sapiens_hsa051640.47610355
58Osteoclast differentiation_Homo sapiens_hsa043800.46236740
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45474219
60Pertussis_Homo sapiens_hsa051330.45079846
61Staphylococcus aureus infection_Homo sapiens_hsa051500.44211476
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42861941
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41760962
64Herpes simplex infection_Homo sapiens_hsa051680.41221686
65Ether lipid metabolism_Homo sapiens_hsa005650.39733675
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38716337
67Butanoate metabolism_Homo sapiens_hsa006500.37394552
68p53 signaling pathway_Homo sapiens_hsa041150.36604747
69Olfactory transduction_Homo sapiens_hsa047400.36589706
70Homologous recombination_Homo sapiens_hsa034400.33045741
71Malaria_Homo sapiens_hsa051440.32939682
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31773440
73Leishmaniasis_Homo sapiens_hsa051400.31485006
74Epstein-Barr virus infection_Homo sapiens_hsa051690.31019270
75HTLV-I infection_Homo sapiens_hsa051660.30292378
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.28551168
77ABC transporters_Homo sapiens_hsa020100.27789982
78Selenocompound metabolism_Homo sapiens_hsa004500.27276659
79Endocytosis_Homo sapiens_hsa041440.24121946
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23498644
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.21420063
82Non-small cell lung cancer_Homo sapiens_hsa052230.17598321
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16333729
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15874709
85Ras signaling pathway_Homo sapiens_hsa040140.10940166
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10031808
87Ribosome_Homo sapiens_hsa030100.09219263
88Arachidonic acid metabolism_Homo sapiens_hsa005900.08252831
89Tuberculosis_Homo sapiens_hsa051520.06956980
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.06486034
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04984299
92Morphine addiction_Homo sapiens_hsa050320.04324235
93Alcoholism_Homo sapiens_hsa050340.03922705
94Fatty acid elongation_Homo sapiens_hsa000620.03731786
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.03303449
96Phagosome_Homo sapiens_hsa041450.03102303
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.01109958
98Caffeine metabolism_Homo sapiens_hsa002320.00790827
99Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0030254
100Vibrio cholerae infection_Homo sapiens_hsa05110-0.0005911

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